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Pharmacology, 76, 68, 10.1124\u002Fmol.108.054262",{"doi":401},"10.1124\u002Fmol.108.054262",{"id":24,"text":403,"url":24,"identifiers":404},"Lupp, 2011, Neuroendocrinology, 94, 255, 10.1159\u002F000329876",{"doi":405},"10.1159\u002F000329876",{"id":24,"text":407,"url":24,"identifiers":408},"2011, Molecular Endocrinology, 25, 859, 10.1210\u002Fme.2010-0407",{"doi":409},"10.1210\u002Fme.2010-0407",{"id":24,"text":411,"url":24,"identifiers":412},"2008, Molecular Endocrinology, 22, 676, 10.1210\u002Fme.2007-0068",{"doi":413},"10.1210\u002Fme.2007-0068",{"id":24,"text":415,"url":24,"identifiers":416},"2010, Molecular Endocrinology, 24, 436, 10.1210\u002Fme.2009-0315",{"doi":417},"10.1210\u002Fme.2009-0315",{"id":24,"text":419,"url":24,"identifiers":420},"Reubi, 2003, Endocrine Reviews, 24, 389, 10.1210\u002Fer.2002-0007",{"doi":421},"10.1210\u002Fer.2002-0007",{"id":24,"text":423,"url":24,"identifiers":424},"Reubi, 1987, Cancer Research, 47, 551",{},{"id":24,"text":426,"url":24,"identifiers":427},"Reubi, 1990, The Journal of steroid biochemistry and molecular biology, 37, 1073, 10.1016\u002F0960-0760(90)90468-Z",{"doi":428},"10.1016\u002F0960-0760(90)90468-Z",{"id":24,"text":430,"url":24,"identifiers":431},"1991, Acta oncol  gica, 30, 463",{},{"id":24,"text":433,"url":24,"identifiers":434},"Reubi, 1992, The Journal of steroid biochemistry and molecular biology, 43, 27, 10.1016\u002F0960-0760(92)90184-K",{"doi":435},"10.1016\u002F0960-0760(92)90184-K",{"id":24,"text":437,"url":24,"identifiers":438},"Reubi, 1996, Metabolism: clinical and experimental, 45, 39, 10.1016\u002FS0026-0495(96)90077-3",{"doi":439},"10.1016\u002FS0026-0495(96)90077-3",{"id":24,"text":441,"url":24,"identifiers":442},"Reubi, 1998, American Journal Of Pathology, 153, 233, 10.1016\u002FS0002-9440(10)65564-2",{"doi":443},"10.1016\u002FS0002-9440(10)65564-2",{"id":24,"text":445,"url":24,"identifiers":446},"Reubi, 2000, Journal of Clinical Endocrinology & Metabolism, 85, 3882, 10.1210\u002Fjc.85.10.3882",{"doi":447},"10.1210\u002Fjc.85.10.3882",{"id":24,"text":449,"url":24,"identifiers":450},"2010, Journal of Clinical Endocrinology & Metabolism, 95, 2343, 10.1210\u002Fjc.2009-2487",{"doi":451},"10.1210\u002Fjc.2009-2487",{"id":24,"text":453,"url":24,"identifiers":454},"Roth, 1997, Journal of Biological Chemistry, 272, 23769, 10.1074\u002Fjbc.272.38.23769",{"doi":455},"10.1074\u002Fjbc.272.38.23769",{"id":24,"text":457,"url":24,"identifiers":458},"Roth, 1997, DNA and cell biology, 16, 111, 10.1089\u002Fdna.1997.16.111",{"doi":459},"10.1089\u002Fdna.1997.16.111",{"id":24,"text":461,"url":24,"identifiers":462},"2004, Journal of Biological Chemistry, 279, 8029, 10.1074\u002Fjbc.M310792200",{"doi":463},"10.1074\u002Fjbc.M310792200",{"id":24,"text":465,"url":24,"identifiers":466},"Schreff, 2000, Journal of Neuroscience, 20, 3785, 10.1523\u002FJNEUROSCI.20-10-03785.2000",{"doi":467},"10.1523\u002FJNEUROSCI.20-10-03785.2000",{"id":24,"text":469,"url":24,"identifiers":470},"Schulz, 2000, Journal of physiology, Paris, 94, 259, 10.1016\u002FS0928-4257(00)00212-6",{"doi":471},"10.1016\u002FS0928-4257(00)00212-6",{"id":24,"text":473,"url":24,"identifiers":474},"Schulz, 2000, Clinical Cancer Research, 6, 1865",{},{"id":24,"text":476,"url":24,"identifiers":477},"Schwarzler, 2000, Journal of Biological Chemistry, 275, 9557, 10.1074\u002Fjbc.275.13.9557",{"doi":478},"10.1074\u002Fjbc.275.13.9557",{"id":24,"text":480,"url":24,"identifiers":481},"Sheng, 2001, Annual review of neuroscience, 24, 1, 10.1146\u002Fannurev.neuro.24.1.1",{"doi":482},"10.1146\u002Fannurev.neuro.24.1.1",{"id":24,"text":484,"url":24,"identifiers":485},"Stroh, 2000, Endocrinology, 141, 354, 10.1210\u002Fen.141.1.354",{"doi":486},"10.1210\u002Fen.141.1.354",{"id":24,"text":488,"url":24,"identifiers":489},"Stroh, 2009, Journal of Neuroscience, 29, 8198, 10.1523\u002FJNEUROSCI.0336-09.2009",{"doi":490},"10.1523\u002FJNEUROSCI.0336-09.2009",{"id":24,"text":492,"url":24,"identifiers":493},"Stumm, 2004, Journal of Neuroscience, 24, 11404, 10.1523\u002FJNEUROSCI.3834-04.2004",{"doi":494},"10.1523\u002FJNEUROSCI.3834-04.2004",{"id":24,"text":496,"url":24,"identifiers":497},"Tulipano, 2007, European Journal of Endocrinology, 156, S3, 10.1530\u002Feje.1.02354",{"doi":498},"10.1530\u002Feje.1.02354",{"id":24,"text":500,"url":24,"identifiers":501},"2004, Journal of Biological Chemistry, 279, 21374, 10.1074\u002Fjbc.M313522200",{"doi":502},"10.1074\u002Fjbc.M313522200",{"id":24,"text":504,"url":24,"identifiers":505},"Weckbecker, 2003, Nature reviews. Drug discovery, 2, 999, 10.1038\u002Fnrd1255",{"doi":506},"10.1038\u002Fnrd1255",{"id":24,"text":508,"url":24,"identifiers":509},"2005, Journal of Biological Chemistry, 280, 32419, 10.1074\u002Fjbc.M507198200",{"doi":510},"10.1074\u002Fjbc.M507198200",{"id":24,"text":512,"url":24,"identifiers":513},"Zitzer, 1999, Journal of Biological Chemistry, 274, 32997, 10.1074\u002Fjbc.274.46.32997",{"doi":514},"10.1074\u002Fjbc.274.46.32997",{"id":24,"text":516,"url":24,"identifiers":517},"Zitzer, 1999, Journal of Biological Chemistry, 274, 18153, 10.1074\u002Fjbc.274.26.18153",{"doi":518},"10.1074\u002Fjbc.274.26.18153",false,{"id":521,"createTime":522,"updateTime":523,"relativeEntities":524,"slug":525,"properties":526,"entityType":109,"verifyStatus":23,"verifyTime":543,"verifyNote":544,"languages":545,"translateLanguages":546,"viewCount":25,"primaryUrl":548,"fullTextUrl":24,"authors":549,"publicationType":203,"publisherRelationship":605,"citationCount":650,"citationInfo":651,"publishDate":656,"publishYear":652,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":657,"openAccess":24,"references":658,"isForceReanalyzing":519},"8b91100d-2c8b-4ea3-99af-67f3d1892b6b","2024-10-15T13:46:26.338+00:00","2025-02-08T05:03:42.177+00:00",[],"Developmental-and-tissue-regulated-expression-of-IGF-I-and-IGF-II-mRNAs-in-Sparus-aurata",{"mag":527,"keywords":529,"openalex":531,"abstract":533,"title":536,"pm":539,"doi":541},{"VOID":528},"1979687455",{"VI":530},"",{"VOID":532},"W1979687455",{"EN":534,"VI":535},"\u003Cjats:title>ABSTRACT\u003C\u002Fjats:title>\n\u003Cjats:p>Recent studies have shown that homologues of the mammalian IGF-I and -II genes are also found in teleosts. We report here the cDNAs coding for IGF-I and IGF-II cloned from the gilthead seabream, \u003Cjats:italic>Sparus aurata\u003C\u002Fjats:italic>. Sequence comparisons revealed that both IGFs have been well conserved among teleosts, although \u003Cjats:italic>Sparus\u003C\u002Fjats:italic> IGF-I is shorter by three amino acid residues due to truncated B-and C-domains. Using the cloned cDNAs as probes, the relative expression of IGF-I and IGF-II mRNAs were assayed in different \u003Cjats:italic>Sparus\u003C\u002Fjats:italic> tissues. \u003Cjats:italic>Sparus\u003C\u002Fjats:italic> liver clearly contained the highest level of IGF-I mRNA while relatively high levels of IGF-II mRNA were found in liver, heart and gill using the ribonuclease protection assay. After GH administration the amount of IGF-I mRNA was increased by 220% in liver but no changes in IGF-II mRNA levels were detected in any tissue. We also assayed the expression of IGF-I and IGF-II in \u003Cjats:italic>Sparus\u003C\u002Fjats:italic> during early development. The IGF-II mRNA level was highest in larva 1 day after hatching and decreased thereafter. In contrast, IGF-I mRNA was detected in 1-day-old larva but there was an increase in expression in 12- and 16-day-old larva. These results demonstrated that the expression of IGF-I and IGF-II is highly regulated in teleosts and suggest that they play distinct roles during growth and development.