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In vitro studies indicate that stimulatory effects of IGF-I may be exerted through augmentation of inflammatory cytokine production. To further explore the immunomodulatory effects of IGF-I through regulation of cytokine production, we tested the in vitro effects of IGF-I on the secretion of inflammatory T helper cell type 1 (Th1) and Th2 cytokines by human peripheral blood mononuclear cells (PBMC). To this end, PBMC were stimulated with the T cell mitogen phytohemagglutinin (PHA), and cytokines in the culture media were assessed after 18, 42, 66, and 80 h of culture. We found that IGF-I stimulated the secretion of the Th2 cytokine interleukin (IL)-10 by 40–70% in PHA-stimulated PBMC. In addition, we observed a small stimulatory effect (15%) on the secretion of another Th2 cytokine IL-4. The secretion of IL-2, IL-5, IL-6, interferon-γ, and the inflammatory cytokines IL-1β, IL-8, and tumor necrosis factor α was not or was hardly affected. IL-10 secretion was also stimulated in purified T cells, and we established that IGF-I also stimulated IL-10 mRNA expression by 100–150%. The monocyte-activating bacterial cell-wall product lipopolysaccharide induced IL-10 production in PBMC, but this was not affected by IGF-I. As IL-10 predominantly exerts anti-inflammatory actions and suppresses Th1-dependent immune responses, our results indicate that IGF-I may exert inhibitory actions on inflammatory and Th1-mediated cellular immune responses through stimulation of IL-10 production in T cells.\u003C\u002Fjats:p>",{"EN":273},"Insulin-like growth factor-I stimulates IL-10 production in human T cells",{"VOID":275},"15277570",{"VOID":277},"10.1189\u002Fjlb.0404248",[148],"https:\u002F\u002Facademic.oup.com\u002Fjleukbio\u002Farticle\u002F76\u002F4\u002F862\u002F6975996",[281,300],{"id":282,"sortIndex":191,"researcher":24,"roles":283,"affiliations":284,"properties":295},"53d0a12d-3ddd-4541-803c-618255cf165f",[],[285],{"id":286,"sortIndex":25,"affiliation":287,"properties":24},"8f66b035-14c8-4998-985a-3566fb11c1e9",{"id":288,"createTime":289,"updateTime":289,"relativeEntities":290,"slug":291,"properties":292,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"ac1f6d00-3bf3-4cee-8029-0aa95ac61b0e","2024-09-05T23:41:50.509+00:00",[],"Laboratory-for-Neuroendocrine-Immunology-Department-of-Pharmacology-Medical-School-Free-University-of-Brussels-VUB-Belgium",{"title":293},{"EN":294},"Laboratory for Neuroendocrine Immunology, Department of Pharmacology, Medical School, Free University of Brussels (VUB) , Belgium",{"openalex":296,"title":298},{"VOID":297},"A5058692266",{"EN":299},"Astrid Coppens",{"id":301,"sortIndex":25,"researcher":24,"roles":302,"affiliations":303,"properties":310},"dc40a075-c882-415a-93bf-f56d87482f9e",[],[304],{"id":305,"sortIndex":25,"affiliation":306,"properties":24},"d0d6712a-aa60-4eb2-a43b-e6091f0c9e7c",{"id":288,"createTime":289,"updateTime":289,"relativeEntities":307,"slug":291,"properties":308,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":309},{"EN":294},{"openalex":311,"orcid":313,"title":315},{"VOID":312},"A5072560534",{"VOID":314},"https:\u002F\u002Forcid.org\u002F0000-0002-3676-477X",{"EN":316},"Ron Kooijman",{"url":24,"publisher":318,"properties":343},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":319,"slug":10,"properties":320,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":326,"manageAffiliations":327,"indexDatabases":328,"url":118,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":321,"issn":322,"introduce":323,"eissn":324,"title":325},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[329,336],{"id":77,"indexDatabase":330,"url":92,"indexYears":24,"academicFieldIds":335,"indexDatabaseRanking":24},{"id":79,"createTime":80,"updateTime":81,"relativeEntities":331,"label":332,"description":333,"key":88,"publicationTags":334,"standard":24},[],{"EN":84,"VI":84},{"VI":86,"EN":87},[90,91],[94,95,96],{"id":98,"indexDatabase":337,"url":111,"indexYears":112,"academicFieldIds":342,"indexDatabaseRanking":117},{"id":100,"createTime":101,"updateTime":102,"relativeEntities":338,"label":339,"description":340,"key":108,"publicationTags":341,"standard":24},[],{"EN":105,"VI":105},{"EN":105,"VI":107},[110],[114,115,116],{"volume":344,"pages":346,"issue":348},{"VOID":345},"76",{"VOID":347},"862-867",{"VOID":349},"4",69,{"total":350,"publishYear":24,"statisticByYear":352},{"2012":353,"2013":153,"2014":62,"2015":191,"2016":62,"2017":354,"2018":355,"2020":355,"2021":62,"2022":62,"2023":153,"2024":62},3,5,6,"2004-07-26",2004,[359,363,367,371,375,379,383,387,391,395,399,403,407,411,415,419,423,427,431,435,439,443,447,451,454,458,462,466,470,473,476,480,484,488],{"id":24,"text":360,"url":24,"identifiers":361},"Kooijman, 2004, Immunoendocrinology in Health and Disease, 163, 10.1201\u002F9780203021941.ch9",{"doi":362},"10.1201\u002F9780203021941.ch9",{"id":24,"text":364,"url":24,"identifiers":365},"Kooijman, 1996, Prolactin, growth hormone and insulin-like growth factor-I in the immune system, Adv. Immunol., 63, 377, 10.1016\u002FS0065-2776(08)60860-3",{"doi":366},"10.1016\u002FS0065-2776(08)60860-3",{"id":24,"text":368,"url":24,"identifiers":369},"Clark, 1997, The somatogenic hormones and insulin-like growth factor-1: stimulators of lymphopoiesis and immune function, Endocr. 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Signal., 15, 1091, 10.1016\u002FS0898-6568(03)00069-X",{"doi":382},"10.1016\u002FS0898-6568(03)00069-X",{"id":24,"text":384,"url":24,"identifiers":385},"Che, 2002, Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-α-induced c-Jun and NF-κB activation and adhesion molecule expression, Circ. Res., 90, 1222, 10.1161\u002F01.RES.0000021127.83364.7D",{"doi":386},"10.1161\u002F01.RES.0000021127.83364.7D",{"id":24,"text":388,"url":24,"identifiers":389},"Fernandez, 2001, Exacerbated inflammatory response induced by insulin-like growth factor I treatment in rats with ischemic acute renal failure, J. Am. Soc. Nephrol., 12, 1900, 10.1681\u002FASN.V1291900",{"doi":390},"10.1681\u002FASN.V1291900",{"id":24,"text":392,"url":24,"identifiers":393},"Feterowski, 2001, Immune protection against septic peritonitis in endotoxin-primed mice is related to reduced neutrophil apoptosis, Eur. J. Immunol., 31, 1268, 10.1002\u002F1521-4141(200104)31:4\u003C1268::AID-IMMU1268>3.0.CO;2-C",{"doi":394},"10.1002\u002F1521-4141(200104)31:4\u003C1268::AID-IMMU1268>3.0.CO;2-C",{"id":24,"text":396,"url":24,"identifiers":397},"Inoue, 1995, Growth hormone and insulinlike growth factor I enhance host defense in a murine sepsis model, Arch. Surg., 130, 1115, 10.1001\u002Farchsurg.1995.01430100093018",{"doi":398},"10.1001\u002Farchsurg.1995.01430100093018",{"id":24,"text":400,"url":24,"identifiers":401},"Firth, 2002, Cellular actions of the insulin-like growth factor binding proteins, Endocr. Rev., 23, 824, 10.1210\u002Fer.2001-0033",{"doi":402},"10.1210\u002Fer.2001-0033",{"id":24,"text":404,"url":24,"identifiers":405},"Jeschke, 2000, Insulin-like growth factor I in combination with insulin-like growth factor binding protein 3 affects the hepatic acute phase response and hepatic morphology in thermally injured rats, Ann. Surg., 231, 408, 10.1097\u002F00000658-200003000-00014",{"doi":406},"10.1097\u002F00000658-200003000-00014",{"id":24,"text":408,"url":24,"identifiers":409},"Jeschke, 2000, Insulinlike growth factor I plus insulinlike growth factor binding protein 3 attenuates the proinflammatory acute phase response in severely burned children, Ann. Surg., 231, 246, 10.1097\u002F00000658-200002000-00014",{"doi":410},"10.1097\u002F00000658-200002000-00014",{"id":24,"text":412,"url":24,"identifiers":413},"Cohen, 2001, Clinical implications of the IGF-cancer connection, Growth Horm. IGF Res., 11, 336, 10.1054\u002Fghir.2001.0255",{"doi":414},"10.1054\u002Fghir.2001.0255",{"id":24,"text":416,"url":24,"identifiers":417},"Chen, 2004, Insulin-like growth factor (IGF)-I\u002FIGF-binding protein-3 complex: therapeutic efficacy and mechanism of protection against type 1 diabetes, Endocrinology, 145, 627, 10.1210\u002Fen.2003-1274",{"doi":418},"10.1210\u002Fen.2003-1274",{"id":24,"text":420,"url":24,"identifiers":421},"Liu, 1997, Insulin-like growth factor-I treatment reduces immune cell responses in acute non-demyelinative experimental autoimmune encephalomyelitis, J. Neurosci. Res., 47, 531, 10.1002\u002F(SICI)1097-4547(19970301)47:5\u003C531::AID-JNR8>3.0.CO;2-I",{"doi":422},"10.1002\u002F(SICI)1097-4547(19970301)47:5\u003C531::AID-JNR8>3.0.CO;2-I",{"id":24,"text":424,"url":24,"identifiers":425},"Lovett-Racke, 1998, Regulation of experimental autoimmune encephalomyelitis with insulin-like growth factor (IGF-1) and IGF-1\u002FIGF-binding protein-3 complex (IGF-1\u002FIGFBP3), J. Clin. Invest., 101, 1797, 10.1172\u002FJCI1486",{"doi":426},"10.1172\u002FJCI1486",{"id":24,"text":428,"url":24,"identifiers":429},"Tu, 1999, IGF-I increases interferon-γ and IL-6 mRNA expression and protein production in neonatal mononuclear cells, Pediatr. Res., 46, 748, 10.1203\u002F00006450-199912000-00019",{"doi":430},"10.1203\u002F00006450-199912000-00019",{"id":24,"text":432,"url":24,"identifiers":433},"Yang, 2002, The effects of antisense insulin-like growth factor-I receptor oligonucleotide on human cord blood lymphocytes, J. Mol. Endocrinol., 28, 207, 10.1677\u002Fjme.0.0280207",{"doi":434},"10.1677\u002Fjme.0.0280207",{"id":24,"text":436,"url":24,"identifiers":437},"Kooijman, 1996, IGF-I potentiates interleukin-2 production in human peripheral T cells, J. Endocrinol., 149, 351, 10.1677\u002Fjoe.0.1490351",{"doi":438},"10.1677\u002Fjoe.0.1490351",{"id":24,"text":440,"url":24,"identifiers":441},"Brocardo, 2001, Early effects of insulin-like growth factor-1 in activated human T lymphocytes, J. Leukoc. Biol., 70, 297, 10.1189\u002Fjlb.70.2.297",{"doi":442},"10.1189\u002Fjlb.70.2.297",{"id":24,"text":444,"url":24,"identifiers":445},"Moore, 2001, Interleukin-10 and the interleukin-10 receptor, Annu. Rev. Immunol., 19, 683, 10.1146\u002Fannurev.immunol.19.1.683",{"doi":446},"10.1146\u002Fannurev.immunol.19.1.683",{"id":24,"text":448,"url":24,"identifiers":449},"Berg, 1996, Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses, J. Clin. Invest., 98, 1010, 10.1172\u002FJCI118861",{"doi":450},"10.1172\u002FJCI118861",{"id":24,"text":452,"url":24,"identifiers":453},"Cavaillon, 2001, Pro- versus anti-inflammatory cytokines: myth or reality, Cell. Mol. Biol. (Noisy-Le-Grand), 47, 695",{},{"id":24,"text":455,"url":24,"identifiers":456},"Robbins, 1994, Immunological effects of insulin-like growth factor-I—enhancement of immunoglobulin synthesis, Clin. Exp. Immunol., 95, 337, 10.1111\u002Fj.1365-2249.1994.tb06534.x",{"doi":457},"10.1111\u002Fj.1365-2249.1994.tb06534.x",{"id":24,"text":459,"url":24,"identifiers":460},"Arkins, 1993, Murine macrophages express abundant insulin-like growth factor-I class I Ea and Eb transcripts, Endocrinology, 133, 2334, 10.1210\u002Fendo.133.5.8404686",{"doi":461},"10.1210\u002Fendo.133.5.8404686",{"id":24,"text":463,"url":24,"identifiers":464},"Kooijman, 1992, Effects of insulin-like growth factors and growth hormone on the in vitro proliferation of T lymphocytes, J. Neuroimmunol., 38, 95, 10.1016\u002F0165-5728(92)90094-2",{"doi":465},"10.1016\u002F0165-5728(92)90094-2",{"id":24,"text":467,"url":24,"identifiers":468},"Jeschke, 2002, IGF-I\u002FIGFBP-3 equilibrates ratios of pro- to anti-inflammatory cytokines, which are predictors for organ function in severely burned pediatric patients, Mol. Med., 8, 238, 10.1007\u002FBF03402149",{"doi":469},"10.1007\u002FBF03402149",{"id":24,"text":471,"url":24,"identifiers":472},"Warzecha, 2003, IGF-1 stimulates production of interleukin-10 and inhibits development of caerulein-induced pancreatitis, J. Physiol. Pharmacol., 54, 575",{},{"id":24,"text":474,"url":24,"identifiers":475},"Burtrum, 2003, A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo, Cancer Res., 63, 8912",{},{"id":24,"text":477,"url":24,"identifiers":478},"Matsuda, 1994, Interleukin 10 pretreatment protects target cells from tumor- and allo-specific cytotoxic T cells and downregulates HLA class I expression, J. Exp. Med., 180, 2371, 10.1084\u002Fjem.180.6.2371",{"doi":479},"10.1084\u002Fjem.180.6.2371",{"id":24,"text":481,"url":24,"identifiers":482},"Masood, 1995, Interleukin-10 is an autocrine growth factor for acquired immunodeficiency syndrome-related B-cell lymphoma, Blood, 85, 3423, 10.1182\u002Fblood.V85.12.3423.bloodjournal85123423",{"doi":483},"10.1182\u002Fblood.V85.12.3423.bloodjournal85123423",{"id":24,"text":485,"url":24,"identifiers":486},"Lazar-Molnar, 2000, Autocrine and paracrine regulation by cytokines and growth factors in melanoma, Cytokine, 12, 547, 10.1006\u002Fcyto.1999.0614",{"doi":487},"10.1006\u002Fcyto.1999.0614",{"id":24,"text":489,"url":24,"identifiers":490},"Otsuki, 2002, IL-10 in myeloma cells, Leuk. Lymphoma, 43, 969, 10.1080\u002F10428190290021579",{"doi":491},"10.1080\u002F10428190290021579",{"id":493,"createTime":494,"updateTime":494,"relativeEntities":495,"slug":496,"properties":497,"entityType":143,"verifyStatus":144,"verifyTime":494,"verifyNote":146,"syncStatus":23,"languages":511,"translateLanguages":24,"viewCount":25,"primaryUrl":512,"fullTextUrl":24,"authors":513,"publicationType":207,"publisherRelationship":546,"citationCount":579,"citationInfo":580,"publishDate":585,"publishYear":586,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":587,"isForceReanalyzing":258},"3aa70dd2-9bc4-4901-8f11-1baabfb3899e","2024-09-22T23:35:22.003+00:00",[],"A-leading-role-for-the-immune-system-in-the-pathophysiology-of-preeclampsia",{"mag":498,"keywords":500,"openalex":501,"abstract":503,"title":505,"pm":507,"doi":509},{"VOID":499},"2150693693",{},{"VOID":502},"W2150693693",{"EN":504},"\u003Cjats:title>ABSTRACT\u003C\u002Fjats:title>\u003Cjats:p>Preeclampsia syndrome is characterized by inadequate placentation, because of deficient trophoblastic invasion of the uterine spiral arteries, leading to placental hypoxia, secretion of proinflammatory cytokines, the release of angiogenic and antiangiogenic factors and miRNAs. Although immune-system alterations are associated with the origin of preeclampsia, other factors, including proinflammatory cytokines, neutrophil activation, and endothelial dysfunction, are also related to the pathophysiology of this syndrome. The pathophysiology of preeclampsia may involve several factors, including persistent hypoxia at the placental level and the release of high amounts of STBMs. DAMP molecules released under hypoxic conditions and STBMs, which bind TLRs, may activate monocytes, DCs, NK cells, and neutrophils, promoting persistent inflammatory conditions in this syndrome. The development of hypertension in preeclamptic women is also associated with endothelial dysfunction, which may be mediated by various mechanisms, including neutrophil activation and NET formation. Furthermore, preeclamptic women have higher levels of nonclassic and intermediate monocytes and lower levels of lymphoid BDCA-2+ DCs. The cytokines secreted by these cells may contribute to the inflammatory process and to changes in adaptive-immune system cells, which are also modulated in preeclampsia. The changes in T cell subsets that may be seen in preeclampsia include low Treg activity, a shift toward Th1 responses, and the presence of Th17 lymphocytes. B cells can participate in the pathophysiology of preeclampsia by producing autoantibodies against adrenoreceptors and autoantibodies that bind the AT1-R.\u003C\u002Fjats:p>",{"EN":506},"A leading role for the immune system in the pathophysiology of preeclampsia",{"VOID":508},"23633414",{"VOID":510},"10.1189\u002Fjlb.1112603",[148],"https:\u002F\u002Facademic.oup.com\u002Fjleukbio\u002Farticle\u002F94\u002F2\u002F247\u002F6959315",[514],{"id":515,"sortIndex":25,"researcher":24,"roles":516,"affiliations":517,"properties":539},"125b1174-2ccb-4780-8a0e-9458b90cb3ab",[],[518,528],{"id":519,"sortIndex":191,"affiliation":520,"properties":24},"b5edbc00-717e-4ab7-9b8c-0d269b2479da",{"id":521,"createTime":522,"updateTime":522,"relativeEntities":523,"slug":524,"properties":525,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"fb5c8fd9-c877-4415-8698-78609379bdf3","2024-09-22T23:35:22.029+00:00",[],"American-British-Cowdray-Medical-Center-Mexico-City-Mexico-and-Department-of-Immunology-School-of-Medicine-Universidad-Panamericana-Mexico-City-Mexico",{"title":526},{"EN":527},"American British Cowdray Medical Center, Mexico City, Mexico; and Department of Immunology, School of Medicine, Universidad Panamericana , Mexico City, Mexico",{"id":529,"sortIndex":25,"affiliation":530,"properties":24},"db12cdf2-0c89-433e-be7a-f81792373f08",{"id":531,"createTime":532,"updateTime":533,"relativeEntities":534,"slug":535,"properties":536,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"d2da9d04-1cb6-45bb-86af-01a561994ac7","2023-11-27T12:43:13.521+00:00","2024-09-22T23:35:22.026+00:00",[],"American-British-Cowdray-Medical-Center-Mexico-City-Mexico",{"title":537},{"VI":538},"American British Cowdray Medical Center, Mexico City, Mexico",{"openalex":540,"orcid":542,"title":544},{"VOID":541},"A5079794498",{"VOID":543},"https:\u002F\u002Forcid.org\u002F0000-0002-3271-9955",{"EN":545},"Estibalitz Laresgoiti‐Servitje",{"url":24,"publisher":547,"properties":572},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":548,"slug":10,"properties":549,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":555,"manageAffiliations":556,"indexDatabases":557,"url":118,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":550,"issn":551,"introduce":552,"eissn":553,"title":554},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[558,565],{"id":77,"indexDatabase":559,"url":92,"indexYears":24,"academicFieldIds":564,"indexDatabaseRanking":24},{"id":79,"createTime":80,"updateTime":81,"relativeEntities":560,"label":561,"description":562,"key":88,"publicationTags":563,"standard":24},[],{"EN":84,"VI":84},{"VI":86,"EN":87},[90,91],[94,95,96],{"id":98,"indexDatabase":566,"url":111,"indexYears":112,"academicFieldIds":571,"indexDatabaseRanking":117},{"id":100,"createTime":101,"updateTime":102,"relativeEntities":567,"label":568,"description":569,"key":108,"publicationTags":570,"standard":24},[],{"EN":105,"VI":105},{"EN":105,"VI":107},[110],[114,115,116],{"volume":573,"pages":575,"issue":577},{"VOID":574},"94",{"VOID":576},"247-257",{"VOID":578},"2",273,{"total":579,"publishYear":24,"statisticByYear":581},{"2013":153,"2014":249,"2015":582,"2016":582,"2017":245,"2018":583,"2019":244,"2020":251,"2021":584,"2022":251,"2023":251,"2024":252},29,30,26,"2013-04-30",2013,[588,592,596,600,604,608,611,615,619,623,627,631,635,639,643,647,651,655,658,662,666,670,674,678,682,686,690,694,698,702,706,709,713,717,721,725,729,733,737,741,745,749,753,757,761,765,768,772,776,780,784,788,792,796,800,804,808,812,816,820,824,828,832,836,840,844,847,851,855,859,863,867,871,875,878,882,886,890,894,898,902,905,909,913,916,920,924,928,932,936,940,944,948,952,956,960,964,968,972,976,980,984,988,992,996,1000,1003,1007,1011,1014,1018,1022,1026,1030,1034,1038,1042,1046,1050,1054,1058,1062,1066,1070,1074,1078,1082,1086,1090,1094,1098,1102,1106,1110,1114,1118,1122,1126,1130,1134,1138,1142,1146,1150,1154,1158,1162,1166,1170],{"id":24,"text":589,"url":24,"identifiers":590},"Davey, 1989, Classification of hypertensive disorders in pregnancy, Lancet, 334, 112, 10.1016\u002FS0140-6736(89)90360-7",{"doi":591},"10.1016\u002FS0140-6736(89)90360-7",{"id":24,"text":593,"url":24,"identifiers":594},"Chappell, 2008, Adverse perinatal outcomes and risk factors for preeclampsia in women with chronic hypertension: a prospective study, Hypertension, 51, 1002, 10.1161\u002FHYPERTENSIONAHA.107.107565",{"doi":595},"10.1161\u002FHYPERTENSIONAHA.107.107565",{"id":24,"text":597,"url":24,"identifiers":598},"James, 2005, Cytotrophoblast differentiation in the first trimester of pregnancy: evidence for separate progenitors of extravillous trophoblasts and syncytiotrophoblast, Reproduction, 130, 95, 10.1530\u002Frep.1.00723",{"doi":599},"10.1530\u002Frep.1.00723",{"id":24,"text":601,"url":24,"identifiers":602},"Roberts, 2005, Preeclampsia: recent insights, Hypertension, 46, 1243, 10.1161\u002F01.HYP.0000188408.49896.c5",{"doi":603},"10.1161\u002F01.HYP.0000188408.49896.c5",{"id":24,"text":605,"url":24,"identifiers":606},"Kaufmann, 2003, Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia, Biol. Reprod., 69, 1, 10.1095\u002Fbiolreprod.102.014977",{"doi":607},"10.1095\u002Fbiolreprod.102.014977",{"id":24,"text":609,"url":24,"identifiers":610},"Odegard, 2000, Preeclampsia and fetal growth, Obstet. Gynecol., 96, 950",{},{"id":24,"text":612,"url":24,"identifiers":613},"Rolfo, 2010, Abnormalities in oxygen sensing define early and late onset preeclampsia as distinct pathologies, PLoS ONE, 5, 13288, 10.1371\u002Fjournal.pone.0013288",{"doi":614},"10.1371\u002Fjournal.pone.0013288",{"id":24,"text":616,"url":24,"identifiers":617},"Laresgoiti-Servitje, 2010, An immunological insight into the origins of pre-eclampsia, Hum. Reprod. Update, 16, 510, 10.1093\u002Fhumupd\u002Fdmq007",{"doi":618},"10.1093\u002Fhumupd\u002Fdmq007",{"id":24,"text":620,"url":24,"identifiers":621},"Mellembakken, 2001, Chemokines and leukocyte activation in the fetal circulation during preeclampsia, Hypertension, 38, 394, 10.1161\u002F01.HYP.38.3.394",{"doi":622},"10.1161\u002F01.HYP.38.3.394",{"id":24,"text":624,"url":24,"identifiers":625},"Sargent, 2006, Immunoregulation in normal pregnancy and pre-eclampsia: an overview, Rep. BioMed. Online, 13, 680, 10.1016\u002FS1472-6483(10)60659-1",{"doi":626},"10.1016\u002FS1472-6483(10)60659-1",{"id":24,"text":628,"url":24,"identifiers":629},"Srinivas, 