[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_96a941dc-874d-4a94-bffb-b68e35cb085e":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:96a941dc-874d-4a94-bffb-b68e35cb085e,\"}":270},{"code":4,"data":5,"meta":24},"SUCCESS",{"id":6,"createTime":7,"updateTime":8,"relativeEntities":9,"slug":10,"properties":11,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":26,"manageAffiliations":39,"indexDatabases":54,"url":90,"thumbnailPath":24,"statistic":91,"gsStatistic":24,"type":24,"analyzePriority":24},"96a941dc-874d-4a94-bffb-b68e35cb085e","2023-05-29T11:03:45.130+00:00","2025-11-21T09:54:06.998+00:00",[],"Journal-of-Immunology",{"country":12,"eissn":14,"issn":16,"title":18,"introduce":20},{"VOID":13},"US",{"VOID":15},"00221767",{"VOID":17},"15506606",{"EN":19},"Journal of Immunology",{"EN":21},"The Journal of Immunology (The JI) publishes novel, peer-reviewed findings in all areas of experimental immunology, including innate and adaptive immunity, inflammation, host defense, clinical immunology, autoimmunity and more.","PUBLISHER","PENDING",null,0,[27,33],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":29,"label":30,"description":32,"parentId":24,"standard":24,"scholarHubFieldId":24},"b2f3603d-283c-49e1-a8f1-01f0de24243c",[],{"EN":31},"Immunology",{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":35,"label":36,"description":38,"parentId":24,"standard":24,"scholarHubFieldId":24},"6dc081f7-79a9-45f6-8ed3-54ef5518db41",[],{"EN":37},"Immunology and Allergy",{},[40,47],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":42,"slug":24,"properties":43,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":46,"statistic":24},"12b5da44-ba9c-4ca2-8dc7-3ff0caa3a8ba",[],{"title":44},{"EN":45},"American Association of Immunologists",[],{"id":48,"createTime":24,"updateTime":24,"relativeEntities":49,"slug":24,"properties":50,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":53,"statistic":24},"70847b97-39f7-49b9-b5ee-bfccdfc691fc",[],{"title":51},{"EN":52},"AMER ASSOC IMMUNOLOGISTS",[],[55,72],{"id":56,"indexDatabase":57,"url":69,"indexYears":24,"academicFieldIds":70,"indexDatabaseRanking":24},"a66ddfdf-52cd-4c9f-beee-8c7094354952",{"id":58,"createTime":24,"updateTime":24,"relativeEntities":59,"label":60,"description":62,"key":65,"publicationTags":66,"standard":24},"a4921856-b128-4d9f-8f1f-e80813d3bbd4",[],{"EN":61,"VI":61},"ISI\u002FSCIE - Science Citation Index Expanded",{"EN":63,"VI":64},"SCIE database","Cơ sở dữ liệu SCIE","scie",[67,68],"SCIE","ISI","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=0022-1767",[71],"03744874-dcbd-436b-8d5c-f6fa955ce005",{"id":73,"indexDatabase":74,"url":84,"indexYears":85,"academicFieldIds":86,"indexDatabaseRanking":89},"f36b052e-df6d-4b6c-9fb5-56992bf38382",{"id":75,"createTime":24,"updateTime":24,"relativeEntities":76,"label":77,"description":79,"key":81,"publicationTags":82,"standard":24},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9",[],{"EN":78,"VI":78},"Scopus - Elsevier",{"EN":78,"VI":80},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[83],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F21275","1945-2025",[87,88],"2e85ca04-4b9c-4f3e-be83-f6e278d9077d","e872d6d8-194c-4b83-9ea3-8b78dd28210d","SCOPUS__Q1","https:\u002F\u002Fwww.jimmunol.org\u002F",{"impactFactor":25,"impactFactorByYear":92,"i10Index":105,"i10IndexLast5Year":106,"totalPublication":107,"totalPublicationByYear":108,"totalCitation":145,"totalCitationByYear":146,"totalCitationPerPublication":210,"totalCitationPerPublicationByYear":211,"hindexLast5Year":208,"hindex":208},{"2012":93,"2013":94,"2014":95,"2015":96,"2016":97,"2017":98,"2018":99,"2019":100,"2020":101,"2021":102,"2022":103,"2023":104},13.39,10.87,12.27,11.23,7.69,7.43,7.78,7.73,8.29,8,10.57,9.43,1346,13,1361,{"1938":109,"1940":110,"1946":109,"1954":110,"1956":109,"1958":110,"1959":110,"1963":110,"1965":111,"1966":112,"1967":110,"1968":112,"1969":112,"1970":111,"1971":112,"1972":113,"1973":112,"1974":111,"1975":114,"1976":115,"1977":116,"1978":115,"1979":106,"1980":117,"1981":114,"1982":115,"1983":118,"1984":106,"1985":119,"1986":120,"1987":118,"1988":121,"1989":117,"1990":122,"1991":123,"1992":124,"1993":125,"1994":126,"1995":127,"1996":128,"1997":129,"1998":130,"1999":131,"2000":132,"2001":133,"2002":134,"2003":135,"2004":135,"2005":136,"2006":137,"2007":138,"2008":139,"2009":128,"2010":140,"2011":141,"2012":128,"2013":142,"2014":121,"2015":119,"2016":120,"2017":102,"2018":143,"2020":102,"2021":144,"2022":110},2,1,3,4,5,11,16,9,19,14,22,15,23,26,18,25,28,30,33,46,39,43,34,72,62,50,41,51,47,52,48,56,31,29,7,6,275941,{"1938":147,"1940":148,"1946":124,"1954":149,"1956":150,"1958":151,"1959":152,"1963":153,"1965":154,"1966":155,"1967":156,"1968":157,"1969":158,"1970":159,"1971":160,"1972":161,"1973":162,"1974":163,"1975":164,"1976":165,"1977":166,"1978":167,"1979":168,"1980":169,"1981":170,"1982":171,"1983":172,"1984":173,"1985":174,"1986":175,"1987":176,"1988":177,"1989":178,"1990":179,"1991":180,"1992":181,"1993":182,"1994":183,"1995":184,"1996":185,"1997":186,"1998":187,"1999":188,"2000":189,"2001":190,"2002":191,"2003":192,"2004":193,"2005":194,"2006":195,"2007":196,"2008":197,"2009":198,"2010":199,"2011":200,"2012":201,"2013":202,"2014":203,"2015":204,"2016":205,"2017":206,"2018":207,"2020":208,"2021":209,"2022":109},132,133,343,176,24,12,37,1696,1086,144,459,484,309,623,1665,369,300,3869,1675,893,5047,2120,4285,2159,2178,3539,5757,4687,4465,3604,7849,3027,6105,4163,7713,5973,5588,4485,9212,6077,7333,10185,17597,15402,10916,8747,11413,9080,11163,9711,7885,8426,12208,5427,6483,5070,2129,1764,1099,582,325,268,239,202.75,{"1938":212,"1940":148,"1946":213,"1954":149,"1956":214,"1958":151,"1959":152,"1963":153,"1965":215,"1966":216,"1967":156,"1968":217,"1969":218,"1970":219,"1971":220,"1972":221,"1973":222,"1974":223,"1975":224,"1976":225,"1977":226,"1978":227,"1979":228,"1980":229,"1981":230,"1982":231,"1983":232,"1984":233,"1985":234,"1986":235,"1987":236,"1988":237,"1989":238,"1990":239,"1991":240,"1992":241,"1993":242,"1994":243,"1995":244,"1996":245,"1997":246,"1998":247,"1999":248,"2000":249,"2001":250,"2002":251,"2003":252,"2004":253,"2005":254,"2006":255,"2007":256,"2008":257,"2009":258,"2010":259,"2011":260,"2012":261,"2013":262,"2014":263,"2015":264,"2016":265,"2017":266,"2018":267,"2020":268,"2021":269,"2022":109},66,12.5,88,565.33,271.5,114.75,121,103,155.75,333,92.25,100,351.73,104.69,99.22,315.44,163.08,225.53,196.27,136.12,252.79,442.85,213.05,297.67,257.43,341.26,159.32,234.81,231.28,308.52,213.32,186.27,135.91,200.26,155.82,170.53,299.56,244.4,248.42,218.32,213.34,278.37,178.04,237.51,186.75,164.27,183.17,218,175.06,140.93,174.83,92.57,80.18,73.27,72.75,46.43,33.5,39.83,{"meta":271,"data":273},{"total":272},"2039",[274,616,918,1173,1524,1709,1859,2324,2921,3242],{"id":275,"createTime":276,"updateTime":277,"relativeEntities":278,"slug":279,"properties":280,"entityType":295,"verifyStatus":296,"verifyTime":276,"verifyNote":297,"languages":298,"translateLanguages":24,"viewCount":25,"primaryUrl":300,"fullTextUrl":24,"authors":301,"publicationType":423,"publisherRelationship":424,"citationCount":479,"citationInfo":480,"publishDate":483,"publishYear":481,"citationAnalyzeStatus":484,"lastCitationAnalyze":485,"indexDatabases":486,"openAccess":24,"references":487,"isForceReanalyzing":615},"47c33c85-08c0-4a4c-8138-324e370e5e5b","2024-10-15T14:50:02.372+00:00","2026-08-15T02:29:25.004+00:00",[],"Emergence-of-CD8-T-Cells-Expressing-NK-Cell-Receptors-in-Influenza-A-Virus-Infected-Mice",{"mag":281,"gsPaper":283,"openalex":285,"abstract":287,"title":289,"pm":291,"doi":293},{"VOID":282},"2100201151",{"VOID":284},"[\"10057444529121065044\"]",{"VOID":286},"W2100201151",{"EN":288},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:p>Both innate and adaptive immune responses play an important role in the recovery of the host from viral infections. In the present report, a subset of cells coexpressing CD8 and NKR-P1C (NK1.1) was found in the lungs of mice infected with influenza A virus. These cells were detected at low numbers in the lungs of uninfected mice, but represented up to 10% of the total CD8+ T cell population at day 10 postinfection. Almost all of the CD8+NK1.1+ cells were CD8αβ+CD3+TCRαβ+ and a proportion of these cells also expressed the NK cell-associated Ly49 receptors. Interestingly, up to 30% of these cells were virus-specific T cells as determined by MHC class I tetramer staining and by intracellular staining of IFN-γ after viral peptide stimulation. Moreover, these cells were distinct from conventional NKT cells as they were also found at increased numbers in influenza-infected CD1−\u002F− mice. These results demonstrate that a significant proportion of CD8+ T cells acquire NK1.1 and other NK cell-associated molecules, and suggests that these receptors may possibly regulate CD8+ T cell effector functions during viral infection.\u003C\u002Fjats:p>",{"EN":290},"Emergence of CD8+ T Cells Expressing NK Cell Receptors in Influenza A Virus-Infected Mice",{"VOID":292},"11046023",{"VOID":294},"10.4049\u002Fjimmunol.165.9.4964","PUBLICATION","VERIFIED","Auto Verify",[299],"EN","https:\u002F\u002Fjournals.aai.org\u002Fjimmunol\u002Farticle\u002F165\u002F9\u002F4964\u002F69849\u002FEmergence-of-CD8-T-Cells-Expressing-NK-Cell",[302,321,338,355,372,389,406],{"id":303,"sortIndex":25,"researcher":24,"roles":304,"affiliations":305,"properties":314,"displayName":318,"givenName":24,"familyName":24},"420fd77f-3815-40a6-ac22-cc787572001f",[],[306],{"id":307,"sortIndex":25,"affiliation":308,"properties":24},"f4dde67b-4401-4820-9109-74362197a51e",{"id":307,"createTime":24,"updateTime":24,"relativeEntities":309,"slug":24,"properties":310,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":313,"statistic":24},[],{"title":311},{"VI":312},"Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden",[],{"orcid":315,"title":317,"openalex":319},{"VOID":316},"https:\u002F\u002Forcid.org\u002F0000-0002-6753-3181",{"EN":318},"Taku Kambayashi",{"VOID":320},"A5037534938",{"id":322,"sortIndex":110,"researcher":24,"roles":323,"affiliations":324,"properties":331,"displayName":335,"givenName":24,"familyName":24},"5d212cd2-052d-4f8f-8af0-1ce87535831f",[],[325],{"id":307,"sortIndex":25,"affiliation":326,"properties":24},{"id":307,"createTime":24,"updateTime":24,"relativeEntities":327,"slug":24,"properties":328,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":330,"statistic":24},[],{"title":329},{"VI":312},[],{"orcid":332,"title":334,"openalex":336},{"VOID":333},"https:\u002F\u002Forcid.org\u002F0000-0001-6183-4904",{"EN":335},"Erika Assarsson",{"VOID":337},"A5038957611",{"id":339,"sortIndex":109,"researcher":24,"roles":340,"affiliations":341,"properties":348,"displayName":352,"givenName":24,"familyName":24},"fdb45c53-34df-4b81-a916-238fd19dbaed",[],[342],{"id":307,"sortIndex":25,"affiliation":343,"properties":24},{"id":307,"createTime":24,"updateTime":24,"relativeEntities":344,"slug":24,"properties":345,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":347,"statistic":24},[],{"title":346},{"VI":312},[],{"orcid":349,"title":351,"openalex":353},{"VOID":350},"https:\u002F\u002Forcid.org\u002F0000-0001-6948-7281",{"EN":352},"Jakob Michaëlsson",{"VOID":354},"A5010988421",{"id":356,"sortIndex":111,"researcher":24,"roles":357,"affiliations":358,"properties":365,"displayName":369,"givenName":24,"familyName":24},"a349875d-a7ad-44de-aed9-87590214b807",[],[359],{"id":307,"sortIndex":25,"affiliation":360,"properties":24},{"id":307,"createTime":24,"updateTime":24,"relativeEntities":361,"slug":24,"properties":362,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":364,"statistic":24},[],{"title":363},{"VI":312},[],{"orcid":366,"title":368,"openalex":370},{"VOID":367},"https:\u002F\u002Forcid.org\u002F0000-0003-2367-1686",{"EN":369},"Peter Berglund",{"VOID":371},"A5020078440",{"id":373,"sortIndex":112,"researcher":24,"roles":374,"affiliations":375,"properties":382,"displayName":386,"givenName":24,"familyName":24},"80a280f7-18dd-402f-893f-42534eca72c3",[],[376],{"id":307,"sortIndex":25,"affiliation":377,"properties":24},{"id":307,"createTime":24,"updateTime":24,"relativeEntities":378,"slug":24,"properties":379,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":381,"statistic":24},[],{"title":380},{"VI":312},[],{"orcid":383,"title":385,"openalex":387},{"VOID":384},"https:\u002F\u002Forcid.org\u002F0000-0001-9990-8331",{"EN":386},"Alexander D. Diehl",{"VOID":388},"A5084833749",{"id":390,"sortIndex":113,"researcher":24,"roles":391,"affiliations":392,"properties":399,"displayName":403,"givenName":24,"familyName":24},"16851f3e-8e94-46cf-9844-2260de3f8f22",[],[393],{"id":307,"sortIndex":25,"affiliation":394,"properties":24},{"id":307,"createTime":24,"updateTime":24,"relativeEntities":395,"slug":24,"properties":396,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":398,"statistic":24},[],{"title":397},{"VI":312},[],{"orcid":400,"title":402,"openalex":404},{"VOID":401},"https:\u002F\u002Forcid.org\u002F0000-0003-0437-8441",{"EN":403},"Benedict J. Chambers",{"VOID":405},"A5071151109",{"id":407,"sortIndex":144,"researcher":24,"roles":408,"affiliations":409,"properties":416,"displayName":420,"givenName":24,"familyName":24},"27ab33f1-bc6b-42e1-a6c6-fbee9c400413",[],[410],{"id":307,"sortIndex":25,"affiliation":411,"properties":24},{"id":307,"createTime":24,"updateTime":24,"relativeEntities":412,"slug":24,"properties":413,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":415,"statistic":24},[],{"title":414},{"VI":312},[],{"orcid":417,"title":419,"openalex":421},{"VOID":418},"https:\u002F\u002Forcid.org\u002F0000-0003-0908-7387",{"EN":420},"Hans‐Gustaf Ljunggren",{"VOID":422},"A5091546357","ARTICLE",{"url":24,"publisher":425,"properties":472},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":426,"slug":10,"properties":427,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":432,"manageAffiliations":441,"indexDatabases":452,"url":90,"thumbnailPath":24,"statistic":467,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":428,"eissn":429,"issn":430,"title":431},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[433,437],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":434,"label":435,"description":436,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":438,"label":439,"description":440,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[442,447],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":443,"slug":24,"properties":444,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":446,"statistic":24},[],{"title":445},{"EN":45},[],{"id":48,"createTime":24,"updateTime":24,"relativeEntities":448,"slug":24,"properties":449,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":451,"statistic":24},[],{"title":450},{"EN":52},[],[453,460],{"id":56,"indexDatabase":454,"url":69,"indexYears":24,"academicFieldIds":459,"indexDatabaseRanking":24},{"id":58,"createTime":24,"updateTime":24,"relativeEntities":455,"label":456,"description":457,"key":65,"publicationTags":458,"standard":24},[],{"EN":61,"VI":61},{"EN":63,"VI":64},[67,68],[71],{"id":73,"indexDatabase":461,"url":84,"indexYears":85,"academicFieldIds":466,"indexDatabaseRanking":89},{"id":75,"createTime":24,"updateTime":24,"relativeEntities":462,"label":463,"description":464,"key":81,"publicationTags":465,"standard":24},[],{"EN":78,"VI":78},{"EN":78,"VI":80},[83],[87,88],{"impactFactor":25,"impactFactorByYear":468,"i10Index":105,"i10IndexLast5Year":106,"totalPublication":107,"totalPublicationByYear":469,"totalCitation":145,"totalCitationByYear":470,"totalCitationPerPublication":210,"totalCitationPerPublicationByYear":471,"hindexLast5Year":208,"hindex":208},{"2012":93,"2013":94,"2014":95,"2015":96,"2016":97,"2017":98,"2018":99,"2019":100,"2020":101,"2021":102,"2022":103,"2023":104},{"1938":109,"1940":110,"1946":109,"1954":110,"1956":109,"1958":110,"1959":110,"1963":110,"1965":111,"1966":112,"1967":110,"1968":112,"1969":112,"1970":111,"1971":112,"1972":113,"1973":112,"1974":111,"1975":114,"1976":115,"1977":116,"1978":115,"1979":106,"1980":117,"1981":114,"1982":115,"1983":118,"1984":106,"1985":119,"1986":120,"1987":118,"1988":121,"1989":117,"1990":122,"1991":123,"1992":124,"1993":125,"1994":126,"1995":127,"1996":128,"1997":129,"1998":130,"1999":131,"2000":132,"2001":133,"2002":134,"2003":135,"2004":135,"2005":136,"2006":137,"2007":138,"2008":139,"2009":128,"2010":140,"2011":141,"2012":128,"2013":142,"2014":121,"2015":119,"2016":120,"2017":102,"2018":143,"2020":102,"2021":144,"2022":110},{"1938":147,"1940":148,"1946":124,"1954":149,"1956":150,"1958":151,"1959":152,"1963":153,"1965":154,"1966":155,"1967":156,"1968":157,"1969":158,"1970":159,"1971":160,"1972":161,"1973":162,"1974":163,"1975":164,"1976":165,"1977":166,"1978":167,"1979":168,"1980":169,"1981":170,"1982":171,"1983":172,"1984":173,"1985":174,"1986":175,"1987":176,"1988":177,"1989":178,"1990":179,"1991":180,"1992":181,"1993":182,"1994":183,"1995":184,"1996":185,"1997":186,"1998":187,"1999":188,"2000":189,"2001":190,"2002":191,"2003":192,"2004":193,"2005":194,"2006":195,"2007":196,"2008":197,"2009":198,"2010":199,"2011":200,"2012":201,"2013":202,"2014":203,"2015":204,"2016":205,"2017":206,"2018":207,"2020":208,"2021":209,"2022":109},{"1938":212,"1940":148,"1946":213,"1954":149,"1956":214,"1958":151,"1959":152,"1963":153,"1965":215,"1966":216,"1967":156,"1968":217,"1969":218,"1970":219,"1971":220,"1972":221,"1973":222,"1974":223,"1975":224,"1976":225,"1977":226,"1978":227,"1979":228,"1980":229,"1981":230,"1982":231,"1983":232,"1984":233,"1985":234,"1986":235,"1987":236,"1988":237,"1989":238,"1990":239,"1991":240,"1992":241,"1993":242,"1994":243,"1995":244,"1996":245,"1997":246,"1998":247,"1999":248,"2000":249,"2001":250,"2002":251,"2003":252,"2004":253,"2005":254,"2006":255,"2007":256,"2008":257,"2009":258,"2010":259,"2011":260,"2012":261,"2013":262,"2014":263,"2015":264,"2016":265,"2017":266,"2018":267,"2020":268,"2021":269,"2022":109},{"issue":473,"pages":475,"volume":477},{"VOID":474},"9",{"VOID":476},"4964-4969",{"VOID":478},"165",139,{"total":479,"publishYear":481,"statisticByYear":482},2000,{"1985":110,"2000":110,"2001":123,"2002":119,"2003":118,"2004":120,"2005":114,"2006":116,"2007":110,"2008":102,"2009":112,"2010":111,"2011":109,"2012":110,"2013":111,"2014":113,"2015":112,"2016":109,"2017":110,"2018":112,"2021":112,"2022":110,"2023":109,"2024":110,"2025":110},"2000-11-01","ERROR_IN_ANALYZE_CITATION","2026-08-15T02:29:25.003+00:00",[67,89],[488,492,496,499,503,507,511,515,519,523,527,531,535,539,543,547,551,555,559,563,567,571,575,579,583,587,591,595,599,603,607,611],{"id":24,"text":489,"url":24,"identifiers":490},"Eichelberger, M.,  W. Allan,  M. Zijlstra,  R. Jaenisch,  P. C. Doherty.  1991. Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells. J. Exp. Med. 174: 875",{"doi":491},"10.1084\u002Fjem.174.4.875",{"id":24,"text":493,"url":24,"identifiers":494},"Biron, C. A..  1997. Activation and function of natural killer cell responses during viral infections. Curr. Opin. Immunol. 9: 24",{"doi":495},"10.1016\u002FS0952-7915(97)80155-0",{"id":24,"text":497,"url":24,"identifiers":498},"Welsh, R. M..  1984. Natural killer cells and interferon. Crit. Rev. Immunol. 5: 55",{},{"id":24,"text":500,"url":24,"identifiers":501},"Trinchieri, G..  1989. Biology of natural killer cells. Adv. Immunol. 47: 187",{"doi":502},"10.1016\u002FS0065-2776(08)60664-1",{"id":24,"text":504,"url":24,"identifiers":505},"Arora, D. J.,  M. Houde,  D. M. Justewicz,  R. Mandeville.  1984. In vitro enhancement of human natural cell-mediated cytotoxicity by purified influenza virus glycoproteins. J. Virol. 52: 839",{"doi":506},"10.1128\u002Fjvi.52.3.839-845.1984",{"id":24,"text":508,"url":24,"identifiers":509},"Lanier, L. L..  1998. NK cell receptors. Annu. Rev. Immunol. 16: 359",{"doi":510},"10.1146\u002Fannurev.immunol.16.1.359",{"id":24,"text":512,"url":24,"identifiers":513},"Ljunggren, H. G.,  K. Kärre.  1990. In search of the ’missing self’: MHC molecules and NK cell recognition. Immunol. Today 11: 237",{"doi":514},"10.1016\u002F0167-5699(90)90097-S",{"id":24,"text":516,"url":24,"identifiers":517},"Vicari, A. P.,  A. Zlotnik.  1996. Mouse NK1.1+ T cells: a new family of T cells. Immunol. Today 17: 71",{"doi":518},"10.1016\u002F0167-5699(96)80582-2",{"id":24,"text":520,"url":24,"identifiers":521},"Bendelac, A.,  M. N. Rivera,  S. H. Park,  J. H. Roark.  1997. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu. Rev. Immunol. 15: 535",{"doi":522},"10.1146\u002Fannurev.immunol.15.1.535",{"id":24,"text":524,"url":24,"identifiers":525},"Mendiratta, S. K.,  W. D. Martin,  S. Hong,  A. Boesteanu,  S. Joyce,  L. Van Kaer.  1997. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6: 469",{"doi":526},"10.1016\u002FS1074-7613(00)80290-3",{"id":24,"text":528,"url":24,"identifiers":529},"Haanen, J. B.,  M. Toebes,  T. A. Cordaro,  M. C. Wolkers,  A. M. Kruisbeek,  T. N. Schumacher.  1999. Systemic T cell expansion during localized viral infection. Eur. J. Immunol. 29: 1168",{"doi":530},"10.1002\u002F(SICI)1521-4141(199904)29:04\u003C1168::AID-IMMU1168>3.0.CO;2-J",{"id":24,"text":532,"url":24,"identifiers":533},"Achour, A.,  R. A. Harris,  K. Persson,  J. Sundback,  C. L. Sentman,  G. Schneider,  Y. Lindqvist,  K. Kärre.  1999. Murine class I major histocompatibility complex H-2Dd: expression, refolding and crystallization. Acta Crystallogr. D 55: 260",{"doi":534},"10.1107\u002FS0907444998005265",{"id":24,"text":536,"url":24,"identifiers":537},"Garboczi, D. N.,  D. T. Hung,  D. C. Wiley.  1992. HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides. Proc. Natl. Acad. Sci. USA 89: 3429",{"doi":538},"10.1073\u002Fpnas.89.8.3429",{"id":24,"text":540,"url":24,"identifiers":541},"Biron, C. A.,  K. B. Nguyen,  G. C. Pien,  L. P. Cousens,  T. P. Salazar-Mather.  1999. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 17: 189",{"doi":542},"10.1146\u002Fannurev.immunol.17.1.189",{"id":24,"text":544,"url":24,"identifiers":545},"Altman, J. D.,  P. A. H. Moss,  P. J. R. Goulder,  D. H. Barouch,  M. G. McHeyzer-Williams,  J. I. Bell,  A. J. McMichael,  M. M. Davis.  1996. Phenotypic analysis of antigen-specific T lymphocytes. Science 274: 94",{"doi":546},"10.1126\u002Fscience.274.5284.94",{"id":24,"text":548,"url":24,"identifiers":549},"Flynn, K. J.,  G. T. Belz,  J. D. Altman,  R. Ahmed,  D. L. Woodland,  P. C. Doherty.  1998. Virus-specific CD8+ T cells in primary and secondary influenza pneumonia. Immunity 8: 683",{"doi":550},"10.1016\u002FS1074-7613(00)80573-7",{"id":24,"text":552,"url":24,"identifiers":553},"Koo, G. C.,  F. J. Dumont,  M. Tutt,  J. Hackett, Jr,  V. Kumar.  1986. The NK-1.1(−) mouse: a model to study differentiation of murine NK cells. J. Immunol. 137: 3742",{"doi":554},"10.4049\u002Fjimmunol.137.12.3742",{"id":24,"text":556,"url":24,"identifiers":557},"Assarsson, E., T. Kambayashi, J. K. Sandberg, S. Hong, M. Taniguchi, L. van Kaer, H. G. Ljunggren, and B. J. Chambers. 2000. CD8+ T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo. J. Immunol. In press.",{"doi":558},"10.4049\u002Fjimmunol.165.7.3673",{"id":24,"text":560,"url":24,"identifiers":561},"Asea, A.,  J. Stein-Streilein.  1998. Signalling through NK1.1 triggers NK cells to die but induces NK T cells to produce interleukin-4. Immunology 93: 296",{"doi":562},"10.1046\u002Fj.1365-2567.1998.00422.x",{"id":24,"text":564,"url":24,"identifiers":565},"Ballas, Z. K.,  W. Rasmussen.  1993. Lymphokine-activated killer cells. VII. IL-4 induces an NK1.1+CD8 α+β− TCR-αβ B220+ lymphokine-activated killer subset. J. Immunol. 150: 17",{"doi":566},"10.4049\u002Fjimmunol.150.1.17",{"id":24,"text":568,"url":24,"identifiers":569},"Ikarashi, Y.,  H. Maruoka,  K. Shinohara,  T. Sugimura,  M. Terada,  H. Wakasugi.  1998. Mouse NK1.1+ cytotoxic T cells can be generated by IL-2 exposure from lymphocytes which express an intermediate level of T cell receptor. Immunol. Lett. 61: 165",{"doi":570},"10.1016\u002FS0165-2478(98)00014-5",{"id":24,"text":572,"url":24,"identifiers":573},"Slifka, M. K.,  R. R. Pagarigan,  J. L. Whitton.  2000. NK markers are expressed on a high percentage of virus-specific CD8+ and CD4+ T cells. J. Immunol. 164: 2009",{"doi":574},"10.4049\u002Fjimmunol.164.4.2009",{"id":24,"text":576,"url":24,"identifiers":577},"Coles, M. C.,  C. W. McMahon,  H. Takizawa,  D. H. Raulet.  2000. Memory CD8 T lymphocytes express inhibitory MHC-specific Ly49 receptors. Eur. J. Immunol. 30: 236",{"doi":578},"10.1002\u002F1521-4141(200001)30:1\u003C236::AID-IMMU236>3.0.CO;2-X",{"id":24,"text":580,"url":24,"identifiers":581},"Ishihara, S.,  M. Nieda,  J. Kitayama,  T. Osada,  T. Yabe,  Y. Ishikawa,  H. Nagawa,  T. Muto,  T. Juji.  1999. CD8+NKR-P1A+T cells preferentially accumulate in human liver. Eur. J. Immunol. 