\u003C\u002Fjats:p>","\u003Cjats:title>TÓM TẮT\u003C\u002Fjats:title>\n\u003Cjats:p>Các nghiên cứu gần đây đã chỉ ra rằng các đồng hình của gen IGF-I và IGF-II ở động vật có vú cũng được tìm thấy ở cá xương. Chúng tôi báo cáo ở đây các cDNA mã hóa cho IGF-I và IGF-II được phân lập từ cá chẽm, \u003Cjats:italic>Sparus aurata\u003C\u002Fjats:italic>. So sánh chuỗi nucleotide cho thấy cả hai IGF đều được bảo tồn tốt giữa các loài cá xương, mặc dù IGF-I của \u003Cjats:italic>Sparus\u003C\u002Fjats:italic> ngắn hơn ba acid amin do bị rút ngắn các miền B và C. Sử dụng các cDNA đã phân lập làm mồi, mức biểu hiện tương đối của mRNA IGF-I và IGF-II đã được phân tích trong các mô khác nhau của \u003Cjats:italic>Sparus\u003C\u002Fjats:italic>. Gan của \u003Cjats:italic>Sparus\u003C\u002Fjats:italic> rõ ràng chứa mức độ mRNA IGF-I cao nhất trong khi mức độ mRNA IGF-II cũng tương đối cao được tìm thấy ở gan, tim và mang thông qua xét nghiệm bảo vệ ribonuclease. Sau khi tiêm GH, lượng mRNA IGF-I đã tăng 220% trong gan nhưng không phát hiện sự thay đổi nào ở mức độ mRNA IGF-II trong bất kỳ mô nào. Chúng tôi cũng đã phân tích biểu hiện của IGF-I và IGF-II trong \u003Cjats:italic>Sparus\u003C\u002Fjats:italic> trong giai đoạn phát triển sớm. Mức độ mRNA IGF-II cao nhất ở ấu trùng 1 ngày sau nở và giảm dần. Ngược lại, mRNA IGF-I được phát hiện ở ấu trùng 1 ngày tuổi nhưng có sự gia tăng trong biểu hiện ở ấu trùng 12 và 16 ngày tuổi. Những kết quả này cho thấy rằng biểu hiện của IGF-I và IGF-II được điều chỉnh chặt chẽ ở cá xương và gợi ý rằng chúng đóng vai trò khác nhau trong quá trình tăng trưởng và phát triển.\u003C\u002Fjats:p>",{"EN":537,"VI":538},"Developmental and tissue-regulated expression of IGF-I and IGF-II mRNAs in Sparus aurata","Biểu hiện mRNA của IGF-I và IGF-II trong giai đoạn phát triển và theo mô của \u003Cem>Sparus aurata\u003C\u002Fem>",{"VOID":540},"9156515",{"VOID":542},"10.1677\u002Fjme.0.0160123","2024-10-15T13:46:26.337+00:00","Author affiliation is blank",[113],[547],"VI","https:\u002F\u002Fjme.bioscientifica.com\u002Fview\u002Fjournals\u002Fjme\u002F16\u002F2\u002Fjme_16_2_003.xml",[550,567,576,585,595],{"id":551,"sortIndex":25,"researcher":24,"roles":552,"affiliations":553,"properties":562,"displayName":564,"givenName":24,"familyName":24},"1a6bae7d-8182-4c2c-a542-8a1af8fe7d4c",[],[554],{"id":555,"sortIndex":25,"affiliation":556,"properties":24},"29423b7d-4e86-4920-8ae3-8369da89d088",{"id":555,"createTime":24,"updateTime":24,"relativeEntities":557,"slug":24,"properties":558,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":561,"statistic":24},[],{"title":559},{"EN":560},"Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637, USA.",[],{"title":563,"openalex":565},{"EN":564},"Stephen J. Duguay",{"VOID":566},"A5050710903",{"id":568,"sortIndex":130,"researcher":24,"roles":569,"affiliations":570,"properties":571,"displayName":573,"givenName":24,"familyName":24},"73f89453-b35e-4276-9089-6fa0b73343c4",[],[],{"title":572,"openalex":574},{"EN":573},"Jie Lai‐Zhang",{"VOID":575},"A5059678086",{"id":577,"sortIndex":163,"researcher":24,"roles":578,"affiliations":579,"properties":580,"displayName":582,"givenName":24,"familyName":24},"78111fbf-6363-45d2-9a27-8cb3fb080627",[],[],{"title":581,"openalex":583},{"EN":582},"D F Steiner",{"VOID":584},"A5022917521",{"id":586,"sortIndex":587,"researcher":24,"roles":588,"affiliations":589,"properties":590,"displayName":592,"givenName":24,"familyName":24},"88f30ef0-6b61-4fe5-93b5-0e219c155186",3,[],[],{"title":591,"openalex":593},{"EN":592},"Bruria Funkenstein",{"VOID":594},"A5058645804",{"id":596,"sortIndex":597,"researcher":24,"roles":598,"affiliations":599,"properties":600,"displayName":602,"givenName":24,"familyName":24},"a82c4cc8-8889-4604-9111-67bc5a1af5b7",4,[],[],{"title":601,"openalex":603},{"EN":602},"Shu Jin Chan",{"VOID":604},"A5080725730",{"url":24,"publisher":606,"properties":643},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":607,"slug":10,"properties":608,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":613,"manageAffiliations":622,"indexDatabases":628,"url":83,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":609,"eissn":610,"issn":611,"title":612},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[614,618],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":615,"label":616,"description":617,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":619,"label":620,"description":621,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[623],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":624,"slug":24,"properties":625,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":627,"statistic":24},[],{"title":626},{"EN":45},[],[629,636],{"id":49,"indexDatabase":630,"url":60,"indexYears":61,"academicFieldIds":635,"indexDatabaseRanking":65},{"id":51,"createTime":24,"updateTime":24,"relativeEntities":631,"label":632,"description":633,"key":57,"publicationTags":634,"standard":24},[],{"EN":54,"VI":54},{"EN":54,"VI":56},[59],[63,64],{"id":67,"indexDatabase":637,"url":80,"indexYears":24,"academicFieldIds":642,"indexDatabaseRanking":24},{"id":69,"createTime":24,"updateTime":24,"relativeEntities":638,"label":639,"description":640,"key":76,"publicationTags":641,"standard":24},[],{"EN":72,"VI":72},{"EN":74,"VI":75},[78,79],[82],{"issue":644,"pages":646,"volume":648},{"VOID":645},"2",{"VOID":647},"123-132",{"VOID":649},"16",159,{"total":650,"publishYear":652,"statisticByYear":653},1996,{"2012":597,"2013":654,"2014":597,"2015":587,"2016":655,"2017":130,"2018":130,"2019":597,"2020":130,"2021":130,"2022":163,"2023":597,"2024":130},5,6,"1996-04-01",[78,65],[],{"id":660,"createTime":661,"updateTime":662,"relativeEntities":663,"slug":664,"properties":665,"entityType":109,"verifyStatus":23,"verifyTime":661,"verifyNote":544,"languages":681,"translateLanguages":682,"viewCount":25,"primaryUrl":683,"fullTextUrl":24,"authors":684,"publicationType":203,"publisherRelationship":751,"citationCount":795,"citationInfo":796,"publishDate":799,"publishYear":797,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":800,"openAccess":24,"references":801,"isForceReanalyzing":519},"e7599ab5-9a72-41f8-8cd6-8bcf33e4ce8b","2024-09-11T18:50:18.536+00:00","2025-02-08T05:02:45.794+00:00",[],"Cloning-and-sequence-analysis-of-the-cDNA-encoding-P-450-aromatase-P450arom-from-a-rainbow-trout-Oncorhynchus-mykiss-ovary-relationship-between-the-amount-of-P450arom-mRNA-and-the-production-of-oestradiol-17%CE%B2-in-the-ovary",{"mag":666,"keywords":668,"openalex":669,"abstract":671,"title":674,"pm":677,"doi":679},{"VOID":667},"2164788243",{"VI":530},{"VOID":670},"W2164788243",{"EN":672,"VI":673},"\u003Cjats:title>ABSTRACT\u003C\u002Fjats:title>\n\u003Cjats:p>The enzyme aromatase P-450 (P450arom) catalyses the conversion of androgen to oestrogen. A cDNA insert encoding P450arom was isolated from a rainbow trout (\u003Cjats:italic>Oncorhynchus mykiss\u003C\u002Fjats:italic>) ovary cDNA library. The insert was sequenced and found to contain an open-reading frame predicted to encode a protein of 522 amino acid residues. The deduced polypeptide is 52% homologous with human, mouse and rat P450arom and 53% homologous with that of chicken. The insert was confirmed to encode P450arom by introducing it into COS-1 monkey kidney tumour cells (COS-1 cells) and detecting the conversion of testosterone to oestradiol-17β by radioimmunoassay. The N-terminal region of the deduced polypeptide was 19 amino acids longer than that of the other four species, and was found by hydropathy plotting to be very hydrophobic.