2009, Rethinking IUGR in preeclampsia: dependent or independent of maternal hypertension?, J. Perinatol., 29, 680, 10.1038\u002Fjp.2009.83",{"doi":630},"10.1038\u002Fjp.2009.83",{"id":24,"text":632,"url":24,"identifiers":633},"Van der Merwe, 2010, Are early and late preeclampsia distinct subclasses of the disease—what does the placenta reveal?, Hypertens. Pregnancy, 29, 457, 10.3109\u002F10641950903572282",{"doi":634},"10.3109\u002F10641950903572282",{"id":24,"text":636,"url":24,"identifiers":637},"Parrish, 2010, The effect of immune factors, tumor necrosis factor-α, and agonistic autoantibodies to the angiotensin II type I receptor on soluble fms-like tyrosine-1 and soluble endoglin production in response to hypertension during pregnancy, Am. J. Hypertens., 23, 911, 10.1038\u002Fajh.2010.70",{"doi":638},"10.1038\u002Fajh.2010.70",{"id":24,"text":640,"url":24,"identifiers":641},"Parrish, 2011, Hypertension in response to AT1-AA: role of reactive oxygen species in pregnancy-induced hypertension, Am. J. Hypertens., 24, 835, 10.1038\u002Fajh.2011.62",{"doi":642},"10.1038\u002Fajh.2011.62",{"id":24,"text":644,"url":24,"identifiers":645},"Sela, 2008, A novel human-specific soluble vascular endothelial growth factor receptor 1: cell type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia, Circ. Res., 102, 1566, 10.1161\u002FCIRCRESAHA.108.171504",{"doi":646},"10.1161\u002FCIRCRESAHA.108.171504",{"id":24,"text":648,"url":24,"identifiers":649},"Noack, 2011, miRNA expression profiling in formalin-fixed and paraffin-embedded placental tissue samples from pregnancies with severe preeclampsia, J. Perinat. Med., 39, 267, 10.1515\u002Fjpm.2011.012",{"doi":650},"10.1515\u002Fjpm.2011.012",{"id":24,"text":652,"url":24,"identifiers":653},"Zhang, 2009, MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT, Cell Cycle, 8, 756, 10.4161\u002Fcc.8.17.9387",{"doi":654},"10.4161\u002Fcc.8.17.9387",{"id":24,"text":656,"url":24,"identifiers":657},"Nevo, 2006, Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1, Am. J. Physiol., 291, R1085",{},{"id":24,"text":659,"url":24,"identifiers":660},"Levine, 2006, Soluble endoglin and other circulating antiangiogenic factors in preeclampsia, N. Engl. J. Med., 355, 992, 10.1056\u002FNEJMoa055352",{"doi":661},"10.1056\u002FNEJMoa055352",{"id":24,"text":663,"url":24,"identifiers":664},"Gould, 2010, Upregulation of urotensin II receptor in preeclampsia causes in vitro placental release of soluble vascular endothelial growth factor receptor 1 in hypoxia, Hypertension, 56, 172, 10.1161\u002FHYPERTENSIONAHA.110.152074",{"doi":665},"10.1161\u002FHYPERTENSIONAHA.110.152074",{"id":24,"text":667,"url":24,"identifiers":668},"Sela, 2011, Local retention versus systemic release of soluble VEGF receptor-1 are mediated by heparin-binding and regulated by heparanase, Circ. Res., 108, 1063, 10.1161\u002FCIRCRESAHA.110.239665",{"doi":669},"10.1161\u002FCIRCRESAHA.110.239665",{"id":24,"text":671,"url":24,"identifiers":672},"Maynard, 2003, Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia, J. Clin. Invest., 111, 649, 10.1172\u002FJCI17189",{"doi":673},"10.1172\u002FJCI17189",{"id":24,"text":675,"url":24,"identifiers":676},"Wang, 2009, Preeclampsia: the role of angiogenic factors in its pathogenesis, Physiology, 24, 147, 10.1152\u002Fphysiol.00043.2008",{"doi":677},"10.1152\u002Fphysiol.00043.2008",{"id":24,"text":679,"url":24,"identifiers":680},"Gu, 2008, Placental productions and expressions of soluble endoglin, soluble fms-like tyrosine kinase receptor-1, and placental growth factor in normal and preeclamptic pregnancies, J. Clin. Endocrinol. Metab., 93, 260, 10.1210\u002Fjc.2007-1550",{"doi":681},"10.1210\u002Fjc.2007-1550",{"id":24,"text":683,"url":24,"identifiers":684},"Fujita, 2010, Role of extracellular signal-regulated kinase and AKT cascades in regulating hypoxia-induced angiogenic factors produced by a trophoblast-derived cell line, J. Endocrinol., 206, 131, 10.1677\u002FJOE-10-0027",{"doi":685},"10.1677\u002FJOE-10-0027",{"id":24,"text":687,"url":24,"identifiers":688},"Jung, 2012, Secretion of soluble vascular endothelial growth factor receptor 1 (sVEGFR1\u002FsFlt1) requires Arf1, Arf6, and Rab11 GTPases, PLoS ONE, 7, 44572, 10.1371\u002Fjournal.pone.0044572",{"doi":689},"10.1371\u002Fjournal.pone.0044572",{"id":24,"text":691,"url":24,"identifiers":692},"Munaut, 2008, Hypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblast, Hum. Reprod., 23, 1407, 10.1093\u002Fhumrep\u002Fden114",{"doi":693},"10.1093\u002Fhumrep\u002Fden114",{"id":24,"text":695,"url":24,"identifiers":696},"Thomas, 2009, A recently evolved novel trophoblast-enriched secreted form of fms-Like tyrosine kinase-1 variant is up-regulated in hypoxia and preeclampsia, J. Clin. Endocrinol. Metab., 94, 2524, 10.1210\u002Fjc.2009-0017",{"doi":697},"10.1210\u002Fjc.2009-0017",{"id":24,"text":699,"url":24,"identifiers":700},"Levine, 2004, Circulating angiogenic factors and the risk of preeclampsia, N. Engl. J. Med., 350, 672, 10.1056\u002FNEJMoa031884",{"doi":701},"10.1056\u002FNEJMoa031884",{"id":24,"text":703,"url":24,"identifiers":704},"Herse, 2009, Prevalence of agonistic autoantibodies against the angiotensin II type 1 receptor and soluble fms-like tyrosine kinase 1 in a gestational age-matched case study, Hypertension, 53, 393, 10.1161\u002FHYPERTENSIONAHA.108.124115",{"doi":705},"10.1161\u002FHYPERTENSIONAHA.108.124115",{"id":24,"text":707,"url":24,"identifiers":708},"Murphy, 2013, Control of soluble fms-like tyrosine-1 (sFlt-1) production response to placental ischemia\u002Fhypoxia: role of tumor necrosis factor-α, Am. J. Physiol., 304, R130",{},{"id":24,"text":710,"url":24,"identifiers":711},"Zhou, 2008, Autoantibody from women with preeclampsia induces soluble Fms-Like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin\u002Fnuclear factor of activated T-cells signaling, Hypertension, 51, 1010, 10.1161\u002FHYPERTENSIONAHA.107.097790",{"doi":712},"10.1161\u002FHYPERTENSIONAHA.107.097790",{"id":24,"text":714,"url":24,"identifiers":715},"Irani, 2010, Autoantibody-mediated angiotensin receptor activation contributes to preeclampsia through tumor necrosis factor-α signaling, Hypertension, 55, 1246, 10.1161\u002FHYPERTENSIONAHA.110.150540",{"doi":716},"10.1161\u002FHYPERTENSIONAHA.110.150540",{"id":24,"text":718,"url":24,"identifiers":719},"Gilad, 2008, Serum microRNAs are promising novel biomarkers, PLoS ONE, 3, 3148, 10.1371\u002Fjournal.pone.0003148",{"doi":720},"10.1371\u002Fjournal.pone.0003148",{"id":24,"text":722,"url":24,"identifiers":723},"Hu, 2009, Differential expression of microRNAs in the placentae of Chinese patients with severe pre-eclampsia, Clin. Chem. Lab. Med., 47, 923, 10.1515\u002FCCLM.2009.228",{"doi":724},"10.1515\u002FCCLM.2009.228",{"id":24,"text":726,"url":24,"identifiers":727},"Pineles, 2007, Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia, Am. J. Obstet. Gynecol., 196, 10.1016\u002Fj.ajog.2007.01.008",{"doi":728},"10.1016\u002Fj.ajog.2007.01.008",{"id":24,"text":730,"url":24,"identifiers":731},"O'Neill, 2010, Outfoxing Foxo1 with miR-182, Nat. Immunol., 11, 983, 10.1038\u002Fni1110-983",{"doi":732},"10.1038\u002Fni1110-983",{"id":24,"text":734,"url":24,"identifiers":735},"Tang, 2013, MicroRNA-182 plays an onco-miRNA role in cervical cancer, Gynecol. Oncol., 129, 199, 10.1016\u002Fj.ygyno.2012.12.043",{"doi":736},"10.1016\u002Fj.ygyno.2012.12.043",{"id":24,"text":738,"url":24,"identifiers":739},"Zhang, 2012, Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease, J. Cell. Mol. Med., 16, 249, 10.1111\u002Fj.1582-4934.2011.01291.x",{"doi":740},"10.1111\u002Fj.1582-4934.2011.01291.x",{"id":24,"text":742,"url":24,"identifiers":743},"Zhang, 2010, MicroRNA-155 contributes to preeclampsia by down-regulating CYR61, Am. J. Obstet. Gynecol., 202, 466, 10.1016\u002Fj.ajog.2010.01.057",{"doi":744},"10.1016\u002Fj.ajog.2010.01.057",{"id":24,"text":746,"url":24,"identifiers":747},"Messerli, 2010, Feto-maternal interactions in pregnancies: placental microparticles activate peripheral blood monocytes, Placenta, 31, 106, 10.1016\u002Fj.placenta.2009.11.011",{"doi":748},"10.1016\u002Fj.placenta.2009.11.011",{"id":24,"text":750,"url":24,"identifiers":751},"Germain, 2007, Systemic inflammatory priming in normal pregnancy and preeclampsia: the role of circulating syncytiotrophoblast microparticles, J. Immunol., 178, 5949, 10.4049\u002Fjimmunol.178.9.5949",{"doi":752},"10.4049\u002Fjimmunol.178.9.5949",{"id":24,"text":754,"url":24,"identifiers":755},"Southcombe, 2011, The immunomodulatory role of syncytiotrophoblast microvesicles, PLoS ONE, 6, e20245, 10.1371\u002Fjournal.pone.0020245",{"doi":756},"10.1371\u002Fjournal.pone.0020245",{"id":24,"text":758,"url":24,"identifiers":759},"Guller, 2011, Protein composition of microparticles shed from human placenta during placental perfusion: potential role in angiogenesis and fibrinolysis in preeclampsia, Placenta, 32, 63, 10.1016\u002Fj.placenta.2010.10.011",{"doi":760},"10.1016\u002Fj.placenta.2010.10.011",{"id":24,"text":762,"url":24,"identifiers":763},"Lee, 2012, Systemic inflammatory stimulation by microparticles derived from hypoxic trophoblast as a model for inflammatory response in preeclampsia, Am. J. Obstet. Gynecol., 207, 337, 10.1016\u002Fj.ajog.2012.06.047",{"doi":764},"10.1016\u002Fj.ajog.2012.06.047",{"id":24,"text":766,"url":24,"identifiers":767},"Holder, 2012, Heightened pro-inflammatory effect of preeclamptic placental microvesicles on peripheral blood immune cells in humans, Biol. Reprod., 86, 101",{},{"id":24,"text":769,"url":24,"identifiers":770},"Von Dadelszen, 1999, Supernatants from co-cultured endothelial cells and syncytiotrophoblast microvillous membranes activate peripheral blood leukocytes in vitro, Hum. Reprod., 14, 919, 10.1093\u002Fhumrep\u002F14.4.919",{"doi":771},"10.1093\u002Fhumrep\u002F14.4.919",{"id":24,"text":773,"url":24,"identifiers":774},"Matzinger, 2002, The danger model: a renewed sense of self, Science, 296, 301, 10.1126\u002Fscience.1071059",{"doi":775},"10.1126\u002Fscience.1071059",{"id":24,"text":777,"url":24,"identifiers":778},"Bonney, 2007, Preeclampsia: a view through the danger model, J. Reprod. Immunol., 76, 68, 10.1016\u002Fj.jri.2007.03.006",{"doi":779},"10.1016\u002Fj.jri.2007.03.006",{"id":24,"text":781,"url":24,"identifiers":782},"Lotze, 2007, Damage associated molecular pattern molecules, Clin. Immunol., 124, 1, 10.1016\u002Fj.clim.2007.02.006",{"doi":783},"10.1016\u002Fj.clim.2007.02.006",{"id":24,"text":785,"url":24,"identifiers":786},"Yang, 2005, The cytokine activity of HMGB1, J. Leukoc. Biol., 78, 1, 10.1189\u002Fjlb.1104648",{"doi":787},"10.1189\u002Fjlb.1104648",{"id":24,"text":789,"url":24,"identifiers":790},"Schmidt, 2004, Serum S100B in pregnancy-related hypertensive disorders: a case-control study, Clin. Chem., 50, 435, 10.1373\u002Fclinchem.2003.027391",{"doi":791},"10.1373\u002Fclinchem.2003.027391",{"id":24,"text":793,"url":24,"identifiers":794},"Holmlund, 2007, The novel inflammatory cytokine high mobility group box protein 1 (HMGB1) is expressed by human term placenta, Immunology, 122, 430, 10.1111\u002Fj.1365-2567.2007.02662.x",{"doi":795},"10.1111\u002Fj.1365-2567.2007.02662.x",{"id":24,"text":797,"url":24,"identifiers":798},"Tskitishvili, 2006, S100B protein expression in the amnion and amniotic fluid in pregnancies complicated by pre-eclampsia, Mol. Hum. Reprod., 12, 755, 10.1093\u002Fmolehr\u002Fgal083",{"doi":799},"10.1093\u002Fmolehr\u002Fgal083",{"id":24,"text":801,"url":24,"identifiers":802},"Tskitishvili, 2010, Oxidative stress-induced S100B protein from placenta and amnion affects soluble endoglin release from endothelial cells, Mol. Hum. Reprod., 16, 188, 10.1093\u002Fmolehr\u002Fgap104",{"doi":803},"10.1093\u002Fmolehr\u002Fgap104",{"id":24,"text":805,"url":24,"identifiers":806},"Kim, 2005, Toll-like receptor 4: a potential link between “danger signals,” the innate immune system, and preeclampsia?, Am. J. Obstet. Gynecol., 193, 921, 10.1016\u002Fj.ajog.2005.07.076",{"doi":807},"10.1016\u002Fj.ajog.2005.07.076",{"id":24,"text":809,"url":24,"identifiers":810},"Pineda, 2011, Expression of Toll-like receptor TLR-2, TLR-3, TLR-4 and TLR-9 is increased in placentas from patients with preeclampsia, Arch. Med. Res., 42, 382, 10.1016\u002Fj.arcmed.2011.08.003",{"doi":811},"10.1016\u002Fj.arcmed.2011.08.003",{"id":24,"text":813,"url":24,"identifiers":814},"Chatterjee, 2011, Interleukin 10 deficiency exacerbates Toll-like receptor 3-induced preeclampsia-like symptoms in mice, Hypertension, 58, 489, 10.1161\u002FHYPERTENSIONAHA.111.172114",{"doi":815},"10.1161\u002FHYPERTENSIONAHA.111.172114",{"id":24,"text":817,"url":24,"identifiers":818},"Hennessy, 1999, A deficiency of placental IL-10 in preeclampsia, J. Immunol., 163, 3491, 10.4049\u002Fjimmunol.163.6.3491",{"doi":819},"10.4049\u002Fjimmunol.163.6.3491",{"id":24,"text":821,"url":24,"identifiers":822},"Chatterjee, 2012, Placental Toll-like receptor 3 and Toll-like receptor 7\u002F8 activation contributes to preeclampsia in humans and mice, PLoS ONE, 7, 41884, 10.1371\u002Fjournal.pone.0041884",{"doi":823},"10.1371\u002Fjournal.pone.0041884",{"id":24,"text":825,"url":24,"identifiers":826},"Scharfe-Nugent, 2012, TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia, J. Immunol., 188, 5706, 10.4049\u002Fjimmunol.1103454",{"doi":827},"10.4049\u002Fjimmunol.1103454",{"id":24,"text":829,"url":24,"identifiers":830},"Leung, 2001, Increased maternal plasma fetal DNA concentrations in women who eventually develop preeclampsia, Clin. Chem., 47, 137, 10.1093\u002Fclinchem\u002F47.1.137",{"doi":831},"10.1093\u002Fclinchem\u002F47.1.137",{"id":24,"text":833,"url":24,"identifiers":834},"Conde-Agudelo, 2008, Maternal infection and risk of preeclampsia: systematic review and metaanalysis, Am. J. Obstet. Gynecol., 198, 7, 10.1016\u002Fj.ajog.2007.07.040",{"doi":835},"10.1016\u002Fj.ajog.2007.07.040",{"id":24,"text":837,"url":24,"identifiers":838},"Kawai, 2009, The roles of TLRs, RLRs and NLRs in pathogen recognition, Int. Immunol., 21, 317, 10.1093\u002Fintimm\u002Fdxp017",{"doi":839},"10.1093\u002Fintimm\u002Fdxp017",{"id":24,"text":841,"url":24,"identifiers":842},"Vásárhelyi, 2006, Three mechanisms in the pathogenesis of pre-eclampsia sug gested by over-represented transcription factor-binding sites detected with comparative promoter analysis, Mol. Hum. Reprod., 12, 31, 10.1093\u002Fmolehr\u002Fgal001",{"doi":843},"10.1093\u002Fmolehr\u002Fgal001",{"id":24,"text":845,"url":24,"identifiers":846},"Li, 2002, NF-κB regulation in the immune system, Nat. Rev. Immunol., 2, 25",{},{"id":24,"text":848,"url":24,"identifiers":849},"Luppi, 2006, Preeclampsia activates circulating immune cells with engagement of the NF-κB pathway, Am. J. Reprod. Immunol., 56, 135, 10.1111\u002Fj.1600-0897.2006.00386.x",{"doi":850},"10.1111\u002Fj.1600-0897.2006.00386.x",{"id":24,"text":852,"url":24,"identifiers":853},"Vaughan, 2012, Activation of NF-κB in placentas of women with preeclampsia, Hypertens. Pregnancy, 31, 243, 10.3109\u002F10641955.2011.642436",{"doi":854},"10.3109\u002F10641955.2011.642436",{"id":24,"text":856,"url":24,"identifiers":857},"Kawai, 2007, Signaling to NF-κB by Toll-like receptors, Trends Mol. Med., 13, 460, 10.1016\u002Fj.molmed.2007.09.002",{"doi":858},"10.1016\u002Fj.molmed.2007.09.002",{"id":24,"text":860,"url":24,"identifiers":861},"Sykes, 2012, Changes in the Th1: Th2 cytokine bias in pregnancy and the effects of the anti-inflammatory cyclopentenone prostaglandin 15-deoxy-Δ(12,14)-prostaglandin J2, Mediators Inflamm., 2012, 416739, 10.1155\u002F2012\u002F416739",{"doi":862},"10.1155\u002F2012\u002F416739",{"id":24,"text":864,"url":24,"identifiers":865},"Gomez-Lopez, 2010, Invasion of the leukocytes into the fetal-maternal interface during pregnancy, J. Leukoc. Biol., 88, 625, 10.1189\u002Fjlb.1209796",{"doi":866},"10.1189\u002Fjlb.1209796",{"id":24,"text":868,"url":24,"identifiers":869},"Abrahams, 2005, A role for TLRs in the regulation of immune cell migration by first trimester trophoblast cells, J. Immunol., 175, 8096, 10.4049\u002Fjimmunol.175.12.8096",{"doi":870},"10.4049\u002Fjimmunol.175.12.8096",{"id":24,"text":872,"url":24,"identifiers":873},"Bowen, 2005, Hypoxia promotes interleukin-6 and -8 but reduces interleukin-10 production by placental trophoblast cells from preeclamptic pregnancies, J. Soc. Gynecol. Investig., 12, 428, 10.1016\u002Fj.jsgi.2005.04.001",{"doi":874},"10.1016\u002Fj.jsgi.2005.04.001",{"id":24,"text":876,"url":24,"identifiers":877},"Benyo, 2001, Expression of inflammatory cytokines in placentas from women with preeclampsia, J. Clin. Endocrinol. Metab., 86, 2505",{},{"id":24,"text":879,"url":24,"identifiers":880},"Luppi, 2006, Monocytes of preeclamptic women spontaneously synthesize pro-inflammatory cytokines, Clin. Immunol., 118, 268, 10.1016\u002Fj.clim.2005.11.001",{"doi":881},"10.1016\u002Fj.clim.2005.11.001",{"id":24,"text":883,"url":24,"identifiers":884},"Ziegler-Heitbrock, 2010, Nomenclature of monocytes and dendritic cells in blood, Blood, 116, e74, 10.1182\u002Fblood-2010-02-258558",{"doi":885},"10.1182\u002Fblood-2010-02-258558",{"id":24,"text":887,"url":24,"identifiers":888},"Melgert, 2012, Pregnancy and preeclampsia affect monocyte subsets in humans and rats, PLoS ONE, 7, 45229, 10.1371\u002Fjournal.pone.0045229",{"doi":889},"10.1371\u002Fjournal.pone.0045229",{"id":24,"text":891,"url":24,"identifiers":892},"Al-Ofi, 2012, Monocyte subpopulations from pre-eclamptic patients are abnormally skewed and exhibit exaggerated responses to Toll-like receptor ligands, PLoS ONE, 7, 42217, 10.1371\u002Fjournal.pone.0042217",{"doi":893},"10.1371\u002Fjournal.pone.0042217",{"id":24,"text":895,"url":24,"identifiers":896},"Zawada, 2011, SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset, Blood, 118, 10.1182\u002Fblood-2011-01-326827",{"doi":897},"10.1182\u002Fblood-2011-01-326827",{"id":24,"text":899,"url":24,"identifiers":900},"Ancuta, 2000, CD14+CD16++ cells derived in vitro from peripheral blood monocytes exhibit phenotypic and functional dendritic cell-like characteristics, Eur. J. Immunol., 30, 1872, 10.1002\u002F1521-4141(200007)30:7\u003C1872::AID-IMMU1872>3.0.CO;2-2",{"doi":901},"10.1002\u002F1521-4141(200007)30:7\u003C1872::AID-IMMU1872>3.0.CO;2-2",{"id":24,"text":903,"url":24,"identifiers":904},"Khalil, 2002, Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models, Am. J. Physiol., 283",{},{"id":24,"text":906,"url":24,"identifiers":907},"Vila, 2005, Cytokines and vascular reactivity in resistance arteries, Am. J. Physiol. Heart Circ. Physiol., 288, 10.1152\u002Fajpheart.00779.2004",{"doi":908},"10.1152\u002Fajpheart.00779.2004",{"id":24,"text":910,"url":24,"identifiers":911},"Greer, 1989, Neutrophil activation in pregnancy-induced hypertension, Br. J. Obstet. Gynaecol., 96, 978, 10.1111\u002Fj.1471-0528.1989.tb03358.x",{"doi":912},"10.1111\u002Fj.1471-0528.1989.tb03358.x",{"id":24,"text":914,"url":24,"identifiers":915},"Greer, 1991, Neutrophil activation is confined to the maternal circulation in pregnancy-induced hypertension, Obstet. Gynecol., 78, 28",{},{"id":24,"text":917,"url":24,"identifiers":918},"Butterworth, 1991, Immunocytochemical localization of neutrophil elastase in term placenta decidua and myometrium in pregnancy-induced hypertension, Br. J. Obstet. Gynaecol., 98, 929, 10.1111\u002Fj.1471-0528.1991.tb13516.x",{"doi":919},"10.1111\u002Fj.1471-0528.1991.tb13516.x",{"id":24,"text":921,"url":24,"identifiers":922},"Cadden, 2008, Neutrophils, but not lymphocytes or monocytes, infiltrate maternal systemic vasculature in women with preeclampsia, Hypertens. Pregnancy, 27, 396, 10.1080\u002F10641950801958067",{"doi":923},"10.1080\u002F10641950801958067",{"id":24,"text":925,"url":24,"identifiers":926},"Tsukimori, 2008, Neutrophil-derived reactive oxygen species can modulate neutrophil adhesion to endothelial cells in preeclampsia, Am. J. Hypertens., 21, 587, 10.1038\u002Fajh.2007.87",{"doi":927},"10.1038\u002Fajh.2007.87",{"id":24,"text":929,"url":24,"identifiers":930},"Quinn, 1995, Immunocytochemical detection of lipid peroxidation in phagosomes of human neutrophils: correlation with expression of flavocyto-chrome b, J. Leukoc. Biol., 57, 415, 10.1002\u002Fjlb.57.3.415",{"doi":931},"10.1002\u002Fjlb.57.3.415",{"id":24,"text":933,"url":24,"identifiers":934},"Barden, 2001, Study of plasma factors associated with neutrophil activation and lipid peroxidation in preeclampsia, Hypertension, 38, 803, 10.1161\u002Fhy1101.092969",{"doi":935},"10.1161\u002Fhy1101.092969",{"id":24,"text":937,"url":24,"identifiers":938},"Leik, 2004, Neutrophils infiltrate resistance-sized vessels of subcutaneous fat in women with preeclampsia, Hypertension, 44, 72, 10.1161\u002F01.HYP.0000130483.83154.37",{"doi":939},"10.1161\u002F01.HYP.0000130483.83154.37",{"id":24,"text":941,"url":24,"identifiers":942},"Gupta, 2005, Induction of neutrophil extracellular DNA lattices by placental microparticles and IL-8 and their presence in preeclampsia, Hum. Immunol., 66, 1146, 10.1016\u002Fj.humimm.2005.11.003",{"doi":943},"10.1016\u002Fj.humimm.2005.11.003",{"id":24,"text":945,"url":24,"identifiers":946},"Fuchs, 2007, Novel cell death program leads to neutrophil extracellular traps, J. Cell Biol., 176, 231, 10.1083\u002Fjcb.200606027",{"doi":947},"10.1083\u002Fjcb.200606027",{"id":24,"text":949,"url":24,"identifiers":950},"Kaplan, 2012, Neutrophil extracellular traps: doubleedged swords of innate immunity, J. Immunol., 189, 2689, 10.4049\u002Fjimmunol.1201719",{"doi":951},"10.4049\u002Fjimmunol.1201719",{"id":24,"text":953,"url":24,"identifiers":954},"Gupta, 2007, Neutrophil NETs: a novel contributor to preeclampsia-associated