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SARS‐CoV-2, suy hô hấp, hệ thần kinh trung ương, viêm phổi coronavirus, hội chứng suy hô hấp cấp tính, triệu chứng thần kinh",{"VOID":922},"7228394",{"VOID":924},"W3007201727",{"EN":926,"VI":927},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Following the severe acute respiratory syndrome coronavirus (SARS‐CoV) and Middle East respiratory syndrome coronavirus (MERS‐CoV), another highly pathogenic coronavirus named SARS‐CoV‐2 (previously known as 2019‐nCoV) emerged in December 2019 in Wuhan, China, and rapidly spreads around the world. This virus shares highly homological sequence with SARS‐CoV, and causes acute, highly lethal pneumonia coronavirus disease 2019 (COVID‐19) with clinical symptoms similar to those reported for SARS‐CoV and MERS‐CoV. The most characteristic symptom of patients with COVID‐19 is respiratory distress, and most of the patients admitted to the intensive care could not breathe spontaneously. Additionally, some patients with COVID‐19 also showed neurologic signs, such as headache, nausea, and vomiting. Increasing evidence shows that coronaviruses are not always confined to the respiratory tract and that they may also invade the central nervous system inducing neurological diseases. The infection of SARS‐CoV has been reported in the brains from both patients and experimental animals, where the brainstem was heavily infected. Furthermore, some coronaviruses have been demonstrated able to spread via a synapse‐connected route to the medullary cardiorespiratory center from the mechanoreceptors and chemoreceptors in the lung and lower respiratory airways. Considering the high similarity between SARS‐CoV and SARS‐CoV2, it remains to make clear whether the potential invasion of SARS‐CoV2 is partially responsible for the acute respiratory failure of patients with COVID‐19. Awareness of this may have a guiding significance for the prevention and treatment of the SARS‐CoV‐2‐induced respiratory failure.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Theo sau hội chứng suy hô hấp cấp tính nặng coronavirus (SARS‐CoV) và hội chứng hô hấp Trung Đông coronavirus (MERS‐CoV), một loại coronavirus gây bệnh nặng khác được gọi là SARS‐CoV-2 (trước đây được biết đến với tên 2019‐nCoV) đã xuất hiện vào tháng 12 năm 2019 tại Vũ Hán, Trung Quốc, và lan nhanh ra khắp thế giới. Virus này có trình tự giống cao với SARS‐CoV và gây ra bệnh viêm phổi coronavirus cấp tính nguy hiểm chết người năm 2019 (COVID‐19) với các triệu chứng lâm sàng tương tự như các triệu chứng báo cáo cho SARS‐CoV và MERS‐CoV. Triệu chứng đặc trưng nhất của bệnh nhân COVID‐19 là suy hô hấp, và hầu hết các bệnh nhân nhập viện chăm sóc đặc biệt không thể thở tự phát. Ngoài ra, một số bệnh nhân COVID-19 cũng có biểu hiện triệu chứng thần kinh, như đau đầu, buồn nôn và nôn. Nhiều bằng chứng cho thấy rằng các coronavirus không chỉ giới hạn ở đường hô hấp mà còn có thể xâm nhập hệ thần kinh trung ương gây ra các bệnh thần kinh. Nhiễm trùng SARS‐CoV đã được báo cáo ở não của cả bệnh nhân và động vật thí nghiệm, nơi thân não bị nhiễm nghiêm trọng. Hơn nữa, một số coronavirus đã được chứng minh có khả năng lan truyền qua đường kết nối synapse đến trung tâm hô hấp tim mạch từ các thụ thể cơ học và hóa học trong phổi và đường hô hấp dưới. Xét sự tương đồng cao giữa SARS‐CoV và SARS‐CoV-2, vẫn cần làm rõ liệu khả năng xâm nhập tiềm tàng của SARS‐CoV-2 có phải là phần nào chịu trách nhiệm cho suy hô hấp cấp tính của bệnh nhân COVID-19 hay không. Nhận thức về điều này có thể mang ý nghĩa chỉ đạo cho công tác phòng ngừa và điều trị suy hô hấp do SARS‐CoV-2 gây ra.\u003C\u002Fjats:p>",{"EN":929,"VI":930},"The neuroinvasive potential of SARS‐CoV2 may play a role in the respiratory failure of COVID‐19 patients","Tính thâm nhập hệ thần kinh trung ương của SARS‐CoV-2 có thể đóng vai trò gây suy hô hấp ở bệnh nhân COVID-19",{"VOID":932},"32104915",{"VOID":934},"10.1002\u002Fjmv.25728",[130],[937],"VI","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fjmv.25728",[940,959,978],{"id":941,"sortIndex":25,"researcher":24,"roles":942,"affiliations":943,"properties":952,"displayName":956,"givenName":24,"familyName":24},"ebaef11f-cf5d-4265-bcdd-e232d9836e72",[],[944],{"id":945,"sortIndex":25,"affiliation":946,"properties":24},"7044d5d5-df0f-44e5-a3ad-fdd81a95f4bd",{"id":945,"createTime":24,"updateTime":24,"relativeEntities":947,"slug":24,"properties":948,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":951,"statistic":24},[],{"title":949},{"EN":950},"Department of Histology and Embryology, College of