\u003C\u002Fjats:p>\n\u003Cjats:p>Northern blot analysis revealed 2.6kb RNA transcripts which were present in the trout ovary during vitellogenesis and hybridized to the cDNA insert. In preparations from subsequent stages of ovarian development, no RNA transcripts hybridized to the probe. Since the RNA transcripts are present only during the stage of oestradiol-β production by the ovarian follicles, oestradiol-17β production may be regulated, in part, by the amount of P450arom mRNA present.\u003C\u002Fjats:p>","\u003Cjats:title>TÓM TẮT\u003C\u002Fjats:title>\n\u003Cjats:p>Enzym aromatase P-450 (P450arom) xúc tác quá trình chuyển đổi androgen thành estrogen. Một đoạn cDNA mã hóa P450arom đã được tách từ thư viện cDNA của buồng trứng cá hồi cầu vồng (\u003Cjats:italic>Oncorhynchus mykiss\u003C\u002Fjats:italic>). Đoạn này đã được giải trình tự và phát hiện có một khung đọc mở dự đoán mã hóa cho một protein có 522 dư lượng amino acid. Polypeptide suy diễn có độ tương đồng 52% với P450arom của người, chuột và chuột lang, và 53% với của gà. Đoạn đã được xác nhận mã hóa P450arom bằng cách đưa nó vào các tế bào khối u thận khỉ COS-1 (tế bào COS-1) và phát hiện sự chuyển đổi testosterone thành oestradiol-17β bằng phương pháp đo miễn dịch phóng xạ. Vùng đầu N của polypeptide suy diễn dài hơn 19 amino acid so với các loài còn lại và được phát hiện bằng đồ thị độ ưa nước là rất kị nước.\u003C\u002Fjats:p>\n\u003Cjats:p>Phân tích Northern blot cho thấy có các bản sao RNA dài 2.6kb có mặt trong buồng trứng cá hồi trong quá trình vitellogenesis và đã kết hợp với đoạn cDNA. Trong các mẫu từ các giai đoạn phát triển buồng trứng tiếp theo, không có bản sao RNA nào kết hợp với đầu dò. Vì các bản sao RNA chỉ có mặt trong giai đoạn sản xuất oestradiol-β bởi các nang trứng, sản xuất oestradiol-17β có thể được điều chỉnh, một phần, bởi lượng mRNA P450arom có mặt.\u003C\u002Fjats:p>",{"EN":675,"VI":676},"Cloning and sequence analysis of the cDNA encoding P-450 aromatase (P450arom) from a rainbow trout (Oncorhynchus mykiss) ovary; relationship between the amount of P450arom mRNA and the production of oestradiol-17β in the ovary","Khảo sát và phân tích trình tự cDNA mã hóa P-450 aromatase (P450arom) từ buồng trứng cá hồi cầu vồng (Oncorhynchus mykiss); mối quan hệ giữa lượng mRNA P450arom và sản xuất oestradiol-17β trong buồng 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Các bằng chứng ngày càng tăng trong tài liệu đã chỉ ra rằng các đường dẫn tín hiệu PI3K\u002FPTEN\u002FAkt và TSC\u002FmTOR là những yếu tố điều chỉnh quan trọng chức năng buồng trứng, bao gồm sự ngủ đông, kích hoạt và tồn tại của các nang nguyên thủy, sự tăng sinh và biệt hóa của tế bào nang, cũng như sự trưởng thành giảm nhiễm của trứng. Sự rối loạn trong các đường dẫn tín hiệu này có thể góp phần vào tình trạng vô sinh do sự phát triển nang bị suy yếu, sự phát triển trứng trong nang, và sự rụng trứng. Bài báo này tổng quan về trạng thái hiện tại của kiến thức về vai trò chức năng của các đường dẫn PI3K\u002FPTEN\u002FAkt và TSC\u002FmTOR trong quá trình sinh tinh và hình thành nang ở động vật có vú và mối quan hệ của chúng với vô sinh nữ.\u003C\u002Fjats:p>",{"EN":818,"VI":819},"PI3K\u002FPTEN\u002FAkt and TSC\u002FmTOR signaling pathways, ovarian dysfunction, and infertility: an update","Đường dẫn tín hiệu PI3K\u002FPTEN\u002FAkt và TSC\u002FmTOR, rối loạn chức năng buồng trứng và vô sinh: một cập 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10.1186\u002F1757-2215-2-17",{"doi":1035},"10.1186\u002F1757-2215-2-17",{"id":24,"text":1037,"url":24,"identifiers":1038},"2008, Molecular Endocrinology, 22, 2128, 10.1210\u002Fme.2008-0095",{"doi":1039},"10.1210\u002Fme.2008-0095",{"id":24,"text":1041,"url":24,"identifiers":1042},"Farini, 2007, Developmental biology, 306, 572, 10.1016\u002Fj.ydbio.2007.03.031",{"doi":1043},"10.1016\u002Fj.ydbio.2007.03.031",{"id":24,"text":1045,"url":24,"identifiers":1046},"Fassnacht, 2006, Current medicinal chemistry, 13, 1397, 10.2174\u002F092986706776872943",{"doi":1047},"10.2174\u002F092986706776872943",{"id":24,"text":1049,"url":24,"identifiers":1050},"Flanagan, 1991, Cell, 64, 1025, 10.1016\u002F0092-8674(91)90326-T",{"doi":1051},"10.1016\u002F0092-8674(91)90326-T",{"id":24,"text":1053,"url":24,"identifiers":1054},"2014, Biology of Reproduction, 90, 86, 10.1095\u002Fbiolreprod.113.115089",{"doi":1055},"10.1095\u002Fbiolreprod.113.115089",{"id":24,"text":1057,"url":24,"identifiers":1058},"2011, Reproduction, 141, 759, 10.1530\u002FREP-10-0489",{"doi":1059},"10.1530\u002FREP-10-0489",{"id":24,"text":1061,"url":24,"identifiers":1062},"Goto, 2007, Journal of assisted reproduction and genetics, 24, 541, 10.1007\u002Fs10815-007-9156-3",{"doi":1063},"10.1007\u002Fs10815-007-9156-3",{"id":24,"text":1065,"url":24,"identifiers":1066},"2009, Reproduction, 137, 835, 10.1530\u002FREP-08-0315",{"doi":1067},"10.1530\u002FREP-08-0315",{"id":24,"text":1069,"url":24,"identifiers":1070},"Greenfeld, 2007, Reproduction, 133, 865, 10.1530\u002FREP-06-0270",{"doi":1071},"10.1530\u002FREP-06-0270",{"id":24,"text":1073,"url":24,"identifiers":1074},"Greenseid, 2011, Reproductive Sciences, 18, 892, 10.1177\u002F1933719111398502",{"doi":1075},"10.1177\u002F1933719111398502",{"id":24,"text":1077,"url":24,"identifiers":1078},"Gu, 2011, 6, e25984, 10.1371\u002Fjournal.pone.0025984",{"doi":1079},"10.1371\u002Fjournal.pone.0025984",{"id":24,"text":1081,"url":24,"identifiers":1082},"Han, 2006, The EMBO 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10.1093\u002Fhmg\u002Fddt486",{"doi":1384},"10.1093\u002Fhmg\u002Fddt486",{"id":1386,"createTime":1387,"updateTime":1388,"relativeEntities":1389,"slug":1390,"properties":1391,"entityType":109,"verifyStatus":110,"verifyTime":1407,"verifyNote":111,"languages":1408,"translateLanguages":1409,"viewCount":25,"primaryUrl":1410,"fullTextUrl":24,"authors":1411,"publicationType":203,"publisherRelationship":1467,"citationCount":1511,"citationInfo":1512,"publishDate":1515,"publishYear":1513,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":1516,"openAccess":24,"references":1517,"isForceReanalyzing":519},"f8491108-fee0-4a2a-9cfc-d177311902bd","2024-09-11T19:23:09.526+00:00","2025-02-08T05:00:54.424+00:00",[],"Subtilase-like-pro-protein-convertases-from-molecular-specificity-to-therapeutic-applications",{"mag":1392,"keywords":1394,"openalex":1395,"abstract":1397,"title":1400,"pm":1403,"doi":1405},{"VOID":1393},"2121093397",{"VI":530},{"VOID":1396},"W2121093397",{"EN":1398,"VI":1399},"\u003Cjats:p>Limited proteolysis of most large protein precursors is carried out in vivo by the subtilisin-like pro-protein convertases. Many important biological processes such as peptide hormone synthesis, viral protein processing and receptor maturation involve proteolytic processing by these enzymes, making them potential targets for the development of novel therapeutic agents. However, the efficient development of such molecules requires a better understanding of the molecular mechanisms of proteolytic protein processing. Herein, we review the most recent findings on the molecular aspects of subtilisin-like convertase activity, such as the structural analysis of the proteases, the mechanisms of enzyme\u002Fsubstrate specificity, their interaction with other proteins such as 7B2, and the comparative tissue and cellular distribution of the enzymes and their substrates. These data are then used as a background for the review of the known biological functions of subtilisin-like pro-protein convertases, the reported clinical cases involving proteolytic processing defects and, finally, the ongoing development of new therapeutic inhibitor molecules based on this knowledge.