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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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Technique studies including CRISPR or gene editing are also encouraged.","PENDING",[886,892],{"id":887,"createTime":28,"updateTime":28,"relativeEntities":888,"label":889,"description":891,"parentId":28,"standard":28,"scholarHubFieldId":28},"e28d6c37-225c-41f9-829b-a62e54bf45c7",[],{"EN":890},"Molecular Biology",{},{"id":893,"createTime":28,"updateTime":28,"relativeEntities":894,"label":895,"description":897,"parentId":28,"standard":28,"scholarHubFieldId":28},"9d9ee0b8-275d-4715-80d5-b489aa93b426",[],{"EN":896},"Endocrinology",{},[899],{"id":900,"createTime":28,"updateTime":28,"relativeEntities":901,"slug":28,"properties":902,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":905,"statistic":28},"c924e9f9-6359-4ddf-a6d1-98aa567b0470",[],{"title":903},{"EN":904},"BioScientifica Ltd.",[],[907,920],{"id":908,"indexDatabase":909,"url":914,"indexYears":915,"academicFieldIds":916,"indexDatabaseRanking":919},"ba798dfb-d9f1-470a-8ce8-06a2961f4e98",{"id":775,"createTime":28,"updateTime":28,"relativeEntities":910,"label":911,"description":912,"key":781,"publicationTags":913,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],"https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F26176","1988-2025",[917,918],"0404956d-7818-4510-b67a-db80799a6ec0","1fbd0674-a1cb-4227-af17-9260dd767b86","SCOPUS__Q1",{"id":921,"indexDatabase":922,"url":933,"indexYears":28,"academicFieldIds":934,"indexDatabaseRanking":28},"3bc857c2-87ad-45cf-b536-a3562b9a05d1",{"id":923,"createTime":28,"updateTime":28,"relativeEntities":924,"label":925,"description":927,"key":930,"publicationTags":931,"standard":28},"a4921856-b128-4d9f-8f1f-e80813d3bbd4",[],{"EN":926,"VI":926},"ISI\u002FSCIE - Science Citation Index Expanded",{"EN":928,"VI":929},"SCIE database","Cơ sở dữ liệu SCIE","scie",[932,813],"SCIE","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=0952-5041",[935],"7fc7f180-3918-45ab-8bea-b2226f5d88f6","http:\u002F\u002Fjme.endocrinology-journals.org\u002F",{"meta":938,"data":940},{"total":939},"66",[941,1049,1148,1321,1735,1851,1955,2086,2217,2794],{"id":942,"createTime":943,"updateTime":944,"relativeEntities":945,"slug":946,"properties":947,"entityType":964,"verifyStatus":26,"verifyTime":943,"verifyNote":965,"languages":966,"translateLanguages":967,"viewCount":32,"primaryUrl":968,"fullTextUrl":28,"authors":969,"publicationType":989,"publisherRelationship":990,"citationCount":1035,"citationInfo":1036,"publishDate":1045,"publishYear":1037,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":1046,"openAccess":28,"references":1047,"isForceReanalyzing":1048},"5e0a2f79-83db-4eb4-9d4c-1cfe64f19e42","2024-10-16T03:17:02.981+00:00","2024-12-30T01:25:12.213+00:00",[],"Absolute-quantification-of-mRNA-using-real-time-reverse-transcription-polymerase-chain-reaction-assays",{"mag":948,"keywords":950,"openalex":952,"abstract":954,"title":957,"pm":960,"doi":962},{"VOID":949},"2143146123",{"VI":951},"RT-PCR, định lượng mRNA, phiên mã, gen housekeeping, động học",{"VOID":953},"W2143146123",{"EN":955,"VI":956},"\u003Cjats:p>The reverse transcription polymerase chain reaction (RT-PCR) is the most sensitive method for the detection of low-abundance mRNA, often obtained from limited tissue samples. However, it is a complex technique, there are substantial problems associated with its true sensitivity, reproducibility and specificity and, as a quantitative method, it suffers from the problems inherent in PCR. The recent introduction of fluorescence-based kinetic RT-PCR procedures significantly simplifies the process of producing reproducible quantification of mRNAs and promises to overcome these limitations. Nevertheless, their successful application depends on a clear understanding of the practical problems, and careful experimental design, application and validation remain essential for accurate quantitative measurements of transcription. This review discusses the technical aspects involved, contrasts conventional and kinetic RT-PCR methods for quantitating gene expression and compares the different kinetic RT-PCR systems. It illustrates the usefulness of these assays by demonstrating the significantly different levels of transcription between individuals of the housekeeping gene family, glyceraldehyde-3-phosphate-dehydrogenase (GAPDH).\u003C\u002Fjats:p>","\u003Cjats:p>Phản ứng chuỗi polymerase phiên mã ngược (RT-PCR) là phương pháp nhạy nhất để phát hiện mRNA với số lượng thấp, thường thu được từ các mẫu mô hạn chế. Tuy nhiên, đây là một kỹ thuật phức tạp, có nhiều vấn đề đáng kể liên quan đến độ nhạy, tính tái sản xuất và tính đặc hiệu của nó, và với tư cách là một phương pháp định lượng, nó gặp phải những vấn đề vốn có trong PCR. Sự ra đời gần đây của các quy trình RT-PCR động học dựa trên huỳnh quang đã đơn giản hóa đáng kể quá trình tạo ra sự định lượng mRNA tái sản xuất và hứa hẹn sẽ khắc phục những hạn chế này. Tuy nhiên, việc áp dụng thành công của chúng phụ thuộc vào sự hiểu biết rõ ràng về các vấn đề thực tiễn, và thiết kế thí nghiệm, ứng dụng và xác thực cẩn thận vẫn là điều cần thiết để đo lường định lượng chính xác sự phiên mã. Bài đánh giá này thảo luận về các khía cạnh kỹ thuật liên quan, tương phản giữa các phương pháp RT-PCR thông thường và động học trong việc định lượng biểu hiện gen và so sánh các hệ thống RT-PCR động học khác nhau. Nó minh họa sự hữu ích của những xét nghiệm này bằng cách chứng minh sự khác biệt đáng kể về mức độ phiên mã giữa các cá thể trong họ gen housekeeping, dehydrogenase glyceraldehyde-3-phosphate (GAPDH).\u003C\u002Fjats:p>",{"EN":958,"VI":959},"Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays","Định lượng tuyệt đối mRNA sử dụng xét nghiệm phản ứng chuỗi polymerase phiên mã ngược thời gian thực",{"VOID":961},"11013345",{"VOID":963},"10.1677\u002Fjme.0.0250169","PUBLICATION","Auto Verify",[31],[30],"https:\u002F\u002Fjme.bioscientifica.com\u002Fview\u002Fjournals\u002Fjme\u002F25\u002F2\u002F169.xml",[970],{"id":971,"sortIndex":32,"researcher":28,"roles":972,"affiliations":973,"properties":982,"displayName":986,"givenName":28,"familyName":28},"b55b3aa0-02a3-4223-8a94-30d71f678a14",[],[974],{"id":975,"sortIndex":32,"affiliation":976,"properties":28},"27bb4d09-3bbe-4c3c-bd8d-7587d87ebfc7",{"id":975,"createTime":28,"updateTime":28,"relativeEntities":977,"slug":28,"properties":978,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":981,"statistic":28},[],{"title":979},{"EN":980},"Academic Department of Surgery, St Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London E1 1BB, UK.",[],{"orcid":983,"title":985,"openalex":987},{"VOID":984},"https:\u002F\u002Forcid.org\u002F0000-0003-1870-6098",{"EN":986},"Stephen A. Bustin",{"VOID":988},"A5043596447","ARTICLE",{"url":28,"publisher":991,"properties":1028},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":992,"slug":872,"properties":993,"entityType":25,"verifyStatus":884,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":998,"manageAffiliations":1007,"indexDatabases":1013,"url":936,"thumbnailPath":28,"statistic":28,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"country":994,"eissn":995,"issn":996,"title":997},{"VOID":875},{"VOID":877},{"VOID":879},{"EN":881},[999,1003],{"id":887,"createTime":28,"updateTime":28,"relativeEntities":1000,"label":1001,"description":1002,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},{"id":893,"createTime":28,"updateTime":28,"relativeEntities":1004,"label":1005,"description":1006,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":896},{},[1008],{"id":900,"createTime":28,"updateTime":28,"relativeEntities":1009,"slug":28,"properties":1010,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1012,"statistic":28},[],{"title":1011},{"EN":904},[],[1014,1021],{"id":908,"indexDatabase":1015,"url":914,"indexYears":915,"academicFieldIds":1020,"indexDatabaseRanking":919},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":1016,"label":1017,"description":1018,"key":781,"publicationTags":1019,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[917,918],{"id":921,"indexDatabase":1022,"url":933,"indexYears":28,"academicFieldIds":1027,"indexDatabaseRanking":28},{"id":923,"createTime":28,"updateTime":28,"relativeEntities":1023,"label":1024,"description":1025,"key":930,"publicationTags":1026,"standard":28},[],{"EN":926,"VI":926},{"EN":928,"VI":929},[932,813],[935],{"issue":1029,"pages":1031,"volume":1033},{"VOID":1030},"2",{"VOID":1032},"169-193",{"VOID":1034},"25",3850,{"total":1035,"publishYear":1037,"statisticByYear":1038},2000,{"2012":1039,"2013":1040,"2014":1041,"2015":1042,"2016":1043,"2017":1044,"2018":334,"2019":155,"2020":354,"2021":330,"2022":330,"2023":826,"2024":137},209,214,170,141,137,108,"2000-10-01",[932,919],[],false,{"id":1050,"createTime":1051,"updateTime":1052,"relativeEntities":1053,"slug":1054,"properties":1055,"entityType":964,"verifyStatus":26,"verifyTime":1051,"verifyNote":965,"languages":1072,"translateLanguages":1073,"viewCount":32,"primaryUrl":1074,"fullTextUrl":28,"authors":1075,"publicationType":989,"publisherRelationship":1092,"citationCount":1137,"citationInfo":1138,"publishDate":1145,"publishYear":1139,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":1146,"openAccess":28,"references":1147,"isForceReanalyzing":1048},"8f5b5640-8f08-448d-9bb8-0f0352ce0007","2024-09-27T03:06:38.031+00:00","2024-12-26T07:00:37.892+00:00",[],"Quantification-of-mRNA-using-real-time-reverse-transcription-PCR-RT-PCR-trends-and-problems",{"mag":1056,"keywords":1058,"openalex":1060,"abstract":1062,"title":1065,"pm":1068,"doi":1070},{"VOID":1057},"2112982595",{"VI":1059},"PCR ngược dòng thời gian thực, định lượng mRNA, huỳnh quang, nghiêm ngặt, thống kê, y học phân tử, công nghệ sinh học, biến đổi hóa chất, xu hướng, vấn đề",{"VOID":1061},"W2112982595",{"EN":1063,"VI":1064},"\u003Cjats:p>The fluorescence-based real-time reverse transcription PCR (RT-PCR) is widely used for the quantification of steady-state mRNA levels and is a critical tool for basic research, molecular medicine and biotechnology. Assays are easy to perform, capable of high throughput, and can combine high sensitivity with reliable specificity. The technology is evolving rapidly with the introduction of new enzymes, chemistries and instrumentation. However, while real-time RT-PCR addresses many of the difficulties inherent in conventional RT-PCR, it has become increasingly clear that it engenders new problems that require urgent attention. Therefore, in addition to providing a snapshot of the state-of-the-art in real-time RT-PCR, this review has an additional aim: it will describe and discuss critically some of the problems associated with interpreting results that are numerical and lend themselves to statistical analysis, yet whose accuracy is significantly affected by reagent and operator variability.