29: 2406",{"doi":582},"10.1002\u002F(SICI)1521-4141(199908)29:08\u003C2406::AID-IMMU2406>3.0.CO;2-F",{"id":24,"text":584,"url":24,"identifiers":585},"Mingari, M. C.,  C. Vitale,  A. Cambiaggi,  F. Schiavetti,  G. Melioli,  S. Ferrini,  A. Poggi.  1995. Cytolytic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production. Int. Immunol. 7: 697",{"doi":586},"10.1093\u002Fintimm\u002F7.4.697",{"id":24,"text":588,"url":24,"identifiers":589},"Mingari, M. C.,  F. Schiavetti,  M. Ponte,  C. Vitale,  E. Maggi,  S. Romagnani,  J. Demarest,  G. Pantaleo,  A. S. Fauci,  L. Moretta.  1996. Human CD8+ T lymphocyte subsets that express HLA class I-specific inhibitory receptors represent oligoclonally or monoclonally expanded cell populations. Proc. Natl. Acad. Sci. USA 93: 12433",{"doi":590},"10.1073\u002Fpnas.93.22.12433",{"id":24,"text":592,"url":24,"identifiers":593},"Phillips, J. H.,  J. E. Gumperz,  P. Parham,  L. L. Lanier.  1995. Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes. Science 268: 403",{"doi":594},"10.1126\u002Fscience.7716542",{"id":24,"text":596,"url":24,"identifiers":597},"D’Andrea, A.,  C. Chang,  J. H. Phillips,  L. L. Lanier.  1996. Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. J. Exp. Med. 184: 789",{"doi":598},"10.1084\u002Fjem.184.2.789",{"id":24,"text":600,"url":24,"identifiers":601},"Mingari, M. C.,  M. Ponte,  S. Bertone,  F. Schiavetti,  C. Vitale,  R. Bellomo,  A. Moretta,  L. Moretta.  1998. HLA class I-specific inhibitory receptors in human T lymphocytes: interleukin 15-induced expression of CD94\u002FNKG2A in superantigen- or alloantigen-activated CD8+ T cells. Proc. Natl. Acad. Sci. USA 95: 1172",{"doi":602},"10.1073\u002Fpnas.95.3.1172",{"id":24,"text":604,"url":24,"identifiers":605},"Speiser, D. E.,  M. J. Pittet,  D. Valmori,  R. Dunbar,  D. Rimoldi,  D. Lienard,  H. R. MacDonald,  J. C. Cerottini,  V. Cerundolo,  P. Romero.  1999. In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes. J. Exp. Med. 190: 775",{"doi":606},"10.1084\u002Fjem.190.6.775",{"id":24,"text":608,"url":24,"identifiers":609},"De Maria, A.,  A. Ferraris,  M. Guastella,  S. Pilia,  C. Cantoni,  L. Polero,  M. C. Mingari,  D. Bassetti,  A. S. Fauci,  L. Moretta.  1997. Expression of HLA class I-specific inhibitory natural killer cell receptors in HIV-specific cytolytic T lymphocytes: impairment of specific cytolytic functions. Proc. Natl. Acad. Sci. USA 94: 10285",{"doi":610},"10.1073\u002Fpnas.94.19.10285",{"id":24,"text":612,"url":24,"identifiers":613},"Zajac, A. J.,  R. E. Vance,  W. Held,  D. J. Sourdive,  J. D. Altman,  D. H. Raulet,  R. Ahmed.  1999. Impaired anti-viral T cell responses due to expression of the Ly49A inhibitory receptor. J. Immunol. 163: 5526",{"doi":614},"10.4049\u002Fjimmunol.163.10.5526",false,{"id":617,"createTime":618,"updateTime":619,"relativeEntities":620,"slug":621,"properties":622,"entityType":295,"verifyStatus":296,"verifyTime":618,"verifyNote":297,"languages":637,"translateLanguages":24,"viewCount":25,"primaryUrl":638,"fullTextUrl":24,"authors":639,"publicationType":423,"publisherRelationship":856,"citationCount":25,"citationInfo":911,"publishDate":914,"publishYear":912,"citationAnalyzeStatus":915,"lastCitationAnalyze":619,"indexDatabases":916,"openAccess":24,"references":917,"isForceReanalyzing":615},"7a6e8d75-663a-4fe1-8053-274c2a158592","2024-10-15T23:08:03.077+00:00","2026-07-30T00:19:39.718+00:00",[],"Cytokine-control-of-parasite-specific-anergy-in-human-urinary-schistosomiasis-IL-10-modulates-lymphocyte-reactivity-",{"mag":623,"gsPaper":625,"openalex":627,"abstract":629,"title":631,"pm":633,"doi":635},{"VOID":624},"2106459612",{"VOID":626},"[\"7782851993250575498\"]",{"VOID":628},"W2106459612",{"EN":630},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:p>Humans chronically infected with schistosomiasis usually have impaired parasite Ag-specific lymphocyte proliferation and IFN-gamma production that may facilitate persistence of the parasite while producing little clinical disease. The mechanisms that contribute to the immunologic hyporesponsiveness in these patients remain undefined. IL-10 has been shown to exert an inhibitory effect on cell-mediated immunity. To determine whether endogenous IL-10 has a role in regulating parasite-specific anergy in schistosomiasis, neutralizing anti-IL-10 added to PBMC from Schistosoma haematobium patients' enhanced adult worm (SWAP)- or egg Ag (SEA)-driven lymphocyte proliferation and\u002For IFN-gamma production by 2- to >100-fold in 32 of 38 subjects. In contrast, anti-IL-10 failed to significantly augment the mycobacterial Ag, purified protein derivative (PPD)-driven lymphocyte proliferation, or IFN-gamma production in 9 or 10 of 14 individuals, respectively. SWAP or SEA triggered IL-10 release from PBMC of both patients and healthy individuals; however, CD4+ cells were a significant source of IL-10 only in infected subjects. PPD relative to SWAP induced fivefold less IL-10 release by CD4+ cells (p < 0.01). A possible mechanism whereby IL-10 suppressed Ag-specific T cell responses was demonstrated by the ability of SWAP and not PPD to suppress B7 expression on PBMC. Anti-IL-10 completely inhibited the parasite Ag-induced down-regulation of B7 expression. These studies indicate that IL-10 contributes to parasite Ag-induced T cell hyporesponsiveness observed in patients with chronic schistosomiasis hematobia.\u003C\u002Fjats:p>",{"EN":632},"Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivity.",{"VOID":634},"8648117",{"VOID":636},"10.4049\u002Fjimmunol.156.12.4715",[299],"https:\u002F\u002Fjournals.aai.org\u002Fjimmunol\u002Farticle\u002F156\u002F12\u002F4715\u002F28737\u002FCytokine-control-of-parasite-specific-anergy-in",[640,659,678,695,710,727,742,757,774,791,806,822,839],{"id":641,"sortIndex":25,"researcher":24,"roles":642,"affiliations":643,"properties":652,"displayName":656,"givenName":24,"familyName":24},"60d462ec-27ef-4507-9f22-83a2cc2522b6",[],[644],{"id":645,"sortIndex":25,"affiliation":646,"properties":24},"4c3cce2f-4568-4657-a825-4cab0b6c82f4",{"id":645,"createTime":24,"updateTime":24,"relativeEntities":647,"slug":24,"properties":648,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":651,"statistic":24},[],{"title":649},{"EN":650},"Division of Geographic Medicine, Western Reserve University, Cleveland, OH 44106, USA.",[],{"orcid":653,"title":655,"openalex":657},{"VOID":654},"https:\u002F\u002Forcid.org\u002F0000-0003-3873-7860",{"EN":656},"Christopher L. King",{"VOID":658},"A5032632789",{"id":660,"sortIndex":110,"researcher":24,"roles":661,"affiliations":662,"properties":669,"displayName":673,"givenName":24,"familyName":24},"539b7cb8-79c4-4c10-a352-759c81423b67",[],[663],{"id":645,"sortIndex":25,"affiliation":664,"properties":24},{"id":645,"createTime":24,"updateTime":24,"relativeEntities":665,"slug":24,"properties":666,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":668,"statistic":24},[],{"title":667},{"EN":650},[],{"orcid":670,"title":672,"gsAuthor":674,"openalex":676},{"VOID":671},"https:\u002F\u002Forcid.org\u002F0000-0001-5174-9001",{"EN":673},"Ahmed Medhat",{"VOID":675},"[\"46JZ05YAAAAJ\"]",{"VOID":677},"A5032396346",{"id":679,"sortIndex":109,"researcher":24,"roles":680,"affiliations":681,"properties":688,"displayName":692,"givenName":24,"familyName":24},"61d94eee-debf-4564-a7b8-944ac7982eb1",[],[682],{"id":645,"sortIndex":25,"affiliation":683,"properties":24},{"id":645,"createTime":24,"updateTime":24,"relativeEntities":684,"slug":24,"properties":685,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":687,"statistic":24},[],{"title":686},{"EN":650},[],{"orcid":689,"title":691,"openalex":693},{"VOID":690},"https:\u002F\u002Forcid.org\u002F0000-0003-0144-1089",{"EN":692},"Indu Malhotra",{"VOID":694},"A5079039984",{"id":696,"sortIndex":111,"researcher":24,"roles":697,"affiliations":698,"properties":705,"displayName":707,"givenName":24,"familyName":24},"aa2cf2f1-fba1-40d6-be06-d9d5fb28d1df",[],[699],{"id":645,"sortIndex":25,"affiliation":700,"properties":24},{"id":645,"createTime":24,"updateTime":24,"relativeEntities":701,"slug":24,"properties":702,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":704,"statistic":24},[],{"title":703},{"EN":650},[],{"title":706,"openalex":708},{"EN":707},"M A Nafeh",{"VOID":709},"A5074386565",{"id":711,"sortIndex":112,"researcher":24,"roles":712,"affiliations":713,"properties":720,"displayName":724,"givenName":24,"familyName":24},"da7b8cb0-bec2-4bd2-ae0d-cde7c819d6a6",[],[714],{"id":645,"sortIndex":25,"affiliation":715,"properties":24},{"id":645,"createTime":24,"updateTime":24,"relativeEntities":716,"slug":24,"properties":717,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":719,"statistic":24},[],{"title":718},{"EN":650},[],{"orcid":721,"title":723,"openalex":725},{"VOID":722},"https:\u002F\u002Forcid.org\u002F0000-0003-4945-7389",{"EN":724},"Ahmed Helmy",{"VOID":726},"A5002577858",{"id":728,"sortIndex":113,"researcher":24,"roles":729,"affiliations":730,"properties":737,"displayName":739,"givenName":24,"familyName":24},"78581e98-de3f-4287-b994-073db2b7966b",[],[731],{"id":645,"sortIndex":25,"affiliation":732,"properties":24},{"id":645,"createTime":24,"updateTime":24,"relativeEntities":733,"slug":24,"properties":734,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":736,"statistic":24},[],{"title":735},{"EN":650},[],{"title":738,"openalex":740},{"EN":739},"Joseph Khaudary",{"VOID":741},"A5058887911",{"id":743,"sortIndex":144,"researcher":24,"roles":744,"affiliations":745,"properties":752,"displayName":754,"givenName":24,"familyName":24},"004f4670-63bc-48f6-bf60-a7dce054644e",[],[746],{"id":645,"sortIndex":25,"affiliation":747,"properties":24},{"id":645,"createTime":24,"updateTime":24,"relativeEntities":748,"slug":24,"properties":749,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":751,"statistic":24},[],{"title":750},{"EN":650},[],{"title":753,"openalex":755},{"EN":754},"Shakir Z. Ibrahim",{"VOID":756},"A5078170540",{"id":758,"sortIndex":143,"researcher":24,"roles":759,"affiliations":760,"properties":767,"displayName":771,"givenName":24,"familyName":24},"c3a93c1c-c451-4fc8-9953-77269191fed8",[],[761],{"id":645,"sortIndex":25,"affiliation":762,"properties":24},{"id":645,"createTime":24,"updateTime":24,"relativeEntities":763,"slug":24,"properties":764,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":766,"statistic":24},[],{"title":765},{"EN":650},[],{"orcid":768,"title":770,"openalex":772},{"VOID":769},"https:\u002F\u002Forcid.org\u002F0000-0001-5088-2783",{"EN":771},"M. El-Sherbiny",{"VOID":773},"A5002684475",{"id":775,"sortIndex":102,"researcher":24,"roles":776,"affiliations":777,"properties":784,"displayName":788,"givenName":24,"familyName":24},"b5cb21b2-a376-4814-8e7a-562d7587aaff",[],[778],{"id":645,"sortIndex":25,"affiliation":779,"properties":24},{"id":645,"createTime":24,"updateTime":24,"relativeEntities":780,"slug":24,"properties":781,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":783,"statistic":24},[],{"title":782},{"EN":650},[],{"orcid":785,"title":787,"openalex":789},{"VOID":786},"https:\u002F\u002Forcid.org\u002F0000-0003-4123-9221",{"EN":788},"Samy Zaky",{"VOID":790},"A5067279761",{"id":792,"sortIndex":116,"researcher":24,"roles":793,"affiliations":794,"properties":801,"displayName":803,"givenName":24,"familyName":24},"8be6bac0-288a-4352-81b7-c0187a460107",[],[795],{"id":645,"sortIndex":25,"affiliation":796,"properties":24},{"id":645,"createTime":24,"updateTime":24,"relativeEntities":797,"slug":24,"properties":798,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":800,"statistic":24},[],{"title":799},{"EN":650},[],{"title":802,"openalex":804},{"EN":803},"Robert J. Stupi",{"VOID":805},"A5014124653",{"id":807,"sortIndex":808,"researcher":24,"roles":809,"affiliations":810,"properties":817,"displayName":819,"givenName":24,"familyName":24},"0823167a-ad38-41db-bf75-f1c1ca8af98b",10,[],[811],{"id":645,"sortIndex":25,"affiliation":812,"properties":24},{"id":645,"createTime":24,"updateTime":24,"relativeEntities":813,"slug":24,"properties":814,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":816,"statistic":24},[],{"title":815},{"EN":650},[],{"title":818,"openalex":820},{"EN":819},"Kim Brustoski",{"VOID":821},"A5008284332",{"id":823,"sortIndex":114,"researcher":24,"roles":824,"affiliations":825,"properties":832,"displayName":836,"givenName":24,"familyName":24},"255034a9-8cf9-401b-a384-9481fe568ed8",[],[826],{"id":645,"sortIndex":25,"affiliation":827,"properties":24},{"id":645,"createTime":24,"updateTime":24,"relativeEntities":828,"slug":24,"properties":829,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":831,"statistic":24},[],{"title":830},{"EN":650},[],{"orcid":833,"title":835,"openalex":837},{"VOID":834},"https:\u002F\u002Forcid.org\u002F0000-0002-9498-4594",{"EN":836},"Mohamed Shehata",{"VOID":838},"A5101816084",{"id":840,"sortIndex":152,"researcher":24,"roles":841,"affiliations":842,"properties":849,"displayName":853,"givenName":24,"familyName":24},"8e69f549-6260-43bf-837d-867c73de9d12",[],[843],{"id":645,"sortIndex":25,"affiliation":844,"properties":24},{"id":645,"createTime":24,"updateTime":24,"relativeEntities":845,"slug":24,"properties":846,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":848,"statistic":24},[],{"title":847},{"EN":650},[],{"orcid":850,"title":852,"openalex":854},{"VOID":851},"https:\u002F\u002Forcid.org\u002F0000-0003-1907-0570",{"EN":853},"Mohamed Tarek M. Shata",{"VOID":855},"A5038948232",{"url":24,"publisher":857,"properties":904},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":858,"slug":10,"properties":859,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":864,"manageAffiliations":873,"indexDatabases":884,"url":90,"thumbnailPath":24,"statistic":899,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":860,"eissn":861,"issn":862,"title":863},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[865,869],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":866,"label":867,"description":868,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":870,"label":871,"description":872,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[874,879],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":875,"slug":24,"properties":876,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":878,"statistic":24},[],{"title":877},{"EN":45},[],{"id":48,"createTime":24,"updateTime":24,"relativeEntities":880,"slug":24,"properties":881,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":883,"statistic":24},[],{"title":882},{"EN":52},[],[885,892],{"id":56,"indexDatabase":886,"url":69,"indexYears":24,"academicFieldIds":891,"indexDatabaseRanking":24},{"id":58,"createTime":24,"updateTime":24,"relativeEntities":887,"label":888,"description":889,"key":65,"publicationTags":890,"standard":24},[],{"EN":61,"VI":61},{"EN":63,"VI":64},[67,68],[71],{"id":73,"indexDatabase":893,"url":84,"indexYears":85,"academicFieldIds":898,"indexDatabaseRanking":89},{"id":75,"createTime":24,"updateTime":24,"relativeEntities":894,"label":895,"description":896,"key":81,"publicationTags":897,"standard":24},[],{"EN":78,"VI":78},{"EN":78,"VI":80},[83],[87,88],{"impactFactor":25,"impactFactorByYear":900,"i10Index":105,"i10IndexLast5Year":106,"totalPublication":107,"totalPublicationByYear":901,"totalCitation":145,"totalCitationByYear":902,"totalCitationPerPublication":210,"totalCitationPerPublicationByYear":903,"hindexLast5Year":208,"hindex":208},{"2012":93,"2013":94,"2014":95,"2015":96,"2016":97,"2017":98,"2018":99,"2019":100,"2020":101,"2021":102,"2022":103,"2023":104},{"1938":109,"1940":110,"1946":109,"1954":110,"1956":109,"1958":110,"1959":110,"1963":110,"1965":111,"1966":112,"1967":110,"1968":112,"1969":112,"1970":111,"1971":112,"1972":113,"1973":112,"1974":111,"1975":114,"1976":115,"1977":116,"1978":115,"1979":106,"1980":117,"1981":114,"1982":115,"1983":118,"1984":106,"1985":119,"1986":120,"1987":118,"1988":121,"1989":117,"1990":122,"1991":123,"1992":124,"1993":125,"1994":126,"1995":127,"1996":128,"1997":129,"1998":130,"1999":131,"2000":132,"2001":133,"2002":134,"2003":135,"2004":135,"2005":136,"2006":137,"2007":138,"2008":139,"2009":128,"2010":140,"2011":141,"2012":128,"2013":142,"2014":121,"2015":119,"2016":120,"2017":102,"2018":143,"2020":102,"2021":144,"2022":110},{"1938":147,"1940":148,"1946":124,"1954":149,"1956":150,"1958":151,"1959":152,"1963":153,"1965":154,"1966":155,"1967":156,"1968":157,"1969":158,"1970":159,"1971":160,"1972":161,"1973":162,"1974":163,"1975":164,"1976":165,"1977":166,"1978":167,"1979":168,"1980":169,"1981":170,"1982":171,"1983":172,"1984":173,"1985":174,"1986":175,"1987":176,"1988":177,"1989":178,"1990":179,"1991":180,"1992":181,"1993":182,"1994":183,"1995":184,"1996":185,"1997":186,"1998":187,"1999":188,"2000":189,"2001":190,"2002":191,"2003":192,"2004":193,"2005":194,"2006":195,"2007":196,"2008":197,"2009":198,"2010":199,"2011":200,"2012":201,"2013":202,"2014":203,"2015":204,"2016":205,"2017":206,"2018":207,"2020":208,"2021":209,"2022":109},{"1938":212,"1940":148,"1946":213,"1954":149,"1956":214,"1958":151,"1959":152,"1963":153,"1965":215,"1966":216,"1967":156,"1968":217,"1969":218,"1970":219,"1971":220,"1972":221,"1973":222,"1974":223,"1975":224,"1976":225,"1977":226,"1978":227,"1979":228,"1980":229,"1981":230,"1982":231,"1983":232,"1984":233,"1985":234,"1986":235,"1987":236,"1988":237,"1989":238,"1990":239,"1991":240,"1992":241,"1993":242,"1994":243,"1995":244,"1996":245,"1997":246,"1998":247,"1999":248,"2000":249,"2001":250,"2002":251,"2003":252,"2004":253,"2005":254,"2006":255,"2007":256,"2008":257,"2009":258,"2010":259,"2011":260,"2012":261,"2013":262,"2014":263,"2015":264,"2016":265,"2017":266,"2018":267,"2020":268,"2021":269,"2022":109},{"issue":905,"pages":907,"volume":909},{"VOID":906},"12",{"VOID":908},"4715-4721",{"VOID":910},"156",{"total":25,"publishYear":912,"statisticByYear":913},1996,{},"1996-06-15","DONE_ANALYZE_CITATION",[67,89],[],{"id":919,"createTime":920,"updateTime":921,"relativeEntities":922,"slug":923,"properties":924,"entityType":295,"verifyStatus":296,"verifyTime":920,"verifyNote":297,"languages":935,"translateLanguages":24,"viewCount":25,"primaryUrl":936,"fullTextUrl":24,"authors":937,"publicationType":423,"publisherRelationship":976,"citationCount":25,"citationInfo":1031,"publishDate":1034,"publishYear":1032,"citationAnalyzeStatus":915,"lastCitationAnalyze":921,"indexDatabases":1035,"openAccess":24,"references":1036,"isForceReanalyzing":615},"4e465494-ec2e-4e5e-80bf-136611f226f4","2024-09-23T00:34:47.061+00:00","2026-07-24T19:30:04.687+00:00",[],"Posttranslational-Regulation-of-TCR-V%CE%B1-Allelic-Exclusion-During-T-Cell-Differentiation",{"openalex":925,"abstract":927,"title":929,"gsPaper":931,"doi":933},{"VOID":926},"W4313342477",{"EN":928},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:p>We have previously shown that phenotypic allelic exclusion of TCR α-chain is functional only in mature thymocytes. A significant proportion of immature thymocytes (TCRlow) express more than one cell surface α-chain, but mature thymocytes (TCRhigh) show phenotypic allelic exclusion and express only a single α-chain. We have analyzed thymocytes for both surface and intracellular α-chain expression and find that the majority of mature thymocytes express a second α-chain intracellularly. This result is predicted by a model in which the developmentally regulated allelic exclusion of the TCR α-chain is caused by competition between α-chains for the β-chain rather than by models in which one α-chain is down-regulated or in which selection favors cells with only a single α-chain species. Changes in the relative amounts of α- and β-chains available for pairing may therefore allow competition between the two α-chains for the β-chain. Peripheral T cells also frequently express second α-chains in the cytoplasm (18–27%), despite a rather low frequency of dual α-chain expression on the cell surface (2–4%). The frequency of nonsurface expressed α-chains is reduced somewhat compared with thymocytes, indicating that an additional level of control of allelic exclusion operates during the maturation of peripheral T cells.\u003C\u002Fjats:p>",{"EN":930},"Posttranslational Regulation of TCR Vα Allelic Exclusion During T Cell Differentiation",{"VOID":932},"[\"17806995789171668124\"]",{"VOID":934},"10.4049\u002Fjimmunol.160.8.3883",[299],"https:\u002F\u002Fjournals.aai.org\u002Fjimmunol\u002Farticle\u002F160\u002F8\u002F3883\u002F43914\u002FPosttranslational-Regulation-of-TCR-V-Allelic",[938,957],{"id":939,"sortIndex":25,"researcher":24,"roles":940,"affiliations":941,"properties":950,"displayName":954,"givenName":24,"familyName":24},"1be2c19c-2c21-4c67-acd3-015d32b2b9fa",[],[942],{"id":943,"sortIndex":25,"affiliation":944,"properties":24},"e9dc057f-a11d-4341-b6cd-1594b8f9150c",{"id":943,"createTime":24,"updateTime":24,"relativeEntities":945,"slug":24,"properties":946,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":949,"statistic":24},[],{"title":947},{"EN":948},"*Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037;",[],{"orcid":951,"title":953,"openalex":955},{"VOID":952},"https:\u002F\u002Forcid.org\u002F0000-0003-0941-0703",{"EN":954},"S. Munir Alam",{"VOID":956},"A5027270152",{"id":958,"sortIndex":110,"researcher":24,"roles":959,"affiliations":960,"properties":967,"displayName":971,"givenName":24,"familyName":24},"e9937954-8562-4cdd-bf39-15a0a57e11d7",[],[961],{"id":943,"sortIndex":25,"affiliation":962,"properties":24},{"id":943,"createTime":24,"updateTime":24,"relativeEntities":963,"slug":24,"properties":964,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":966,"statistic":24},[],{"title":965},{"EN":948},[],{"orcid":968,"title":970,"gsAuthor":972,"openalex":974},{"VOID":969},"https:\u002F\u002Forcid.org\u002F0000-0001-9980-4225",{"EN":971},"Nicholas R. J. Gascoigne",{"VOID":973},"[\"vFpsn7EAAAAJ\"]",{"VOID":975},"A5055497014",{"url":24,"publisher":977,"properties":1024},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":978,"slug":10,"properties":979,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":984,"manageAffiliations":993,"indexDatabases":1004,"url":90,"thumbnailPath":24,"statistic":1019,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":980,"eissn":981,"issn":982,"title":983},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[985,989],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":986,"label":987,"description":988,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":990,"label":991,"description":992,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[994,999],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":995,"slug":24,"properties":996,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":998,"statistic":24},[],{"title":997},{"EN":45},[],{"id":48,"createTime":24,"updateTime":24,"relativeEntities":1000,"slug":24,"properties":1001,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1003,"statistic":24},[],{"title":1002},{"EN":52},[],[1005,1012],{"id":56,"indexDatabase":1006,"url":69,"indexYears":24,"academicFieldIds":1011,"indexDatabaseRanking":24},{"id":58,"createTime":24,"updateTime":24,"relativeEntities":1007,"label":1008,"description":1009,"key":65,"publicationTags":1010,"standard":24},[],{"EN":61,"VI":61},{"EN":63,"VI":64},[67,68],[71],{"id":73,"indexDatabase":1013,"url":84,"indexYears":85,"academicFieldIds":1018,"indexDatabaseRanking":89},{"id":75,"createTime":24,"updateTime":24,"relativeEntities":1014,"label":1015,"description":1016,"key":81,"publicationTags":1017,"standard":24},[],{"EN":78,"VI":78},{"EN":78,"VI":80},[83],[87,88],{"impactFactor":25,"impactFactorByYear":1020,"i10Index":105,"i10IndexLast5Year":106,"totalPublication":107,"totalPublicationByYear":1021,"totalCitation":145,"totalCitationByYear":1022,"totalCitationPerPublication":210,"totalCitationPerPublicationByYear":1023,"hindexLast5Year":208,"hindex":208},{"2012":93,"2013":94,"2014":95,"2015":96,"2016":97,"2017":98,"2018":99,"2019":100,"2020":101,"2021":102,"2022":103,"2023":104},{"1938":109,"1940":110,"1946":109,"1954":110,"1956":109,"1958":110,"1959":110,"1963":110,"1965":111,"1966":112,"1967":110,"1968":112,"1969":112,"1970":111,"1971":112,"1972":113,"1973":112,"1974":111,"1975":114,"1976":115,"1977":116,"1978":115,"1979":106,"1980":117,"1981":114,"1982":115,"1983":118,"1984":106,"1985":119,"1986":120,"1987":118,"1988":121,"1989":117,"1990":122,"1991":123,"1992":124,"1993":125,"1994":126,"1995":127,"1996":128,"1997":129,"1998":130,"1999":131,"2000":132,"2001":133,"2002":134,"2003":135,"2004":135,"2005":136,"2006":137,"2007":138,"2008":139,"2009":128,"2010":140,"2011":141,"2012":128,"2013":142,"2014":121,"2015":119,"2016":120,"2017":102,"2018":143,"2020":102,"2021":144,"2022":110},{"1938":147,"1940":148,"1946":124,"1954":149,"1956":150,"1958":151,"1959":152,"1963":153,"1965":154,"1966":155,"1967":156,"1968":157,"1969":158,"1970":159,"1971":160,"1972":161,"1973":162,"1974":163,"1975":164,"1976":165,"1977":166,"1978":167,"1979":168,"1980":169,"1981":170,"1982":171,"1983":172,"1984":173,"1985":174,"1986":175,"1987":176,"1988":177,"1989":178,"1990":179,"1991":180,"1992":181,"1993":182,"1994":183,"1995":184,"1996":185,"1997":186,"1998":187,"1999":188,"2000":189,"2001":190,"2002":191,"2003":192,"2004":193,"2005":194,"2006":195,"2007":196,"2008":197,"2009":198,"2010":199,"2011":200,"2012":201,"2013":202,"2014":203,"2015":204,"2016":205,"2017":206,"2018":207,"2020":208,"2021":209,"2022":109},{"1938":212,"1940":148,"1946":213,"1954":149,"1956":214,"1958":151,"1959":152,"1963":153,"1965":215,"1966":216,"1967":156,"1968":217,"1969":218,"1970":219,"1971":220,"1972":221,"1973":222,"1974":223,"1975":224,"1976":225,"1977":226,"1978":227,"1979":228,"1980":229,"1981":230,"1982":231,"1983":232,"1984":233,"1985":234,"1986":235,"1987":236,"1988":237,"1989":238,"1990":239,"1991":240,"1992":241,"1993":242,"1994":243,"1995":244,"1996":245,"1997":246,"1998":247,"1999":248,"2000":249,"2001":250,"2002":251,"2003":252,"2004":253,"2005":254,"2006":255,"2007":256,"2008":257,"2009":258,"2010":259,"2011":260,"2012":261,"2013":262,"2014":263,"2015":264,"2016":265,"2017":266,"2018":267,"2020":268,"2021":269,"2022":109},{"issue":1025,"pages":1027,"volume":1029},{"VOID":1026},"8",{"VOID":1028},"3883-3890",{"VOID":1030},"160",{"total":25,"publishYear":1032,"statisticByYear":1033},1998,{},"1998-04-15",[67,89],[1037,1041,1045,1049,1053,1057,1061,1065,1069,1073,1077,1081,1085,1089,1093,1097,1101,1105,1109,1113,1117,1121,1125,1129,1133,1137,1141,1145,1149,1153,1157,1161,1165,1169],{"id":24,"text":1038,"url":24,"identifiers":1039},"Malissen, M.,  J. Trucy,  E. Jouvin-Marche,  P.