\u003C\u002Fjats:p>","\u003Cjats:p>Proteolysis giới hạn của hầu hết các tiền chất protein lớn được thực hiện trong cơ thể bởi các chuyển thể pro-protein giống subtilisin. Nhiều quá trình sinh học quan trọng như tổng hợp hormone peptide, xử lý protein virus và trưởng thành của thụ thể liên quan đến sự xử lý proteolytic bởi các enzyme này, làm cho chúng trở thành các mục tiêu tiềm năng cho sự phát triển của các chất điều trị mới. Tuy nhiên, sự phát triển hiệu quả của các phân tử như vậy đòi hỏi một hiểu biết sâu sắc hơn về các cơ chế phân tử của quá trình xử lý protein proteolytic. Trong bài viết này, chúng tôi xem xét những phát hiện gần đây nhất về các khía cạnh phân tử của hoạt động chuyển thể giống subtilisin, chẳng hạn như phân tích cấu trúc của các protease, các cơ chế đặc hiệu enzyme\u002Fsubstrate, sự tương tác của chúng với các protein khác như 7B2, và sự phân bố mô và tế bào so sánh của các enzyme và các substrate của chúng. Dữ liệu này sau đó được sử dụng làm nền tảng cho việc xem xét các chức năng sinh học đã biết của các chuyển thể pro-protein giống subtilisin, các trường hợp lâm sàng đã báo cáo liên quan đến các khiếm khuyết trong xử lý proteolytic và, cuối cùng, việc phát triển các phân tử ức chế liệu pháp mới dựa trên kiến thức này.\u003C\u002Fjats:p>",{"EN":1401,"VI":1402},"Subtilase-like pro-protein convertases: from molecular specificity to therapeutic applications","Các chuyển thể pro-protein giống subtilase: từ tính đặc hiệu phân tử đến ứng dụng liệu pháp",{"VOID":1404},"10656993",{"VOID":1406},"10.1677\u002Fjme.0.0240001","2024-09-11T19:23:09.525+00:00",[113],[547],"https:\u002F\u002Fjme.bioscientifica.com\u002Fview\u002Fjournals\u002Fjme\u002F24\u002F1\u002F1.xml",[1412,1431,1448],{"id":1413,"sortIndex":25,"researcher":24,"roles":1414,"affiliations":1415,"properties":1424,"displayName":1428,"givenName":24,"familyName":24},"86159143-0226-4a3e-bbd6-23b69423ec94",[],[1416],{"id":1417,"sortIndex":25,"affiliation":1418,"properties":24},"5f2edd12-8013-4a75-ac13-dbb068a1b7dd",{"id":1417,"createTime":24,"updateTime":24,"relativeEntities":1419,"slug":24,"properties":1420,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1423,"statistic":24},[],{"title":1421},{"VI":1422},"Département de Pharmacologie, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, 3001 12e Avenue nord, Sherbrooke, Québec, Canada J1H 5N4",[],{"orcid":1425,"title":1427,"openalex":1429},{"VOID":1426},"https:\u002F\u002Forcid.org\u002F0000-0003-1505-8056",{"EN":1428},"François Bergeron",{"VOID":1430},"A5102846275",{"id":1432,"sortIndex":130,"researcher":24,"roles":1433,"affiliations":1434,"properties":1441,"displayName":1445,"givenName":24,"familyName":24},"bbb84f10-7b26-44f9-a9c3-6400a15a1e27",[],[1435],{"id":1417,"sortIndex":25,"affiliation":1436,"properties":24},{"id":1417,"createTime":24,"updateTime":24,"relativeEntities":1437,"slug":24,"properties":1438,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1440,"statistic":24},[],{"title":1439},{"VI":1422},[],{"orcid":1442,"title":1444,"openalex":1446},{"VOID":1443},"https:\u002F\u002Forcid.org\u002F0000-0001-6854-8003",{"EN":1445},"Richard Leduc",{"VOID":1447},"A5075307650",{"id":1449,"sortIndex":163,"researcher":24,"roles":1450,"affiliations":1451,"properties":1460,"displayName":1464,"givenName":24,"familyName":24},"aa8eb19c-b34f-434b-9fa2-5d4cc6df183e",[],[1452],{"id":1453,"sortIndex":25,"affiliation":1454,"properties":24},"335d02eb-70a0-42fa-96e8-82434a1e3d1a",{"id":1453,"createTime":24,"updateTime":24,"relativeEntities":1455,"slug":24,"properties":1456,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1459,"statistic":24},[],{"title":1457},{"EN":1458},"Universite de sherbrooke",[],{"orcid":1461,"title":1463,"openalex":1465},{"VOID":1462},"https:\u002F\u002Forcid.org\u002F0000-0001-8123-1991",{"EN":1464},"Robert Day",{"VOID":1466},"A5078845932",{"url":24,"publisher":1468,"properties":1505},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1469,"slug":10,"properties":1470,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1475,"manageAffiliations":1484,"indexDatabases":1490,"url":83,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1471,"eissn":1472,"issn":1473,"title":1474},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[1476,1480],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":1477,"label":1478,"description":1479,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":1481,"label":1482,"description":1483,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[1485],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":1486,"slug":24,"properties":1487,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1489,"statistic":24},[],{"title":1488},{"EN":45},[],[1491,1498],{"id":49,"indexDatabase":1492,"url":60,"indexYears":61,"academicFieldIds":1497,"indexDatabaseRanking":65},{"id":51,"createTime":24,"updateTime":24,"relativeEntities":1493,"label":1494,"description":1495,"key":57,"publicationTags":1496,"standard":24},[],{"EN":54,"VI":54},{"EN":54,"VI":56},[59],[63,64],{"id":67,"indexDatabase":1499,"url":80,"indexYears":24,"academicFieldIds":1504,"indexDatabaseRanking":24},{"id":69,"createTime":24,"updateTime":24,"relativeEntities":1500,"label":1501,"description":1502,"key":76,"publicationTags":1503,"standard":24},[],{"EN":72,"VI":72},{"EN":74,"VI":75},[78,79],[82],{"issue":1506,"pages":1507,"volume":1509},{"VOID":244},{"VOID":1508},"1-22",{"VOID":1510},"24",182,{"total":1511,"publishYear":1513,"statisticByYear":1514},2000,{"2012":655,"2013":654,"2014":655,"2015":130,"2016":163,"2017":654,"2018":163,"2019":163,"2020":130,"2022":654,"2023":597,"2024":130},"2000-02-01",[78,65],[],{"id":1519,"createTime":1520,"updateTime":1521,"relativeEntities":1522,"slug":1523,"properties":1524,"entityType":109,"verifyStatus":23,"verifyTime":1520,"verifyNote":544,"languages":1540,"translateLanguages":1541,"viewCount":25,"primaryUrl":1542,"fullTextUrl":24,"authors":1543,"publicationType":203,"publisherRelationship":1599,"citationCount":1643,"citationInfo":1644,"publishDate":1648,"publishYear":1645,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":1649,"openAccess":24,"references":1650,"isForceReanalyzing":519},"939736e0-ce70-4d50-9c59-56f22dcaa8f0","2024-09-24T03:18:37.330+00:00","2025-02-08T04:59:58.165+00:00",[],"Inhibition-of-proliferation-of-prostate-cancer-cells-by-a-19-nor-hexafluoride-vitamin-D3-analogue-involves-the-induction-of-p21waf1-p27kip1-and-E-cadherin",{"mag":1525,"keywords":1527,"openalex":1528,"abstract":1530,"title":1533,"pm":1536,"doi":1538},{"VOID":1526},"2071429904",{"VI":530},{"VOID":1529},"W2071429904",{"EN":1531,"VI":1532},"\u003Cjats:title>ABSTRACT\u003C\u002Fjats:title>\n\u003Cjats:p>We