placental hypoxia?, Semin. Immunopathol., 29, 163, 10.1007\u002Fs00281-007-0073-4",{"doi":955},"10.1007\u002Fs00281-007-0073-4",{"id":24,"text":957,"url":24,"identifiers":958},"Saffarzadeh, 2012, Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones, PLoS ONE, 7, 32366, 10.1371\u002Fjournal.pone.0032366",{"doi":959},"10.1371\u002Fjournal.pone.0032366",{"id":24,"text":961,"url":24,"identifiers":962},"Remijsen, 2011, Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality, Cell Death Differ., 18, 581, 10.1038\u002Fcdd.2011.1",{"doi":963},"10.1038\u002Fcdd.2011.1",{"id":24,"text":965,"url":24,"identifiers":966},"Gandley, 2008, Increased myeloperoxidase in the placenta and circulation of women with preeclampsia, Hypertension, 52, 387, 10.1161\u002FHYPERTENSIONAHA.107.107532",{"doi":967},"10.1161\u002FHYPERTENSIONAHA.107.107532",{"id":24,"text":969,"url":24,"identifiers":970},"Guleria, 2007, Maternal acceptance of the fetus: true human tolerance, J. Immunol., 178, 3345, 10.4049\u002Fjimmunol.178.6.3345",{"doi":971},"10.4049\u002Fjimmunol.178.6.3345",{"id":24,"text":973,"url":24,"identifiers":974},"Lash, 2006, Interferon-γ inhibits extravillous trophoblast cell invasion by a mechanism that involves both changes in apoptosis and protease levels, FASEB J., 20, 2512, 10.1096\u002Ffj.06-6616com",{"doi":975},"10.1096\u002Ffj.06-6616com",{"id":24,"text":977,"url":24,"identifiers":978},"Molvarec, 2010, Decreased proportion of peripheral blood vascular endothelial growth factor-expressing T and natural killer cells in preeclampsia, Am. J. Obstet. Gynecol., 203, 567, 10.1016\u002Fj.ajog.2010.07.019",{"doi":979},"10.1016\u002Fj.ajog.2010.07.019",{"id":24,"text":981,"url":24,"identifiers":982},"Sivori, 2004, CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells, Proc. Natl. Acad. Sci. USA, 101, 10116, 10.1073\u002Fpnas.0403744101",{"doi":983},"10.1073\u002Fpnas.0403744101",{"id":24,"text":985,"url":24,"identifiers":986},"Hedlund, 2009, Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function, J. Immunol., 183, 340, 10.4049\u002Fjimmunol.0803477",{"doi":987},"10.4049\u002Fjimmunol.0803477",{"id":24,"text":989,"url":24,"identifiers":990},"Jurewicz, 2007, Human T and natural killer cells possess a functional renin-angiotensin system: further mechanisms of angiotensin II-induced inflammation, J. Am. Soc. Nephrol., 18, 1093, 10.1681\u002FASN.2006070707",{"doi":991},"10.1681\u002FASN.2006070707",{"id":24,"text":993,"url":24,"identifiers":994},"Herse, 2007, Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia, Hypertension, 49, 604, 10.1161\u002F01.HYP.0000257797.49289.71",{"doi":995},"10.1161\u002F01.HYP.0000257797.49289.71",{"id":24,"text":997,"url":24,"identifiers":998},"Blois, 2007, Dendritic cells: key to fetal tolerance?, Biol. Reprod., 77, 590, 10.1095\u002Fbiolreprod.107.060632",{"doi":999},"10.1095\u002Fbiolreprod.107.060632",{"id":24,"text":1001,"url":24,"identifiers":1002},"Steinman, 2006, Dendritic cells: translating innate to adaptive immunity, Curr. Top. Microbiol. Immunol., 311, 17",{},{"id":24,"text":1004,"url":24,"identifiers":1005},"Blois, 2005, Intercellular adhesion molecule-1\u002FLFA-1 cross talk is a proximate mediator capable of disrupting immune integration and tolerance mechanism at the feto-maternal interface in murine pregnancies, J. Immunol., 174, 1820, 10.4049\u002Fjimmunol.174.4.1820",{"doi":1006},"10.4049\u002Fjimmunol.174.4.1820",{"id":24,"text":1008,"url":24,"identifiers":1009},"Hsu, 2012, Altered decidual DC-SIGN+ antigen-presenting cells and impaired regulatory T-cell induction in preeclampsia, Am. J. Pathol., 181, 2149, 10.1016\u002Fj.ajpath.2012.08.032",{"doi":1010},"10.1016\u002Fj.ajpath.2012.08.032",{"id":24,"text":1012,"url":24,"identifiers":1013},"Kludka-Sternik, 2010, The expression of B7-H1 and B7-H4 molecules on immature myeloid and lymphoid dendritic cells in cord blood of healthy neonates, Folia Histochem. Cytobiol., 48, 658",{},{"id":24,"text":1015,"url":24,"identifiers":1016},"Darmochwal-Kolarz, 2003, Myeloid and lymphoid dendritic cells in normal pregnancy and pre-eclampsia, Clin. Exp. Immunol., 132, 339, 10.1046\u002Fj.1365-2249.2003.02136.x",{"doi":1017},"10.1046\u002Fj.1365-2249.2003.02136.x",{"id":24,"text":1019,"url":24,"identifiers":1020},"Leslie, 2002, CD1-mediated γ\u002Fδ T cell maturation of dendritic cells, J. Exp. Med., 196, 1575, 10.1084\u002Fjem.20021515",{"doi":1021},"10.1084\u002Fjem.20021515",{"id":24,"text":1023,"url":24,"identifiers":1024},"Banchereau, 2000, Immunobiology of dendritic cells, Annu. Rev. Immunol., 18, 767, 10.1146\u002Fannurev.immunol.18.1.767",{"doi":1025},"10.1146\u002Fannurev.immunol.18.1.767",{"id":24,"text":1027,"url":24,"identifiers":1028},"Schroder, 2010, A physiological function of inflammation-associated SerpinB2 is regulation of adaptive immunity, J. Immunol., 184, 2663, 10.4049\u002Fjimmunol.0902187",{"doi":1029},"10.4049\u002Fjimmunol.0902187",{"id":24,"text":1031,"url":24,"identifiers":1032},"Ohkuchi, 2001, Expansion of the fraction of Th1 cells in women with preeclampsia: inverse correlation between the percentage of Th1 cells and the plasma level of PAI-2, Am. J. Reprod. Immunol., 46, 252, 10.1034\u002Fj.1600-0897.2001.d01-10.x",{"doi":1033},"10.1034\u002Fj.1600-0897.2001.d01-10.x",{"id":24,"text":1035,"url":24,"identifiers":1036},"Jarrossay, 2001, Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells, Eur. J. Immunol., 31, 3388, 10.1002\u002F1521-4141(200111)31:11\u003C3388::AID-IMMU3388>3.0.CO;2-Q",{"doi":1037},"10.1002\u002F1521-4141(200111)31:11\u003C3388::AID-IMMU3388>3.0.CO;2-Q",{"id":24,"text":1039,"url":24,"identifiers":1040},"Panda, 2012, Dendritic cells in the circulation of women with preeclampsia demonstrate a pro-inflammatory bias secondary to dysregulation of TLR receptors, J. Reprod. Immunol., 94, 210, 10.1016\u002Fj.jri.2012.01.008",{"doi":1041},"10.1016\u002Fj.jri.2012.01.008",{"id":24,"text":1043,"url":24,"identifiers":1044},"Berghöfer, 2007, Natural and synthetic TLR7 ligands inhibit CpG-A- and CpG-C-oligodeoxynucleotide-induced IFN-α production, J. Immunol., 178, 4072, 10.4049\u002Fjimmunol.178.7.4072",{"doi":1045},"10.4049\u002Fjimmunol.178.7.4072",{"id":24,"text":1047,"url":24,"identifiers":1048},"Rutella, 2006, Tolerogenic dendritic cells: cytokine modulation comes of age, Blood, 108, 1435, 10.1182\u002Fblood-2006-03-006403",{"doi":1049},"10.1182\u002Fblood-2006-03-006403",{"id":24,"text":1051,"url":24,"identifiers":1052},"Muthuswamy, 2008, Ability of mature dendritic cells to interact with regulatory T cells is imprinted during maturation, Cancer Res., 68, 5972, 10.1158\u002F0008-5472.CAN-07-6818",{"doi":1053},"10.1158\u002F0008-5472.CAN-07-6818",{"id":24,"text":1055,"url":24,"identifiers":1056},"Verlohren, 2009, Immunology in hypertension, preeclampsia, and target-organ damage, Hypertension, 54, 439, 10.1161\u002FHYPERTENSIONAHA.108.120253",{"doi":1057},"10.1161\u002FHYPERTENSIONAHA.108.120253",{"id":24,"text":1059,"url":24,"identifiers":1060},"Banerjee, 2005, Placental expression of interferon-γ (IFN-γ) and its receptor IFN-γ R2 fail to switch from early hypoxic to late normotensive development in preeclampsia, J. Clin. Endocrinol. Metab., 90, 944, 10.1210\u002Fjc.2004-1113",{"doi":1061},"10.1210\u002Fjc.2004-1113",{"id":24,"text":1063,"url":24,"identifiers":1064},"Arriaga-Pizano, 2005, The predominant Th1 cytokine profile in maternal plasma of preeclamptic women is not reflected in the choriodecidual and fetal compartments, J. Soc. Gynecol. Invest., 12, 335, 10.1016\u002Fj.jsgi.2005.02.005",{"doi":1065},"10.1016\u002Fj.jsgi.2005.02.005",{"id":24,"text":1067,"url":24,"identifiers":1068},"Murphy, 2009, Interferon γ in successful pregnancies, Biol. Reprod., 80, 848, 10.1095\u002Fbiolreprod.108.073353",{"doi":1069},"10.1095\u002Fbiolreprod.108.073353",{"id":24,"text":1071,"url":24,"identifiers":1072},"Moreau, 1999, IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes, Int. Immunol., 11, 803, 10.1093\u002Fintimm\u002F11.5.803",{"doi":1073},"10.1093\u002Fintimm\u002F11.5.803",{"id":24,"text":1075,"url":24,"identifiers":1076},"Steinborn, 2012, Pregnancy-associated diseases are characterized by the composition of the systemic regulatory T cell (Treg) pool with distinct subsets of Tregs, Clin. Exp. Immunol., 167, 84, 10.1111\u002Fj.1365-2249.2011.04493.x",{"doi":1077},"10.1111\u002Fj.1365-2249.2011.04493.x",{"id":24,"text":1079,"url":24,"identifiers":1080},"Paeschke, 2005, Pre-eclampsia is not associated with changes in the levels of regulatory T cells in peripheral blood, Am. J. Reprod. Immunol., 54, 384, 10.1111\u002Fj.1600-0897.2005.00334.x",{"doi":1081},"10.1111\u002Fj.1600-0897.2005.00334.x",{"id":24,"text":1083,"url":24,"identifiers":1084},"Steinborn, 2008, Distinct subsets of regulatory T cells during pregnancy: is the imbalance of these subsets involved in the pathogenesis of preeclampsia?, Clin. Immunol., 129, 401, 10.1016\u002Fj.clim.2008.07.032",{"doi":1085},"10.1016\u002Fj.clim.2008.07.032",{"id":24,"text":1087,"url":24,"identifiers":1088},"Toldi, 2008, Decreased number of FoxP3+ regulatory T cells in preeclampsia, Acta Obstet. Gynecol. Scand., 87, 1229, 10.1080\u002F00016340802389470",{"doi":1089},"10.1080\u002F00016340802389470",{"id":24,"text":1091,"url":24,"identifiers":1092},"Darmochwal-Kolarz, 2012, The predominance of Th17 lymphocytes and decreased number and function of Treg cells in preeclampsia, J. Reprod. Immunol., 93, 75, 10.1016\u002Fj.jri.2012.01.006",{"doi":1093},"10.1016\u002Fj.jri.2012.01.006",{"id":24,"text":1095,"url":24,"identifiers":1096},"Saito, 2011, Clinical implication of recent advances in our understanding of IL-17 and reproductive immunology, Exp. Rev. Clin. Immunol., 7, 49, 10.1586\u002Feci.11.49",{"doi":1097},"10.1586\u002Feci.11.49",{"id":24,"text":1099,"url":24,"identifiers":1100},"Santner-Nanan, 2009, Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia, J. Immunol., 183, 7023, 10.4049\u002Fjimmunol.0901154",{"doi":1101},"10.4049\u002Fjimmunol.0901154",{"id":24,"text":1103,"url":24,"identifiers":1104},"Jianjun, 2010, Imbalance of T-cell transcription factors contributes to the Th1 type immunity predominant in pre-eclampsia, Am. J. Reprod. Immunol., 63, 38, 10.1111\u002Fj.1600-0897.2009.00763.x",{"doi":1105},"10.1111\u002Fj.1600-0897.2009.00763.x",{"id":24,"text":1107,"url":24,"identifiers":1108},"Saito, 2010, Th17 cells and regulatory T cells: new light on pathophysiology of preeclampsia, Immunol. Cell Biol., 88, 615, 10.1038\u002Ficb.2010.68",{"doi":1109},"10.1038\u002Ficb.2010.68",{"id":24,"text":1111,"url":24,"identifiers":1112},"Toldi, 2011, Increased prevalence of IL-17-producing peripheral blood lymphocytes in pre-eclampsia, Am. J. Reprod. Immunol., 66, 223, 10.1111\u002Fj.1600-0897.2011.00987.x",{"doi":1113},"10.1111\u002Fj.1600-0897.2011.00987.x",{"id":24,"text":1115,"url":24,"identifiers":1116},"Jensen, 2012, CD19 + CD5+ cells as indicators of preeclampsia, Hypertension, 59, 861, 10.1161\u002FHYPERTENSIONAHA.111.188276",{"doi":1117},"10.1161\u002FHYPERTENSIONAHA.111.188276",{"id":24,"text":1119,"url":24,"identifiers":1120},"Berland, 2002, Origins and functions of B-1 cells with notes on the role of CD5, Annu. Rev. Immunol., 20, 253, 10.1146\u002Fannurev.immunol.20.100301.064833",{"doi":1121},"10.1146\u002Fannurev.immunol.20.100301.064833",{"id":24,"text":1123,"url":24,"identifiers":1124},"Sato, 1996, CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity, J. Immunol., 157, 4371, 10.4049\u002Fjimmunol.157.10.4371",{"doi":1125},"10.4049\u002Fjimmunol.157.10.4371",{"id":24,"text":1127,"url":24,"identifiers":1128},"Vinuesa, 2009, Dysregulation of germinal centres in autoimmune disease, Nat. Rev. Immunol., 9, 45, 10.1038\u002Fnri2637",{"doi":1129},"10.1038\u002Fnri2637",{"id":24,"text":1131,"url":24,"identifiers":1132},"Ebeling, 1993, The majority of human tonsillar CD5+ B cells express somatically mutated V κ 4 genes, Eur. J. Immunol., 23, 1405, 10.1002\u002Feji.1830230636",{"doi":1133},"10.1002\u002Feji.1830230636",{"id":24,"text":1135,"url":24,"identifiers":1136},"Casali, 1987, Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu-1+ B-cell subset, Science, 236, 77, 10.1126\u002Fscience.3105056",{"doi":1137},"10.1126\u002Fscience.3105056",{"id":24,"text":1139,"url":24,"identifiers":1140},"Wallukat, 1999, Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor, J. Clin. Invest., 103, 945, 10.1172\u002FJCI4106",{"doi":1141},"10.1172\u002FJCI4106",{"id":24,"text":1143,"url":24,"identifiers":1144},"Siddiqui, 2010, Angiotensin receptor agonistic autoantibody is highly prevalent in preeclampsia: correlation with disease severity, Hypertension, 55, 386, 10.1161\u002FHYPERTENSIONAHA.109.140061",{"doi":1145},"10.1161\u002FHYPERTENSIONAHA.109.140061",{"id":24,"text":1147,"url":24,"identifiers":1148},"Dechend, 2006, Agonistic antibodies directed at the angiotensin II, AT1 receptor in preeclampsia, J. Soc. Gynecol. Investig., 13, 79, 10.1016\u002Fj.jsgi.2005.11.006",{"doi":1149},"10.1016\u002Fj.jsgi.2005.11.006",{"id":24,"text":1151,"url":24,"identifiers":1152},"Zhou, 2011, Autoantibody-mediated IL-6-dependent endothelin-1 elevation underlies pathogenesis in a mouse model of preeclampsia, J. Immunol., 186, 6024, 10.4049\u002Fjimmunol.1004026",{"doi":1153},"10.4049\u002Fjimmunol.1004026",{"id":24,"text":1155,"url":24,"identifiers":1156},"Yang, 2008, Autoantibody against AT1 receptor from preeclamptic patients induces vasoconstriction through angiotensin receptor activation, J. Hypertens., 26, 1629, 10.1097\u002FHJH.0b013e328304dbff",{"doi":1157},"10.1097\u002FHJH.0b013e328304dbff",{"id":24,"text":1159,"url":24,"identifiers":1160},"LaMarca, 2011, Hypertension in response to placental ischemia during pregnancy, Hypertension, 57, 865, 10.1161\u002FHYPERTENSIONAHA.110.167569",{"doi":1161},"10.1161\u002FHYPERTENSIONAHA.110.167569",{"id":24,"text":1163,"url":24,"identifiers":1164},"Irani, 2009, The detrimental role of angiotensin receptor agonistic autoantibodies in intrauterine growth restriction seen in preeclampsia, J. Exp. Med., 206, 2809, 10.1084\u002Fjem.20090872",{"doi":1165},"10.1084\u002Fjem.20090872",{"id":24,"text":1167,"url":24,"identifiers":1168},"Hubel, 2007, Agonistic angiotensin II type 1 receptor autoantibodies in postpartum women with a history of preeclampsia, Hypertension, 49, 612, 10.1161\u002F01.HYP.0000256565.20983.d4",{"doi":1169},"10.1161\u002F01.HYP.0000256565.20983.d4",{"id":24,"text":1171,"url":24,"identifiers":1172},"Ma, 2013, Association between the presence of autoantibodies against adrenoreceptors and severe pre-eclampsia: a pilot study, PLoS ONE, 8, 57983, 10.1371\u002Fjournal.pone.0057983",{"doi":1173},"10.1371\u002Fjournal.pone.0057983",{"id":1175,"createTime":1176,"updateTime":1176,"relativeEntities":1177,"slug":1178,"properties":1179,"entityType":143,"verifyStatus":144,"verifyTime":1176,"verifyNote":146,"syncStatus":23,"languages":1193,"translateLanguages":24,"viewCount":25,"primaryUrl":1194,"fullTextUrl":24,"authors":1195,"publicationType":207,"publisherRelationship":1235,"citationCount":1267,"citationInfo":1268,"publishDate":1276,"publishYear":1277,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1278,"isForceReanalyzing":258},"a3b0d327-b6a7-406b-acb9-0ea2260f642e","2024-09-25T23:24:22.589+00:00",[],"Requirement-for-STAT1-in-LPS-induced-gene-expression-in-macrophages",{"mag":1180,"keywords":1182,"openalex":1183,"abstract":1185,"title":1187,"pm":1189,"doi":1191},{"VOID":1181},"2126439584",{},{"VOID":1184},"W2126439584",{"EN":1186},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>This study examines the role of the signal transducer and activator of transcription 1 (STAT1) in induction of lipopolysaccharide (LPS)-stimulated gene expression both in vitro and in vivo. LPS-induced expression of an interferon (IFN)-inducible 10-kDa protein (IP-10), IFN regulatory factor-1 (IRF-1), and inducible nitric oxide synthase (iNOS) mRNAs was severely impaired in macrophages prepared fromStat1−\u002F− mice, whereas levels of tumor necrosis factor α and KC (a C-X-C chemokine) mRNA in LPS-treated cell cultures were unaffected. A similar deficiency in LPS-induced gene expression was observed in livers and spleens from Stat1−\u002F− mice. The reduced LPS-stimulated gene expression seen in Stat1−\u002F− macrophages was not the result of reduced activation of nuclear factor κB. LPS stimulated the delayed activation of both IFN-stimulated response element and IFN-γ-activated sequence binding activity in macrophages from wild-type mice. Activation of these STAT1-containing transcription factors was mediated by the intermediate induction of type I IFNs, since the LPS-induced IP-10, IRF-1, and iNOS mRNA expression was markedly reduced in macrophages fromIFN-α\u002FβR−\u002F− mice and blocked by cotreatment with antibodies against type I IFN. These results indicate that indirect activation of STAT1 by LPS-induced type I IFN participates in promoting optimal expression of LPS-inducible genes, and they suggest that STAT1 may play a critical role in innate immunity against gram-negative bacterial infection.\u003C\u002Fjats:p>",{"EN":1188},"Requirement for STAT1 in LPS-induced gene expression in macrophages",{"VOID":1190},"11310846",{"VOID":1192},"10.1189\u002Fjlb.69.4.598",[148],"https:\u002F\u002Facademic.oup.com\u002Fjleukbio\u002Farticle\u002F69\u002F4\u002F598\u002F6976673",[1196,1218],{"id":1197,"sortIndex":191,"researcher":24,"roles":1198,"affiliations":1199,"properties":1211},"2150ebd4-c04d-43d4-9b14-8045aa920fa3",[],[1200],{"id":1201,"sortIndex":25,"affiliation":1202,"properties":24},"ab53013e-d1ee-42b4-9974-ec7e4c51bf8f",{"id":1203,"createTime":1204,"updateTime":1205,"relativeEntities":1206,"slug":1207,"properties":1208,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"0a51e7b6-b99c-432f-8e3a-45f19e07ee0a","2024-01-19T00:34:28.559+00:00","2025-06-11T23:14:02.029+00:00",[],"Department-of-Immunology-Lerner-Research-Institute-Cleveland-Clinic-Foundation-Cleveland-Ohio",{"title":1209},{"VI":1210},"Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio",{"openalex":1212,"orcid":1214,"title":1216},{"VOID":1213},"A5011844060",{"VOID":1215},"https:\u002F\u002Forcid.org\u002F0000-0002-9817-242X",{"EN":1217},"Thomas A. Hamilton",{"id":1219,"sortIndex":25,"researcher":24,"roles":1220,"affiliations":1221,"properties":1228},"09e5faf4-aa28-40f9-a780-1edf846983ea",[],[1222],{"id":1223,"sortIndex":25,"affiliation":1224,"properties":24},"08bea0c7-3f3a-4337-aada-e8ff30147a8b",{"id":1203,"createTime":1204,"updateTime":1205,"relativeEntities":1225,"slug":1207,"properties":1226,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1227},{"VI":1210},{"openalex":1229,"orcid":1231,"title":1233},{"VOID":1230},"A5034838050",{"VOID":1232},"https:\u002F\u002Forcid.org\u002F0000-0002-6069-357X",{"EN":1234},"Yoshihiro Ohmori",{"url":24,"publisher":1236,"properties":1261},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1237,"slug":10,"properties":1238,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1244,"manageAffiliations":1245,"indexDatabases":1246,"url":118,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1239,"issn":1240,"introduce":1241,"eissn":1242,"title":1243},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1247,1254],{"id":77,"indexDatabase":1248,"url":92,"indexYears":24,"academicFieldIds":1253,"indexDatabaseRanking":24},{"id":79,"createTime":80,"updateTime":81,"relativeEntities":1249,"label":1250,"description":1251,"key":88,"publicationTags":1252,"standard":24},[],{"EN":84,"VI":84},{"VI":86,"EN":87},[90,91],[94,95,96],{"id":98,"indexDatabase":1255,"url":111,"indexYears":112,"academicFieldIds":1260,"indexDatabaseRanking":117},{"id":100,"createTime":101,"updateTime":102,"relativeEntities":1256,"label":1257,"description":1258,"key":108,"publicationTags":1259,"standard":24},[],{"EN":105,"VI":105},{"EN":105,"VI":107},[110],[114,115,116],{"volume":1262,"pages":1264,"issue":1266},{"VOID":1263},"69",{"VOID":1265},"598-604",{"VOID":349},257,{"total":1267,"publishYear":24,"statisticByYear":1269},{"2012":1270,"2013":1271,"2014":1272,"2015":1273,"2016":1270,"2017":1274,"2018":252,"2019":1275,"2020":1274,"2021":1271,"2022":1275,"2023":355,"2024":353},11,12,19,14,15,9,"2001-04-01",2001,[1279,1283,1286,1290,1294,1298,1302,1306,1310,1314,1317,1321,1325,1329,1333,1337,1340,1344,1348,1352,1356,1359,1363,1367,1371,1375,1379,1383,1387,1391,1395,1399,1403,1407,1411,1415,1418,1421,1425,1429,1433,1437,1441,1445,1449,1453,1456,1460,1464,1468,1472,1476],{"id":24,"text":1280,"url":24,"identifiers":1281},"Adams, 1984, The cell biology of macrophage activation, Annu. Rev. Immunol., 2, 283, 10.1146\u002Fannurev.iy.02.040184.001435",{"doi":1282},"10.1146\u002Fannurev.iy.02.040184.001435",{"id":24,"text":1284,"url":24,"identifiers":1285},"Hamilton, 1995, Signal Transduction in Leukocytes : Role of G-Protein Related and Other Pathways, 325",{},{"id":24,"text":1287,"url":24,"identifiers":1288},"Ulevitch, 1995, Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin, Annu. Rev. Immunol., 13, 437, 10.1146\u002Fannurev.iy.13.040195.002253",{"doi":1289},"10.1146\u002Fannurev.iy.13.040195.002253",{"id":24,"text":1291,"url":24,"identifiers":1292},"Sweet, 1996, Endotoxin signal transduction in macrophages, J. Leukoc. Biol., 60, 8, 10.1002\u002Fjlb.60.1.8",{"doi":1293},"10.1002\u002Fjlb.60.1.8",{"id":24,"text":1295,"url":24,"identifiers":1296},"Poltorak, 1998, Defective LPS signaling in C3H\u002FHeJ and C57BL\u002F10ScCr mice: mutations in Tlr4 gene, Science, 282, 2085, 10.1126\u002Fscience.282.5396.2085",{"doi":1297},"10.1126\u002Fscience.282.5396.2085",{"id":24,"text":1299,"url":24,"identifiers":1300},"Qureshi, 1999, Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4), J. Exp. Med., 189, 615, 