\u003C\u002Fjats:p>","\u003Cjats:p>Phương pháp PCR Ngược Dòng Thời gian Thực dựa trên huỳnh quang (RT-PCR) được sử dụng rộng rãi để định lượng mức mRNA ở trạng thái ổn định và là một công cụ quan trọng cho nghiên cứu cơ bản, y học phân tử và công nghệ sinh học. Các thử nghiệm dễ tiến hành, có khả năng xử lý khối lượng lớn, và có thể kết hợp độ nhạy cao với độ đặc hiệu đáng tin cậy. Công nghệ này đang tiến hóa nhanh chóng với sự xuất hiện của các enzym, hóa chất và thiết bị mới. Tuy nhiên, mặc dù RT-PCR thời gian thực đã giải quyết nhiều khó khăn vốn có trong RT-PCR thông thường, nó đã trở nên ngày càng rõ ràng rằng nó tạo ra những vấn đề mới cần giải quyết cấp thiết. Do đó, bên cạnh việc cung cấp bức tranh tổng thể về công nghệ RT-PCR thời gian thực, bài đánh giá này còn có mục tiêu bổ sung: sẽ mô tả và thảo luận cụ thể một số vấn đề liên quan đến việc giải thích các kết quả có tính chất số học và dễ dàng phân tích thống kê, nhưng độ chính xác của chúng bị ảnh hưởng đáng kể bởi sự biến đổi của hóa chất và người điều hành.\u003C\u002Fjats:p>",{"EN":1066,"VI":1067},"Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems","Định lượng mRNA bằng phương pháp PCR Ngược Dòng Thời gian Thực: xu hướng và vấn 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phenotypic sex of many teleost fishes including flounders can be experimentally altered by treating embryos or larvae with varied temperatures or sex-steroid hormones. To analyse the sex determination mechanism, especially the role of cytochrome P450 aromatase (P450arom), an enzyme that catalyses the conversion of androgens to estrogens, in temperature-dependent gonadal sex differentiation in the Japanese flounder, we generated two populations of larvae, both having XX (genetic females) but each growing up to display all phenotypic females or males, by rearing the larvae at normal (18 degrees C) or high (27 degrees C) water temperatures from days 30 to 100 after hatching respectively. The larvae (XX) were produced artificially by mating normal females (XX) with gynogenetic diploid males (XX) which had been sex-reversed to phenotypic males by 17alpha-methyltestosterone. To study the role of P450arom in sex determination in the flounder, we first isolated a P450arom cDNA containing the complete open reading frame from the ovary. RT-PCR showed that P450arom mRNA was highly expressed in the ovary and spleen but weakly in the testis and brain. Semi-quantitative analyses of P450arom mRNA in gonads during sex differentiation showed that there was no difference in the levels of P450arom mRNA between the female and male groups when the gonad was sexually indifferent (day 50 after hatching). However, after the initiation of sex differentiation (day 60), the mRNA levels increased rapidly in the female group, whereas they decreased slightly in the male group. Similarly, estradiol-17beta levels rose remarkably in the female group, yet remained constant in the male group. These results suggest that induction of sex reversal of genetically female larvae to phenotypic males by rearing them at a high water temperature caused a suppression of P450arom gene expression. Furthermore, we suggest that the maintenance of P450arom mRNA at very low levels is a prerequisite for testicular differentiation, while the increased levels are indispensable for ovarian differentiation.\u003C\u002Fjats:p>","\u003Cjats:p>Giới tính kiểu hình của nhiều loài cá vây tia, bao gồm cả cá bơn, có thể được thay đổi một cách thực nghiệm bằng cách điều trị phôi hoặc ấu trùng dưới các nhiệt độ khác nhau hoặc hormone steroid giới tính. Để phân tích cơ chế xác định giới tính, đặc biệt là vai trò của cytochrome P450 aromatase (P450arom), một loại enzyme xúc tác chuyển đổi các androgen thành estrogen, trong sự khác biệt giới tính của tuyến sinh dục phụ thuộc vào nhiệt độ ở cá bơn Nhật Bản, chúng tôi đã tạo ra hai quần thể ấu trùng, cả hai đều có kiểu gen XX (cái di truyền) nhưng mỗi quần thể lớn lên để biểu hiện tất cả là cái kiểu hình hoặc đực kiểu hình, bằng cách nuôi dưỡng ấu trùng ở nhiệt độ nước bình thường (18 độ C) hoặc cao (27 độ C) từ ngày 30 đến 100 sau khi nở. Những ấu trùng (XX) được sản xuất nhân tạo bằng cách giao phối giữa những con cái bình thường (XX) với những con đực lưỡng bội sinh sản (XX) đã bị chuyển giới thành đực kiểu hình bằng 17alpha-methyltestosterone. Để nghiên cứu vai trò của P450arom trong xác định giới tính ở cá bơn, chúng tôi đã phân lập một cDNA P450arom chứa khung đọc mở hoàn chỉnh từ buồng trứng. RT-PCR cho thấy mRNA P450arom được biểu hiện cao ở buồng trứng và lách nhưng chỉ yếu ở tinh hoàn và não. Phân tích bán định lượng mRNA P450arom trong các tuyến sinh dục trong quá trình phân hóa giới tính cho thấy không có sự khác biệt về mức độ mRNA P450arom giữa nhóm cái và nhóm đực khi tuyến sinh dục còn không phân biệt giới tính (ngày 50 sau khi nở). Tuy nhiên, sau khi bắt đầu phân hóa giới tính (ngày 60), mức độ mRNA tăng nhanh chóng ở nhóm cái, trong khi chúng giảm nhẹ ở nhóm đực. Tương tự, mức estradiol-17beta tăng đáng kể ở nhóm cái, trong khi vẫn không thay đổi ở nhóm đực. Những kết quả này gợi ý rằng việc chuyển giới những ấu trùng cái di truyền thành đực kiểu hình bằng cách nuôi dưỡng chúng ở nhiệt độ nước cao đã gây ra sự ức chế biểu hiện gen P450arom. Hơn nữa, chúng tôi cho rằng việc duy trì mRNA P450arom ở mức rất thấp là điều kiện cần thiết cho sự phân hóa tinh hoàn, trong khi mức độ tăng là không thể thiếu cho sự phân hóa buồng trứng.\u003C\u002Fjats:p>",{"EN":1165,"VI":1166},"Suppression of P450 aromatase gene expression in sex-reversed males produced by rearing genetically female larvae at a high water temperature during a period of sex differentiation in the Japanese flounder (Paralichthys olivaceus)","Sự ức chế biểu hiện gen P450 aromatase ở những con đực chuyển giới được sản xuất bằng cách nuôi dưỡng ấu trùng cái di truyền ở nhiệt độ nước cao trong giai đoạn phân hóa giới tính ở cá bơn Nhật Bản (Paralichthys 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neuropeptide somatostatin (SRIF) is an important modulator of neurotransmission in the central nervous system and acts as a potent inhibitor of hormone and exocrine secretion. In addition, SRIF regulates cell proliferation in normal and tumorous tissues. The six somatostatin receptor subtypes (sst1, sst2A, sst2B, sst3, sst4, and sst5), which belong to the G protein-coupled receptor (GPCR) family, share a common molecular topology: a hydrophobic core of seven transmembrane-spanning α-helices, three intracellular loops, three extracellular loops, an amino-terminus outside the cell, and a carboxyl-terminus inside the cell. For most of the GPCRs, intracytosolic sequences, and more particularly the C-terminus, are believed to interact with proteins that are mandatory for either exporting neosynthesized receptor, anchoring receptor at the plasma membrane, internalization, recycling, or degradation after ligand binding. Accordingly, most of the SRIF receptors can traffic not only\u003Cjats:italic>in vitro\u003C\u002Fjats:italic>within different cell types but also\u003Cjats:italic>in vivo\u003C\u002Fjats:italic>. 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2010, Trends in endocrinology and metabolism: TEM, 21, 123, 10.1016\u002Fj.tem.2009.12.003",{"doi":1484},"10.1016\u002Fj.tem.2009.12.003",{"id":28,"text":1486,"url":28,"identifiers":1487},"2008, 157, 833",{},{"id":28,"text":1489,"url":28,"identifiers":1490},"Christenn, 2007, FEBS Letters, 581, 5173, 10.1016\u002Fj.febslet.2007.10.003",{"doi":1491},"10.1016\u002Fj.febslet.2007.10.003",{"id":28,"text":1493,"url":28,"identifiers":1494},"2001, 35, 1",{},{"id":28,"text":1496,"url":28,"identifiers":1497},"Csaba, 2001, Molecular and cellular neurosciences, 17, 646, 10.1006\u002Fmcne.2000.0958",{"doi":1498},"10.1006\u002Fmcne.2000.0958",{"id":28,"text":1500,"url":28,"identifiers":1501},"Csaba, 2002, The Journal of comparative neurology, 454, 192, 10.1002\u002Fcne.10430",{"doi":1502},"10.1002\u002Fcne.10430",{"id":28,"text":1504,"url":28,"identifiers":1505},"Csaba, 2003, Endocrinology, 144, 1564, 10.1210\u002Fen.2002-221090",{"doi":1506},"10.1210\u002Fen.2002-221090",{"id":28,"text":1508,"url":28,"identifiers":1509},"Csaba, 2004, The European journal of neuroscience, 19, 2531, 10.1111\u002Fj.0953-816X.2004.03361.x",{"doi":1510},"10.1111\u002Fj.0953-816X.2004.03361.x",{"id":28,"text":1512,"url":28,"identifiers":1513},"Csaba, 2005, Journal of neuropathology and experimental neurology, 64, 956, 10.1097\u002F01.jnen.0000186923.50215.50",{"doi":1514},"10.1097\u002F01.jnen.0000186923.50215.50",{"id":28,"text":1516,"url":28,"identifiers":1517},"Vazquez-Martinez, 2007, Traffic (Copenhagen, Denmark), 8, 820, 10.1111\u002Fj.1600-0854.2007.00580.x",{"doi":1518},"10.1111\u002Fj.1600-0854.2007.00580.x",{"id":28,"text":1520,"url":28,"identifiers":1521},"Defea, 2011, Cellular signalling, 23, 621, 10.1016\u002Fj.cellsig.2010.10.004",{"doi":1522},"10.1016\u002Fj.cellsig.2010.10.004",{"id":28,"text":1524,"url":28,"identifiers":1525},"Dournaud, 1998, Journal of Neuroscience, 18, 1056, 10.1523\u002FJNEUROSCI.18-03-01056.1998",{"doi":1526},"10.1523\u002FJNEUROSCI.18-03-01056.1998",{"id":28,"text":1528,"url":28,"identifiers":1529},"Duran-Prado, 2008, Molecular and cellular endocrinology, 286, 63, 10.1016\u002Fj.mce.2007.12.006",{"doi":1530},"10.1016\u002Fj.mce.2007.12.006",{"id":28,"text":1532,"url":28,"identifiers":1533},"Duvernay, 2005, Cellular signalling, 17, 1457, 10.1016\u002Fj.cellsig.2005.05.020",{"doi":1534},"10.1016\u002Fj.cellsig.2005.05.020",{"id":28,"text":1536,"url":28,"identifiers":1537},"2002, Molecular Endocrinology, 16, 2502, 10.1210\u002Fme.2002-0207",{"doi":1538},"10.1210\u002Fme.2002-0207",{"id":28,"text":1540,"url":28,"identifiers":1541},"2011, Journal of Biological Chemistry, 286, 13561, 10.1074\u002Fjbc.M110.215723",{"doi":1542},"10.1074\u002Fjbc.M110.215723",{"id":28,"text":1544,"url":28,"identifiers":1545},"2006, PNAS, 103, 16436, 10.1073\u002Fpnas.0607761103",{"doi":1546},"10.1073\u002Fpnas.0607761103",{"id":28,"text":1548,"url":28,"identifiers":1549},"Hipkin, 1997, Journal of Biological Chemistry, 272, 13869, 10.1074\u002Fjbc.272.21.13869",{"doi":1550},"10.1074\u002Fjbc.272.21.13869",{"id":28,"text":1552,"url":28,"identifiers":1553},"Hipkin, 2000, Journal of Biological Chemistry, 275, 5591, 10.1074\u002Fjbc.275.8.5591",{"doi":1554},"10.1074\u002Fjbc.275.8.5591",{"id":28,"text":1556,"url":28,"identifiers":1557},"Hofland, 1999, Journal of Clinical Endocrinology & Metabolism, 