have synthesized and studied the ability of a series of seven novel 1α,25(OH)\u003Cjats:sub>2\u003C\u002Fjats:sub> vitamin D\u003Cjats:sub>3\u003C\u002Fjats:sub> analogues to inhibit clonal growth of prostate cancer cells (LNCaP, PC-3 and DU-145). Addition of double and triple bonds to the C\u002FD ring (C-16) and side chain (C-22 and C-23) as well as lengthening of the side chain were important for enhanced activity against LNCaP and PC-3. Reorientation of the side chain in the 20-epi configuration resulted in analogues that were extremely potent only against LNCaP (ED\u003Cjats:sub>50\u003C\u002Fjats:sub> ≈ 5 × 10\u003Cjats:sup>−11\u003C\u002Fjats:sup> \u003Cjats:sc>m\u003C\u002Fjats:sc>). Compounds with six fluorines on the end of the side chain were very active against both PC-3 and LNCaP (ED\u003Cjats:sub>50\u003C\u002Fjats:sub> ≈ 2 × 10\u003Cjats:sup>−8\u003C\u002Fjats:sup> \u003Cjats:sc>m\u003C\u002Fjats:sc>). DU-145 cells were relatively resistant to compounds with all of these modifications, but removal of C-19 (e.g. 1,25(OH)\u003Cjats:sub>2\u003C\u002Fjats:sub>-16-ene-23-yne-26,27-F\u003Cjats:sub>6\u003C\u002Fjats:sub>-19-nor-D\u003Cjats:sub>3\u003C\u002Fjats:sub>) resulted in an analogue that was inhibitory against all three prostate cell lines. Further analysis showed that pulse exposure (3 days, 10\u003Cjats:sup>−7\u003C\u002Fjats:sup> \u003Cjats:sc>m\u003C\u002Fjats:sc>) to this analogue was enough to inhibit clonal growth of PC-3 cells by 50%. The same exposure also induced cell cycle arrest of all three cell lines, accompanied by upregulated protein expression of the cyclin-dependent kinase inhibitor (CDKI) known as p21\u003Cjats:sup>\u003Cjats:italic>waf1\u003C\u002Fjats:italic>\u003C\u002Fjats:sup> in all three cell lines, and the CDKI known as p27\u003Cjats:sup>\u003Cjats:italic>kip1\u003C\u002Fjats:italic>\u003C\u002Fjats:sup> in LNCaP cells. Associated with upregulation of these CDKIs, partial differentiation occurred as measured by increased expression of both prostate-specific antigen by LNCaP cells and E-cadherin, a cell adhesion protein that may act as a putative tumour suppressor (LNCaP and PC-3 cells). In summary, this is the first report of a potent series of 19-nor-vitamin D\u003Cjats:sub>3\u003C\u002Fjats:sub> analogues with the ability to inhibit proliferation of LNCaP, PC-3 and DU-145 prostate cancer cell lines. These compounds may mediate their potent anti-proliferative activities through a cell cycle arrest pathway.\u003C\u002Fjats:p>","\u003Cjats:title>TÓM TẮT\u003C\u002Fjats:title>\n\u003Cjats:p>Chúng tôi đã tổng hợp và nghiên cứu khả năng của một loạt bảy dẫn xuất mới 1α,25(OH)\u003Cjats:sub>2\u003C\u002Fjats:sub> vitamin D\u003Cjats:sub>3\u003C\u002Fjats:sub> trong việc ức chế sự phát triển nhân giống của các tế bào ung thư tuyến tiền liệt (LNCaP, PC-3 và DU-145). Việc thêm liên kết đôi và ba vào vòng C\u002FD (C-16) và chuỗi bên (C-22 và C-23) cũng như việc kéo dài chuỗi bên rất quan trọng cho hoạt tính tăng cường đối với LNCaP và PC-3. Sự định hướng lại của chuỗi bên trong cấu hình 20-epi dẫn đến các dẫn xuất cực kỳ mạnh chỉ chống lại LNCaP (ED\u003Cjats:sub>50\u003C\u002Fjats:sub> ≈ 5 × 10\u003Cjats:sup>−11\u003C\u002Fjats:sup> \u003Cjats:sc>m\u003C\u002Fjats:sc>). Các hợp chất với sáu fluor ở đầu chuỗi bên có hoạt tính rất mạnh chống lại cả PC-3 và LNCaP (ED\u003Cjats:sub>50\u003C\u002Fjats:sub> ≈ 2 × 10\u003Cjats:sup>−8\u003C\u002Fjats:sup> \u003Cjats:sc>m\u003C\u002Fjats:sc>). Các tế bào DU-145 tương đối kháng với các hợp chất có tất cả các sửa đổi này, nhưng khi loại bỏ C-19 (ví dụ: 1,25(OH)\u003Cjats:sub>2\u003C\u002Fjats:sub>-16-ene-23-yne-26,27-F\u003Cjats:sub>6\u003C\u002Fjats:sub>-19-nor-D\u003Cjats:sub>3\u003C\u002Fjats:sub>) dẫn đến một dẫn xuất có khả năng ức chế tất cả ba dòng tế bào tuyến tiền liệt. Phân tích thêm cho thấy rằng việc phơi nhiễm tạm thời (3 ngày, 10\u003Cjats:sup>−7\u003C\u002Fjats:sup> \u003Cjats:sc>m\u003C\u002Fjats:sc>) với dẫn xuất này đã đủ để ức chế sự phát triển nhân giống của tế bào PC-3 bằng 50%. Phơi nhiễm tương tự cũng gây ra việc kìm hãm chu kỳ tế bào của tất cả ba dòng tế bào, đi kèm với sự tăng cường biểu hiện protein của chất ức chế kinase phụ thuộc cyclin (CDKI) được biết đến với tên gọi p21\u003Cjats:sup>\u003Cjats:italic>waf1\u003C\u002Fjats:italic>\u003C\u002Fjats:sup> trong cả ba dòng tế bào, và CDKI được biết đến với tên gọi p27\u003Cjats:sup>\u003Cjats:italic>kip1\u003C\u002Fjats:italic>\u003C\u002Fjats:sup> trong các tế bào LNCaP. Liên quan đến sự tăng cường các CDKI này, hiện tượng phân hóa một phần xảy ra, được đo bằng việc tăng cường biểu hiện của cả kháng nguyên cụ thể của tuyến tiền liệt ở tế bào LNCaP và E-cadherin, một protein liên kết tế bào có thể hoạt động như một chất ức chế khối u dự kiến (tế bào LNCaP và PC-3). Tóm tắt, đây là báo cáo đầu tiên về một loạt các dẫn xuất 19-nor-vitamin D\u003Cjats:sub>3\u003C\u002Fjats:sub> có khả năng ức chế sự tăng trưởng của các dòng tế bào ung thư tuyến tiền liệt LNCaP, PC-3 và DU-145. Các hợp chất này có thể làm trung gian cho các hoạt động ức chế tăng trưởng mạnh mẽ của chúng thông qua một con đường kìm hãm chu kỳ tế bào.\u003C\u002Fjats:p>",{"EN":1534,"VI":1535},"Inhibition of proliferation of prostate cancer cells by a 19-nor-hexafluoride vitamin D3 analogue involves the induction of p21waf1, p27kip1 and E-cadherin","Sự ức chế sự phát triển của các tế bào ung thư tuyến tiền liệt bởi một dẫn xuất vitamin D3 có 19-nor-hexafluoride liên quan đến sự kích thích p21waf1, p27kip1 và E-cadherin",{"VOID":1537},"9278857",{"VOID":1539},"10.1677\u002Fjme.0.0190015",[113],[547],"https:\u002F\u002Fjme.bioscientifica.com\u002Fview\u002Fjournals\u002Fjme\u002F19\u002F1\u002Fjme_19_1_002.xml",[1544,1563,1572,1581,1590],{"id":1545,"sortIndex":25,"researcher":24,"roles":1546,"affiliations":1547,"properties":1556,"displayName":1560,"givenName":24,"familyName":24},"92a89a2a-b48d-4a89-bda8-afc89c73158a",[],[1548],{"id":1549,"sortIndex":25,"affiliation":1550,"properties":24},"81d2ebcb-dbff-452a-853b-35dbd1698ab7",{"id":1549,"createTime":24,"updateTime":24,"relativeEntities":1551,"slug":24,"properties":1552,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1555,"statistic":24},[],{"title":1553},{"EN":1554},"Division of Hematology\u002FOncology, Cedars-Sinai Medical Center\u002FUCLA School of Medicine 90048, USA.",[],{"orcid":1557,"title":1559,"openalex":1561},{"VOID":1558},"https:\u002F\u002Forcid.org\u002F0000-0002-3355-0928",{"EN":1560},"Moray J. Campbell",{"VOID":1562},"A5060760341",{"id":1564,"sortIndex":130,"researcher":24,"roles":1565,"affiliations":1566,"properties":1567,"displayName":1569,"givenName":24,"familyName":24},"0d75b1ad-b3c6-49c5-a515-ca62e0866f11",[],[],{"title":1568,"openalex":1570},{"EN":1569},"Elena Elstner",{"VOID":1571},"A5073043527",{"id":1573,"sortIndex":163,"researcher":24,"roles":1574,"affiliations":1575,"properties":1576,"displayName":1578,"givenName":24,"familyName":24},"c0680c28-4abf-4156-8f95-6fde798f8db0",[],[],{"title":1577,"openalex":1579},{"EN":1578},"Stuart Holden",{"VOID":1580},"A5076964171",{"id":1582,"sortIndex":587,"researcher":24,"roles":1583,"affiliations":1584,"properties":1585,"displayName":1587,"givenName":24,"familyName":24},"3fc38624-cebc-4778-9961-9ce83e6a00de",[],[],{"title":1586,"openalex":1588},{"EN":1587},"Milan