10.1084\u002Fjem.189.4.615",{"doi":1301},"10.1084\u002Fjem.189.4.615",{"id":24,"text":1303,"url":24,"identifiers":1304},"Hoshino, 1999, Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the LPS gene product, J. Immunol., 162, 3749, 10.4049\u002Fjimmunol.162.7.3749",{"doi":1305},"10.4049\u002Fjimmunol.162.7.3749",{"id":24,"text":1307,"url":24,"identifiers":1308},"Medzhitov, 1998, MyD88 is an adaptor protein in the hToll\u002FIL-1 receptor family signaling pathways, Mol. Cell, 2, 253, 10.1016\u002FS1097-2765(00)80136-7",{"doi":1309},"10.1016\u002FS1097-2765(00)80136-7",{"id":24,"text":1311,"url":24,"identifiers":1312},"Baeuerle, 1994, Function and activation of NF-κB in the immune system, Annu. Rev. Immunol., 12, 141, 10.1146\u002Fannurev.iy.12.040194.001041",{"doi":1313},"10.1146\u002Fannurev.iy.12.040194.001041",{"id":24,"text":1315,"url":24,"identifiers":1316},"Karin, 1998, The NF-κB activation pathway: its regulation and role in inflammation and cell survival, Cancer. J. Sci. Am., 4, S92",{},{"id":24,"text":1318,"url":24,"identifiers":1319},"Ohmori, 1994, kB binding activity in a murine macrophage-like cell line: sequence-specific differences in kB binding and transcriptional activation functions, J. Biol. Chem., 269, 17684, 10.1016\u002FS0021-9258(17)32495-X",{"doi":1320},"10.1016\u002FS0021-9258(17)32495-X",{"id":24,"text":1322,"url":24,"identifiers":1323},"Matsusaka, 1993, Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc. Natl. Acad. Sci, USA, 90, 10193, 10.1073\u002Fpnas.90.21.10193",{"doi":1324},"10.1073\u002Fpnas.90.21.10193",{"id":24,"text":1326,"url":24,"identifiers":1327},"Ohmori, 1997, Synergy between interferon-γ and tumor necrosis factor-α in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kB, J. Biol. Chem., 272, 14899, 10.1074\u002Fjbc.272.23.14899",{"doi":1328},"10.1074\u002Fjbc.272.23.14899",{"id":24,"text":1330,"url":24,"identifiers":1331},"Lodie, 1997, Stimulation of macrophages by lipopolysaccharide alters the phosphorylation state, conformation, and function of PU.1 via activation of casein kinase II, J. Immunol., 158, 1848, 10.4049\u002Fjimmunol.158.4.1848",{"doi":1332},"10.4049\u002Fjimmunol.158.4.1848",{"id":24,"text":1334,"url":24,"identifiers":1335},"Kovarik, 1998, Stat1 combines signals derived from IFN-γ and LPS receptors during macrophage activation, EMBO. J., 17, 3660, 10.1093\u002Femboj\u002F17.13.3660",{"doi":1336},"10.1093\u002Femboj\u002F17.13.3660",{"id":24,"text":1338,"url":24,"identifiers":1339},"Fujihara, 1994, Role of endogenous interferon-beta in lipopolysaccharide-triggered activation of the inducible nitric-oxide synthase gene in a mouse macrophage cell line, J774. J. Biol, Chem., 269, 12773",{},{"id":24,"text":1341,"url":24,"identifiers":1342},"de Waal Malefyt, 1991, Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes, J. Exp. Med., 174, 1209, 10.1084\u002Fjem.174.5.1209",{"doi":1343},"10.1084\u002Fjem.174.5.1209",{"id":24,"text":1345,"url":24,"identifiers":1346},"Darnell, 1994, Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins, Science, 264, 1415, 10.1126\u002Fscience.8197455",{"doi":1347},"10.1126\u002Fscience.8197455",{"id":24,"text":1349,"url":24,"identifiers":1350},"Meraz, 1996, Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway, Cell, 84, 431, 10.1016\u002FS0092-8674(00)81288-X",{"doi":1351},"10.1016\u002FS0092-8674(00)81288-X",{"id":24,"text":1353,"url":24,"identifiers":1354},"Durbin, 1996, Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease, Cell, 84, 443, 10.1016\u002FS0092-8674(00)81289-1",{"doi":1355},"10.1016\u002FS0092-8674(00)81289-1",{"id":24,"text":1357,"url":24,"identifiers":1358},"Tsukada, 1996, A novel STAT-like factor mediates lipopolysaccharide, interleukin 1 (IL-1), and IL-6 signaling and recognizes a gamma interferon activation site-like element in the IL1B gene. Mol. Cell, Biol., 16, 2183",{},{"id":24,"text":1360,"url":24,"identifiers":1361},"Ruff-Jamison, 1994, Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver, J. Biol. Chem., 269, 21933, 10.1016\u002FS0021-9258(17)31735-0",{"doi":1362},"10.1016\u002FS0021-9258(17)31735-0",{"id":24,"text":1364,"url":24,"identifiers":1365},"Deng, 1996, LPS does not directly induce STAT activity in mouse macrophages, Cell. Immunol., 170, 20, 10.1006\u002Fcimm.1996.0129",{"doi":1366},"10.1006\u002Fcimm.1996.0129",{"id":24,"text":1368,"url":24,"identifiers":1369},"Yamaoka, 1998, Activation of STAT5 by lipopolysaccharide through granulocyte-macrophage colony-stimulating factor production in human monocytes, J. Immunol., 160, 838, 10.4049\u002Fjimmunol.160.2.838",{"doi":1370},"10.4049\u002Fjimmunol.160.2.838",{"id":24,"text":1372,"url":24,"identifiers":1373},"Gao, 1998, Autocrine\u002Fparacrine IFN-αβ mediates the lipopolysaccharide-induced activation of transcription factor Stat1α in mouse macrophages: pivotal role of Stat1a in induction of the inducible nitric oxide synthase gene. J, Immunol., 161, 4803, 10.4049\u002Fjimmunol.161.9.4803",{"doi":1374},"10.4049\u002Fjimmunol.161.9.4803",{"id":24,"text":1376,"url":24,"identifiers":1377},"Gessani, 1989, Bacterial lipopolysaccharide and gamma interferon induce transcription of beta interferon mRNA and interferon secretion in murine macrophages, J. Virol., 63, 2785, 10.1128\u002Fjvi.63.6.2785-2789.1989",{"doi":1378},"10.1128\u002Fjvi.63.6.2785-2789.1989",{"id":24,"text":1380,"url":24,"identifiers":1381},"Trinchieri, 1996, Immunoregulation by interleukin-12, J. Leukoc. Biol., 59, 505, 10.1002\u002Fjlb.59.4.505",{"doi":1382},"10.1002\u002Fjlb.59.4.505",{"id":24,"text":1384,"url":24,"identifiers":1385},"Muller, 1994, Functional role of type I and type II interferons in antiviral defense, Science, 264, 1918, 10.1126\u002Fscience.8009221",{"doi":1386},"10.1126\u002Fscience.8009221",{"id":24,"text":1388,"url":24,"identifiers":1389},"Ohmori, 1994, IFN-gamma selectively inhibits lipopolysaccharide-inducible JE\u002Fmonocyte chemoattractant protein-1 and KC\u002FGRO\u002Fmelanoma growth-stimulating activity gene expression in mouse peritoneal macrophages. J, Immunol., 153, 2204, 10.4049\u002Fjimmunol.153.5.2204",{"doi":1390},"10.4049\u002Fjimmunol.153.5.2204",{"id":24,"text":1392,"url":24,"identifiers":1393},"Chirgwin, 1979, Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease, Biochemistry, 18, 5294, 10.1021\u002Fbi00591a005",{"doi":1394},"10.1021\u002Fbi00591a005",{"id":24,"text":1396,"url":24,"identifiers":1397},"Ohmori, 1990, A macrophage LPS-inducible early gene encodes the murine homologue of IP-10, Biochem. Biophys. Res. Commun., 168, 1261, 10.1016\u002F0006-291X(90)91164-N",{"doi":1398},"10.1016\u002F0006-291X(90)91164-N",{"id":24,"text":1400,"url":24,"identifiers":1401},"Deng, 1993, Synergistic cooperation between T cell lymphokines for induction of the nitric oxide synthase gene in murine peritoneal macrophages, J. Immunol., 151, 322, 10.4049\u002Fjimmunol.151.1.322",{"doi":1402},"10.4049\u002Fjimmunol.151.1.322",{"id":24,"text":1404,"url":24,"identifiers":1405},"Higashi, 1983, Structure and expression of a cloned cDNA for mouse interferon-beta, J. Biol. Chem., 258, 9522, 10.1016\u002FS0021-9258(17)44698-9",{"doi":1406},"10.1016\u002FS0021-9258(17)44698-9",{"id":24,"text":1408,"url":24,"identifiers":1409},"Dignam, 1983, Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei, Nucleic Acids Res., 11, 1475, 10.1093\u002Fnar\u002F11.5.1475",{"doi":1410},"10.1093\u002Fnar\u002F11.5.1475",{"id":24,"text":1412,"url":24,"identifiers":1413},"Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem., 72, 248, 10.1016\u002F0003-2697(76)90527-3",{"doi":1414},"10.1016\u002F0003-2697(76)90527-3",{"id":24,"text":1416,"url":24,"identifiers":1417},"Ohmori, 1993, Cooperative interaction between interferon (IFN) stimulus response element and κB sequence motifs controls IFN γ- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter. J. Biol, Chem., 268, 6677",{},{"id":24,"text":1419,"url":24,"identifiers":1420},"Sims, 1993, A novel interferon-inducible domain: structural and functional analysis of the human interferon regulatory factor 1 gene promoter, Mol. Cell. Biol., 13, 690",{},{"id":24,"text":1422,"url":24,"identifiers":1423},"Muller, 1993, Nuclear factor kappa B, a mediator of lipopolysaccharide effects, Immunobiology, 187, 233, 10.1016\u002FS0171-2985(11)80342-6",{"doi":1424},"10.1016\u002FS0171-2985(11)80342-6",{"id":24,"text":1426,"url":24,"identifiers":1427},"Pine, 1997, Convergence of TNFa and IFNγ signalling pathways through synergistic induction of IRF-1\u002FISGF-2 is mediated by a composite GAS\u002FkB promoter element, Nucleic. Acids. Res., 25, 4346, 10.1093\u002Fnar\u002F25.21.4346",{"doi":1428},"10.1093\u002Fnar\u002F25.21.4346",{"id":24,"text":1430,"url":24,"identifiers":1431},"Lowenstein, 1993, Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide, Proc. Natl. Acad. Sci. USA, 90, 9730, 10.1073\u002Fpnas.90.20.9730",{"doi":1432},"10.1073\u002Fpnas.90.20.9730",{"id":24,"text":1434,"url":24,"identifiers":1435},"Xie, 1994, Role of transcription factor NF-KB\u002FRel in induction of nitric oxide synthase, J. Biol. Chem., 269, 4705, 10.1016\u002FS0021-9258(17)37600-7",{"doi":1436},"10.1016\u002FS0021-9258(17)37600-7",{"id":24,"text":1438,"url":24,"identifiers":1439},"Ohmori, 1995, The interferon-stimulated response element and a kB site mediate synergistic induction of murine IP-10 gene transcription by IFN-γ and TNF-α, J. Immunol., 154, 5235, 10.4049\u002Fjimmunol.154.10.5235",{"doi":1440},"10.4049\u002Fjimmunol.154.10.5235",{"id":24,"text":1442,"url":24,"identifiers":1443},"Fu, 1990, ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains, Proc. Natl. Acad. Sci. USA, 87, 8555, 10.1073\u002Fpnas.87.21.8555",{"doi":1444},"10.1073\u002Fpnas.87.21.8555",{"id":24,"text":1446,"url":24,"identifiers":1447},"Fu, 1992, The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction, Proc. Natl. Acad. Sci. USA, 89, 7840, 10.1073\u002Fpnas.89.16.7840",{"doi":1448},"10.1073\u002Fpnas.89.16.7840",{"id":24,"text":1450,"url":24,"identifiers":1451},"Cho, 1996, Activation of STAT4 by IL-12 and IFN-α: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation, J. Immunol., 157, 4781, 10.4049\u002Fjimmunol.157.11.4781",{"doi":1452},"10.4049\u002Fjimmunol.157.11.4781",{"id":24,"text":1454,"url":24,"identifiers":1455},"Rani, 1999, Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase. J. Biol, Chem., 274, 32507",{},{"id":24,"text":1457,"url":24,"identifiers":1458},"Jahnke, 1994, Synergistic activation of intercellular adhesion molecule 1 (ICAM-1) by TNF-α and IFN-γ is mediated by p65\u002Fp50 and p65\u002Fc-Rel and interferon-responsive factor Stat1-a (p91) that can be activated by both IFN-γ and IFN-α, FEBS Lett., 354, 220, 10.1016\u002F0014-5793(94)01130-3",{"doi":1459},"10.1016\u002F0014-5793(94)01130-3",{"id":24,"text":1461,"url":24,"identifiers":1462},"Kamijo, 1994, Requirement for transcription factor IRF-1 in NO synthase induction in macrophages, Science, 263, 1612, 10.1126\u002Fscience.7510419",{"doi":1463},"10.1126\u002Fscience.7510419",{"id":24,"text":1465,"url":24,"identifiers":1466},"Gao, 1997, An interferon-gamma-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharide, J. Biol. Chem., 272, 1226, 10.1074\u002Fjbc.272.2.1226",{"doi":1467},"10.1074\u002Fjbc.272.2.1226",{"id":24,"text":1469,"url":24,"identifiers":1470},"Cousens, 1997, Interferon-α\u002Fβ inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection, Proc. Natl. Acad. Sci. USA, 94, 634, 10.1073\u002Fpnas.94.2.634",{"doi":1471},"10.1073\u002Fpnas.94.2.634",{"id":24,"text":1473,"url":24,"identifiers":1474},"Faure, 1997, Inhibition of inducible nitric oxide synthase expression by interferons alpha and beta in bovine retinal pigmented epithelial cells, J. Biol. Chem., 272, 32169, 10.1074\u002Fjbc.272.51.32169",{"doi":1475},"10.1074\u002Fjbc.272.51.32169",{"id":24,"text":1477,"url":24,"identifiers":1478},"Lopez-Collazo, 1998, Triggering of peritoneal macrophages with IFN-α\u002Fβ attenuates the expression of inducible nitric oxide synthase through a decrease in NF-κB activation. J, Immunol., 160, 2889, 10.4049\u002Fjimmunol.160.6.2889",{"doi":1479},"10.4049\u002Fjimmunol.160.6.2889",{"id":1481,"createTime":1482,"updateTime":1482,"relativeEntities":1483,"slug":1484,"properties":1485,"entityType":143,"verifyStatus":144,"verifyTime":1482,"verifyNote":146,"syncStatus":23,"languages":1499,"translateLanguages":24,"viewCount":25,"primaryUrl":1500,"fullTextUrl":24,"authors":1501,"publicationType":207,"publisherRelationship":1623,"citationCount":246,"citationInfo":1655,"publishDate":1657,"publishYear":1658,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1659,"isForceReanalyzing":258},"470eb4c7-7d31-405b-8328-370612bfe5d8","2024-09-22T23:21:29.767+00:00",[],"Fibronectin-and-Complement-Secretion-By-Monocytes-and-Peritoneal-Macrophages-In-Vitro-From-Patients-Undergoing-Continuous-Ambulatory-Peritoneal-Dialysis",{"mag":1486,"keywords":1488,"openalex":1489,"abstract":1491,"title":1493,"pm":1495,"doi":1497},{"VOID":1487},"2186885808",{},{"VOID":1490},"W2186885808",{"EN":1492},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:p>We investigated the role of the opsonic glycoprotein fibronectin in the host defense of the peritoneum in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Fibronectin concentration in peritoneal dialysate from hight infection rate CAPD patients (>1.50 episodes peritonitis per year) was significantly less than from low infection rate CAPD patients (<0.55 episodes peritonitis per year). In vitro secretion of fibronectin by cultured peritoneal macrophages from patients with high infection rate was less than from low infection rate patients (P < 0.05) and controls (P < 0.01). In vitro secretion of the second component of complement, however, was similar in both high and low infection rate patients. Plasma fibronectin concentration and in vitro fibronectin secretion by cultured peripheral blood monocytes was not different between high infection rate patients and low infection rate patients, but was less than normals. Decreased fibronectin secretion by peritoneal macrophages is associated with a higher incidence of peritonitis among CAPD patients.\u003C\u002Fjats:p>",{"EN":1494},"Fibronectin and Complement Secretion By Monocytes and Peritoneal Macrophages In Vitro From Patients Undergoing Continuous Ambulatory Peritoneal Dialysis",{"VOID":1496},"3456405",{"VOID":1498},"10.1002\u002Fjlb.39.4.457",[148],"https:\u002F\u002Facademic.oup.com\u002Fjleukbio\u002Farticle\u002F39\u002F4\u002F457\u002F6978121",[1502,1521,1540,1555,1570,1589,1606],{"id":1503,"sortIndex":25,"researcher":24,"roles":1504,"affiliations":1505,"properties":1516},"f58c440a-6dbd-4dd0-b5cc-0eb9582aa2e8",[],[1506],{"id":1507,"sortIndex":25,"affiliation":1508,"properties":24},"0703d182-fa6d-4105-bce1-b8103c3d6985",{"id":1509,"createTime":1510,"updateTime":1510,"relativeEntities":1511,"slug":1512,"properties":1513,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"d612127c-2a98-4e4c-b4b9-a805e9404fad","2024-09-22T23:21:29.785+00:00",[],"Renal-Electrolyte-Section-Department-of-Medicine-University-of-Pennsylvania-School-of-Medicine-Philadelphia",{"title":1514},{"EN":1515},"Renal-Electrolyte Section, Department of Medicine, University of Pennsylvania School of Medicine , Philadelphia",{"openalex":1517,"title":1519},{"VOID":1518},"A5001055477",{"EN":1520},"Carl Goldstein",{"id":1522,"sortIndex":353,"researcher":24,"roles":1523,"affiliations":1524,"properties":1535},"c0be595d-121d-4567-a16e-631a617b38ad",[],[1525],{"id":1526,"sortIndex":25,"affiliation":1527,"properties":24},"2a290557-fa5b-4f2f-8387-51458ba03f70",{"id":1528,"createTime":1529,"updateTime":1529,"relativeEntities":1530,"slug":1531,"properties":1532,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"ad8d4da6-429c-43e3-a8cf-e6409a389d1c","2024-09-22T23:21:29.801+00:00",[],"Division-of-Neonatology-University-of-Pennsylvania-School-of-Medicine-Philadelphia",{"title":1533},{"EN":1534},"Division of Neonatology, University of Pennsylvania School of Medicine , Philadelphia",{"openalex":1536,"title":1538},{"VOID":1537},"A5058403558",{"EN":1539},"Jeffrey S. Gerdes",{"id":1541,"sortIndex":191,"researcher":24,"roles":1542,"affiliations":1543,"properties":1550},"54b97711-2ca7-4696-b8c5-457de5e1297a",[],[1544],{"id":1545,"sortIndex":25,"affiliation":1546,"properties":24},"493341bc-e784-4fbd-9cd4-dfaddfc2ca43",{"id":1509,"createTime":1510,"updateTime":1510,"relativeEntities":1547,"slug":1512,"properties":1548,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1549},{"EN":1515},{"openalex":1551,"title":1553},{"VOID":1552},"A5057835610",{"EN":1554},"R. Garrick",{"id":1556,"sortIndex":354,"researcher":24,"roles":1557,"affiliations":1558,"properties":1565},"00a2beac-3652-4e34-a9e7-3b904f59cf76",[],[1559],{"id":1560,"sortIndex":25,"affiliation":1561,"properties":24},"fec11f4f-945c-4054-a7d0-18d1aec92f84",{"id":1509,"createTime":1510,"updateTime":1510,"relativeEntities":1562,"slug":1512,"properties":1563,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1564},{"EN":1515},{"openalex":1566,"title":1568},{"VOID":1567},"A5009767474",{"EN":1569},"Eric G. Neilson",{"id":1571,"sortIndex":62,"researcher":24,"roles":1572,"affiliations":1573,"properties":1584},"b658937a-7ae2-49c8-850a-29a3c3829027",[],[1574],{"id":1575,"sortIndex":25,"affiliation":1576,"properties":24},"b7b49ecb-d953-45dd-a0d3-87b867b8aa34",{"id":1577,"createTime":1578,"updateTime":1578,"relativeEntities":1579,"slug":1580,"properties":1581,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"9d85a307-fba5-402c-8b98-338bf5f21b76","2024-09-22T23:21:29.818+00:00",[],"Division-of-Allergy-Immunology-Pulmonology-and-Bone-Marrow-Transplantation-Department-of-Pediatrics-University-of-Pennsylvania-School-of-Medicine-Philadelphia",{"title":1582},{"EN":1583},"Division of Allergy-Immunology-Pulmonology and Bone Marrow Transplantation, Department of Pediatrics, University of Pennsylvania School of Medicine , Philadelphia",{"openalex":1585,"title":1587},{"VOID":1586},"A5035953197",{"EN":1588},"Gerald B. Kolski",{"id":1590,"sortIndex":153,"researcher":24,"roles":1591,"affiliations":1592,"properties":1599},"ef42f9f2-3a8a-4ddd-bd5d-60a8a691f739",[],[1593],{"id":1594,"sortIndex":25,"affiliation":1595,"properties":24},"55f8f68d-7936-43b1-9966-eda91c3b7876",{"id":1528,"createTime":1529,"updateTime":1529,"relativeEntities":1596,"slug":1531,"properties":1597,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1598},{"EN":1534},{"openalex":1600,"orcid":1602,"title":1604},{"VOID":1601},"A5088251860",{"VOID":1603},"https:\u002F\u002Forcid.org\u002F0000-0003-2846-2023",{"EN":1605},"Richard A. Polin",{"id":1607,"sortIndex":355,"researcher":24,"roles":1608,"affiliations":1609,"properties":1616},"387bc5f0-c1da-4ed8-a78e-0b692db186b3",[],[1610],{"id":1611,"sortIndex":25,"affiliation":1612,"properties":24},"6d12e7a8-5ebb-40b6-a42a-85b894c22e0b",{"id":1577,"createTime":1578,"updateTime":1578,"relativeEntities":1613,"slug":1580,"properties":1614,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1615},{"EN":1583},{"openalex":1617,"orcid":1619,"title":1621},{"VOID":1618},"A5037161551",{"VOID":1620},"https:\u002F\u002Forcid.org\u002F0000-0002-3748-3603",{"EN":1622},"Steven D. 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In general, the macrophages showed two different PA patterns in vivo: exudate and negative macrophages. However, two of 24 CAPD patients showed resident macrophages, the first described in vivo in man. Since, in general, the examined human peritoneal macrophages are exudate and PA-negative, this suggests, in accordance with the animal model system, that a chronic sterile inflammation exists in the peritoneal cavity of CAPD patients and healthy women undergoing laparoscopy. After 2 hr culture, blood monocytes and peritoneal macrophages transformed into cells with the characteristics of exudate-resident and resident macrophages, so isolation procedures that Include short periods of culture can change the developmental stage of human monocytes and macrophages.\u003C\u002Fjats:p>",{"EN":1674},"Distinct Subpopulations of Elicited Human Macrophages in Peritoneal Dialysis Patients and Women Undergoing Laparoscopy: A Study on Peroxidatic Activity",{"VOID":1676},"3422087",{"VOID":1678},"10.1002\u002Fjlb.43.2.172",[148],"https:\u002F\u002Facademic.oup.com\u002Fjleukbio\u002Farticle\u002F43\u002F2\u002F172\u002F6978463",[1682,1711,1731,1746,1765,1784],{"id":1683,"sortIndex":153,"researcher":24,"roles":1684,"affiliations":1685,"properties":1706},"82e6994f-c684-40e3-a821-68564eb38d09",[],[1686,1696],{"id":1687,"sortIndex":25,"affiliation":1688,"properties":24},"00a08d3f-db94-4186-9def-efa364602719",{"id":1689,"createTime":1690,"updateTime":1690,"relativeEntities":1691,"slug":1692,"properties":1693,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"1d4979b8-18ad-4c52-abe8-ce992379e8fb","2024-09-22T23:21:26.454+00:00",[],"Departments-of-Gynaecology-Medical-Faculty-Free-University-Amsterdam-The-Netherlands",{"title":1694},{"EN":1695},"Departments of Gynaecology, Medical Faculty, Free University , Amsterdam , The Netherlands",{"id":1697,"sortIndex":191,"affiliation":1698,"properties":24},"13c91646-9fb9-4bed-92a7-06cd3e2e56fc",{"id":1699,"createTime":1700,"updateTime":1700,"relativeEntities":1701,"slug":1702,"properties":1703,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"4a17a7d9-8ddb-4693-859e-2245a397d08e","2024-09-22T23:21:26.458+00:00",[],"Departments-of-Obstetrics-Medical-Faculty-Free-University-Amsterdam-The-Netherlands",{"title":1704},{"EN":1705},"Departments of Obstetrics, Medical Faculty, Free University , Amsterdam , The Netherlands",{"openalex":1707,"title":1709},{"VOID":1708},"A5050650010",{"EN":1710},"T J Helmerhorst",{"id":1712,"sortIndex":25,"researcher":24,"roles":1713,"affiliations":1714,"properties":1726},"2f76dcea-2518-4d21-a9c6-f9e9462ef5d3",[],[1715],{"id":1716,"sortIndex":25,"affiliation":1717,"properties":24},"eafd3883-0d1b-4c1c-ac77-90f371b87d58",{"id":1718,"createTime":1719,"updateTime":1720,"relativeEntities":1721,"slug":1722,"properties":1723,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"6b7c69e6-12a2-40a0-ab54-1aed38d26eed","2024-02-11T17:39:55.140+00:00","2024-09-22T23:21:26.433+00:00",[],"Departments-of-Cell-Biology-Medical-Faculty-Free-University-Amsterdam-The-Netherlands",{"title":1724},{"VI":1725},"Departments of Cell Biology, Medical Faculty, Free University, Amsterdam, The Netherlands",{"openalex":1727,"title":1729},{"VOID":1728},"A5079263918",{"EN":1730},"H J Bos",{"id":1732,"sortIndex":62,"researcher":24,"roles":1733,"affiliations":1734,"properties":1741},"a63bf478-5d0c-44b6-8de3-085a1bde490b",[],[1735],{"id":1736,"sortIndex":25,"affiliation":1737,"properties":24},"735b4cf0-f581-4e96-9d6f-4d68f57f3bb8",{"id":1718,"createTime":1719,"updateTime":1720,"relativeEntities":1738,"slug":1722,"properties":1739,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1740},{"VI":1725},{"openalex":1742,"title":1744},{"VOID":1743},"A5019073771",{"EN":1745},"E.C.M. 