Basic Medical Sciences, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, 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L, Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study, MedRxiv",{},{"id":1185,"createTime":1186,"updateTime":1186,"relativeEntities":1187,"slug":1188,"properties":1189,"entityType":125,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":1196,"translateLanguages":24,"viewCount":25,"primaryUrl":1197,"fullTextUrl":24,"authors":1198,"publicationType":542,"publisherRelationship":1206,"citationCount":24,"citationInfo":24,"publishDate":1254,"publishYear":904,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":1255,"openAccess":24,"references":24,"isForceReanalyzing":669},"cf560779-5768-4fe9-887d-bcc65e292c18","2026-02-03T03:13:05.944+00:00",[],"Epidemiology-of-COVID-19-A-systematic-review-and-meta-analysis-of-clinical-characteristics-risk-factors-and-outcomes-",{"title":1190,"doi":1192,"abstract":1194},{"EN":1191},"Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes.",{"VOID":1193},"10.1002\u002Fjmv.26424",{"EN":1195},"Coronavirus disease 2019 (COVID-19) has become a pandemic, but its reported characteristics and outcomes vary greatly amongst studies. We determined pooled estimates for clinical characteristics and outcomes in COVID-19 patients including subgroups by disease severity (based on World Health Organization Interim Guidance Report or Infectious Disease Society of America\u002FAmerican Thoracic Society criteria) and by country\u002Fregion. We searched Pubmed, Embase, Scopus, Cochrane, Chinese Medical Journal, and preprint databases from 1 January 2020 to 6 April 2020. Studies of laboratory-confirmed COVID-19 patients with relevant data were included. Two reviewers independently performed study selection and data extraction. From 6007 articles, 212 studies from 11 countries\u002Fregions involving 281 461 individuals were analyzed. Overall, mean age was 46.7 years, 51.8% were male, 22.9% had severe disease, and mortality was 5.6%. Underlying immunosuppression, diabetes, and malignancy were most strongly associated with severe COVID-19 (coefficient =  53.9, 23.4, 23.4, respectively, all P \u003C .0007), while older age, male gender, diabetes, and hypertension were also associated with higher mortality (coefficient = 0.05 per year, 5.1, 8.2, 6.99, respectively; P = .006-.0002). Gastrointestinal (nausea, vomiting, abdominal pain) and respiratory symptoms (shortness of breath, chest pain) were associated with severe COVID-19, while pneumonia and end-organ failure were associated with mortality. COVID-19 is associated with a severe disease course in about 23% and mortality in about 6% of infected persons. Individuals with comorbidities and clinical features associated with severity should be monitored closely, and preventive efforts should especially target those with diabetes, malignancy, and immunosuppression.",[130],"https:\u002F\u002Feuropepmc.org\u002Farticles\u002FPMC7436673",[1199],{"id":1200,"sortIndex":25,"researcher":24,"roles":1201,"affiliations":1202,"properties":1203,"displayName":1205,"givenName":24,"familyName":24},"6fa5f867-874f-4262-a2d4-76e81c6704d4",[],[],{"title":1204},{"EN":1205},"John Borghi",{"url":24,"publisher":1207,"properties":24},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1208,"slug":10,"properties":1209,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1214,"manageAffiliations":1223,"indexDatabases":1234,"url":90,"thumbnailPath":24,"statistic":1249,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1210,"eissn":1211,"issn":1212,"title":1213},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[1215,1219],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":1216,"label":1217,"description":1218,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":1220,"label":1221,"description":1222,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[1224,1229],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":1225,"slug":24,"properties":1226,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1228,"statistic":24},[],{"title":1227},{"EN":45},[],{"id":48,"createTime":24,"updateTime":24,"relativeEntities":1230,"slug":24,"properties":1231,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1233,"statistic":24},[],{"title":1232},{"EN":52},[],[1235,1242],{"id":56,"indexDatabase":1236,"url":69,"indexYears":24,"academicFieldIds":1241,"indexDatabaseRanking":24},{"id":58,"createTime":24,"updateTime":24,"relativeEntities":1237,"label":1238,"description":1239,"key":65,"publicationTags":1240,"standard":24},[],{"EN":61,"VI":61},{"EN":63,"VI":64},[67