R. Uskoković",{"VOID":1589},"A5034479183",{"id":1591,"sortIndex":597,"researcher":24,"roles":1592,"affiliations":1593,"properties":1594,"displayName":1596,"givenName":24,"familyName":24},"bbf9e4cb-45f0-4e39-8b07-838dfb8a40e0",[],[],{"title":1595,"openalex":1597},{"EN":1596},"H P Koeffler",{"VOID":1598},"A5044012656",{"url":24,"publisher":1600,"properties":1637},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1601,"slug":10,"properties":1602,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1607,"manageAffiliations":1616,"indexDatabases":1622,"url":83,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1603,"eissn":1604,"issn":1605,"title":1606},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[1608,1612],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":1609,"label":1610,"description":1611,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":1613,"label":1614,"description":1615,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[1617],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":1618,"slug":24,"properties":1619,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1621,"statistic":24},[],{"title":1620},{"EN":45},[],[1623,1630],{"id":49,"indexDatabase":1624,"url":60,"indexYears":61,"academicFieldIds":1629,"indexDatabaseRanking":65},{"id":51,"createTime":24,"updateTime":24,"relativeEntities":1625,"label":1626,"description":1627,"key":57,"publicationTags":1628,"standard":24},[],{"EN":54,"VI":54},{"EN":54,"VI":56},[59],[63,64],{"id":67,"indexDatabase":1631,"url":80,"indexYears":24,"academicFieldIds":1636,"indexDatabaseRanking":24},{"id":69,"createTime":24,"updateTime":24,"relativeEntities":1632,"label":1633,"description":1634,"key":76,"publicationTags":1635,"standard":24},[],{"EN":72,"VI":72},{"EN":74,"VI":75},[78,79],[82],{"issue":1638,"pages":1639,"volume":1641},{"VOID":244},{"VOID":1640},"15-27",{"VOID":1642},"19",189,{"total":1643,"publishYear":1645,"statisticByYear":1646},1997,{"2012":1647,"2013":597,"2014":932,"2015":587,"2016":655,"2017":654,"2018":587,"2019":597,"2020":597,"2021":654,"2022":587,"2023":163,"2024":163},10,"1997-08-01",[78,65],[],{"id":1652,"createTime":1653,"updateTime":1654,"relativeEntities":1655,"slug":1656,"properties":1657,"entityType":109,"verifyStatus":23,"verifyTime":1674,"verifyNote":544,"languages":1675,"translateLanguages":1676,"viewCount":25,"primaryUrl":1677,"fullTextUrl":24,"authors":1678,"publicationType":203,"publisherRelationship":1705,"citationCount":1749,"citationInfo":1750,"publishDate":1754,"publishYear":1751,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":1755,"openAccess":24,"references":1756,"isForceReanalyzing":519},"1ee73560-8914-41dd-892e-5c8d02970f6e","2024-09-13T02:16:33.978+00:00","2025-02-08T04:58:58.422+00:00",[],"Peroxisome-proliferator-activated-receptor-alpha-role-in-rodent-liver-cancer-and-species-differences",{"mag":1658,"keywords":1660,"openalex":1662,"abstract":1664,"title":1667,"pm":1670,"doi":1672},{"VOID":1659},"2065624367",{"VI":1661},"Peroxisome proliferators, PPARalpha, ung thư gan, động vật gặm nhấm, sự khác biệt giữa các loài",{"VOID":1663},"W2065624367",{"EN":1665,"VI":1666},"\u003Cjats:p>Peroxisome proliferators (PPs) are chemicals of industrial and pharmaceutical importance that elicit liver carcinogenesis by a non-genotoxic mechanism. One of the intriguing properties of PPs is that the pleiotropic effects of these compounds (including increased DNA synthesis and peroxisome proliferation) are seen in rats and mice only, but not humans. It is important to determine the risks to humans of environmental and therapeutic exposure to these compounds by understanding the mechanisms of non-genotoxic hepatocarcinogenesis in rodents. To understand this apparent lack of human susceptibility, attention has focused on the peroxisome proliferator-activated receptor alpha (PPARalpha), which appears to mediate the effects of PPs in rodents. It is also known to mediate the hypolipidaemic effects that fibrate drugs exert on humans with elevated plasma cholesterol and triglyceride levels. Human PPARalphas share many functional characteristics with the rodent receptors, in that they can be transcriptionally activated by PPs and regulate specific gene expression. However, one key difference is that PPARalpha is less abundant in human than in rodent liver, which has led to the suggestion that species differences result from quantitative differences in gene expression. In this review we describe the effects of PPs and what is known of the molecular mechanisms of action and species differences with respect to rodents and man. Attention will be given to differences in the amounts of PPARalpha between species as well as the 'qualitative' aspects of PPARalpha-mediated gene regulation which might also explain the activation of some genes and not of others in human liver by PPs.\u003C\u002Fjats:p>","\u003Cjats:p>Các chất kích thích peroxisome (PPs) là hóa chất có tầm quan trọng trong công nghiệp và dược phẩm, gây ra ung thư gan qua cơ chế không di truyền. Một trong những đặc tính thú vị của PPs là các tác động đa dạng của những hợp chất này (bao gồm cả việc tăng tổng hợp DNA và sự tăng sinh peroxisome) chỉ được quan sát ở chuột và chuột lang, mà không có ở người. Việc hiểu rõ các nguy cơ đối với con người từ việc tiếp xúc với các hợp chất này trong môi trường và điều trị rất quan trọng, và điều này phụ thuộc vào việc hiểu các cơ chế ung thư gan không di truyền ở động vật gặm nhấm. Để hiểu sự thiếu nhạy cảm rõ rệt này ở con người, chú ý đã được hướng tới thụ thể được hoạt hóa bởi peroxisome proliferator alpha (PPARalpha), thụ thể này dường như trung gian cho các tác động của PPs ở gặm nhấm. Nó cũng được biết đến để trung gian cho các tác động hạ lipid máu mà các thuốc fibrate gây ra ở người có mức cholesterol và triglyceride huyết tương cao. Các thụ thể PPARalpha ở người có nhiều đặc điểm chức năng giống với các thụ thể ở động vật gặm nhấm, ở chỗ chúng có thể được kích hoạt phiên mã bởi PPs và điều chỉnh sự biểu hiện của một số gen nhất định. Tuy nhiên, một sự khác biệt chính là PPARalpha ít phong phú hơn ở gan người so với gan gặm nhấm, điều này đã dẫn đến gợi ý rằng sự khác biệt giữa các loài xuất phát từ sự khác biệt định lượng trong sự biểu hiện gene. Trong bài đánh giá này, chúng tôi mô tả các tác động của PPs và những gì được biết về các cơ chế tác động phân tử cũng như sự khác biệt giữa các loài liên quan đến gặm nhấm và con người. Sẽ chú ý đến sự khác biệt về lượng PPARalpha giữa các loài cũng như các khía cạnh 'chất lượng' trong việc điều chỉnh gene do PPARalpha trung gian, điều này cũng có thể giải thích việc kích hoạt một số gen và không kích hoạt những gen khác trong gan người do PPs gây ra.