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Beelen",{"id":1766,"sortIndex":353,"researcher":24,"roles":1767,"affiliations":1768,"properties":1779},"219538af-769f-4f14-9ce7-8ee11121e8ad",[],[1769],{"id":1770,"sortIndex":25,"affiliation":1771,"properties":24},"b32f7d17-cc94-475e-bda3-59b10eb21ddc",{"id":1772,"createTime":1773,"updateTime":1773,"relativeEntities":1774,"slug":1775,"properties":1776,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"7fd2f0a9-d70b-4b4c-a1a9-4d3c3e613401","2024-09-22T23:21:26.443+00:00",[],"Departments-of-Nephrology-Medical-Faculty-Free-University-Amsterdam-The-Netherlands",{"title":1777},{"EN":1778},"Departments of Nephrology, Medical Faculty, Free University , Amsterdam , The Netherlands",{"openalex":1780,"title":1782},{"VOID":1781},"A5056252468",{"EN":1783},"P. L. Oe",{"id":1785,"sortIndex":191,"researcher":24,"roles":1786,"affiliations":1787,"properties":1794},"90d0c308-e2d9-4ece-9d2e-27168dc9e6d4",[],[1788],{"id":1789,"sortIndex":25,"affiliation":1790,"properties":24},"4b3cbfd1-cd20-41eb-92fb-f0142f3dbd02",{"id":1772,"createTime":1773,"updateTime":1773,"relativeEntities":1791,"slug":1775,"properties":1792,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1793},{"EN":1778},{"openalex":1795,"title":1797},{"VOID":1796},"A5028646728",{"EN":1798},"H van Bronswijk",{"url":24,"publisher":1800,"properties":1825},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1801,"slug":10,"properties":1802,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1808,"manageAffiliations":1809,"indexDatabases":1810,"url":118,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1803,"issn":1804,"introduce":1805,"eissn":1806,"title":1807},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1811,1818],{"id":77,"indexDatabase":1812,"url":92,"indexYears":24,"academicFieldIds":1817,"indexDatabaseRanking":24},{"id":79,"createTime":80,"updateTime":81,"relativeEntities":1813,"label":1814,"description":1815,"key":88,"publicationTags":1816,"standard":24},[],{"EN":84,"VI":84},{"VI":86,"EN":87},[90,91],[94,95,96],{"id":98,"indexDatabase":1819,"url":111,"indexYears":112,"academicFieldIds":1824,"indexDatabaseRanking":117},{"id":100,"createTime":101,"updateTime":102,"relativeEntities":1820,"label":1821,"description":1822,"key":108,"publicationTags":1823,"standard":24},[],{"EN":105,"VI":105},{"EN":105,"VI":107},[110],[114,115,116],{"volume":1826,"pages":1828,"issue":1830},{"VOID":1827},"43",{"VOID":1829},"172-178",{"VOID":578},47,{"total":1831,"publishYear":24,"statisticByYear":1833},{"2014":191,"2018":191},"1988-02-01",1988,[],{"id":1838,"createTime":1839,"updateTime":1839,"relativeEntities":1840,"slug":1841,"properties":1842,"entityType":143,"verifyStatus":144,"verifyTime":1856,"verifyNote":146,"syncStatus":23,"languages":1857,"translateLanguages":24,"viewCount":25,"primaryUrl":1858,"fullTextUrl":24,"authors":1859,"publicationType":207,"publisherRelationship":1946,"citationCount":1978,"citationInfo":1979,"publishDate":1981,"publishYear":1982,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1983,"isForceReanalyzing":258},"452c8fbd-57fd-464c-b04a-51e4ac60c68e","2025-01-02T23:10:38.039+00:00",[],"Adiponectin-is-produced-by-lymphocytes-and-is-a-negative-regulator-of-granulopoiesis",{"mag":1843,"keywords":1845,"openalex":1846,"abstract":1848,"title":1850,"pm":1852,"doi":1854},{"VOID":1844},"2128300227",{},{"VOID":1847},"W2128300227",{"EN":1849},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:p>Transcription, translation, and secretion of adiponectin by lymphocytes is shown with receptors for adiponectin expressed on bone marrow mononuclear cells.\u003C\u002Fjats:p>\n               \u003Cjats:p>Lymphocytes have long been established to play an important role in the regulation of hematopoiesis and produce many cytokines that act on hematopoietic progenitor cells. Previous studies by our group have shown that normal, unstimulated lymphocytes produce a protein that inhibits normal bone marrow GM colony formation. Adiponectin is an adipokine that has been demonstrated to act as a negative regulator of hematopoiesis and immune function. This study aimed to determine if the inhibitory molecule that we described previously was adiponectin. Here, we show transcription, translation, and secretion of adiponectin from lymphocytes and demonstrate that its receptors, AdipoR1 and AdipoR2, are expressed by bone marrow MNCs. We show that although the adiponectin expression is low in lymphocytes, it is sufficient to induce a significant inhibitory effect on GM precursors (CFU-GM) and activate the AMPK pathway in these cells. The regulation of adiponectin production by lymphocytes and its detailed function in suppressing GM colony formation need to be elucidated now. Our findings suggest a functional role for adiponectin as a negative regulator of granulopoiesis.\u003C\u002Fjats:p>",{"EN":1851},"Adiponectin is produced by lymphocytes and is a negative regulator of granulopoiesis",{"VOID":1853},"20643815",{"VOID":1855},"10.1189\u002Fjlb.1109723","2025-01-02T23:10:38.038+00:00",[148],"https:\u002F\u002Facademic.oup.com\u002Fjleukbio\u002Farticle\u002F88\u002F4\u002F807\u002F6959680",[1860,1879,1894,1914,1931],{"id":1861,"sortIndex":153,"researcher":24,"roles":1862,"affiliations":1863,"properties":1874},"31a61933-6e5f-4c1b-9f54-d06f91004fae",[],[1864],{"id":1865,"sortIndex":25,"affiliation":1866,"properties":24},"55b3b257-a34b-463e-9dff-d98748014d33",{"id":1867,"createTime":1868,"updateTime":1868,"relativeEntities":1869,"slug":1870,"properties":1871,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"e0a1e642-c11f-46ee-9a96-42e2a298da17","2025-01-02T23:10:38.108+00:00",[],"Centre-for-Cancer-Research-and-Cell-Biology-Queen%CB%88s-University-Belfast-Belfast-Northern-Ireland",{"title":1872},{"EN":1873},"Centre for Cancer Research and Cell Biology, Queenˈs University Belfast , Belfast, Northern Ireland",{"openalex":1875,"title":1877},{"VOID":1876},"A5090277919",{"EN":1878},"Susan Price",{"id":1880,"sortIndex":191,"researcher":24,"roles":1881,"affiliations":1882,"properties":1889},"2091887b-51f6-439f-8019-e3194a9bca49",[],[1883],{"id":1884,"sortIndex":25,"affiliation":1885,"properties":24},"3597b0a2-dbc5-4c14-908a-b42a726e53ae",{"id":1867,"createTime":1868,"updateTime":1868,"relativeEntities":1886,"slug":1870,"properties":1887,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1888},{"EN":1873},{"openalex":1890,"title":1892},{"VOID":1891},"A5113858137",{"EN":1893},"Roy W A Peake",{"id":1895,"sortIndex":353,"researcher":24,"roles":1896,"affiliations":1897,"properties":1909},"551b2a56-866c-415d-8cc5-2e0aa2725ca3",[],[1898],{"id":1899,"sortIndex":25,"affiliation":1900,"properties":24},"29faee96-626d-44fd-80e0-f75f79784678",{"id":1901,"createTime":1902,"updateTime":1903,"relativeEntities":1904,"slug":1905,"properties":1906,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"2bf71f90-37e1-46f0-a45d-9b9ed0bcacdd","2023-12-01T01:55:23.769+00:00","2025-01-02T23:10:38.236+00:00",[],"Department-of-Haematology-Belfast-City-Hospital-Belfast-Northern-Ireland",{"title":1907},{"VI":1908},"Department of Haematology, Belfast City Hospital, Belfast, Northern Ireland",{"openalex":1910,"title":1912},{"VOID":1911},"A5112243071",{"EN":1913},"T. C. M. 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Immunol. Ther. Exp. (Warsz.), 53, 505",{},{"id":24,"text":1988,"url":24,"identifiers":1989},"Zhan, 1998, Essential roles for granulocyte-macrophage colony-stimulating factor (GM-CSF) and G-CSF in the sustained hematopoietic response of Listeria monocytogenes-infected mice, Blood, 91, 863, 10.1182\u002Fblood.V91.3.863",{"doi":1990},"10.1182\u002Fblood.V91.3.863",{"id":24,"text":1992,"url":24,"identifiers":1993},"Morris, 1980, Inhibition of normal human granulopoiesis in vitro by non-B non-T lymphocytes, Br. J. Haematol., 45, 541, 10.1111\u002Fj.1365-2141.1980.tb07176.x",{"doi":1994},"10.1111\u002Fj.1365-2141.1980.tb07176.x",{"id":24,"text":1996,"url":24,"identifiers":1997},"Irvine, 1991, Normal unstimulated lymphocytes produce granulopoietic inhibitory activity, Exp. Hematol., 19, 106",{},{"id":24,"text":1999,"url":24,"identifiers":2000},"Morris, 1984, CFU-C inhibitors in aplastic anemia, Blut, 48, 61, 10.1007\u002FBF00320032",{"doi":2001},"10.1007\u002FBF00320032",{"id":24,"text":2003,"url":24,"identifiers":2004},"Morris, 1989, CFU-GM inhibitors in neutropenia, Clin. Lab. Haematol., 11, 31, 10.1111\u002Fj.1365-2257.1989.tb00172.x",{"doi":2005},"10.1111\u002Fj.1365-2257.1989.tb00172.x",{"id":24,"text":2007,"url":24,"identifiers":2008},"Irvine, 1986, Lymphocytes from patients receiving lithium do not inhibit CFU-C growth, Br. J. Haematol., 62, 467, 10.1111\u002Fj.1365-2141.1986.tb02958.x",{"doi":2009},"10.1111\u002Fj.1365-2141.1986.tb02958.x",{"id":24,"text":2011,"url":24,"identifiers":2012},"Morris, 1987, The Inhibitors of Hematopoiesis, 69",{},{"id":24,"text":2014,"url":24,"identifiers":2015},"Stevenson, 1993, The Negative Regulation of Hematopoiesis, 229",{},{"id":24,"text":2017,"url":24,"identifiers":2018},"Yokota, 2000, Adiponectin, a new member of the soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages, Blood, 96, 1723, 10.1182\u002Fblood.V96.5.1723",{"doi":2019},"10.1182\u002Fblood.V96.5.1723",{"id":24,"text":2021,"url":24,"identifiers":2022},"Yamauchi, 2003, Cloning of adiponectin receptors that mediate antidiabetic metabolic effects, Nature, 423, 762, 10.1038\u002Fnature01705",{"doi":2023},"10.1038\u002Fnature01705",{"id":24,"text":2025,"url":24,"identifiers":2026},"Lara-Castro, 2007, Adiponectin and the metabolic syndrome: mechanisms mediating risk for metabolic and cardiovascular disease, Curr. Opin. Lipidol., 18, 263, 10.1097\u002FMOL.0b013e32814a645f",{"doi":2027},"10.1097\u002FMOL.0b013e32814a645f",{"id":24,"text":2029,"url":24,"identifiers":2030},"DiMascio, 2007, Identification of adiponectin as a novel hemopoietic stem cell growth factor, J. Immunol., 178, 3511, 10.4049\u002Fjimmunol.178.6.3511",{"doi":2031},"10.4049\u002Fjimmunol.178.6.3511",{"id":24,"text":2033,"url":24,"identifiers":2034},"Avcu, 2006, Association of plasma adiponectin concentrations with chronic lymphocytic leukemia and myeloproliferative diseases, Int. J. Hematol, 83, 254, 10.1532\u002FIJH97.NA0411",{"doi":2035},"10.1532\u002FIJH97.NA0411",{"id":24,"text":2037,"url":24,"identifiers":2038},"Molica, 2008, Prognostic relevance of serum levels and cellular expression of adiponectin in B-cell chronic lymphocytic leukemia, Int. J. Hematol., 88, 374, 10.1007\u002Fs12185-008-0165-5",{"doi":2039},"10.1007\u002Fs12185-008-0165-5",{"id":24,"text":2041,"url":24,"identifiers":2042},"Petridou, 2006, Adiponectin in relation to childhood myeloblastic leukemia, Br. J. Cancer, 94, 156, 10.1038\u002Fsj.bjc.6602896",{"doi":2043},"10.1038\u002Fsj.bjc.6602896",{"id":24,"text":2045,"url":24,"identifiers":2046},"Dalamaga, 2008, Adiponectin and resistin are associated with risk for myelodysplastic syndrome, independently from the insulin-like growth factor-1 (IGF-1) system, Eur. J. Cancer, 44, 1744, 10.1016\u002Fj.ejca.2008.04.015",{"doi":2047},"10.1016\u002Fj.ejca.2008.04.015",{"id":24,"text":2049,"url":24,"identifiers":2050},"Dalamaga, 2009, Low circulating adiponectin and resistin, but not leptin, levels are associated with multiple myeloma risk: a case-control study, Cancer Causes Control, 20, 193, 10.1007\u002Fs10552-008-9233-7",{"doi":2051},"10.1007\u002Fs10552-008-9233-7",{"id":24,"text":2053,"url":24,"identifiers":2054},"Berner, 2004, Adiponectin and its receptors are expressed in bone-forming cells, Bone, 35, 842, 10.1016\u002Fj.bone.2004.06.008",{"doi":2055},"10.1016\u002Fj.bone.2004.06.008",{"id":24,"text":2057,"url":24,"identifiers":2058},"Pineiro, 2005, Adiponectin is synthesized and secreted by human and murine cardiomyocytes, FEBS Lett., 579, 5163, 10.1016\u002Fj.febslet.2005.07.098",{"doi":2059},"10.1016\u002Fj.febslet.2005.07.098",{"id":24,"text":2061,"url":24,"identifiers":2062},"Katsiougiannis, 2006, Salivary gland epithelial cells: a new source of the immunoregulatory hormone adiponectin, Arthritis Rheum., 54, 2295, 10.1002\u002Fart.21944",{"doi":2063},"10.1002\u002Fart.21944",{"id":24,"text":2065,"url":24,"identifiers":2066},"Miller, 2009, Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease, J. Immunol., 182, 684, 10.4049\u002Fjimmunol.182.1.684",{"doi":2067},"10.4049\u002Fjimmunol.182.1.684",{"id":24,"text":2069,"url":24,"identifiers":2070},"Pike, 1970, Human bone marrow colony growth in agar-gel, J. Cell. Physiol., 76, 77, 10.1002\u002Fjcp.1040760111",{"doi":2071},"10.1002\u002Fjcp.1040760111",{"id":24,"text":2073,"url":24,"identifiers":2074},"Hada, 2007, Selective purification and characterization of adiponectin multimer species from human plasma, Biochem. Biophys. Res. Commun., 356, 487, 10.1016\u002Fj.bbrc.2007.03.004",{"doi":2075},"10.1016\u002Fj.bbrc.2007.03.004",{"id":24,"text":2077,"url":24,"identifiers":2078},"Waki, 2003, Impaired multimerization of human adiponectin mutants associated with diabetes, J. Biol. Chem., 278, 40352, 10.1074\u002Fjbc.M300365200",{"doi":2079},"10.1074\u002Fjbc.M300365200",{"id":24,"text":2081,"url":24,"identifiers":2082},"Ujiie, 2006, Idenification of amino-terminal region of adiponectin as a physiologically functional domain, J. Cell. Biochem., 98, 194, 10.1002\u002Fjcb.20779",{"doi":2083},"10.1002\u002Fjcb.20779",{"id":24,"text":2085,"url":24,"identifiers":2086},"Skokowa, 2009, NAMPT is essential for the GCSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway, Nat. Med., 15, 151, 10.1038\u002Fnm.1913",{"doi":2087},"10.1038\u002Fnm.1913",{"id":24,"text":2089,"url":24,"identifiers":2090},"Claycombe, 2008, A role for leptin in sustaining lymphopoiesis and myelopoiesis, Proc. Natl. Acad. Sci. USA, 105, 2017, 10.1073\u002Fpnas.0712053105",{"doi":2091},"10.1073\u002Fpnas.0712053105",{"id":24,"text":2093,"url":24,"identifiers":2094},"Kim, 2010, Molecular mechanisms of cellular proliferation in acute myelogenous leukemia by leptin, Oncol. Rep., 23, 1369",{},{"id":24,"text":2096,"url":24,"identifiers":2097},"Zhang, 1995, Tumor necrosis factor is a physiological regulator of hematopoietic progenitor cells: increase of early hematopoietic progenitor cells in TNF receptor p55-deficient mice in vivo and potent inhibition of progenitor cell proliferation of TNF α in vitro, Blood, 86, 2930, 10.1182\u002Fblood.V86.8.2930.2930",{"doi":2098},"10.1182\u002Fblood.V86.8.2930.2930",{"id":24,"text":2100,"url":24,"identifiers":2101},"Iversen, 2005, Tumor necrosis factor α and adiponectin in bone marrow interstitial fluid from patients with acute myeloid leukemia inhibit normal hematopoiesis, Clin. Cancer Res., 11, 6793, 10.1158\u002F1078-0432.CCR-05-1033",{"doi":2102},"10.1158\u002F1078-0432.CCR-05-1033",{"id":2104,"createTime":2105,"updateTime":2105,"relativeEntities":2106,"slug":2107,"properties":2108,"entityType":143,"verifyStatus":144,"verifyTime":2122,"verifyNote":146,"syncStatus":23,"languages":2123,"translateLanguages":24,"viewCount":25,"primaryUrl":2124,"fullTextUrl":24,"authors":2125,"publicationType":207,"publisherRelationship":2195,"citationCount":2227,"citationInfo":2228,"publishDate":2237,"publishYear":2238,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":2239,"isForceReanalyzing":258},"10110359-39d9-4618-88e7-81c1272afe9b","2024-10-10T23:04:51.928+00:00",[],"Accelerated-wound-closure-in-neutrophil-depleted-mice",{"mag":2109,"keywords":2111,"openalex":2112,"abstract":2114,"title":2116,"pm":2118,"doi":2120},{"VOID":2110},"2163105501",{},{"VOID":2113},"W2163105501",{"EN":2115},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:p>The infiltration of neutrophils into injured tissue is known to protect wounds from invading pathogens. However, more recent studies suggest that neutrophils might inhibit the wound repair process. To investigate the role of neutrophils in wounds, mice were neutrophil-depleted by injection with rabbit anti-mouse neutrophil serum. Remarkably, epidermal healing, measured by wound closure, proceeded significantly faster in neutropenic than control mice (77.7+14.2% vs. 41.2+0.9%, P<0.02 at day 2). Dermal healing was not affected by neutrophil depletion, as neither collagen deposition nor wound-breaking strength was significantly different between neutropenic and control mice. As the delayed repair of diabetic individuals exhibits robust inflammation, the effect of neutrophil depletion on diabetic wound healing was investigated. Similar to the observations in wild-type mice, wound closure was accelerated by nearly 50% in neutropenic, diabetic mice. The results suggest that although neutrophils may provide protection against infection, they may retard wound closure.\u003C\u002Fjats:p>",{"EN":2117},"Accelerated wound closure in neutrophil-depleted mice",{"VOID":2119},"12660219",{"VOID":2121},"10.1189\u002Fjlb.0802406","2024-10-10T23:04:51.927+00:00",[148],"https:\u002F\u002Facademic.oup.com\u002Fjleukbio\u002Farticle\u002F73\u002F4\u002F448\u002F6979412",[2126,2155,2172],{"id":2127,"sortIndex":25,"researcher":24,"roles":2128,"affiliations":2129,"properties":2150},"11aa146b-3168-4504-80de-9fcf02228f3f",[],[2130,2140],{"id":2131,"sortIndex":25,"affiliation":2132,"properties":24},"afa14151-d6b5-4139-80e2-b402e3729cdf",{"id":2133,"createTime":2134,"updateTime":2134,"relativeEntities":2135,"slug":2136,"properties":2137,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"8a8dfd9d-7151-49ab-827e-b49b315cb098","2024-10-10T23:04:51.946+00:00",[],"Department-of-Microbiology-and-Immunology-Burn-and-Shock-Trauma-Institute-Loyola-University-Medical-Center-Maywood-Illinois",{"title":2138},{"EN":2139},"Department of Microbiology and Immunology, Burn and Shock Trauma Institute, Loyola University Medical Center , Maywood, Illinois",{"id":2141,"sortIndex":191,"affiliation":2142,"properties":24},"6c061f54-2d95-4edd-86f7-cbe76c0deb92",{"id":2143,"createTime":2144,"updateTime":2144,"relativeEntities":2145,"slug":2146,"properties":2147,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"71922769-3c0c-4d73-a005-d7547c869a38","2024-10-10T23:04:51.951+00:00",[],"Department-of-Surgery-Burn-and-Shock-Trauma-Institute-Loyola-University-Medical-Center-Maywood-Illinois",{"title":2148},{"EN":2149},"Department of Surgery, Burn and Shock Trauma Institute, Loyola University Medical Center , Maywood, Illinois",{"openalex":2151,"title":2153},{"VOID":2152},"A5084430668",{"EN":2154},"Julia V. Dovi",{"id":2156,"sortIndex":191,"researcher":24,"roles":2157,"affiliations":2158,"properties":2165},"3459b1d2-3573-4662-9ccf-996cd74185aa",[],[2159],{"id":2160,"sortIndex":25,"affiliation":2161,"properties":24},"71753afd-1ab6-4fc4-ae48-260754defb0d",{"id":2143,"createTime":2144,"updateTime":2144,"relativeEntities":2162,"slug":2146,"properties":2163,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2164},{"EN":2149},{"openalex":2166,"orcid":2168,"title":2170},{"VOID":2167},"A5017370608",{"VOID":2169},"https:\u002F\u002Forcid.org\u002F0009-0002-2081-2391",{"EN":2171},"Li‐Ke He",{"id":2173,"sortIndex":153,"researcher":24,"roles":2174,"affiliations":2175,"properties":2188},"f97009c8-9e8c-414f-ba61-acae1312dc68",[],[2176,2182],{"id":2177,"sortIndex":191,"affiliation":2178,"properties":24},"a02214e4-04ca-49b9-a6d0-a232896f5560",{"id":2143,"createTime":2144,"updateTime":2144,"relativeEntities":2179,"slug":2146,"properties":2180,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2181},{"EN":2149},{"id":2183,"sortIndex":25,"affiliation":2184,"properties":24},"a49af9fe-c566-4944-a351-b08bc266eb66",{"id":2133,"createTime":2134,"updateTime":2134,"relativeEntities":2185,"slug":2136,"properties":2186,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2187},{"EN":2139},{"openalex":2189,"orcid":2191,"title":2193},{"VOID":2190},"A5001159362",{"VOID":2192},"https:\u002F\u002Forcid.org\u002F0000-0002-4842-1547",{"EN":2194},"Luisa