-A. Cazenave,  R. Scollay,  B. Malissen.  1992. Regulation of TCR α and β gene allelic exclusion during T-cell development. Immunol. Today 13: 315",{"doi":1040},"10.1016\u002F0167-5699(92)90044-8",{"id":24,"text":1042,"url":24,"identifiers":1043},"Fehling, H. J.,  H. von Boehmer.  1997. Early αβ T cell development in the thymus of normal and genetically altered mice. Curr. Opin. Immunol. 9: 263",{"doi":1044},"10.1016\u002FS0952-7915(97)80146-X",{"id":24,"text":1046,"url":24,"identifiers":1047},"Kouskoff, V.,  J.-L. Vonesch,  C. Benoist,  D. Mathis.  1995. The influence of positive selection on RAG expression in thymocytes. Eur. J. Immunol. 25: 54",{"doi":1048},"10.1002\u002Feji.1830250111",{"id":24,"text":1050,"url":24,"identifiers":1051},"Borgulya, P.,  H. Kishi,  Y. Uematsu,  H. von Boehmer.  1992. Exclusion and inclusion of α and β T cell receptor alleles. Cell 69: 529",{"doi":1052},"10.1016\u002F0092-8674(92)90453-J",{"id":24,"text":1054,"url":24,"identifiers":1055},"Brandle, D.,  C. Muller,  T. Rulicke,  H. Hengartner,  H. Pircher.  1992. Engagement of the T cell receptor during positive selection in the thymus down-regulates RAG-1 expression. Proc. Natl. Acad. Sci. USA 89: 9529",{"doi":1056},"10.1073\u002Fpnas.89.20.9529",{"id":24,"text":1058,"url":24,"identifiers":1059},"Marolleau, J.-P.,  J. D. Fondell,  M. Malissen,  J. Trucy,  E. Barbier,  K. B. Marcu,  P.-A. Cazenave,  D. Primi.  1988. The joining of germ-line Vα to Jα genes replaces the preexisting Vα-Jα complexes in a T cell receptor α,β positive T cell line. Cell 55: 291",{"doi":1060},"10.1016\u002F0092-8674(88)90052-9",{"id":24,"text":1062,"url":24,"identifiers":1063},"Petrie, H. T.,  F. Livak,  D. G. Schatz,  A. Strasser,  I. N. Crispe,  K. Shortman.  1993. Multiple rearrangements in T cell receptor α chain genes maximize the production of useful thymocytes. J. Exp. Med. 178: 615",{"doi":1064},"10.1084\u002Fjem.178.2.615",{"id":24,"text":1066,"url":24,"identifiers":1067},"Alam, S. M.,  I. N. Crispe,  N. R. J. Gascoigne.  1995. Allelic exclusion of mouse T cell receptor α chains occurs at the time of thymocyte TCR up-regulation. Immunity 3: 449",{"doi":1068},"10.1016\u002F1074-7613(95)90174-4",{"id":24,"text":1070,"url":24,"identifiers":1071},"Malissen, M.,  J. Trucy,  F. Letourneur,  N. Rebaï,  D. E. Dunn,  F. W. Fitch,  L. Hood,  B. Malissen.  1988. A T cell clone expresses two T cell receptor α genes but uses one αβ heterodimer for allorecognition and self MHC-restricted antigen recognition. Cell 55: 49",{"doi":1072},"10.1016\u002F0092-8674(88)90008-6",{"id":24,"text":1074,"url":24,"identifiers":1075},"Casanova, J.-L.,  P. Romero,  C. Widmann,  P. Kourilsky,  J. L. Maryanski.  1991. T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T cell clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire. J. Exp. Med. 174: 1371",{"doi":1076},"10.1084\u002Fjem.174.6.1371",{"id":24,"text":1078,"url":24,"identifiers":1079},"Kuida, K.,  M. Furutani-Seiki,  T. Saito,  H. Kishimoto,  K. Sano,  T. Tada.  1991. Post-translational attainment of allelic exclusion of the T cell receptor α chain in a T cell clone. Int. Immunol. 3: 75",{"doi":1080},"10.1093\u002Fintimm\u002F3.1.75",{"id":24,"text":1082,"url":24,"identifiers":1083},"Couez, D.,  M. Malissen,  M. Buferne,  A.-M. Schmitt-Verhulst,  B. Malissen.  1991. Each of the two productive T cell receptor α-gene rearrangements found in both the A10 and BM 3.3 T cell clones give rise to an α chain which can contribute to the constitution of a surface-expressed αβ dimer. Int. Immunol. 3: 719",{"doi":1084},"10.1093\u002Fintimm\u002F3.7.719",{"id":24,"text":1086,"url":24,"identifiers":1087},"Kearse, K. P.,  J. L. Roberts,  T. I. Munitz,  D. L. Wiest,  T. Nakayama,  A. Singer.  1994. Developmental regulation of αβ T cell antigen receptor expression results from differential stability of nascent TCRα proteins within the endoplasmic reticulum of immature and mature T cells. EMBO J. 13: 4504",{"doi":1088},"10.1002\u002Fj.1460-2075.1994.tb06772.x",{"id":24,"text":1090,"url":24,"identifiers":1091},"Kearse, K. P.,  Y. Takahama,  J. A. Punt,  S. O. Sharrow,  A. Singer.  1995. Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+CD8+ thymocytes: increased synthesis of TCR-α protein is an early response to TCR signaling that compensates for TCR-α instability, improves TCR assembly, and parallels other indicators of positive selection. J. Exp. Med. 181: 193",{"doi":1092},"10.1084\u002Fjem.181.1.193",{"id":24,"text":1094,"url":24,"identifiers":1095},"Kosugi, A.,  A. M. Weissman,  M. Ogata,  T. Hamaoka,  H. Fujiwara.  1992. Instability of assembled T-cell receptor complex that is associated with rapid degradation of ζ chains in immature CD4+CD8+ thymocytes. Proc. Natl. Acad. Sci. USA 89: 9494",{"doi":1096},"10.1073\u002Fpnas.89.20.9494",{"id":24,"text":1098,"url":24,"identifiers":1099},"Havran, W. L.,  M. Poenie,  J. Kimura,  R. Tsien,  A. Weiss,  J. P. Allison.  1987. Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes. Nature 330: 170",{"doi":1100},"10.1038\u002F330170a0",{"id":24,"text":1102,"url":24,"identifiers":1103},"Crispe, I. N.,  R. P. Shimonkevitz,  L. A. Husmann,  J. Kimura,  J. P. Allison.  1987. Expression of T cell antigen receptor β-chains on subsets of mouse thymocytes: analysis by three-color flow cytometry. J. Immunol. 139: 3585",{"doi":1104},"10.4049\u002Fjimmunol.139.11.3585",{"id":24,"text":1106,"url":24,"identifiers":1107},"Padovan, E.,  G. Casorati,  P. Dellabona,  S. Meyer,  M. Brockhaus,  A. Lanzavecchia.  1993. Expression of two T cell receptor α chains: dual receptor T cells. Science 262: 422",{"doi":1108},"10.1126\u002Fscience.8211163",{"id":24,"text":1110,"url":24,"identifiers":1111},"Heath, W. R.,  F. R. Carbone,  P. Bertolino,  J. Kelly,  S. Cose,  J. F. A. P. Miller.  1995. Expression of two T cell receptor α chains on the surface of normal murine T cells. Eur. J. Immunol. 25: 1617",{"doi":1112},"10.1002\u002Feji.1830250622",{"id":24,"text":1114,"url":24,"identifiers":1115},"Elliott, J. I.,  D. M. Altmann.  1995. Dual T cell receptor α chain T cells in autoimmunity. J. Exp. Med. 182: 953",{"doi":1116},"10.1084\u002Fjem.182.4.953",{"id":24,"text":1118,"url":24,"identifiers":1119},"Mombaerts, P.,  A. R. Clarke,  M. A. Rudnicki,  J. Iacomini,  S. Itohara,  J. Lafaille,  L. Wang,  Y. Ichikawa,  R. Jaenisch,  M. L. Hooper,  S. Tonegawa.  1992. Mutations in T cell receptor genes α and β block thymocyte development at different stages. Nature 360: 225",{"doi":1120},"10.1038\u002F360225a0",{"id":24,"text":1122,"url":24,"identifiers":1123},"Pircher, H.,  N. Rebaï,  M. Groettrup,  C. Grégoire,  D. E. Speiser,  M. P. Happ,  E. Palmer,  R. M. Zinkernagel,  H. Hengartner,  B. Malissen.  1992. Preferential positive selection of Vα2+CD8+ T cells in mouse strains expressing both H-2k and T cell receptor Vαa haplotypes: determination with a Vα2-specific monoclonal antibody. Eur. J. Immunol. 22: 399",{"doi":1124},"10.1002\u002Feji.1830220217",{"id":24,"text":1126,"url":24,"identifiers":1127},"Utsunomiya, Y.,  J. Bill,  E. Palmer,  K. Gollob,  Y. Takagaki,  O. Kanagawa.  1989. Analysis of a monoclonal rat antibody directed to the α-chain variable region (Vα3) of the mouse T cell antigen receptor. J. Immunol. 143: 2602",{"doi":1128},"10.4049\u002Fjimmunol.143.8.2602",{"id":24,"text":1130,"url":24,"identifiers":1131},"Necker, A.,  N. Rebaï,  M. Matthes,  E. Jouvin-Marche,  P.-A. Cazenave,  P. Swarnworawong,  E. Palmer,  H. R. MacDonald,  B. Malissen.  1991. Monoclonal antibodies raised against engineered soluble mouse T cell receptors and specific for Vα8-, Vβ2-, or Vβ10-bearing T cells. Eur. J. Immunol. 21: 3035",{"doi":1132},"10.1002\u002Feji.1830211220",{"id":24,"text":1134,"url":24,"identifiers":1135},"Jameson, S. C.,  P. B. Nakajima,  J. L. Brooks,  W. Heath,  O. Kanagawa,  N. R. J. Gascoigne.  1991. The T cell receptor Vα11 gene family: analysis of allelic sequence polymorphism and demonstration of Jα region-dependent recognition by allele-specific antibodies. J. Immunol. 147: 3185",{"doi":1136},"10.4049\u002Fjimmunol.147.9.3185",{"id":24,"text":1138,"url":24,"identifiers":1139},"Kubo, R. T.,  W. Born,  J. W. Kappler,  P. Marrack,  M. Pigeon.  1989. Characterization of a monoclonal antibody which detects all murine αβ T cell receptors. J. Immunol. 142: 2736",{"doi":1140},"10.4049\u002Fjimmunol.142.8.2736",{"id":24,"text":1142,"url":24,"identifiers":1143},"Gascoigne, N. R. J..  1990. Transport and secretion of truncated T cell receptor β-chain occurs in the absence of association with CD3. J. Biol. Chem. 265: 9296",{"doi":1144},"10.1016\u002FS0021-9258(19)38847-7",{"id":24,"text":1146,"url":24,"identifiers":1147},"Alam, S. M.,  P. Whitford,  W. Cushley,  W. D. George,  A. M. Campbell.  1992. Aneuploid subpopulations in tumour-invaded lymph nodes from breast cancer patients. Eur. J. Cancer 28: 357",{"doi":1148},"10.1016\u002FS0959-8049(05)80053-X",{"id":24,"text":1150,"url":24,"identifiers":1151},"Klausner, R. D.,  J. Lippincott-Schwartz,  J. S. Bonifacino.  1990. The T cell antigen receptor: insights into organelle biology. Annu. Rev. Cell Biol. 6: 403",{"doi":1152},"10.1146\u002Fannurev.cb.06.110190.002155",{"id":24,"text":1154,"url":24,"identifiers":1155},"Mason, D..  1994. Allelic exclusion of α chains in TCRs. Int. Immunol. 6: 881",{"doi":1156},"10.1093\u002Fintimm\u002F6.6.881",{"id":24,"text":1158,"url":24,"identifiers":1159},"Hardardottir, F.,  J. L. Baron,  C. A. Janeway, Jr.  1995. T cells with two functional antigen-specific receptors. Proc. Natl. Acad. Sci. USA 92: 354",{"doi":1160},"10.1073\u002Fpnas.92.2.354",{"id":24,"text":1162,"url":24,"identifiers":1163},"Zal, T.,  A. Volkmann,  B. Stockinger.  1994. Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen. J. Exp. Med. 180: 2089",{"doi":1164},"10.1084\u002Fjem.180.6.2089",{"id":24,"text":1166,"url":24,"identifiers":1167},"Elliott, J. I.,  D. M. Altmann.  1996. Non-obese diabetic mice hemizygous at the T cell receptor α locus are susceptible to diabetes and sialitis. Eur. J. Immunol. 26: 953",{"doi":1168},"10.1002\u002Feji.1830260436",{"id":24,"text":1170,"url":24,"identifiers":1171},"Zal, T.,  S. Weiss,  A. Mellor,  A. Stockinger.  1996. Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function. Proc. Natl. Acad. Sci. USA 93: 9102",{"doi":1172},"10.1073\u002Fpnas.93.17.9102",{"id":1174,"createTime":1175,"updateTime":1176,"relativeEntities":1177,"slug":1178,"properties":1179,"entityType":295,"verifyStatus":296,"verifyTime":1175,"verifyNote":297,"languages":1194,"translateLanguages":24,"viewCount":25,"primaryUrl":1195,"fullTextUrl":24,"authors":1196,"publicationType":423,"publisherRelationship":1290,"citationCount":25,"citationInfo":1345,"publishDate":1348,"publishYear":1346,"citationAnalyzeStatus":915,"lastCitationAnalyze":1349,"indexDatabases":1350,"openAccess":24,"references":1351,"isForceReanalyzing":615},"293a2fa4-921f-4afd-8165-a9f326b96049","2024-09-25T02:24:22.162+00:00","2026-07-24T02:43:31.354+00:00",[],"Veto-Like-Activity-of-Mesenchymal-Stem-Cells-Functional-Discrimination-Between-Cellular-Responses-to-Alloantigens-and-Recall-Antigens",{"mag":1180,"gsPaper":1182,"openalex":1184,"abstract":1186,"title":1188,"pm":1190,"doi":1192},{"VOID":1181},"2150977474",{"VOID":1183},"[\"13191457782102582751\"]",{"VOID":1185},"W2150977474",{"EN":1187},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:p>Trans-differentiation of stem cells shows promise for use in tissue repair medicine. Although poorly defined, mesenchymal stem cells (MSC) appear useful for applications in repair medicine. Despite the low frequency of MSC, they are relatively easy to expand. The expression of MHC class II on MSC, however, could deter their use in repair medicine, since these molecules could stimulate an allogeneic host response. This study sought to compare the immune stimulatory and suppressive effects of MSC. Primary human MSC were cultured from bone marrow aspirates and then passaged at least three times before use in assays. Morphologically, MSC were symmetrical; were SH2+, MHC class II+, CD45−, CD44+, CD31−, CD14−, proly-4-hydroxylase−; and showed normal karyotype patterns and elevated telomerase activities. MSC elicited significant stimulatory responses when cocultured with allogeneic PBMC. Despite the production of different types of growth factors, allogeneic effects of MSC could not be explained by the production of these growth factors. One-way MLR reactions were significantly blunted by third-party MSC. Similar suppression was not observed for responses to three different recall Ags. Based on these functional differences by MSC in responses to allo- and recall Ags, we examined whether MSC could exert veto-like functions. We showed that MSC could blunt the cytotoxic effects of allogeneic-induced effectors to mitogen-activated targets. The results showed that although MSC elicited allogeneic responses in a model that mimics a graft-vs-host reaction, they also exerted veto-like activity, but caused no effect on responses to recall Ags.\u003C\u002Fjats:p>",{"EN":1189},"Veto-Like Activity of Mesenchymal Stem Cells: Functional Discrimination Between Cellular Responses to Alloantigens and Recall Antigens",{"VOID":1191},"14500637",{"VOID":1193},"10.4049\u002Fjimmunol.171.7.3426",[299],"https:\u002F\u002Fjournals.aai.org\u002Fjimmunol\u002Farticle\u002F171\u002F7\u002F3426\u002F71530\u002FVeto-Like-Activity-of-Mesenchymal-Stem-Cells",[1197,1222,1239,1256,1273],{"id":1198,"sortIndex":25,"researcher":24,"roles":1199,"affiliations":1200,"properties":1217,"displayName":1219,"givenName":24,"familyName":24},"d34cb0c5-7cad-4688-a93d-c85ffcd13b3e",[],[1201,1209],{"id":1202,"sortIndex":25,"affiliation":1203,"properties":24},"25ed5ef8-8ecf-477d-97b2-c839197e1faa",{"id":1202,"createTime":24,"updateTime":24,"relativeEntities":1204,"slug":24,"properties":1205,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1208,"statistic":24},[],{"title":1206},{"EN":1207},"* Medicine-Hematology\u002FOncology,",[],{"id":1210,"sortIndex":110,"affiliation":1211,"properties":24},"8b9081be-92b5-4d36-a05c-fc5d9046bc3e",{"id":1210,"createTime":24,"updateTime":24,"relativeEntities":1212,"slug":24,"properties":1213,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1216,"statistic":24},[],{"title":1214},{"EN":1215},"§University of Medicine and Dentistry of New Jersey-Graduate School of Biomedical Sciences, Newark, NJ 07103",[],{"title":1218,"openalex":1220},{"EN":1219},"Julius A. Potian",{"VOID":1221},"A5026539023",{"id":1223,"sortIndex":110,"researcher":24,"roles":1224,"affiliations":1225,"properties":1234,"displayName":1236,"givenName":24,"familyName":24},"ee0c481d-0818-4cf0-a390-fdd2c6a4cc61",[],[1226],{"id":1227,"sortIndex":25,"affiliation":1228,"properties":24},"91507d6f-f660-4d5e-86b5-d3385ee04710",{"id":1227,"createTime":24,"updateTime":24,"relativeEntities":1229,"slug":24,"properties":1230,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1233,"statistic":24},[],{"title":1231},{"VI":1232},"Pediatrics, and",[],{"title":1235,"openalex":1237},{"EN":1236},"Hana Aviv",{"VOID":1238},"A5035676198",{"id":1240,"sortIndex":109,"researcher":24,"roles":1241,"affiliations":1242,"properties":1251,"displayName":1253,"givenName":24,"familyName":24},"ded1106c-4db1-4e23-b561-c5f7c903d159",[],[1243],{"id":1244,"sortIndex":25,"affiliation":1245,"properties":24},"60771b87-e7c0-4b76-8267-a156413e568b",{"id":1244,"createTime":24,"updateTime":24,"relativeEntities":1246,"slug":24,"properties":1247,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1250,"statistic":24},[],{"title":1248},{"EN":1249},"‡Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey; and",[],{"title":1252,"openalex":1254},{"EN":1253},"Nicholas M. Ponzio",{"VOID":1255},"A5017916363",{"id":1257,"sortIndex":111,"researcher":24,"roles":1258,"affiliations":1259,"properties":1266,"displayName":1270,"givenName":24,"familyName":24},"bba02315-3cde-46bb-9d10-5dfb926f82eb",[],[1260],{"id":1202,"sortIndex":25,"affiliation":1261,"properties":24},{"id":1202,"createTime":24,"updateTime":24,"relativeEntities":1262,"slug":24,"properties":1263,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1265,"statistic":24},[],{"title":1264},{"EN":1207},[],{"orcid":1267,"title":1269,"openalex":1271},{"VOID":1268},"https:\u002F\u002Forcid.org\u002F0000-0002-5815-709X",{"EN":1270},"Jonathan S. Harrison",{"VOID":1272},"A5029065397",{"id":1274,"sortIndex":112,"researcher":24,"roles":1275,"affiliations":1276,"properties":1283,"displayName":1287,"givenName":24,"familyName":24},"58ae1b26-aa8d-4fe4-8475-9dbcaa087267",[],[1277],{"id":1202,"sortIndex":25,"affiliation":1278,"properties":24},{"id":1202,"createTime":24,"updateTime":24,"relativeEntities":1279,"slug":24,"properties":1280,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1282,"statistic":24},[],{"title":1281},{"EN":1207},[],{"orcid":1284,"title":1286,"openalex":1288},{"VOID":1285},"https:\u002F\u002Forcid.org\u002F0000-0003-0434-9034",{"EN":1287},"Pranela Rameshwar",{"VOID":1289},"A5085147005",{"url":24,"publisher":1291,"properties":1338},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1292,"slug":10,"properties":1293,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1298,"manageAffiliations":1307,"indexDatabases":1318,"url":90,"thumbnailPath":24,"statistic":1333,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1294,"eissn":1295,"issn":1296,"title":1297},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[1299,1303],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":1300,"label":1301,"description":1302,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":1304,"label":1305,"description":1306,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[1308,1313],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":1309,"slug":24,"properties":1310,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1312,"statistic":24},[],{"title":1311},{"EN":45},[],{"id":48,"createTime":24,"updateTime":24,"relativeEntities":1314,"slug":24,"properties":1315,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1317,"statistic":24},[],{"title":1316},{"EN":52},[],[1319,1326],{"id":56,"indexDatabase":1320,"url":69,"indexYears":24,"academicFieldIds":1325,"indexDatabaseRanking":24},{"id":58,"createTime":24,"updateTime":24,"relativeEntities":1321,"label":1322,"description":1323,"key":65,"publicationTags":1324,"standard":24},[],{"EN":61,"VI":61},{"EN":63,"VI":64},[67,68],[71],{"id":73,"indexDatabase":1327,"url":84,"indexYears":85,"academicFieldIds":1332,"indexDatabaseRanking":89},{"id":75,"createTime":24,"updateTime":24,"relativeEntities":1328,"label":1329,"description":1330,"key":81,"publicationTags":1331,"standard":24},[],{"EN":78,"VI":78},{"EN":78,"VI":80},[83],[87,88],{"impactFactor":25,"impactFactorByYear":1334,"i10Index":105,"i10IndexLast5Year":106,"totalPublication":107,"totalPublicationByYear":1335,"totalCitation":145,"totalCitationByYear":1336,"totalCitationPerPublication":210,"totalCitationPerPublicationByYear":1337,"hindexLast5Year":208,"hindex":208},{"2012":93,"2013":94,"2014":95,"2015":96,"2016":97,"2017":98,"2018":99,"2019":100,"2020":101,"2021":102,"2022":103,"2023":104},{"1938":109,"1940":110,"1946":109,"1954":110,"1956":109,"1958":110,"1959":110,"1963":110,"1965":111,"1966":112,"1967":110,"1968":112,"1969":112,"1970":111,"1971":112,"1972":113,"1973":112,"1974":111,"1975":114,"1976":115,"1977":116,"1978":115,"1979":106,"1980":117,"1981":114,"1982":115,"1983":118,"1984":106,"1985":119,"1986":120,"1987":118,"1988":121,"1989":117,"1990":122,"1991":123,"1992":124,"1993":125,"1994":126,"1995":127,"1996":128,"1997":129,"1998":130,"1999":131,"2000":132,"2001":133,"2002":134,"2003":135,"2004":135,"2005":136,"2006":137,"2007":138,"2008":139,"2009":128,"2010":140,"2011":141,"2012":128,"2013":142,"2014":121,"2015":119,"2016":120,"2017":102,"2018":143,"2020":102,"2021":144,"2022":110},{"1938":147,"1940":148,"1946":124,"1954":149,"1956":150,"1958":151,"1959":152,"1963":153,"1965":154,"1966":155,"1967":156,"1968":157,"1969":158,"1970":159,"1971":160,"1972":161,"1973":162,"1974":163,"1975":164,"1976":165,"1977":166,"1978":167,"1979":168,"1980":169,"1981":170,"1982":171,"1983":172,"1984":173,"1985":174,"1986":175,"1987":176,"1988":177,"1989":178,"1990":179,"1991":180,"1992":181,"1993":182,"1994":183,"1995":184,"1996":185,"1997":186,"1998":187,"1999":188,"2000":189,"2001":190,"2002":191,"2003":192,"2004":193,"2005":194,"2006":195,"2007":196,"2008":197,"2009":198,"2010":199,"2011":200,"2012":201,"2013":202,"2014":203,"2015":204,"2016":205,"2017":206,"2018":207,"2020":208,"2021":209,"2022":109},{"1938":212,"1940":148,"1946":213,"1954":149,"1956":214,"1958":151,"1959":152,"1963":153,"1965":215,"1966":216,"1967":156,"1968":217,"1969":218,"1970":219,"1971":220,"1972":221,"1973":222,"1974":223,"1975":224,"1976":225,"1977":226,"1978":227,"1979":228,"1980":229,"1981":230,"1982":231,"1983":232,"1984":233,"1985":234,"1986":235,"1987":236,"1988":237,"1989":238,"1990":239,"1991":240,"1992":241,"1993":242,"1994":243,"1995":244,"1996":245,"1997":246,"1998":247,"1999":248,"2000":249,"2001":250,"2002":251,"2003":252,"2004":253,"2005":254,"2006":255,"2007":256,"2008":257,"2009":258,"2010":259,"2011":260,"2012":261,"2013":262,"2014":263,"2015":264,"2016":265,"2017":266,"2018":267,"2020":268,"2021":269,"2022":109},{"issue":1339,"pages":1341,"volume":1343},{"VOID":1340},"7",{"VOID":1342},"3426-3434",{"VOID":1344},"171",{"total":25,"publishYear":1346,"statisticByYear":1347},2003,{},"2003-10-01","2026-07-24T02:43:31.353+00:00",[67,89],[1352,1356,1360,1364,1368,1372,1376,1380,1384,1388,1392,1396,1400,1404,1408,1412,1416,1420,1424,1428,1432,1436,1440,1444,1448,1452,1456,1460,1464,1468,1472,1476,1480,1484,1488,1492,1496,1500,1504,1508,1512,1516,1520],{"id":24,"text":1353,"url":24,"identifiers":1354},"Zon, L. I..  1995. Developmental biology of hematopoiesis. Blood 86:2876.",{"doi":1355},"10.1182\u002Fblood.V86.8.2876.bloodjournal8682876",{"id":24,"text":1357,"url":24,"identifiers":1358},"Deans, R. J.,  A. B. Moseley.  2000. Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol. 28:875.",{"doi":1359},"10.1016\u002FS0301-472X(00)00482-3",{"id":24,"text":1361,"url":24,"identifiers":1362},"Jiang, Y.,  B. N. Jahagirdar,  R. L. Reinhardt,  R. E. Schwartz,  C. D. Keene,  R. Ortiz-Gonzalez,  M. Reyes,  T. Lenvik,  T. Lund,  M. Blackstad, et al 2002. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418:41.",{"doi":1363},"10.1038\u002Fnature00870",{"id":24,"text":1365,"url":24,"identifiers":1366},"Arai, F.,  O. Ohneda,  T. Miyamoto,  X. Q. Zhang,  T. Suda.  2002. Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation. J. Exp. Med. 195:1549.",{"doi":1367},"10.1084\u002Fjem.20011700",{"id":24,"text":1369,"url":24,"identifiers":1370},"Bianco, P.,  M. Riminucci,  S. Gronthos,  P. G. Robey.  2001. Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 19:180.",{"doi":1371},"10.1634\u002Fstemcells.19-3-180",{"id":24,"text":1373,"url":24,"identifiers":1374},"Campagnoli, C.,  I. A. G. Roberts,  S. Kumar,  P. R. Bennett,  I. Bellantuono,  N. M. Fisk.  2002. Identification of mesenchymal stem\u002Fprogenitor cells in human first-trimester fetal blood, liver, and bone marrow. Blood 98:2396.",{"doi":1375},"10.1182\u002Fblood.V98.8.2396",{"id":24,"text":1377,"url":24,"identifiers":1378},"Pittenger, M. F.,  A. M. Mackay,  S. C. Beck,  R. K. Jaiswal,  R. Douglas,  J. D. Mosca,  M. A. Moorman,  D. W. Simonetti,  S. Craig,  D. R. Marshak.  1999. Multilineage potential of adult human mesenchymal stem cells. Science 284:143.",{"doi":1379},"10.1126\u002Fscience.284.5411.143",{"id":24,"text":1381,"url":24,"identifiers":1382},"Akashi, K.,  D. Traver,  T. Miyamotot,  I. L. Weissman.  2000. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404:193.",{"doi":1383},"10.1038\u002F35004599",{"id":24,"text":1385,"url":24,"identifiers":1386},"Chow, D. C.,  L. A. Wenning,  W. M. Miller,  E. T. Papoutsakis.  2001. Modeling pO2 distributions in the bone marrow hematopoietic compartment. I. Krogh’s model. Biophys. J. 81:675.",{"doi":1387},"10.1016\u002FS0006-3495(01)75732-3",{"id":24,"text":1389,"url":24,"identifiers":1390},"Chow, D. C.,  L. A. Wenning,  W. M. Miller,  E. T. Papoutsakis.  2001. Modeling pO2 distributions in the bone marrow hematopoietic compartment. II. Modified Kroghian models. Biophys. J. 81:685.",{"doi":1391},"10.1016\u002FS0006-3495(01)75733-5",{"id":24,"text":1393,"url":24,"identifiers":1394},"Harrison, J. S.,  P. Rameshwar,  V. Chang,  P. Bandari.  2002. Oxygen saturation in the bone marrow of healthy volunteers. Blood 99:394.",{"doi":1395},"10.1182\u002Fblood.V99.1.394",{"id":24,"text":1397,"url":24,"identifiers":1398},"Hawley, R. G.,  D. A. Sobieski.  2002. Somatic stem cell plasticity: to be or not to be. Stem Cells 20:195.",{"doi":1399},"10.1634\u002Fstemcells.20-3-195",{"id":24,"text":1401,"url":24,"identifiers":1402},"D’Amour, K. A.,  F. H. Gage.  2002. Are somatic stem cells pluripotent or lineage-restricted?. Nat. Med. 8:213.",{"doi":1403},"10.1038\u002Fnm0302-213",{"id":24,"text":1405,"url":24,"identifiers":1406},"Schwartz, R. E.,  M. Reyes,  L. Koodie,  Y. Jiang,  M. Blackstad,  T. Lund,  T. Lenvik,  S. Johnson,  W. S. Hu,  C. M. Verfaille.  2002. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J. Clin. Invest. 109:1291.",{"doi":1407},"10.1172\u002FJCI0215182",{"id":24,"text":1409,"url":24,"identifiers":1410},"Jin, H. K.,  J. E. Carter,  G. W. Huntley,  E. H. Schuchman.  2002. Intracerebral transplantation of mesenchymal stem cells into acid sphingomyelinase-deficient mice delays the onset of neurological abnormalities and extends their life span. J. Clin. Invest. 109:1183.",{"doi":1411},"10.1172\u002FJCI14862",{"id":24,"text":1413,"url":24,"identifiers":1414},"Devine, S. M.,  A. M. Bartholomew,  N. Mahmud,  M. Nelson,  S. Patil,  W. Hardy,  C. Sturgeon,  T. Hewett,  T. Chung,  W. Stock, et al 2001. Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusion. Exp. Hematol. 29:244.",{"doi":1415},"10.1016\u002FS0301-472X(00)00635-4",{"id":24,"text":1417,"url":24,"identifiers":1418},"Lemischka, I..  2002. A few thoughts about plasticity of stem cells. Exp. Hematol. 30:848.",{"doi":1419},"10.1016\u002FS0301-472X(02)00876-7",{"id":24,"text":1421,"url":24,"identifiers":1422},"Sanchez-Ramos, J.,  S. Song,  F. Cardozo-Pelaez,  C Hazzi,  T. Stedeford,  A. Willing,  T. B. Freeman,  S. Saporta,  W. Janssen,  N. Patel, et al 2000. Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp. Neurol. 164:247.",{"doi":1423},"10.1006\u002Fexnr.2000.7389",{"id":24,"text":1425,"url":24,"identifiers":1426},"Woodbury, D.,  E. Schwarz,  D. Prockop,  I. Black.  2000. Adult rat and human bone marrow stromal cells differentiate into neurons. J. Neurosci. Res. 61:364.",{"doi":1427},"10.1002\u002F1097-4547(20000815)61:4\u003C364::AID-JNR2>3.0.CO;2-C",{"id":24,"text":1429,"url":24,"identifiers":1430},"Kopen, G. C.,  D. J. Prockop,  D. G. Phinney.  1999. Marrow stromal cells migrate through forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc. Natl. Acad. Sci. USA 96:10711.",{"doi":1431},"10.1073\u002Fpnas.96.19.10711",{"id":24,"text":1433,"url":24,"identifiers":1434},"Azizi, S. A.,  D. Stokes,  B. J. Augelli,  C. DiGirolamo,  D. J. Prockop.  1998. Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats: similarities to astrocyte grafts. Proc. Natl. Acad. Sci. USA 95:3908.",{"doi":1435},"10.1073\u002Fpnas.95.7.3908",{"id":24,"text":1437,"url":24,"identifiers":1438},"Wakitani, S.,  T. Saito,  A. I. Caplan.  1995. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve 18:1417.",{"doi":1439},"10.1002\u002Fmus.880181212",{"id":24,"text":1441,"url":24,"identifiers":1442},"Gerson, S. L..  1999. Mesenchymal stem cells: no longer second class marrow citizens. Nat. Med. 5:262.",{"doi":1443},"10.1038\u002F6470",{"id":24,"text":1445,"url":24,"identifiers":1446},"Caplan, A. I.,  S. R. Bruder.  2001. Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends Mol. Med. 7:259.",{"doi":1447},"10.1016\u002FS1471-4914(01)02016-0",{"id":24,"text":1449,"url":24,"identifiers":1450},"Botella, L. M.,  T. Sanchez-Elsner,  F. Sanz-Rodriguez,  S. Kojima,  J. Shimada,  M. Guerrero-Esteo,  M. P. Cooreman,  V. Ratziu,  C. Langa,  C. P. H Vary, et al 2002. Transcriptional activation of endoglin and transforming growth factor-β signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury. Blood 100:4001.",{"doi":1451},"10.1182\u002Fblood.V100.12.4001",{"id":24,"text":1453,"url":24,"identifiers":1454},"Neumann, H..  2001. Control of glial immune function by neurons. Glia 36:191.",{"doi":1455},"10.1002\u002Fglia.1108",{"id":24,"text":1457,"url":24,"identifiers":1458},"Bartholomew, A.,  C. Sturgeon,  M. Siatskas,  K. Ferrer,  K. McIntosh,  S. Patil,  S., W. Hardy,  S. Devine,  D. Ucker,  R. Deans, et al 2002. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp. Hematol. 30:42.",{"doi":1459},"10.1016\u002FS0301-472X(01)00769-X",{"id":24,"text":1461,"url":24,"identifiers":1462},"Thomas, J. M.,  F. M. Carver,  P. R. Cunningham,  L. C. Olson,  F. T. Thomas.  1991. Kidney allograft tolerance in primates without chronic immunosuppression: the role of veto cells. Transplantation 51:198.",{"doi":1463},"10.1097\u002F00007890-199101000-00032",{"id":24,"text":1465,"url":24,"identifiers":1466},"Miller, R. G..  1980. An immunological suppressor cell inactivating cytotoxic T-lymphocyte precursor cells recognizing it. Nature 287:544.",{"doi":1467},"10.1038\u002F287544a0",{"id":24,"text":1469,"url":24,"identifiers":1470},"Nakamura, H.,  R. E. Gress.  1990. Interleukin 2 enhancement of veto suppressor cell function in T-cell-depleted bone marrow in vitro and in vivo. Transplantation 49:931.",{"doi":1471},"10.1097\u002F00007890-199005000-00020",{"id":24,"text":1473,"url":24,"identifiers":1474},"Asiedu, C.,  Y. Meng,  W. Wang,  Z Huang,  J. L. Contreras,  J. F. George,  J. M. Thomas.  1999. Immunoregulatory role of CD8α in the veto effect. Transplantation 67:372.",{"doi":1475},"10.1097\u002F00007890-199902150-00006",{"id":24,"text":1477,"url":24,"identifiers":1478},"Haynesworth, S. E.,  M. A. Baber,  A. I. Caplan.  1992. Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone 13:69.",{"doi":1479},"10.1016\u002F8756-3282(92)90363-2",{"id":24,"text":1481,"url":24,"identifiers":1482},"Rameshwar, P.,  A. Poddar,  G. Zhu,  P. Gascon.  1997. Receptor induction regulates the synergistic effects of substance P with IL-1 and PDGF on the proliferation of bone marrow fibroblasts. J. Immunol. 158:3417.",{"doi":1483},"10.4049\u002Fjimmunol.158.7.3417",{"id":24,"text":1485,"url":24,"identifiers":1486},"Majumdar, M. K.,  M. A. Thiede,  J. D. Mosca,  M. Moorman,  S. L. Gerson.  1998. Phenotypic and Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. J. Cell. Physiol. 176:57.",{"doi":1487},"10.1002\u002F(SICI)1097-4652(199807)176:1\u003C57::AID-JCP7>3.0.CO;2-7",{"id":24,"text":1489,"url":24,"identifiers":1490},"Singh, D.,  D. D. Joshi,  M. Hameed,  J. Qian,  P. Gascon,  P. B. Maloof,  A. Mosenthal,  P. Rameshwar.  2000. Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: implications for bone marrow metastasis. Proc. Natl. Acad. Sci. USA 97:388.",{"doi":1491},"10.1073\u002Fpnas.97.1.388",{"id":24,"text":1493,"url":24,"identifiers":1494},"Reyes, M,  T. Lund,  T. Lenvik,  D. Aguiar,  L. Koodie,  C. M. Verfaillie.  2001. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood 98:2615.",{"doi":1495},"10.1182\u002Fblood.V98.9.2615",{"id":24,"text":1497,"url":24,"identifiers":1498},"Conrad, C.,  B. Gottgens,  S. Kinston,  J. Ellwart,  R. Huss.  2002. GATA transcription in a small rhodamine 123lowCD34+ subpopulation of a peripheral blood-derived CD34−CD105+ mesenchymal cell line. Exp. Hematol. 30:887.",{"doi":1499},"10.1016\u002FS0301-472X(02)00865-2",{"id":24,"text":1501,"url":24,"identifiers":1502},"Minguell, J. J.,  A. Erices,  P. Conget.  2001. Mesenchymal stem cells. Exp. Biol. Med. 226:507.",{"doi":1503},"10.1177\u002F153537020122600603",{"id":24,"text":1505,"url":24,"identifiers":1506},"Dennis, J. E.,  P. Charbord.  2002. Origin and differentiation of human and murine stroma. Stem Cells 20:205.",{"doi":1507},"10.1634\u002Fstemcells.20-3-205",{"id":24,"text":1509,"url":24,"identifiers":1510},"Di Nicola, M.,  C. Carlo-Stella,  M. Magni,  M. Milanesi,  P. D. Longoni,  P. Matteucci,  S. Grisanti,  A. M. Gianni.  2002. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99:3838.",{"doi":1511},"10.1182\u002Fblood.V99.10.3838",{"id":24,"text":1513,"url":24,"identifiers":1514},"Noort, W. A.,  A. B. Kruisselbrink,  P. S. Anker,  M. Kruger,  R. L. van Bezooijen,  R. A. de Paus,  M. H. Heemskerk,  C. W. Lowik,  J. H. Falkenburg,  R. Willemze, et al 2002. Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34+ cells in NOD\u002FSCID mice. Exp. Hematol. 30:870.",{"doi":1515},"10.1016\u002FS0301-472X(02)00820-2",{"id":24,"text":1517,"url":24,"identifiers":1518},"Awaya, N.,  K. Rupert,  E. Bryan,  B. Torok-Storb.  2002. Failure of adult marrow-derived stem cells to generate marrow stroma after successful hematopoietic stem cell transplantation. Exp. Hematol. 30:937.",{"doi":1519},"10.1016\u002FS0301-472X(02)00821-4",{"id":24,"text":1521,"url":24,"identifiers":1522},"Haller, G. W.,  B. Lima,  S. M. Kunisaki,  S. Germana,  C. Leguern,  C. A. Huang,  D. H. Sachs.  2002. MHC alloantigens elicit secondary, but not primary, indirect in vitro proliferative responses. J. Immunol. 169:3613.",{"doi":1523},"10.4049\u002Fjimmunol.169.7.3613",{"id":1525,"createTime":1526,"updateTime":1527,"relativeEntities":1528,"slug":1529,"properties":1530,"entityType":295,"verifyStatus":296,"verifyTime":1545,"verifyNote":297,"languages":1546,"translateLanguages":24,"viewCount":25,"primaryUrl":1547,"fullTextUrl":24,"authors":1548,"publicationType":423,"publisherRelationship":1647,"citationCount":1701,"citationInfo":1702,"publishDate":1705,"publishYear":1703,"citationAnalyzeStatus":23,"lastCitationAnalyze":1706,"indexDatabases":1707,"openAccess":24,"references":1708,"isForceReanalyzing":615},"79ce4775-e3b6-4886-815c-0d076fc67aca","2024-09-02T11:40:00.146+00:00","2026-07-22T21:51:44.249+00:00",[],"Deregulated-Bcl-2-gene-expression-selectively-prolongs-survival-of-growth-factor-deprived-hemopoietic-cell-lines-",{"mag":1531,"gsPaper":1533,"openalex":1535,"abstract":1537,"title":1539,"pm":1541,"doi":1543},{"VOID":1532},"1554380543",{"VOID":1534},"[\"13945499406794198649\"]",{"VOID":1536},"W1554380543",{"EN":1538},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:p>The t(14;18) of human follicular B cell lymphoma translocates the Bcl-2 gene into the Ig H chain locus and markedly deregulates Bcl-2 expression. We sought to determine if Bcl-2 could be directly implicated in a growth-factor pathway. Consequently, we introduced a retrovirus containing the murine Bcl-2 gene (N2-M-Bcl-2) or the parental retrovirus (N2) into a series of factor-dependent hemopoietic cell lines. Overexpressed Bcl-2 resulted in no long term IL-2, IL-3, or IL-6 independent clones, indicating that Bcl-2 could not spare the need for a specific ligand-receptor interaction. However, Bcl-2 did extend the short term survival of IL-3-dependent cell lines after factor deprivation. Although viable, IL-3-deprived pro B lymphocytes (FL5.12) bearing N2-M-Bcl-2 were in Go, and deregulated Bcl-2 did not obviously influence cell-cycle progression. Bcl-2 predominant effects were to delay the onset of cell death and to modestly augment viable cell growth in the first 48 h after IL-3 deprivation. This death sparing was associated with increased levels of Bcl-2 RNA and protein in factor-deprived cells possessing N2-M-Bcl-2. This result was not restricted to prolymphocytes because an IL-3-dependent mast cell line (32D) as well as a promyeloid line (FDC-P1) demonstrated the same response to Bcl-2. Moreover, the effect was not limited to the IL-3\u002FIL-3R signal transduction pathway in that promyeloid cells maintained in granulocyte-macrophage-CSF or IL-4 displayed a similar response. Yet, Bcl-2-enhanced cell survival was not universal as an IL-2-dependent T cell line, and an IL-6-dependent myeloma line demonstrated no consistent effect upon IL withdrawal. Thus, Bcl-2 appears to interfere with cell death but in a cell type and\u002For factor-restricted fashion.\u003C\u002Fjats:p>",{"EN":1540},"Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.",{"VOID":1542},"2184193",{"VOID":1544},"10.4049\u002Fjimmunol.144.9.3602","2024-09-02T11:40:00.145+00:00",[299],"https:\u002F\u002Fjournals.aai.org\u002Fjimmunol\u002Farticle\u002F144\u002F9\u002F3602\u002F110574\u002FDeregulated-Bcl-2-gene-expression-selectively",[1549,1568,1585,1600,1617,1632],{"id":1550,"sortIndex":25,"researcher":24,"roles":1551,"affiliations":1552,"properties":1561,"displayName":1565,"givenName":24,"familyName":24},"82ecb859-c1e2-40d2-910e-3ff06452eb0b",[],[1553],{"id":1554,"sortIndex":25,"affiliation":1555,"properties":24},"076d90e0-1e37-4c48-8d4a-9436c0769944",{"id":1554,"createTime":24,"updateTime":24,"relativeEntities":1556,"slug":24,"properties":1557,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1560,"statistic":24},[],{"title":1558},{"EN":1559},"Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110.",[],{"orcid":1562,"title":1564,"openalex":1566},{"VOID":1563},"https:\u002F\u002Forcid.org\u002F0000-0002-6529-2695",{"EN":1565},"Gabriel Núñez",{"VOID":1567},"A5040117830",{"id":1569,"sortIndex":110,"researcher":24,"roles":1570,"affiliations":1571,"properties":1578,"displayName":1582,"givenName":24,"familyName":24},"06505476-42e2-43dd-82fe-bca4ee4220f4",[],[1572],{"id":1554,"sortIndex":25,"affiliation":1573,"properties":24},{"id":1554,"createTime":24,"updateTime":24,"relativeEntities":1574,"slug":24,"properties":1575,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1577,"statistic":24},[],{"title":1576},{"EN":1559},[],{"orcid":1579,"title":1581,"openalex":1583},{"VOID":1580},"https:\u002F\u002Forcid.org\u002F0000-0003-1297-2758",{"EN":1582},"Leslie London",{"VOID":1584},"A5047948007",{"id":1586,"sortIndex":109,"researcher":24,"roles":1587,"affiliations":1588,"properties":1595,"displayName":1597,"givenName":24,"familyName":24},"1e9ef9a0-7c4c-4cee-96af-71623bdc3f37",[],[1589],{"id":1554,"sortIndex":25,"affiliation":1590,"properties":24},{"id":1554,"createTime":24,"updateTime":24,"relativeEntities":1591,"slug":24,"properties":1592,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1594,"statistic":24},[],{"title":1593},{"EN":1559},[],{"title":1596,"openalex":1598},{"EN":1597},"David M. Hockenbery",{"VOID":1599},"A5016626619",{"id":1601,"sortIndex":111,"researcher":24,"roles":1602,"affiliations":1603,"properties":1610,"displayName":1614,"givenName":24,"familyName":24},"1e96cb05-38cc-47ff-86e2-3f772ae4a565",[],[1604],{"id":1554,"sortIndex":25,"affiliation":1605,"properties":24},{"id":1554,"createTime":24,"updateTime":24,"relativeEntities":1606,"slug":24,"properties":1607,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1609,"statistic":24},[],{"title":1608},{"EN":1559},[],{"orcid":1611,"title":1613,"openalex":1615},{"VOID":1612},"https:\u002F\u002Forcid.org\u002F0000-0003-3455-0716",{"EN":1614},"Martha A. Alexander‐Miller",{"VOID":1616},"A5003621059",{"id":1618,"sortIndex":112,"researcher":24,"roles":1619,"affiliations":1620,"properties":1627,"displayName":1629,"givenName":24,"familyName":24},"da8e2af0-6bed-4876-bbc3-5867ef842956",[],[1621],{"id":1554,"sortIndex":25,"affiliation":1622,"properties":24},{"id":1554,"createTime":24,"updateTime":24,"relativeEntities":1623,"slug":24,"properties":1624,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1626,"statistic":24},[],{"title":1625},{"EN":1559},[],{"title":1628,"openalex":1630},{"EN":1629},"John P. McKearn",{"VOID":1631},"A5082726494",{"id":1633,"sortIndex":113,"researcher":24,"roles":1634,"affiliations":1635,"properties":1642,"displayName":1644,"givenName":24,"familyName":24},"b74c9c39-47c9-4e77-9202-3c84db1f8dd5",[],[1636],{"id":1554,"sortIndex":25,"affiliation":1637,"properties":24},{"id":1554,"createTime":24,"updateTime":24,"relativeEntities":1638,"slug":24,"properties":1639,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1641,"statistic":24},[],{"title":1640},{"EN":1559},[],{"title":1643,"openalex":1645},{"EN":1644},"S J Korsmeyer",{"VOID":1646},"A5075887932",{"url":24,"publisher":1648,"properties":1695},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1649,"slug":10,"properties":1650,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1655,"manageAffiliations":1664,"indexDatabases":1675,"url":90,"thumbnailPath":24,"statistic":1690,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1651,"eissn":1652,"issn":1653,"title":1654},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[1656,1660],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":1657,"label":1658,"description":1659,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":1661,"label":1662,"description":1663,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[1665,1670],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":1666,"slug":24,"properties":1667,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1669,"statistic":24},[],{"title":1668},{"EN":45},[],{"id":48,"createTime":24,"updateTime":24,"relativeEntities":1671,"slug":24,"properties":1672,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1674,"statistic":24},[],{"title":1673},{"EN":52},[],[1676,1683],{"id":56,"indexDatabase":1677,"url":69,"indexYears":24,"academicFieldIds":1682,"indexDatabaseRanking":24},{"id":58,"createTime":24,"updateTime":24,"relativeEntities":1678,"label":1679,"description":1680,"key":65,"publicationTags":1681,"standard":24},[],{"EN":61,"VI":61},{"EN":63,"VI":64},[67,68],[71],{"id":73,"indexDatabase":1684,"url":84,"indexYears":85,"academicFieldIds":1689,"indexDatabaseRanking":89},{"id":75,"createTime":24,"updateTime":24,"relativeEntities":1685,"label":1686,"description":1687,"key":81,"publicationTags":1688,"standard":24},[],{"EN":78,"VI":78},{"EN":78,"VI":80},[83],[87,88],{"impactFactor":25,"impactFactorByYear":1691,"i10Index":105,"i10IndexLast5Year":106,"totalPublication":107,"totalPublicationByYear":1692,"totalCitation":145,"totalCitationByYear":1693,"totalCitationPerPublication":210,"totalCitationPerPublicationByYear":1694,"hindexLast5Year":208,"hindex":208},{"2012":93,"2013":94,"2014":95,"2015":96,"2016":97,"2017":98,"2018":99,"2019":100,"2020":101,"2021":102,"2022":103,"2023":104},{"1938":109,"1940":110,"1946":109,"1954":110,"1956":109,"1958":110,"1959":110,"1963":110,"1965":111,"1966":112,"1967":110,"1968":112,"1969":112,"1970":111,"1971":112,"1972":113,"1973":112,"1974":111,"1975":114,"1976":115,"1977":116,"1978":115,"1979":106,"1980":117,"1981":114,"1982":115,"1983":118,"1984":106,"1985":119,"1986":120,"1987":118,"1988":121,"1989":117,"1990":122,"1991":123,"1992":124,"1993":125,"1994":126,"1995":127,"1996":128,"1997":129,"1998":130,"1999":131,"2000":132,"2001":133,"2002":134,"2003":135,"2004":135,"2005":136,"2006":137,"2007":138,"2008":139,"2009":128,"2010":140,"2011":141,"2012":128,"2013":142,"2014":121,"2015":119,"2016":120,"2017":102,"2018":143,"2020":102,"2021":144,"2022":110},{"1938":147,"1940":148,"1946":124,"1954":149,"1956":150,"1958":151,"1959":152,"1963":153,"1965":154,"1966":155,"1967":156,"1968":157,"1969":158,"1970":159,"1971":160,"1972":161,"1973":162,"1974":163,"1975":164,"1976":165,"1977":166,"1978":167,"1979":168,"1980":169,"1981":170,"1982":171,"1983":172,"1984":173,"1985":174,"1986":175,"1987":176,"1988":177,"1989":178,"1990":179,"1991":180,"1992":181,"1993":182,"1994":183,"1995":184,"1996":185,"1997":186,"1998":187,"1999":188,"2000":189,"2001":190,"2002":191,"2003":192,"2004":193,"2005":194,"2006":195,"2007":196,"2008":197,"2009":198,"2010":199,"2011":200,"2012":201,"2013":202,"2014":203,"2015":204,"2016":205,"2017":206,"2018":207,"2020":208,"2021":209,"2022":109},{"1938":212,"1940":148,"1946":213,"1954":149,"1956":214,"1958":151,"1959":152,"1963":153,"1965":215,"1966":216,"1967":156,"1968":217,"1969":218,"1970":219,"1971":220,"1972":221,"1973":222,"1974":223,"1975":224,"1976":225,"1977":226,"1978":227,"1979":228,"1980":229,"1981":230,"1982":231,"1983":232,"1984":233,"1985":234,"1986":235,"1987":236,"1988":237,"1989":238,"1990":239,"1991":240,"1992":241,"1993":242,"1994":243,"1995":244,"1996":245,"1997":246,"1998":247,"1999":248,"2000":249,"2001":250,"2002":251,"2003":252,"2004":253,"2005":254,"2006":255,"2007":256,"2008":257,"2009":258,"2010":259,"2011":260,"2012":261,"2013":262,"2014":263,"2015":264,"2016":265,"2017":266,"2018":267,"2020":268,"2021":269,"2022":109},{"issue":1696,"pages":1697,"volume":1699},{"VOID":474},{"VOID":1698},"3602-3610",{"VOID":1700},"144",925,{"total":1701,"publishYear":1703,"statisticByYear":1704},1990,{"2012":112,"2013":143,"2014":112,"2015":111,"2016":113,"2017":111,"2018":112,"2019":111,"2020":113,"2021":109,"2022":143,"2023":110},"1990-05-01","2026-07-22T21:51:44.248+00:00",[67,89],[],{"id":1710,"createTime":1711,"updateTime":1712,"relativeEntities":1713,"slug":1714,"properties":1715,"entityType":295,"verifyStatus":296,"verifyTime":1730,"verifyNote":297,"languages":1731,"translateLanguages":24,"viewCount":25,"primaryUrl":1732,"fullTextUrl":24,"authors":1733,"publicationType":423,"publisherRelationship":1796,"citationCount":223,"citationInfo":1851,"publishDate":1854,"publishYear":1852,"citationAnalyzeStatus":1855,"lastCitationAnalyze":1856,"indexDatabases":1857,"openAccess":24,"references":1858,"isForceReanalyzing":615},"bce67461-5b17-4a86-815d-00bd96d19898","2024-10-09T01:48:41.777+00:00","2026-07-22T14:18:17.380+00:00",[],"Antitumoral-properties-of-aged-human-monocytes-",{"mag":1716,"gsPaper":1718,"openalex":1720,"abstract":1722,"title":1724,"pm":1726,"doi":1728},{"VOID":1717},"1845012539",{"VOID":1719},"[]",{"VOID":1721},"W1845012539",{"EN":1723},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:p>It is known that older people are more sensitive to cancer and infectious agents and need more time to recover from such disorders. Can this difference in sensitivity to cancer and infections between elderly and younger people be a result of a difference in their immune systems and, more specifically, in the way monocytes react to infectious agents and cancer cells? To determine what happens after cells have aged, human monocytes were purified from young donors (approximately 25 years of age) and from older donors (65 years of age or older) and tested for their ability to respond to the polyclonal activator LPS. Our results showed that monocytes from aged donors (aged monocytes), when compared with monocytes from younger donors (young monocytes) did lose part of their cytotoxicity against tumor cells (A375 human melanoma cells and L929 murine fibroblast cells). In addition, aged monocytes displayed a sharp decrease in IL-1 secretion, but did display the intracellular 31 kDa IL-1 precursor. Moreover, aged monocytes displayed a decrease in the production of reactive oxygen intermediates such as NO2 and H2O2. Finally, aged monocytes stimulated by LPS displayed an increase in intracellular cyclic AMP and have lost their protein kinase C translocation from the cytosol to the plasma membranes. These results suggest that age affects the immunologic and antitumoral properties of human monocytes.