\u003C\u002Fjats:p>",{"EN":1668,"VI":1669},"Peroxisome proliferator-activated receptor alpha: role in rodent liver cancer and species differences","Thụ thể được hoạt hóa bởi peroxisome proliferator alpha: vai trò trong ung thư gan ở gặm nhấm và sự khác biệt giữa các loài",{"VOID":1671},"9924174",{"VOID":1673},"10.1677\u002Fjme.0.0220001","2024-09-13T02:16:33.977+00:00",[113],[547],"https:\u002F\u002Fjme.bioscientifica.com\u002Fview\u002Fjournals\u002Fjme\u002F22\u002F1\u002F1.xml",[1679,1696],{"id":1680,"sortIndex":25,"researcher":24,"roles":1681,"affiliations":1682,"properties":1691,"displayName":1693,"givenName":24,"familyName":24},"f0b96ea1-4b97-4109-b08a-91d1155ab736",[],[1683],{"id":1684,"sortIndex":25,"affiliation":1685,"properties":24},"ddf59852-c793-4c6e-be50-16d336592ae5",{"id":1684,"createTime":24,"updateTime":24,"relativeEntities":1686,"slug":24,"properties":1687,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1690,"statistic":24},[],{"title":1688},{"VI":1689},"Zeneca Central Toxicology Laboratory, Alderley Park, Macclesfield, SK10 4TJ, UK",[],{"title":1692,"openalex":1694},{"EN":1693},"Peter R. Holden",{"VOID":1695},"A5022177451",{"id":1697,"sortIndex":130,"researcher":24,"roles":1698,"affiliations":1699,"properties":1700,"displayName":1702,"givenName":24,"familyName":24},"32f87f32-f83d-4c80-a24f-d848e8c390b7",[],[],{"title":1701,"openalex":1703},{"EN":1702},"J D Tugwood",{"VOID":1704},"A5071768701",{"url":24,"publisher":1706,"properties":1743},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1707,"slug":10,"properties":1708,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1713,"manageAffiliations":1722,"indexDatabases":1728,"url":83,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1709,"eissn":1710,"issn":1711,"title":1712},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[1714,1718],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":1715,"label":1716,"description":1717,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":1719,"label":1720,"description":1721,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[1723],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":1724,"slug":24,"properties":1725,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1727,"statistic":24},[],{"title":1726},{"EN":45},[],[1729,1736],{"id":49,"indexDatabase":1730,"url":60,"indexYears":61,"academicFieldIds":1735,"indexDatabaseRanking":65},{"id":51,"createTime":24,"updateTime":24,"relativeEntities":1731,"label":1732,"description":1733,"key":57,"publicationTags":1734,"standard":24},[],{"EN":54,"VI":54},{"EN":54,"VI":56},[59],[63,64],{"id":67,"indexDatabase":1737,"url":80,"indexYears":24,"academicFieldIds":1742,"indexDatabaseRanking":24},{"id":69,"createTime":24,"updateTime":24,"relativeEntities":1738,"label":1739,"description":1740,"key":76,"publicationTags":1741,"standard":24},[],{"EN":72,"VI":72},{"EN":74,"VI":75},[78,79],[82],{"issue":1744,"pages":1745,"volume":1747},{"VOID":244},{"VOID":1746},"1-8",{"VOID":1748},"22",198,{"total":1749,"publishYear":1751,"statisticByYear":1752},1999,{"2012":259,"2013":932,"2014":655,"2015":654,"2016":587,"2017":1753,"2018":932,"2019":1753,"2020":655,"2021":597,"2022":597,"2023":654,"2024":130},7,"1999-02-01",[78,65],[],{"id":1758,"createTime":1759,"updateTime":1760,"relativeEntities":1761,"slug":1762,"properties":1763,"entityType":109,"verifyStatus":23,"verifyTime":1759,"verifyNote":544,"languages":1779,"translateLanguages":1780,"viewCount":25,"primaryUrl":1781,"fullTextUrl":24,"authors":1782,"publicationType":203,"publisherRelationship":1822,"citationCount":1866,"citationInfo":1867,"publishDate":1870,"publishYear":1868,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":1871,"openAccess":24,"references":1872,"isForceReanalyzing":519},"4b9bded3-48ae-4392-8cba-16fbe26fab0f","2024-09-03T03:08:43.517+00:00","2025-02-08T04:57:58.981+00:00",[],"Peroxisome-proliferator-activated-receptor-gamma-from-adipogenesis-to-carcinogenesis",{"mag":1764,"keywords":1766,"openalex":1767,"abstract":1769,"title":1772,"pm":1775,"doi":1777},{"VOID":1765},"2158609897",{"VI":530},{"VOID":1768},"W2158609897",{"EN":1770,"VI":1771},"\u003Cjats:p>Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for synthetic compounds inducing peroxisome proliferation. PPAR-gamma, the best characterized of the PPARs, plays a crucial role in adipogenesis and insulin sensitization. Furthermore, PPAR-gamma has been reported to affect cell proliferation\u002Fdifferentiation pathways in various malignancies. We discuss in the present review recent advances in the understanding of the function of PPAR-gamma in both cell proliferation and adipocyte differentiation.\u003C\u002Fjats:p>","\u003Cjats:p>Các thụ thể kích hoạt peroxisome proliferator (PPARs) là các thụ thể hormon hạt nhân, được miêu tả lần đầu tiên như là các mục tiêu phân tử cho các hợp chất tổng hợp gây ra sự gia tăng peroxisome. PPAR-gamma, thụ thể được nghiên cứu kĩ lưỡng nhất trong số các PPARs, đóng vai trò quan trọng trong quá trình sinh adipose và tăng cường độ nhạy insulin. Hơn nữa, PPAR-gamma đã được báo cáo là có ảnh hưởng đến các con đường phân chia\u002Ftuyến hóa tế bào trong nhiều loại ác tính khác nhau. Trong bài viết này, chúng tôi sẽ thảo luận về các tiến bộ gần đây trong việc hiểu biết chức năng của PPAR-gamma trong cả quá trình phân chia tế bào và phân hóa tế bào mỡ.\u003C\u002Fjats:p>",{"EN":1773,"VI":1774},"Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis","Thụ thể kích hoạt peroxisome proliferator-gamma: từ sinh adipose đến ung thư sinh",{"VOID":1776},"11463572",{"VOID":1778},"10.1677\u002Fjme.0.0270001",[113],[547],"https:\u002F\u002Fjme.bioscientifica.com\u002Fview\u002Fjournals\u002Fjme\u002F27\u002F1\u002F1.xml",[1783,1794,1803],{"id":1784,"sortIndex":25,"researcher":24,"roles":1785,"affiliations":1786,"properties":1787,"displayName":1791,"givenName":24,"familyName":24},"8ba3db89-b008-4dbf-9784-af602721ff63",[],[],{"orcid":1788,"title":1790,"openalex":1792},{"VOID":1789},"https:\u002F\u002Forcid.org\u002F0000-0002-1283-9503",{"EN":1791},"Lluís Fajas",{"VOID":1793},"A5009899895",{"id":1795,"sortIndex":130,"researcher":24,"roles":1796,"affiliations":1797,"properties":1798,"displayName":1800,"givenName":24,"familyName":24},"b7ced426-2be0-4bb4-936d-ce1cb656f7bd",[],[],{"title":1799,"openalex":1801},{"EN":1800},"M B Debril",{"VOID":1802},"A5068698974",{"id":1804,"sortIndex":163,"researcher":24,"roles":1805,"affiliations":1806,"properties":1815,"displayName":1819,"givenName":24,"familyName":24},"0dc24735-ace1-483d-8899-2e8a5fe9a2e0",[],[1807],{"id":1808,"sortIndex":25,"affiliation":1809,"properties":24},"8ee6c33f-44a4-4720-ab40-c0bb9da4371c",{"id":1808,"createTime":24,"updateTime":24,"relativeEntities":1810,"slug":24,"properties":1811,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1814,"statistic":24},[],{"title":1812},{"EN":1813},"Institut de Génétique et de Biologie Moléculaire et Cellulaire",[],{"orcid":1816,"title":1818,"openalex":1820},{"VOID":1817},"https:\u002F\u002Forcid.org\u002F0000-0002-5065-5393",{"EN":1819},"Johan