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However, the mechanisms underlying circ_PRKDC in skin wound healing remain unclear. The expression of circ_PRKDC, microRNA (miR)-31 and fibrillin 1 (FBN1) was detected using quantitative reverse transcription-polymerase chain reaction and Western blot assays. The migration ability and the changes of matrix metallopeptidase 9 (MMP-9) and MMP2 levels were determined using wound healing, transwell and Western blot assays. The interaction between miR-31 and circ_PRKDC or FBN1 was verified by dual-luciferase reporter assay. The expression of circ_PRKDC was gradually down-regulated in wound edge at 1 and 7 days after injury relative to the unwounded skin. In human epidermal keratinocytes (HEKa), knockdown of circ_PRKDC promoted cell migration partly through up-regulating MMP-2 and MMP9, while circ_PRKDC overexpression showed opposite effects. In a mechanical study, we confirmed that miR-31 was a target of circ_PRKDC, and inhibition of miR-31 reversed the promotive effect of circ_PRKDC knockdown on HEKa migration. Besides that, miR-31 was verified to target FBN1, and ectopic overexpression of miR-31 accelerated HEKa migration via FBN1. Importantly, we also demonstrated that FBN1 overexpression attenuated the effects of circ_PRKDC knockdown on HEKa migration. In all, circ_PRKDC knockdown promoted HEKa migration during wound healing through miR-31\u002FFBN1 axis, suggesting the therapeutic potential for circ_PRKDC on skin wound healing.",{"EN":196},"Circ_PRKDC knockdown promotes skin wound healing by enhancing keratinocyte migration via miR-31\u002FFBN1 axis",{"VOID":198},"[\"3421358347961109994\"]",{"VOID":200},"Ashworth JL, Murphy G, Rock MJ, Sherratt MJ, Shapiro SD, Shuttleworth CA, Kielty CM (1999) Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling. Biochem J 340(1):171–181\nBian D, Wu Y, Song G (2018) Novel circular RNA, hsa_circ_0025039 promotes cell growth, invasion and glucose metabolism in malignant melanoma via the miR-198\u002FCDK4 axis. Biomedicine pharmacotherapy = Biomedecine pharmacotherapie 108:165–176\nDu WW, Zhang C, Yang W, Yong T, Awan FM, Yang BB (2017) Identifying and characterizing circRNA-protein interaction. Theranostics 7(17):4183–4191\nEming SA, Martin P, Tomic-Canic M (2014) Wound repair and regeneration: mechanisms, signaling, and translation. Science translational medicine 6(265):265sr266\nFalanga V (2005) Wound healing and its impairment in the diabetic foot. Lancet 366(9498):1736–1743\nGuo P, Huang J, Zhang J, Meng C, Zhang S, Bai Y, Ning Z, Hu L (2019) The potential role of circRNA_004229 in hair\u002Fepidermal regulation after MED1 ablation in keratinocytes. RSC Advances 9(33):19095–19103\nHan JA-O, LaVigne CA-O, Jones BA-OX, Zhang HA-O, Gillett FA-O, Mendell JA-O (2020) A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming. Science. https:\u002F\u002Fdoi.org\u002F10.1126\u002Fscience.abc9546\nHansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK, Kjems J (2013) Natural RNA circles function as efficient microRNA sponges. Nature 495(7441):384–388\nHattori N, Mochizuki S, Kishi K, Nakajima T, Takaishi H, D’Armiento J, Okada Y (2009) MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing. Am J Pathol 175(2):533–546\nJeck WR, Sharpless NE (2014) Detecting and characterizing circular RNAs. Nature biotechnology 32(5):453–461\nJo DH, Yun JH, Cho CS, Kim JH, Kim JH, Cho CH (2019) Interaction between microglia and retinal pigment epithelial cells determines the integrity of outer blood-retinal barrier in diabetic retinopathy. Glia 67(2):321–331\nKessenbrock K, Plaks V, Werb Z (2010) Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141(1):52–67\nKrishnaswamy VR, Korrapati PS (2014) Role of dermatopontin in re-epithelialization: implications on keratinocyte migration and proliferation. Scientific reports 4:7385\nLan CC, Liu IH, Fang AH, Wen CH, Wu CS (2008) Hyperglycaemic conditions decrease cultured keratinocyte mobility: implications for impaired wound healing in patients with diabetes. Br J Dermatol 159(5):1103–1115\nLewis CJ, Mardaryev AN, Poterlowicz K, Sharova TY, Aziz A, Sharpe DT, Botchkareva NV, Sharov AA (2014) Bone morphogenetic protein signaling suppresses wound-induced skin repair by inhibiting keratinocyte proliferation and migration. J Invest Dermatol 134(3):827–837\nLi D, Li XI, Wang A, Meisgen F, Pivarcsi A, Sonkoly E, Ståhle M, Landén NX (2015) MicroRNA-31 Promotes Skin Wound Healing by Enhancing Keratinocyte Proliferation and Migration. J Invest Dermatol 135(6):1676–1685\nLiu R, Wang Q, Chang W, Zhou L, Li J, Zhang K (2019) Characterisation of the circular RNA landscape in mesenchymal stem cells from psoriatic skin lesions. European journal of dermatology: EJD 29(1):29–38\nMäkelä M, Larjava H, Pirilä E, Maisi P, Salo T, Sorsa T, Uitto VJ (1999) Matrix metalloproteinase 2 (gelatinase A) is related to migration of keratinocytes. Experimental cell research 251(1):67–78\nMarques-Rocha JL, Samblas M, Milagro FI, Bressan J, Martínez JA, Marti A (2015) Noncoding RNAs, cytokines, and inflammation-related diseases. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 29(9):3595–3611\nMartins VL, Caley M, O’Toole EA (2013) Matrix metalloproteinases and epidermal wound repair. Cell tissue research 351(2):255–268\nRaja, Sivamani K, Garcia MS, Isseroff RR (2007) Wound re-epithelialization: modulating keratinocyte migration in wound healing. Frontiers in bioscience: a journal virtual library 12:2849–2868\nRedd MJ, Cooper L, Wood W, Stramer B, Martin P (2004) Wound healing and inflammation: embryos reveal the way to perfect repair. Philosophical transactions of the Royal Society of London Series B Biological sciences 359(1445):777–784\nRohani MG, Parks WC (2015) Matrix remodeling by MMPs during wound repair. Matrix biology: journal of the International Society for Matrix Biology 44–46:113–121\nSheu-Gruttadauria J, Pawlica P, Klum SM, Wang S, Yario TA, Schirle Oakdale NT, Steitz JA, MacRae IJ (2019) Structural Basis for Target-Directed MicroRNA Degradation. 75:1097–4164\nShi J, Ma X, Su Y, Song Y, Tian Y, Yuan S, Zhang X, Yang D, Zhang H, Shuai J et al (2018) MiR-31 Mediates Inflammatory Signaling to Promote Re-Epithelialization during Skin Wound Healing. J Invest Dermatol 138(10):2253–2263\nShin KO, Choe SJ, Uchida Y, Kim I, Jeong Y, Park K (2018) Ginsenoside Rb1 Enhances Keratinocyte Migration by a Sphingosine-1-Phosphate-Dependent Mechanism. J Med Food 21(11):1129–1136\nShiroto Y, Terashima S, Hosokawa Y, Oka K, Isokawa K, Tsuruga E (2017) The Effect of Ultraviolet B on Fibrillin-1 and Fibrillin-2 in Human Non-pigmented Ciliary Epithelial Cells In Vitro. Acta histochemica et cytochemica 50(3):105–109\nSi C, Wang J, Ma W, Hua H, Zhang M, Qian W, Zhou B, Luo D (2019) Circular RNA expression profile in human fibroblast premature senescence after repeated ultraviolet B irradiations revealed by microarray. Journal of cellular physiology 234(10):18156–18168\nWang M-L, Chen J, Zhou Y, Zhao Y-J, Sun D-R, Wu Q, Bi C-L (2018) MiR-503 promotes wound healing of diabetic foot ulcer by targeting FBN1. Asian Pacific Journal of Tropical Medicine 11(3):245–250\nWang A, Toma MA, Ma J, Li D, Vij M, Chu T, Wang J, Li X, Xu Landén N (2020) Circular RNA hsa_circ_0084443 Is Upregulated in Diabetic Foot Ulcer and Modulates Keratinocyte Migration and Proliferation. Advances in wound care 9(4):145–160\nWilusz JE, Sharp PA (2013) Molecular biology. A circuitous route to noncoding RNA. Science 340(6131):440–441\nWoodley DT, O’Keefe EJ, Prunieras M (1985) Cutaneous wound healing: a model for cell-matrix interactions. J Am Acad Dermatol 12(2 Pt 2):420–433\nWu X, Xiao Y, Ma J, Wang A (2020) Circular RNA: A novel potential biomarker for skin diseases. Pharmacological research 158:104841\nYang L, Zheng Z, Zhou Q, Bai X, Fan L, Yang C, Su L, Hu D (2017) miR-155 promotes cutaneous wound healing through enhanced keratinocytes migration by MMP-2. J Mol Histol 48(2):147–155\nYang ZG, Awan FM, Du WW, Zeng Y, Lyu J, Wu D, Gupta S, Yang W, Yang BB (2017) The Circular RNA Interacts with STAT3, Increasing Its Nuclear Translocation and Wound Repair by Modulating Dnmt3a and miR-17 Function. Molecular therapy: the journal of the American Society of Gene Therapy 25(9):2062–2074\nZhao P, Sui BD, Liu N, Lv YJ, Zheng CX, Lu YB, Huang WT, Zhou CH, Chen J, Pang DL et al (2017) Anti-aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application. 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Laminin-5 (Ln-5) plays an important role for tumour migration and shows an increased expression in areas of direct tumour\u002Fstroma interactions. We have previously shown stromal spot like Ln-5\u002Fγ2 chain deposits distant from the basement membrane region. In this study we have analysed which cell type is responsible for Ln-5\u002Fγ2 chain synthesis in situ. Furthermore, we studied its spatial relation to TGF-β1 as well as the Ln-5 modulating enzymes matrix metalloproteinase (MMP) 2, membrane type-1 (MT1-) MMP and bone morphogenetic protein (BMP-) 1 by different techniques including triple immunofluorescence labelling and in situ hybridisation in OSCC. We found that the stromal spot-like Ln-5 deposits occurred in the invasive front in the vicinity of mesenchymal cells and vessel structures. In particular, not only carcinoma cells but also mesenchymal cells were shown to express the Ln-5\u002Fγ2 chain mRNA. 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J Cell Sci 111:1929–1940",{"doi":562},{"id":558,"text":600,"url":560,"identifiers":601},"Fortunato SJ, Menon R, Lombardi SJ (1998) Expression of a progelatinase activator (MT1-MMP) in human fetal membranes. Am J Reprod Immunol 39:316–322",{"doi":562},{"id":558,"text":603,"url":560,"identifiers":604},"Franz M, Hansen T, Richter P, Borsi L, Boehmer FD, Hyckel P, Schleier P, Katenkamp D, Zardi L, Kosmehl H, Berndt A (2006) Complex formation of the laminin-5 gamma2 chain and large unspliced tenascin-C in oral squamous cell carcinoma in vitro and in situ: implications for sequential modulation of extracellular matrix in the invasive tumor front. Histochem Cell Biol 126:125–131",{"doi":562},{"id":558,"text":606,"url":560,"identifiers":607},"Gagnoux-Palacios L, Allegra M, Spirito F, Pommeret O, Romero C, Ortonne JP, Meneguzzi G (2001) The short arm of the laminin gamma2 chain plays a pivotal role in the incorporation of laminin 5 into the extracellular matrix and in cell adhesion. J Cell Biol 153:835–850",{"doi":562},{"id":558,"text":609,"url":560,"identifiers":610},"Ge G, Greenspan DS (2006) BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein. J Cell Biol 175:111–120",{"doi":562},{"id":558,"text":612,"url":560,"identifiers":613},"Giannelli G, Bergamini C, Fransvea E, Sgarra C, Antonaci S (2005) Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma. Gastroenterology 129:1375–1383",{"doi":562},{"id":558,"text":615,"url":560,"identifiers":616},"Giannelli G, Falk-Marzillier J, Schiraldi O, Stetler-Stevenson WG, Quaranta V (1997) Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5. Science 277:225–228",{"doi":562},{"id":558,"text":618,"url":560,"identifiers":619},"Haapasalmi K, Makela M, Oksala O, Heino J, Yamada KM, Uitto VJ, Larjava H (1995) Expression of epithelial adhesion proteins and integrins in chronic inflammation. Am J Pathol 147:193–206",{"doi":562},{"id":558,"text":621,"url":560,"identifiers":622},"Haas KM, Berndt A, Stiller KJ, Hyckel P, Kosmehl H (2001) A comparative quantitative analysis of laminin-5 in the basement membrane of normal, hyperplastic, and malignant oral mucosa by confocal immunofluorescence imaging. J Histochem Cytochem 49:1261–1268",{"doi":562},{"id":558,"text":624,"url":560,"identifiers":625},"Hase T, Kawashiri S, Tanaka A, Nozaki S, Noguchi N, Kato K, Nakaya H, Nakagawa K (2006) Correlation of basic fibroblast growth factor expression with the invasion and the prognosis of oral squamous cell carcinoma. J Oral Pathol Med 35:136–139",{"doi":562},{"id":558,"text":627,"url":560,"identifiers":628},"Hatakeyama S, Gao YH, Ohara-Nemoto Y, Kataoka H, Satoh M (1997) Expression of bone morphogenetic proteins of human neoplastic epithelial cells. Biochem Mol Biol Int 42:497–505",{"doi":562},{"id":558,"text":630,"url":560,"identifiers":631},"Horstmeyer