84, 775, 10.1210\u002Fjc.84.2.775",{"doi":1558},"10.1210\u002Fjc.84.2.775",{"id":28,"text":1560,"url":28,"identifiers":1561},"Hukovic, 1998, Journal of Biological Chemistry, 273, 21416, 10.1074\u002Fjbc.273.33.21416",{"doi":1562},"10.1074\u002Fjbc.273.33.21416",{"id":28,"text":1564,"url":28,"identifiers":1565},"Jacobs, 2008, Molecular and cellular endocrinology, 286, 58, 10.1016\u002Fj.mce.2007.10.005",{"doi":1566},"10.1016\u002Fj.mce.2007.10.005",{"id":28,"text":1568,"url":28,"identifiers":1569},"Janson, 2000, Journal of Nuclear Medicine, 41, 1514",{},{"id":28,"text":1571,"url":28,"identifiers":1572},"2011, Molecular Endocrinology, 25, 1040, 10.1210\u002Fme.2010-0398",{"doi":1573},"10.1210\u002Fme.2010-0398",{"id":28,"text":1575,"url":28,"identifiers":1576},"Kreuzer, 2001, Journal of neuroendocrinology, 13, 279, 10.1046\u002Fj.1365-2826.2001.00630.x",{"doi":1577},"10.1046\u002Fj.1365-2826.2001.00630.x",{"id":28,"text":1579,"url":28,"identifiers":1580},"Kulaksiz, 2002, Gut, 50, 52, 10.1136\u002Fgut.50.1.52",{"doi":1581},"10.1136\u002Fgut.50.1.52",{"id":28,"text":1583,"url":28,"identifiers":1584},"Lelouvier, 2008, Journal of Neuroscience, 28, 4336, 10.1523\u002FJNEUROSCI.4379-07.2008",{"doi":1585},"10.1523\u002FJNEUROSCI.4379-07.2008",{"id":28,"text":1587,"url":28,"identifiers":1588},"2009, Journal of Clinical Endocrinology & Metabolism, 94, 654, 10.1210\u002Fjc.2008-1919",{"doi":1589},"10.1210\u002Fjc.2008-1919",{"id":28,"text":1591,"url":28,"identifiers":1592},"Le Verche, 2009, 4, e5509, 10.1371\u002Fjournal.pone.0005509",{"doi":1593},"10.1371\u002Fjournal.pone.0005509",{"id":28,"text":1595,"url":28,"identifiers":1596},"Liew, 2009, FEBS Letters, 583, 49, 10.1016\u002Fj.febslet.2008.11.048",{"doi":1597},"10.1016\u002Fj.febslet.2008.11.048",{"id":28,"text":1599,"url":28,"identifiers":1600},"2001, Journal of Biological Chemistry, 276, 3709, 10.1074\u002Fjbc.M008873200",{"doi":1601},"10.1074\u002Fjbc.M008873200",{"id":28,"text":1603,"url":28,"identifiers":1604},"Liu, 2003, Journal of Clinical Endocrinology & Metabolism, 88, 6073, 10.1210\u002Fjc.2003-030986",{"doi":1605},"10.1210\u002Fjc.2003-030986",{"id":28,"text":1607,"url":28,"identifiers":1608},"2005, Molecular Pharmacology, 68, 90, 10.1124\u002Fmol.105.011767",{"doi":1609},"10.1124\u002Fmol.105.011767",{"id":28,"text":1611,"url":28,"identifiers":1612},"2008, Molecular 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10.1210\u002Fer.2002-0007",{"doi":1637},"10.1210\u002Fer.2002-0007",{"id":28,"text":1639,"url":28,"identifiers":1640},"Reubi, 1987, Cancer Research, 47, 551",{},{"id":28,"text":1642,"url":28,"identifiers":1643},"Reubi, 1990, The Journal of steroid biochemistry and molecular biology, 37, 1073, 10.1016\u002F0960-0760(90)90468-Z",{"doi":1644},"10.1016\u002F0960-0760(90)90468-Z",{"id":28,"text":1646,"url":28,"identifiers":1647},"1991, Acta oncol  gica, 30, 463",{},{"id":28,"text":1649,"url":28,"identifiers":1650},"Reubi, 1992, The Journal of steroid biochemistry and molecular biology, 43, 27, 10.1016\u002F0960-0760(92)90184-K",{"doi":1651},"10.1016\u002F0960-0760(92)90184-K",{"id":28,"text":1653,"url":28,"identifiers":1654},"Reubi, 1996, Metabolism: clinical and experimental, 45, 39, 10.1016\u002FS0026-0495(96)90077-3",{"doi":1655},"10.1016\u002FS0026-0495(96)90077-3",{"id":28,"text":1657,"url":28,"identifiers":1658},"Reubi, 1998, American Journal Of Pathology, 153, 233, 10.1016\u002FS0002-9440(10)65564-2",{"doi":1659},"10.1016\u002FS0002-9440(10)65564-2",{"id":28,"text":1661,"url":28,"identifiers":1662},"Reubi, 2000, Journal of Clinical Endocrinology & Metabolism, 85, 3882, 10.1210\u002Fjc.85.10.3882",{"doi":1663},"10.1210\u002Fjc.85.10.3882",{"id":28,"text":1665,"url":28,"identifiers":1666},"2010, Journal of Clinical Endocrinology & Metabolism, 95, 2343, 10.1210\u002Fjc.2009-2487",{"doi":1667},"10.1210\u002Fjc.2009-2487",{"id":28,"text":1669,"url":28,"identifiers":1670},"Roth, 1997, Journal of Biological Chemistry, 272, 23769, 10.1074\u002Fjbc.272.38.23769",{"doi":1671},"10.1074\u002Fjbc.272.38.23769",{"id":28,"text":1673,"url":28,"identifiers":1674},"Roth, 1997, DNA and cell biology, 16, 111, 10.1089\u002Fdna.1997.16.111",{"doi":1675},"10.1089\u002Fdna.1997.16.111",{"id":28,"text":1677,"url":28,"identifiers":1678},"2004, Journal of Biological Chemistry, 279, 8029, 10.1074\u002Fjbc.M310792200",{"doi":1679},"10.1074\u002Fjbc.M310792200",{"id":28,"text":1681,"url":28,"identifiers":1682},"Schreff, 2000, Journal of Neuroscience, 20, 3785, 10.1523\u002FJNEUROSCI.20-10-03785.2000",{"doi":1683},"10.1523\u002FJNEUROSCI.20-10-03785.2000",{"id":28,"text":1685,"url":28,"identifiers":1686},"Schulz, 2000, Journal of physiology, Paris, 94, 259, 10.1016\u002FS0928-4257(00)00212-6",{"doi":1687},"10.1016\u002FS0928-4257(00)00212-6",{"id":28,"text":1689,"url":28,"identifiers":1690},"Schulz, 2000, Clinical Cancer Research, 6, 1865",{},{"id":28,"text":1692,"url":28,"identifiers":1693},"Schwarzler, 2000, Journal of Biological Chemistry, 275, 9557, 10.1074\u002Fjbc.275.13.9557",{"doi":1694},"10.1074\u002Fjbc.275.13.9557",{"id":28,"text":1696,"url":28,"identifiers":1697},"Sheng, 2001, Annual review of neuroscience, 24, 1, 10.1146\u002Fannurev.neuro.24.1.1",{"doi":1698},"10.1146\u002Fannurev.neuro.24.1.1",{"id":28,"text":1700,"url":28,"identifiers":1701},"Stroh, 2000, Endocrinology, 141, 354, 10.1210\u002Fen.141.1.354",{"doi":1702},"10.1210\u002Fen.141.1.354",{"id":28,"text":1704,"url":28,"identifiers":1705},"Stroh, 2009, Journal of Neuroscience, 29, 8198, 10.1523\u002FJNEUROSCI.0336-09.2009",{"doi":1706},"10.1523\u002FJNEUROSCI.0336-09.2009",{"id":28,"text":1708,"url":28,"identifiers":1709},"Stumm, 2004, Journal of Neuroscience, 24, 11404, 10.1523\u002FJNEUROSCI.3834-04.2004",{"doi":1710},"10.1523\u002FJNEUROSCI.3834-04.2004",{"id":28,"text":1712,"url":28,"identifiers":1713},"Tulipano, 2007, European Journal of Endocrinology, 156, S3, 10.1530\u002Feje.1.02354",{"doi":1714},"10.1530\u002Feje.1.02354",{"id":28,"text":1716,"url":28,"identifiers":1717},"2004, Journal of Biological Chemistry, 279, 21374, 10.1074\u002Fjbc.M313522200",{"doi":1718},"10.1074\u002Fjbc.M313522200",{"id":28,"text":1720,"url":28,"identifiers":1721},"Weckbecker, 2003, Nature reviews. Drug discovery, 2, 999, 10.1038\u002Fnrd1255",{"doi":1722},"10.1038\u002Fnrd1255",{"id":28,"text":1724,"url":28,"identifiers":1725},"2005, Journal of Biological Chemistry, 280, 32419, 10.1074\u002Fjbc.M507198200",{"doi":1726},"10.1074\u002Fjbc.M507198200",{"id":28,"text":1728,"url":28,"identifiers":1729},"Zitzer, 1999, Journal of Biological Chemistry, 274, 32997, 10.1074\u002Fjbc.274.46.32997",{"doi":1730},"10.1074\u002Fjbc.274.46.32997",{"id":28,"text":1732,"url":28,"identifiers":1733},"Zitzer, 1999, Journal of Biological Chemistry, 274, 18153, 10.1074\u002Fjbc.274.26.18153",{"doi":1734},"10.1074\u002Fjbc.274.26.18153",{"id":1736,"createTime":1737,"updateTime":1738,"relativeEntities":1739,"slug":1740,"properties":1741,"entityType":964,"verifyStatus":884,"verifyTime":1737,"verifyNote":1757,"languages":1758,"translateLanguages":1759,"viewCount":32,"primaryUrl":1760,"fullTextUrl":28,"authors":1761,"publicationType":989,"publisherRelationship":1801,"citationCount":614,"citationInfo":1845,"publishDate":1848,"publishYear":1846,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":1849,"openAccess":28,"references":1850,"isForceReanalyzing":1048},"4b9bded3-48ae-4392-8cba-16fbe26fab0f","2024-09-03T03:08:43.517+00:00","2025-02-08T04:57:58.981+00:00",[],"Peroxisome-proliferator-activated-receptor-gamma-from-adipogenesis-to-carcinogenesis",{"mag":1742,"keywords":1744,"openalex":1745,"abstract":1747,"title":1750,"pm":1753,"doi":1755},{"VOID":1743},"2158609897",{"VI":1158},{"VOID":1746},"W2158609897",{"EN":1748,"VI":1749},"\u003Cjats:p>Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for synthetic compounds inducing peroxisome proliferation. PPAR-gamma, the best characterized of the PPARs, plays a crucial role in adipogenesis and insulin sensitization. Furthermore, PPAR-gamma has been reported to affect cell proliferation\u002Fdifferentiation pathways in various malignancies. We discuss in the present review recent advances in the understanding of the function of PPAR-gamma in both cell proliferation and adipocyte differentiation.\u003C\u002Fjats:p>","\u003Cjats:p>Các thụ thể kích hoạt peroxisome proliferator (PPARs) là các thụ thể hormon hạt nhân, được miêu tả lần đầu tiên như là các mục tiêu phân tử cho các hợp chất tổng hợp gây ra sự gia tăng peroxisome. PPAR-gamma, thụ thể được nghiên cứu kĩ lưỡng nhất trong số các PPARs, đóng vai trò quan trọng trong quá trình sinh adipose và tăng cường độ nhạy insulin. Hơn nữa, PPAR-gamma đã được báo cáo là có ảnh hưởng đến các con đường phân chia\u002Ftuyến hóa tế bào trong nhiều loại ác tính khác nhau. Trong bài viết này, chúng tôi sẽ thảo luận về các tiến bộ gần đây trong việc hiểu biết chức năng của PPAR-gamma trong cả quá trình phân chia tế bào và phân hóa tế bào mỡ.\u003C\u002Fjats:p>",{"EN":1751,"VI":1752},"Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis","Thụ thể kích hoạt peroxisome proliferator-gamma: từ sinh adipose đến ung thư sinh",{"VOID":1754},"11463572",{"VOID":1756},"10.1677\u002Fjme.0.0270001","Author affiliation is blank",[31],[30],"https:\u002F\u002Fjme.bioscientifica.com\u002Fview\u002Fjournals\u002Fjme\u002F27\u002F1\u002F1.xml",[1762,1773,1782],{"id":1763,"sortIndex":32,"researcher":28,"roles":1764,"affiliations":1765,"properties":1766,"displayName":1770,"givenName":28,"familyName":28},"8ba3db89-b008-4dbf-9784-af602721ff63",[],[],{"orcid":1767,"title":1769,"openalex":1771},{"VOID":1768},"https:\u002F\u002Forcid.org\u002F0000-0002-1283-9503",{"EN":1770},"Lluís Fajas",{"VOID":1772},"A5009899895",{"id":1774,"sortIndex":40,"researcher":28,"roles":1775,"affiliations":1776,"properties":1777,"displayName":1779,"givenName":28,"familyName":28},"b7ced426-2be0-4bb4-936d-ce1cb656f7bd",[],[],{"title":1778,"openalex":1780},{"EN":1779},"M B Debril",{"VOID":1781},"A5068698974",{"id":1783,"sortIndex":123,"researcher":28,"roles":1784,"affiliations":1785,"properties":1794,"displayName":1798,"givenName":28,"familyName":28},"0dc24735-ace1-483d-8899-2e8a5fe9a2e0",[],[1786],{"id":1787,"sortIndex":32,"affiliation":1788,"properties":28},"8ee6c33f-44a4-4720-ab40-c0bb9da4371c",{"id":1787,"createTime":28,"updateTime":28,"relativeEntities":1789,"slug":28,"properties":1790,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1793,"statistic":28},[],{"title":1791},{"EN":1792},"Institut de Génétique et de Biologie Moléculaire et Cellulaire",[],{"orcid":1795,"title":1797,"openalex":1799},{"VOID":1796},"https:\u002F\u002Forcid.org\u002F0000-0002-5065-5393",{"EN":1798},"Johan