Auwerx",{"VOID":1821},"A5003154600",{"url":24,"publisher":1823,"properties":1860},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1824,"slug":10,"properties":1825,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1830,"manageAffiliations":1839,"indexDatabases":1845,"url":83,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1826,"eissn":1827,"issn":1828,"title":1829},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[1831,1835],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":1832,"label":1833,"description":1834,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":1836,"label":1837,"description":1838,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[1840],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":1841,"slug":24,"properties":1842,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1844,"statistic":24},[],{"title":1843},{"EN":45},[],[1846,1853],{"id":49,"indexDatabase":1847,"url":60,"indexYears":61,"academicFieldIds":1852,"indexDatabaseRanking":65},{"id":51,"createTime":24,"updateTime":24,"relativeEntities":1848,"label":1849,"description":1850,"key":57,"publicationTags":1851,"standard":24},[],{"EN":54,"VI":54},{"EN":54,"VI":56},[59],[63,64],{"id":67,"indexDatabase":1854,"url":80,"indexYears":24,"academicFieldIds":1859,"indexDatabaseRanking":24},{"id":69,"createTime":24,"updateTime":24,"relativeEntities":1855,"label":1856,"description":1857,"key":76,"publicationTags":1858,"standard":24},[],{"EN":72,"VI":72},{"EN":74,"VI":75},[78,79],[82],{"issue":1861,"pages":1862,"volume":1864},{"VOID":244},{"VOID":1863},"1-9",{"VOID":1865},"27",228,{"total":1866,"publishYear":1868,"statisticByYear":1869},2001,{"2012":1647,"2013":1647,"2014":655,"2015":597,"2016":163,"2017":587,"2018":597,"2019":597,"2020":654,"2021":597,"2022":163,"2023":654,"2024":130},"2001-08-01",[78,65],[],{"id":1874,"createTime":1875,"updateTime":1876,"relativeEntities":1877,"slug":1878,"properties":1879,"entityType":109,"verifyStatus":110,"verifyTime":1875,"verifyNote":111,"languages":1895,"translateLanguages":1896,"viewCount":25,"primaryUrl":1897,"fullTextUrl":24,"authors":1898,"publicationType":203,"publisherRelationship":1992,"citationCount":2036,"citationInfo":2037,"publishDate":2041,"publishYear":1751,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":2042,"openAccess":24,"references":2043,"isForceReanalyzing":519},"f966c3fb-27e9-474a-a93e-dc6a4c04ca7e","2024-09-17T23:31:54.542+00:00","2025-02-08T04:57:03.431+00:00",[],"Suppression-of-P450-aromatase-gene-expression-in-sex-reversed-males-produced-by-rearing-genetically-female-larvae-at-a-high-water-temperature-during-a-period-of-sex-differentiation-in-the-Japanese-flounder-Paralichthys-olivaceus-",{"mag":1880,"keywords":1882,"openalex":1883,"abstract":1885,"title":1888,"pm":1891,"doi":1893},{"VOID":1881},"2103312893",{"VI":530},{"VOID":1884},"W2103312893",{"EN":1886,"VI":1887},"\u003Cjats:p>The phenotypic sex of many teleost fishes including flounders can be experimentally altered by treating embryos or larvae with varied temperatures or sex-steroid hormones. To analyse the sex determination mechanism, especially the role of cytochrome P450 aromatase (P450arom), an enzyme that catalyses the conversion of androgens to estrogens, in temperature-dependent gonadal sex differentiation in the Japanese flounder, we generated two populations of larvae, both having XX (genetic females) but each growing up to display all phenotypic females or males, by rearing the larvae at normal (18 degrees C) or high (27 degrees C) water temperatures from days 30 to 100 after hatching respectively. The larvae (XX) were produced artificially by mating normal females (XX) with gynogenetic diploid males (XX) which had been sex-reversed to phenotypic males by 17alpha-methyltestosterone. To study the role of P450arom in sex determination in the flounder, we first isolated a P450arom cDNA containing the complete open reading frame from the ovary. RT-PCR showed that P450arom mRNA was highly expressed in the ovary and spleen but weakly in the testis and brain. Semi-quantitative analyses of P450arom mRNA in gonads during sex differentiation showed that there was no difference in the levels of P450arom mRNA between the female and male groups when the gonad was sexually indifferent (day 50 after hatching). However, after the initiation of sex differentiation (day 60), the mRNA levels increased rapidly in the female group, whereas they decreased slightly in the male group. Similarly, estradiol-17beta levels rose remarkably in the female group, yet remained constant in the male group. These results suggest that induction of sex reversal of genetically female larvae to phenotypic males by rearing them at a high water temperature caused a suppression of P450arom gene expression. Furthermore, we suggest that the maintenance of P450arom mRNA at very low levels is a prerequisite for testicular differentiation, while the increased levels are indispensable for ovarian differentiation.\u003C\u002Fjats:p>","\u003Cjats:p>Giới tính kiểu hình của nhiều loài cá vây tia, bao gồm cả cá bơn, có thể được thay đổi một cách thực nghiệm bằng cách điều trị phôi hoặc ấu trùng dưới các nhiệt độ khác nhau hoặc hormone steroid giới tính. Để phân tích cơ chế xác định giới tính, đặc biệt là vai trò của cytochrome P450 aromatase (P450arom), một loại enzyme xúc tác chuyển đổi các androgen thành estrogen, trong sự khác biệt giới tính của tuyến sinh dục phụ thuộc vào nhiệt độ ở cá bơn Nhật Bản, chúng tôi đã tạo ra hai quần thể ấu trùng, cả hai đều có kiểu gen XX (cái di truyền) nhưng mỗi quần thể lớn lên để biểu hiện tất cả là cái kiểu hình hoặc đực kiểu hình, bằng cách nuôi dưỡng ấu trùng ở nhiệt độ nước bình thường (18 độ C) hoặc cao (27 độ C) từ ngày 30 đến 100 sau khi nở. Những ấu trùng (XX) được sản xuất nhân tạo bằng cách giao phối giữa những con cái bình thường (XX) với những con đực lưỡng bội sinh sản (XX) đã bị chuyển giới thành đực kiểu hình bằng 17alpha-methyltestosterone. Để nghiên cứu vai trò của P450arom trong xác định giới tính ở cá bơn, chúng tôi đã phân lập một cDNA P450arom chứa khung đọc mở hoàn chỉnh từ buồng trứng. RT-PCR cho thấy mRNA P450arom được biểu hiện cao ở buồng trứng và lách nhưng chỉ yếu ở tinh hoàn và não. Phân tích bán định lượng mRNA P450arom trong các tuyến sinh dục trong quá trình phân hóa giới tính cho thấy không có sự khác biệt về mức độ mRNA P450arom giữa nhóm cái và nhóm đực khi tuyến sinh dục còn không phân biệt giới tính (ngày 50 sau khi nở). Tuy nhiên, sau khi bắt đầu phân hóa giới tính (ngày 60), mức độ mRNA tăng nhanh chóng ở nhóm cái, trong khi chúng giảm nhẹ ở nhóm đực. Tương tự, mức estradiol-17beta tăng đáng kể ở nhóm cái, trong khi vẫn không thay đổi ở nhóm đực. Những kết quả này gợi ý rằng việc chuyển giới những ấu trùng cái di truyền thành đực kiểu hình bằng cách nuôi dưỡng chúng ở nhiệt độ nước cao đã gây ra sự ức chế biểu hiện gen P450arom. Hơn nữa, chúng tôi cho rằng việc duy trì mRNA P450arom ở mức rất thấp là điều kiện cần thiết cho sự phân hóa tinh hoàn, trong khi mức độ tăng là không thể thiếu cho sự phân hóa buồng trứng.\u003C\u002Fjats:p>",{"EN":1889,"VI":1890},"Suppression of P450 aromatase gene expression in sex-reversed males produced by rearing genetically female larvae at a high water temperature during a period of sex differentiation in the Japanese flounder (Paralichthys olivaceus)","Sự ức chế biểu hiện gen P450 aromatase ở những con đực chuyển giới được sản xuất bằng cách nuôi dưỡng ấu trùng cái di truyền ở nhiệt độ nước cao trong giai đoạn phân hóa giới tính ở cá bơn Nhật Bản (Paralichthys olivaceus)",{"VOID":1892},"10514554",{"VOID":1894},"10.1677\u002Fjme.0.0230167",[113],[547],"https:\u002F\u002Fjme.bioscientifica.com\u002Fview\u002Fjournals\u002Fjme\u002F23\u002F2\u002F167.xml",[1899,1926,1945,1964,1977],{"id":1900,"sortIndex":25,"researcher":24,"roles":1901,"affiliations":1902,"properties":1919,"displayName":1923,"givenName":24,"familyName":24},"7e7973cb-8da3-4f85-92a5-d933bb30c5c0",[],[1903,1911],{"id":1904,"sortIndex":25,"affiliation":1905,"properties":24},"1cd97265-1463-4184-829e-ede1e9ef62aa",{"id":1904,"createTime":24,"updateTime":24,"relativeEntities":1906,"slug":24,"properties":1907,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1910,"statistic":24},[],{"title":1908},{"VI":1909},"Department of Materials and Life Science, Graduate School of Science and Technology, Kumamoto University, Kumamoto 860-8555, 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