,68],[71],{"id":73,"indexDatabase":1243,"url":84,"indexYears":85,"academicFieldIds":1248,"indexDatabaseRanking":89},{"id":75,"createTime":24,"updateTime":24,"relativeEntities":1244,"label":1245,"description":1246,"key":81,"publicationTags":1247,"standard":24},[],{"EN":78,"VI":78},{"EN":78,"VI":80},[83],[87,88],{"impactFactor":25,"impactFactorByYear":1250,"i10Index":25,"i10IndexLast5Year":25,"totalPublication":93,"totalPublicationByYear":1251,"totalCitation":95,"totalCitationByYear":1252,"totalCitationPerPublication":95,"totalCitationPerPublicationByYear":1253,"hindexLast5Year":93,"hindex":93},{},{"2020":93},{"2020":95},{"2020":95},"2020-08-13",[67,89],{"id":1257,"createTime":1258,"updateTime":1259,"relativeEntities":1260,"slug":1261,"properties":1262,"entityType":125,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":1267,"translateLanguages":24,"viewCount":25,"primaryUrl":1268,"fullTextUrl":24,"authors":1269,"publicationType":542,"publisherRelationship":1295,"citationCount":24,"citationInfo":24,"publishDate":1343,"publishYear":1344,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":1345,"openAccess":24,"references":24,"isForceReanalyzing":669},"56e9e146-3a8e-4131-8f8a-1c7f07cbaf5d","2025-12-15T02:50:35.685+00:00","2026-01-13T04:33:48.861+00:00",[],"Detect-and-suppress-future-zoonotic-derived-outbreaks-A-lesson-from-the-last-two-decades",{"title":1263,"doi":1265},{"EN":1264},"Detect and suppress future zoonotic‐derived outbreaks: A lesson from the last two decades",{"VOID":1266},"10.1002\u002Fjmv.28530",[130],"https:\u002F\u002Fdoi.org\u002F10.1002\u002Fjmv.28530",[1270,1279,1287],{"id":1271,"sortIndex":25,"researcher":24,"roles":1272,"affiliations":1273,"properties":1274,"displayName":1278,"givenName":24,"familyName":24},"feb06d51-c8fb-4aa0-a9fa-06f13914f9fc",[],[],{"email":1275,"title":1277},{"VOID":1276},"",{"EN":1278},"Nguyen K. 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In this study, we aimed to explore the relationship between therapeutic effectiveness of remdesivir and complications of diabetes mellitus by observing the recovery period among diabetic and nondiabetic patients associated with COVID‐19 infection. A total of 850 COVID‐19 patients were recruited for this study, out of which 48% were diabetic and 52% were nondiabetics. The results of this study indicated that nondiabetic individuals administered with remdesivir recovered from COVID‐19 within 10 days showing a 95% confidence interval (\u003Cjats:italic>p \u003C\u002Fjats:italic>< 0.01), while the diabetic individuals recovered in 15 days. Nondiabetic patients administered with remdesivir exhibited higher chances of clinical improvement at 15th day than those who were associated with diabetes. Remdesivir administration improved the levels of various biochemical parameters, such as C‐reactive protein, lactate dehydrogenase, \u003Cjats:sc>d\u003C\u002Fjats:sc>‐Dimer, and ferritin both in diabetic and nondiabetic patients. However, a significant improvement (\u003Cjats:italic>p \u003C\u002Fjats:italic>< 0.01) was seen in the level of biochemical parameters among nondiabetic patients as compared to that of diabetic patients administered with remdesivir treatment. In the end, it was concluded that remdesivir could be considered as a possible therapeutic agent in the treatment of COVID‐19 both in diabetic and nondiabetic situations. 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the end of January to mid‐June 2004 (weeks 5–24) a hepatitis A virus (HAV) outbreak occurred among a homeless and drug user community in Rotterdam, The Netherlands. To prevent further spread of the virus within this group and to the general population, the Municipal Health Service of Rotterdam organized a mass vaccination campaign during which 83% (1,515\u002F1,800) of the homeless people were vaccinated. As part of a national HAV typing study, blood and\u002For fecal samples of 30 Rotterdam HAV IgM(+) patients who fell ill during the period of 1 September 2003–1 December 2004 were tested. The tests included RT‐PCR and sequencing at the VP3‐VP1 and VP1‐P2a regions of the HAV genome. It was found that 12 homeless people, one family member of a homeless person and two people without a known risk were infected with a unique subtype 3a strain. Four of the homeless patients became ill after vaccination and were probably infected at the time. This study shows that Dutch homeless people and drug users involved in HAV outbreaks should be offered HAV vaccine actively to prevent further spread of the infection. 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