Auwerx",{"VOID":1800},"A5003154600",{"url":28,"publisher":1802,"properties":1839},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1803,"slug":872,"properties":1804,"entityType":25,"verifyStatus":884,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1809,"manageAffiliations":1818,"indexDatabases":1824,"url":936,"thumbnailPath":28,"statistic":28,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"country":1805,"eissn":1806,"issn":1807,"title":1808},{"VOID":875},{"VOID":877},{"VOID":879},{"EN":881},[1810,1814],{"id":887,"createTime":28,"updateTime":28,"relativeEntities":1811,"label":1812,"description":1813,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},{"id":893,"createTime":28,"updateTime":28,"relativeEntities":1815,"label":1816,"description":1817,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":896},{},[1819],{"id":900,"createTime":28,"updateTime":28,"relativeEntities":1820,"slug":28,"properties":1821,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1823,"statistic":28},[],{"title":1822},{"EN":904},[],[1825,1832],{"id":908,"indexDatabase":1826,"url":914,"indexYears":915,"academicFieldIds":1831,"indexDatabaseRanking":919},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":1827,"label":1828,"description":1829,"key":781,"publicationTags":1830,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[917,918],{"id":921,"indexDatabase":1833,"url":933,"indexYears":28,"academicFieldIds":1838,"indexDatabaseRanking":28},{"id":923,"createTime":28,"updateTime":28,"relativeEntities":1834,"label":1835,"description":1836,"key":930,"publicationTags":1837,"standard":28},[],{"EN":926,"VI":926},{"EN":928,"VI":929},[932,813],[935],{"issue":1840,"pages":1841,"volume":1843},{"VOID":1132},{"VOID":1842},"1-9",{"VOID":1844},"27",{"total":614,"publishYear":1846,"statisticByYear":1847},2001,{"2012":205,"2013":205,"2014":48,"2015":45,"2016":123,"2017":42,"2018":45,"2019":45,"2020":46,"2021":45,"2022":123,"2023":46,"2024":40},"2001-08-01",[932,919],[],{"id":1852,"createTime":1853,"updateTime":1854,"relativeEntities":1855,"slug":1856,"properties":1857,"entityType":964,"verifyStatus":884,"verifyTime":1874,"verifyNote":1757,"languages":1875,"translateLanguages":1876,"viewCount":32,"primaryUrl":1877,"fullTextUrl":28,"authors":1878,"publicationType":989,"publisherRelationship":1905,"citationCount":1949,"citationInfo":1950,"publishDate":1952,"publishYear":1316,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":1953,"openAccess":28,"references":1954,"isForceReanalyzing":1048},"1ee73560-8914-41dd-892e-5c8d02970f6e","2024-09-13T02:16:33.978+00:00","2025-02-08T04:58:58.422+00:00",[],"Peroxisome-proliferator-activated-receptor-alpha-role-in-rodent-liver-cancer-and-species-differences",{"mag":1858,"keywords":1860,"openalex":1862,"abstract":1864,"title":1867,"pm":1870,"doi":1872},{"VOID":1859},"2065624367",{"VI":1861},"Peroxisome proliferators, PPARalpha, ung thư gan, động vật gặm nhấm, sự khác biệt giữa các loài",{"VOID":1863},"W2065624367",{"EN":1865,"VI":1866},"\u003Cjats:p>Peroxisome proliferators (PPs) are chemicals of industrial and pharmaceutical importance that elicit liver carcinogenesis by a non-genotoxic mechanism. One of the intriguing properties of PPs is that the pleiotropic effects of these compounds (including increased DNA synthesis and peroxisome proliferation) are seen in rats and mice only, but not humans. It is important to determine the risks to humans of environmental and therapeutic exposure to these compounds by understanding the mechanisms of non-genotoxic hepatocarcinogenesis in rodents. To understand this apparent lack of human susceptibility, attention has focused on the peroxisome proliferator-activated receptor alpha (PPARalpha), which appears to mediate the effects of PPs in rodents. It is also known to mediate the hypolipidaemic effects that fibrate drugs exert on humans with elevated plasma cholesterol and triglyceride levels. Human PPARalphas share many functional characteristics with the rodent receptors, in that they can be transcriptionally activated by PPs and regulate specific gene expression. However, one key difference is that PPARalpha is less abundant in human than in rodent liver, which has led to the suggestion that species differences result from quantitative differences in gene expression. In this review we describe the effects of PPs and what is known of the molecular mechanisms of action and species differences with respect to rodents and man. Attention will be given to differences in the amounts of PPARalpha between species as well as the 'qualitative' aspects of PPARalpha-mediated gene regulation which might also explain the activation of some genes and not of others in human liver by PPs.\u003C\u002Fjats:p>","\u003Cjats:p>Các chất kích thích peroxisome (PPs) là hóa chất có tầm quan trọng trong công nghiệp và dược phẩm, gây ra ung thư gan qua cơ chế không di truyền. Một trong những đặc tính thú vị của PPs là các tác động đa dạng của những hợp chất này (bao gồm cả việc tăng tổng hợp DNA và sự tăng sinh peroxisome) chỉ được quan sát ở chuột và chuột lang, mà không có ở người. Việc hiểu rõ các nguy cơ đối với con người từ việc tiếp xúc với các hợp chất này trong môi trường và điều trị rất quan trọng, và điều này phụ thuộc vào việc hiểu các cơ chế ung thư gan không di truyền ở động vật gặm nhấm. Để hiểu sự thiếu nhạy cảm rõ rệt này ở con người, chú ý đã được hướng tới thụ thể được hoạt hóa bởi peroxisome proliferator alpha (PPARalpha), thụ thể này dường như trung gian cho các tác động của PPs ở gặm nhấm. Nó cũng được biết đến để trung gian cho các tác động hạ lipid máu mà các thuốc fibrate gây ra ở người có mức cholesterol và triglyceride huyết tương cao. Các thụ thể PPARalpha ở người có nhiều đặc điểm chức năng giống với các thụ thể ở động vật gặm nhấm, ở chỗ chúng có thể được kích hoạt phiên mã bởi PPs và điều chỉnh sự biểu hiện của một số gen nhất định. Tuy nhiên, một sự khác biệt chính là PPARalpha ít phong phú hơn ở gan người so với gan gặm nhấm, điều này đã dẫn đến gợi ý rằng sự khác biệt giữa các loài xuất phát từ sự khác biệt định lượng trong sự biểu hiện gene. Trong bài đánh giá này, chúng tôi mô tả các tác động của PPs và những gì được biết về các cơ chế tác động phân tử cũng như sự khác biệt giữa các loài liên quan đến gặm nhấm và con người. Sẽ chú ý đến sự khác biệt về lượng PPARalpha giữa các loài cũng như các khía cạnh 'chất lượng' trong việc điều chỉnh gene do PPARalpha trung gian, điều này cũng có thể giải thích việc kích hoạt một số gen và không kích hoạt những gen khác trong gan người do PPs gây ra.\u003C\u002Fjats:p>",{"EN":1868,"VI":1869},"Peroxisome proliferator-activated receptor alpha: role in rodent liver cancer and species differences","Thụ thể được hoạt hóa bởi peroxisome proliferator alpha: vai trò trong ung thư gan ở gặm nhấm và sự khác biệt giữa các loài",{"VOID":1871},"9924174",{"VOID":1873},"10.1677\u002Fjme.0.0220001","2024-09-13T02:16:33.977+00:00",[31],[30],"https:\u002F\u002Fjme.bioscientifica.com\u002Fview\u002Fjournals\u002Fjme\u002F22\u002F1\u002F1.xml",[1879,1896],{"id":1880,"sortIndex":32,"researcher":28,"roles":1881,"affiliations":1882,"properties":1891,"displayName":1893,"givenName":28,"familyName":28},"f0b96ea1-4b97-4109-b08a-91d1155ab736",[],[1883],{"id":1884,"sortIndex":32,"affiliation":1885,"properties":28},"ddf59852-c793-4c6e-be50-16d336592ae5",{"id":1884,"createTime":28,"updateTime":28,"relativeEntities":1886,"slug":28,"properties":1887,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1890,"statistic":28},[],{"title":1888},{"VI":1889},"Zeneca Central Toxicology Laboratory, Alderley Park, Macclesfield, SK10 4TJ, UK",[],{"title":1892,"openalex":1894},{"EN":1893},"Peter R. Holden",{"VOID":1895},"A5022177451",{"id":1897,"sortIndex":40,"researcher":28,"roles":1898,"affiliations":1899,"properties":1900,"displayName":1902,"givenName":28,"familyName":28},"32f87f32-f83d-4c80-a24f-d848e8c390b7",[],[],{"title":1901,"openalex":1903},{"EN":1902},"J D Tugwood",{"VOID":1904},"A5071768701",{"url":28,"publisher":1906,"properties":1943},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1907,"slug":872,"properties":1908,"entityType":25,"verifyStatus":884,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1913,"manageAffiliations":1922,"indexDatabases":1928,"url":936,"thumbnailPath":28,"statistic":28,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"country":1909,"eissn":1910,"issn":1911,"title":1912},{"VOID":875},{"VOID":877},{"VOID":879},{"EN":881},[1914,1918],{"id":887,"createTime":28,"updateTime":28,"relativeEntities":1915,"label":1916,"description":1917,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},{"id":893,"createTime":28,"updateTime":28,"relativeEntities":1919,"label":1920,"description":1921,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":896},{},[1923],{"id":900,"createTime":28,"updateTime":28,"relativeEntities":1924,"slug":28,"properties":1925,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1927,"statistic":28},[],{"title":1926},{"EN":904},[],[1929,1936],{"id":908,"indexDatabase":1930,"url":914,"indexYears":915,"academicFieldIds":1935,"indexDatabaseRanking":919},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":1931,"label":1932,"description":1933,"key":781,"publicationTags":1934,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[917,918],{"id":921,"indexDatabase":1937,"url":933,"indexYears":28,"academicFieldIds":1942,"indexDatabaseRanking":28},{"id":923,"createTime":28,"updateTime":28,"relativeEntities":1938,"label":1939,"description":1940,"key":930,"publicationTags":1941,"standard":28},[],{"EN":926,"VI":926},{"EN":928,"VI":929},[932,813],[935],{"issue":1944,"pages":1945,"volume":1947},{"VOID":1132},{"VOID":1946},"1-8",{"VOID":1948},"22",198,{"total":1949,"publishYear":1316,"statisticByYear":1951},{"2012":323,"2013":145,"2014":48,"2015":46,"2016":42,"2017":49,"2018":145,"2019":49,"2020":48,"2021":45,"2022":45,"2023":46,"2024":40},"1999-02-01",[932,919],[],{"id":1956,"createTime":1957,"updateTime":1958,"relativeEntities":1959,"slug":1960,"properties":1961,"entityType":964,"verifyStatus":884,"verifyTime":1957,"verifyNote":1757,"languages":1977,"translateLanguages":1978,"viewCount":32,"primaryUrl":1979,"fullTextUrl":28,"authors":1980,"publicationType":989,"publisherRelationship":2036,"citationCount":570,"citationInfo":2080,"publishDate":2083,"publishYear":2081,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":2084,"openAccess":28,"references":2085,"isForceReanalyzing":1048},"939736e0-ce70-4d50-9c59-56f22dcaa8f0","2024-09-24T03:18:37.330+00:00","2025-02-08T04:59:58.165+00:00",[],"Inhibition-of-proliferation-of-prostate-cancer-cells-by-a-19-nor-hexafluoride-vitamin-D3-analogue-involves-the-induction-of-p21waf1-p27kip1-and-E-cadherin",{"mag":1962,"keywords":1964,"openalex":1965,"abstract":1967,"title":1970,"pm":1973,"doi":1975},{"VOID":1963},"2071429904",{"VI":1158},{"VOID":1966},"W2071429904",{"EN":1968,"VI":1969},"\u003Cjats:title>ABSTRACT\u003C\u002Fjats:title>\n\u003Cjats:p>We