A. DiPietro",{"url":24,"publisher":2196,"properties":2221},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2197,"slug":10,"properties":2198,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":2204,"manageAffiliations":2205,"indexDatabases":2206,"url":118,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":2199,"issn":2200,"introduce":2201,"eissn":2202,"title":2203},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[2207,2214],{"id":77,"indexDatabase":2208,"url":92,"indexYears":24,"academicFieldIds":2213,"indexDatabaseRanking":24},{"id":79,"createTime":80,"updateTime":81,"relativeEntities":2209,"label":2210,"description":2211,"key":88,"publicationTags":2212,"standard":24},[],{"EN":84,"VI":84},{"VI":86,"EN":87},[90,91],[94,95,96],{"id":98,"indexDatabase":2215,"url":111,"indexYears":112,"academicFieldIds":2220,"indexDatabaseRanking":117},{"id":100,"createTime":101,"updateTime":102,"relativeEntities":2216,"label":2217,"description":2218,"key":108,"publicationTags":2219,"standard":24},[],{"EN":105,"VI":105},{"EN":105,"VI":107},[110],[114,115,116],{"volume":2222,"pages":2224,"issue":2226},{"VOID":2223},"73",{"VOID":2225},"448-455",{"VOID":349},500,{"total":2227,"publishYear":24,"statisticByYear":2229},{"2012":2230,"2013":2231,"2014":2232,"2015":583,"2016":583,"2017":2233,"2018":583,"2019":2234,"2020":245,"2021":251,"2022":2235,"2023":2236,"2024":1270},24,27,33,39,31,25,28,"2003-04-01",2003,[2240,2243,2246,2250,2254,2258,2261,2265,2269,2273,2277,2281,2284,2287,2291,2295,2299,2303,2307,2311,2315,2319,2323,2327,2331,2335],{"id":24,"text":2241,"url":24,"identifiers":2242},"Clark, 1996, Wound repair: overview and general considerations, 3",{},{"id":24,"text":2244,"url":24,"identifiers":2245},"Moore, 1999, Cell biology of chronic wounds: the role of inflammation, J. Wound Care, 8, 345",{},{"id":24,"text":2247,"url":24,"identifiers":2248},"Pierce, 2001, Inflammation in nonhealing diabetic wounds. The space-time continuum does matter, Am. J. Pathol., 159, 399, 10.1016\u002FS0002-9440(10)61709-9",{"doi":2249},"10.1016\u002FS0002-9440(10)61709-9",{"id":24,"text":2251,"url":24,"identifiers":2252},"Jutila, 1988, Ly-6C is a monocyte\u002Fmacrophage and endothelial cell differentiation antigen regulated by interferon-gamma, Eur. J. Immunol., 18, 1819, 10.1002\u002Feji.1830181125",{"doi":2253},"10.1002\u002Feji.1830181125",{"id":24,"text":2255,"url":24,"identifiers":2256},"Lewinsohn, 1987, Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophil, lymphocytes, and other leukocytes, J. Immunol., 138, 4313, 10.4049\u002Fjimmunol.138.12.4313",{"doi":2257},"10.4049\u002Fjimmunol.138.12.4313",{"id":24,"text":2259,"url":24,"identifiers":2260},"Margulies, 1991, Current Protocols in Immunology",{},{"id":24,"text":2262,"url":24,"identifiers":2263},"Suzuki, 1983, Assay method for myeloperoxidase in human polymorphonuclear leukocytes, Anal. Biochem., 132, 345, 10.1016\u002F0003-2697(83)90019-2",{"doi":2264},"10.1016\u002F0003-2697(83)90019-2",{"id":24,"text":2266,"url":24,"identifiers":2267},"Schierwagen, 1990, Improved method for quantification of tissue PMN accumulation measured by myeloperoxidase activity, J. Pharmacol. Methods, 23, 179, 10.1016\u002F0160-5402(90)90061-O",{"doi":2268},"10.1016\u002F0160-5402(90)90061-O",{"id":24,"text":2270,"url":24,"identifiers":2271},"Woessner, 1961, The determination of hydroxyproline in tissue and protein samples containing small proportions of the imino acid, Arch. Biochem. Biophys., 93, 440, 10.1016\u002F0003-9861(61)90291-0",{"doi":2272},"10.1016\u002F0003-9861(61)90291-0",{"id":24,"text":2274,"url":24,"identifiers":2275},"Hestdal, 1991, Characterization and regulation of RB6–8C5 antigen expression on murine bone marrow cells, J. Immunol., 147, 22, 10.4049\u002Fjimmunol.147.1.22",{"doi":2276},"10.4049\u002Fjimmunol.147.1.22",{"id":24,"text":2278,"url":24,"identifiers":2279},"Danon, 1989, Promotion of wound repair in old mice by local injection of macrophages, Proc. Natl. Acad. Sci. USA, 86, 2018, 10.1073\u002Fpnas.86.6.2018",{"doi":2280},"10.1073\u002Fpnas.86.6.2018",{"id":24,"text":2282,"url":24,"identifiers":2283},"Leibovich, 1975, The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum, Am. J. Pathol., 78, 71",{},{"id":24,"text":2285,"url":24,"identifiers":2286},"DiPietro, 1993, Role of the macrophage in the positive and negative regulation of wound neovascularization, Am. J. Pathol., 143, 678",{},{"id":24,"text":2288,"url":24,"identifiers":2289},"DiPietro, 1995, Wound healing: the role of the macrophage and other immune cells, Shock, 4, 233, 10.1097\u002F00024382-199510000-00001",{"doi":2290},"10.1097\u002F00024382-199510000-00001",{"id":24,"text":2292,"url":24,"identifiers":2293},"DiPietro, 1998, MIP-1alpha as a critical macrophage chemoattractant in murine wound repair, J. Clin. Invest., 101, 1693, 10.1172\u002FJCI1020",{"doi":2294},"10.1172\u002FJCI1020",{"id":24,"text":2296,"url":24,"identifiers":2297},"Wetzler, 2000, Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair, J. Invest. Dermatol., 115, 245, 10.1046\u002Fj.1523-1747.2000.00029.x",{"doi":2298},"10.1046\u002Fj.1523-1747.2000.00029.x",{"id":24,"text":2300,"url":24,"identifiers":2301},"Moore, 1997, T lymphocytes and the lack of activated macrophages in wound margin biopsies from chronic leg ulcers, Br. J. Dermatol., 137, 188, 10.1046\u002Fj.1365-2133.1997.18041895.x",{"doi":2302},"10.1046\u002Fj.1365-2133.1997.18041895.x",{"id":24,"text":2304,"url":24,"identifiers":2305},"Simpson, 1972, The neutrophilic leukocyte in wound repair. A study with antineutrophil serum, J. Clin. Invest., 51, 2009, 10.1172\u002FJCI107007",{"doi":2306},"10.1172\u002FJCI107007",{"id":24,"text":2308,"url":24,"identifiers":2309},"Devalaraja, 2000, Delayed wound healing in CXCR2 knock out mice, J. Invest. Dermatol., 115, 234, 10.1046\u002Fj.1523-1747.2000.00034.x",{"doi":2310},"10.1046\u002Fj.1523-1747.2000.00034.x",{"id":24,"text":2312,"url":24,"identifiers":2313},"Ashcroft, 2000, Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing, Nat. Med., 6, 1147, 10.1038\u002F80489",{"doi":2314},"10.1038\u002F80489",{"id":24,"text":2316,"url":24,"identifiers":2317},"Rennekampff, 2000, Bioactive interleukin-8 is expressed in wounds and enhances wound healing, J. Surg. Res., 93, 41, 10.1006\u002Fjsre.2000.5892",{"doi":2318},"10.1006\u002Fjsre.2000.5892",{"id":24,"text":2320,"url":24,"identifiers":2321},"McCourt, 1999, Proinflammatory mediators stimulate neutrophil-directed angiogenesis, Arch. Surg., 134, 1325, 10.1001\u002Farchsurg.134.12.1325",{"doi":2322},"10.1001\u002Farchsurg.134.12.1325",{"id":24,"text":2324,"url":24,"identifiers":2325},"Briggaman, 1984, Degradation of the epidermal-dermal junction by proteolytic enzymes from human skin and human polymorphonuclear leukocytes, J. Exp. Med., 160, 1027, 10.1084\u002Fjem.160.4.1027",{"doi":2326},"10.1084\u002Fjem.160.4.1027",{"id":24,"text":2328,"url":24,"identifiers":2329},"Katayama, 1994, Detachment of cultured normal human keratinocytes by contact with TNF alpha-stimulated neutrophils in the presence of platelet-activating factor, J. Invest. Dermatol., 103, 187, 10.1111\u002F1523-1747.ep12392711",{"doi":2330},"10.1111\u002F1523-1747.ep12392711",{"id":24,"text":2332,"url":24,"identifiers":2333},"Makela, 1999, Matrix metalloproteinase 2 (gelatinase A) is related to migration of keratinocytes, Exp. Cell Res., 251, 67, 10.1006\u002Fexcr.1999.4564",{"doi":2334},"10.1006\u002Fexcr.1999.4564",{"id":24,"text":2336,"url":24,"identifiers":2337},"Pilcher, 1997, The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix, J. Cell Biol., 137, 1445, 10.1083\u002Fjcb.137.6.1445",{"doi":2338},"10.1083\u002Fjcb.137.6.1445",{"id":2340,"createTime":2341,"updateTime":2341,"relativeEntities":2342,"slug":2343,"properties":2344,"entityType":143,"verifyStatus":144,"verifyTime":2360,"verifyNote":146,"syncStatus":23,"languages":2361,"translateLanguages":24,"viewCount":25,"primaryUrl":2362,"fullTextUrl":24,"authors":2363,"publicationType":207,"publisherRelationship":2420,"citationCount":2452,"citationInfo":2453,"publishDate":2459,"publishYear":2460,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":2461,"isForceReanalyzing":258},"5b7f84da-cceb-493a-8ab8-0bd29134444e","2024-09-22T23:00:32.392+00:00",[],"Monocyte-heterogeneity-and-functions-in-cancer",{"mag":2345,"keywords":2347,"pmc":2348,"openalex":2350,"abstract":2352,"title":2354,"pm":2356,"doi":2358},{"VOID":2346},"2916964158",{},{"VOID":2349},"6658332",{"VOID":2351},"W2916964158",{"EN":2353},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:p>Monocytes are innate immune cells of the mononuclear phagocyte system that have emerged as important regulators of cancer development and progression. Our understanding of monocytes has advanced from viewing these cells as a homogenous population to a heterogeneous system of cells that display diverse responses to different stimuli. During cancer, different monocyte subsets perform functions that contribute to both pro- and antitumoral immunity, including phagocytosis, secretion of tumoricidal mediators, promotion of angiogenesis, remodeling of the extracellular matrix, recruitment of lymphocytes, and differentiation into tumor-associated macrophages and dendritic cells. The ability of cancer to evade immune recognition and clearance requires protumoral signals to outweigh ongoing attempts by the host immune system to prevent tumor growth. This review discusses current understanding of monocyte heterogeneity during homeostasis, highlights monocyte functions in cancer progression, and describes monocyte-targeted therapeutic strategies for cancer treatment.\u003C\u002Fjats:p>",{"EN":2355},"Monocyte heterogeneity and functions in cancer",{"VOID":2357},"30776148",{"VOID":2359},"10.1002\u002Fjlb.4ri0818-311r","2024-09-22T23:00:32.391+00:00",[148],"https:\u002F\u002Facademic.oup.com\u002Fjleukbio\u002Farticle\u002F106\u002F2\u002F309\u002F6935815",[2364,2386,2403],{"id":2365,"sortIndex":25,"researcher":24,"roles":2366,"affiliations":2367,"properties":2379},"7a98a168-6a65-4e4a-8a70-3131e79dd327",[],[2368],{"id":2369,"sortIndex":25,"affiliation":2370,"properties":24},"e60dc2d9-edd3-4a20-b2d5-203e8d1006fc",{"id":2371,"createTime":2372,"updateTime":2373,"relativeEntities":2374,"slug":2375,"properties":2376,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"3922e717-6cb5-4b53-b2e9-431600211284","2023-12-07T01:47:26.418+00:00","2024-09-22T23:00:32.446+00:00",[],"La-Jolla-Institute-for-Allergy-and-Immunology-La-Jolla-California-USA",{"title":2377},{"VI":2378},"La Jolla Institute for Allergy and Immunology, La Jolla, California, USA",{"openalex":2380,"orcid":2382,"title":2384},{"VOID":2381},"A5023890115",{"VOID":2383},"https:\u002F\u002Forcid.org\u002F0000-0002-4449-4319",{"EN":2385},"Claire Olingy",{"id":2387,"sortIndex":191,"researcher":24,"roles":2388,"affiliations":2389,"properties":2396},"995a526b-511b-4321-8beb-4ed94d09ac14",[],[2390],{"id":2391,"sortIndex":25,"affiliation":2392,"properties":24},"21c785ad-a070-4436-b61c-c3bec95eb51f",{"id":2371,"createTime":2372,"updateTime":2373,"relativeEntities":2393,"slug":2375,"properties":2394,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2395},{"VI":2378},{"openalex":2397,"orcid":2399,"title":2401},{"VOID":2398},"A5068034920",{"VOID":2400},"https:\u002F\u002Forcid.org\u002F0000-0002-3307-1126",{"EN":2402},"Huy Q. Dinh",{"id":2404,"sortIndex":153,"researcher":24,"roles":2405,"affiliations":2406,"properties":2413},"54a4e39e-7472-47b0-b341-f55ad39724e0",[],[2407],{"id":2408,"sortIndex":25,"affiliation":2409,"properties":24},"7466bc0e-cddb-4a98-ba68-64b353e2851a",{"id":2371,"createTime":2372,"updateTime":2373,"relativeEntities":2410,"slug":2375,"properties":2411,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2412},{"VI":2378},{"openalex":2414,"orcid":2416,"title":2418},{"VOID":2415},"A5045616017",{"VOID":2417},"https:\u002F\u002Forcid.org\u002F0000-0003-2045-4117",{"EN":2419},"Catherine C. Hedrick",{"url":24,"publisher":2421,"properties":2446},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2422,"slug":10,"properties":2423,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":2429,"manageAffiliations":2430,"indexDatabases":2431,"url":118,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":2424,"issn":2425,"introduce":2426,"eissn":2427,"title":2428},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[2432,2439],{"id":77,"indexDatabase":2433,"url":92,"indexYears":24,"academicFieldIds":2438,"indexDatabaseRanking":24},{"id":79,"createTime":80,"updateTime":81,"relativeEntities":2434,"label":2435,"description":2436,"key":88,"publicationTags":2437,"standard":24},[],{"EN":84,"VI":84},{"VI":86,"EN":87},[90,91],[94,95,96],{"id":98,"indexDatabase":2440,"url":111,"indexYears":112,"academicFieldIds":2445,"indexDatabaseRanking":117},{"id":100,"createTime":101,"updateTime":102,"relativeEntities":2441,"label":2442,"description":2443,"key":108,"publicationTags":2444,"standard":24},[],{"EN":105,"VI":105},{"EN":105,"VI":107},[110],[114,115,116],{"volume":2447,"pages":2449,"issue":2451},{"VOID":2448},"106",{"VOID":2450},"309-322",{"VOID":578},397,{"total":2452,"publishYear":24,"statisticByYear":2454},{"2019":1275,"2020":2233,"2021":2455,"2022":2456,"2023":2457,"2024":2458},82,98,103,66,"2019-07-25",2019,[2462,2466,2470,2474,2478,2480,2484,2488,2492,2496,2500,2504,2508,2512,2516,2520,2524,2528,2532,2536,2540,2544,2548,2552,2556,2560,2564,2568,2572,2576,2580,2584,2588,2592,2596,2600,2604,2608,2612,2616,2620,2624,2628,2632,2636,2640,2644,2648,2652,2656,2660,2664,2668,2672,2676,2680,2684,2688,2692,2696,2700,2704,2708,2712,2716,2720,2724,2728,2732,2736,2740,2744,2747,2751,2755,2759,2763,2767,2771,2775,2779,2783,2787,2791,2795,2799,2803,2807,2811,2815,2819,2823,2827,2831,2835,2839,2843,2847,2851,2855,2859,2863,2867,2871,2874,2878,2882,2886,2890,2894,2898,2902,2906,2910,2914,2918,2922,2926,2930,2933,2937,2941,2945,2949,2953,2957,2961,2965,2969,2973,2977,2981,2985,2989,2993,2997,3001,3005,3009,3013,3017,3021,3025,3029,3032,3036],{"id":24,"text":2463,"url":24,"identifiers":2464},"Shi, 2011, Monocyte recruitment during infection and inflammation, Nat Rev Immunol, 11, 762, 10.1038\u002Fnri3070",{"doi":2465},"10.1038\u002Fnri3070",{"id":24,"text":2467,"url":24,"identifiers":2468},"Qian, 2011, CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis, Nature, 475, 222, 10.1038\u002Fnature10138",{"doi":2469},"10.1038\u002Fnature10138",{"id":24,"text":2471,"url":24,"identifiers":2472},"Hanna, 2015, Patrolling monocytes control tumor metastasis to the lung, Science, 350, 985, 10.1126\u002Fscience.aac9407",{"doi":2473},"10.1126\u002Fscience.aac9407",{"id":24,"text":2475,"url":24,"identifiers":2476},"Engblom, 2016, The role of myeloid cells in cancer therapies, Nat Rev Cancer, 16, 447, 10.1038\u002Fnrc.2016.54",{"doi":2477},"10.1038\u002Fnrc.2016.54",{"id":24,"text":883,"url":24,"identifiers":2479},{"doi":885},{"id":24,"text":2481,"url":24,"identifiers":2482},"Passlick, 1989, Identification and characterization of a novel monocyte subpopulation in human peripheral blood, Blood, 74, 2527, 10.1182\u002Fblood.V74.7.2527.2527",{"doi":2483},"10.1182\u002Fblood.V74.7.2527.2527",{"id":24,"text":2485,"url":24,"identifiers":2486},"Palframan, 2001, Inflammatory chemokine transport and presentation in hev: A remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues, J Exp Med, 194, 1361, 10.1084\u002Fjem.194.9.1361",{"doi":2487},"10.1084\u002Fjem.194.9.1361",{"id":24,"text":2489,"url":24,"identifiers":2490},"Geissmann, 2003, Blood monocytes consist of two principal subsets with distinct migratory properties, Immunity, 19, 71, 10.1016\u002FS1074-7613(03)00174-2",{"doi":2491},"10.1016\u002FS1074-7613(03)00174-2",{"id":24,"text":2493,"url":24,"identifiers":2494},"Sunderkötter, 2004, Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response, J Immunol, 172, 4410, 10.4049\u002Fjimmunol.172.7.4410",{"doi":2495},"10.4049\u002Fjimmunol.172.7.4410",{"id":24,"text":2497,"url":24,"identifiers":2498},"Ingersoll, 2010, Comparison of gene expression profiles between human and mouse monocyte subsets, Blood, 115, e10, 10.1182\u002Fblood-2009-07-235028",{"doi":2499},"10.1182\u002Fblood-2009-07-235028",{"id":24,"text":2501,"url":24,"identifiers":2502},"Mildner, 2017, Genomic characterization of murine monocytes reveals C\u002FEBPβ transcription factor dependence of Ly6C− cells, Immunity, 46, 849, 10.1016\u002Fj.immuni.2017.04.018",{"doi":2503},"10.1016\u002Fj.immuni.2017.04.018",{"id":24,"text":2505,"url":24,"identifiers":2506},"Cros, 2010, Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors, Immunity, 33, 375, 10.1016\u002Fj.immuni.2010.08.012",{"doi":2507},"10.1016\u002Fj.immuni.2010.08.012",{"id":24,"text":2509,"url":24,"identifiers":2510},"Thomas, 2017, Human blood monocyte subsets: a new gating strategy defined using cell surface markers identified by mass cytometry, Arterioscler Thromb Vasc Biol, 37, 1548, 10.1161\u002FATVBAHA.117.309145",{"doi":2511},"10.1161\u002FATVBAHA.117.309145",{"id":24,"text":2513,"url":24,"identifiers":2514},"Jakubzick, 2017, Monocyte differentiation and antigen-presenting functions, Nat Rev Immunol, 2018, 349, 10.1038\u002Fnri.2017.28",{"doi":2515},"10.1038\u002Fnri.2017.28",{"id":24,"text":2517,"url":24,"identifiers":2518},"Briseño, 2016, Distinct transcriptional programs control cross-priming in classical and monocyte-derived dendritic cells, Cell Rep, 15, 2462, 10.1016\u002Fj.celrep.2016.05.025",{"doi":2519},"10.1016\u002Fj.celrep.2016.05.025",{"id":24,"text":2521,"url":24,"identifiers":2522},"Villani, 2017, Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors, Science, 356, eaah4573, 10.1126\u002Fscience.aah4573",{"doi":2523},"10.1126\u002Fscience.aah4573",{"id":24,"text":2525,"url":24,"identifiers":2526},"Menezes, 2016, The heterogeneity of Ly6Chi monocytes controls their differentiation into iNOS+ macrophages or monocyte-derived dendritic cells, Immunity, 45, 1205, 10.1016\u002Fj.immuni.2016.12.001",{"doi":2527},"10.1016\u002Fj.immuni.2016.12.001",{"id":24,"text":2529,"url":24,"identifiers":2530},"Hettinger, 2013, Origin of monocytes and macrophages in a committed progenitor, Nat Immunol, 14, 821, 10.1038\u002Fni.2638",{"doi":2531},"10.1038\u002Fni.2638",{"id":24,"text":2533,"url":24,"identifiers":2534},"Kawamura, 2017, Identification of a human clonogenic progenitor with strict monocyte differentiation potential: a counterpart of mouse cMoPs, Immunity, 46, 835, 10.1016\u002Fj.immuni.2017.04.019",{"doi":2535},"10.1016\u002Fj.immuni.2017.04.019",{"id":24,"text":2537,"url":24,"identifiers":2538},"Zhu, 2016, 2014 Jeffrey M. Hoeg award lecture: transcriptional control of monocyte development, Arterioscler Thromb Vasc Biol, 36, 1722, 10.1161\u002FATVBAHA.116.304054",{"doi":2539},"10.1161\u002FATVBAHA.116.304054",{"id":24,"text":2541,"url":24,"identifiers":2542},"Scott, 1994, Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages, Science, 265, 1573, 10.1126\u002Fscience.8079170",{"doi":2543},"10.1126\u002Fscience.8079170",{"id":24,"text":2545,"url":24,"identifiers":2546},"Kurotaki, 2014, IRF8 inhibits C\u002FEBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils, Nat Commun, 5, 4978, 10.1038\u002Fncomms5978",{"doi":2547},"10.1038\u002Fncomms5978",{"id":24,"text":2549,"url":24,"identifiers":2550},"Kurotaki, 2013, Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation, Blood, 121, 1839, 10.1182\u002Fblood-2012-06-437863",{"doi":2551},"10.1182\u002Fblood-2012-06-437863",{"id":24,"text":2553,"url":24,"identifiers":2554},"Lee, 2015, Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow, J Exp Med, 212, 385, 10.1084\u002Fjem.20141442",{"doi":2555},"10.1084\u002Fjem.20141442",{"id":24,"text":2557,"url":24,"identifiers":2558},"Yáñez, 2017, Granulocyte-Monocyte progenitors and monocyte-dendritic cell progenitors independently produce functionally distinct monocytes, Immunity, 47, 890, 10.1016\u002Fj.immuni.2017.10.021",{"doi":2559},"10.1016\u002Fj.immuni.2017.10.021",{"id":24,"text":2561,"url":24,"identifiers":2562},"Yona, 2013, Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis, Immunity, 38, 79, 10.1016\u002Fj.immuni.2012.12.001",{"doi":2563},"10.1016\u002Fj.immuni.2012.12.001",{"id":24,"text":2565,"url":24,"identifiers":2566},"Varol, 2007, Monocytes give rise to mucosal, but not splenic, conventional dendritic cells, J Exp Med, 204, 171, 10.1084\u002Fjem.20061011",{"doi":2567},"10.1084\u002Fjem.20061011",{"id":24,"text":2569,"url":24,"identifiers":2570},"Patel, 2017, The fate and lifespan of human monocyte subsets in steady state and systemic inflammation, J Exp Med, 214, 1913, 10.1084\u002Fjem.20170355",{"doi":2571},"10.1084\u002Fjem.20170355",{"id":24,"text":2573,"url":24,"identifiers":2574},"Hanna, 2011, The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes, Nat Immunol, 12, 778, 10.1038\u002Fni.2063",{"doi":2575},"10.1038\u002Fni.2063",{"id":24,"text":2577,"url":24,"identifiers":2578},"Thomas, 2016, Deleting an Nr4a1 super-enhancer subdomain ablates Ly6Clow monocytes while preserving macrophage gene function, Immunity, 45, 975, 10.1016\u002Fj.immuni.2016.10.011",{"doi":2579},"10.1016\u002Fj.immuni.2016.10.011",{"id":24,"text":2581,"url":24,"identifiers":2582},"Tamura, 2017, C\u002FEBPβ is required for survival of Ly6C− monocytes, Blood, 130, 1809, 10.1182\u002Fblood-2017-03-772962",{"doi":2583},"10.1182\u002Fblood-2017-03-772962",{"id":24,"text":2585,"url":24,"identifiers":2586},"Gamrekelashvili, 2016, Regulation of monocyte cell fate by blood vessels mediated by Notch signalling, Nat Commun, 7, 12597, 10.1038\u002Fncomms12597",{"doi":2587},"10.1038\u002Fncomms12597",{"id":24,"text":2589,"url":24,"identifiers":2590},"Satoh, 2017, Identification of an atypical monocyte and committed progenitor involved in fibrosis, Nature, 541, 96, 10.1038\u002Fnature20611",{"doi":2591},"10.1038\u002Fnature20611",{"id":24,"text":2593,"url":24,"identifiers":2594},"Serbina, 2006, Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2, Nat Immunol, 7, 311, 10.1038\u002Fni1309",{"doi":2595},"10.1038\u002Fni1309",{"id":24,"text":2597,"url":24,"identifiers":2598},"Jakubzick, 2013, Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes, Immunity, 39, 599, 10.1016\u002Fj.immuni.2013.08.007",{"doi":2599},"10.1016\u002Fj.immuni.2013.08.007",{"id":24,"text":2601,"url":24,"identifiers":2602},"Auffray, 