A, Licht C, Scherr G, Eckes B, Krieg T (2005) Signalling and regulation of collagen I synthesis by ET-1 and TGF-beta1. FEBS J 272:6297–6309",{"doi":562},{"id":20,"text":633,"url":20,"identifiers":634},"Jin X, Li J, Li Z, Li Y (2001) Expression of transforming growth factor beta(TGFbeta) subtypes in oral squamous cell carcinoma. Hua Xi Kou Qiang Yi Xue Za Zhi 19:377–379",{},{"id":558,"text":636,"url":560,"identifiers":637},"Jinnin M, Ihn H, Asano Y, Yamane K, Trojanowska M, Tamaki K (2004) Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1. Oncogene 23:1656–1667",{"doi":562},{"id":558,"text":639,"url":560,"identifiers":640},"Kagesato Y, Mizushima H, Koshikawa N, Kitamura H, Hayashi H, Ogawa N, Tsukuda M, Miyazaki K (2001) Sole expression of laminin gamma 2 chain in 20 invading tumor cells and its association with stromal fibrosis in lung adenocarcinomas. Jpn J Cancer Res 92:184–192",{"doi":562},{"id":558,"text":642,"url":560,"identifiers":643},"Katayama M, Sekiguchi K (2004) Laminin-5 in epithelial tumour invasion. J Mol Histol 35:277–286",{"doi":562},{"id":558,"text":645,"url":560,"identifiers":646},"Kato K, Hara A, Kuno T, Kitaori N, Huilan Z, Mori H, Toida M, Shibata T (2005) Matrix metalloproteinases 2 and 9 in oral squamous cell carcinomas: manifestation and localization of their activity. J Cancer Res Clin Oncol 131:340–346",{"doi":562},{"id":558,"text":648,"url":560,"identifiers":649},"Kawano K, Yanagisawa S (2005) Predictive value of laminin-5 and membrane type 1-matrix metalloproteinase expression for cervical lymph node metastasis in T1 and T2 squamous cell carcinomas of the tongue and floor of the mouth. Head Neck 28:525–533",{"doi":562},{"id":558,"text":651,"url":560,"identifiers":652},"Korang K, Christiano AM, Uitto J, Mauviel A (1995) Differential cytokine modulation of the genes LAMA3, LAMB3, and LAMC2, encoding the constitutive polypeptides, alpha 3, beta 3, and gamma 2, of human laminin 5 in epidermal keratinocytes. FEBS Lett 368:556–558",{"doi":562},{"id":558,"text":654,"url":560,"identifiers":655},"Koshikawa N, Minegishi T, Sharabi A, Quaranta V, Seiki M (2005) Membranetype matrix metalloproteinase-1 (MT1-MMP) is a processing enzyme for human laminin gamma 2 chain. J Biol Chem 280:88–93",{"doi":562},{"id":558,"text":657,"url":560,"identifiers":658},"Koshikawa N, Moriyama K, Takamura H, Mizushima H, Nagashima Y, Yanoma S, Miyazaki K (1999) Overexpression of laminin gamma2 chain monomer in invading gastric carcinoma cells. Cancer Res 59:5596–5601",{"doi":562},{"id":660,"text":661,"url":662,"identifiers":663},"e90eec39-2922-4d74-9ee8-89ee3fd3512f","Kosmehl H, Berndt A, Katenkamp D (1996) Molecular variants of fibronectin and laminin: structure, physiological occurrence and histopathological aspects. Virchows Arch 429:311–322","http:\u002F\u002Flink.springer.com\u002F10.1007\u002FBF00198435",{"doi":664},"10.1007\u002FBF00198435",{"id":558,"text":666,"url":560,"identifiers":667},"Kosmehl H, Berndt A, Strassburger S, Borsi L, Rousselle P, Mandel U, Hyckel P, Zardi L, Katenkamp D (1999) Distribution of laminin and fibronectin isoforms in oral mucosa and oral squamous cell carcinoma. Br J Cancer 81:1071–1079",{"doi":562},{"id":558,"text":669,"url":560,"identifiers":670},"Kurahara S, Shinohara M, Ikebe T, Nakamura S, Beppu M, Hiraki A, Takeuchi H, Shirasuna K (1999) Expression of MMPs, MT-MMP, and TIMPs in squamous cell carcinoma of the oral cavity: correlations with tumor invasion and metastasis. Head Neck 21:627–638",{"doi":562},{"id":558,"text":672,"url":560,"identifiers":673},"Lee S, Solow-Cordero DE, Kessler E, Takahara K, Greenspan DS (1997) Transforming growth factor-beta regulationof bone morphogenetic protein-1\u002Fprocollagen C-proteinase and related proteins in fibrogenic cells and keratinocytes. J Biol Chem 272:19059–19066",{"doi":562},{"id":558,"text":675,"url":560,"identifiers":676},"Lewis MP, Lygoe KA, Nystrom ML, Anderson WP, Speight PM, Marshall JF, Thomas GJ (2004) Tumour-derived TGF-beta1 modulates myofibroblast differentiation and promotes HGF\u002FSF-dependent invasion of squamous carcinoma cells. Br J Cancer 90:822–832",{"doi":562},{"id":558,"text":678,"url":560,"identifiers":679},"Libby RT, Champliaud MF, Claudepierre T, Xu Y, Gibbons EP, Koch M, Burgeson RE, Hunter DD, Brunken WJ (2000) Laminin expression in adult and developing retinae: evidence of two novel CNS laminins. J Neurosci 20:6517–6528",{"doi":562},{"id":558,"text":681,"url":560,"identifiers":682},"Manda R, Kohno T, Niki T, Yamada T, Takenoshita S, Kuwano H, Yokota J (2000) Differential expression of the LAMB3 and LAMC2 genes between small cell and non-small cell lung carcinomas. Biochem Biophys Res Commun 275:440–445",{"doi":562},{"id":558,"text":684,"url":560,"identifiers":685},"Manders EMM, Verbeek FJ, Aten JA (1992) Measurement of co-localization of objects in dual-colour confocal images. J Micros 169:375–382",{"doi":562},{"id":558,"text":687,"url":560,"identifiers":688},"Masunaga T, Shimizu H, Ishiko A, Tomita Y, Aberdam D, Ortonne JP, Nishikawa T (1996) Localization of laminin-5 in the epidermal basement membrane. J Histochem Cytochem 44:1223–1230",{"doi":562},{"id":558,"text":690,"url":560,"identifiers":691},"Meneguzzi G, Marinkovich MP, Aberdam D, Pisani A, Burgeson R, Ortonne JP (1992) Kalinin is abnormally expressed in epithelial basement membranes of Herlitz’s junctional epidermolysis bullosa patients. Exp Dermatol 1:221–229",{"doi":562},{"id":558,"text":693,"url":560,"identifiers":694},"Miyazaki K, Kikkawa Y, Nakamura A, Yasumitsu H, Umeda M (1993) A large cell-adhesive scatter factor secreted by human gastric carcinoma cells. Proc Natl Acad Sci USA 90:11767–11771",{"doi":562},{"id":558,"text":696,"url":560,"identifiers":697},"Mizushima H, Koshikawa N, Moriyama K, Takamura H, Nagashima Y, Hirahara F, Miyazaki K (1998) Wide distribution of laminin-5 gamma 2 chain in basement membranes of various human tissues. Horm Res 50:7–14",{"doi":562},{"id":20,"text":699,"url":20,"identifiers":700},"Mygind H, Nielsen B, Moe D, Clausen H, Dabelsteen E, Clausen PP (1988) Antikeratin antibodies in routine diagnostic pathology. A comparison of 10 different commercial antikeratins. APMIS 96:1009–1022",{},{"id":702,"text":703,"url":704,"identifiers":705},"9081d2e8-6ccc-4e25-b293-ae79c62e56e8","Myoung H, Kim MJ, Hong SD, Lee JI, Lim CY, Hong SP (2002) Expression of membrane type I-matrix metalloproteinase in oral squamous cell carcinoma. Cancer Lett 185:201–209","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0304383502002811",{"doi":706},"10.1016\u002Fs0304-3835(02)00281-1",{"id":558,"text":708,"url":560,"identifiers":709},"Nakashima Y, Kariya Y, Yasuda C, Miyazaki K (2005) Regulation of cell adhesion and type VII collagen binding by the beta3 chain short arm of laminin-5: effect of its proteolytic cleavage. J Biochem (Tokyo) 138:539–552",{"doi":562},{"id":558,"text":711,"url":560,"identifiers":712},"Nikkari ST, Hoyhtya M, Isola J, Nikkari T (1996) Macrophages contain 92-kd gelatinase (MMP-9) at the site of degenerated internal elastic lamina in temporal arteritis. Am J Pathol 149: 1427–1433",{"doi":562},{"id":558,"text":714,"url":560,"identifiers":715},"Olsen J, Lefebvre O, Fritsch C, Troelsen JT, Orian-Rousseau V, Kedinger M, Simon-Assmann P (2000) Involvement of activator protein 1 complexes in the epithelium-specific activation of the laminin gamma2-chain gene promoter by hepatocyte growth factor (scatter factor). Biochem J 347:407–417",{"doi":562},{"id":558,"text":717,"url":560,"identifiers":718},"Ono Y, Nakanishi Y, Ino Y, Niki T, Yamada T, Yoshimura K, Saikawa M, Nakajima T, Hirohashi S (1999) Clinocopathologic significance of laminin-5 gamma2 chain expression in squamous cell carcinoma of the tongue: immunohistochemical analysis of 67 lesions. Cancer 85:2315–2321",{"doi":562},{"id":558,"text":720,"url":560,"identifiers":721},"Osborn M, Debus E, Weber K (1984) Monoclonal antibodies specific for vimentin. Eur J Cell Biol 34:137–143",{"doi":562},{"id":20,"text":723,"url":20,"identifiers":724},"Peinado H, Quintanilla M, Cano A (2003) Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J Biol Chem 278:21113–21123",{},{"id":20,"text":726,"url":20,"identifiers":727},"Prime SS, Davies M, Pring M, Paterson IC (2004) The role of TGF-beta in epithelial malignancy and its relevance to the pathogenesis of oral cancer (part II). Crit Rev Oral Biol Med 15:337–347",{},{"id":558,"text":729,"url":560,"identifiers":730},"Pyke C, Romer J, Kallunki P, Lund LR, Ralfkiaer E, Dano K, Tryggvason K (1994) The gamma 2 chain of kalinin\u002Flaminin 5 is preferentially expressed in invading malignant cells in human cancers. Am J Pathol 145:782–791",{"doi":562},{"id":558,"text":732,"url":560,"identifiers":733},"Pyke C, Salo S, Ralfkiaer E, Romer J, Dano K, Tryggvason K (1995) Laminin- 5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas. Cancer Res 55:4132–4139",{"doi":562},{"id":558,"text":735,"url":560,"identifiers":736},"Richter P, Böhmer FD, Hindermann W, Borsi L, Hyckel P, Schleier P, Katenkamp D, Kosmehl H, Berndt A (2005) Analysis of activated EGFR signaling pathways and their relation to laminin-5 gamma2 chain expression in oral squamous cell carcinoma (OSCC). Histochem Cell Biol 124:151–160",{"doi":562},{"id":558,"text":738,"url":560,"identifiers":739},"Rousselle P, Lunstrum GP, Keene DR, Burgeson RE (1991) Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments. J Cell Biol 114:567–576",{"doi":562},{"id":558,"text":741,"url":560,"identifiers":742},"Ryan MC, Tizard R, VanDevanter DR, Carter WG (1994) Cloning of the LamA3 gene encoding the alpha 3 chain of the adhesive ligand epiligrin. Expression in wound repair. J Biol Chem 269:22779–22787",{"doi":562},{"id":558,"text":744,"url":560,"identifiers":745},"Serini G, Bochaton-Piallat ML, Ropraz P, Geinoz A, Borsi L, Zardi L, Gabbiani G (1998) The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1. J Cell Biol 142:873–881",{"doi":562},{"id":558,"text":747,"url":560,"identifiers":748},"Shin SS, Liu C, Chang EY, Carlson CS, Di Cesare PE (2004) Expression of bone morphogenetic proteins by Dupuytren’s fibroblasts. J Hand Surg 29:809–814",{"doi":562},{"id":558,"text":750,"url":560,"identifiers":751},"Sordat I, Rousselle P, Chaubert P, Petermann O, Aberdam D, Bosman FT, Sordat B, (2000) Tumor cell budding and laminin-5 expression in colorectal carcinoma can be modulated by the tissue micro-environment. Int J Cancer 88:708–717",{"doi":562},{"id":558,"text":753,"url":560,"identifiers":754},"Stawowy P, Margeta C, Kallisch H, Seidah NG, Chretien M, Fleck E, Graf K (2004) Regulation of matrix metalloproteinase MT1-MMP\u002FMMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase. Cardiovasc Res 63:87–97",{"doi":562},{"id":558,"text":756,"url":560,"identifiers":757},"Tani T, Karttunen T, Kiviluoto T, Kivilaakso E, Burgeson RE, Sipponen P, Virtanen I (1996) Alpha 6 beta 4 integrin and newly deposited laminin-1 and laminin-5 form the adhesion mechanism of gastric carcinoma. Continuous expression of laminins but not that of collagen VII is preserved in invasive parts of the carcinomas: implications for acquisition of the invading phenotype. Am J Pathol 149:781–793",{"doi":562},{"id":558,"text":759,"url":560,"identifiers":760},"Tani T, Lumme A, Linnala A, Kivilaakso E, Kiviluoto T, Burgeson RE, Kangas L, Leivo I, Virtanen I (1997) Pancreatic carcinomas deposit laminin-5, preferably adhere to laminin-5, and migrate on the newly deposited basement membrane. Am J Pathol 151:1289–1302",{"doi":562},{"id":558,"text":762,"url":560,"identifiers":763},"Tsubota Y, Yasuda C, Kariya Y, Ogawa T, Hirosaki T, Mizushima H, Miyazaki K (2005) Regulation of biological activity and matrix assembly of laminin-5 by COOH-terminal, LG4–5 domain of alpha3 chain. J Biol Chem 280:14370–14377",{"doi":562},{"id":558,"text":765,"url":560,"identifiers":766},"Uraguchi M, Morikawa M, Shirakawa M, Sanada K, Imai K (2003) Activation of WNT family expression and signalling in squamous cell carcinomas of the oral cavity. J Dent Res 83:327–332",{"doi":562},{"id":558,"text":768,"url":560,"identifiers":769},"Vailly J, Verrando P, Champliaud MF, Gerecke D, Wagman DW, Baudoin C, Aberdam D, Burgeson R, Bauer