have synthesized and studied the ability of a series of seven novel 1α,25(OH)\u003Cjats:sub>2\u003C\u002Fjats:sub> vitamin D\u003Cjats:sub>3\u003C\u002Fjats:sub> analogues to inhibit clonal growth of prostate cancer cells (LNCaP, PC-3 and DU-145). Addition of double and triple bonds to the C\u002FD ring (C-16) and side chain (C-22 and C-23) as well as lengthening of the side chain were important for enhanced activity against LNCaP and PC-3. Reorientation of the side chain in the 20-epi configuration resulted in analogues that were extremely potent only against LNCaP (ED\u003Cjats:sub>50\u003C\u002Fjats:sub> ≈ 5 × 10\u003Cjats:sup>−11\u003C\u002Fjats:sup> \u003Cjats:sc>m\u003C\u002Fjats:sc>). Compounds with six fluorines on the end of the side chain were very active against both PC-3 and LNCaP (ED\u003Cjats:sub>50\u003C\u002Fjats:sub> ≈ 2 × 10\u003Cjats:sup>−8\u003C\u002Fjats:sup> \u003Cjats:sc>m\u003C\u002Fjats:sc>). DU-145 cells were relatively resistant to compounds with all of these modifications, but removal of C-19 (e.g. 1,25(OH)\u003Cjats:sub>2\u003C\u002Fjats:sub>-16-ene-23-yne-26,27-F\u003Cjats:sub>6\u003C\u002Fjats:sub>-19-nor-D\u003Cjats:sub>3\u003C\u002Fjats:sub>) resulted in an analogue that was inhibitory against all three prostate cell lines. Further analysis showed that pulse exposure (3 days, 10\u003Cjats:sup>−7\u003C\u002Fjats:sup> \u003Cjats:sc>m\u003C\u002Fjats:sc>) to this analogue was enough to inhibit clonal growth of PC-3 cells by 50%. The same exposure also induced cell cycle arrest of all three cell lines, accompanied by upregulated protein expression of the cyclin-dependent kinase inhibitor (CDKI) known as p21\u003Cjats:sup>\u003Cjats:italic>waf1\u003C\u002Fjats:italic>\u003C\u002Fjats:sup> in all three cell lines, and the CDKI known as p27\u003Cjats:sup>\u003Cjats:italic>kip1\u003C\u002Fjats:italic>\u003C\u002Fjats:sup> in LNCaP cells. Associated with upregulation of these CDKIs, partial differentiation occurred as measured by increased expression of both prostate-specific antigen by LNCaP cells and E-cadherin, a cell adhesion protein that may act as a putative tumour suppressor (LNCaP and PC-3 cells). In summary, this is the first report of a potent series of 19-nor-vitamin D\u003Cjats:sub>3\u003C\u002Fjats:sub> analogues with the ability to inhibit proliferation of LNCaP, PC-3 and DU-145 prostate cancer cell lines. These compounds may mediate their potent anti-proliferative activities through a cell cycle arrest pathway.\u003C\u002Fjats:p>","\u003Cjats:title>TÓM TẮT\u003C\u002Fjats:title>\n\u003Cjats:p>Chúng tôi đã tổng hợp và nghiên cứu khả năng của một loạt bảy dẫn xuất mới 1α,25(OH)\u003Cjats:sub>2\u003C\u002Fjats:sub> vitamin D\u003Cjats:sub>3\u003C\u002Fjats:sub> trong việc ức chế sự phát triển nhân giống của các tế bào ung thư tuyến tiền liệt (LNCaP, PC-3 và DU-145). Việc thêm liên kết đôi và ba vào vòng C\u002FD (C-16) và chuỗi bên (C-22 và C-23) cũng như việc kéo dài chuỗi bên rất quan trọng cho hoạt tính tăng cường đối với LNCaP và PC-3. Sự định hướng lại của chuỗi bên trong cấu hình 20-epi dẫn đến các dẫn xuất cực kỳ mạnh chỉ chống lại LNCaP (ED\u003Cjats:sub>50\u003C\u002Fjats:sub> ≈ 5 × 10\u003Cjats:sup>−11\u003C\u002Fjats:sup> \u003Cjats:sc>m\u003C\u002Fjats:sc>). Các hợp chất với sáu fluor ở đầu chuỗi bên có hoạt tính rất mạnh chống lại cả PC-3 và LNCaP (ED\u003Cjats:sub>50\u003C\u002Fjats:sub> ≈ 2 × 10\u003Cjats:sup>−8\u003C\u002Fjats:sup> \u003Cjats:sc>m\u003C\u002Fjats:sc>). Các tế bào DU-145 tương đối kháng với các hợp chất có tất cả các sửa đổi này, nhưng khi loại bỏ C-19 (ví dụ: 1,25(OH)\u003Cjats:sub>2\u003C\u002Fjats:sub>-16-ene-23-yne-26,27-F\u003Cjats:sub>6\u003C\u002Fjats:sub>-19-nor-D\u003Cjats:sub>3\u003C\u002Fjats:sub>) dẫn đến một dẫn xuất có khả năng ức chế tất cả ba dòng tế bào tuyến tiền liệt. Phân tích thêm cho thấy rằng việc phơi nhiễm tạm thời (3 ngày, 10\u003Cjats:sup>−7\u003C\u002Fjats:sup> \u003Cjats:sc>m\u003C\u002Fjats:sc>) với dẫn xuất này đã đủ để ức chế sự phát triển nhân giống của tế bào PC-3 bằng 50%. Phơi nhiễm tương tự cũng gây ra việc kìm hãm chu kỳ tế bào của tất cả ba dòng tế bào, đi kèm với sự tăng cường biểu hiện protein của chất ức chế kinase phụ thuộc cyclin (CDKI) được biết đến với tên gọi p21\u003Cjats:sup>\u003Cjats:italic>waf1\u003C\u002Fjats:italic>\u003C\u002Fjats:sup> trong cả ba dòng tế bào, và CDKI được biết đến với tên gọi p27\u003Cjats:sup>\u003Cjats:italic>kip1\u003C\u002Fjats:italic>\u003C\u002Fjats:sup> trong các tế bào LNCaP. Liên quan đến sự tăng cường các CDKI này, hiện tượng phân hóa một phần xảy ra, được đo bằng việc tăng cường biểu hiện của cả kháng nguyên cụ thể của tuyến tiền liệt ở tế bào LNCaP và E-cadherin, một protein liên kết tế bào có thể hoạt động như một chất ức chế khối u dự kiến (tế bào LNCaP và PC-3). Tóm tắt, đây là báo cáo đầu tiên về một loạt các dẫn xuất 19-nor-vitamin D\u003Cjats:sub>3\u003C\u002Fjats:sub> có khả năng ức chế sự tăng trưởng của các dòng tế bào ung thư tuyến tiền liệt LNCaP, PC-3 và DU-145. Các hợp chất này có thể làm trung gian cho các hoạt động ức chế tăng trưởng mạnh mẽ của chúng thông qua một con đường kìm hãm chu kỳ tế bào.\u003C\u002Fjats:p>",{"EN":1971,"VI":1972},"Inhibition of proliferation of prostate cancer cells by a 19-nor-hexafluoride vitamin D3 analogue involves the induction of p21waf1, p27kip1 and E-cadherin","Sự ức chế sự phát triển của các tế bào ung thư tuyến tiền liệt bởi một dẫn xuất vitamin D3 có 19-nor-hexafluoride liên quan đến sự kích thích p21waf1, p27kip1 và E-cadherin",{"VOID":1974},"9278857",{"VOID":1976},"10.1677\u002Fjme.0.0190015",[31],[30],"https:\u002F\u002Fjme.bioscientifica.com\u002Fview\u002Fjournals\u002Fjme\u002F19\u002F1\u002Fjme_19_1_002.xml",[1981,2000,2009,2018,2027],{"id":1982,"sortIndex":32,"researcher":28,"roles":1983,"affiliations":1984,"properties":1993,"displayName":1997,"givenName":28,"familyName":28},"92a89a2a-b48d-4a89-bda8-afc89c73158a",[],[1985],{"id":1986,"sortIndex":32,"affiliation":1987,"properties":28},"81d2ebcb-dbff-452a-853b-35dbd1698ab7",{"id":1986,"createTime":28,"updateTime":28,"relativeEntities":1988,"slug":28,"properties":1989,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1992,"statistic":28},[],{"title":1990},{"EN":1991},"Division of Hematology\u002FOncology, Cedars-Sinai Medical Center\u002FUCLA School of Medicine 90048, USA.",[],{"orcid":1994,"title":1996,"openalex":1998},{"VOID":1995},"https:\u002F\u002Forcid.org\u002F0000-0002-3355-0928",{"EN":1997},"Moray J. Campbell",{"VOID":1999},"A5060760341",{"id":2001,"sortIndex":40,"researcher":28,"roles":2002,"affiliations":2003,"properties":2004,"displayName":2006,"givenName":28,"familyName":28},"0d75b1ad-b3c6-49c5-a515-ca62e0866f11",[],[],{"title":2005,"openalex":2007},{"EN":2006},"Elena Elstner",{"VOID":2008},"A5073043527",{"id":2010,"sortIndex":123,"researcher":28,"roles":2011,"affiliations":2012,"properties":2013,"displayName":2015,"givenName":28,"familyName":28},"c0680c28-4abf-4156-8f95-6fde798f8db0",[],[],{"title":2014,"openalex":2016},{"EN":2015},"Stuart Holden",{"VOID":2017},"A5076964171",{"id":2019,"sortIndex":42,"researcher":28,"roles":2020,"affiliations":2021,"properties":2022,"displayName":2024,"givenName":28,"familyName":28},"3fc38624-cebc-4778-9961-9ce83e6a00de",[],[],{"title":2023,"openalex":2025},{"EN":2024},"Milan R. Uskoković",{"VOID":2026},"A5034479183",{"id":2028,"sortIndex":45,"researcher":28,"roles":2029,"affiliations":2030,"properties":2031,"displayName":2033,"givenName":28,"familyName":28},"bbf9e4cb-45f0-4e39-8b07-838dfb8a40e0",[],[],{"title":2032,"openalex":2034},{"EN":2033},"H P Koeffler",{"VOID":2035},"A5044012656",{"url":28,"publisher":2037,"properties":2074},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":2038,"slug":872,"properties":2039,"entityType":25,"verifyStatus":884,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":2044,"manageAffiliations":2053,"indexDatabases":2059,"url":936,"thumbnailPath":28,"statistic":28,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"country":2040,"eissn":2041,"issn":2042,"title":2043},{"VOID":875},{"VOID":877},{"VOID":879},{"EN":881},[2045,2049],{"id":887,"createTime":28,"updateTime":28,"relativeEntities":2046,"label":2047,"description":2048,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},{"id":893,"createTime":28,"updateTime":28,"relativeEntities":2050,"label":2051,"description":2052,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":896},{},[2054],{"id":900,"createTime":28,"updateTime":28,"relativeEntities":2055,"slug":28,"properties":2056,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2058,"statistic":28},[],{"title":2057},{"EN":904},[],[2060,2067],{"id":908,"indexDatabase":2061,"url":914,"indexYears":915,"academicFieldIds":2066,"indexDatabaseRanking":919},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":2062,"label":2063,"description":2064,"key":781,"publicationTags":2065,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[917,918],{"id":921,"indexDatabase":2068,"url":933,"indexYears":28,"academicFieldIds":2073,"indexDatabaseRanking":28},{"id":923,"createTime":28,"updateTime":28,"relativeEntities":2069,"label":2070,"description":2071,"key":930,"publicationTags":2072,"standard":28},[],{"EN":926,"VI":926},{"EN":928,"VI":929},[932,813],[935],{"issue":2075,"pages":2076,"volume":2078},{"VOID":1132},{"VOID":2077},"15-27",{"VOID":2079},"19",{"total":570,"publishYear":2081,"statisticByYear":2082},1997,{"2012":205,"2013":45,"2014":145,"2015":42,"2016":48,"2017":46,"2018":42,"2019":45,"2020":45,"2021":46,"2022":42,"2023":123,"2024":123},"1997-08-01",[932,919],[],{"id":2087,"createTime":2088,"updateTime":2089,"relativeEntities":2090,"slug":2091,"properties":2092,"entityType":964,"verifyStatus":26,"verifyTime":2108,"verifyNote":965,"languages":2109,"translateLanguages":2110,"viewCount":32,"primaryUrl":2111,"fullTextUrl":28,"authors":2112,"publicationType":989,"publisherRelationship":2168,"citationCount":605,"citationInfo":2212,"publishDate":2214,"publishYear":1037,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":2215,"openAccess":28,"references":2216,"isForceReanalyzing":1048},"f8491108-fee0-4a2a-9cfc-d177311902bd","2024-09-11T19:23:09.526+00:00","2025-02-08T05:00:54.424+00:00",[],"Subtilase-like-pro-protein-convertases-from-molecular-specificity-to-therapeutic-applications",{"mag":2093,"keywords":2095,"openalex":2096,"abstract":2098,"title":2101,"pm":2104,"doi":2106},{"VOID":2094},"2121093397",{"VI":1158},{"VOID":2097},"W2121093397",{"EN":2099,"VI":2100},"\u003Cjats:p>Limited proteolysis of most large protein precursors is carried out in vivo by the subtilisin-like pro-protein convertases. Many important biological processes such as peptide hormone synthesis, viral protein processing and receptor maturation involve proteolytic processing by these enzymes, making them potential targets for the development of novel therapeutic agents. However, the efficient development of such molecules requires a better understanding of the molecular mechanisms of proteolytic protein processing. Herein, we review the most recent findings on the molecular aspects of subtilisin-like convertase activity, such as the structural analysis of the proteases, the mechanisms of enzyme\u002Fsubstrate specificity, their interaction with other proteins such as 7B2, and the comparative tissue and cellular distribution of the enzymes and their substrates. These data are then used as a background for the review of the known biological functions of subtilisin-like pro-protein convertases, the reported clinical cases involving proteolytic processing defects and, finally, the ongoing development of new therapeutic inhibitor molecules based on this knowledge.