\u003C\u002Fjats:p>",{"EN":1725},"Antitumoral properties of aged human monocytes.",{"VOID":1727},"7814887",{"VOID":1729},"10.4049\u002Fjimmunol.154.2.832","2024-10-09T01:48:41.776+00:00",[299],"https:\u002F\u002Fjournals.aai.org\u002Fjimmunol\u002Farticle\u002F154\u002F2\u002F832\u002F27849\u002FAntitumoral-properties-of-aged-human-monocytes",[1734,1751,1766,1781],{"id":1735,"sortIndex":25,"researcher":24,"roles":1736,"affiliations":1737,"properties":1746,"displayName":1748,"givenName":24,"familyName":24},"16767848-fddf-47e2-b5c6-81617b8dca56",[],[1738],{"id":1739,"sortIndex":25,"affiliation":1740,"properties":24},"4d706aea-5dab-4f53-b0ac-17c5625579ed",{"id":1739,"createTime":24,"updateTime":24,"relativeEntities":1741,"slug":24,"properties":1742,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1745,"statistic":24},[],{"title":1743},{"EN":1744},"Department of Pharmacology, Northwestern University Medical School, Chicago, IL 60611.",[],{"title":1747,"openalex":1749},{"EN":1748},"Julie A. McLachlan",{"VOID":1750},"A5011094269",{"id":1752,"sortIndex":110,"researcher":24,"roles":1753,"affiliations":1754,"properties":1761,"displayName":1763,"givenName":24,"familyName":24},"4e10e193-9658-4989-aac7-746ef4e56111",[],[1755],{"id":1739,"sortIndex":25,"affiliation":1756,"properties":24},{"id":1739,"createTime":24,"updateTime":24,"relativeEntities":1757,"slug":24,"properties":1758,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1760,"statistic":24},[],{"title":1759},{"EN":1744},[],{"title":1762,"openalex":1764},{"EN":1763},"Carlo D. Serkin",{"VOID":1765},"A5020085548",{"id":1767,"sortIndex":109,"researcher":24,"roles":1768,"affiliations":1769,"properties":1776,"displayName":1778,"givenName":24,"familyName":24},"287abe29-ba13-4c3d-a111-940507c30954",[],[1770],{"id":1739,"sortIndex":25,"affiliation":1771,"properties":24},{"id":1739,"createTime":24,"updateTime":24,"relativeEntities":1772,"slug":24,"properties":1773,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1775,"statistic":24},[],{"title":1774},{"EN":1744},[],{"title":1777,"openalex":1779},{"EN":1778},"K M Morrey",{"VOID":1780},"A5066163367",{"id":1782,"sortIndex":111,"researcher":24,"roles":1783,"affiliations":1784,"properties":1791,"displayName":1793,"givenName":24,"familyName":24},"f633e180-ceee-44d5-b454-8914c0746d1c",[],[1785],{"id":1739,"sortIndex":25,"affiliation":1786,"properties":24},{"id":1739,"createTime":24,"updateTime":24,"relativeEntities":1787,"slug":24,"properties":1788,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1790,"statistic":24},[],{"title":1789},{"EN":1744},[],{"title":1792,"openalex":1794},{"EN":1793},"O Bakouche",{"VOID":1795},"A5060248868",{"url":24,"publisher":1797,"properties":1844},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1798,"slug":10,"properties":1799,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1804,"manageAffiliations":1813,"indexDatabases":1824,"url":90,"thumbnailPath":24,"statistic":1839,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1800,"eissn":1801,"issn":1802,"title":1803},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[1805,1809],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":1806,"label":1807,"description":1808,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":1810,"label":1811,"description":1812,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[1814,1819],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":1815,"slug":24,"properties":1816,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1818,"statistic":24},[],{"title":1817},{"EN":45},[],{"id":48,"createTime":24,"updateTime":24,"relativeEntities":1820,"slug":24,"properties":1821,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1823,"statistic":24},[],{"title":1822},{"EN":52},[],[1825,1832],{"id":56,"indexDatabase":1826,"url":69,"indexYears":24,"academicFieldIds":1831,"indexDatabaseRanking":24},{"id":58,"createTime":24,"updateTime":24,"relativeEntities":1827,"label":1828,"description":1829,"key":65,"publicationTags":1830,"standard":24},[],{"EN":61,"VI":61},{"EN":63,"VI":64},[67,68],[71],{"id":73,"indexDatabase":1833,"url":84,"indexYears":85,"academicFieldIds":1838,"indexDatabaseRanking":89},{"id":75,"createTime":24,"updateTime":24,"relativeEntities":1834,"label":1835,"description":1836,"key":81,"publicationTags":1837,"standard":24},[],{"EN":78,"VI":78},{"EN":78,"VI":80},[83],[87,88],{"impactFactor":25,"impactFactorByYear":1840,"i10Index":105,"i10IndexLast5Year":106,"totalPublication":107,"totalPublicationByYear":1841,"totalCitation":145,"totalCitationByYear":1842,"totalCitationPerPublication":210,"totalCitationPerPublicationByYear":1843,"hindexLast5Year":208,"hindex":208},{"2012":93,"2013":94,"2014":95,"2015":96,"2016":97,"2017":98,"2018":99,"2019":100,"2020":101,"2021":102,"2022":103,"2023":104},{"1938":109,"1940":110,"1946":109,"1954":110,"1956":109,"1958":110,"1959":110,"1963":110,"1965":111,"1966":112,"1967":110,"1968":112,"1969":112,"1970":111,"1971":112,"1972":113,"1973":112,"1974":111,"1975":114,"1976":115,"1977":116,"1978":115,"1979":106,"1980":117,"1981":114,"1982":115,"1983":118,"1984":106,"1985":119,"1986":120,"1987":118,"1988":121,"1989":117,"1990":122,"1991":123,"1992":124,"1993":125,"1994":126,"1995":127,"1996":128,"1997":129,"1998":130,"1999":131,"2000":132,"2001":133,"2002":134,"2003":135,"2004":135,"2005":136,"2006":137,"2007":138,"2008":139,"2009":128,"2010":140,"2011":141,"2012":128,"2013":142,"2014":121,"2015":119,"2016":120,"2017":102,"2018":143,"2020":102,"2021":144,"2022":110},{"1938":147,"1940":148,"1946":124,"1954":149,"1956":150,"1958":151,"1959":152,"1963":153,"1965":154,"1966":155,"1967":156,"1968":157,"1969":158,"1970":159,"1971":160,"1972":161,"1973":162,"1974":163,"1975":164,"1976":165,"1977":166,"1978":167,"1979":168,"1980":169,"1981":170,"1982":171,"1983":172,"1984":173,"1985":174,"1986":175,"1987":176,"1988":177,"1989":178,"1990":179,"1991":180,"1992":181,"1993":182,"1994":183,"1995":184,"1996":185,"1997":186,"1998":187,"1999":188,"2000":189,"2001":190,"2002":191,"2003":192,"2004":193,"2005":194,"2006":195,"2007":196,"2008":197,"2009":198,"2010":199,"2011":200,"2012":201,"2013":202,"2014":203,"2015":204,"2016":205,"2017":206,"2018":207,"2020":208,"2021":209,"2022":109},{"1938":212,"1940":148,"1946":213,"1954":149,"1956":214,"1958":151,"1959":152,"1963":153,"1965":215,"1966":216,"1967":156,"1968":217,"1969":218,"1970":219,"1971":220,"1972":221,"1973":222,"1974":223,"1975":224,"1976":225,"1977":226,"1978":227,"1979":228,"1980":229,"1981":230,"1982":231,"1983":232,"1984":233,"1985":234,"1986":235,"1987":236,"1988":237,"1989":238,"1990":239,"1991":240,"1992":241,"1993":242,"1994":243,"1995":244,"1996":245,"1997":246,"1998":247,"1999":248,"2000":249,"2001":250,"2002":251,"2003":252,"2004":253,"2005":254,"2006":255,"2007":256,"2008":257,"2009":258,"2010":259,"2011":260,"2012":261,"2013":262,"2014":263,"2015":264,"2016":265,"2017":266,"2018":267,"2020":268,"2021":269,"2022":109},{"issue":1845,"pages":1847,"volume":1849},{"VOID":1846},"2",{"VOID":1848},"832-843",{"VOID":1850},"154",{"total":223,"publishYear":1852,"statisticByYear":1853},1995,{"2012":110,"2013":109,"2014":111,"2015":112,"2016":112,"2017":109,"2018":110,"2019":111,"2020":112,"2021":112,"2022":110,"2023":109},"1995-01-15","ERROR_IN_GET_PLATFORM_ID","2026-07-22T14:18:17.378+00:00",[67,89],[],{"id":1860,"createTime":1861,"updateTime":1862,"relativeEntities":1863,"slug":1864,"properties":1865,"entityType":295,"verifyStatus":296,"verifyTime":1882,"verifyNote":297,"languages":1883,"translateLanguages":24,"viewCount":25,"primaryUrl":1884,"fullTextUrl":24,"authors":1885,"publicationType":423,"publisherRelationship":1937,"citationCount":25,"citationInfo":1991,"publishDate":1994,"publishYear":1992,"citationAnalyzeStatus":23,"lastCitationAnalyze":1995,"indexDatabases":1996,"openAccess":24,"references":1997,"isForceReanalyzing":615},"5d9e7648-b201-4ddc-80c1-730470c35bac","2024-10-01T05:30:48.766+00:00","2026-07-22T10:04:35.178+00:00",[],"Combined-IL-15-IL-15R%CE%B1-Immunotherapy-Maximizes-IL-15-Activity-In-Vivo",{"mag":1866,"gsPaper":1868,"pmc":1870,"openalex":1872,"abstract":1874,"title":1876,"pm":1878,"doi":1880},{"VOID":1867},"2119312822",{"VOID":1869},"[\"12362202522899922703\"]",{"VOID":1871},"2847275",{"VOID":1873},"W2119312822",{"EN":1875},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>IL-15 has substantial potential as an immunotherapeutic agent for augmenting immune responses. However, the activity of IL-15 is mediated by a unique mechanism in which the cytokine is transpresented by cell-bound high-affinity IL-15Rα to target cells expressing the IL-15Rβ and the common γ-chain. Thus, the efficacy of administered IL-15 alone may be limited by the availability of free IL-15Rα. We now show that administration of soluble IL-15\u002FIL-15Rα complexes greatly enhanced IL-15 half-life and bioavailability in vivo. Treatment of mice with this complex, but not with IL-15 alone, resulted in robust proliferation of memory CD8 T cells, NK cells, and NK T cells. The activity of the complex required IL-15Rβ, but not IL-15Rα, expression by the responding cells and was IL-7-independent. Interestingly, IL-15\u002FIL-15Rα immunotherapy also caused naive CD8 T cell activation and development into effector cells and long-term memory T cells. Lastly, complexed IL-15, as compared with IL-15 alone, dramatically reduced tumor burden in a model of B16 melanoma. These findings hold significant importance for the use of IL-15 as a potential adjuvant\u002Ftherapeutic and inducer of homeostatic proliferation, without the necessity for prior immunodepletion.\u003C\u002Fjats:p>",{"EN":1877},"Combined IL-15\u002FIL-15Rα Immunotherapy Maximizes IL-15 Activity In Vivo",{"VOID":1879},"17056533",{"VOID":1881},"10.4049\u002Fjimmunol.177.9.6072","2024-10-01T05:30:48.765+00:00",[299],"https:\u002F\u002Fjournals.aai.org\u002Fjimmunol\u002Farticle\u002F177\u002F9\u002F6072\u002F1621\u002FCombined-IL-15-IL-15R-Immunotherapy-Maximizes-IL",[1886,1903,1922],{"id":1887,"sortIndex":25,"researcher":24,"roles":1888,"affiliations":1889,"properties":1898,"displayName":1900,"givenName":24,"familyName":24},"ded4bc3c-14c0-44c1-b82d-45e5bdf005f2",[],[1890],{"id":1891,"sortIndex":25,"affiliation":1892,"properties":24},"13aecda3-86d8-4089-b92b-ed8f50284e71",{"id":1891,"createTime":24,"updateTime":24,"relativeEntities":1893,"slug":24,"properties":1894,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1897,"statistic":24},[],{"title":1895},{"EN":1896},"Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.",[],{"title":1899,"openalex":1901},{"EN":1900},"Thomas A. Stoklasek",{"VOID":1902},"A5090725512",{"id":1904,"sortIndex":110,"researcher":24,"roles":1905,"affiliations":1906,"properties":1915,"displayName":1919,"givenName":24,"familyName":24},"19b10cbe-f7eb-48eb-a327-6714ddc8c82b",[],[1907],{"id":1908,"sortIndex":25,"affiliation":1909,"properties":24},"ef022d69-12d4-473c-b83d-1bce334cd0c8",{"id":1908,"createTime":24,"updateTime":24,"relativeEntities":1910,"slug":24,"properties":1911,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1914,"statistic":24},[],{"title":1912},{"EN":1913},"#Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030",[],{"orcid":1916,"title":1918,"openalex":1920},{"VOID":1917},"https:\u002F\u002Forcid.org\u002F0000-0002-3738-2853",{"EN":1919},"Kimberly S. Schluns",{"VOID":1921},"A5078671269",{"id":1923,"sortIndex":109,"researcher":24,"roles":1924,"affiliations":1925,"properties":1932,"displayName":1934,"givenName":24,"familyName":24},"62792294-a2b3-4438-b700-cccb85c4e8e9",[],[1926],{"id":1908,"sortIndex":25,"affiliation":1927,"properties":24},{"id":1908,"createTime":24,"updateTime":24,"relativeEntities":1928,"slug":24,"properties":1929,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1931,"statistic":24},[],{"title":1930},{"EN":1913},[],{"title":1933,"openalex":1935},{"EN":1934},"Leo Lefrançois",{"VOID":1936},"A5039675439",{"url":24,"publisher":1938,"properties":1985},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1939,"slug":10,"properties":1940,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1945,"manageAffiliations":1954,"indexDatabases":1965,"url":90,"thumbnailPath":24,"statistic":1980,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1941,"eissn":1942,"issn":1943,"title":1944},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[1946,1950],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":1947,"label":1948,"description":1949,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":1951,"label":1952,"description":1953,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[1955,1960],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":1956,"slug":24,"properties":1957,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1959,"statistic":24},[],{"title":1958},{"EN":45},[],{"id":48,"createTime":24,"updateTime":24,"relativeEntities":1961,"slug":24,"properties":1962,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1964,"statistic":24},[],{"title":1963},{"EN":52},[],[1966,1973],{"id":56,"indexDatabase":1967,"url":69,"indexYears":24,"academicFieldIds":1972,"indexDatabaseRanking":24},{"id":58,"createTime":24,"updateTime":24,"relativeEntities":1968,"label":1969,"description":1970,"key":65,"publicationTags":1971,"standard":24},[],{"EN":61,"VI":61},{"EN":63,"VI":64},[67,68],[71],{"id":73,"indexDatabase":1974,"url":84,"indexYears":85,"academicFieldIds":1979,"indexDatabaseRanking":89},{"id":75,"createTime":24,"updateTime":24,"relativeEntities":1975,"label":1976,"description":1977,"key":81,"publicationTags":1978,"standard":24},[],{"EN":78,"VI":78},{"EN":78,"VI":80},[83],[87,88],{"impactFactor":25,"impactFactorByYear":1981,"i10Index":105,"i10IndexLast5Year":106,"totalPublication":107,"totalPublicationByYear":1982,"totalCitation":145,"totalCitationByYear":1983,"totalCitationPerPublication":210,"totalCitationPerPublicationByYear":1984,"hindexLast5Year":208,"hindex":208},{"2012":93,"2013":94,"2014":95,"2015":96,"2016":97,"2017":98,"2018":99,"2019":100,"2020":101,"2021":102,"2022":103,"2023":104},{"1938":109,"1940":110,"1946":109,"1954":110,"1956":109,"1958":110,"1959":110,"1963":110,"1965":111,"1966":112,"1967":110,"1968":112,"1969":112,"1970":111,"1971":112,"1972":113,"1973":112,"1974":111,"1975":114,"1976":115,"1977":116,"1978":115,"1979":106,"1980":117,"1981":114,"1982":115,"1983":118,"1984":106,"1985":119,"1986":120,"1987":118,"1988":121,"1989":117,"1990":122,"1991":123,"1992":124,"1993":125,"1994":126,"1995":127,"1996":128,"1997":129,"1998":130,"1999":131,"2000":132,"2001":133,"2002":134,"2003":135,"2004":135,"2005":136,"2006":137,"2007":138,"2008":139,"2009":128,"2010":140,"2011":141,"2012":128,"2013":142,"2014":121,"2015":119,"2016":120,"2017":102,"2018":143,"2020":102,"2021":144,"2022":110},{"1938":147,"1940":148,"1946":124,"1954":149,"1956":150,"1958":151,"1959":152,"1963":153,"1965":154,"1966":155,"1967":156,"1968":157,"1969":158,"1970":159,"1971":160,"1972":161,"1973":162,"1974":163,"1975":164,"1976":165,"1977":166,"1978":167,"1979":168,"1980":169,"1981":170,"1982":171,"1983":172,"1984":173,"1985":174,"1986":175,"1987":176,"1988":177,"1989":178,"1990":179,"1991":180,"1992":181,"1993":182,"1994":183,"1995":184,"1996":185,"1997":186,"1998":187,"1999":188,"2000":189,"2001":190,"2002":191,"2003":192,"2004":193,"2005":194,"2006":195,"2007":196,"2008":197,"2009":198,"2010":199,"2011":200,"2012":201,"2013":202,"2014":203,"2015":204,"2016":205,"2017":206,"2018":207,"2020":208,"2021":209,"2022":109},{"1938":212,"1940":148,"1946":213,"1954":149,"1956":214,"1958":151,"1959":152,"1963":153,"1965":215,"1966":216,"1967":156,"1968":217,"1969":218,"1970":219,"1971":220,"1972":221,"1973":222,"1974":223,"1975":224,"1976":225,"1977":226,"1978":227,"1979":228,"1980":229,"1981":230,"1982":231,"1983":232,"1984":233,"1985":234,"1986":235,"1987":236,"1988":237,"1989":238,"1990":239,"1991":240,"1992":241,"1993":242,"1994":243,"1995":244,"1996":245,"1997":246,"1998":247,"1999":248,"2000":249,"2001":250,"2002":251,"2003":252,"2004":253,"2005":254,"2006":255,"2007":256,"2008":257,"2009":258,"2010":259,"2011":260,"2012":261,"2013":262,"2014":263,"2015":264,"2016":265,"2017":266,"2018":267,"2020":268,"2021":269,"2022":109},{"issue":1986,"pages":1987,"volume":1989},{"VOID":474},{"VOID":1988},"6072-6080",{"VOID":1990},"177",{"total":25,"publishYear":1992,"statisticByYear":1993},2006,{},"2006-11-01","2026-07-22T10:04:35.177+00:00",[67,89],[1998,2002,2006,2010,2014,2018,2022,2026,2030,2034,2038,2042,2046,2050,2054,2058,2062,2066,2070,2074,2078,2082,2086,2090,2094,2098,2102,2106,2110,2114,2118,2122,2126,2130,2134,2138,2142,2146,2150,2154,2157,2161,2165,2169,2173,2177,2181,2185,2189,2193,2197,2201,2205,2209,2212,2216,2220,2224,2228,2232,2236,2240,2244,2248,2252,2256,2260,2264,2268,2272,2276,2280,2284,2288,2292,2296,2300,2304,2308,2312,2316,2320],{"id":24,"text":1999,"url":24,"identifiers":2000},"Grabstein, K. H., J. Eisenman, K. Shanebeck, C. Rauch, S. Srinivasan, V. Fung, C. Beers, J. Richardson, M. A. Schoenborn, M. Ahdieh. 1994. Cloning of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor. Science 264: 965-968.",{"doi":2001},"10.1126\u002Fscience.8178155",{"id":24,"text":2003,"url":24,"identifiers":2004},"Bamford, R. N., A. J. Grant, J. D. Burton, C. Peters, G. Kurys, C. K. Goldman, J. Brennan, E. Roessler, T. A. Waldmann. 1994. The interleukin (IL)-2 receptor-β chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer-cells. Proc. Natl. Acad. Sci. USA 91: 4940-4944.",{"doi":2005},"10.1073\u002Fpnas.91.11.4940",{"id":24,"text":2007,"url":24,"identifiers":2008},"Bamford, R. N., A. P. Battiata, J. D. Burton, H. Sharma, T. A. Waldmann. 1996. Interleukin (IL) 15\u002FIL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region \u002FIL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation. Proc. Natl. Acad. Sci. USA 93: 2897-2902.",{"doi":2009},"10.1073\u002Fpnas.93.7.2897",{"id":24,"text":2011,"url":24,"identifiers":2012},"Nishimura, H., A. Fujimoto, N. Tamura, T. Yajima, W. Wajjwalku, Y. Yoshikai. 2005. A novel autoregulatory mechanism for transcriptional activation of the IL-15 gene by a nonsecretable isoform of IL-15 generated by alternative splicing. FASEB J. 19: 19-28.",{"doi":2013},"10.1096\u002Ffj.04-2633com",{"id":24,"text":2015,"url":24,"identifiers":2016},"Villinger, F., R. Miller, K. Mori, A. E. Mayne, P. Bostik, J. B. Sundstrom, C. Sugimoto, A. A. Ansari. 2004. IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus macaques. Vaccine 22: 3510-3521.",{"doi":2017},"10.1016\u002Fj.vaccine.2003.07.022",{"id":24,"text":2019,"url":24,"identifiers":2020},"Burton, J. D., R. N. Bamford, C. Peters, A. J. Grant, G. Kurys, C. K. Goldman, J. Brennan, E. Roessler, T. A. Waldmann. 1994. A lymphokine, provisionally designated interleukin-T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer-cells. Proc. Natl. Acad. Sci. USA 91: 4935-4939.",{"doi":2021},"10.1073\u002Fpnas.91.11.4935",{"id":24,"text":2023,"url":24,"identifiers":2024},"Kennedy, M. K., M. Glaccum, S. N. Brown, E. A. Butz, J. L. Viney, M. Embers, N. Matsuki, K. Charrier, L. Sedger, C. R. Willis, et al 2000. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin-15-deficient mice. J. Exp. Med. 191: 771-780.",{"doi":2025},"10.1084\u002Fjem.191.5.771",{"id":24,"text":2027,"url":24,"identifiers":2028},"Lodolce, J. P., D. L. Boone, S. Chai, R. E. Swain, T. Dassopoulos, S. Trettin, A. Ma. 1998. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9: 669-676.",{"doi":2029},"10.1016\u002FS1074-7613(00)80664-0",{"id":24,"text":2031,"url":24,"identifiers":2032},"Schluns, K. S., K. Williams, A. Ma, X. X. Zheng, L. Lefrançois. 2002. Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J. Immunol. 168: 4827-4831.",{"doi":2033},"10.4049\u002Fjimmunol.168.10.4827",{"id":24,"text":2035,"url":24,"identifiers":2036},"Becker, T. C., E. J. Wherry, D. Boone, K. Murali-Krishna, R. Antia, A. Ma, R. Ahmed. 2002. Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells. J. Exp. Med. 195: 1541-1548.",{"doi":2037},"10.1084\u002Fjem.20020369",{"id":24,"text":2039,"url":24,"identifiers":2040},"Goldrath, A. W., P. V. Sivakumar, M. Glaccum, M. K. Kennedy, M. J. Bevan, C. Benoist, D. Mathis, E. A. Butz. 2002. Cytokine requirements for acute and basal homeostatic proliferation of naive and memory CD8+ T cells. J. Exp. Med. 195: 1515-1522.",{"doi":2041},"10.1084\u002Fjem.20020033",{"id":24,"text":2043,"url":24,"identifiers":2044},"Giri, J. G., M. Ahdieh, J. Eisenman, K. Shanebeck, K. Grabstein, S. Kumaki, A. Namen, L. S. Park, D. Cosman, D. Anderson. 1994. Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J. 13: 2822-2830.",{"doi":2045},"10.1002\u002Fj.1460-2075.1994.tb06576.x",{"id":24,"text":2047,"url":24,"identifiers":2048},"Giri, J. G., S. Kumaki, M. Ahdieh, D. J. Friend, A. Loomis, K. Shanebeck, R. DuBose, D. Cosman, L. S. Park, D. M. Anderson. 1995. Identification and cloning of a novel IL-15 binding protein that is structurally related to the α chain of the IL-2 receptor. EMBO J. 15: 3654-3633.",{"doi":2049},"10.1002\u002Fj.1460-2075.1995.tb00035.x",{"id":24,"text":2051,"url":24,"identifiers":2052},"de Jong, J. L., N. L. Farner, M. B. Widmer, J. G. Giri, P. M. Sondel. 1996. Interaction of IL-15 with the shared IL-2 receptor β and γ c subunits: the IL-15\u002Fβ\u002Fγ c receptor-ligand complex is less stable than the IL-2\u002Fβ\u002Fγ c receptor-ligand complex. J. Immunol. 156: 1339-1348.",{"doi":2053},"10.4049\u002Fjimmunol.156.4.1339",{"id":24,"text":2055,"url":24,"identifiers":2056},"Bulfone-Paus, S., E. Bulanova, T. Pohl, V. Budagian, H. Durkop, R. Ruckert, U. Kunzendorf, R. Paus, H. Krause. 1999. Death deflected: IL-15 inhibits TNF-α-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Rα chain. FASEB J. 13: 1575-1585.",{"doi":2057},"10.1096\u002Ffasebj.13.12.1575",{"id":24,"text":2059,"url":24,"identifiers":2060},"Bulanova, E., V. Budagian, T. Pohl, H. Krause, H. Durkop, R. Paus, S. Bulfone-Paus. 2001. The IL-15Rα chain signals through association with Syk in human B cells. J. Immunol. 167: 6292-6302.",{"doi":2061},"10.4049\u002Fjimmunol.167.11.6292",{"id":24,"text":2063,"url":24,"identifiers":2064},"Bulfone-Paus, S., E. Bulanova, V. Budagian, R. Paus. 2006. The interleukin-15\u002Finterleukin-15 receptor system as a model for juxtacrine and reverse signaling. BioEssays 28: 362-377.",{"doi":2065},"10.1002\u002Fbies.20380",{"id":24,"text":2067,"url":24,"identifiers":2068},"Lodolce, J. P., P. R. Burkett, D. L. Boone, M. Chien, A. Ma. 2001. T cell-independent interleukin 15Rα signals are required for bystander proliferation. J. Exp. Med. 194: 1187-1194.",{"doi":2069},"10.1084\u002Fjem.194.8.1187",{"id":24,"text":2071,"url":24,"identifiers":2072},"Dubois, S., J. Mariner, T. A. Waldmann, Y. Tagaya. 2002. IL-15Rα recycles and presents IL-15 in trans to neighboring cells. Immunity 17: 537-547.",{"doi":2073},"10.1016\u002FS1074-7613(02)00429-6",{"id":24,"text":2075,"url":24,"identifiers":2076},"Burkett, P. R., R. Koka, M. Chien, S. Chai, F. Chan, A. Ma, D. L. Boone. 2003. IL-15Rα expression on CD8+ T cells is dispensable for T cell memory. Proc. Natl. Acad. Sci. USA 100: 4724-4729.",{"doi":2077},"10.1073\u002Fpnas.0737048100",{"id":24,"text":2079,"url":24,"identifiers":2080},"Koka, R., P. R. Burkett, M. Chien, S. Chai, F. Chan, J. P. Lodolce, D. L. Boone, A. Ma. 2003. Interleukin (IL)-15Rα-deficient natural killer cells survive in normal but not IL-15Rα-deficient mice. J. Exp. Med. 197: 977-984.",{"doi":2081},"10.1084\u002Fjem.20021836",{"id":24,"text":2083,"url":24,"identifiers":2084},"Schluns, K. S., E. C. Nowak, A. Cabrera-Hernandez, L. Puddington, L. Lefrancois, H. L. Aguila. 2004. Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor α expression. Proc. Natl. Acad. Sci. USA 101: 5616-5621.",{"doi":2085},"10.1073\u002Fpnas.0307442101",{"id":24,"text":2087,"url":24,"identifiers":2088},"Schluns, K. S., K. D. Klonowski, L. Lefrançois. 2004. Transregulation of memory CD8 T cell proliferation by IL-15Rα+ bone marrow-derived cells. Blood 103: 988-994.",{"doi":2089},"10.1182\u002Fblood-2003-08-2814",{"id":24,"text":2091,"url":24,"identifiers":2092},"Burkett, P. R., R. Koka, M. Chien, S. Chai, D. L. Boone, A. Ma. 2004. Coordinate expression and trans presentation of interleukin (IL)-15Rα and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis. J. Exp. Med. 200: 825-834.",{"doi":2093},"10.1084\u002Fjem.20041389",{"id":24,"text":2095,"url":24,"identifiers":2096},"Sandau, M. M., K. S. Schluns, L. Lefrancois, S. C. Jameson. 2004. Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15Rα by the same cells. J. Immunol. 173: 6537-6541.",{"doi":2097},"10.4049\u002Fjimmunol.173.11.6537",{"id":24,"text":2099,"url":24,"identifiers":2100},"Mortier, E., A. Quemener, P. Vusio, I. Lorenzen, Y. Boublik, J. Grotzinger, A. Plet, Y. Jacques. 2006. Soluble interleukin-15 receptor α (IL-15Rα)-sushi as a selective and potent agonist of IL-15 action through IL-15Rβ\u002Fγ: hyperagonist IL-15 × IL-15Rα fusion proteins. J. Biol. Chem. 281: 1612-1619.",{"doi":2101},"10.1074\u002Fjbc.M508624200",{"id":24,"text":2103,"url":24,"identifiers":2104},"Giron-Michel, J., M. Giuliani, M. Fogli, D. Brouty-Boye, S. Ferrini, F. Baychelier, P. Eid, C. Lebousse-Kerdiles, D. Durali, R. Biassoni, et al 2005. Membrane-bound and soluble IL-15\u002FIL-15Rα complexes display differential signaling and functions on human hematopoietic progenitors. Blood 106: 2302-2310.",{"doi":2105},"10.1182\u002Fblood-2005-01-0064",{"id":24,"text":2107,"url":24,"identifiers":2108},"Ferrari-Lacraz, S., E. Zanelli, M. Neuberg, E. Donskoy, Y. S. Kim, X. X. Zheng, W. W. Hancock, W. Maslinski, X. C. Li, T. B. Strom, T. Moll. 2004. Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15\u002FFc protein prevents disease development and progression in murine collagen-induced arthritis. J. Immunol. 173: 5818-5826.",{"doi":2109},"10.4049\u002Fjimmunol.173.9.5818",{"id":24,"text":2111,"url":24,"identifiers":2112},"Ruchatz, H., B. P. Leung, X. Q. Wei, I. B. McInnes, F. Y. Liew. 1998. Soluble IL-15 receptor α-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology. J. Immunol. 160: 5654-5660.",{"doi":2113},"10.4049\u002Fjimmunol.160.11.5654",{"id":24,"text":2115,"url":24,"identifiers":2116},"Smith, X. G., E. M. Bolton, H. Ruchatz, X. Wei, F. Y. Liew, J. A. Bradley. 2000. Selective blockade of IL-15 by soluble IL-15 receptor α-chain enhances cardiac allograft survival. J. Immunol. 165: 3444-3450.",{"doi":2117},"10.4049\u002Fjimmunol.165.6.3444",{"id":24,"text":2119,"url":24,"identifiers":2120},"Khan, I. A., L. H. Kasper. 1996. IL-15 augments CD8+ T cell-mediated immunity against Toxoplasma gondii infection in mice. J. Immunol. 157: 2103-2108.",{"doi":2121},"10.4049\u002Fjimmunol.157.5.2103",{"id":24,"text":2123,"url":24,"identifiers":2124},"Tsunobuchi, H., H. Nishimura, F. Goshima, T. Daikoku, H. Suzuki, I. Nakashima, Y. Nishiyama, Y. Yoshikai. 2000. A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus. Virology 275: 57-66.",{"doi":2125},"10.1006\u002Fviro.2000.0455",{"id":24,"text":2127,"url":24,"identifiers":2128},"Maeurer, M. J., P. Trinder, G. Hommel, W. Walter, K. Freitag, D. Atkins, S. Storkel. 2000. Interleukin-7 or interleukin-15 enhances survival of Mycobacterium tuberculosis-infected mice. Infect. Immun. 68: 2962-2970.",{"doi":2129},"10.1128\u002FIAI.68.5.2962-2970.2000",{"id":24,"text":2131,"url":24,"identifiers":2132},"Umemura, M., H. Nishimura, K. Hirose, T. Matsuguchi, Y. Yoshikai. 2001. Overexpression of IL-15 in vivo enhances protection against Mycobacterium bovis bacillus Calmette-Guerin infection via augmentation of NK and T cytotoxic 1 responses. J. Immunol. 167: 946-956.",{"doi":2133},"10.4049\u002Fjimmunol.167.2.946",{"id":24,"text":2135,"url":24,"identifiers":2136},"Rubinstein, M. P., A. N. Kadima, M. L. Salem, C. L. Nguyen, W. E. Gillanders, D. J. Cole. 2002. Systemic administration of IL-15 augments the antigen-specific primary CD8+ T cell response following vaccination with peptide-pulsed dendritic cells. J. Immunol. 169: 4928-4935.",{"doi":2137},"10.4049\u002Fjimmunol.169.9.4928",{"id":24,"text":2139,"url":24,"identifiers":2140},"Oh, S., J. A. Berzofsky, D. S. Burke, T. A. Waldmann, L. P. Perera. 2003. Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity. Proc. Natl. Acad. Sci. USA 100: 3392-3397.",{"doi":2141},"10.1073\u002Fpnas.0630592100",{"id":24,"text":2143,"url":24,"identifiers":2144},"Hiromatsu, T., T. Yajima, T. Matsuguchi, H. Nishimura, W. Wajjwalku, T. Arai, Y. Nimura, Y. Yoshikai. 2003. Overexpression of interleukin-15 protects against Escherichia coli-induced shock accompanied by inhibition of tumor necrosis factor-α-induced apoptosis. J. Infect. Dis. 187: 1442-1451.",{"doi":2145},"10.1086\u002F374643",{"id":24,"text":2147,"url":24,"identifiers":2148},"Toka, F. N., B. T. Rouse. 2005. Mucosal application of plasmid-encoded IL-15 sustains a highly protective anti-Herpes simplex virus immunity. J. Leukocyte Biol. 78: 178-186.",{"doi":2149},"10.1189\u002Fjlb.1004621",{"id":24,"text":2151,"url":24,"identifiers":2152},"Melchionda, F., T. J. Fry, M. J. Milliron, M. A. McKirdy, Y. Tagaya, C. L. Mackall. 2005. Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool. J. Clin. Invest. 115: 1177-1187.",{"doi":2153},"10.1172\u002FJCI200523134",{"id":24,"text":2155,"url":24,"identifiers":2156},"Bamford, R. N., A. P. DeFilippis, N. Azimi, G. Kurys, T. A. Waldmann. 1998. The 5′ untranslated region, signal peptide, and the coding sequence of the carboxyl terminus of IL-15 participate in its multifaceted translational control. J. Immunol. 160: 4418-4426.",{},{"id":24,"text":2158,"url":24,"identifiers":2159},"Mastroianni, C. M., G. d’Ettorre, G. Forcina, M. Lichtner, F. Mengoni, C. D’Agostino, A. Corpolongo, A. P. Massetti, V. Vullo. 2000. Interleukin-15 enhances neutrophil functional activity in patients with human immunodeficiency virus infection. Blood 96: 1979-1984.",{"doi":2160},"10.1182\u002Fblood.V96.5.1979.h8001979_1979_1984",{"id":24,"text":2162,"url":24,"identifiers":2163},"Chitnis, V., R. Pahwa, S. Pahwa. 2003. Determinants of HIV-specific CD8 T-cell responses in HIV-infected pediatric patients and enhancement of HIV-gag-specific responses with exogenous IL-15. Clin. Immunol. 107: 36-45.",{"doi":2164},"10.1016\u002FS1521-6616(02)00051-7",{"id":24,"text":2166,"url":24,"identifiers":2167},"Mueller, Y. M., P. M. Bojczuk, E. S. Halstead, A. H. J. Kim, J. Witek, J. D. Altman, P. D. Katsikis. 2003. IL-15 enhances survival and function of HIV-specific CD8+ T cells. Blood 101: 1024-1029.",{"doi":2168},"10.1182\u002Fblood-2002-07-1957",{"id":24,"text":2170,"url":24,"identifiers":2171},"Castelli, J., E. K. Thomas, M. Gilliet, Y. J. Liu, J. A. Levy. 2004. Mature dendritic cells can enhance CD8+ cell noncytotoxic anti-HIV responses: the role of IL-15. Blood 103: 2699-2704.",{"doi":2172},"10.1182\u002Fblood-2003-06-1913",{"id":24,"text":2174,"url":24,"identifiers":2175},"Lum, J. J., D. J. Schnepple, Z. Nie, J. Sanchez-Dardon, G. L. Mbisa, J. Mihowich, N. Hawley, S. Narayan, J. E. Kim, D. H. Lynch, A. D. Badley. 2004. Differential effects of interleukin-7 and interleukin-15 on NK cell anti-human immunodeficiency virus activity. J. Virol. 78: 6033-6042.",{"doi":2176},"10.1128\u002FJVI.78.11.6033-6042.2004",{"id":24,"text":2178,"url":24,"identifiers":2179},"Forcina, G., G. d’Ettorre, C. M. Mastroianni, M. Carnevalini, L. Scorzolini, G. Ceccarelli, C. D’Agostino, M. Lichtner, A. P. Massetti, V. Vullo. 2004. Interleukin-15 modulates interferon-γ and β-chemokine production in patients with HIV infection: implications for immune-based therapy. Cytokine 25: 283-290.",{"doi":2180},"10.1016\u002Fj.cyto.2003.12.004",{"id":24,"text":2182,"url":24,"identifiers":2183},"Alpdogan, O., J. M. Eng, S. J. Muriglan, L. M. Willis, V. M. Hubbard, K. H. Tjoe, T. H. Terwey, A. Kochman, M. R. M. van den Brink. 2005. Interleukin-15 enhances immune reconstitution after allogenic bone marrow transplantation. Blood 105: 865-873.",{"doi":2184},"10.1182\u002Fblood-2003-09-3344",{"id":24,"text":2186,"url":24,"identifiers":2187},"Chapoval, A. I., J. A. Fuller, S. G. Kremlev, S. J. Kamdar, R. Evans. 1998. Combination chemotherapy and IL-15 administration induce permanent tumor regression in a mouse lung tumor model: NK and T cell-mediated effects antagonized by B cells. J. Immunol. 161: 6977-6984.",{"doi":2188},"10.4049\u002Fjimmunol.161.12.6977",{"id":24,"text":2190,"url":24,"identifiers":2191},"Wysocka, M., B. M. Benoit, S. Newton, L. Azzoni, L. J. Montaner, A. H. Rook. 2004. Enhancement of the host immune responses in cutaneous T-cell lymphoma by CpG oligodeoxynucleotides and IL-15. Blood 104: 4142-4149.",{"doi":2192},"10.1182\u002Fblood-2004-03-1190",{"id":24,"text":2194,"url":24,"identifiers":2195},"Klebanoff, C. A., S. E. Finkelstein, D. R. Surman, M. K. Lichtman, L. Gattinoni, M. R. Theoret, N. Grewal, P. J. Spiess, P. A. Antony, D. C. Palmer, et al 2004. IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells. Proc. Natl. Acad. Sci. USA 101: 1969-1974.",{"doi":2196},"10.1073\u002Fpnas.0307298101",{"id":24,"text":2198,"url":24,"identifiers":2199},"von Freeden-Jeffry, U., P. Vieira, L. A. Lucian, T. McNeil, S. E. G. Burdach, R. Murray. 1995. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181: 1519-1526.",{"doi":2200},"10.1084\u002Fjem.181.4.1519",{"id":24,"text":2202,"url":24,"identifiers":2203},"Lyons, A. B., C. R. Parish. 1994. Determination of lymphocyte division by flow cytometry. J. Immunol. Methods 171: 131-137.",{"doi":2204},"10.1016\u002F0022-1759(94)90236-4",{"id":24,"text":2206,"url":24,"identifiers":2207},"Gudmundsdottir, H., A. D. Wells, L. A. Turka. 1999. Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity. J. Immunol. 162: 5212-5223.",{"doi":2208},"10.4049\u002Fjimmunol.162.9.5212",{"id":24,"text":2210,"url":24,"identifiers":2211},"Altman, J. D., P. A. H. Moss, P. J. R. Goulder, D. H. Barouch, M. G. McHeyzer-Williams, J. I. Bell, A. J. McMichael, M. M. Davis. 1996. Phenotypic analysis of antigen-specific T lymphocytes. Science 274: 94-96.",{"doi":546},{"id":24,"text":2213,"url":24,"identifiers":2214},"Masopust, D., J. Jiang, H. Shen, L. Lefrançois. 2001. Direct analysis of the dynamics of the intestinal mucosa CD8 T cell response to systemic virus infection. J. Immunol. 166: 2348-2356.",{"doi":2215},"10.4049\u002Fjimmunol.166.4.2348",{"id":24,"text":2217,"url":24,"identifiers":2218},"Oehen, S., K. Brduscha-Riem. 1998. Differentiation of naive CTL to effector and memory CTL: correlation of effector function with phenotype and cell division. J. Immunol. 161: 5338-5346.",{"doi":2219},"10.4049\u002Fjimmunol.161.10.5338",{"id":24,"text":2221,"url":24,"identifiers":2222},"Kim, S. K., D. S. Reed, S. Olson, M. J. Schnell, J. K. Rose, P. A. Morton, L. Lefrançois. 1998. Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals. Proc. Natl. Acad. Sci. USA 95: 10814-10819.",{"doi":2223},"10.1073\u002Fpnas.95.18.10814",{"id":24,"text":2225,"url":24,"identifiers":2226},"Carson, W. E., J. G. Giri, M. J. Lindemann, M. L. Linett, M. Ahdieh, R. Paxton, D. Anderson, J. Eisenmann, K. Grabstein, M. A. Caligiuri. 1994. Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J. Exp. Med. 180: 1395-1403.",{"doi":2227},"10.1084\u002Fjem.180.4.1395",{"id":24,"text":2229,"url":24,"identifiers":2230},"Dunne, J., S. Lynch, C. O’Farrelly, S. Todryk, J. E. Hegarty, C. Feighery, D. G. Doherty. 2001. Selective expansion and partial activation of human NK cells and NK receptor-positive T cells by IL-2 and IL-15. J. Immunol. 167: 3129-3138.",{"doi":2231},"10.4049\u002Fjimmunol.167.6.3129",{"id":24,"text":2233,"url":24,"identifiers":2234},"Warren, H. S., B. F. Kinnear, R. L. Kastelein, L. L. Lanier. 1996. Analysis of the costimulatory role of IL-2 and IL-15 in initiating proliferation of resting (CD56dim) human NK cells. J. Immunol. 156: 3254-3259.",{"doi":2235},"10.4049\u002Fjimmunol.156.9.3254",{"id":24,"text":2237,"url":24,"identifiers":2238},"Armitage, R. J., B. M. Macduff, J. Eisenman, R. Paxton, K. H. Grabstein. 1995. IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J. Immunol. 154: 483-490.",{"doi":2239},"10.4049\u002Fjimmunol.154.2.483",{"id":24,"text":2241,"url":24,"identifiers":2242},"Tan, J. T., B. Ernst, W. C. Kieper, E. LeRoy, J. Sprent, C. D. Surh. 2002. Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J. Exp. Med. 195: 1523-1532.",{"doi":2243},"10.1084\u002Fjem.20020066",{"id":24,"text":2245,"url":24,"identifiers":2246},"Park, C. S., S. O. Yoon, R. J. Armitage, Y. S. Choi. 2004. Follicular dendritic cells produce IL-15 that enhances germinal center B cell proliferation in membrane-bound form. J. Immunol. 173: 6676-6683.",{"doi":2247},"10.4049\u002Fjimmunol.173.11.6676",{"id":24,"text":2249,"url":24,"identifiers":2250},"Schluns, K. S., W. C. Kieper, S. C. Jameson, L. Lefrançois. 2000. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol. 1: 426-432.",{"doi":2251},"10.1038\u002F80868",{"id":24,"text":2253,"url":24,"identifiers":2254},"Roychowdhury, S., K. F. May, Jr, K. S. Tzou, T. Lin, D. Bhatt, A. G. Freud, M. Guimond, A. K. Ferketich, Y. Liu, M. A. Caligiuri. 2004. Failed adoptive immunotherapy with tumor-specific T cells: reversal with low-dose interleukin 15 but not low-dose interleukin 2. Cancer Res. 64: 8062-8067.",{"doi":2255},"10.1158\u002F0008-5472.CAN-04-1860",{"id":24,"text":2257,"url":24,"identifiers":2258},"Zeng, R., R. Spolski, S. E. Finkelstein, S. Oh, P. E. Kovanen, C. S. Hinricjs, C. A. Pise-Masison, M. F. Radonovich, J. N. Brady, N. P. Restifo, et al 2005. Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function. J. Exp. Med. 201: 139-148.",{"doi":2259},"10.1084\u002Fjem.20041057",{"id":24,"text":2261,"url":24,"identifiers":2262},"Alpdogan, O., M. R. M. van den Brink. 2005. IL-7 and IL-15: therapeutic cytokines for immunodeficiency. Trends Immunol. 26: 56-64.",{"doi":2263},"10.1016\u002Fj.it.2004.11.002",{"id":24,"text":2265,"url":24,"identifiers":2266},"Dummer, W., A. G. Niethammer, R. Baccala, B. R. Lawson, N. Wagner, R. A. Reisfeld, A. N. Theofilopoulos. 2002. T cell homeostatic proliferation elicits effective antitumor autoimmunity. J. Clin. Invest. 110: 185-192.",{"doi":2267},"10.1172\u002FJCI0215175",{"id":24,"text":2269,"url":24,"identifiers":2270},"Baccala, R., R. Gonzalez-Quintial, W. Dummer, A. N. Theofilopoulos. 2005. Tumor immunity via homeostatic T cell proliferation: mechanistic aspects and clinical perspectives. Springer Semin. Immunopathol. 27: 75-85.",{"doi":2271},"10.1007\u002Fs00281-004-0196-9",{"id":24,"text":2273,"url":24,"identifiers":2274},"Wrzesinski, C., N. P. Restifo. 2005. Less is more: lymphodepletion followed by hematopoietic stem cell transplant augments adoptive T-cell-based anti-tumor immunotherapy. Curr. Opin. Immunol. 17: 195-201.",{"doi":2275},"10.1016\u002Fj.coi.2005.02.002",{"id":24,"text":2277,"url":24,"identifiers":2278},"Dudley, M. E., J. R. Wunderlich, J. C. Yang, R. M. Sherry, S. L. Topalian, N. P. Restifo, R. E. Royal, U. Kammula, D. E. White, S. A. Mavroukakis, et al 2005. Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma. J. Clin. Oncol. 23: 2346-2357.",{"doi":2279},"10.1200\u002FJCO.2005.00.240",{"id":24,"text":2281,"url":24,"identifiers":2282},"Porter, D. L., C. H. June. 2005. T-cell reconstitution and expansion after hematopoietic stem cell transplantation: ‘T’ it up!. Bone Marrow Transplant. 35: 935-942.",{"doi":2283},"10.1038\u002Fsj.bmt.1704953",{"id":24,"text":2285,"url":24,"identifiers":2286},"Cho, B. K., V. P. Rao, Q. Ge, H. N. Eisen, J. Chen. 2000. Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells. J. Exp. Med. 192: 549-556.",{"doi":2287},"10.1084\u002Fjem.192.4.549",{"id":24,"text":2289,"url":24,"identifiers":2290},"Kieper, W. C., S. C. Jameson. 2000. Homeostatic expansion and phenotypic conversion of naive T cells in response to self peptide\u002FMHC ligands. Proc. Natl. Acad. Sci. USA 96: 13306-13311.",{"doi":2291},"10.1073\u002Fpnas.96.23.13306",{"id":24,"text":2293,"url":24,"identifiers":2294},"Ruckert, R., K. Brandt, E. Bulanova, F. Mirghomizadeh, R. Paus, S. Bulfone-Paus. 2003. Dendritic cell-derived IL-15 controls the induction of CD8 T cell immune responses. Eur. J. Immunol. 33: 3493-3503.",{"doi":2295},"10.1002\u002Feji.200324545",{"id":24,"text":2297,"url":24,"identifiers":2298},"Prlic, M., B. R. Blazar, M. A. Farrar, S. C. Jameson. 2003. In vivo survival and homeostatic proliferation of natural killer cells. J. Exp. Med. 197: 967-976.",{"doi":2299},"10.1084\u002Fjem.20021847",{"id":24,"text":2301,"url":24,"identifiers":2302},"Cookson, S., D. Reen. 2003. IL-15 drives neonatal T cells to acquire CD56 and become activated effector cells. Blood 102: 2195-2197.",{"doi":2303},"10.1182\u002Fblood-2003-01-0232",{"id":24,"text":2305,"url":24,"identifiers":2306},"Alves, N. L., B. Hooibrink, F. A. Arosa, R. A. van Lier. 2003. IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro. Blood 102: 2541-2546.",{"doi":2307},"10.1182\u002Fblood-2003-01-0183",{"id":24,"text":2309,"url":24,"identifiers":2310},"Liu, K., M. Catalfamo, Y. Li, P. A. Henkart, N. P. Weng. 2002. IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells. Proc. Natl. Acad. Sci. USA 99: 6192-6197.",{"doi":2311},"10.1073\u002Fpnas.092675799",{"id":24,"text":2313,"url":24,"identifiers":2314},"Ruckert, R., K. Brandt, A. Braun, H. G. Hoymann, U. Herz, V. Budagian, H. Durkop, H. Renz, S. Bulfone-Paus. 2005. Blocking IL-15 prevents the induction of allergen-specific T cells and allergic inflammation in vivo. J. Immunol. 174: 5507-5515.",{"doi":2315},"10.4049\u002Fjimmunol.174.9.5507",{"id":24,"text":2317,"url":24,"identifiers":2318},"Budagian, V., E. Bulanova, Z. Orinska, T. Pohl, E. C. Borden, R. Silverman, S. Bulfone-Paus. 2004. Reverse signaling through membrane-bound interleukin-15. J. Biol. Chem. 279: 42192-42201.",{"doi":2319},"10.1074\u002Fjbc.M403182200",{"id":24,"text":2321,"url":24,"identifiers":2322},"Rubinstein, M. P., M. Kovar, J. F. Purton, J. H. Cho, O. Boyman, C. D. Surh, J. Sprent. 2006. Converting IL-15 to a superagonist by binding to soluble IL-15Rα. Proc. Natl. Acad. Sci. USA 103: 9166-9171.",{"doi":2323},"10.1073\u002Fpnas.0600240103",{"id":2325,"createTime":2326,"updateTime":2327,"relativeEntities":2328,"slug":2329,"properties":2330,"entityType":295,"verifyStatus":296,"verifyTime":2345,"verifyNote":297,"languages":2346,"translateLanguages":24,"viewCount":25,"primaryUrl":2347,"fullTextUrl":24,"authors":2348,"publicationType":423,"publisherRelationship":2596,"citationCount":113,"citationInfo":2651,"publishDate":2654,"publishYear":2652,"citationAnalyzeStatus":23,"lastCitationAnalyze":2655,"indexDatabases":2656,"openAccess":24,"references":2657,"isForceReanalyzing":615},"a73f2d08-e660-4818-815f-3fcf253a10a1","2024-12-12T07:19:38.755+00:00","2026-07-21T03:34:04.993+00:00",[],"Expansion-of-Group-2-Innate-Lymphoid-Cells-in-Patients-with-End-Stage-Renal-Disease-and-Their-Clinical-Significance",{"mag":2331,"gsPaper":2333,"openalex":2335,"abstract":2337,"title":2339,"pm":2341,"doi":2343},{"VOID":2332},"3027198349",{"VOID":2334},"[\"4951921863675510307\"]",{"VOID":2336},"W3027198349",{"EN":2338},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:p>Group 2 innate lymphoid cells (ILC2s) play an important role in the control of tissue inflammation and homeostasis. However, the role of ILC2s in patients with end-stage renal disease (ESRD) has never been illustrated. In this study, we investigated ILC2s in ESRD patients and their clinical significance. Results showed that the frequencies and absolute numbers of ILC2s, not group 1 innate lymphoid cells or innate lymphoid cell precursors, were significantly elevated in the peripheral blood of ESRD patients when compared with those from healthy donor controls. Moreover, ILC2s from ESRD patients displayed enhanced type 2 cytokine production and cell proliferation. Plasma from ESRD patients significantly increased ILC2 levels and enhanced their effector function after in vitro treatment. The expression of phosphorylation of STAT5 in ILC2s, as well as the amounts of IL-2 in plasma, were increased in ESRD patients when compared with those from healthy donors. Clinically, ESRD patients with higher ILC2 frequencies displayed lower incidence of infectious complications during a mean of 21 month follow-up study. The proportions of ILC2s were negatively correlated with the prognostic biomarkers of chronic kidney disease, including serum parathyroid hormone, creatinine, and phosphorus, whereas they were positively correlated with serum calcium. These observations indicate that ILC2s may play a protective role in ESRD.\u003C\u002Fjats:p>",{"EN":2340},"Expansion of Group 2 Innate Lymphoid Cells in Patients with End-Stage Renal Disease and Their Clinical Significance",{"VOID":2342},"32444391",{"VOID":2344},"10.4049\u002Fjimmunol.1901095","2024-12-12T07:19:38.754+00:00",[299],"https:\u002F\u002Fjournals.aai.org\u002Fjimmunol\u002Farticle\u002F205\u002F1\u002F36\u002F110127\u002FExpansion-of-Group-2-Innate-Lymphoid-Cells-in",[2349,2382,2411,2430,2459,2478,2495,2520,2539,2556,2573],{"id":2350,"sortIndex":25,"researcher":24,"roles":2351,"affiliations":2352,"properties":2377,"displayName":2379,"givenName":24,"familyName":24},"698ed590-3eb9-493a-9540-840c5a56d01f",[],[2353,2361,2369],{"id":2354,"sortIndex":25,"affiliation":2355,"properties":24},"be974742-8a47-466e-a8c7-b88be8ce3a17",{"id":2354,"createTime":24,"updateTime":24,"relativeEntities":2356,"slug":24,"properties":2357,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2360,"statistic":24},[],{"title":2358},{"EN":2359},"*Joint Program in Immunology, Department of Internal Medicine, Affiliated Guangzhou Women and Children’s Medical Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510623, China;",[],{"id":2362,"sortIndex":110,"affiliation":2363,"properties":24},"4853df5b-0eda-4068-9ec1-9d2ca1375b55",{"id":2362,"createTime":24,"updateTime":24,"relativeEntities":2364,"slug":24,"properties":2365,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2368,"statistic":24},[],{"title":2366},{"VI":2367},"Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China",[],{"id":2370,"sortIndex":109,"affiliation":2371,"properties":24},"088d04a8-2666-48d0-8d8b-fdf88e32b129",{"id":2370,"createTime":24,"updateTime":24,"relativeEntities":2372,"slug":24,"properties":2373,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2376,"statistic":24},[],{"title":2374},{"VI":2375},"Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China",[],{"title":2378,"openalex":2380},{"EN":2379},"Gao-Yu Liu",{"VOID":2381},"A5053398580",{"id":2383,"sortIndex":110,"researcher":24,"roles":2384,"affiliations":2385,"properties":2404,"displayName":2408,"givenName":24,"familyName":24},"bdad687f-a3cc-43ce-ab95-0c397340994b",[],[2386,2392,2398],{"id":2354,"sortIndex":25,"affiliation":2387,"properties":24},{"id":2354,"createTime":24,"updateTime":24,"relativeEntities":2388,"slug":24,"properties":2389,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2391,"statistic":24},[],{"title":2390},{"EN":2359},[],{"id":2362,"sortIndex":110,"affiliation":2393,"properties":24},{"id":2362,"createTime":24,"updateTime":24,"relativeEntities":2394,"slug":24,"properties":2395,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2397,"statistic":24},[],{"title":2396},{"VI":2367},[],{"id":2370,"sortIndex":109,"affiliation":2399,"properties":24},{"id":2370,"createTime":24,"updateTime":24,"relativeEntities":2400,"slug":24,"properties":2401,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2403,"statistic":24},[],{"title":2402},{"VI":2375},[],{"orcid":2405,"title":2407,"openalex":2409},{"VOID":2406},"https:\u002F\u002Forcid.org\u002F0000-0003-0030-439X",{"EN":2408},"Xiaohui Deng",{"VOID":2410},"A5101987668",{"id":2412,"sortIndex":109,"researcher":24,"roles":2413,"affiliations":2414,"properties":2423,"displayName":2427,"givenName":24,"familyName":24},"c86d131b-0407-460e-b23b-07631f15997e",[],[2415],{"id":2416,"sortIndex":25,"affiliation":2417,"properties":24},"74483230-1778-4d53-b153-c0b3c22c0a6b",{"id":2416,"createTime":24,"updateTime":24,"relativeEntities":2418,"slug":24,"properties":2419,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2422,"statistic":24},[],{"title":2420},{"VI":2421},"Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China",[],{"orcid":2424,"title":2426,"openalex":2428},{"VOID":2425},"https:\u002F\u002Forcid.org\u002F0000-0001-9145-4769",{"EN":2427},"Xing Li",{"VOID":2429},"A5100358650",{"id":2431,"sortIndex":111,"researcher":24,"roles":2432,"affiliations":2433,"properties":2452,"displayName":2456,"givenName":24,"familyName":24},"ec0217dc-74af-4a39-88c3-3ebeefdf8727",[],[2434,2440,2446],{"id":2354,"sortIndex":25,"affiliation":2435,"properties":24},{"id":2354,"createTime":24,"updateTime":24,"relativeEntities":2436,"slug":24,"properties":2437,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2439,"statistic":24},[],{"title":2438},{"EN":2359},[],{"id":2362,"sortIndex":110,"affiliation":2441,"properties":24},{"id":2362,"createTime":24,"updateTime":24,"relativeEntities":2442,"slug":24,"properties":2443,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2445,"statistic":24},[],{"title":2444},{"VI":2367},[],{"id":2370,"sortIndex":109,"affiliation":2447,"properties":24},{"id":2370,"createTime":24,"updateTime":24,"relativeEntities":2448,"slug":24,"properties":2449,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2451,"statistic":24},[],{"title":2450},{"VI":2375},[],{"orcid":2453,"title":2455,"openalex":2457},{"VOID":2454},"https:\u002F\u002Forcid.org\u002F0000-0003-1689-0397",{"EN":2456},"Yingjiao Cao",{"VOID":2458},"A5103132739",{"id":2460,"sortIndex":112,"researcher":24,"roles":2461,"affiliations":2462,"properties":2471,"displayName":2475,"givenName":24,"familyName":24},"44400eeb-5e32-4130-8348-8903ee346a13",[],[2463],{"id":2464,"sortIndex":25,"affiliation":2465,"properties":24},"e4378319-fd8d-44a6-99f9-bde23f6f6614",{"id":2464,"createTime":24,"updateTime":24,"relativeEntities":2466,"slug":24,"properties":2467,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2470,"statistic":24},[],{"title":2468},{"EN":2469},"¶Department of