2007, Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior, Science, 317, 666, 10.1126\u002Fscience.1142883",{"doi":2603},"10.1126\u002Fscience.1142883",{"id":24,"text":2605,"url":24,"identifiers":2606},"Debien, 2013, S1PR5 is pivotal for the homeostasis of patrolling monocytes, Eur J Immunol, 43, 1667, 10.1002\u002Feji.201343312",{"doi":2607},"10.1002\u002Feji.201343312",{"id":24,"text":2609,"url":24,"identifiers":2610},"Lavin, 2017, Innate immune landscape in early lung adenocarcinoma by paired single-cell analyses, Cell, 169, 750, 10.1016\u002Fj.cell.2017.04.014",{"doi":2611},"10.1016\u002Fj.cell.2017.04.014",{"id":24,"text":2613,"url":24,"identifiers":2614},"Azizi, 2018, Single-Cell map of diverse immune phenotypes in the breast tumor microenvironment, Cell, 174, 1293, 10.1016\u002Fj.cell.2018.05.060",{"doi":2615},"10.1016\u002Fj.cell.2018.05.060",{"id":24,"text":2617,"url":24,"identifiers":2618},"Jakubzick, 2008, Blood monocyte subsets differentially give rise to CD103+ and CD103− pulmonary dendritic cell populations, J Immunol, 180, 3019, 10.4049\u002Fjimmunol.180.5.3019",{"doi":2619},"10.4049\u002Fjimmunol.180.5.3019",{"id":24,"text":2621,"url":24,"identifiers":2622},"Guilliams, 2014, Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny, Nat Rev Immunol, 14, 571, 10.1038\u002Fnri3712",{"doi":2623},"10.1038\u002Fnri3712",{"id":24,"text":2625,"url":24,"identifiers":2626},"Guilliams, 2017, Does niche competition determine the origin of tissue-resident macrophages?, Nat Rev Immunol, 17, 451, 10.1038\u002Fnri.2017.42",{"doi":2627},"10.1038\u002Fnri.2017.42",{"id":24,"text":2629,"url":24,"identifiers":2630},"van de Laar, 2016, Yolk sac macrophages, fetal liver, and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages, Immunity, 44, 755, 10.1016\u002Fj.immuni.2016.02.017",{"doi":2631},"10.1016\u002Fj.immuni.2016.02.017",{"id":24,"text":2633,"url":24,"identifiers":2634},"Goudot, 2017, Aryl hydrocarbon receptor controls monocyte differentiation into dendritic cells versus macrophages, Immunity, 47, 582, 10.1016\u002Fj.immuni.2017.08.016",{"doi":2635},"10.1016\u002Fj.immuni.2017.08.016",{"id":24,"text":2637,"url":24,"identifiers":2638},"Carlin, 2013, Nr4a1-Dependent Ly6Clow monocytes monitor endothelial cells and orchestrate their disposal, Cell, 153, 362, 10.1016\u002Fj.cell.2013.03.010",{"doi":2639},"10.1016\u002Fj.cell.2013.03.010",{"id":24,"text":2641,"url":24,"identifiers":2642},"Misharin, 2014, Nonclassical Ly6C− monocytes drive the development of inflammatory arthritis in mice, Cell Rep, 9, 591, 10.1016\u002Fj.celrep.2014.09.032",{"doi":2643},"10.1016\u002Fj.celrep.2014.09.032",{"id":24,"text":2645,"url":24,"identifiers":2646},"Olingy, 2017, Non-classical monocytes are biased progenitors of wound healing macrophages during soft tissue injury, Sci Rep, 7, 447, 10.1038\u002Fs41598-017-00477-1",{"doi":2647},"10.1038\u002Fs41598-017-00477-1",{"id":24,"text":2649,"url":24,"identifiers":2650},"Franklin, 2014, The cellular and molecular origin of tumor-associated macrophages, Science, 344, 921, 10.1126\u002Fscience.1252510",{"doi":2651},"10.1126\u002Fscience.1252510",{"id":24,"text":2653,"url":24,"identifiers":2654},"Martinez, 2006, Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: New molecules and patterns of gene expression, J Immunol, 177, 7303, 10.4049\u002Fjimmunol.177.10.7303",{"doi":2655},"10.4049\u002Fjimmunol.177.10.7303",{"id":24,"text":2657,"url":24,"identifiers":2658},"Guilliams, 2018, Developmental and functional heterogeneity of monocytes, Immunity, 49, 595, 10.1016\u002Fj.immuni.2018.10.005",{"doi":2659},"10.1016\u002Fj.immuni.2018.10.005",{"id":24,"text":2661,"url":24,"identifiers":2662},"Movahedi, 2010, Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes, Cancer Res, 70, 5728, 10.1158\u002F0008-5472.CAN-09-4672",{"doi":2663},"10.1158\u002F0008-5472.CAN-09-4672",{"id":24,"text":2665,"url":24,"identifiers":2666},"Kitamura, 2018, Monocytes differentiate to immune suppressive precursors of metastasis-associated macrophages in mouse models of metastatic breast cancer, Front. Immunol., 8, 69, 10.3389\u002Ffimmu.2017.02004",{"doi":2667},"10.3389\u002Ffimmu.2017.02004",{"id":24,"text":2669,"url":24,"identifiers":2670},"Chun, 2015, CCL2 promotes colorectal carcinogenesis by enhancing polymorphonuclear myeloid-derived suppressor cell population and function, Cell Rep, 12, 244, 10.1016\u002Fj.celrep.2015.06.024",{"doi":2671},"10.1016\u002Fj.celrep.2015.06.024",{"id":24,"text":2673,"url":24,"identifiers":2674},"Cortez-Retamozo, 2012, Origins of tumor-associated macrophages and neutrophils, Proc Natl Acad Sci USA, 109, 2491, 10.1073\u002Fpnas.1113744109",{"doi":2675},"10.1073\u002Fpnas.1113744109",{"id":24,"text":2677,"url":24,"identifiers":2678},"Wu, 2018, Spleen mediates a distinct hematopoietic progenitor response supporting tumor-promoting myelopoiesis, J Clin Invest, 128, 3425, 10.1172\u002FJCI97973",{"doi":2679},"10.1172\u002FJCI97973",{"id":24,"text":2681,"url":24,"identifiers":2682},"Shand, 2014, Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes, Proc Natl Acad Sci USA, 111, 7771, 10.1073\u002Fpnas.1402914111",{"doi":2683},"10.1073\u002Fpnas.1402914111",{"id":24,"text":2685,"url":24,"identifiers":2686},"Griffith, 1999, Monocyte-mediated tumoricidal activity via the tumor necrosis factor–related cytokine, TRAIL, J Exp Med, 189, 1343, 10.1084\u002Fjem.189.8.1343",{"doi":2687},"10.1084\u002Fjem.189.8.1343",{"id":24,"text":2689,"url":24,"identifiers":2690},"Hartwig, 2017, The TRAIL-Induced cancer secretome promotes a tumor-supportive immune microenvironment via CCR2, Mol Cell, 65, 730, 10.1016\u002Fj.molcel.2017.01.021",{"doi":2691},"10.1016\u002Fj.molcel.2017.01.021",{"id":24,"text":2693,"url":24,"identifiers":2694},"Gordon, 2006, Defective antitumor function of monocyte-derived macrophages from epithelial ovarian cancer patients, Clin Cancer Res, 12, 1515, 10.1158\u002F1078-0432.CCR-05-2254",{"doi":2695},"10.1158\u002F1078-0432.CCR-05-2254",{"id":24,"text":2697,"url":24,"identifiers":2698},"Yeap, 2016, CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes, Sci Rep, 6, 34310, 10.1038\u002Fsrep34310",{"doi":2699},"10.1038\u002Fsrep34310",{"id":24,"text":2701,"url":24,"identifiers":2702},"Chittezhath, 2014, Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progression, Immunity, 41, 815, 10.1016\u002Fj.immuni.2014.09.014",{"doi":2703},"10.1016\u002Fj.immuni.2014.09.014",{"id":24,"text":2705,"url":24,"identifiers":2706},"Lee, 2012, Protumoral role of monocytes in human B-cell precursor acute lymphoblastic leukemia: involvement of the chemokine CXCL10, Blood, 119, 227, 10.1182\u002Fblood-2011-06-357442",{"doi":2707},"10.1182\u002Fblood-2011-06-357442",{"id":24,"text":2709,"url":24,"identifiers":2710},"Hamm, 2016, Tumour-educated circulating monocytes are powerful candidate biomarkers for diagnosis and disease follow-up of colorectal cancer, Gut, 65, 990, 10.1136\u002Fgutjnl-2014-308988",{"doi":2711},"10.1136\u002Fgutjnl-2014-308988",{"id":24,"text":2713,"url":24,"identifiers":2714},"Headley, 2016, Visualization of immediate immune responses to pioneer metastatic cells in the lung, Nature, 531, 513, 10.1038\u002Fnature16985",{"doi":2715},"10.1038\u002Fnature16985",{"id":24,"text":2717,"url":24,"identifiers":2718},"Jaiswal, 2009, CD47 is up-regulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis, Cell, 138, 271, 10.1016\u002Fj.cell.2009.05.046",{"doi":2719},"10.1016\u002Fj.cell.2009.05.046",{"id":24,"text":2721,"url":24,"identifiers":2722},"Chao, 2010, Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-hodgkin lymphoma, Cell, 142, 699, 10.1016\u002Fj.cell.2010.07.044",{"doi":2723},"10.1016\u002Fj.cell.2010.07.044",{"id":24,"text":2725,"url":24,"identifiers":2726},"Willingham, 2012, The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors, Proc Natl Acad Sci USA, 109, 6662, 10.1073\u002Fpnas.1121623109",{"doi":2727},"10.1073\u002Fpnas.1121623109",{"id":24,"text":2729,"url":24,"identifiers":2730},"Zhao, 2016, CD47 promotes tumor invasion and metastasis in non-small cell lung cancer, Sci Rep, 6, 29719, 10.1038\u002Fsrep29719",{"doi":2731},"10.1038\u002Fsrep29719",{"id":24,"text":2733,"url":24,"identifiers":2734},"Kubo, 2017, Primary tumors limit metastasis formation through induction of IL15-Mediated cross-talk between patrolling monocytes and NK cells, Cancer Immunol Res, 5, 812, 10.1158\u002F2326-6066.CIR-17-0082",{"doi":2735},"10.1158\u002F2326-6066.CIR-17-0082",{"id":24,"text":2737,"url":24,"identifiers":2738},"Plebanek, 2017, Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche, Nat Commun, 8, 1319, 10.1038\u002Fs41467-017-01433-3",{"doi":2739},"10.1038\u002Fs41467-017-01433-3",{"id":24,"text":2741,"url":24,"identifiers":2742},"Veglia, 2018, Myeloid-derived suppressor cells coming of age, Nat Immunol, 19, 108, 10.1038\u002Fs41590-017-0022-x",{"doi":2743},"10.1038\u002Fs41590-017-0022-x",{"id":24,"text":2745,"url":24,"identifiers":2746},"Mitchem, 2012, Targeting tumor-infiltrating macrophages decreases tumor-Initiating cells, relieves immunosuppression and improves chemotherapeutic response, Cancer Res, 73, 2012",{},{"id":24,"text":2748,"url":24,"identifiers":2749},"Li, 2017, Targeting of tumour-infiltrating macrophages via CCL2\u002FCCR2 signalling as a therapeutic strategy against hepatocellular carcinoma, Gut, 66, 157, 10.1136\u002Fgutjnl-2015-310514",{"doi":2750},"10.1136\u002Fgutjnl-2015-310514",{"id":24,"text":2752,"url":24,"identifiers":2753},"Lesokhin, 2012, Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment, Cancer Res, 72, 876, 10.1158\u002F0008-5472.CAN-11-1792",{"doi":2754},"10.1158\u002F0008-5472.CAN-11-1792",{"id":24,"text":2756,"url":24,"identifiers":2757},"Sawanobori, 2008, Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice, Blood, 111, 5457, 10.1182\u002Fblood-2008-01-136895",{"doi":2758},"10.1182\u002Fblood-2008-01-136895",{"id":24,"text":2760,"url":24,"identifiers":2761},"Sanford, 2013, Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2\u002FCCR2 axis, Clin Cancer Res, 19, 3404, 10.1158\u002F1078-0432.CCR-13-0525",{"doi":2762},"10.1158\u002F1078-0432.CCR-13-0525",{"id":24,"text":2764,"url":24,"identifiers":2765},"Weber, 2016, Phase I\u002FII study of metastatic melanoma patients treated with nivolumab who had progressed after ipilimumab, Cancer Immunol Res, 4, 345, 10.1158\u002F2326-6066.CIR-15-0193",{"doi":2766},"10.1158\u002F2326-6066.CIR-15-0193",{"id":24,"text":2768,"url":24,"identifiers":2769},"Schlecker, 2012, Tumor-Infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-Dependent recruitment of regulatory T Cells favoring tumor growth, J Immunol, 189, 5602, 10.4049\u002Fjimmunol.1201018",{"doi":2770},"10.4049\u002Fjimmunol.1201018",{"id":24,"text":2772,"url":24,"identifiers":2773},"Pommier, 2013, Inflammatory monocytes are potent antitumor effectors controlled by regulatory CD4+ T cells, Proc Natl Acad Sci USA, 110, 13085, 10.1073\u002Fpnas.1300314110",{"doi":2774},"10.1073\u002Fpnas.1300314110",{"id":24,"text":2776,"url":24,"identifiers":2777},"Tiemessen, 2007, CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes\u002Fmacrophages, Proc Natl Acad Sci USA, 104, 19446, 10.1073\u002Fpnas.0706832104",{"doi":2778},"10.1073\u002Fpnas.0706832104",{"id":24,"text":2780,"url":24,"identifiers":2781},"Romano, 2015, Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients, Proc Natl Acad Sci USA, 112, 6140, 10.1073\u002Fpnas.1417320112",{"doi":2782},"10.1073\u002Fpnas.1417320112",{"id":24,"text":2784,"url":24,"identifiers":2785},"Kuhn, 2015, Monocyte-Derived dendritic cells are essential for CD8+ T cell activation and antitumor responses after local immunotherapy, Frontiers in Immunology, 6, e17515, 10.3389\u002Ffimmu.2015.00584",{"doi":2786},"10.3389\u002Ffimmu.2015.00584",{"id":24,"text":2788,"url":24,"identifiers":2789},"Sheng, 2017, A discrete subset of monocyte-derived cells among typical conventional type 2 dendritic cells can efficiently cross-present, Cell Rep, 21, 1203, 10.1016\u002Fj.celrep.2017.10.024",{"doi":2790},"10.1016\u002Fj.celrep.2017.10.024",{"id":24,"text":2792,"url":24,"identifiers":2793},"Westhorpe, 2018, Effector CD4 + T cells recognize intravascular antigen presented by patrolling monocytes, Nat Commun, 9, 747, 10.1038\u002Fs41467-018-03181-4",{"doi":2794},"10.1038\u002Fs41467-018-03181-4",{"id":24,"text":2796,"url":24,"identifiers":2797},"Rivera, 2015, Intertwined regulation of angiogenesis and immunity by myeloid cells, Trends Immunol, 36, 240, 10.1016\u002Fj.it.2015.02.005",{"doi":2798},"10.1016\u002Fj.it.2015.02.005",{"id":24,"text":2800,"url":24,"identifiers":2801},"Du, 2008, HIF1α induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion, Cancer Cell, 13, 206, 10.1016\u002Fj.ccr.2008.01.034",{"doi":2802},"10.1016\u002Fj.ccr.2008.01.034",{"id":24,"text":2804,"url":24,"identifiers":2805},"Sidibe, 2018, Angiogenic factor-driven inflammation promotes extravasation of human proangiogenic monocytes to tumours, Nat Commun, 9, 355, 10.1038\u002Fs41467-017-02610-0",{"doi":2806},"10.1038\u002Fs41467-017-02610-0",{"id":24,"text":2808,"url":24,"identifiers":2809},"Zhang, 2010, Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and antiangiogenic effects, Clin Cancer Res, 16, 3420, 10.1158\u002F1078-0432.CCR-09-2904",{"doi":2810},"10.1158\u002F1078-0432.CCR-09-2904",{"id":24,"text":2812,"url":24,"identifiers":2813},"Gazzaniga, 2007, Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft, J Invest Dermatol, 127, 2031, 10.1038\u002Fsj.jid.5700827",{"doi":2814},"10.1038\u002Fsj.jid.5700827",{"id":24,"text":2816,"url":24,"identifiers":2817},"Arwert, 2018, A unidirectional transition from migratory to perivascular macrophage is required for tumor cell intravasation, Cell Rep, 23, 1239, 10.1016\u002Fj.celrep.2018.04.007",{"doi":2818},"10.1016\u002Fj.celrep.2018.04.007",{"id":24,"text":2820,"url":24,"identifiers":2821},"De Palma, 2005, Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors, Cancer Cell, 8, 211, 10.1016\u002Fj.ccr.2005.08.002",{"doi":2822},"10.1016\u002Fj.ccr.2005.08.002",{"id":24,"text":2824,"url":24,"identifiers":2825},"Venneri, 2007, Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer, Blood, 109, 5276, 10.1182\u002Fblood-2006-10-053504",{"doi":2826},"10.1182\u002Fblood-2006-10-053504",{"id":24,"text":2828,"url":24,"identifiers":2829},"Coffelt, 2010, Angiopoietin-2 regulates gene expression in TIE2-Expressing monocytes and augments their inherent proangiogenic functions, Cancer Res, 70, 5270, 10.1158\u002F0008-5472.CAN-10-0012",{"doi":2830},"10.1158\u002F0008-5472.CAN-10-0012",{"id":24,"text":2832,"url":24,"identifiers":2833},"Harney, 2015, Real-Time imaging reveals local, transient vascular permeability, and tumor cell intravasation stimulated by TIE2hi macrophage–derived VEGFA, Cancer Discov, 5, 932, 10.1158\u002F2159-8290.CD-15-0012",{"doi":2834},"10.1158\u002F2159-8290.CD-15-0012",{"id":24,"text":2836,"url":24,"identifiers":2837},"Coffelt, 2011, Angiopoietin 2 stimulates TIE2-Expressing monocytes to suppress T Cell activation and to promote regulatory T cell expansion, J Immunol, 186, 4183, 10.4049\u002Fjimmunol.1002802",{"doi":2838},"10.4049\u002Fjimmunol.1002802",{"id":24,"text":2840,"url":24,"identifiers":2841},"Bergers, 2008, Modes of resistance to anti-angiogenic therapy, Nat Rev Cancer, 8, 592, 10.1038\u002Fnrc2442",{"doi":2842},"10.1038\u002Fnrc2442",{"id":24,"text":2844,"url":24,"identifiers":2845},"Jung, 2017, Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy, J Clin Invest, 127, 3039, 10.1172\u002FJCI93182",{"doi":2846},"10.1172\u002FJCI93182",{"id":24,"text":2848,"url":24,"identifiers":2849},"Xu, 2009, Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1α, CXCR4, CXCL6, and Neuropilin 1 in tumors from patients with rectal cancer, Cancer Res, 69, 7905, 10.1158\u002F0008-5472.CAN-09-2099",{"doi":2850},"10.1158\u002F0008-5472.CAN-09-2099",{"id":24,"text":2852,"url":24,"identifiers":2853},"Shojaei, 2007, Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells, Nat Biotechnol, 25, 911, 10.1038\u002Fnbt1323",{"doi":2854},"10.1038\u002Fnbt1323",{"id":24,"text":2856,"url":24,"identifiers":2857},"Zeisberger, 2006, Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach, Br J Cancer, 95, 272, 10.1038\u002Fsj.bjc.6603240",{"doi":2858},"10.1038\u002Fsj.bjc.6603240",{"id":24,"text":2860,"url":24,"identifiers":2861},"Lu, 2012, The extracellular matrix: a dynamic niche in cancer progression, J Cell Biol, 196, 395, 10.1083\u002Fjcb.201102147",{"doi":2862},"10.1083\u002Fjcb.201102147",{"id":24,"text":2864,"url":24,"identifiers":2865},"Porrello, 2018, Factor XIIIA—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking, Nat Commun, 9, 1988, 10.1038\u002Fs41467-018-04355-w",{"doi":2866},"10.1038\u002Fs41467-018-04355-w",{"id":24,"text":2868,"url":24,"identifiers":2869},"Madsen, 2017, Tumor-associated macrophages derived from circulating inflammatory monocytes degrade collagen through cellular uptake, Cell Rep, 21, 3662, 10.1016\u002Fj.celrep.2017.12.011",{"doi":2870},"10.1016\u002Fj.celrep.2017.12.011",{"id":24,"text":2872,"url":24,"identifiers":2873},"Loyher, 2018, Macrophages of distinct origins contribute to tumor development in the lung, J Exp Med, 87, jem.20180534",{},{"id":24,"text":2875,"url":24,"identifiers":2876},"Lu, 2014, A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages, Nat Cell Biol, 16, 1105, 10.1038\u002Fncb3041",{"doi":2877},"10.1038\u002Fncb3041",{"id":24,"text":2879,"url":24,"identifiers":2880},"Lapenna, 2018, Perivascular macrophages in health and disease, Nat Rev Immunol, 2018, 689, 10.1038\u002Fs41577-018-0056-9",{"doi":2881},"10.1038\u002Fs41577-018-0056-9",{"id":24,"text":2883,"url":24,"identifiers":2884},"Forssell, 2007, High macrophage infiltration along the tumor front correlates with improved survival in colon cancer, Clin Cancer Res, 13, 1472, 10.1158\u002F1078-0432.CCR-06-2073",{"doi":2885},"10.1158\u002F1078-0432.CCR-06-2073",{"id":24,"text":2887,"url":24,"identifiers":2888},"Noy, 2014, Tumor-Associated macrophages: from mechanisms to therapy, Immunity, 41, 49, 10.1016\u002Fj.immuni.2014.06.010",{"doi":2889},"10.1016\u002Fj.immuni.2014.06.010",{"id":24,"text":2891,"url":24,"identifiers":2892},"Mantovani, 2017, Tumour-associated macrophages as treatment targets in oncology, Nat Rev Clin Oncol, 14, 399, 10.1038\u002Fnrclinonc.2016.217",{"doi":2893},"10.1038\u002Fnrclinonc.2016.217",{"id":24,"text":2895,"url":24,"identifiers":2896},"Broz, 2014, Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity, Cancer Cell, 26, 638, 10.1016\u002Fj.ccell.2014.09.007",{"doi":2897},"10.1016\u002Fj.ccell.2014.09.007",{"id":24,"text":2899,"url":24,"identifiers":2900},"Sharma, 2018, Activation of p53 in immature myeloid precursor cells controls differentiation into Ly6c+CD103+ monocytic antigen-presenting cells in tumors, Immunity, 48, 91, 10.1016\u002Fj.immuni.2017.12.014",{"doi":2901},"10.1016\u002Fj.immuni.2017.12.014",{"id":24,"text":2903,"url":24,"identifiers":2904},"Wilcox, 2011, The absolute monocyte and lymphocyte prognostic score predicts survival and identifies high-risk patients in diffuse large-B-cell lymphoma, Leukemia, 25, 1502, 10.1038\u002Fleu.2011.112",{"doi":2905},"10.1038\u002Fleu.2011.112",{"id":24,"text":2907,"url":24,"identifiers":2908},"Lee, 2012, Prognostic value of pre-treatment circulating monocyte count in patients with cervical cancer: comparison with SCC-Ag level, Gynecol Oncol, 124, 92, 10.1016\u002Fj.ygyno.2011.09.034",{"doi":2909},"10.1016\u002Fj.ygyno.2011.09.034",{"id":24,"text":2911,"url":24,"identifiers":2912},"Li, 2012, Blood lymphocyte-to-monocyte ratio identifies high-risk patients in diffuse large B-cell lymphoma treated with R-CHOP, PLoS One, 7, e41658, 10.1371\u002Fjournal.pone.0041658",{"doi":2913},"10.1371\u002Fjournal.pone.0041658",{"id":24,"text":2915,"url":24,"identifiers":2916},"Stotz, 2014, The preoperative lymphocyte to monocyte ratio predicts clinical outcome in patients with stage III colon cancer, Br J Cancer, 110, 435, 10.1038\u002Fbjc.2013.785",{"doi":2917},"10.1038\u002Fbjc.2013.785",{"id":24,"text":2919,"url":24,"identifiers":2920},"Hu, 2014, Prognostic significance of systemic inflammation-based lymphocyte- monocyte ratio in patients with lung cancer: based on a large cohort study, PLoS One, 9, e108062, 10.1371\u002Fjournal.pone.0108062",{"doi":2921},"10.1371\u002Fjournal.pone.0108062",{"id":24,"text":2923,"url":24,"identifiers":2924},"Eo, 2016, The lymphocyte-monocyte ratio predicts patient survival and aggressiveness of ovarian cancer, J Cancer, 7, 289, 10.7150\u002Fjca.13432",{"doi":2925},"10.7150\u002Fjca.13432",{"id":24,"text":2927,"url":24,"identifiers":2928},"Lu, 2007, CCR2 expression correlates with prostate cancer progression, J Cell Biochem, 101, 676, 10.1002\u002Fjcb.21220",{"doi":2929},"10.1002\u002Fjcb.21220",{"id":24,"text":2931,"url":24,"identifiers":2932},"Krieg, 2018, High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy, Nat Med, 9, 2579",{},{"id":24,"text":2934,"url":24,"identifiers":2935},"Schmall, 2015, Macrophage and cancer cell cross-talk via CCR2 and CX3CR1 is a fundamental mechanism driving lung cancer, Am J Respir Crit Care Med, 191, 437, 10.1164\u002Frccm.201406-1137OC",{"doi":2936},"10.1164\u002Frccm.201406-1137OC",{"id":24,"text":2938,"url":24,"identifiers":2939},"Loberg, 2007, Targeting CCL2 with systemic delivery of neutralizing antibodies induces prostate cancer tumor regression in vivo, Cancer Res, 67, 9417, 10.1158\u002F0008-5472.CAN-07-1286",{"doi":2940},"10.1158\u002F0008-5472.CAN-07-1286",{"id":24,"text":2942,"url":24,"identifiers":2943},"Leuschner, 2011, Therapeutic siRNA silencing in inflammatory monocytes in mice, Nat Biotechnol, 29, 1005, 10.1038\u002Fnbt.1989",{"doi":2944},"10.1038\u002Fnbt.1989",{"id":24,"text":2946,"url":24,"identifiers":2947},"Pienta, 