\u003C\u002Fjats:p>","\u003Cjats:p>Proteolysis giới hạn của hầu hết các tiền chất protein lớn được thực hiện trong cơ thể bởi các chuyển thể pro-protein giống subtilisin. Nhiều quá trình sinh học quan trọng như tổng hợp hormone peptide, xử lý protein virus và trưởng thành của thụ thể liên quan đến sự xử lý proteolytic bởi các enzyme này, làm cho chúng trở thành các mục tiêu tiềm năng cho sự phát triển của các chất điều trị mới. Tuy nhiên, sự phát triển hiệu quả của các phân tử như vậy đòi hỏi một hiểu biết sâu sắc hơn về các cơ chế phân tử của quá trình xử lý protein proteolytic. Trong bài viết này, chúng tôi xem xét những phát hiện gần đây nhất về các khía cạnh phân tử của hoạt động chuyển thể giống subtilisin, chẳng hạn như phân tích cấu trúc của các protease, các cơ chế đặc hiệu enzyme\u002Fsubstrate, sự tương tác của chúng với các protein khác như 7B2, và sự phân bố mô và tế bào so sánh của các enzyme và các substrate của chúng. Dữ liệu này sau đó được sử dụng làm nền tảng cho việc xem xét các chức năng sinh học đã biết của các chuyển thể pro-protein giống subtilisin, các trường hợp lâm sàng đã báo cáo liên quan đến các khiếm khuyết trong xử lý proteolytic và, cuối cùng, việc phát triển các phân tử ức chế liệu pháp mới dựa trên kiến thức này.\u003C\u002Fjats:p>",{"EN":2102,"VI":2103},"Subtilase-like pro-protein convertases: from molecular specificity to therapeutic applications","Các chuyển thể pro-protein giống subtilase: từ tính đặc hiệu phân tử đến ứng dụng liệu pháp",{"VOID":2105},"10656993",{"VOID":2107},"10.1677\u002Fjme.0.0240001","2024-09-11T19:23:09.525+00:00",[31],[30],"https:\u002F\u002Fjme.bioscientifica.com\u002Fview\u002Fjournals\u002Fjme\u002F24\u002F1\u002F1.xml",[2113,2132,2149],{"id":2114,"sortIndex":32,"researcher":28,"roles":2115,"affiliations":2116,"properties":2125,"displayName":2129,"givenName":28,"familyName":28},"86159143-0226-4a3e-bbd6-23b69423ec94",[],[2117],{"id":2118,"sortIndex":32,"affiliation":2119,"properties":28},"5f2edd12-8013-4a75-ac13-dbb068a1b7dd",{"id":2118,"createTime":28,"updateTime":28,"relativeEntities":2120,"slug":28,"properties":2121,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2124,"statistic":28},[],{"title":2122},{"VI":2123},"Département de Pharmacologie, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, 3001 12e Avenue nord, Sherbrooke, Québec, Canada J1H 5N4",[],{"orcid":2126,"title":2128,"openalex":2130},{"VOID":2127},"https:\u002F\u002Forcid.org\u002F0000-0003-1505-8056",{"EN":2129},"François Bergeron",{"VOID":2131},"A5102846275",{"id":2133,"sortIndex":40,"researcher":28,"roles":2134,"affiliations":2135,"properties":2142,"displayName":2146,"givenName":28,"familyName":28},"bbb84f10-7b26-44f9-a9c3-6400a15a1e27",[],[2136],{"id":2118,"sortIndex":32,"affiliation":2137,"properties":28},{"id":2118,"createTime":28,"updateTime":28,"relativeEntities":2138,"slug":28,"properties":2139,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2141,"statistic":28},[],{"title":2140},{"VI":2123},[],{"orcid":2143,"title":2145,"openalex":2147},{"VOID":2144},"https:\u002F\u002Forcid.org\u002F0000-0001-6854-8003",{"EN":2146},"Richard Leduc",{"VOID":2148},"A5075307650",{"id":2150,"sortIndex":123,"researcher":28,"roles":2151,"affiliations":2152,"properties":2161,"displayName":2165,"givenName":28,"familyName":28},"aa8eb19c-b34f-434b-9fa2-5d4cc6df183e",[],[2153],{"id":2154,"sortIndex":32,"affiliation":2155,"properties":28},"335d02eb-70a0-42fa-96e8-82434a1e3d1a",{"id":2154,"createTime":28,"updateTime":28,"relativeEntities":2156,"slug":28,"properties":2157,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2160,"statistic":28},[],{"title":2158},{"EN":2159},"Universite de sherbrooke",[],{"orcid":2162,"title":2164,"openalex":2166},{"VOID":2163},"https:\u002F\u002Forcid.org\u002F0000-0001-8123-1991",{"EN":2165},"Robert Day",{"VOID":2167},"A5078845932",{"url":28,"publisher":2169,"properties":2206},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":2170,"slug":872,"properties":2171,"entityType":25,"verifyStatus":884,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":2176,"manageAffiliations":2185,"indexDatabases":2191,"url":936,"thumbnailPath":28,"statistic":28,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"country":2172,"eissn":2173,"issn":2174,"title":2175},{"VOID":875},{"VOID":877},{"VOID":879},{"EN":881},[2177,2181],{"id":887,"createTime":28,"updateTime":28,"relativeEntities":2178,"label":2179,"description":2180,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},{"id":893,"createTime":28,"updateTime":28,"relativeEntities":2182,"label":2183,"description":2184,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":896},{},[2186],{"id":900,"createTime":28,"updateTime":28,"relativeEntities":2187,"slug":28,"properties":2188,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2190,"statistic":28},[],{"title":2189},{"EN":904},[],[2192,2199],{"id":908,"indexDatabase":2193,"url":914,"indexYears":915,"academicFieldIds":2198,"indexDatabaseRanking":919},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":2194,"label":2195,"description":2196,"key":781,"publicationTags":2197,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[917,918],{"id":921,"indexDatabase":2200,"url":933,"indexYears":28,"academicFieldIds":2205,"indexDatabaseRanking":28},{"id":923,"createTime":28,"updateTime":28,"relativeEntities":2201,"label":2202,"description":2203,"key":930,"publicationTags":2204,"standard":28},[],{"EN":926,"VI":926},{"EN":928,"VI":929},[932,813],[935],{"issue":2207,"pages":2208,"volume":2210},{"VOID":1132},{"VOID":2209},"1-22",{"VOID":2211},"24",{"total":605,"publishYear":1037,"statisticByYear":2213},{"2012":48,"2013":46,"2014":48,"2015":40,"2016":123,"2017":46,"2018":123,"2019":123,"2020":40,"2022":46,"2023":45,"2024":40},"2000-02-01",[932,919],[],{"id":2218,"createTime":2219,"updateTime":2220,"relativeEntities":2221,"slug":2222,"properties":2223,"entityType":964,"verifyStatus":26,"verifyTime":2219,"verifyNote":965,"languages":2239,"translateLanguages":2240,"viewCount":32,"primaryUrl":2241,"fullTextUrl":28,"authors":2242,"publicationType":989,"publisherRelationship":2298,"citationCount":360,"citationInfo":2343,"publishDate":2346,"publishYear":2344,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":2347,"openAccess":28,"references":2348,"isForceReanalyzing":1048},"d3d87ab2-df0c-4f42-b205-363b3a96756a","2024-09-26T11:04:00.130+00:00","2025-02-08T05:01:49.577+00:00",[],"PI3K-PTEN-Akt-and-TSC-mTOR-signaling-pathways-ovarian-dysfunction-and-infertility-an-update",{"mag":2224,"keywords":2226,"openalex":2227,"abstract":2229,"title":2232,"pm":2235,"doi":2237},{"VOID":2225},"2115742485",{"VI":1158},{"VOID":2228},"W2115742485",{"EN":2230,"VI":2231},"\u003Cjats:p>Abnormalities in ovarian function, including defective oogenesis and folliculogenesis, represent a key female reproductive deficiency. Accumulating evidence in the literature has shown that the PI3K\u002FPTEN\u002FAkt and TSC\u002FmTOR signaling pathways are critical regulators of ovarian function including quiescence, activation, and survival of primordial follicles, granulosa cell proliferation and differentiation, and meiotic maturation of oocytes. Dysregulation of these signaling pathways may contribute to infertility caused by impaired follicular development, intrafollicular oocyte development, and ovulation. This article reviews the current state of knowledge of the functional role of the PI3K\u002FPTEN\u002FAkt and TSC\u002FmTOR pathways during mammalian oogenesis and folliculogenesis and their association with female infertility.\u003C\u002Fjats:p>","\u003Cjats:p>Các bất thường trong chức năng buồng trứng, bao gồm sự bất thường trong sinh tinh và sự hình thành nang, là một thiếu hụt chính trong sinh sản nữ. Các bằng chứng ngày càng tăng trong tài liệu đã chỉ ra rằng các đường dẫn tín hiệu PI3K\u002FPTEN\u002FAkt và TSC\u002FmTOR là những yếu tố điều chỉnh quan trọng chức năng buồng trứng, bao gồm sự ngủ đông, kích hoạt và tồn tại của các nang nguyên thủy, sự tăng sinh và biệt hóa của tế bào nang, cũng như sự trưởng thành giảm nhiễm của trứng. Sự rối loạn trong các đường dẫn tín hiệu này có thể góp phần vào tình trạng vô sinh do sự phát triển nang bị suy yếu, sự phát triển trứng trong nang, và sự rụng trứng. Bài báo này tổng quan về trạng thái hiện tại của kiến thức về vai trò chức năng của các đường dẫn PI3K\u002FPTEN\u002FAkt và TSC\u002FmTOR trong quá trình sinh tinh và hình thành nang ở động vật có vú và mối quan hệ của chúng với vô sinh nữ.