Nephrology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China;",[],{"orcid":2472,"title":2474,"openalex":2476},{"VOID":2473},"https:\u002F\u002Forcid.org\u002F0000-0002-7337-6709",{"EN":2475},"Yan‐Fang Xing",{"VOID":2477},"A5015633119",{"id":2479,"sortIndex":113,"researcher":24,"roles":2480,"affiliations":2481,"properties":2488,"displayName":2492,"givenName":24,"familyName":24},"8c1eb696-e454-480b-8361-224719696d5a",[],[2482],{"id":2370,"sortIndex":25,"affiliation":2483,"properties":24},{"id":2370,"createTime":24,"updateTime":24,"relativeEntities":2484,"slug":24,"properties":2485,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2487,"statistic":24},[],{"title":2486},{"VI":2375},[],{"orcid":2489,"title":2491,"openalex":2493},{"VOID":2490},"https:\u002F\u002Forcid.org\u002F0000-0002-7105-6808",{"EN":2492},"Pan Zhou",{"VOID":2494},"A5103200639",{"id":2496,"sortIndex":144,"researcher":24,"roles":2497,"affiliations":2498,"properties":2513,"displayName":2517,"givenName":24,"familyName":24},"63c52f83-bc50-4c98-9e5f-f431e47dd1da",[],[2499,2507],{"id":2500,"sortIndex":25,"affiliation":2501,"properties":24},"0c6ceea3-d745-4597-add4-3de7e33a3887",{"id":2500,"createTime":24,"updateTime":24,"relativeEntities":2502,"slug":24,"properties":2503,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2506,"statistic":24},[],{"title":2504},{"EN":2505},"‖Institute of Pathogenic Biology, Hengyang Medical College, University of South China, Hengyang 421008, China; and",[],{"id":2370,"sortIndex":110,"affiliation":2508,"properties":24},{"id":2370,"createTime":24,"updateTime":24,"relativeEntities":2509,"slug":24,"properties":2510,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2512,"statistic":24},[],{"title":2511},{"VI":2375},[],{"orcid":2514,"title":2516,"openalex":2518},{"VOID":2515},"https:\u002F\u002Forcid.org\u002F0000-0002-1498-5520",{"EN":2517},"Aihua Lei",{"VOID":2519},"A5047035162",{"id":2521,"sortIndex":143,"researcher":24,"roles":2522,"affiliations":2523,"properties":2532,"displayName":2536,"givenName":24,"familyName":24},"30d14050-d092-4b95-806e-92b102c13366",[],[2524],{"id":2525,"sortIndex":25,"affiliation":2526,"properties":24},"971e8e48-d4aa-4449-b9a6-d6266d3eca3c",{"id":2525,"createTime":24,"updateTime":24,"relativeEntities":2527,"slug":24,"properties":2528,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2531,"statistic":24},[],{"title":2529},{"EN":2530},"#Key Laboratory of Immunology, Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China",[],{"orcid":2533,"title":2535,"openalex":2537},{"VOID":2534},"https:\u002F\u002Forcid.org\u002F0000-0002-2548-7252",{"EN":2536},"Quan Yang",{"VOID":2538},"A5103156955",{"id":2540,"sortIndex":102,"researcher":24,"roles":2541,"affiliations":2542,"properties":2549,"displayName":2553,"givenName":24,"familyName":24},"a95b42bc-4dba-45a9-b1f0-6e1a9bc19754",[],[2543],{"id":2370,"sortIndex":25,"affiliation":2544,"properties":24},{"id":2370,"createTime":24,"updateTime":24,"relativeEntities":2545,"slug":24,"properties":2546,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2548,"statistic":24},[],{"title":2547},{"VI":2375},[],{"orcid":2550,"title":2552,"openalex":2554},{"VOID":2551},"https:\u002F\u002Forcid.org\u002F0000-0002-9973-8130",{"EN":2553},"Kai Deng",{"VOID":2555},"A5047495310",{"id":2557,"sortIndex":116,"researcher":24,"roles":2558,"affiliations":2559,"properties":2566,"displayName":2570,"givenName":24,"familyName":24},"64c7bb4c-1bda-4f51-abdc-5197096c37d9",[],[2560],{"id":2370,"sortIndex":25,"affiliation":2561,"properties":24},{"id":2370,"createTime":24,"updateTime":24,"relativeEntities":2562,"slug":24,"properties":2563,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2565,"statistic":24},[],{"title":2564},{"VI":2375},[],{"orcid":2567,"title":2569,"openalex":2571},{"VOID":2568},"https:\u002F\u002Forcid.org\u002F0000-0003-3620-610X",{"EN":2570},"Hui Zhang",{"VOID":2572},"A5100323555",{"id":2574,"sortIndex":808,"researcher":24,"roles":2575,"affiliations":2576,"properties":2589,"displayName":2593,"givenName":24,"familyName":24},"5af956da-f876-4d75-9af0-b8f99283788b",[],[2577,2583],{"id":2354,"sortIndex":25,"affiliation":2578,"properties":24},{"id":2354,"createTime":24,"updateTime":24,"relativeEntities":2579,"slug":24,"properties":2580,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2582,"statistic":24},[],{"title":2581},{"EN":2359},[],{"id":2362,"sortIndex":110,"affiliation":2584,"properties":24},{"id":2362,"createTime":24,"updateTime":24,"relativeEntities":2585,"slug":24,"properties":2586,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2588,"statistic":24},[],{"title":2587},{"VI":2367},[],{"orcid":2590,"title":2592,"openalex":2594},{"VOID":2591},"https:\u002F\u002Forcid.org\u002F0000-0001-5964-1599",{"EN":2593},"Jie Zhou",{"VOID":2595},"A5073064156",{"url":24,"publisher":2597,"properties":2644},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2598,"slug":10,"properties":2599,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":2604,"manageAffiliations":2613,"indexDatabases":2624,"url":90,"thumbnailPath":24,"statistic":2639,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":2600,"eissn":2601,"issn":2602,"title":2603},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[2605,2609],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":2606,"label":2607,"description":2608,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":2610,"label":2611,"description":2612,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[2614,2619],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":2615,"slug":24,"properties":2616,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2618,"statistic":24},[],{"title":2617},{"EN":45},[],{"id":48,"createTime":24,"updateTime":24,"relativeEntities":2620,"slug":24,"properties":2621,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2623,"statistic":24},[],{"title":2622},{"EN":52},[],[2625,2632],{"id":56,"indexDatabase":2626,"url":69,"indexYears":24,"academicFieldIds":2631,"indexDatabaseRanking":24},{"id":58,"createTime":24,"updateTime":24,"relativeEntities":2627,"label":2628,"description":2629,"key":65,"publicationTags":2630,"standard":24},[],{"EN":61,"VI":61},{"EN":63,"VI":64},[67,68],[71],{"id":73,"indexDatabase":2633,"url":84,"indexYears":85,"academicFieldIds":2638,"indexDatabaseRanking":89},{"id":75,"createTime":24,"updateTime":24,"relativeEntities":2634,"label":2635,"description":2636,"key":81,"publicationTags":2637,"standard":24},[],{"EN":78,"VI":78},{"EN":78,"VI":80},[83],[87,88],{"impactFactor":25,"impactFactorByYear":2640,"i10Index":105,"i10IndexLast5Year":106,"totalPublication":107,"totalPublicationByYear":2641,"totalCitation":145,"totalCitationByYear":2642,"totalCitationPerPublication":210,"totalCitationPerPublicationByYear":2643,"hindexLast5Year":208,"hindex":208},{"2012":93,"2013":94,"2014":95,"2015":96,"2016":97,"2017":98,"2018":99,"2019":100,"2020":101,"2021":102,"2022":103,"2023":104},{"1938":109,"1940":110,"1946":109,"1954":110,"1956":109,"1958":110,"1959":110,"1963":110,"1965":111,"1966":112,"1967":110,"1968":112,"1969":112,"1970":111,"1971":112,"1972":113,"1973":112,"1974":111,"1975":114,"1976":115,"1977":116,"1978":115,"1979":106,"1980":117,"1981":114,"1982":115,"1983":118,"1984":106,"1985":119,"1986":120,"1987":118,"1988":121,"1989":117,"1990":122,"1991":123,"1992":124,"1993":125,"1994":126,"1995":127,"1996":128,"1997":129,"1998":130,"1999":131,"2000":132,"2001":133,"2002":134,"2003":135,"2004":135,"2005":136,"2006":137,"2007":138,"2008":139,"2009":128,"2010":140,"2011":141,"2012":128,"2013":142,"2014":121,"2015":119,"2016":120,"2017":102,"2018":143,"2020":102,"2021":144,"2022":110},{"1938":147,"1940":148,"1946":124,"1954":149,"1956":150,"1958":151,"1959":152,"1963":153,"1965":154,"1966":155,"1967":156,"1968":157,"1969":158,"1970":159,"1971":160,"1972":161,"1973":162,"1974":163,"1975":164,"1976":165,"1977":166,"1978":167,"1979":168,"1980":169,"1981":170,"1982":171,"1983":172,"1984":173,"1985":174,"1986":175,"1987":176,"1988":177,"1989":178,"1990":179,"1991":180,"1992":181,"1993":182,"1994":183,"1995":184,"1996":185,"1997":186,"1998":187,"1999":188,"2000":189,"2001":190,"2002":191,"2003":192,"2004":193,"2005":194,"2006":195,"2007":196,"2008":197,"2009":198,"2010":199,"2011":200,"2012":201,"2013":202,"2014":203,"2015":204,"2016":205,"2017":206,"2018":207,"2020":208,"2021":209,"2022":109},{"1938":212,"1940":148,"1946":213,"1954":149,"1956":214,"1958":151,"1959":152,"1963":153,"1965":215,"1966":216,"1967":156,"1968":217,"1969":218,"1970":219,"1971":220,"1972":221,"1973":222,"1974":223,"1975":224,"1976":225,"1977":226,"1978":227,"1979":228,"1980":229,"1981":230,"1982":231,"1983":232,"1984":233,"1985":234,"1986":235,"1987":236,"1988":237,"1989":238,"1990":239,"1991":240,"1992":241,"1993":242,"1994":243,"1995":244,"1996":245,"1997":246,"1998":247,"1999":248,"2000":249,"2001":250,"2002":251,"2003":252,"2004":253,"2005":254,"2006":255,"2007":256,"2008":257,"2009":258,"2010":259,"2011":260,"2012":261,"2013":262,"2014":263,"2015":264,"2016":265,"2017":266,"2018":267,"2020":268,"2021":269,"2022":109},{"issue":2645,"pages":2647,"volume":2649},{"VOID":2646},"1",{"VOID":2648},"36-44",{"VOID":2650},"205",{"total":113,"publishYear":2652,"statisticByYear":2653},2020,{"2020":110,"2021":110,"2022":109,"2023":110},"2020-07-01","2026-07-21T03:34:04.992+00:00",[67,89],[2658,2662,2666,2670,2674,2678,2682,2686,2690,2694,2698,2702,2706,2710,2714,2718,2722,2726,2729,2733,2737,2741,2745,2749,2753,2757,2761,2765,2769,2772,2776,2780,2783,2787,2791,2795,2799,2803,2807,2811,2815,2819,2823,2827,2831,2835,2839,2843,2847,2851,2855,2859,2863,2867,2871,2875,2879,2883,2886,2890,2894,2898,2902,2905,2909,2913,2917],{"id":24,"text":2659,"url":24,"identifiers":2660},"Hill, 2016, Global prevalence of chronic kidney disease - a systematic review and meta-analysis., PLoS One, 11, 10.1371\u002Fjournal.pone.0158765",{"doi":2661},"10.1371\u002Fjournal.pone.0158765",{"id":24,"text":2663,"url":24,"identifiers":2664},"Chen, 2019, Roxadustat treatment for anemia in patients undergoing long-term dialysis., N. Engl. J. Med., 381, 1011, 10.1056\u002FNEJMoa1901713",{"doi":2665},"10.1056\u002FNEJMoa1901713",{"id":24,"text":2667,"url":24,"identifiers":2668},"Webster, 2017, Chronic kidney disease., Lancet, 389, 1238, 10.1016\u002FS0140-6736(16)32064-5",{"doi":2669},"10.1016\u002FS0140-6736(16)32064-5",{"id":24,"text":2671,"url":24,"identifiers":2672},"Levey, 2012, Chronic kidney disease., Lancet, 379, 165, 10.1016\u002FS0140-6736(11)60178-5",{"doi":2673},"10.1016\u002FS0140-6736(11)60178-5",{"id":24,"text":2675,"url":24,"identifiers":2676},"Vaziri, 2012, Effect of uremia on structure and function of immune system., J. Ren. Nutr., 22, 149, 10.1053\u002Fj.jrn.2011.10.020",{"doi":2677},"10.1053\u002Fj.jrn.2011.10.020",{"id":24,"text":2679,"url":24,"identifiers":2680},"Kurts, 2013, The immune system and kidney disease: basic concepts and clinical implications., Nat. Rev. Immunol., 13, 738, 10.1038\u002Fnri3523",{"doi":2681},"10.1038\u002Fnri3523",{"id":24,"text":2683,"url":24,"identifiers":2684},"Kato, 2008, Aspects of immune dysfunction in end-stage renal disease., Clin. J. Am. Soc. Nephrol., 3, 1526, 10.2215\u002FCJN.00950208",{"doi":2685},"10.2215\u002FCJN.00950208",{"id":24,"text":2687,"url":24,"identifiers":2688},"Betjes, 2013, Immune cell dysfunction and inflammation in end-stage renal disease., Nat. Rev. Nephrol., 9, 255, 10.1038\u002Fnrneph.2013.44",{"doi":2689},"10.1038\u002Fnrneph.2013.44",{"id":24,"text":2691,"url":24,"identifiers":2692},"Klose, 2016, Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis., Nat. Immunol., 17, 765, 10.1038\u002Fni.3489",{"doi":2693},"10.1038\u002Fni.3489",{"id":24,"text":2695,"url":24,"identifiers":2696},"Mjösberg, 2016, Human innate lymphoid cells., J. Allergy Clin. Immunol., 138, 1265, 10.1016\u002Fj.jaci.2016.09.009",{"doi":2697},"10.1016\u002Fj.jaci.2016.09.009",{"id":24,"text":2699,"url":24,"identifiers":2700},"Vivier, 2018, Innate lymphoid cells: 10 years on., Cell, 174, 1054, 10.1016\u002Fj.cell.2018.07.017",{"doi":2701},"10.1016\u002Fj.cell.2018.07.017",{"id":24,"text":2703,"url":24,"identifiers":2704},"von Moltke, 2016, Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit., Nature, 529, 221, 10.1038\u002Fnature16161",{"doi":2705},"10.1038\u002Fnature16161",{"id":24,"text":2707,"url":24,"identifiers":2708},"Ricardo-Gonzalez, 2018, Tissue signals imprint ILC2 identity with anticipatory function., Nat. Immunol., 19, 1093, 10.1038\u002Fs41590-018-0201-4",{"doi":2709},"10.1038\u002Fs41590-018-0201-4",{"id":24,"text":2711,"url":24,"identifiers":2712},"Brestoff, 2015, Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity., Nature, 519, 242, 10.1038\u002Fnature14115",{"doi":2713},"10.1038\u002Fnature14115",{"id":24,"text":2715,"url":24,"identifiers":2716},"Koga, 2018, Peripheral PDGFRα+gp38+ mesenchymal cells support the differentiation of fetal liver-derived ILC2., J. Exp. Med., 215, 1609, 10.1084\u002Fjem.20172310",{"doi":2717},"10.1084\u002Fjem.20172310",{"id":24,"text":2719,"url":24,"identifiers":2720},"Cao, 2018, Potentiating tissue-resident type 2 innate lymphoid cells by IL-33 to prevent renal ischemia-reperfusion injury., J. Am. Soc. Nephrol., 29, 961, 10.1681\u002FASN.2017070774",{"doi":2721},"10.1681\u002FASN.2017070774",{"id":24,"text":2723,"url":24,"identifiers":2724},"Kwon, 2013, Innate type 2 immunity is associated with eosinophilic pleural effusion in primary spontaneous pneumothorax., Am. J. Respir. Crit. Care Med., 188, 577, 10.1164\u002Frccm.201302-0295OC",{"doi":2725},"10.1164\u002Frccm.201302-0295OC",{"id":24,"text":2727,"url":24,"identifiers":2728},"Bartemes, 2014, Enhanced innate type 2 immune response in peripheral blood from patients with asthma., J. Allergy Clin. Immunol., 671",{},{"id":24,"text":2730,"url":24,"identifiers":2731},"Poposki, 2017, Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps., Immun. Inflamm. Dis., 5, 233, 10.1002\u002Fiid3.161",{"doi":2732},"10.1002\u002Fiid3.161",{"id":24,"text":2734,"url":24,"identifiers":2735},"Kato, 2019, Group 2 innate lymphoid cells in airway diseases., Chest, 156, 141, 10.1016\u002Fj.chest.2019.04.101",{"doi":2736},"10.1016\u002Fj.chest.2019.04.101",{"id":24,"text":2738,"url":24,"identifiers":2739},"Rak, 2016, IL-33-Dependent group 2 innate lymphoid cells promote cutaneous wound healing., J. Invest. Dermatol., 136, 487, 10.1038\u002FJID.2015.406",{"doi":2740},"10.1038\u002FJID.2015.406",{"id":24,"text":2742,"url":24,"identifiers":2743},"Cao, 2011, IL-25 induces M2 macrophages and reduces renal injury in proteinuric kidney disease., J. Am. Soc. Nephrol., 22, 1229, 10.1681\u002FASN.2010070693",{"doi":2744},"10.1681\u002FASN.2010070693",{"id":24,"text":2746,"url":24,"identifiers":2747},"Riedel, 2017, IL-33-Mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis., J. Am. Soc. Nephrol., 28, 2068, 10.1681\u002FASN.2016080877",{"doi":2748},"10.1681\u002FASN.2016080877",{"id":24,"text":2750,"url":24,"identifiers":2751},"Stremska, 2017, IL233, A novel IL-2 and IL-33 hybrid cytokine, ameliorates renal injury., J. Am. Soc. Nephrol., 28, 2681, 10.1681\u002FASN.2016121272",{"doi":2752},"10.1681\u002FASN.2016121272",{"id":24,"text":2754,"url":24,"identifiers":2755},"Huang, 2015, IL-25 elicits innate lymphoid cells and multipotent progenitor type 2 cells that reduce renal ischemic\u002Freperfusion injury., J. Am. Soc. Nephrol., 26, 2199, 10.1681\u002FASN.2014050479",{"doi":2756},"10.1681\u002FASN.2014050479",{"id":24,"text":2758,"url":24,"identifiers":2759},"Qin, 2013, Expansion of monocytic myeloid-derived suppressor cells dampens T cell function in HIV-1-seropositive individuals., J. Virol., 87, 1477, 10.1128\u002FJVI.01759-12",{"doi":2760},"10.1128\u002FJVI.01759-12",{"id":24,"text":2762,"url":24,"identifiers":2763},"Hazenberg, 2014, Human innate lymphoid cells., Blood, 124, 700, 10.1182\u002Fblood-2013-11-427781",{"doi":2764},"10.1182\u002Fblood-2013-11-427781",{"id":24,"text":2766,"url":24,"identifiers":2767},"Mjösberg, 2011, Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161., Nat. Immunol., 12, 1055, 10.1038\u002Fni.2104",{"doi":2768},"10.1038\u002Fni.2104",{"id":24,"text":2770,"url":24,"identifiers":2771},"Lim, 2017, Systemic human ILC precursors provide a substrate for tissue ILC differentiation., Cell., 1086",{},{"id":24,"text":2773,"url":24,"identifiers":2774},"Rauber, 2017, Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells., Nat. Med., 23, 938, 10.1038\u002Fnm.4373",{"doi":2775},"10.1038\u002Fnm.4373",{"id":24,"text":2777,"url":24,"identifiers":2778},"Bernink, 2013, Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues., Nat. Immunol., 14, 221, 10.1038\u002Fni.2534",{"doi":2779},"10.1038\u002Fni.2534",{"id":24,"text":2781,"url":24,"identifiers":2782},"Milieu Intérieur Consortium, 2018, Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors. [Published erratum appears in 2018 Nat. Immunol. 19: 645.], Nat. Immunol., 19, 302",{},{"id":24,"text":2784,"url":24,"identifiers":2785},"Hochdörfer, 2019, Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells., Eur. J. Immunol., 49, 884, 10.1002\u002Feji.201848006",{"doi":2786},"10.1002\u002Feji.201848006",{"id":24,"text":2788,"url":24,"identifiers":2789},"Bernink, 2019, c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies. [Published erratum appears in 2020 Nat. Immunol. 21: 101.], Nat. Immunol., 20, 992, 10.1038\u002Fs41590-019-0423-0",{"doi":2790},"10.1038\u002Fs41590-019-0423-0",{"id":24,"text":2792,"url":24,"identifiers":2793},"Landwehr-Kenzel, 2018, Ex vivo expanded natural regulatory T cells from patients with end-stage renal disease or kidney transplantation are useful for autologous cell therapy., Kidney Int., 93, 1452, 10.1016\u002Fj.kint.2018.01.021",{"doi":2794},"10.1016\u002Fj.kint.2018.01.021",{"id":24,"text":2796,"url":24,"identifiers":2797},"Pahl, 2010, Effect of end-stage renal disease on B-lymphocyte subpopulations, IL-7, BAFF and BAFF receptor expression., Nephrol. Dial. Transplant., 25, 205, 10.1093\u002Fndt\u002Fgfp397",{"doi":2798},"10.1093\u002Fndt\u002Fgfp397",{"id":24,"text":2800,"url":24,"identifiers":2801},"Lisowska, 2014, Influence of hemodialysis on circulating CD4(low)CD25 (high) regulatory T cells in end-stage renal disease patients., Inflamm. Res., 63, 99, 10.1007\u002Fs00011-013-0679-z",{"doi":2802},"10.1007\u002Fs00011-013-0679-z",{"id":24,"text":2804,"url":24,"identifiers":2805},"Fernández-Fresnedo, 2000, B lymphopenia in uremia is related to an accelerated in vitro apoptosis and dysregulation of Bcl-2., Nephrol. Dial. Transplant., 15, 502, 10.1093\u002Fndt\u002F15.4.502",{"doi":2806},"10.1093\u002Fndt\u002F15.4.502",{"id":24,"text":2808,"url":24,"identifiers":2809},"Kimmel, 1998, Immunologic function and survival in hemodialysis patients., Kidney Int., 54, 236, 10.1046\u002Fj.1523-1755.1998.00981.x",{"doi":2810},"10.1046\u002Fj.1523-1755.1998.00981.x",{"id":24,"text":2812,"url":24,"identifiers":2813},"Mjösberg, 2012, The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells., Immunity, 37, 649, 10.1016\u002Fj.immuni.2012.08.015",{"doi":2814},"10.1016\u002Fj.immuni.2012.08.015",{"id":24,"text":2816,"url":24,"identifiers":2817},"Lei, 2018, ICAM-1 controls development and function of ILC2., J. Exp. Med., 215, 2157, 10.1084\u002Fjem.20172359",{"doi":2818},"10.1084\u002Fjem.20172359",{"id":24,"text":2820,"url":24,"identifiers":2821},"Schiering, 2014, The alarmin IL-33 promotes regulatory T-cell function in the intestine., Nature, 513, 564, 10.1038\u002Fnature13577",{"doi":2822},"10.1038\u002Fnature13577",{"id":24,"text":2824,"url":24,"identifiers":2825},"Xue, 2014, Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells., J. Allergy Clin. Immunol., 133, 1184, 10.1016\u002Fj.jaci.2013.10.056",{"doi":2826},"10.1016\u002Fj.jaci.2013.10.056",{"id":24,"text":2828,"url":24,"identifiers":2829},"Villarino, 2017, Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells., J. Exp. Med., 214, 2999, 10.1084\u002Fjem.20150907",{"doi":2830},"10.1084\u002Fjem.20150907",{"id":24,"text":2832,"url":24,"identifiers":2833},"Maazi, 2015, ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity., Immunity, 42, 538, 10.1016\u002Fj.immuni.2015.02.007",{"doi":2834},"10.1016\u002Fj.immuni.2015.02.007",{"id":24,"text":2836,"url":24,"identifiers":2837},"Cohen, 2010, Cytokine patterns and survival in haemodialysis patients., Nephrol. Dial. Transplant., 25, 1239, 10.1093\u002Fndt\u002Fgfp625",{"doi":2838},"10.1093\u002Fndt\u002Fgfp625",{"id":24,"text":2840,"url":24,"identifiers":2841},"Schindler, 2007, JAK-STAT signaling: from interferons to cytokines., J. Biol. Chem., 282, 20059, 10.1074\u002Fjbc.R700016200",{"doi":2842},"10.1074\u002Fjbc.R700016200",{"id":24,"text":2844,"url":24,"identifiers":2845},"Schindler, 2002, Series introduction. JAK-STAT signaling in human disease., J. Clin. Invest., 109, 1133, 10.1172\u002FJCI0215644",{"doi":2846},"10.1172\u002FJCI0215644",{"id":24,"text":2848,"url":24,"identifiers":2849},"Juffroy, 2010, Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK\u002FSTAT5 pathway., J. Virol., 84, 96, 10.1128\u002FJVI.01475-09",{"doi":2850},"10.1128\u002FJVI.01475-09",{"id":24,"text":2852,"url":24,"identifiers":2853},"Freitag, 1978, Impaired parathyroid hormone metabolism in patients with chronic renal failure., N. Engl. J. Med., 298, 29, 10.1056\u002FNEJM197801052980107",{"doi":2854},"10.1056\u002FNEJM197801052980107",{"id":24,"text":2856,"url":24,"identifiers":2857},"Go, 2004, Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization., N. Engl. J. Med., 351, 1296, 10.1056\u002FNEJMoa041031",{"doi":2858},"10.1056\u002FNEJMoa041031",{"id":24,"text":2860,"url":24,"identifiers":2861},"Tentori, 2008, Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and PTH: the Dialysis Outcomes and Practice Patterns Study (DOPPS)., Am. J. Kidney Dis., 52, 519, 10.1053\u002Fj.ajkd.2008.03.020",{"doi":2862},"10.1053\u002Fj.ajkd.2008.03.020",{"id":24,"text":2864,"url":24,"identifiers":2865},"Peralta, 2011, Detection of chronic kidney disease with creatinine, cystatin C, and urine albumin-to-creatinine ratio and association with progression to end-stage renal disease and mortality., JAMA, 305, 1545, 10.1001\u002Fjama.2011.468",{"doi":2866},"10.1001\u002Fjama.2011.468",{"id":24,"text":2868,"url":24,"identifiers":2869},"Juelke, 2016, Differentiation of human innate lymphoid cells (ILCs)., Curr. Opin. Immunol., 38, 75, 10.1016\u002Fj.coi.2015.11.005",{"doi":2870},"10.1016\u002Fj.coi.2015.11.005",{"id":24,"text":2872,"url":24,"identifiers":2873},"Licona-Limón, 2013, TH2, allergy and group 2 innate lymphoid cells. [Published erratum appears in 2014 Nat. Immunol. 