E, Ortonne JP (1994) The 100-kDa chain of nicein\u002Fkalinin is a laminin B2 chain variant. Eur J Biochem 219:209–218",{"doi":562},{"id":558,"text":771,"url":560,"identifiers":772},"Zhang W, Matrisian LM, Holmbeck K, Vick CC, Rosenthal EL (2006) Fibroblast-derived MTI-MMP promotes tumor progression in vitro and in vivo. BMC Cancer 6:52",{"doi":562},{"id":774,"createTime":775,"updateTime":776,"relativeEntities":777,"slug":778,"properties":779,"entityType":203,"verifyStatus":204,"verifyTime":790,"verifyNote":206,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":791,"fullTextUrl":20,"authors":792,"publicationType":276,"publisherRelationship":925,"citationCount":120,"citationInfo":985,"publishDate":988,"publishYear":986,"citationAnalyzeStatus":19,"lastCitationAnalyze":989,"indexDatabases":990,"openAccess":20,"references":20,"isForceReanalyzing":345},"50c2065b-162e-4b31-808c-68b5aeffdbf6","2024-01-18T07:46:46.542+00:00","2026-07-13T15:40:19.164+00:00",[],"Tension-force-induced-bone-formation-in-orthodontic-tooth-movement-via-modulation-of-the-GSK-3%CE%B2-%CE%B2-catenin-signaling-pathway",{"abstract":780,"title":782,"gsPaper":784,"references":786,"doi":788},{"EN":781},"Orthodontic force-induced osteogenic differentiation and bone formation at tension sites play a critical role in orthodontic tooth movement. However, the molecular mechanism underlying this phenomenon is poorly understood. In the current study, we investigated the involvement of the GSK-3β\u002Fβ-catenin signaling pathway, which is critical for bone formation during tooth movement. We established a rat tooth movement model to test the hypothesis that orthodontic force may stimulate bone formation at the tension site of the moved tooth and promote the rate of tooth movement via regulation of the GSK-3β\u002Fβ-catenin signaling pathway. Our results showed that continued mechanical loading increased the distance between the first and second molar in rats. In addition, the loading force increased bone formation at the tension site, and also increased phospho-Ser9-GSK-3β expression and β-catenin signaling pathway activity. Downregulation of GSK-3β activity further increased bone parameters, including bone mineral density, bone volume to tissue volume and trabecular thickness, as well as ALP- and osterix-positive cells at tension sites during tooth movement. However, ICG-001, the β-catenin selective inhibitor, reversed the positive effects of GSK-3β inhibition. In addition, pharmaceutical inhibition of GSK-3β or local treatment with β-catenin inhibitor did not influence the rate of tooth movement. Based on these results, we concluded that GSK-3β\u002Fβ-catenin signaling contributes to the bone remodeling induced by orthodontic forces, and can be used as a potential therapeutic target in clinical dentistry.",{"EN":783},"Tension force-induced bone formation in orthodontic tooth movement via modulation of the GSK-3β\u002Fβ-catenin signaling pathway",{"VOID":785},"[\"10458331205467395185\"]",{"VOID":787},"Aksu M, Saglam-Aydinatay B, Akcan CA, El H, Taner T, Kocadereli I, Tuncbilek G, Mavili ME (2010) Skeletal and dental stability after maxillary distraction with a rigid external device in adult cleft lip and palate patients. J Oral Maxillofac Surg 68:254–259\nChen X, Hu C, Wang G, Li L, Kong X, Ding Y, Jin Y (2013) Nuclear factor-κB modulates osteogenesis of periodontal ligament stem cells through competition with β-catenin signaling in inflammatory microenvironments. Cell Death Dis 4:e510\nChung CJ, Baik HS, Soma K (2007) Bone formation and tooth movement are synergistically enhanced by administration of EP4 agonist. Am J Orthod Dentofacial Orthop 132:427.e13–427.e20\nClément-Lacroix P, Ai M, Morvan F, Roman-Roman S, Vayssière B, Belleville C, Estrera K, Warman ML, Baron R, Rawadi G (2005) Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc Natl Acad Sci USA 102:17406–17411\nClevers H, Nusse R (2012) Wnt\u002Fβ-catenin signaling and disease. Cell 149:1192–1205\nCui J, Li J, Wang W, Han X, Du J, Sun J, Feng W, Liu B, Liu H, Amizuka N, Li M (2016) The effect of calcitriol on high mobility group box 1 expression in periodontal ligament cells during orthodontic tooth movement in rats. J Mol Histol 47(2):221–228\nDai Q, Zhou S, Zhang P, Ma X, Ha N, Yang X, Yu Z, Fang B, Jiang L (2017) Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats. Sci Rep 7:3906\nFu HD, Wang BK, Wan ZQ, Lin H, Chang ML, Han GL (2016) Wnt5a mediated canonical Wnt signaling pathway activation in orthodontic tooth movement: possible role in the tension force-induced bone formation. J Mol Histol 47:455–466\nGeng D, Wu J, Shao H, Zhu S, Wang Y, Zhang W, Ping Z, Hu X, Zhu X, Xu Y, Yang H (2015) Pharmaceutical inhibition of glycogen synthetase kinase 3 beta suppresses wear debris-induced osteolysis. Biomaterials 69:12–21\nGordon MD, Nusse R (2006) Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 281:22429–22433\nGu Q, Guo S, Wang D, Zhou T, Wang L, Wang Z, Ma J (2017a) Effect of corticision on orthodontic tooth movement in a rat model as assessed by RNA sequencing. J Mol Histol 48:199–208\nGu Y, Wang Z, Shi J, Wang L, Hou Z, Guo X, Tao Y, Wu X, Zhou W, Liu Y, Zhang W, Xu Y, Yang H, Xue F, Geng D (2017b) Titanium particle-induced osteogenic inhibition and bone destruction are mediated by the GSK-3β\u002Fβ-catenin signal pathway. Cell Death Dis 8:e2878\nJang HD, Shin JH, Park DR, Hong JH, Yoon K, Ko R, Ko CY, Kim HS, Jeong D, Kim N, Lee SY (2011) Inactivation of glycogen synthase kinase-3β is required for osteoclast differentiation. J Biol Chem 286:39043–39050\nKariya T, Tanabe N, Shionome C, Manaka S, Kawato T, Zhao N, Maeno M, Suzuki N, Shimizu N (2015) Tension force-induced ATP promotes osteogenesis through P2 × 7 receptor in osteoblasts. J Cell Biochem 116:12–21\nKrause U, Harris S, Green A, Ylostalo J, Zeitouni S, Lee N, Gregory CA (2010) Pharmaceutical modulation of canonical Wnt signaling in multipotent stromal cells for improved osteoinductive therapy. Proc Natl Acad Sci USA 107:4147–4152\nLiu O, Xu J, Ding G, Liu D, Fan Z, Zhang C, Chen W, Ding Y, Tang Z, Wang S (2013) Periodontal ligament stem cells regulate B lymphocyte function via programmed cell death protein 1. Stem Cells 31:1371–1382\nLiu Y, Zhang T, Zhang C, Jin SS, Yang RL, Wang XD, Jiang N, Gan YH, Kou XX, Zhou YH (2017a) Aspirin blocks orthodontic relapse via inhibition of CD4 + T lymphocytes. J Dent Res 96:586–594\nLiu F, Wen F, He D, Liu D, Yang R, Wang X, Yan Y, Liu Y, Kou X, Zhou Y (2017b) Force-Induced H2S by PDLSCs Modifies Osteoclastic Activity during Tooth Movement. J Dent Res 96:694–702\nLiu L, Liu M, Li R, Liu H, Du L, Chen H, Zhang Y, Zhang S, Liu D (2017c) MicroRNA-503-5p inhibits stretch-induced osteogenic differentiation and bone formation. Cell Biol Int 41:112–123\nMabuchi R, Matsuzaka K, Shimono M (2002) Cell proliferation and cell death in periodontal ligaments during orthodontic tooth movement. J Periodontal Res 37:118–124\nMarsell R, Sisask G, Nilsson Y, Sundgren-Andersson AK, Andersson U, Larsson S, Nilsson O, Ljunggren O, Jonsson KB (2012) GSK-3 inhibition by an orally active small molecule increases bone mass in rats. Bone 50:619–627\nNakamura Y, Noda K, Shimoda S, Oikawa T, Arai C, Nomura Y, Kawasaki K (2008) Time-lapse observation of rat periodontal ligament during function and tooth movement, using microcomputed tomography. Eur J Orthod 30:320–326\nNoh T, Gabet Y, Cogan J, Shi Y, Tank A, Sasaki T, Criswell B, Dixon A, Lee C, Tam J, Kohler T, Segev E, Kockeritz L, Woodgett J, Müller R, Chai Y, Smith E, Bab I, Frenkel B (2009) Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner. PLoS ONE 4:e5438\nPazzini CA, Pereira LJ, da Silva TA, Montalvany-Antonucci CC, Macari S, Marques LS, de Paiva SM (2017) Probiotic consumption decreases the number of osteoclasts during orthodontic movement in mice. Arch Oral Biol 79:30–34\nPremaraj S, Souza I, Premaraj T (2011) Mechanical loading activates β-catenin signaling in periodontal ligament cells. Angle Orthod 81:592–599\nQin J, Hua Y (2016) Effects of hydrogen sulfide on the expression of alkaline phosphatase, osteocalcin and collagen type I in human periodontal ligament cells induced by tension force stimulation. Mol Med Rep 14:3871–3877\nSun J, Du J, Feng W, Lu B, Liu H, Guo J, Amizuka N, Li M (2017) Histological evidence that metformin reverses the adverse effects of diabetes on orthodontic tooth movement in rats. J Mol Histol 48(2):73–81\nTsuge A, Noda K, Nakamura Y (2016) Early tissue reaction in the tension zone of PDL during orthodontic tooth movement. Arch Oral Biol 65:17–25\nVerna C, Zaffe D, Siciliani G (1999) Histomorphometric study of bone reactions during orthodontic tooth movement in rats. Bone 24:371–379\nVestergaard P, Rejnmark L, Mosekilde L (2005) Reduced relative risk of fractures among users of lithium. Calcif Tissue Int 77:1–8\nWang Y, Gao S, Jiang H, Lin P, Bao X, Zhang Z, Hu M (2014) Lithium chloride attenuates root resorption during orthodontic tooth movement in rats. Exp Ther Med 7:468–472\nWang C, Gu W, Sun B, Zhang Y, Ji Y, Xu X, Wen Y (2017) CTHRC1 promotes osteogenic differentiation of periodontal ligament stem cells by regulating TAZ. J Mol Histol 48(4):311–319\nZhong Z, Zylstra-Diegel CR, Schumacher CA, Baker JJ, Carpenter AC, Rao S, Yao W, Guan M, Helms JA, Lane NE, Lang RA, Williams BO (2012) Wntless functions in mature osteoblasts to regulate bone mass. Proc Natl Acad Sci USA 109:E2197–E2204",{"VOID":789},"10.1007\u002Fs10735-017-9748-x","2024-05-10T15:35:59.436+00:00","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs10735-017-9748-x",[793,817,832,845,858,873,886,899,912],{"id":794,"sortIndex":21,"researcher":20,"roles":795,"affiliations":796,"properties":814,"displayName":816,"givenName":20,"familyName":20},"e0c9df90-3dfb-4919-b460-67bd4d2e6398",[212],[797,805],{"id":798,"sortIndex":21,"affiliation":799,"properties":20},"b4300c63-6f9d-4514-9ecd-cb285f78bd95",{"id":798,"createTime":20,"updateTime":20,"relativeEntities":800,"slug":20,"properties":801,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":804,"statistic":20},[],{"title":802},{"VI":803},"Nanjing Medical University, Nanjing, People’s Republic of 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(OA) remains a challenging condition due to limited drug bioavailability within the avascular and dense cartilage matrix. This study introduces a pH\u002Fredox-responsive nanogel for enhanced delivery of geraniol in OA therapy. We investigated geraniol's role in preventing chondrocyte matrix degradation and designed a pH\u002Fredox-responsive nanogel as a delivery platform. Our methods included Western blot, histological staining, and immunohistochemistry. Geraniol treatment reduced Keap1 expression while elevating Nrf2 and HO-1 levels, effectively inhibiting cartilage matrix degradation. The pH\u002Fredox-responsive nanogel further enhanced geraniol’s therapeutic impact. Our study demonstrates that geraniol encapsulated within a pH\u002Fredox-responsive nanogel mitigates OA by regulating oxidative stress and inflammation. This innovative approach holds potential as an effective OA therapeutic strategy.",{"EN":1001},"Intra-articular delivery of geraniol encapsulated by pH\u002Fredox-responsive nanogel ameliorates osteoarthritis by regulating oxidative stress and inflammation",{"VOID":1003},"[\"6092310877937045250\"]",{"VOID":1005},"Ansari MY, Ahmad N, Haqqi TM (2020) Oxidative stress and inflammation in osteoarthritis pathogenesis: role of polyphenols. Biomed Pharmacother 129:110452. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.biopha.2020.110452\nBedingfield SK, Colazo JM, Yu F, Liu DD, Jackson MA, Himmel LE et al (2021) Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage. Nat Biomed Eng 5(9):1069–1083. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41551-021-00780-3\nChang MC, Chiang PF, Kuo YJ, Peng CL, Chen KY, Chiang YC (2021) Hyaluronan-loaded liposomal dexamethasone-diclofenac nanoparticles for local osteoarthritis treatment. Int J Mol Sci. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fijms22020665\nChen P, Xia C, Mei S, Wang J, Shan Z, Lin X, Fan S (2016) Intra-articular delivery of sinomenium encapsulated by chitosan microspheres and photo-crosslinked GelMA hydrogel ameliorates osteoarthritis by effectively regulating autophagy. Biomaterials 81:1–13. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.biomaterials.2015.12.006\nCho M, So I, Chun JN, Jeon JH (2016) The antitumor effects of geraniol: modulation of cancer hallmark pathways (review). Int J Oncol 48(5):1772–1782. https:\u002F\u002Fdoi.org\u002F10.3892\u002Fijo.2016.3427\nFronza BM, Rad IY, Shah PK, Barros MD, Giannini M, Stansbury JW (2019) Nanogel-based filler-matrix interphase for polymerization stress reduction. J Dent Res 98(7):779–785. https:\u002F\u002Fdoi.org\u002F10.1177\u002F0022034519845843\nGautam D, Pedler MG, Nair DP, Petrash JM (2021) Nanogel-facilitated in-situ delivery of a cataract inhibitor. Biomolecules. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fbiom11081150\nGuhaSarkar S, Pathak K, Sudhalkar N, More P, Goda JS, Gota V, Banerjee R (2016) Synergistic locoregional chemoradiotherapy using a composite liposome-in-gel system as an injectable drug depot. Int J Nanomedicine 11:6435–6448. https:\u002F\u002Fdoi.org\u002F10.2147\u002FIJN.S110525\nGuilak F, Nims RJ, Dicks A, Wu CL, Meulenbelt I (2018) Osteoarthritis as a disease of the cartilage pericellular matrix. Matrix Biol 71–72:40–50. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.matbio.2018.05.008\nHan Y, Yang J, Zhao W, Wang H, Sun Y, Chen Y et al (2021) Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis. Bioact Mater 6(10):3596–3607. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.bioactmat.2021.03.022\nHu Y, Chen X, Wang S, Jing Y, Su J (2021) Subchondral bone microenvironment in osteoarthritis and pain. Bone Res 9(1):20. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41413-021-00147-z\nHuang K, Wu LD (2008) Aggrecanase and aggrecan degradation in osteoarthritis: a review. J Int Med Res 36(6):1149–1160. https:\u002F\u002Fdoi.org\u002F10.1177\u002F147323000803600601\nJin Z, Chang B, Wei Y, Yang Y, Zhang H, Liu J et al (2022) Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK\u002FPINK1\u002FParkin-mediated mitophagy. Biomed Pharmacother 151:113092. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.biopha.2022.113092\nJones IA, Togashi R, Wilson ML, Heckmann N, Vangsness CT Jr (2019) Intra-articular treatment options for knee osteoarthritis. Nat Rev Rheumatol 15(2):77–90. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41584-018-0123-4\nKang DG, Lee HJ, Kim KT, Hwang SC, Lee CJ, Park JS (2017) Effect of oleanolic acid on the activity, secretion and gene expression of matrix metalloproteinase-3 in articular chondrocytes in vitro and the production of matrix metalloproteinase-3 in vivo. Korean J Physiol Pharmacol 21(2):197–204. https:\u002F\u002Fdoi.org\u002F10.4196\u002Fkjpp.2017.21.2.197\nLi Z, Huang Z, Bai L (2021) Cell interplay in osteoarthritis. Front Cell Dev Biol 9:720477. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffcell.2021.720477\nLi J, Jiang M, Yu Z, Xiong C, Pan J, Cai Z et al (2022a) Artemisinin relieves osteoarthritis by activating mitochondrial autophagy through reducing TNFSF11 expression and inhibiting PI3K\u002FAKT\u002FmTOR signaling in cartilage. Cell Mol Biol Lett 27(1):62. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs11658-022-00365-1\nLi M, Yin H, Yan Z, Li H, Wu J, Wang Y et al (2022b) The immune microenvironment in cartilage injury and repair. Acta Biomater 140:23–42. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.actbio.2021.12.006\nLin L, Long N, Qiu M, Liu Y, Sun F, Dai M (2021a) The inhibitory efficiencies of geraniol as an anti-inflammatory, antioxidant, and antibacterial, natural agent against methicillin-resistant Staphylococcus aureus infection in vivo. Infect Drug Resist 14:2991–3000. https:\u002F\u002Fdoi.org\u002F10.2147\u002FIDR.S318989\nLin Y, Li C, Liu A, Zhen X, Gao J, Wu W et al (2021b) Responsive hyaluronic acid-gold cluster hybrid nanogel theranostic systems. Biomater Sci 9(4):1363–1373. https:\u002F\u002Fdoi.org\u002F10.1039\u002Fd0bm01815e\nMa T, Jia L, Zhao J, Lv L, Yu Y, Ruan H et al (2022) Ginkgolide C slows the progression of osteoarthritis by activating Nrf2\u002FHO-1 and blocking the NF-kappaB pathway. Front Pharmacol 13:1027553. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffphar.2022.1027553\nMaczka W, Winska K, Grabarczyk M (2020) One hundred faces of geraniol. Molecules. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fmolecules25143303\nMandl LA (2019) Osteoarthritis year in review 2018: clinical. Osteoarthr Cartil 27(3):359–364. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.joca.2018.11.001\nMartel-Pelletier J, Barr AJ, Cicuttini FM, Conaghan PG, Cooper C, Goldring MB et al (2016) Osteoarthritis. Nat Rev Dis Primers 2:16072. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fnrdp.2016.72\nMlost J, Kac P, Kedziora M, Starowicz K (2022) Antinociceptive and chondroprotective effects of prolonged beta-caryophyllene treatment in the animal model of osteoarthritis: focus on tolerance development. Neuropharmacology 204:108908. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.neuropharm.2021.108908\nPalazzo C, Nguyen C, Lefevre-Colau MM, Rannou F, Poiraudeau S (2016) Risk factors and burden of osteoarthritis. Ann Phys Rehabil Med 59(3):134–138. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.rehab.2016.01.006\nPavan B, Dalpiaz A, Marani L, Beggiato S, Ferraro L, Canistro D et al (2018) Geraniol pharmacokinetics, bioavailability and its multiple effects on the liver antioxidant and xenobiotic-metabolizing enzymes. Front Pharmacol 9:18. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffphar.2018.00018\nPeat G, Thomas MJ (2021) Osteoarthritis year in review 2020: epidemiology & therapy. Osteoarthr Cartil 29(2):180–189. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.joca.2020.10.007\nPereira D, Ramos E, Branco J (2015) Osteoarthritis. Acta Med Port 28(1):99–106. https:\u002F\u002Fdoi.org\u002F10.20344\u002Famp.5477\nRibovski L, de Jong E, Mergel O, Zu G, Keskin D, van Rijn P, Zuhorn IS (2021) Low nanogel stiffness favors nanogel transcytosis across an in vitro blood-brain barrier. Nanomedicine 34:102377. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.nano.2021.102377\nScanzello CR, Goldring SR (2012) The role of synovitis in osteoarthritis pathogenesis. Bone 51(2):249–257. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.bone.2012.02.012\nSun W, Yue M, Xi G, Wang K, Sai J (2022) Knockdown of NEK7 alleviates anterior cruciate ligament transection osteoarthritis (ACLT)-induced knee osteoarthritis in mice via inhibiting NLRP3 activation. Autoimmunity 55(6):398–407. https:\u002F\u002Fdoi.org\u002F10.1080\u002F08916934.2022.2093861\nTang Q, Zheng G, Feng Z, Chen Y, Lou Y, Wang C et al (2017) Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development. Cell Death Dis 8(10):e3081. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fcddis.2017.453\nTao SC, Huang JY, Gao Y, Li ZX, Wei ZY, Dawes H, Guo SC (2021) Small extracellular vesicles in combination with sleep-related circRNA3503: a targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis. Bioact Mater 6(12):4455–4469. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.bioactmat.2021.04.031\nThomas AC, Hubbard-Turner T, Wikstrom EA, Palmieri-Smith RM (2017) Epidemiology of posttraumatic osteoarthritis. J Athl Train 52(6):491–496. https:\u002F\u002Fdoi.org\u002F10.4085\u002F1062-6050-51.5.08\nWang FS, Kuo CW, Ko JY, Chen YS, Wang SY, Ke HJ et al (2020) Irisin mitigates oxidative stress chondrocyte dysfunction and osteoarthritis development through regulating mitochondrial integrity and autophagy. Antioxidants (basel). https:\u002F\u002Fdoi.org\u002F10.3390\u002Fantiox9090810\nWang Y, Ge W, Ma Z, Ji G, Wang M, Zhou G, Wang X (2022) Use of mesoporous polydopamine nanoparticles as a stable drug-release system alleviates inflammation in knee osteoarthritis. APL Bioeng 6(2):026101. https:\u002F\u002Fdoi.org\u002F10.1063\u002F5.0088447\nYounis NS, Abduldaium MS, Mohamed ME (2020) Protective effect of geraniol on oxidative, inflammatory and apoptotic alterations in isoproterenol-induced cardiotoxicity: role of the Keap1\u002FNrf2\u002FHO-1 and PI3K\u002FAkt\u002FmTOR pathways. Antioxidants (basel). https:\u002F\u002Fdoi.org\u002F10.3390\u002Fantiox9100977\nYounis NS, Elsewedy HS, Shehata TM, Mohamed ME (2021) Geraniol averts methotrexate-induced acute kidney injury via Keap1\u002FNrf2\u002FHO-1 and MAPK\u002FNF-kappaB pathways. Curr Issues Mol Biol 43(3):1741–1755. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fcimb43030123\nZahan OM, Serban O, Gherman C, Fodor D (2020) The evaluation of oxidative stress in osteoarthritis. Med Pharm Rep 93(1):12–22. https:\u002F\u002Fdoi.org\u002F10.15386\u002Fmpr-1422\nZhang T, Yang R, Yang S, Guan J, Zhang D, Ma Y, Liu H (2018) Research progress of self-assembled nanogel and hybrid hydrogel systems based on pullulan derivatives. Drug Deliv 25(1):278–292. https:\u002F\u002Fdoi.org\u002F10.1080\u002F10717544.2018.1425776\nZhang YF, Huang Y, Ni YH, Xu ZM (2019) Systematic elucidation of the mechanism of geraniol via network pharmacology. Drug Des Devel Ther 13:1069–1075. https:\u002F\u002Fdoi.org\u002F10.2147\u002FDDDT.S189088\nZheng L, Zhang Z, Sheng P, Mobasheri A (2021) The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis. Ageing Res Rev 66:101249. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.arr.2020.101249",{"VOID":1007},"10.1007\u002Fs10735-023-10163-4","2024-05-16T06:22:09.490+00:00","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs10735-023-10163-4",[1011,1026,1039,1052],{"id":1012,"sortIndex":21,"researcher":20,"roles":1013,"affiliations":1014,"properties":1023,"displayName":1025,"givenName":20,"familyName":20},"427bc0c3-6995-42a0-9a70-867be812a51d",[212],[1015],{"id":1016,"sortIndex":21,"affiliation":1017,"properties":20},"2a52883e-4fc1-4457-89ce-badcc33e8974",{"id":1016,"createTime":20,"updateTime":20,"relativeEntities":1018,"slug":20,"properties":1019,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1022,"statistic":20},[],{"title":1020},{"VI":1021},"Department of Orthopedics, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 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integrity of the regenerated tissues requires not only structural integrity but also vascularization and innervation. We previously demonstrated that the three-dimensional (3D) reconstructed eccrine sweat glands had similar structures as those of the native ones did, but whether the 3D reconstructed glands possessing vascularization and innervation was still unknown. In the study, Matrigel-embedded eccrine sweat gland cells were implanted under the inguinal skin. Ten weeks post-implantation, the vascularization, and innervation in the 10-week reconstructed eccrine sweat glands and native human eccrine sweat glands were detected by immunofluorescence staining. The results showed that the fluorescent signals of general neuronal marker protein gene product 9.5, adrenergic nerve fiber marker tyrosine hydroxylase, and cholinergic nerve fiber markers acetylcholinesterase and vasoactive intestinal peptide embraced the 3D reconstructed glands in circular patterns, as the signals appeared in native eccrine sweat glands. There were many CD31- and von Willebrand factor-positive vessels growing into the plugs. We demonstrated that the 3D reconstructed eccrine sweat glands were nourished by blood vessels, and we for the first time demonstrated that the engineering sweat glands were innervated by both cholinergic and adrenergic fibers. In conclusion, the 3D reconstructed eccrine sweat glands may have functions as the native ones do.",{"EN":1142},"Three-dimensional reconstructed eccrine sweat glands with vascularization and cholinergic and adrenergic innervation",{"VOID":1144},"[\"3538904012130372767\"]",{"VOID":1146},"Cowen T, Thrasivoulou C, Shaw SA, Abdel-Rahman TA (1996) Transplanted sweat glands from mature and aged donors determine cholinergic phenotype and altered density of host sympathetic nerves. J Auton Nerv Syst 60:215–224\nDanner S, Kremer M, Petschnik AE, Nagel S, Zhang Z, Hopfner U, Reckhenrich AK, Weber C, Schenck TL, Becker T, Kruse C, Machens HG, Egana JT (2012) The use of human sweat gland-derived stem cells for enhancing vascularization during dermal regeneration. J Invest Dermatol 132:1707–1716\nDistler JH, Hirth A, Kurowska-Stolarska M, Gay RE, Gay S, Distler O (2003) Angiogenic and angiostatic factors in the molecular control of angiogenesis. Q J Nucl Med 47:149–161\nFu X, Li X, Cheng B, Chen W, Sheng Z (2005a) Engineered growth factors and cutaneous wound healing: success and possible questions in the past 10 years. Wound Repair Regen 13:122–130\nFu XB, Sun TZ, Li XK, Sheng ZY (2005b) Morphological and distribution characteristics of sweat glands in hypertrophic scar and their possible effects on sweat gland regeneration. Chin Med J (Engl) 118:186–191\nGao LP, Du MJ, Lv JJ, Schmull S, Huang RT, Li J (2017) Use of human aortic extracellular matrix as a scaffold for construction of a patient-specific tissue engineered vascular patch. Biomed Mater 12:065006\nHuging M, Biedermann T, Sobrio M, Meyer S, Bottcher-Haberzeth S, Manuel E, Horst M, Hynes S, Reichmann E, Schiestl C, Hartmann-Fritsch F (2017) The effect of wound dressings on a bio-engineered human dermo-epidermal skin substitute in a rat model. J Burn Care Res 38:354–364\nKarsy M, Burnett B, Di Ieva A, Cusimano MD, Jensen RL (2018) Microvascularization of Grade I meningiomas: effect on tumor volume, blood loss, and patient outcome. J Neurosurg 128(3):657–666. https:\u002F\u002Fdoi.org\u002F10.3171\u002F2016.10.JNS161825\nKlar AS, Michalak K, Böttcher-Haberzeth S, Reichmann E, Meuli M, Biedermann T (2018) The expression pattern of keratin 24 in tissue-engineered dermo-epidermal human skin substitutes in an in vivo model. Pediatr Surg Int 34(2):237–244. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00383-017-4198-9\nLandis SC, Fredieu JR (1986) Coexistence of calcitonin gene-related peptide and vasoactive intestinal peptide in cholinergic sympathetic innervation of rat sweat glands. Brain Res 377:177–181\nLi H, Chen L, Zeng S, Li X, Zhang X, Lin C, Zhang M, Xie S, He Y, Shu S, Yang L, Tang S, Fu X (2015) Matrigel basement membrane matrix induces eccrine sweat gland cells to reconstitute sweat gland-like structures in nude mice. Exp Cell Res 332:67–77\nLi H, Li X, Zhang B, Zhang M, Chen W, Tang S, Fu X (2016a) Changes in keratins and alpha-smooth muscle actin during three-dimensional reconstitution of eccrine sweat glands. Cell Tissue Res 365:113–122\nLi H, Zhang M, Chen L, Li X, Zhang B (2016b) Human eccrine sweat gland cells reconstitute polarized spheroids when subcutaneously implanted with Matrigel in nude mice. J Mol Histol 47:485–490\nLi H, Chen L, Zhang M, Zhang B (2017a) Foxa1 gene and protein in developing rat eccrine sweat glands. J Mol Histol 48:1–7\nLi H, Zhang M, Chen L, Zhang B, Zhang C (2017b) Expression of S100A2 and S100P in human eccrine sweat glands and their application in differentiating secretory coil-like from duct-like structures in the 3D reconstituted eccrine sweat spheroids. J Mol Histol 48:219–223\nLi X, Li H, Zhang M, Chen L, Zhang B (2017c) Cell proliferation and differentiation during the three dimensional reconstitution of eccrine sweat glands. J Mol Histol 48:113–120\nLu CP, Polak L, Keyes BE, Fuchs E (2016) Spatiotemporal antagonism in mesenchymal-epithelial signaling in sweat versus hair fate decision. Science 354(6319):aah6102. https:\u002F\u002Fdoi.org\u002F10.1126\u002Fscience.aah6102\nRittie L, Sachs DL, Orringer JS, Voorhees JJ, Fisher GJ (2013) Eccrine sweat glands are major contributors to reepithelialization of human wounds. Am J Pathol 182:163–171\nSaga K (2002) Structure and function of human sweat glands studied with histochemistry and cytochemistry. Prog Histochem Cytochem 37:323–386\nSchotzinger RJ, Landis SC (1990) Acquisition of cholinergic and peptidergic properties by sympathetic innervation of rat sweat glands requires interaction with normal target. Neuron 5:91–100\nSchotzinger R, Yin X, Landis S (1994) Target determination of neurotransmitter phenotype in sympathetic neurons. J Neurobiol 25:620–639\nSheng Z, Fu X, Cai S, Lei Y, Sun T, Bai X, Chen M (2009) Regeneration of functional sweat gland-like structures by transplanted differentiated bone marrow mesenchymal stem cells. Wound Repair Regen 17:427–435\nStanke M, Duong CV, Pape M, Geissen M, Burbach G, Deller T, Gascan H, Otto C, Parlato R, Schutz G, Rohrer H (2006) Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp 130 signaling. Development 133:141–150\nStevens LM, Landis SC (1987) Development and properties of the secretory response in rat sweat glands: relationship to the induction of cholinergic function in sweat gland innervation. Dev Biol 123:179–190\nStevens LM, Landis SC (1988) Developmental interactions between sweat glands and the sympathetic neurons which innervate them: effects of delayed innervation on neurotransmitter plasticity and gland maturation. Dev Biol 130:703–720\nUno H, Hokfelt T (1975) Catecholamine-containing nerve terminals of the eccrine sweat glands of macaques. Cell Tissue Res 158:1–13\nWang N, Gibbons CH, Freeman R (2011) Novel immunohistochemical techniques using discrete signal amplification systems for human cutaneous peripheral nerve fiber imaging. J Histochem Cytochem 59:382–390\nWatt SM, Pleat JM (2018) Stem cells, niches and scaffolds: applications to burns and wound care. Adv Drug Deliv Rev 123:82–106. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.addr.2017.10.012\nZhang C, Chen Y, Fu X (2015) Sweat gland regeneration after burn injury: is stem cell therapy a new hope? 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The epididymis has three distinct regions known as caput, corpus, and cauda. The transit through the epididymis is an essential process in sperm maturation. The lumen of each epididymal region has a unique fluid composition regulated by many ion channels and transporters in the epithelial cells. The objective of this study was to map the sites of localization of ion channels ENaC and CFTR along the length of the mouse and rat epididymis using confocal microscopic imaging. The integrity of the fine structure of the tissues was verified by fluorescent phalloidin staining of actin filaments visualized by high-resolution confocal microscopy. The 2D and 3D images showed preservation of the stereocilia. Based on these images we determined morphometric parameters of the epithelial cells and ducts. ENaC and CFTR immunofluorescence appeared almost continuously on the apical membrane of caput and in smooth muscle myoid cells. In cauda, CFTR expression was observed continuously in long stretches of epithelium interrupted by clusters of cells that showed no CFTR expression. Similar patterns of localization were observed in both mouse and rat samples. Mutations in the CFTR gene are known to result in male infertility. Based on the widespread presence of ENaC along the epididymis we suggest that mutations in ENaC subunits may also be associated with male infertility. The diverse phenotypes associated with CFTR mutations may be due to malfunction of CFTR at specific subcellular locations in the male reproductive system.",{"EN":1307},"Mapping the sites of localization of epithelial sodium channel (ENaC) and CFTR in segments of the mammalian 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Yelick",{"VOID":1692},"A5068312032",{"url":20,"publisher":1694,"properties":20},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1695,"slug":10,"properties":1696,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1700,"manageAffiliations":1717,"indexDatabases":1728,"url":101,"thumbnailPath":20,"statistic":1743,"gsStatistic":20,"type":181,"analyzePriority":20},[],{"issn":1697,"title":1698,"eissn":1699},{"VOID":13},{"EN":15},{"VOID":17},[1701,1705,1709,1713],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":1702,"label":1703,"description":1704,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},{"id":30,"createTime":20,"updateTime":20,"relativeEntities":1706,"label":1707,"description":1708,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":33},{},{"id":36,"createTime":20,"updateTime":20,"relativeEntities":1710,"label":1711,"description":1712,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":39},{},{"id":42,"createTime":20,"updateTime":20,"relativeEntities":1714,"label":1715,"description":1716,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":45},{},[1718,1723],{"id":49,"createTime":20,"updateTime":20,"relativeEntities":1719,"slug":20,"properties":1720,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1722,"statistic":20},[],{"title":1721},{"EN":53},[],{"id":56,"createTime":20,"updateTime":20,"relativeEntities":1724,"slug":20,"properties":1725,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1727,"statistic":20},[],{"title":1726},{"EN":60},[62],[1729,1736],{"id":65,"indexDatabase":1730,"url":76,"indexYears":77,"academicFieldIds":1735,"indexDatabaseRanking":83},{"id":67,"createTime":20,"updateTime":20,"relativeEntities":1731,"label":1732,"description":1733,"key":73,"publicationTags":1734,"standard":20},[],{"EN":70,"VI":70},{"EN":70,"VI":72},[75],[79,80,81,82],{"id":85,"indexDatabase":1737,"url":98,"indexYears":20,"academicFieldIds":1742,"indexDatabaseRanking":20},{"id":87,"createTime":20,"updateTime":20,"relativeEntities":1738,"label":1739,"description":1740,"key":94,"publicationTags":1741,"standard":20},[],{"EN":90,"VI":90},{"EN":92,"VI":93},[96,97],[100],{"impactFactor":21,"impactFactorByYear":1744,"i10Index":115,"i10IndexLast5Year":116,"totalPublication":117,"totalPublicationByYear":1745,"totalCitation":137,"totalCitationByYear":1746,"totalCitationPerPublication":158,"totalCitationPerPublicationByYear":1747,"hindexLast5Year":120,"hindex":120},{"2011":104,"2012":105,"2013":106,"2014":107,"2015":108,"2016":109,"2017":110,"2018":111,"2019":108,"2020":112,"2021":113,"2022":114,"2023":114},{"2003":116,"2004":119,"2005":120,"2006":121,"2007":122,"2008":123,"2009":124,"2010":125,"2011":126,"2012":127,"2013":127,"2014":128,"2015":129,"2016":130,"2017":131,"2018":128,"2019":132,"2020":119,"2021":133,"2022":134,"2023":135,"2024":136},{"2003":139,"2004":140,"2005":141,"2006":142,"2007":143,"2008":144,"2009":145,"2010":146,"2011":147,"2012":148,"2013":149,"2014":150,"2015":151,"2016":152,"2017":151,"2018":153,"2019":154,"2020":155,"2021":156,"2022":125,"2023":157},{"2003":160,"2004":161,"2005":162,"2006":163,"2007":164,"2008":165,"2009":166,"2010":167,"2011":168,"2012":169,"2013":170,"2014":171,"2015":172,"2016":173,"2017":174,"2018":175,"2019":176,"2020":177,"2021":178,"2022":179,"2023":180},17,{"total":1748,"publishYear":1750,"statisticByYear":1751},2012,{"2014":227,"2015":431,"2016":241,"2017":340,"2018":241,"2020":227,"2022":241},"2012-02-01",[96,83],[1755,1758,1762,1766,1770,1774,1778,1782,1786,1790,1794,1798,1802,1806,1810,1814,1818,1822,1826,1830,1834,1838,1842,1846,1850,1854,1858,1862,1866,1870],{"id":20,"text":1756,"url":20,"identifiers":1757},"Andrews PW ((2004)) Author replay in comments. Nat Biotechnol 22:381–382",{},{"id":20,"text":1759,"url":20,"identifiers":1760},"Benn PA (1977) Population kinetics of chromosomally abnormal human fibroblast subpopulations. Cytogenet Cell Genet 19:136–145",{"doi":1761},"10.1159\u002F000130804",{"id":20,"text":1763,"url":20,"identifiers":1764},"Bochkov NP, Voronina ES, Kosyakova NV, Liehr T, Rzhaninova AA, Katosova LD, Platonova VI, Gol’dshtein DV (2007) Chromosome variability of human multipotent mesenchymal stromal cells. Bull Exp Biol Med 143:122–126",{"doi":1765},"10.1007\u002Fs10517-007-0031-0",{"id":20,"text":1767,"url":20,"identifiers":1768},"Buzzard JJ, Gough NM, Crook JM, Colman A (2004) Karyotype of human ES cells during extended culture. Nat Biotechnol 22:381–382",{"doi":1769},"10.1038\u002Fnbt0404-381",{"id":20,"text":1771,"url":20,"identifiers":1772},"Caisander G, Park H, Frej K, Lindqvist J, Bergh C, Lundin K, Hanson C (2006) Chromosomal integrity maintained in five human embryonic stem cell lines after prolonged in vitro culture. Chromosome Res 14:131–137",{"doi":1773},"10.1007\u002Fs10577-006-1019-8",{"id":20,"text":1775,"url":20,"identifiers":1776},"Carreira IM, Mascarenhas A, Matoso E, Couceiro AB, Ramos L, Dufke A, Mazauric M, Stressig R, Kosyakova N, Melo JB, Liehr T (2007) Three unusual but cytogenetically similar cases