\u003C\u002Fjats:p>",{"EN":2233,"VI":2234},"PI3K\u002FPTEN\u002FAkt and TSC\u002FmTOR signaling pathways, ovarian dysfunction, and infertility: an update","Đường dẫn tín hiệu PI3K\u002FPTEN\u002FAkt và TSC\u002FmTOR, rối loạn chức năng buồng trứng và vô sinh: một cập nhật",{"VOID":2236},"25312969",{"VOID":2238},"10.1530\u002Fjme-14-0220",[31],[30],"https:\u002F\u002Fjme.bioscientifica.com\u002Fview\u002Fjournals\u002Fjme\u002F53\u002F3\u002FR103.xml",[2243,2262,2279],{"id":2244,"sortIndex":32,"researcher":28,"roles":2245,"affiliations":2246,"properties":2255,"displayName":2259,"givenName":28,"familyName":28},"5f24d0d1-68cc-4e6f-be0d-0520eb555571",[],[2247],{"id":2248,"sortIndex":32,"affiliation":2249,"properties":28},"49e113fd-42e1-4d39-901c-a43faa3efbe2",{"id":2248,"createTime":28,"updateTime":28,"relativeEntities":2250,"slug":28,"properties":2251,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2254,"statistic":28},[],{"title":2252},{"EN":2253},"Post-Graduate Department of PathologyDepartment of BiochemistryKing George's Medical University, Lucknow 226003, Uttar Pradesh, 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Molecular Human Reproduction, 15, 765, 10.1093\u002Fmolehr\u002Fgap092",{"doi":2352},"10.1093\u002Fmolehr\u002Fgap092",{"id":28,"text":2354,"url":28,"identifiers":2355},"2010, Human Molecular Genetics, 19, 397, 10.1093\u002Fhmg\u002Fddp483",{"doi":2356},"10.1093\u002Fhmg\u002Fddp483",{"id":28,"text":2358,"url":28,"identifiers":2359},"Adhikari, 2012, 7, e39034, 10.1371\u002Fjournal.pone.0039034",{"doi":2360},"10.1371\u002Fjournal.pone.0039034",{"id":28,"text":2362,"url":28,"identifiers":2363},"2013, 8, e53810, 10.1371\u002Fjournal.pone.0053810",{"doi":2364},"10.1371\u002Fjournal.pone.0053810",{"id":28,"text":2366,"url":28,"identifiers":2367},"2004, Journal of Biological Chemistry, 279, 19431, 10.1074\u002Fjbc.M401235200",{"doi":2368},"10.1074\u002Fjbc.M401235200",{"id":28,"text":2370,"url":28,"identifiers":2371},"Albertini, 1994, Microscopy research and technique, 27, 125, 10.1002\u002Fjemt.1070270206",{"doi":2372},"10.1002\u002Fjemt.1070270206",{"id":28,"text":2374,"url":28,"identifiers":2375},"Allan, 2006, Journal of Endocrinology, 188, 549, 10.1677\u002Fjoe.1.06614",{"doi":2376},"10.1677\u002Fjoe.1.06614",{"id":28,"text":2378,"url":28,"identifiers":2379},"2014, Human Reproduction, 29, 97, 10.1093\u002Fhumrep\u002Fdet388",{"doi":2380},"10.1093\u002Fhumrep\u002Fdet388",{"id":28,"text":2382,"url":28,"identifiers":2383},"2014, 9, e96210, 10.1371\u002Fjournal.pone.0096210",{"doi":2384},"10.1371\u002Fjournal.pone.0096210",{"id":28,"text":2386,"url":28,"identifiers":2387},"Bao, 1998, Journal of Animal Science, 76, 1903, 10.2527\u002F1998.7671903x",{"doi":2388},"10.2527\u002F1998.7671903x",{"id":28,"text":2390,"url":28,"identifiers":2391},"2012, JOURNAL OF OVARIAN RESEARCH, 5, 32, 10.1186\u002F1757-2215-5-32",{"doi":2392},"10.1186\u002F1757-2215-5-32",{"id":28,"text":2394,"url":28,"identifiers":2395},"2013, BMC genomics [electronic resource], 14, 904, 10.1186\u002F1471-2164-14-904",{"doi":2396},"10.1186\u002F1471-2164-14-904",{"id":28,"text":2398,"url":28,"identifiers":2399},"2010, Biology of Reproduction, 82, 246, 10.1095\u002Fbiolreprod.109.077925",{"doi":2400},"10.1095\u002Fbiolreprod.109.077925",{"id":28,"text":2402,"url":28,"identifiers":2403},"Cahill, 2002, BMJ, 325, 28, 10.1136\u002Fbmj.325.7354.28",{"doi":2404},"10.1136\u002Fbmj.325.7354.28",{"id":28,"text":2406,"url":28,"identifiers":2407},"Cecconi, 2010, Reproductive biomedicine online, 20, 35, 10.1016\u002Fj.rbmo.2009.10.011",{"doi":2408},"10.1016\u002Fj.rbmo.2009.10.011",{"id":28,"text":2410,"url":28,"identifiers":2411},"2007, Endocrinology, 148, 3580, 10.1210\u002Fen.2007-0088",{"doi":2412},"10.1210\u002Fen.2007-0088",{"id":28,"text":2414,"url":28,"identifiers":2415},"2009, Journal of Endocrinology, 202, 407, 10.1677\u002FJOE-09-0109",{"doi":2416},"10.1677\u002FJOE-09-0109",{"id":28,"text":2418,"url":28,"identifiers":2419},"Choi, 2010, Fertility and sterility, 93, 2532, 10.1016\u002Fj.fertnstert.2009.11.021",{"doi":2420},"10.1016\u002Fj.fertnstert.2009.11.021",{"id":28,"text":2422,"url":28,"identifiers":2423},"Choi, 2011, Fertility and sterility, 95, 1482, 10.1016\u002Fj.fertnstert.2010.06.006",{"doi":2424},"10.1016\u002Fj.fertnstert.2010.06.006",{"id":28,"text":2426,"url":28,"identifiers":2427},"2013, Reproduction, 147, 73, 10.1530\u002FREP-13-0386",{"doi":2428},"10.1530\u002FREP-13-0386",{"id":28,"text":2430,"url":28,"identifiers":2431},"2008, Journal of Cell Science, 121, 3890, 10.1242\u002Fjcs.036400",{"doi":2432},"10.1242\u002Fjcs.036400",{"id":28,"text":2434,"url":28,"identifiers":2435},"Fair, 1997, Molecular reproduction and development, 46, 208, 10.1002\u002F(SICI)1098-2795(199702)46:2\u003C208::AID-MRD11>3.0.CO;2-X",{"doi":2436},"10.1002\u002F(SICI)1098-2795(199702)46:2\u003C208::AID-MRD11>3.0.CO;2-X",{"id":28,"text":2438,"url":28,"identifiers":2439},"Fair, 1997, Anatomy and embryology, 195, 327, 10.1007\u002Fs004290050052",{"doi":2440},"10.1007\u002Fs004290050052",{"id":28,"text":2442,"url":28,"identifiers":2443},"2009, JOURNAL OF OVARIAN RESEARCH, 2, 17, 10.1186\u002F1757-2215-2-17",{"doi":2444},"10.1186\u002F1757-2215-2-17",{"id":28,"text":2446,"url":28,"identifiers":2447},"2008, Molecular Endocrinology, 22, 2128, 10.1210\u002Fme.2008-0095",{"doi":2448},"10.1210\u002Fme.2008-0095",{"id":28,"text":2450,"url":28,"identifiers":2451},"Farini, 2007, Developmental biology, 306, 572, 10.1016\u002Fj.ydbio.2007.03.031",{"doi":2452},"10.1016\u002Fj.ydbio.2007.03.031",{"id":28,"text":2454,"url":28,"identifiers":2455},"Fassnacht, 2006, Current medicinal chemistry, 13, 1397, 10.2174\u002F092986706776872943",{"doi":2456},"10.2174\u002F092986706776872943",{"id":28,"text":2458,"url":28,"identifiers":2459},"Flanagan, 1991, Cell, 64, 1025, 10.1016\u002F0092-8674(91)90326-T",{"doi":2460},"10.1016\u002F0092-8674(91)90326-T",{"id":28,"text":2462,"url":28,"identifiers":2463},"2014, Biology of Reproduction, 90, 86, 10.1095\u002Fbiolreprod.113.115089",{"doi":2464},"10.1095\u002Fbiolreprod.113.115089",{"id":28,"text":2466,"url":28,"identifiers":2467},"2011, Reproduction, 141, 759, 10.1530\u002FREP-10-0489",{"doi":2468},"10.1530\u002FREP-10-0489",{"id":28,"text":2470,"url":28,"identifiers":2471},"Goto, 2007, Journal of assisted reproduction and genetics, 24, 541, 10.1007\u002Fs10815-007-9156-3",{"doi":2472},"10.1007\u002Fs10815-007-9156-3",{"id":28,"text":2474,"url":28,"identifiers":2475},"2009, Reproduction, 137, 835, 10.1530\u002FREP-08-0315",{"doi":2476},"10.1530\u002FREP-08-0315",{"id":28,"text":2478,"url":28,"identifiers":2479},"Greenfeld, 2007, Reproduction, 133, 865, 10.1530\u002FREP-06-0270",{"doi":2480},"10.1530\u002FREP-06-0270",{"id":28,"text":2482,"url":28,"identifiers":2483},"Greenseid, 2011, Reproductive Sciences, 18, 892, 10.1177\u002F1933719111398502",{"doi":2484},"10.1177\u002F1933719111398502",{"id":28,"text":2486,"url":28,"identifiers":2487},"Gu, 2011, 6, 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10.1002\u002Fmrd.20150",{"doi":2508},"10.1002\u002Fmrd.20150",{"id":28,"text":2510,"url":28,"identifiers":2511},"2013, 8, e540552",{},{"id":28,"text":2513,"url":28,"identifiers":2514},"Huansheng, 2011, Biochemical and biophysical research communications, 410, 659, 10.1016\u002Fj.bbrc.2011.06.050",{"doi":2515},"10.1016\u002Fj.bbrc.2011.06.050",{"id":28,"text":2517,"url":28,"identifiers":2518},"2012, PNAS, 109, E2979, 10.1073\u002Fpnas.1205661109",{"doi":2519},"10.1073\u002Fpnas.1205661109",{"id":28,"text":2521,"url":28,"identifiers":2522},"Iguchi, 1986, Teratology, 34, 29, 10.1002\u002Ftera.1420340105",{"doi":2523},"10.1002\u002Ftera.1420340105",{"id":28,"text":2525,"url":28,"identifiers":2526},"Irusta, 2010, Molecular and cellular endocrinology, 325, 93, 10.1016\u002Fj.mce.2010.04.018",{"doi":2527},"10.1016\u002Fj.mce.2010.04.018",{"id":28,"text":2529,"url":28,"identifiers":2530},"Jagarlamudi, 2009, 4, e6186, 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10.1016\u002Fj.ydbio.2008.06.017",{"doi":2551},"10.1016\u002Fj.ydbio.2008.06.017",{"id":28,"text":2553,"url":28,"identifiers":2554},"John, 2009, Developmental biology, 331, 292, 10.1016\u002Fj.ydbio.2009.05.546",{"doi":2555},"10.1016\u002Fj.ydbio.2009.05.546",{"id":28,"text":2557,"url":28,"identifiers":2558},"Jumayev, 2012, Nagoya journal of medical science, 74, 273",{},{"id":28,"text":2560,"url":28,"identifiers":2561},"Kalous, 2006, Biology of the cell \u002F under the auspices of the European Cell Biology Organization, 98, 111, 10.1042\u002FBC20050020",{"doi":2562},"10.1042\u002FBC20050020",{"id":28,"text":2564,"url":28,"identifiers":2565},"2009, Reproduction, 138, 645, 10.1530\u002FREP-08-0461",{"doi":2566},"10.1530\u002FREP-08-0461",{"id":28,"text":2568,"url":28,"identifiers":2569},"2013, PNAS, 110, 17474, 10.1073\u002Fpnas.1312830110",{"doi":2570},"10.1073\u002Fpnas.1312830110",{"id":28,"text":2572,"url":28,"identifiers":2573},"2008, Development, 135, 869, 10.1242\u002Fdev.013474",{"doi":2574},"10.1242\u002Fdev.013474",{"id":28,"text":2576,"url":28,"identifiers":2577},"Klinge, 2001, Nucleic Acids Research, 29, 2905, 10.1093\u002Fnar\u002F29.14.2905",{"doi":2578},"10.1093\u002Fnar\u002F29.14.2905",{"id":28,"text":2580,"url":28,"identifiers":2581},"2013, Molecular reproduction and development, 80, 334, 10.1002\u002Fmrd.22166",{"doi":2582},"10.1002\u002Fmrd.22166",{"id":28,"text":2584,"url":28,"identifiers":2585},"Laplante, 2012, Cell, 149, 274, 10.1016\u002Fj.cell.2012.03.017",{"doi":2586},"10.1016\u002Fj.cell.2012.03.017",{"id":28,"text":2588,"url":28,"identifiers":2589},"La Sala, 2010, Experimental cell research, 316, 1716, 10.1016\u002Fj.yexcr.2010.03.024",{"doi":2590},"10.1016\u002Fj.yexcr.2010.03.024",{"id":28,"text":2592,"url":28,"identifiers":2593},"Lee, 2012, Molecular reproduction and development, 79, 356, 10.1002\u002Fmrd.22035",{"doi":2594},"10.1002\u002Fmrd.22035",{"id":28,"text":2596,"url":28,"identifiers":2597},"2013, Development, 140, 2075, 10.1242\u002Fdev.093864",{"doi":2598},"10.1242\u002Fdev.093864",{"id":28,"text":2600,"url":28,"identifiers":2601},"2010, PNAS, 107, 10280, 10.1073\u002Fpnas.1001198107",{"doi":2602},"10.1073\u002Fpnas.1001198107",{"id":28,"text":2604,"url":28,"identifiers":2605},"Liu, 2007, Development, 134, 199, 10.1242\u002Fdev.02667",{"doi":2606},"10.1242\u002Fdev.02667",{"id":28,"text":2608,"url":28,"identifiers":2609},"2013, Molecular Endocrinology, 27, 238, 10.1210\u002Fme.2012-1296",{"doi":2610},"10.1210\u002Fme.2012-1296",{"id":28,"text":2612,"url":28,"identifiers":2613},"2012, Reproduction, 144, 595, 10.1530\u002FREP-12-0225",{"doi":2614},"10.1530\u002FREP-12-0225",{"id":28,"text":2616,"url":28,"identifiers":2617},"2010, Reproduction, 139, 139, 10.1530\u002FREP-09-0050",{"doi":2618},"10.1530\u002FREP-09-0050",{"id":28,"text":2620,"url":28,"identifiers":2621},"Manning, 2007, Cell, 129, 1261, 10.1016\u002Fj.cell.2007.06.009",{"doi":2622},"10.1016\u002Fj.cell.2007.06.009",{"id":28,"text":2624,"url":28,"identifiers":2625},"2012, Developmental biology, 375, 140",{},{"id":28,"text":2627,"url":28,"identifiers":2628},"2012, Molecular Human Reproduction, 18, 96, 10.1093\u002Fmolehr\u002Fgar083",{"doi":2629},"10.1093\u002Fmolehr\u002Fgar083",{"id":28,"text":2631,"url":28,"identifiers":2632},"2012, PLOS MEDICINE, 9, 1001356e, 10.1371\u002Fjournal.pmed.1001356",{"doi":2633},"10.1371\u002Fjournal.pmed.1001356",{"id":28,"text":2635,"url":28,"identifiers":2636},"2014, Molecular reproduction and development, 81, 363, 10.1002\u002Fmrd.22305",{"doi":2637},"10.1002\u002Fmrd.22305",{"id":28,"text":2639,"url":28,"identifiers":2640},"McCoshen, 1975, Experientia, 31, 589, 10.1007\u002FBF01932475",{"doi":2641},"10.1007\u002FBF01932475",{"id":28,"text":2643,"url":28,"identifiers":2644},"McLaughlin, 