2012, Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer, Invest New Drugs, 31, 760, 10.1007\u002Fs10637-012-9869-8",{"doi":2948},"10.1007\u002Fs10637-012-9869-8",{"id":24,"text":2950,"url":24,"identifiers":2951},"Nywening, 2016, Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial, Lancet Oncol, 17, 651, 10.1016\u002FS1470-2045(16)00078-4",{"doi":2952},"10.1016\u002FS1470-2045(16)00078-4",{"id":24,"text":2954,"url":24,"identifiers":2955},"Bonapace, 2014, Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis, Nature, 515, 130, 10.1038\u002Fnature13862",{"doi":2956},"10.1038\u002Fnature13862",{"id":24,"text":2958,"url":24,"identifiers":2959},"Yu, 2007, Defective antitumor responses in CX3CR1-deficient mice, Int J Cancer, 121, 316, 10.1002\u002Fijc.22660",{"doi":2960},"10.1002\u002Fijc.22660",{"id":24,"text":2962,"url":24,"identifiers":2963},"Hyakudomi, 2008, Increased expression of fractalkine is correlated with a better prognosis and an increased number of both CD8+ T cells and natural killer cells in gastric adenocarcinoma, Ann Surg Oncol, 15, 1775, 10.1245\u002Fs10434-008-9876-3",{"doi":2964},"10.1245\u002Fs10434-008-9876-3",{"id":24,"text":2966,"url":24,"identifiers":2967},"Park, 2012, High expression of CX3CL1 by tumor cells correlates with a good prognosis and increased tumor-infiltrating CD8+ T cells, natural killer cells, and dendritic cells in breast carcinoma, J Surg Oncol, 106, 386, 10.1002\u002Fjso.23095",{"doi":2968},"10.1002\u002Fjso.23095",{"id":24,"text":2970,"url":24,"identifiers":2971},"Jung, 2017, Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer, Proc Natl Acad Sci USA, 114, 10455, 10.1073\u002Fpnas.1710754114",{"doi":2972},"10.1073\u002Fpnas.1710754114",{"id":24,"text":2974,"url":24,"identifiers":2975},"Welford, 2011, TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice, J Clin Invest, 121, 1969, 10.1172\u002FJCI44562",{"doi":2976},"10.1172\u002FJCI44562",{"id":24,"text":2978,"url":24,"identifiers":2979},"Van Overmeire, 2016, M-CSF and GM-CSF receptor signaling differentially regulate monocyte maturation and macrophage polarization in the tumor microenvironment, Cancer Res, 76, 35, 10.1158\u002F0008-5472.CAN-15-0869",{"doi":2980},"10.1158\u002F0008-5472.CAN-15-0869",{"id":24,"text":2982,"url":24,"identifiers":2983},"Cannarile, 2017, Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy, J Immunother Cancer, 5, 705, 10.1186\u002Fs40425-017-0257-y",{"doi":2984},"10.1186\u002Fs40425-017-0257-y",{"id":24,"text":2986,"url":24,"identifiers":2987},"Aharinejad, 2004, Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice, Cancer Res, 64, 5378, 10.1158\u002F0008-5472.CAN-04-0961",{"doi":2988},"10.1158\u002F0008-5472.CAN-04-0961",{"id":24,"text":2990,"url":24,"identifiers":2991},"DeNardo, 2011, Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy, Cancer Discov, 1, 54, 10.1158\u002F2159-8274.CD-10-0028",{"doi":2992},"10.1158\u002F2159-8274.CD-10-0028",{"id":24,"text":2994,"url":24,"identifiers":2995},"Pyonteck, 2013, CSF-1R inhibition alters macrophage polarization and blocks glioma progression, Nat Med, 2018, 1264, 10.1038\u002Fnm.3337",{"doi":2996},"10.1038\u002Fnm.3337",{"id":24,"text":2998,"url":24,"identifiers":2999},"Ries, 2014, Targeting tumor-associated macrophages with Anti-CSF-1R antibody reveals a strategy for cancer therapy, Cancer Cell, 25, 846, 10.1016\u002Fj.ccr.2014.05.016",{"doi":3000},"10.1016\u002Fj.ccr.2014.05.016",{"id":24,"text":3002,"url":24,"identifiers":3003},"Neubert, 2018, T cell-induced CSF1 promotes melanoma resistance to PD1 blockade, Sci Transl Med, 10, 10.1126\u002Fscitranslmed.aan3311",{"doi":3004},"10.1126\u002Fscitranslmed.aan3311",{"id":24,"text":3006,"url":24,"identifiers":3007},"Zhu, 2014, CSF1\u002FCSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models, Cancer Res, 74, 5057, 10.1158\u002F0008-5472.CAN-13-3723",{"doi":3008},"10.1158\u002F0008-5472.CAN-13-3723",{"id":24,"text":3010,"url":24,"identifiers":3011},"Beffinger, 2018, CSF1R-dependent myeloid cells are required for NK-mediated control of metastasis, JCI Insight, 3, 97792, 10.1172\u002Fjci.insight.97792",{"doi":3012},"10.1172\u002Fjci.insight.97792",{"id":24,"text":3014,"url":24,"identifiers":3015},"Quail, 2016, The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas, Science, 352, aad3018, 10.1126\u002Fscience.aad3018",{"doi":3016},"10.1126\u002Fscience.aad3018",{"id":24,"text":3018,"url":24,"identifiers":3019},"Kumar, 2017, Cancer-Associated fibroblasts neutralize the anti-tumor effect of CSF1 receptor blockade by inducing PMN-MDSC infiltration of tumors, Cancer Cell, 32, 654, 10.1016\u002Fj.ccell.2017.10.005",{"doi":3020},"10.1016\u002Fj.ccell.2017.10.005",{"id":24,"text":3022,"url":24,"identifiers":3023},"June, 2018, Chimeric antigen receptor therapy, N Engl J Med, 379, 64, 10.1056\u002FNEJMra1706169",{"doi":3024},"10.1056\u002FNEJMra1706169",{"id":24,"text":3026,"url":24,"identifiers":3027},"Green, 2018, A phase 1 trial of autologous monocytes stimulated ex vivo with Sylatron ® (peginterferon alfa-2b) and Actimmune ® (interferon gamma-1b) for intra-peritoneal administration in recurrent ovarian cancer, J. Transl. Med., 16, 196, 10.1186\u002Fs12967-018-1569-5",{"doi":3028},"10.1186\u002Fs12967-018-1569-5",{"id":24,"text":3030,"url":24,"identifiers":3031},"Norelli, 2018, Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells, Nat Med, 118, 1",{},{"id":24,"text":3033,"url":24,"identifiers":3034},"Long, 2016, Reduction of MDSCs with all-trans retinoic acid improves CAR therapy efficacy for sarcomas, Cancer Immunol Res, 4, 869, 10.1158\u002F2326-6066.CIR-15-0230",{"doi":3035},"10.1158\u002F2326-6066.CIR-15-0230",{"id":24,"text":3037,"url":24,"identifiers":3038},"Dietrich, 2018, Bone marrow drives central nervous system regeneration after radiation injury, J Clin Invest, 128, 281, 10.1172\u002FJCI90647",{"doi":3039},"10.1172\u002FJCI90647",{"id":3041,"createTime":3042,"updateTime":3042,"relativeEntities":3043,"slug":3044,"properties":3045,"entityType":143,"verifyStatus":144,"verifyTime":3042,"verifyNote":146,"syncStatus":23,"languages":3059,"translateLanguages":24,"viewCount":25,"primaryUrl":3060,"fullTextUrl":24,"authors":3061,"publicationType":207,"publisherRelationship":3201,"citationCount":3233,"citationInfo":3234,"publishDate":3237,"publishYear":3238,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":3239,"isForceReanalyzing":258},"860890c6-d9ff-4837-8347-e23090724f8e","2024-09-24T22:51:34.353+00:00",[],"Endothelins-modulate-inflammatory-reaction-in-zymosan-induced-arthritis-participation-of-LTB4-TNF-%CE%B1-and-CXCL-1",{"mag":3046,"keywords":3048,"openalex":3049,"abstract":3051,"title":3053,"pm":3055,"doi":3057},{"VOID":3047},"2095952820",{},{"VOID":3050},"W2095952820",{"EN":3052},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Endothelins (ETs) are involved in inflammatory events, including pain, fever, edema, and cell migration. ET-1 levels are increased in plasma and synovial membrane of rheumatoid arthritis (RA) patients, but the evidence that ETs participate in RA physiopathology is limited. The present study investigated the involvement of ETs in neutrophil accumulation and edema formation in the murine model of zymosan-induced arthritis. Intra-articular (i.a.) administration of selective ETA or ETB receptor antagonists (BQ-123 and BQ-788, respectively; 15 pmol\u002Fcavity) prior to i.a. zymosan injection (500 μg\u002Fcavity) markedly reduced knee-joint edema formation and neutrophil influx to the synovial cavity 6 h and 24 h after stimulation. Histological analysis showed that ETA or ETB receptor blockade suppressed zymosan-induced neutrophil accumulation in articular tissue at 6 h. Likewise, dual blockade of ETA\u002FETB with bosentan (10 mg\u002Fkg, i.v.) also reduced edema formation and neutrophil counts 6 h after zymosan stimulation. Pretreatment with BQ-123 or BQ-788 (i.a.; 15 pmol\u002Fcavity) also decreased zymosan-induced TNF-α production within 6 h, keratinocyte-derived chemokine\u002FCXCL1 production within 24 h, and leukotriene B4 at both time-points. Consistent with the demonstration that ET receptor antagonists inhibit zymosan-induced inflammation, i.a. injection of ET-1 (1–30 pmol\u002Fcavity) or sarafotoxin S6c (0.1–30 pmol\u002Fcavity) also triggered edema formation and neutrophil accumulation within 6 h. Moreover, knee-joint synovial tissue expressed ETA and ETB receptors. These findings suggest that endogenous ETs contribute to knee-joint inflammation, acting through ETA and ETB receptors and modulating edema formation, neutrophil recruitment, and production of inflammatory mediators.\u003C\u002Fjats:p>",{"EN":3054},"Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-α, and CXCL-1",{"VOID":3056},"18515326",{"VOID":3058},"10.1189\u002Fjlb.1207827",[148],"https:\u002F\u002Facademic.oup.com\u002Fjleukbio\u002Farticle\u002F84\u002F3\u002F652\u002F6975228",[3062,3084,3106,3128,3150,3167,3184],{"id":3063,"sortIndex":353,"researcher":24,"roles":3064,"affiliations":3065,"properties":3077},"da639ab9-3b6c-49f5-8e8a-803ea17609fd",[],[3066],{"id":3067,"sortIndex":25,"affiliation":3068,"properties":24},"bec2cb0b-071a-4af6-8b94-4d15d25db195",{"id":3069,"createTime":3070,"updateTime":3071,"relativeEntities":3072,"slug":3073,"properties":3074,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"47dbd90f-8417-42ff-81a9-5cd880d47845","2023-11-24T15:14:49.439+00:00","2024-09-24T22:51:34.388+00:00",[],"Departamento-de-Farmacologia-Faculdade-de-Medicina-de-Ribeir%C3%A3o-Preto-Universidade-de-S%C3%A3o-Paulo-Ribeir%C3%A3o-Preto-Brazil",{"title":3075},{"VI":3076},"Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil",{"openalex":3078,"orcid":3080,"title":3082},{"VOID":3079},"A5050684767",{"VOID":3081},"https:\u002F\u002Forcid.org\u002F0000-0003-4755-1670",{"EN":3083},"Fernando Q. 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Natl. Acad. Sci. USA, 86, 2863, 10.1073\u002Fpnas.86.8.2863",{"doi":3243},"10.1073\u002Fpnas.86.8.2863",{"id":24,"text":3245,"url":24,"identifiers":3246},"Bdolah, 1989, SRTX-d, a new native peptide of the endothelin\u002Fsarafotoxin family, FEBS Lett., 256, 1, 10.1016\u002F0014-5793(89)81706-5",{"doi":3247},"10.1016\u002F0014-5793(89)81706-5",{"id":24,"text":3249,"url":24,"identifiers":3250},"Arai, 1990, Cloning and expression of a cDNA encoding an endothelin receptor, Nature, 348, 730, 10.1038\u002F348730a0",{"doi":3251},"10.1038\u002F348730a0",{"id":24,"text":3253,"url":24,"identifiers":3254},"Sakurai, 1990, Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor, Nature, 348, 732, 10.1038\u002F348732a0",{"doi":3255},"10.1038\u002F348732a0",{"id":24,"text":3257,"url":24,"identifiers":3258},"Davenport, 2006, Endothelin, Handb. Exp. Pharmacol., 2006, 295, 10.1007\u002F3-540-32967-6_9",{"doi":3259},"10.1007\u002F3-540-32967-6_9",{"id":24,"text":3261,"url":24,"identifiers":3262},"Shah, 2007, Endothelins in health and disease, Eur. J. Intern. Med., 18, 272, 10.1016\u002Fj.ejim.2007.04.002",{"doi":3263},"10.1016\u002Fj.ejim.2007.04.002",{"id":24,"text":3265,"url":24,"identifiers":3266},"Schwarting, 1996, Endothelin-1 modulates the expression of adhesion molecules on fibroblast-like synovial cells (FLS), Scand. J. Rheumatol., 25, 246, 10.3109\u002F03009749609069994",{"doi":3267},"10.3109\u002F03009749609069994",{"id":24,"text":3269,"url":24,"identifiers":3270},"Filep, 1993, Enhancement by endothelin-1 of microvascular permeability via the activation of ETA receptors, Br. J. Pharmacol., 109, 880, 10.1111\u002Fj.1476-5381.1993.tb13657.x",{"doi":3271},"10.1111\u002Fj.1476-5381.1993.tb13657.x",{"id":24,"text":3273,"url":24,"identifiers":3274},"Sampaio, 2000, Participation of endogenous endothelins in delayed eosinophil and neutrophil recruitment in mouse pleurisy, Inflamm. Res., 49, 170, 10.1007\u002Fs000110050577",{"doi":3275},"10.1007\u002Fs000110050577",{"id":24,"text":3277,"url":24,"identifiers":3278},"Speciale, 1998, Different endothelins stimulate cytokine production by peritoneal macrophages and microglial cell line, Immunology, 93, 109, 10.1046\u002Fj.1365-2567.1998.00391.x",{"doi":3279},"10.1046\u002Fj.1365-2567.1998.00391.x",{"id":24,"text":3281,"url":24,"identifiers":3282},"Sampaio, 2000, Role of endothelins on lymphocyte accumulation in allergy, J. Leukoc. Biol., 67, 189, 10.1002\u002Fjlb.67.2.189",{"doi":3283},"10.1002\u002Fjlb.67.2.189",{"id":24,"text":3285,"url":24,"identifiers":3286},"Zouki, 1999, Endothelin-1 enhances neutrophil adhesion to human coronary artery endothelial cells: role of ET(A) receptors and platelet-activating factor, Br. J. Pharmacol., 127, 969, 10.1038\u002Fsj.bjp.0702593",{"doi":3287},"10.1038\u002Fsj.bjp.0702593",{"id":24,"text":3289,"url":24,"identifiers":3290},"Goronzy, 2005, Rheumatoid arthritis, Immunol. Rev., 204, 55, 10.1111\u002Fj.0105-2896.2005.00245.x",{"doi":3291},"10.1111\u002Fj.0105-2896.2005.00245.x",{"id":24,"text":3293,"url":24,"identifiers":3294},"Kuryliszyn-Moskal, 2006, A study on vascular endothelial growth factor and endothelin-1 in patients with extra-articular involvement of rheumatoid arthritis, Clin. Rheumatol., 25, 314, 10.1007\u002Fs10067-005-0007-2",{"doi":3295},"10.1007\u002Fs10067-005-0007-2",{"id":24,"text":3297,"url":24,"identifiers":3298},"Haq, 1999, Serum and synovial fluid concentrations of endothelin-1 in patients with rheumatoid arthritis, J. Med., 30, 51",{},{"id":24,"text":3300,"url":24,"identifiers":3301},"Vaudo, 2004, Endothelial dysfunction in young patients with rheumatoid arthritis and low disease activity, Ann. Rheum. Dis., 63, 31, 10.1136\u002Fard.2003.007740",{"doi":3302},"10.1136\u002Fard.2003.007740",{"id":24,"text":3304,"url":24,"identifiers":3305},"Andersson, 1999, Periarticular tissue levels of cytokine- and endothelin-1-like immunoreactivity during the course of antigen-induced arthritis in the rat, Inflamm. Res., 48, 491, 10.1007\u002Fs000110050492",{"doi":3306},"10.1007\u002Fs000110050492",{"id":24,"text":3308,"url":24,"identifiers":3309},"Penido, 2006, Antiinflammatory effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on zymosan-induced arthritis in mice, Inflamm. Res., 55, 457, 10.1007\u002Fs00011-006-5161-8",{"doi":3310},"10.1007\u002Fs00011-006-5161-8",{"id":24,"text":3312,"url":24,"identifiers":3313},"Verri, 2008, IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice, Proc. Natl. Acad. Sci. USA, 105, 2723, 10.1073\u002Fpnas.0712116105",{"doi":3314},"10.1073\u002Fpnas.0712116105",{"id":24,"text":3316,"url":24,"identifiers":3317},"Verri, 2006, IL-15 mediates immune inflammatory hypernociception by triggering a sequential release of IFN-γ, endothelin, and prostaglandin, Proc. Natl. Acad. Sci. USA, 103, 9721, 10.1073\u002Fpnas.0603286103",{"doi":3318},"10.1073\u002Fpnas.0603286103",{"id":24,"text":3320,"url":24,"identifiers":3321},"Meuser-Batista, 2008, Tissue Cell",{},{"id":24,"text":3323,"url":24,"identifiers":3324},"Rosengren, 2003, Measurement of inflammatory biomarkers in synovial tissue extracts by enzyme-linked immunosorbent assay, Clin. Diagn. Lab. Immunol., 10, 1002",{},{"id":24,"text":3326,"url":24,"identifiers":3327},"Van Meurs, 1997, Quantification of mRNA levels in joint capsule and articular cartilage of the murine knee joint by RT-PCR: kinetics of stromelysin and IL-1 mRNA levels during arthritis, Rheumatol. Int., 16, 197, 10.1007\u002FBF01330296",{"doi":3328},"10.1007\u002FBF01330296",{"id":24,"text":3330,"url":24,"identifiers":3331},"Miyasaka, 1992, Increased production of endothelin-1 in patients with inflammatory arthritides, Arthritis Rheum., 35, 397, 10.1002\u002Fart.1780350406",{"doi":3332},"10.1002\u002Fart.1780350406",{"id":24,"text":3334,"url":24,"identifiers":3335},"Rocha, 1999, Periarthritis promotes gait disturbance in zymosan-induced arthritis in rats, Inflamm. Res., 48, 485, 10.1007\u002Fs000110050491",{"doi":3336},"10.1007\u002Fs000110050491",{"id":24,"text":3338,"url":24,"identifiers":3339},"Sampaio, 2004, Effects of endothelin ETA receptor antagonism on granulocyte and lymphocyte accumulation in LPS-induced inflammation, J. Leukoc. Biol., 76, 210, 10.1189\u002Fjlb.1003504",{"doi":3340},"10.1189\u002Fjlb.1003504",{"id":24,"text":3342,"url":24,"identifiers":3343},"Piovezan, 1997, Endothelins potentiate formalin-induced nociception and paw edema in mice, Can. J. Physiol. Pharmacol., 75, 596, 10.1139\u002Fy97-057",{"doi":3344},"10.1139\u002Fy97-057",{"id":24,"text":3346,"url":24,"identifiers":3347},"Yuyama, 2004, Inhibitory effects of a selective endothelin-A receptor antagonist YM598 on endothelin-1-induced potentiation of nociception in formalin-induced and prostate cancer-induced pain models in mice, J. Cardiovasc. Pharmacol., 44, S479, 10.1097\u002F01.fjc.0000166309.63808.5f",{"doi":3348},"10.1097\u002F01.fjc.0000166309.63808.5f",{"id":24,"text":3350,"url":24,"identifiers":3351},"Sampaio, 1995, ETA receptor antagonists inhibit allergic inflammation in the mouse, J. Cardiovasc. Pharmacol., 26, S416, 10.1097\u002F00005344-199526003-00122",{"doi":3352},"10.1097\u002F00005344-199526003-00122",{"id":24,"text":3354,"url":24,"identifiers":3355},"Khatib, 1997, The mechanism of inhibition of endothelin-1-induced stimulation of DNA synthesis in rat articular chondrocytes, Mol. Cell. Endocrinol., 132, 25, 10.1016\u002FS0303-7207(97)00121-4",{"doi":3356},"10.1016\u002FS0303-7207(97)00121-4",{"id":24,"text":3358,"url":24,"identifiers":3359},"Yoshida, 1998, Endothelin-1 production by human synoviocytes, Ann. Clin. Biochem., 35, 290, 10.1177\u002F000456329803500215",{"doi":3360},"10.1177\u002F000456329803500215",{"id":24,"text":3362,"url":24,"identifiers":3363},"Wharton, 1992, Autoradiographic localization and analysis of endothelin-1 binding sites in human synovial tissue, Arthritis Rheum., 35, 894, 10.1002\u002Fart.1780350807",{"doi":3364},"10.1002\u002Fart.1780350807",{"id":24,"text":3366,"url":24,"identifiers":3367},"Hültner, 2005, Mast cells and endothelin-1: a life-saving biological liaison?, Trends Immunol., 26, 235, 10.1016\u002Fj.it.2005.03.007",{"doi":3368},"10.1016\u002Fj.it.2005.03.007",{"id":24,"text":3370,"url":24,"identifiers":3371},"Maurer, 2004, Mast cells promote homeostasis by limiting endothelin-1-induced toxicity, Nature, 432, 512, 10.1038\u002Fnature03085",{"doi":3372},"10.1038\u002Fnature03085",{"id":24,"text":3374,"url":24,"identifiers":3375},"Metz, 2006, Inflammatory murine skin responses to UV-B light are partially dependent on endothelin-1 and mast cells, Am. J. Pathol., 169, 815, 10.2353\u002Fajpath.2006.060037",{"doi":3376},"10.2353\u002Fajpath.2006.060037",{"id":24,"text":3378,"url":24,"identifiers":3379},"Nigrovic, 2007, Synovial mast cells: role in acute and chronic arthritis, Immunol. Rev., 217, 19, 10.1111\u002Fj.1600-065X.2007.00506.x",{"doi":3380},"10.1111\u002Fj.1600-065X.2007.00506.x",{"id":24,"text":3382,"url":24,"identifiers":3383},"Eklund, 2007, Mast cells in the pathogenesis of rheumatic diseases and as potential targets for anti-rheumatic therapy, Immunol. Rev., 217, 38, 10.1111\u002Fj.1600-065X.2007.00504.x",{"doi":3384},"10.1111\u002Fj.1600-065X.2007.00504.x",{"id":24,"text":3386,"url":24,"identifiers":3387},"Cronstein, 2006, The inflammatory process of gout and its treatment, Arthritis Res. Ther., 8",{},{"id":24,"text":3389,"url":24,"identifiers":3390},"Bombini, 2004, Tumor necrosis factor-α mediates neutrophil migration to the knee synovial cavity during immune inflammation, Eur. J. Pharmacol., 496, 197, 10.1016\u002Fj.ejphar.2004.06.003",{"doi":3391},"10.1016\u002Fj.ejphar.2004.06.003",{"id":24,"text":3393,"url":24,"identifiers":3394},"Lipsky, 2000, Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study group, N. Engl. J. Med., 343, 1594, 10.1056\u002FNEJM200011303432202",{"doi":3395},"10.1056\u002FNEJM200011303432202",{"id":24,"text":3397,"url":24,"identifiers":3398},"Kim, 2006, A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis, J. Exp. Med., 203, 829, 10.1084\u002Fjem.20052349",{"doi":3399},"10.1084\u002Fjem.20052349",{"id":24,"text":3401,"url":24,"identifiers":3402},"Guerrero, 2008, Involvement of LTB4 in zymosan-induced joint nociception in mice: participation of neutrophils and PGE2, J. Leukoc. Biol., 83, 122, 10.1189\u002Fjlb.0207123",{"doi":3403},"10.1189\u002Fjlb.0207123",{"id":24,"text":3405,"url":24,"identifiers":3406},"Shao, 2006, Targeted disruption of leukotriene B4 receptors BLT1 and BLT2: a critical role for BLT1 in collagen-induced arthritis in mice, J. Immunol., 176, 6254, 10.4049\u002Fjimmunol.176.10.6254",{"doi":3407},"10.4049\u002Fjimmunol.176.10.6254",{"id":24,"text":3409,"url":24,"identifiers":3410},"Hata, 2004, Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice, J. Clin. Invest., 114, 582, 10.1172\u002FJCI200421795",{"doi":3411},"10.1172\u002FJCI200421795",{"id":24,"text":3413,"url":24,"identifiers":3414},"Van de Loo, 1995, Role of interleukin-1, tumor necrosis factor α, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis, Arthritis Rheum., 38, 164, 10.1002\u002Fart.1780380204",{"doi":3415},"10.1002\u002Fart.1780380204",{"id":24,"text":3417,"url":24,"identifiers":3418},"Vale, 2004, Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain, Br. J. Pharmacol., 143, 833, 10.1038\u002Fsj.bjp.0705999",{"doi":3419},"10.1038\u002Fsj.bjp.0705999",{"id":24,"text":3421,"url":24,"identifiers":3422},"Vale, 2006, Anti-nociceptive effect of thalidomide on zymosan-induced experimental articular incapacitation, Eur. J. Pharmacol., 536, 309, 10.1016\u002Fj.ejphar.2006.02.051",{"doi":3423},"10.1016\u002Fj.ejphar.2006.02.051",{"id":24,"text":3425,"url":24,"identifiers":3426},"Elferink, 1994, Endothelin-induced activation of neutrophil migration, Biochem. Pharmacol., 48, 865, 10.1016\u002F0006-2952(94)90356-5",{"doi":3427},"10.1016\u002F0006-2952(94)90356-5"]