with up to five different cell lines involving structural and numerical abnormalities of chromosome 18. J Histochem Cytochem 55:1123–1128",{"doi":1777},"10.1369\u002Fjhc.7A7244.2007",{"id":20,"text":1779,"url":20,"identifiers":1780},"Catalina P, Cobo F, Cortés JL, Nieto AI, Cabrera C, Montes R, Concha A, Menendez P (2007) Conventional and molecular cytogenetic diagnostic methods in stem cell research: a concise review. Cell Biol Int 31:861–869",{"doi":1781},"10.1016\u002Fj.cellbi.2007.03.012",{"id":20,"text":1783,"url":20,"identifiers":1784},"Draper JS, Moore HD, Ruban LN, Gokhale PJ, Andrews PW (2004) Culture and characterization of human embryonic stem cells. Stem Cells Dev 13:325–336",{"doi":1785},"10.1089\u002Fscd.2004.13.325",{"id":20,"text":1787,"url":20,"identifiers":1788},"Duailibi MT, Duailibi SE, Young CS, Bartlett JD, Vacanti JP, Yelick PC (2004) Bioengineered teeth from cultured rat tooth bud cells. J Dent Res 83:517",{"doi":1789},"10.1177\u002F154405910408300701",{"id":20,"text":1791,"url":20,"identifiers":1792},"Duailibi MT, Duailibi SE, Duailibi Neto EF, Negreiros RM, Jorge WA, Ferreira LM, Vacanti JP, Yelick PC (2011) Tooth tissue engineering: optimal dental stem cell harvest based on tooth development. Artif Organs 35:129–135",{"doi":1793},"10.1111\u002Fj.1525-1594.2010.01200.x",{"id":20,"text":1795,"url":20,"identifiers":1796},"Forsyth NR, Musio A, Vezzoni P, Simpson AH, Noble BS, McWhir J (2006) Physiologic oxygen enhances human embryonic stem cell clonal recovery and reduces chromosomal abnormalities. Cloning Stem Cells 8(1):16–23",{"doi":1797},"10.1089\u002Fclo.2006.8.16",{"id":20,"text":1799,"url":20,"identifiers":1800},"Giraldo AM, Lynn JW, Godke RA, Bondioli KR (2006) Proliferative characteristics and chromosomal stability of bovine donor cells for nuclear transfer. Mol Reprod Dev 73:1230–1238",{"doi":1801},"10.1002\u002Fmrd.20558",{"id":20,"text":1803,"url":20,"identifiers":1804},"Hanson C, Caisander G (2005) Human embryonic stem cells and chromosome stability. APMIS 113:751–755",{"doi":1805},"10.1111\u002Fj.1600-0463.2005.apm_305.x",{"id":20,"text":1807,"url":20,"identifiers":1808},"Hoffman LM, Carpenter MK (2005) Characterization and culture of human embryonic stem cells. Nat Biotechnol 23:699–708",{"doi":1809},"10.1038\u002Fnbt1102",{"id":20,"text":1811,"url":20,"identifiers":1812},"Kaigler D, Mooney D (2001) Tissue engineering’s impact on dentistry. J Dent Educ 65:456–462",{"doi":1813},"10.1002\u002Fj.0022-0337.2001.65.5.tb03415.x",{"id":20,"text":1815,"url":20,"identifiers":1816},"Ludwig TE, Bergendahl V, Levenstein ME, Yu J, Probasco MD, Thomson JA (2006) Feeder-independent culture of human embryonic stem cells. Nat Methods 3:637–646 (Erratum in: Nat Methods. 3(2006):867)",{"doi":1817},"10.1038\u002Fnmeth902",{"id":20,"text":1819,"url":20,"identifiers":1820},"Maitra A, Arking DE, Shivapurkar N, Ikeda M, Stastny V, Kassauei K, Sui G, Cutler DJ, Liu Y, Brimble SN, Noaksson K, Hyllner J, Schulz TC, Zeng X, Freed WJ, Crook J, Abraham S, Colman A, Sartipy P, Matsui S, Carpenter M, Gazdar AF, Rao M, Chakravarti A (2005) Genomic alterations in cultured human embryonic stem cells. Nat Genet 37:1099–1103",{"doi":1821},"10.1038\u002Fng1631",{"id":20,"text":1823,"url":20,"identifiers":1824},"Mastromonaco GF, Perrault SD, Betts DH, King WA (2006) Role of chromosome stability and telomere length in the production of viable cell lines for somatic cell nuclear transfer. BMC Dev Biol 6:41",{"doi":1825},"10.1186\u002F1471-213X-6-41",{"id":20,"text":1827,"url":20,"identifiers":1828},"Mikkola M, Olsson C, Palgi J, Ustinov J, Palomaki T, Horelli-Kuitunen N, Knuutila S, Lundin K, Otonkoski T, Tuuri T (2006) Distinct differentiation characteristics of individual human embryonic stem cell lines. BMC Dev Biol 6:40",{"doi":1829},"10.1186\u002F1471-213X-6-40",{"id":20,"text":1831,"url":20,"identifiers":1832},"Mitalipova MM, Rao RR, Hoyer DM, Johnson JA, Meisner LF, Jones KL, Dalton S, Stice SL (2005) Preserving the genetic integrity of human embryonic stem cells. Nat Biotechnol 23:19–20",{"doi":1833},"10.1038\u002Fnbt0105-19",{"id":20,"text":1835,"url":20,"identifiers":1836},"Neff T, Beard BC, Kiem HP (2006) Survival of the fittest: in vivo selection and stem cell gene therapy. Blood 107:1751–1760",{"doi":1837},"10.1182\u002Fblood-2005-06-2335",{"id":20,"text":1839,"url":20,"identifiers":1840},"Rebuzzini P, Neri T, Mazzini G, Zuccotti M, Redi CA, Garagna S (2008) Karyotype analysis of the euploid cell population of a mouse embryonic stem cell line revealed a high incidence of chromosome abnormalities that varied during culture. Cytogenet Genome Res 121:18–24",{"doi":1841},"10.1159\u002F000124377",{"id":20,"text":1843,"url":20,"identifiers":1844},"Roschke AV, Stover K, Tonon G, Schäffer AA, Kirsch IR (2002) Stable karyotypes in epithelial cancer cell lines despite high rates of ongoing structural and numerical chromosomal instability. Neoplasia 4:19–31",{"doi":1845},"10.1038\u002Fsj.neo.7900197",{"id":20,"text":1847,"url":20,"identifiers":1848},"Strelchenko N, Verlinsky O, Kukharenko V, Verlinsky Y (2004) Morula-derived human embryonic stem cells. Reprod Biomed Online 9:623–629",{"doi":1849},"10.1016\u002FS1472-6483(10)61772-5",{"id":20,"text":1851,"url":20,"identifiers":1852},"Suchánek J, Soukup T, Ivancaková R, Karbanová J, Hubková V, Pytlík R, Kucerová L (2007) Human dental pulp stem cells–isolation and long term cultivation. Acta Medica (Hradec Kralove) 50:195–201",{"doi":1853},"10.14712\u002F18059694.2017.82",{"id":20,"text":1855,"url":20,"identifiers":1856},"Vorsanova SG, Yurov YB, Iororv IY (2010) Human interphase chromosomes: a review of available molecular cytogenetic technologies. Mol Cytogenet 11(3):1",{"doi":1857},"10.1186\u002F1755-8166-3-1",{"id":20,"text":1859,"url":20,"identifiers":1860},"Wang Y, Huso DL, Harrington J, Kellner J, Jeong DK, Turney J, McNiece IK (2005) Outgrowth of a transformed cell population derived from normal human BM mesenchymal stem cell culture. Cytotherapy 7:509–519",{"doi":1861},"10.1080\u002F14653240500363216",{"id":20,"text":1863,"url":20,"identifiers":1864},"Young CS, Terada S, Vacanti JP, Honda M, Bartlett JD, Yelick PC (2002) Tissue engineering of complex tooth structures on biodegradable polymer scaffolds. J Dent Res 81:695–700",{"doi":1865},"10.1177\u002F154405910208101008",{"id":20,"text":1867,"url":20,"identifiers":1868},"Young CS, Abukawa H, Asrican R, Ravens M, Troulis MJ, Kaban LB, Vacanti JP, Yelick PC (2005) Tissue-engineered hybrid tooth and bone. Tissue Eng 11:1599–1610",{"doi":1869},"10.1089\u002Ften.2005.11.1599",{"id":20,"text":1871,"url":20,"identifiers":1872},"Zhang ZX, Guan LX, Zhang K, Wang S, Cao PC, Wang YH, Wang Z, Dai LJ (2007) Cytogenetic analysis of human bone marrow-derived mesenchymal stem cells passaged in vitro. Cell Biol Int 31:645–648",{"doi":1873},"10.1016\u002Fj.cellbi.2006.11.025",{"id":1875,"createTime":1876,"updateTime":1877,"relativeEntities":1878,"slug":1879,"properties":1880,"entityType":203,"verifyStatus":204,"verifyTime":1891,"verifyNote":206,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":1892,"fullTextUrl":20,"authors":1893,"publicationType":276,"publisherRelationship":2054,"citationCount":21,"citationInfo":2114,"publishDate":2117,"publishYear":2115,"citationAnalyzeStatus":19,"lastCitationAnalyze":2118,"indexDatabases":2119,"openAccess":20,"references":20,"isForceReanalyzing":345},"1cf0360a-3529-46ee-8108-432971eb965c","2024-01-20T15:26:40.474+00:00","2026-05-22T15:39:10.139+00:00",[],"Cell-specific-detection-of-microRNA-expression-during-cardiomyogenesis-by-combined-in-situ-hybridization-and-immunohistochemistry",{"abstract":1881,"title":1883,"gsPaper":1885,"references":1887,"doi":1889},{"EN":1882},"MicroRNAs (miRNAs) regulate gene expression by mediating translational repression or mRNA degradation of their targets, and several miRNAs control developmental decisions through embryogenesis. In the developing heart, miRNA targets comprise key players mediating cardiac lineage determination. However, although several miRNAs have been identified as differentially regulated during cardiac development and disease, their distinct cell-specific localization remains largely undetermined, likely owing to a lack of adequate methods. We therefore report the development of a markedly improved approach combining fluorescence-based miRNA-in situ hybridization (miRNA-ISH) with immunohistochemistry (IHC). We have applied this protocol to differentiating embryoid bodies (EBs) as well as embryonic and adult mouse hearts, to detect miRNAs that were upregulated during EB cardiomyogenesis, as determined by array-based miRNA expression profiling. In this manner, we found specific co-localization of miR-1 to myosin positive cells (cardiomyocytes) of EBs, developing and mature hearts. In contrast, miR-125b and -199a did not localize to cardiomyocytes, as previously suggested for miR-199a, but were rather expressed in connective tissue cells of the heart. More specifically, by co-staining with α-smooth muscle actin (α-SMA) and collagen-I, we found that miR-125b and -199a localize to perivascular α-SMA− stromal cells. Our approach thus proved valid for determining cell-specific localization of miRNAs, and the findings we present highlight the importance of determining exact cell-specific localization of miRNAs by sequential miRNA-ISH and IHC in studies aiming at understanding the role of miRNAs and their targets. This approach will hopefully aid in identifying relevant miRNA targets of both the heart and other organs.",{"EN":1884},"Cell-specific detection of microRNA expression during cardiomyogenesis by combined in situ hybridization and immunohistochemistry",{"VOID":1886},"[\"10485236738702782675\"]",{"VOID":1888},"Andersen DC, Andersen P, Schneider M, Jensen HB, Sheikh SP (2009) Murine “cardiospheres” are not a source of stem cells with cardiomyogenic potential. Stem Cells 27(7):1571–1581. doi:10.1002\u002Fstem.72\nAplin M, Christensen GL, Schneider M, Heydorn A, Gammeltoft S, Kjolbye AL, Sheikh SP, Hansen JL (2007a) Differential extracellular signal-regulated kinases 1 and 2 activation by the angiotensin type 1 receptor supports distinct phenotypes of cardiac myocytes. Basic Clin Pharmacol Toxicol 100(5):296–301. doi:10.1111\u002Fj.1742-7843.2007.00064.x\nAplin M, Christensen GL, Schneider M, Heydorn A, Gammeltoft S, Kjolbye AL, Sheikh SP, Hansen JL (2007b) The angiotensin type 1 receptor activates extracellular signal-regulated kinases 1 and 2 by G protein-dependent and -independent pathways in cardiac myocytes and langendorff-perfused hearts. Basic Clin Pharmacol Toxicol 100(5):289–295. doi:10.1111\u002Fj.1742-7843.2007.00063.x\nBarroso-del Jesus A, Lucena-Aguilar G, Menendez P (2009) The miR-302–367 cluster as a potential stemness regulator in ESCs. Cell Cycle 8(3):394–398. doi:10.4161\u002Fcc.8.3.7554\nCheng Y, Ji R, Yue J, Yang J, Liu X, Chen H, Dean DB, Zhang C (2007) MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy? Am J Pathol 170(6):1831–1840. doi:10.2353\u002Fajpath.2007.061170\nCordes KR, Srivastava D (2009) MicroRNA regulation of cardiovascular development. Circ Res 104(6):724–732. doi:10.1161\u002FCIRCRESAHA.108.192872\nHaghikia A, Missol-Kolka E, Tsikas D, Venturini L, Brundiers S, Castoldi M, Muckenthaler MU, Eder M, Stapel B, Thum T, Petrasch-Parwez E, Drexler H, Hilfiker-Kleiner D, Scherr M (2010) Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes. Eur Heart J. doi:10.1093\u002Feurheartj\u002Fehq369\nHellemans J, Mortier G, De Paepe A, Speleman F, Vandesompele J (2007) qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data. Genome Biol 8(2):R19. doi:10.1186\u002Fgb-2007-8-2-r19\nIvey KN, Muth A, Arnold J, King FW, Yeh RF, Fish JE, Hsiao EC, Schwartz RJ, Conklin BR, Bernstein HS, Srivastava D (2008) MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell 2(3):219–229. doi:10.1016\u002Fj.stem.2008.01.016\nKeller G (2005) Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev 19(10):1129–1155. doi:10.1101\u002Fgad.1303605\nLatronico MV, Condorelli G (2009) MicroRNAs and cardiac pathology. Nat Rev Cardiol 6(6):419–429. doi:10.1038\u002Fnrcardio.2009.56\nLe MT, Teh C, Shyh-Chang N, Xie H, Zhou B, Korzh V, Lodish HF, Lim B (2009) MicroRNA-125b is a novel negative regulator of p53. Genes Dev 23(7):862–876. doi:10.1101\u002Fgad.1767609\nLiu N, Olson EN (2010) MicroRNA regulatory networks in cardiovascular development. Dev Cell 18(4):510–525. doi:10.1016\u002Fj.devcel.2010.03.010\nLiu N, Williams AH, Kim Y, McAnally J, Bezprozvannaya S, Sutherland LB, Richardson JA, Bassel-Duby R, Olson EN (2007) An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133. Proc Natl Acad Sci USA 104(52):20844–20849. doi:10.1073\u002Fpnas.0710558105\nNuovo GJ, Elton TS, Nana-Sinkam P, Volinia S, Croce CM, Schmittgen TD (2009) A methodology for the combined in situ analyses of the precursor and mature forms of microRNAs and correlation with their putative targets. Nat Protoc 4(1):107–115. doi:10.1038\u002Fnprot.2008.215\nObernosterer G, Martinez J, Alenius M (2007) Locked nucleic acid-based in situ detection of microRNAs in mouse tissue sections. Nat Protoc 2(6):1508–1514. doi:10.1038\u002Fnprot.2007.153\nRane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, Vatner DE, Vatner SF, Abdellatif M (2009) Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res 104(7):879–886. doi:10.1161\u002FCIRCRESAHA.108.193102\nSayed D, Hong C, Chen IY, Lypowy J, Abdellatif M (2007) MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res 100(3):416–424. doi:10.1161\u002F01.RES.0000257913.42552.23\nSempere LF, Preis M, Yezefski T, Ouyang H, Suriawinata AA, Silahtaroglu A, Conejo-Garcia JR, Kauppinen S, Wells W, Korc M (2010) Fluorescence-based codetection with protein markers reveals distinct cellular compartments for altered MicroRNA expression in solid tumors. Clin Cancer Res 16(16):4246–4255. doi:10.1158\u002F1078-0432.CCR-10-1152\nSilahtaroglu AN, Nolting D, Dyrskjot L, Berezikov E, Moller M, Tommerup N, Kauppinen S (2007) Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification. Nat Protoc 2(10):2520–2528. doi:10.1038\u002Fnprot.2007.313\nSong XW, Li Q, Lin L, Wang XC, Li DF, Wang GK, Ren AJ, Wang YR, Qin YW, Yuan WJ, Jing Q (2010) MicroRNAs are dynamically regulated in hypertrophic hearts, and miR-199a is essential for the maintenance of cell size in cardiomyocytes. J Cell Physiol 225(2):437–443. doi:10.1002\u002Fjcp.22217\nStary M, Schneider M, Sheikh SP, Weitzer G (2006) Parietal endoderm secreted S100A4 promotes early cardiomyogenesis in embryoid bodies. Biochem Biophys Res Commun 343(2):555–563. doi:10.1016\u002Fj.bbrc.2006.02.161\nTatsuguchi M, Seok HY, Callis TE, Thomson JM, Chen JF, Newman M, Rojas M, Hammond SM, Wang DZ (2007) Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J Mol Cell Cardiol 42(6):1137–1141. doi:10.1016\u002Fj.yjmcc.2007.04.004\nThum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW, Doevendans PA, Mummery CL, Borlak J, Haverich A, Gross C, Engelhardt S, Ertl G, Bauersachs J (2007) MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure. Circulation 116(3):258–267. doi:10.1161\u002FCIRCULATIONAHA.107.687947\nvan Rooij E (2011) The art of microRNA Research. Circ Res 108(2):219–234. doi:10.1161\u002FCIRCRESAHA.110.227496\nvan Rooij E, Sutherland LB, Liu N, Williams AH, McAnally J, Gerard RD, Richardson JA, Olson EN (2006) A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci USA 103(48):18255–18260. doi:10.1073\u002Fpnas.0608791103\nVandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3(7): RESEARCH0034. doi:10.1186\u002Fgb-2002-3-7-research0034\nVilleneuve LM, Kato M, Reddy MA, Wang M, Lanting L, Natarajan R (2010) Enhanced levels of microRNA-125b in vascular smooth muscle cells of diabetic db\u002Fdb mice lead to increased inflammatory gene expression by targeting the histone methyltransferase Suv39h1. Diabetes 59(11):2904–2915. doi:10.2337\u002Fdb10-0208\nYang B, Lin H, Xiao J, Lu Y, Luo X, Li B, Zhang Y, Xu C, Bai Y, Wang H, Chen G, Wang Z (2007) The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nat Med 13(4):486–491. doi:10.1038\u002Fnm1569\nZhao Y, Samal E, Srivastava D (2005) Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature 436(7048):214–220. doi:10.1038\u002Fnature03817\nZhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D (2007) Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1–2. 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of acute and especially chronic rejection after human cardiac transplantation is still challenging. Chronic rejection, represented by allograft vasculopathy (CAV) and cardiac interstitial fibrosis (CIF) is known to cause severe long-term complications. Rejection associated tissue-remodelling entails the reoccurrence of fetal variants of Fibronectin (Fn) and Tenascin-C (Tn-C), which are virtually absent in adult human organs. In a rat model, an extensive re-expression could be demonstrated for ED-A+ Fn with spatial association to CAV and CIF. Thus, it is of great interest to investigate the cardiac tissue expression and distribution in human samples. From 48 heart transplanted patients, 64 tissue specimens derived from right ventricular biopsies were available. Histopathological analysis was performed according to the International Society for Heart and Lung Transplantation (ISHLT) guidelines for the detection of acute rejection. By immunohistochemistry, protein expression of ED-A+ Fn, B+ Tn-C, alpha-smooth muscle actin, CD31 and CD45 was assessed and analysed semiquantitatively. Co-localisation studies were performed by means of immunofluorescence double labelling. Histopathological analysis of the 64 samples revealed different ISHLT grades (0R in 36 cases, 1R in 20 cases and 2R in 8 cases). There was a distinct and quantitatively relevant re-occurrence of ED-A+ Fn and B+ Tn-C in most samples. Semi-quantitative evaluation did not show any correlation to the acute rejection grade for all markers. Interestingly, significant correlations to the extent of inflammation could be shown for ED-A+ Fn (r = 0.442, p = 0.000) and B+ Tn-C (r = 0.408, p = 0.001) as well as between both proteins (r = 0.663, p = 0.000). A spatial association of ED-A+ Fn and B+ Tn-C to CAV and CIF could be demonstrated. A relevant re-occurrence of ED-A+ Fn and B+ Tn-C following human heart transplantation could be demonstrated with spatial association to signs of rejection and a significant correlation to tissue inflammation. These data might contribute to the identification of novel biomarkers reflecting the rejection process and to the development of promising strategies to image, prevent or treat cardiac rejection.",{"EN":2130},"De novo expression of fetal ED-A+ fibronectin and B+ tenascin-C splicing variants in human cardiac allografts: potential impact for targeted therapy of rejection",{"VOID":2132},"[\"5839473078379373551\"]",{"VOID":2134},"Armstrong AT, Binkley PF, Baker PB, Myerowitz PD, Leier CV (1998) Quantitative investigation of cardiomyocyte hypertrophy and myocardial fibrosis over 6 years after cardiac transplantation. J Am Coll Cardiol 32:704–710\nBaldinger A et al (2011) Comparative analysis of oncofetal fibronectin and tenascin-C expression in right atrial auricular and left ventricular human cardiac tissue from patients with coronary artery disease and aortic valve stenosis. Histochem Cell Biol 135:427–441. doi:10.1007\u002Fs00418-011-0809-z\nBerndt A, Borsi L, Hyckel P, Kosmehl H (2001) Fibrillary co-deposition of laminin-5 and large unspliced tenascin-C in the invasive front of oral squamous cell carcinoma in vivo and in vitro. J Cancer Res Clin Oncol 127:286–292\nBooth AJ et al (2012) Recipient-derived EDA fibronectin promotes cardiac allograft fibrosis. J Pathol 226:609–618. doi:10.1002\u002Fpath.3010\nBorsi L et al (1987) Monoclonal antibodies in the analysis of fibronectin isoforms generated by alternative splicing of mRNA precursors in normal and transformed human cells. J Cell Biol 104:595–600\nBorsi L, Balza E, Gaggero B, Allemanni G, Zardi L (1995) The alternative splicing pattern of the tenascin-C pre-mRNA is controlled by the extracellular pH. J Biol Chem 270:6243–6245\nCale R, Almeida M, Goncalves P, Rebocho MJ, Raposo L, Teles R, Mendes M (2012) Complications of endomyocardial biopsy after heart transplantation: a lesser evil. Rev Port Cardiol 31:159–162. doi:10.1016\u002Fj.repc.2011.12.006\nCasi G, Neri D (2012) Antibody-drug conjugates: basic concepts, examples and future perspectives. J Controll Release 161:422–428. doi:10.1016\u002Fj.jconrel.2012.01.026\nClausell N, Butany J, Molossi S, Lonn E, Gladstone P, Rabinovitch M, Daly PA (1995) Abnormalities in intramyocardial arteries detected in cardiac transplant biopsy specimens and lack of correlation with abnormal intracoronary ultrasound or endothelial dysfunction in large epicardial coronary arteries. J Am Coll Cardiol 26:110–119\nCoito AJ, Binder J, de Sousa M, Kupiec-Weglinski JW (1994) The expression of extracellular matrix proteins during accelerated rejection of cardiac allografts in sensitized rats. Transplantation 57:599–605\nCoito AJ, Brown LF, Peters JH, Kupiec-Weglinski JW, Van de Water L (1997) Expression of fibronectin splicing variants in organ transplantation: a differential pattern between rat cardiac allografts and isografts. Am J Pathol 150:1757–1772\nCoito AJ, de Sousa M, Kupiec-Weglinski JW (2000) Fibronectin in immune responses in organ transplant recipients. Dev Immunol 7:239–248\nCoito AJ, Kato H, Azimi R, Kupiec-Weglinski JW (2001) Chronic allograft rejection versus tolerance: a critical role for EIIIA(+) fibronectin. Transpl Proc 33:526–527\nCostanzo MR et al (2010) The international society of heart and lung transplantation guidelines for the care of heart transplant recipients. J Heart Lung Transplant 29:914–956. doi:10.1016\u002Fj.healun.2010.05.034\nCostello JP, Mohanakumar T, Nath DS (2013) Mechanisms of chronic cardiac allograft rejection. Tex Heart Inst J 40:395–399\nErba PA et al (2012) Radioimmunotherapy with radretumab in patients with relapsed hematologic malignancies. J Nucl Med 53:922–927. doi:10.2967\u002Fjnumed.111.101006\nFiechter M, Frey K, Fugmann T, Kaufmann PA, Neri D (2011) Comparative in vivo analysis of the atherosclerotic plaque targeting properties of eight human monoclonal antibodies. Atherosclerosis 214:325–330. doi:10.1016\u002Fj.atherosclerosis.2010.11.027\nFranz M et al (2007) A quantitative co-localization analysis of large unspliced tenascin-C(L) and laminin-5\u002Fgamma2-chain in basement membranes of oral squamous cell carcinoma by confocal laser scanning microscopy. J Oral Pathol Med 36:6–11. doi:10.1111\u002Fj.1600-0714.2006.00492.x\nFranz M et al (2009) Serum levels of large tenascin-C variants, matrix metalloproteinase-9, and tissue inhibitors of matrix metalloproteinases in concentric versus eccentric left ventricular hypertrophy. Eur J Heart Fail 11:1057–1062. doi:10.1093\u002Feurjhf\u002Fhfp128\nFranz M et al (2010a) Changes in extra cellular matrix remodelling and re-expression of fibronectin and tenascin-C splicing variants in human myocardial tissue of the right atrial auricle: implications for a targeted therapy of cardiovascular diseases using human SIP format antibodies. J Mol Histol 41:39–50. doi:10.1007\u002Fs10735-010-9260-z\nFranz M et al (2010b) Extra cellular matrix remodelling after heterotopic rat heart transplantation: gene expression profiling and involvement of ED-A+ fibronectin, alpha-smooth muscle actin and B+ tenascin-C in chronic cardiac allograft rejection. Histochem Cell Biol 134:503–517. doi:10.1007\u002Fs00418-010-0750-6\nFranz M et al (2011) Expression of extra domain a containing fibronectin in chronic cardiac allograft rejection. J Heart Lung Transplant 30:86–94. doi:10.1016\u002Fj.healun.2010.08.015\nFranz M, Neri D, Berndt A (2012) Chronic cardiac allograft rejection: critical role of ED-A(+) fibronectin and implications for targeted therapy strategies. J Pathol 226:557–561. doi:10.1002\u002Fpath.3968\nFranz M et al (2013) Selective imaging of chronic cardiac rejection using a human antibody specific to the alternatively spliced EDA domain of fibronectin. J Heart Lung Transplant 32:641–650. doi:10.1016\u002Fj.healun.2013.04.003\nGabler U et al (1996) Matrix remodelling in dilated cardiomyopathy entails the occurrence of oncofetal fibronectin molecular variants. Heart 75:358–362\nGlukhova MA, Frid MG, Shekhonin BV, Vasilevskaya TD, Grunwald J, Saginati M, Koteliansky VE (1989) Expression of extra domain a fibronectin sequence in vascular smooth muscle cells is phenotype dependent. J Cell Biol 109:357–366\nGutbrodt KL et al (2013) Antibody-based delivery of interleukin-2 to neovasculature has potent activity against acute myeloid leukemia. Sci Transl Med 5:201ra118. doi:10.1126\u002Fscitranslmed.3006221\nHamlin SK, Villars PS, Kanusky JT, Shaw AD (2004) Role of diastole in left ventricular function, II: diagnosis and treatment. Am J Crit Care, 13:453–466; quiz 467–458\nHemmerle T, Neri D (2013) The antibody-based targeted delivery of interleukin-4 and 12 to the tumor neovasculature eradicates tumors in three mouse models of cancer International journal of cancer Journal international du cancer doi:10.1002\u002Fijc.28359\nHeuveling DA et al (2013) Phase 0 microdosing PET study using the human mini antibody F16SIP in head and neck cancer patients. J Nucl Med 54:397–401. doi:10.2967\u002Fjnumed.112.111310\nHiemann NE, Wellnhofer E, Knosalla C, Lehmkuhl HB, Stein J, Hetzer R, Meyer R (2007) Prognostic impact of microvasculopathy on survival after heart transplantation: evidence from 9713 endomyocardial biopsies. Circulation 116:1274–1282. doi:10.1161\u002FCIRCULATIONAHA.106.647149\nImanaka-Yoshida K et al (2001) Tenascin-C modulates adhesion of cardiomyocytes to extracellular matrix during tissue remodeling after myocardial infarction. Lab Invest 81:1015–1024\nImanaka-Yoshida K et al (2002) Tenascin-C is a useful marker for disease activity in myocarditis. J Pathol 197:388–394. doi:10.1002\u002Fpath.1131\nJones FS, Jones PL (2000) The tenascin family of ECM glycoproteins: structure, function, and regulation during embryonic development and tissue remodeling. 