2011, Fertility and sterility, 96, 1154, 10.1016\u002Fj.fertnstert.2011.08.040",{"doi":2645},"10.1016\u002Fj.fertnstert.2011.08.040",{"id":28,"text":2647,"url":28,"identifiers":2648},"2014, Molecular Human Reproduction, 20, 736, 10.1093\u002Fmolehr\u002Fgau037",{"doi":2649},"10.1093\u002Fmolehr\u002Fgau037",{"id":28,"text":2651,"url":28,"identifiers":2652},"2007, SOCIETY OF REPRODUCTION AND FERTILITY SUPPLEMENT, 64, 55",{},{"id":28,"text":2654,"url":28,"identifiers":2655},"Mork, 2012, Mechanisms of development, 128, 591, 10.1016\u002Fj.mod.2011.12.005",{"doi":2656},"10.1016\u002Fj.mod.2011.12.005",{"id":28,"text":2658,"url":28,"identifiers":2659},"2012, Molecular Endocrinology, 26, 1732, 10.1210\u002Fme.2012-1106",{"doi":2660},"10.1210\u002Fme.2012-1106",{"id":28,"text":2662,"url":28,"identifiers":2663},"2013, Molecular and cellular endocrinology, 366, 81, 10.1016\u002Fj.mce.2012.12.004",{"doi":2664},"10.1016\u002Fj.mce.2012.12.004",{"id":28,"text":2666,"url":28,"identifiers":2667},"2013, NATURE COMMUNICATIONS, 4, 1843, 10.1038\u002Fncomms2861",{"doi":2668},"10.1038\u002Fncomms2861",{"id":28,"text":2670,"url":28,"identifiers":2671},"2007, PNAS, 104, 187, 10.1073\u002Fpnas.0609923104",{"doi":2672},"10.1073\u002Fpnas.0609923104",{"id":28,"text":2674,"url":28,"identifiers":2675},"PETERS, 1975, Reproduction, 45, 559, 10.1530\u002Fjrf.0.0450559",{"doi":2676},"10.1530\u002Fjrf.0.0450559",{"id":28,"text":2678,"url":28,"identifiers":2679},"2013, Veterin  rn   medic  na, 10, 505",{},{"id":28,"text":2681,"url":28,"identifiers":2682},"Pisarska, 2009, Fertility and sterility, 91, 1392, 10.1016\u002Fj.fertnstert.2008.04.054",{"doi":2683},"10.1016\u002Fj.fertnstert.2008.04.054",{"id":28,"text":2685,"url":28,"identifiers":2686},"Rao, 2011, 6, e20754, 10.1371\u002Fjournal.pone.0020754",{"doi":2687},"10.1371\u002Fjournal.pone.0020754",{"id":28,"text":2689,"url":28,"identifiers":2690},"Reddy, 2005, Developmental biology, 281, 160, 10.1016\u002Fj.ydbio.2005.02.013",{"doi":2691},"10.1016\u002Fj.ydbio.2005.02.013",{"id":28,"text":2693,"url":28,"identifiers":2694},"Reddy, 2008, Science, 319, 611, 10.1126\u002Fscience.1152257",{"doi":2695},"10.1126\u002Fscience.1152257",{"id":28,"text":2697,"url":28,"identifiers":2698},"2009, Human Molecular Genetics, 18, 2813, 10.1093\u002Fhmg\u002Fddp217",{"doi":2699},"10.1093\u002Fhmg\u002Fddp217",{"id":28,"text":2701,"url":28,"identifiers":2702},"2013, Genetics, 195, 349, 10.1534\u002Fgenetics.113.154005",{"doi":2703},"10.1534\u002Fgenetics.113.154005",{"id":28,"text":2705,"url":28,"identifiers":2706},"2008, JOURNAL OF OVARIAN RESEARCH, 1, 2, 10.1186\u002F1757-2215-1-2",{"doi":2707},"10.1186\u002F1757-2215-1-2",{"id":28,"text":2709,"url":28,"identifiers":2710},"Smith, 1994, Journal of Animal Science, 72, 1857, 10.2527\u002F1994.7271857x",{"doi":2711},"10.2527\u002F1994.7271857x",{"id":28,"text":2713,"url":28,"identifiers":2714},"Su, 2004, Developmental biology, 276, 64, 10.1016\u002Fj.ydbio.2004.08.020",{"doi":2715},"10.1016\u002Fj.ydbio.2004.08.020",{"id":28,"text":2717,"url":28,"identifiers":2718},"Sugiura, 2005, Developmental biology, 279, 20, 10.1016\u002Fj.ydbio.2004.11.027",{"doi":2719},"10.1016\u002Fj.ydbio.2004.11.027",{"id":28,"text":2721,"url":28,"identifiers":2722},"2012, Endocrinology, 153, 404, 10.1210\u002Fen.2011-1191",{"doi":2723},"10.1210\u002Fen.2011-1191",{"id":28,"text":2725,"url":28,"identifiers":2726},"2013, Biology of Reproduction, 88, 103, 10.1095\u002Fbiolreprod.112.105791",{"doi":2727},"10.1095\u002Fbiolreprod.112.105791",{"id":28,"text":2729,"url":28,"identifiers":2730},"2006, REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 4, 19, 10.1186\u002F1477-7827-4-19",{"doi":2731},"10.1186\u002F1477-7827-4-19",{"id":28,"text":2733,"url":28,"identifiers":2734},"Stanfield, 2009, Biology of Reproduction, 81, 16, 10.1095\u002Fbiolreprod.108.074898",{"doi":2735},"10.1095\u002Fbiolreprod.108.074898",{"id":28,"text":2737,"url":28,"identifiers":2738},"Tomek, 2005, Reproduction, 130, 423, 10.1530\u002Frep.1.00754",{"doi":2739},"10.1530\u002Frep.1.00754",{"id":28,"text":2741,"url":28,"identifiers":2742},"Vaccari, 2008, Developmental biology, 316, 124, 10.1016\u002Fj.ydbio.2008.01.018",{"doi":2743},"10.1016\u002Fj.ydbio.2008.01.018",{"id":28,"text":2745,"url":28,"identifiers":2746},"2013, FRONTIERS IN ONCOLOGY, 3, 165article",{},{"id":28,"text":2748,"url":28,"identifiers":2749},"2012, Journal of Biological Chemistry, 287, 10166, 10.1074\u002Fjbc.M111.293274",{"doi":2750},"10.1074\u002Fjbc.M111.293274",{"id":28,"text":2752,"url":28,"identifiers":2753},"2014, Journal of Biological Chemistry, 289, 8299, 10.1074\u002Fjbc.M113.532952",{"doi":2754},"10.1074\u002Fjbc.M113.532952",{"id":28,"text":2756,"url":28,"identifiers":2757},"Watkins, 2006, Fertility and sterility, 86, 1518, 10.1016\u002Fj.fertnstert.2006.03.054",{"doi":2758},"10.1016\u002Fj.fertnstert.2006.03.054",{"id":28,"text":2760,"url":28,"identifiers":2761},"Wullschleger, 2006, Cell, 124, 471, 10.1016\u002Fj.cell.2006.01.016",{"doi":2762},"10.1016\u002Fj.cell.2006.01.016",{"id":28,"text":2764,"url":28,"identifiers":2765},"Xu, 1995, Biology of Reproduction, 53, 951, 10.1095\u002Fbiolreprod53.4.951",{"doi":2766},"10.1095\u002Fbiolreprod53.4.951",{"id":28,"text":2768,"url":28,"identifiers":2769},"Yaba, 2008, Reproductive Sciences, 15, 128, 10.1177\u002F1933719107312037",{"doi":2770},"10.1177\u002F1933719107312037",{"id":28,"text":2772,"url":28,"identifiers":2773},"Yan, 2001, Molecular Endocrinology, 15, 854, 10.1210\u002Fme.15.6.854",{"doi":2774},"10.1210\u002Fme.15.6.854",{"id":28,"text":2776,"url":28,"identifiers":2777},"Yu, 2011, 6, e21415, 10.1371\u002Fjournal.pone.0021415",{"doi":2778},"10.1371\u002Fjournal.pone.0021415",{"id":28,"text":2780,"url":28,"identifiers":2781},"Schubert, 2013, Biology of Reproduction, 88, 1, 10.1095\u002Fbiolreprod.112.105957",{"doi":2782},"10.1095\u002Fbiolreprod.112.105957",{"id":28,"text":2784,"url":28,"identifiers":2785},"2013, The Chinese journal of physiology, 56, 298",{},{"id":28,"text":2787,"url":28,"identifiers":2788},"2013, Gene, 523, 82, 10.1016\u002Fj.gene.2013.03.039",{"doi":2789},"10.1016\u002Fj.gene.2013.03.039",{"id":28,"text":2791,"url":28,"identifiers":2792},"2014, Human Molecular Genetics, 23, 920, 10.1093\u002Fhmg\u002Fddt486",{"doi":2793},"10.1093\u002Fhmg\u002Fddt486",{"id":2795,"createTime":2796,"updateTime":2797,"relativeEntities":2798,"slug":2799,"properties":2800,"entityType":964,"verifyStatus":884,"verifyTime":2796,"verifyNote":1757,"languages":2816,"translateLanguages":2817,"viewCount":32,"primaryUrl":2818,"fullTextUrl":28,"authors":2819,"publicationType":989,"publisherRelationship":2884,"citationCount":520,"citationInfo":2928,"publishDate":2931,"publishYear":2929,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":2932,"openAccess":28,"references":2933,"isForceReanalyzing":1048},"e7599ab5-9a72-41f8-8cd6-8bcf33e4ce8b","2024-09-11T18:50:18.536+00:00","2025-02-08T05:02:45.794+00:00",[],"Cloning-and-sequence-analysis-of-the-cDNA-encoding-P-450-aromatase-P450arom-from-a-rainbow-trout-Oncorhynchus-mykiss-ovary-relationship-between-the-amount-of-P450arom-mRNA-and-the-production-of-oestradiol-17%CE%B2-in-the-ovary",{"mag":2801,"keywords":2803,"openalex":2804,"abstract":2806,"title":2809,"pm":2812,"doi":2814},{"VOID":2802},"2164788243",{"VI":1158},{"VOID":2805},"W2164788243",{"EN":2807,"VI":2808},"\u003Cjats:title>ABSTRACT\u003C\u002Fjats:title>\n\u003Cjats:p>The enzyme aromatase P-450 (P450arom) catalyses the conversion of androgen to oestrogen. A cDNA insert encoding P450arom was isolated from a rainbow trout (\u003Cjats:italic>Oncorhynchus mykiss\u003C\u002Fjats:italic>) ovary cDNA library. The insert was sequenced and found to contain an open-reading frame predicted to encode a protein of 522 amino acid residues. The deduced polypeptide is 52% homologous with human, mouse and rat P450arom and 53% homologous with that of chicken. The insert was confirmed to encode P450arom by introducing it into COS-1 monkey kidney tumour cells (COS-1 cells) and detecting the conversion of testosterone to oestradiol-17β by radioimmunoassay. The N-terminal region of the deduced polypeptide was 19 amino acids longer than that of the other four species, and was found by hydropathy plotting to be very hydrophobic.\u003C\u002Fjats:p>\n\u003Cjats:p>Northern blot analysis revealed 2.6kb RNA transcripts which were present in the trout ovary during vitellogenesis and hybridized to the cDNA insert. In preparations from subsequent stages of ovarian development, no RNA transcripts hybridized to the probe. Since the RNA transcripts are present only during the stage of oestradiol-β production by the ovarian follicles, oestradiol-17β production may be regulated, in part, by the amount of P450arom mRNA present.\u003C\u002Fjats:p>","\u003Cjats:title>TÓM TẮT\u003C\u002Fjats:title>\n\u003Cjats:p>Enzym aromatase P-450 (P450arom) xúc tác quá trình chuyển đổi androgen thành estrogen. Một đoạn cDNA mã hóa P450arom đã được tách từ thư viện cDNA của buồng trứng cá hồi cầu vồng (\u003Cjats:italic>Oncorhynchus mykiss\u003C\u002Fjats:italic>). Đoạn này đã được giải trình tự và phát hiện có một khung đọc mở dự đoán mã hóa cho một protein có 522 dư lượng amino acid. Polypeptide suy diễn có độ tương đồng 52% với P450arom của người, chuột và chuột lang, và 53% với của gà. Đoạn đã được xác nhận mã hóa P450arom bằng cách đưa nó vào các tế bào khối u thận khỉ COS-1 (tế bào COS-1) và phát hiện sự chuyển đổi testosterone thành oestradiol-17β bằng phương pháp đo miễn dịch phóng xạ. Vùng đầu N của polypeptide suy diễn dài hơn 19 amino acid so với các loài còn lại và được phát hiện bằng đồ thị độ ưa nước là rất kị nước.\u003C\u002Fjats:p>\n\u003Cjats:p>Phân tích Northern blot cho thấy có các bản sao RNA dài 2.6kb có mặt trong buồng trứng cá hồi trong quá trình vitellogenesis và đã kết hợp với đoạn cDNA. Trong các mẫu từ các giai đoạn phát triển buồng trứng tiếp theo, không có bản sao RNA nào kết hợp với đầu dò. Vì các bản sao RNA chỉ có mặt trong giai đoạn sản xuất oestradiol-β bởi các nang trứng, sản xuất oestradiol-17β có thể được điều chỉnh, một phần, bởi lượng mRNA P450arom có mặt.\u003C\u002Fjats:p>",{"EN":2810,"VI":2811},"Cloning and sequence analysis of the cDNA encoding P-450 aromatase (P450arom) from a rainbow trout (Oncorhynchus mykiss) ovary; relationship between the amount of P450arom mRNA and the production of oestradiol-17β in the ovary","Khảo sát và phân tích trình tự cDNA mã hóa P-450 aromatase (P450arom) từ buồng trứng cá hồi cầu vồng (Oncorhynchus mykiss); mối quan hệ giữa lượng mRNA P450arom và sản xuất oestradiol-17β trong buồng 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