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PV, Seregard S (2002) Age-related maculopathy: pathogenetic features and new treatment modalities. Acta Ophthalmol Scand 80:136–143",{"doi":562},{"id":558,"text":2642,"url":560,"identifiers":2643},"Algvere PV, Marshall J, Seregard S (2006) Age-related maculopathy and the impact of blue light hazard. Acta Ophthalmol Scand 84:4–15",{"doi":562},{"id":2645,"text":2646,"url":2647,"identifiers":2648},"888d4dfb-9241-496a-bd4f-d60ad2d5caab","Bagby S, Kim S, Maldonado E, Tong KI, Reinberg D, Ikura M (1995) Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein. Cell 82:857–867","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002F0092867495904832",{"doi":2649},"10.1016\u002F0092-8674(95)90483-2",{"id":558,"text":2651,"url":560,"identifiers":2652},"Bautista RD (1999) Glaucomatous neurodegeneration and the concept of neuroprotection. Int Ophthalmol Clin 39:57–70",{"doi":562},{"id":558,"text":2654,"url":560,"identifiers":2655},"Buratowski S, Zhou H (1993) Functional domains of transcription factor TFIIB. Proc Natl Acad Sci USA 90:5633–5637",{"doi":562},{"id":558,"text":2657,"url":560,"identifiers":2658},"Chiang YC, Komarnitsky P, Chase D, Denis CL (1996) ADR1 activation domains contact the histone acetyltransferase GCN5 and the core transcriptional factor TFIIB. J Biol Chem 271:32359–32365",{"doi":562},{"id":2660,"text":2661,"url":2662,"identifiers":2663},"05adf5cf-dae8-4762-bd54-21d0f05cb1cb","Chidlow G, Wood JP, Casson RJ (2007) Pharmacological neuroprotection for glaucoma. Drugs 67:725–759","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.2165\u002F00003495-200767050-00006",{"doi":2664},"10.2165\u002F00003495-200767050-00006",{"id":558,"text":2666,"url":560,"identifiers":2667},"Colgan J, Ashali H, Manley JL (1995) A direct interaction between a glutamine-rich activator and the N terminus of TFIIB can mediate transcriptional activation in vivo. Mol Cell Biol 15:2311–2320",{"doi":562},{"id":558,"text":2669,"url":560,"identifiers":2670},"Congdon N, O’Colmain B, Klaver CC, Klein R, Munoz B, Friedman DS, Kempen J, Taylor HR, Mitchell P (2004a) Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol 122:477–485",{"doi":562},{"id":558,"text":2672,"url":560,"identifiers":2673},"Congdon N, O’Colmain B, Klaver CC, Klein R, Munoz B, Friedman DS, Kempen J, Taylor HR, Mitchell P (2004b) Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol 122:477–485",{"doi":562},{"id":558,"text":2675,"url":560,"identifiers":2676},"Edelstein LC, Lagos L, Simmons M, Tirumalai H, Gelinas C (2003) NF-kappa B-dependent assembly of an enhanceosome-like complex on the promoter region of apoptosis inhibitor Bfl-1\u002FA1. Mol Cell Biol 23:2749–2761",{"doi":562},{"id":558,"text":2678,"url":560,"identifiers":2679},"Elsby LM, Roberts SG (2008) Interaction of the TFIIB zinc ribbon with RNA polymerase II. Biochem Soc Trans 36:595–598",{"doi":562},{"id":558,"text":2681,"url":560,"identifiers":2682},"Faitar SL, Brodie SA, Ponticelli AS (2001) Promoter-specific shifts in transcription initiation conferred by yeast TFIIB mutations are determined by the sequence in the immediate vicinity of the start sites. Mol Cell Biol 21:4427–4440",{"doi":562},{"id":558,"text":2684,"url":560,"identifiers":2685},"Friedman MJ, Shah AG, Fang ZH, Ward EG, Warren ST, Li S, Li XJ (2007) Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration. Nat Neurosci 10:1519–1528",{"doi":562},{"id":558,"text":2687,"url":560,"identifiers":2688},"Garcia-Ayuso D, Salinas-Navarro M, Agudo M, Cuenca N, Pinilla I, Vidal-Sanz M, Villegas-Perez MP (2010) Retinal ganglion cell numbers and delayed retinal ganglion cell death in the P23H rat retina. Exp Eye Res 91:800–810",{"doi":562},{"id":558,"text":2690,"url":560,"identifiers":2691},"Ghosh M, Elsby LM, Mal TK, Gooding JM, Roberts SG, Ikura M (2004) Probing Zn2 + -binding effects on the zinc-ribbon domain of human general transcription factor TFIIB. Biochem J 378:317–324",{"doi":562},{"id":558,"text":2693,"url":560,"identifiers":2694},"Gunnlaugsdottir E, Arnarsson A, Jonasson F (2008) Prevalence and causes of visual impairment and blindness in Icelanders aged 50 years and older: the Reykjavik eye study. Acta Ophthalmol 86:778–785",{"doi":562},{"id":558,"text":2696,"url":560,"identifiers":2697},"Hadzic E, Desai-Yajnik V, Helmer E, Guo S, Wu S, Koudinova N, Casanova J, Raaka BM, Samuels HH (1995) A 10-amino-acid sequence in the N-terminal A\u002FB domain of thyroid hormone receptor alpha is essential for transcriptional activation and interaction with the general transcription factor TFIIB. Mol Cell Biol 15:4507–4517",{"doi":562},{"id":558,"text":2699,"url":560,"identifiers":2700},"Jiang G, Zheng L, Pu J, Mei H, Zhao J, Huang K, Zeng F, Tong Q (2012) Small RNAs targeting transcription start site induce heparanase silencing through interference with transcription initiation in human cancer cells. PLoS ONE 7:e31379",{"doi":562},{"id":558,"text":2702,"url":560,"identifiers":2703},"Katai N, Yoshimura N (1999) Apoptotic retinal neuronal death by ischemia-reperfusion is executed by two distinct caspase family proteases. Invest Ophthalmol Vis Sci 40:2697–2705",{"doi":562},{"id":2705,"text":2706,"url":2707,"identifiers":2708},"a0fb5ae9-bc10-49fa-800f-dfc7ab00777b","Kermer P, Klocker N, Labes M, Thomsen S, Srinivasan A, Bahr M (1999) Activation of caspase-3 in axotomized rat retinal ganglion cells in vivo. FEBS Lett 453:361–364","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0014579399007474",{"doi":2709},"10.1016\u002Fs0014-5793(99)00747-4",{"id":558,"text":2711,"url":560,"identifiers":2712},"Lin YS, Ha I, Maldonado E, Reinberg D, Green MR (1991) Binding of general transcription factor TFIIB to an acidic activating region. Nature 353:569–571",{"doi":562},{"id":558,"text":2714,"url":560,"identifiers":2715},"Lipton SA (2007) Pathologically-activated therapeutics for neuroprotection: mechanism of NMDA receptor block by memantine and S-nitrosylation. Curr Drug Targets 8:621–632",{"doi":562},{"id":558,"text":2717,"url":560,"identifiers":2718},"Liu X, Berk AJ (1995) Reversal of in vitro p53 squelching by both TFIIB and TFIID. Mol Cell Biol 15:6474–6478",{"doi":562},{"id":2720,"text":2721,"url":2722,"identifiers":2723},"a8a411c3-85e1-436a-869c-7ca3dccadaf0","Liu Z, Wang D, Shao B, Wu X, Xu J, Lu Q, Wang Y, Li C, Shen A, Wu Q (2011) Increased expression of transcription initiation factor IIB after rat traumatic brain injury. J Mol Histol 42:265–271","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs10735-011-9330-x",{"doi":2724},"10.1007\u002Fs10735-011-9330-x",{"id":558,"text":2726,"url":560,"identifiers":2727},"Lizard G, Miguet C, Gueldry S, Monier S, Gambert P (1997) Flow cytometry measurement of DNA fragmentation in the course of cell death via apoptosis. New techniques for evaluation of DNA status for the pathologist. Ann Pathol 17:61–66",{"doi":562},{"id":558,"text":2729,"url":560,"identifiers":2730},"Marc RE, Jones BW, Watt CB, Vazquez-Chona F, Vaughan DK, Organisciak DT (2008) Extreme retinal remodeling triggered by light damage: implications for age related macular degeneration. Mol Vis 14:782–806",{"doi":562},{"id":558,"text":2732,"url":560,"identifiers":2733},"Marco-Gomariz MA, Hurtado-Montalban N, Vidal-Sanz M, Lund RD, Villegas-Perez MP (2006) Phototoxic-induced photoreceptor degeneration causes retinal ganglion cell degeneration in pigmented rats. J Comp Neurol 498:163–179",{"doi":562},{"id":558,"text":2735,"url":560,"identifiers":2736},"Nikolov DB, Chen H, Halay ED, Usheva AA, Hisatake K, Lee DK, Roeder RG, Burley SK (1995) Crystal structure of a TFIIB-TBP-TATA-element ternary complex. Nature 377:119–128",{"doi":562},{"id":558,"text":2738,"url":560,"identifiers":2739},"Pardee TS, Bangur CS, Ponticelli AS (1998) The N-terminal region of yeast TFIIB contains two adjacent functional domains involved in stable RNA polymerase II binding and transcription start site selection. J Biol Chem 273:17859–17864",{"doi":562},{"id":558,"text":2741,"url":560,"identifiers":2742},"Pinto I, Ware DE, Hampsey M (1992) The yeast SUA7 gene encodes a homolog of human transcription factor TFIIB and is required for normal start site selection in vivo. Cell 68:977–988",{"doi":562},{"id":558,"text":2744,"url":560,"identifiers":2745},"Roberts SG, Ha I, Maldonado E, Reinberg D, Green MR (1993) Interaction between an acidic activator and transcription factor TFIIB is required for transcriptional activation. Nature 363:741–744",{"doi":562},{"id":558,"text":2747,"url":560,"identifiers":2748},"Sauer F, Fondell JD, Ohkuma Y, Roeder RG, Jackle H (1995) Control of transcription by Kruppel through interactions with TFIIB and TFIIE beta. Nature 375:162–164",{"doi":562},{"id":558,"text":2750,"url":560,"identifiers":2751},"Shaw SP, Carson DJ, Dorsey MJ, Ma J (1997) Mutational studies of yeast transcription factor IIB in vivo reveal a functional surface important for gene activation. Proc Natl Acad Sci USA 94:2427–2432",{"doi":562},{"id":558,"text":2753,"url":560,"identifiers":2754},"Springer JE, Nottingham SA, McEwen ML, Azbill RD, Jin Y (2001) Caspase-3 apoptotic signaling following injury to the central nervous system. Clin Chem Lab Med 39:299–307",{"doi":562},{"id":558,"text":2756,"url":560,"identifiers":2757},"Sun MH, Pang JH, Chen SL, Kuo PC, Chen KJ, Kao LY, Wu JY, Lin KK, Tsao YP (2007) Photoreceptor protection against light damage by AAV-mediated overexpression of heme oxygenase-1. Invest Ophthalmol Vis Sci 48:5699–5707",{"doi":562},{"id":558,"text":2759,"url":560,"identifiers":2760},"Villegas-Perez MP, Lawrence JM, Vidal-Sanz M, Lavail MM, Lund RD (1998) Ganglion cell loss in RCS rat retina: a result of compression of axons by contracting intraretinal vessels linked to the pigment epithelium. J Comp Neurol 392:58–77",{"doi":562},{"id":558,"text":2762,"url":560,"identifiers":2763},"Wang S, Villegas-Perez MP, Holmes T, Lawrence JM, Vidal-Sanz M, Hurtado-Montalban N, Lund RD (2003) Evolving neurovascular relationships in the RCS rat with age. Curr Eye Res 27:183–196",{"doi":562},{"id":558,"text":2765,"url":560,"identifiers":2766},"Wu WH, Hampsey M (1999) An activation-specific role for transcription factor TFIIB in vivo. Proc Natl Acad Sci USA 96:2764–2769",{"doi":562},{"id":558,"text":2768,"url":560,"identifiers":2769},"Zhang R, Averboukh L, Zhu W, Zhang H, Jo H, Dempsey PJ, Coffey RJ, Pardee AB, Liang P (1998) Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation. Mol Cell Biol 18:6131–6141",{"doi":562}]