15: 109.], Nat. Immunol., 14, 536, 10.1038\u002Fni.2617",{"doi":2874},"10.1038\u002Fni.2617",{"id":24,"text":2876,"url":24,"identifiers":2877},"Oboki, 2010, IL-33 is a crucial amplifier of innate rather than acquired immunity., Proc. Natl. Acad. Sci. USA, 107, 18581, 10.1073\u002Fpnas.1003059107",{"doi":2878},"10.1073\u002Fpnas.1003059107",{"id":24,"text":2880,"url":24,"identifiers":2881},"Yasuda, 2012, Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice., Proc. Natl. Acad. Sci. USA, 109, 3451, 10.1073\u002Fpnas.1201042109",{"doi":2882},"10.1073\u002Fpnas.1201042109",{"id":24,"text":2884,"url":24,"identifiers":2885},"McGinty, 2020, Tuft-cell-derived leukotrienes drive rapid anti-helminth immunity in the small intestine but are dispensable for anti-protist immunity., Immunity., 528",{},{"id":24,"text":2887,"url":24,"identifiers":2888},"Moriyama, 2018, β2-adrenergic receptor-mediated negative regulation of group 2 innate lymphoid cell responses., Science, 359, 1056, 10.1126\u002Fscience.aan4829",{"doi":2889},"10.1126\u002Fscience.aan4829",{"id":24,"text":2891,"url":24,"identifiers":2892},"Klose, 2017, The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation., Nature, 549, 282, 10.1038\u002Fnature23676",{"doi":2893},"10.1038\u002Fnature23676",{"id":24,"text":2895,"url":24,"identifiers":2896},"Cardoso, 2017, Neuronal regulation of type 2 innate lymphoid cells via neuromedin U., Nature, 549, 277, 10.1038\u002Fnature23469",{"doi":2897},"10.1038\u002Fnature23469",{"id":24,"text":2899,"url":24,"identifiers":2900},"Nussbaum, 2013, Type 2 innate lymphoid cells control eosinophil homeostasis., Nature, 502, 245, 10.1038\u002Fnature12526",{"doi":2901},"10.1038\u002Fnature12526",{"id":24,"text":2903,"url":24,"identifiers":2904},"Wallrapp, 2019, Calcitonin gene-related peptide negatively regulates alarmin-driven type 2 innate lymphoid cell responses., Immunity., 709",{},{"id":24,"text":2906,"url":24,"identifiers":2907},"Galle-Treger, 2016, Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity., Nat. Commun., 7, 13202, 10.1038\u002Fncomms13202",{"doi":2908},"10.1038\u002Fncomms13202",{"id":24,"text":2910,"url":24,"identifiers":2911},"Chu, 2020, Neuro-immune interactions in the tissues., Immunity, 52, 464, 10.1016\u002Fj.immuni.2020.02.017",{"doi":2912},"10.1016\u002Fj.immuni.2020.02.017",{"id":24,"text":2914,"url":24,"identifiers":2915},"Moriyama, 2019, Neuronal regulation of group 2 innate lymphoid cells and type 2 inflammation., Adv. Immunol., 143, 1, 10.1016\u002Fbs.ai.2019.08.001",{"doi":2916},"10.1016\u002Fbs.ai.2019.08.001",{"id":24,"text":2918,"url":24,"identifiers":2919},"Rangarajan, 2020, COX-2-derived prostaglandins as mediators of the deleterious effects of nicotine in chronic kidney disease., Am. J. Physiol. Renal Physiol., 318, F475, 10.1152\u002Fajprenal.00407.2019",{"doi":2920},"10.1152\u002Fajprenal.00407.2019",{"id":2922,"createTime":2923,"updateTime":2924,"relativeEntities":2925,"slug":2926,"properties":2927,"entityType":295,"verifyStatus":296,"verifyTime":2941,"verifyNote":297,"languages":2942,"translateLanguages":24,"viewCount":25,"primaryUrl":2943,"fullTextUrl":24,"authors":2944,"publicationType":423,"publisherRelationship":3045,"citationCount":3099,"citationInfo":3100,"publishDate":3103,"publishYear":3101,"citationAnalyzeStatus":1855,"lastCitationAnalyze":3104,"indexDatabases":3105,"openAccess":24,"references":3106,"isForceReanalyzing":615},"addf0a11-ba9b-417f-815f-a17380c071bc","2024-10-07T09:16:00.420+00:00","2026-07-20T20:42:31.773+00:00",[],"Activation-of-the-Lectin-Complement-Pathway-by-H-Ficolin-Hakata-Antigen-",{"mag":2928,"gsPaper":2930,"openalex":2931,"abstract":2933,"title":2935,"pm":2937,"doi":2939},{"VOID":2929},"1923930491",{"VOID":1719},{"VOID":2932},"W1923930491",{"EN":2934},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins named L-ficolin\u002FP35 and H-ficolin (Hakata Ag), both of which have lectin activity. We recently demonstrated that L-ficolin\u002FP35 is associated with mannose-binding lectin (MBL)-associated serine proteases (MASP) 1 and 2 and small MBL-associated protein (sMAP), and that the complex activates the lectin pathway. In this study, we report the characterization of H-ficolin in terms of its ability to activate complement. Western blotting analysis showed the presence of MASP-1, MASP-2, MASP-3, and sMAP in H-ficolin preparations isolated from Cohn Fraction III. The MASPs in the preparations had proteolytic activities against C4, C2, and C3 in the fluid phase. When H-ficolin preparations were bound to anti-H-ficolin Ab which had been coated on ELISA plates, they activated C4, although no C4 activation was noted when anti-MBL and anti-L-ficolin\u002FP35 were used. H-ficolin binds to PSA, a polysaccharide produced by Aerococcus viridans. C4 was activated by H-ficolin preparations bound to PSA which had been coated on ELISA plates. These results indicate that H-ficolin is a second ficolin which is associated with MASPs and sMAP, and which activates the lectin pathway.\u003C\u002Fjats:p>",{"EN":2936},"Activation of the Lectin Complement Pathway by H-Ficolin (Hakata Antigen)",{"VOID":2938},"11907111",{"VOID":2940},"10.4049\u002Fjimmunol.168.7.3502","2024-10-07T09:16:00.419+00:00",[299],"https:\u002F\u002Fjournals.aai.org\u002Fjimmunol\u002Farticle\u002F168\u002F7\u002F3502\u002F34863\u002FActivation-of-the-Lectin-Complement-Pathway-by-H",[2945,2964,2979,2996,3013,3028],{"id":2946,"sortIndex":25,"researcher":24,"roles":2947,"affiliations":2948,"properties":2957,"displayName":2961,"givenName":24,"familyName":24},"f4b9a156-cb48-43ca-b881-88f8041ed299",[],[2949],{"id":2950,"sortIndex":25,"affiliation":2951,"properties":24},"16edd029-6817-4a18-988e-f874f5e4601b",{"id":2950,"createTime":24,"updateTime":24,"relativeEntities":2952,"slug":24,"properties":2953,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2956,"statistic":24},[],{"title":2954},{"VI":2955},"Department of Biochemistry, Fukushima Medical University School of Medicine, Fukushima, Japan",[],{"orcid":2958,"title":2960,"openalex":2962},{"VOID":2959},"https:\u002F\u002Forcid.org\u002F0000-0002-0351-0562",{"EN":2961},"Misao Matsushita",{"VOID":2963},"A5009306852",{"id":2965,"sortIndex":110,"researcher":24,"roles":2966,"affiliations":2967,"properties":2974,"displayName":2976,"givenName":24,"familyName":24},"24f68d60-7a47-43f1-b211-4c28cb127755",[],[2968],{"id":2950,"sortIndex":25,"affiliation":2969,"properties":24},{"id":2950,"createTime":24,"updateTime":24,"relativeEntities":2970,"slug":24,"properties":2971,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2973,"statistic":24},[],{"title":2972},{"VI":2955},[],{"title":2975,"openalex":2977},{"EN":2976},"Mikio Kuraya",{"VOID":2978},"A5025052429",{"id":2980,"sortIndex":109,"researcher":24,"roles":2981,"affiliations":2982,"properties":2991,"displayName":2993,"givenName":24,"familyName":24},"2d5f9d34-5873-4d22-ad4a-eecee118866b",[],[2983],{"id":2984,"sortIndex":25,"affiliation":2985,"properties":24},"de59d778-2164-46ff-818e-d59ed4704749",{"id":2984,"createTime":24,"updateTime":24,"relativeEntities":2986,"slug":24,"properties":2987,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2990,"statistic":24},[],{"title":2988},{"EN":2989},"†Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; and",[],{"title":2992,"openalex":2994},{"EN":2993},"Naotaka Hamasaki",{"VOID":2995},"A5048838957",{"id":2997,"sortIndex":111,"researcher":24,"roles":2998,"affiliations":2999,"properties":3008,"displayName":3010,"givenName":24,"familyName":24},"e3ee6be3-cd31-4bb3-b504-7e491053f384",[],[3000],{"id":3001,"sortIndex":25,"affiliation":3002,"properties":24},"51f05e25-d0a3-479a-b918-0fbf4c807c43",{"id":3001,"createTime":24,"updateTime":24,"relativeEntities":3003,"slug":24,"properties":3004,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":3007,"statistic":24},[],{"title":3005},{"EN":3006},"‡Fukuoka Red Cross Blood Center, Chikushino, Japan",[],{"title":3009,"openalex":3011},{"EN":3010},"Mitsushi Tsujimura",{"VOID":3012},"A5051340469",{"id":3014,"sortIndex":112,"researcher":24,"roles":3015,"affiliations":3016,"properties":3023,"displayName":3025,"givenName":24,"familyName":24},"562dfb70-0eb1-47a1-b1d9-5e99c6735294",[],[3017],{"id":3001,"sortIndex":25,"affiliation":3018,"properties":24},{"id":3001,"createTime":24,"updateTime":24,"relativeEntities":3019,"slug":24,"properties":3020,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":3022,"statistic":24},[],{"title":3021},{"EN":3006},[],{"title":3024,"openalex":3026},{"EN":3025},"Hiroshi Shiraki",{"VOID":3027},"A5020327879",{"id":3029,"sortIndex":113,"researcher":24,"roles":3030,"affiliations":3031,"properties":3038,"displayName":3042,"givenName":24,"familyName":24},"c77c18bd-fa7f-45a7-b419-6bb965f9935d",[],[3032],{"id":2950,"sortIndex":25,"affiliation":3033,"properties":24},{"id":2950,"createTime":24,"updateTime":24,"relativeEntities":3034,"slug":24,"properties":3035,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":3037,"statistic":24},[],{"title":3036},{"VI":2955},[],{"orcid":3039,"title":3041,"openalex":3043},{"VOID":3040},"https:\u002F\u002Forcid.org\u002F0000-0001-9834-8985",{"EN":3042},"Teizo Fujita",{"VOID":3044},"A5103076313",{"url":24,"publisher":3046,"properties":3093},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":3047,"slug":10,"properties":3048,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":3053,"manageAffiliations":3062,"indexDatabases":3073,"url":90,"thumbnailPath":24,"statistic":3088,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":3049,"eissn":3050,"issn":3051,"title":3052},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[3054,3058],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":3055,"label":3056,"description":3057,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":3059,"label":3060,"description":3061,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[3063,3068],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":3064,"slug":24,"properties":3065,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":3067,"statistic":24},[],{"title":3066},{"EN":45},[],{"id":48,"createTime":24,"updateTime":24,"relativeEntities":3069,"slug":24,"properties":3070,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":3072,"statistic":24},[],{"title":3071},{"EN":52},[],[3074,3081],{"id":56,"indexDatabase":3075,"url":69,"indexYears":24,"academicFieldIds":3080,"indexDatabaseRanking":24},{"id":58,"createTime":24,"updateTime":24,"relativeEntities":3076,"label":3077,"description":3078,"key":65,"publicationTags":3079,"standard":24},[],{"EN":61,"VI":61},{"EN":63,"VI":64},[67,68],[71],{"id":73,"indexDatabase":3082,"url":84,"indexYears":85,"academicFieldIds":3087,"indexDatabaseRanking":89},{"id":75,"createTime":24,"updateTime":24,"relativeEntities":3083,"label":3084,"description":3085,"key":81,"publicationTags":3086,"standard":24},[],{"EN":78,"VI":78},{"EN":78,"VI":80},[83],[87,88],{"impactFactor":25,"impactFactorByYear":3089,"i10Index":105,"i10IndexLast5Year":106,"totalPublication":107,"totalPublicationByYear":3090,"totalCitation":145,"totalCitationByYear":3091,"totalCitationPerPublication":210,"totalCitationPerPublicationByYear":3092,"hindexLast5Year":208,"hindex":208},{"2012":93,"2013":94,"2014":95,"2015":96,"2016":97,"2017":98,"2018":99,"2019":100,"2020":101,"2021":102,"2022":103,"2023":104},{"1938":109,"1940":110,"1946":109,"1954":110,"1956":109,"1958":110,"1959":110,"1963":110,"1965":111,"1966":112,"1967":110,"1968":112,"1969":112,"1970":111,"1971":112,"1972":113,"1973":112,"1974":111,"1975":114,"1976":115,"1977":116,"1978":115,"1979":106,"1980":117,"1981":114,"1982":115,"1983":118,"1984":106,"1985":119,"1986":120,"1987":118,"1988":121,"1989":117,"1990":122,"1991":123,"1992":124,"1993":125,"1994":126,"1995":127,"1996":128,"1997":129,"1998":130,"1999":131,"2000":132,"2001":133,"2002":134,"2003":135,"2004":135,"2005":136,"2006":137,"2007":138,"2008":139,"2009":128,"2010":140,"2011":141,"2012":128,"2013":142,"2014":121,"2015":119,"2016":120,"2017":102,"2018":143,"2020":102,"2021":144,"2022":110},{"1938":147,"1940":148,"1946":124,"1954":149,"1956":150,"1958":151,"1959":152,"1963":153,"1965":154,"1966":155,"1967":156,"1968":157,"1969":158,"1970":159,"1971":160,"1972":161,"1973":162,"1974":163,"1975":164,"1976":165,"1977":166,"1978":167,"1979":168,"1980":169,"1981":170,"1982":171,"1983":172,"1984":173,"1985":174,"1986":175,"1987":176,"1988":177,"1989":178,"1990":179,"1991":180,"1992":181,"1993":182,"1994":183,"1995":184,"1996":185,"1997":186,"1998":187,"1999":188,"2000":189,"2001":190,"2002":191,"2003":192,"2004":193,"2005":194,"2006":195,"2007":196,"2008":197,"2009":198,"2010":199,"2011":200,"2012":201,"2013":202,"2014":203,"2015":204,"2016":205,"2017":206,"2018":207,"2020":208,"2021":209,"2022":109},{"1938":212,"1940":148,"1946":213,"1954":149,"1956":214,"1958":151,"1959":152,"1963":153,"1965":215,"1966":216,"1967":156,"1968":217,"1969":218,"1970":219,"1971":220,"1972":221,"1973":222,"1974":223,"1975":224,"1976":225,"1977":226,"1978":227,"1979":228,"1980":229,"1981":230,"1982":231,"1983":232,"1984":233,"1985":234,"1986":235,"1987":236,"1988":237,"1989":238,"1990":239,"1991":240,"1992":241,"1993":242,"1994":243,"1995":244,"1996":245,"1997":246,"1998":247,"1999":248,"2000":249,"2001":250,"2002":251,"2003":252,"2004":253,"2005":254,"2006":255,"2007":256,"2008":257,"2009":258,"2010":259,"2011":260,"2012":261,"2013":262,"2014":263,"2015":264,"2016":265,"2017":266,"2018":267,"2020":268,"2021":269,"2022":109},{"issue":3094,"pages":3095,"volume":3097},{"VOID":1340},{"VOID":3096},"3502-3506",{"VOID":3098},"168",191,{"total":3099,"publishYear":3101,"statisticByYear":3102},2002,{"2012":106,"2013":144,"2014":112,"2015":112,"2016":143,"2017":113,"2018":112,"2019":112,"2020":111,"2021":112,"2022":808,"2023":111,"2024":110},"2002-04-01","2026-07-20T20:42:31.772+00:00",[67,89],[3107,3111,3115,3119,3123,3127,3131,3135,3139,3143,3147,3151,3155,3159,3163,3166,3170,3174,3178,3182,3186,3190,3194,3198,3202,3206,3210,3214,3218,3222,3226,3230,3234,3238],{"id":24,"text":3108,"url":24,"identifiers":3109},"Matsushita, M., T. Fujita. 2001. Ficolins and the lectin complement pathway. Immunol. Rev. 180: 78",{"doi":3110},"10.1034\u002Fj.1600-065X.2001.1800107.x",{"id":24,"text":3112,"url":24,"identifiers":3113},"Ichijo, H., L. Ronnstrand, K. Miyagawa, H. Ohashi, C. H. Heldin, K. Miyazono. 1991. Purification of transforming growth factor-β1 binding proteins from porcine uterus membranes. J. Biol. Chem. 266: 22459",{"doi":3114},"10.1016\u002FS0021-9258(18)54594-4",{"id":24,"text":3116,"url":24,"identifiers":3117},"Ichijo, H., U. Hellman, C. Wernstedt, L. J. Gonez, L. Claesson-Welsh, C. H. Helden, K. Miyazono. 1993. Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains. J. Biol. Chem. 268: 14505",{"doi":3118},"10.1016\u002FS0021-9258(19)85267-5",{"id":24,"text":3120,"url":24,"identifiers":3121},"Matsushita, M., Y. Endo, S. Taira, Y. Sato, T. Fujita, N. Ichikawa, M. Nakata, T. Mizuochi. 1996. A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin. J. Biol. Chem. 271: 2448",{"doi":3122},"10.1074\u002Fjbc.271.5.2448",{"id":24,"text":3124,"url":24,"identifiers":3125},"Sugimoto, R., Y. Yae, M. Akaiwa, S. Kitajima, Y. Shibata, H. Sato, J. Hirata, K. Okochi, K. Izuhara, N. Hamasaki. 1998. Cloning and characterization of the Hakata antigen, a member of the ficolin\u002Fopsonin p35 lectin family. J. Biol. Chem. 273: 20721",{"doi":3126},"10.1074\u002Fjbc.273.33.20721",{"id":24,"text":3128,"url":24,"identifiers":3129},"Teh, C., Y. Le, S. H. Lee, J. Lu. 2000. M-ficolin is expressed on monocytes and is a lectin binding to N-acetyl-d-glucosamine and mediates monocyte adhesion and phagocytosis of Escherichia coli. Immunology 101: 225",{"doi":3130},"10.1046\u002Fj.1365-2567.2000.00099.x",{"id":24,"text":3132,"url":24,"identifiers":3133},"Ohashi, T., H. P. Erickson. 1997. Two oligomeric forms of plasma ficolin have differential lectin activity. J. Biol. Chem. 272: 14220",{"doi":3134},"10.1074\u002Fjbc.272.22.14220",{"id":24,"text":3136,"url":24,"identifiers":3137},"Fujimori, Y., S. Harumiya, Y. Fukumoto, Y. Miura, K. Yagasaki, H. Tachikawa, D. Fujimoto. 1998. Molecular cloning and characterization of mouse ficolin-A. Biochim. Biophys. Acta 244: 796",{"doi":3138},"10.1006\u002Fbbrc.1998.8344",{"id":24,"text":3140,"url":24,"identifiers":3141},"Kenjo, A., M. Takahashi, M. Matsushita, Y. Endo, M. Nakata, T. Mizuochi, T. Fujita. 2001. Cloning and characterization of novel ficolins from the solitary ascidian, Halocynthia roretzi. J. Biol. Chem. 276: 19959",{"doi":3142},"10.1074\u002Fjbc.M011723200",{"id":24,"text":3144,"url":24,"identifiers":3145},"Le, Y., S. H. Lee, O. L. Kon, J. Lu. 1998. Human L-ficolin: plasma levels, sugar specificity, and assignment of its lectin activity to the fibrinogen-like (FBG) domain. FEBS Lett. 425: 367",{"doi":3146},"10.1016\u002FS0014-5793(98)00267-1",{"id":24,"text":3148,"url":24,"identifiers":3149},"Endo, Y., Y. Sato, M. Matsushita, T. Fujita. 1996. Cloning and characterization of the human lectin P35 gene and its related gene. Genomics 36: 515",{"doi":3150},"10.1006\u002Fgeno.1996.0497",{"id":24,"text":3152,"url":24,"identifiers":3153},"Lu, J., P. N. Tay, O. L. Kon, K. B. M. Reid. 1996. Human ficolin: cDNA cloning, demonstration of peripheral blood leucocytes as the major site of synthesis and assignment of the gene to chromosome 9. Biochem. J. 313: 473",{"doi":3154},"10.1042\u002Fbj3130473",{"id":24,"text":3156,"url":24,"identifiers":3157},"Harumiya, S., A. Omori, T. Sugiura, Y. Fukumoto, H. Tachikawa, D. Fujimoto. 1995. EBP-37, a new elastin-binding protein in human plasma: structural similarity to ficolins, tranforming growth factor-β1-binding proteins. J. Biochem. 117: 1029",{"doi":3158},"10.1093\u002Foxfordjournals.jbchem.a124802",{"id":24,"text":3160,"url":24,"identifiers":3161},"Edgar, P. F.. 1995. Hucolin, a new corticosteroid-binding protein from human plasma with structural similarities to ficolins, transforming growth factor-β1-binding proteins. FEBS Lett. 375: 159",{"doi":3162},"10.1016\u002F0014-5793(95)01205-S",{"id":24,"text":3164,"url":24,"identifiers":3165},"Inaba, S., K. Okochi. 1978. On a new precipitating antibody against normal human serum found in two patients with SLE. Igaku no Ayumi 1107: 690",{},{"id":24,"text":3167,"url":24,"identifiers":3168},"Yae, Y., S. Inaba, H. Sato, K. Okochi, F. Tokunaga, S. Iwanaga. 1991. Isolation and characterization of a thermolabile β-2 macroglycoprotein (“thermolabile substance” or “Hakata antigen”) detected by precipitating (auto) antibody in sera of patients with systemic lupus erythematosus. Biochim. Biophys. Acta 1078: 369",{"doi":3169},"10.1016\u002F0167-4838(91)90158-V",{"id":24,"text":3171,"url":24,"identifiers":3172},"Akaiwa, M., Y. Yae, R. Sugimoto, S. O. Suzuki, T. Iwaki, K. Izuhara, N. Hamasaki. 1999. Hakata antigen, a new member of the ficolin\u002Fopsonin p35 family, is a novel human lectin secreted into bronchus\u002Falveolus and bile. J. Histochem. Cytochem. 47: 777",{"doi":3173},"10.1177\u002F002215549904700607",{"id":24,"text":3175,"url":24,"identifiers":3176},"Epstein, J., Q. Eichbaum, S. Sheriff, R. A. B. Ezekowitz. 1996. The collectins in innate immunity. Curr. Opin. Immunol. 8: 29",{"doi":3177},"10.1016\u002FS0952-7915(96)80101-4",{"id":24,"text":3179,"url":24,"identifiers":3180},"Turner, M. W.. 1996. Mannose-binding lectin: the pluripotent molecule of the innate immune system. Immunol. Today 17: 532",{"doi":3181},"10.1016\u002F0167-5699(96)10062-1",{"id":24,"text":3183,"url":24,"identifiers":3184},"Matsushita, M., Y. Endo, M. Nonaka, T. Fujita. 1998. Complement-related serine proteases in tunicates and vertebrates. Curr. Opin. Immunol. 10: 29",{"doi":3185},"10.1016\u002FS0952-7915(98)80027-7",{"id":24,"text":3187,"url":24,"identifiers":3188},"Matsushita, M., T. Fujita. 1992. Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease. J. Exp. Med. 176: 1497",{"doi":3189},"10.1084\u002Fjem.176.6.1497",{"id":24,"text":3191,"url":24,"identifiers":3192},"Sato, T., Y. Endo, M. Matsushita, T. Fujita. 1994. Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein. Int. Immunol. 6: 665",{"doi":3193},"10.1093\u002Fintimm\u002F6.4.665",{"id":24,"text":3195,"url":24,"identifiers":3196},"Takada, F., H. Takayama, H. Hatsuse, M. Kawakami. 1994. A new member of the C1s family of component protein found in a bactericidal factor, Ra-reactive factor, in human serum. Biochem. Biophys. Res. Commun. 196: 1003",{"doi":3197},"10.1006\u002Fbbrc.1993.2349",{"id":24,"text":3199,"url":24,"identifiers":3200},"Thiel, S., T. Vorup-Jensen, C. M. Stover, W. Schwaeble, S. B. Laursen, K. Poulsen, A. C. Willis, P. Eggleton, S. Hansen, U. Holmskov, K. B. M. Reid, J. C. Jensenius. 1997. A second serine protease associated with mannan-binding lectin that activates complement. Nature 386: 506",{"doi":3201},"10.1038\u002F386506a0",{"id":24,"text":3203,"url":24,"identifiers":3204},"Dahl, M. R., S. Thiel, M. Matsushita, T. Fujita, A. C. Willis, T. Christensen, T. Vorup-Jensen, J. C. Jensenius. 2001. MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway. Immunity 15: 127",{"doi":3205},"10.1016\u002FS1074-7613(01)00161-3",{"id":24,"text":3207,"url":24,"identifiers":3208},"Takahashi, M., Y. Endo, T. Fujita, M. Matsushita. 1999. A truncated form of mannose-binding lectin-associated serine protease (MASP)-2 expressed by alternative polyadenylation is a component of the lectin complement pathway. Int. Immunol. 11: 859",{"doi":3209},"10.1093\u002Fintimm\u002F11.5.859",{"id":24,"text":3211,"url":24,"identifiers":3212},"Stover, C. D., S. Thiel, M. Thelen, N. J. Lynch, T. Vorup-Jensen, J. C. Jensenius, W. J. Schwaeble. 1999. Two constituents of the initiation complex of the mannan-binding lectin activation pathway of the complement are encoded by a single structural gene. J. Immunol. 162: 3481",{"doi":3213},"10.4049\u002Fjimmunol.162.6.3481",{"id":24,"text":3215,"url":24,"identifiers":3216},"Matsushita, M., S. Thiel, J. C. Jensenius, I. Terai, T. Fujita. 2000. Proteolytic activities of two types of mannose-binding lectin-associated serine protease. J. Immunol. 165: 2637",{"doi":3217},"10.4049\u002Fjimmunol.165.5.2637",{"id":24,"text":3219,"url":24,"identifiers":3220},"Vorup-Jensen, T., S. V. Petersen, A. G. Hansen, K. Poulsen, W. Schwaeble, R. B. Sim, K. B. Reid, S. J. Davis, S. Thiel, J. C. Jensenius. 2000. Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2. J. Immunol. 165: 2093",{"doi":3221},"10.4049\u002Fjimmunol.165.4.2093",{"id":24,"text":3223,"url":24,"identifiers":3224},"Matsushita, M., Y. Endo, T. Fujita. 2000. Complement-activating complex of ficolin and mannose-binding lectin-associated serine protease. J. Immunol. 164: 2281",{"doi":3225},"10.4049\u002Fjimmunol.164.5.2281",{"id":24,"text":3227,"url":24,"identifiers":3228},"Kilpatrick, D. C., T. Fujita, M. Matsushita. 1999. P35, an opsonic lectin of the ficolin family, in human blood from neonates, normal adults, and recurrent miscarriage patients. Immunol. Lett. 67: 109",{"doi":3229},"10.1016\u002FS0165-2478(98)00147-3",{"id":24,"text":3231,"url":24,"identifiers":3232},"Tsujimura, M., C. Ishida, Y. Sagara, T. Miyazaki, K. Murakami, H. Shiraki, K. Okochi, Y. Maeda. 2001. Detection of serum thermolabile β-2 macroglycoprotein (Hakata antigen) by enzyme-linked immunosorbent assay using polysaccharide produced by Aerococcus viridans. Clin. Diagn. Lab Immunol. 8: 454",{"doi":3233},"10.1128\u002FCDLI.8.2.454-459.2001",{"id":24,"text":3235,"url":24,"identifiers":3236},"Matsushita, M., R. A. B. Ezekowitz, T. Fujita. 1995. The Gly-54→Asp allelic form of human mannose-binding protein (MBP) fails to bind MBP-associated serine protease. Biochem. J. 311: 1021",{"doi":3237},"10.1042\u002Fbj3111021",{"id":24,"text":3239,"url":24,"identifiers":3240},"Thiel, S., S. V. Petersen, T. Vorup-Jensen, M. Matsushita, T. Fujita, C. M. Stover, W. J. Schwaeble, J. C. Jensenius. 2000. Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19. J. Immunol. 165: 878",{"doi":3241},"10.4049\u002Fjimmunol.165.2.878",{"id":3243,"createTime":3244,"updateTime":3245,"relativeEntities":3246,"slug":3247,"properties":3248,"entityType":295,"verifyStatus":296,"verifyTime":3244,"verifyNote":297,"languages":3263,"translateLanguages":24,"viewCount":25,"primaryUrl":3264,"fullTextUrl":24,"authors":3265,"publicationType":423,"publisherRelationship":3340,"citationCount":3395,"citationInfo":3396,"publishDate":3399,"publishYear":3397,"citationAnalyzeStatus":23,"lastCitationAnalyze":3400,"indexDatabases":3401,"openAccess":24,"references":3402,"isForceReanalyzing":615},"d2c50609-38ac-4b40-8132-ccf78fc8258f","2024-10-13T18:29:47.261+00:00","2026-07-20T12:58:04.956+00:00",[],"Murine-Cytomegalovirus-Infection-Down-Regulates-MHC-Class-II-Expression-on-Macrophages-by-Induction-of-IL-10",{"mag":3249,"gsPaper":3251,"openalex":3253,"abstract":3255,"title":3257,"pm":3259,"doi":3261},{"VOID":3250},"1777264516",{"VOID":3252},"[\"13239860816656990737\"]",{"VOID":3254},"W1777264516",{"EN":3256},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:p>Herpesviruses utilize many strategies for weakening the host immune response. For CMV, this includes avoidance of NK clearance and inhibition of MHC class I and class II presentation pathways. In this study, we report that mouse CMV (MCMV) specifically causes a premature and transient activation of host IL-10 very early in the course of infection, resulting in a dramatic and selective reduction in MHC class II surface expression. The expression of IL-10 is normally late in the immune response to a pathogen, serving to dampen the response by suppression of the production of inflammatory cytokines. In infection of macrophages, we show that MCMV induces the production of IL-10, leading to an early and selective reduction in the expression of MHC class II on the surface of the cells. Inhibition of MHC class II expression was not observed in the presence of neutralizing Abs to IL-10 or in macrophages from IL-10-deficient mice. Moreover, MCMV-infected IL-10-deficient mice developed an early and significantly more robust macrophage MHC class II induction than normal mice. Altogether, our results demonstrate that viral induction of an IL-10 autocrine pathway plays an essential early role in selectively reducing MHC class II expression on the surface of APC prior to stimulation by IFN-γ.\u003C\u002Fjats:p>",{"EN":3258},"Murine Cytomegalovirus Infection Down-Regulates MHC Class II Expression on Macrophages by Induction of IL-10",{"VOID":3260},"10352288",{"VOID":3262},"10.4049\u002Fjimmunol.162.11.6701",[299],"https:\u002F\u002Fjournals.aai.org\u002Fjimmunol\u002Farticle\u002F162\u002F11\u002F6701\u002F69323\u002FMurine-Cytomegalovirus-Infection-Down-Regulates",[3266,3283,3300,3315],{"id":3267,"sortIndex":25,"researcher":24,"roles":3268,"affiliations":3269,"properties":3278,"displayName":3280,"givenName":24,"familyName":24},"ff893118-21f6-422b-81ad-82e898caaf6e",[],[3270],{"id":3271,"sortIndex":25,"affiliation":3272,"properties":24},"dbaf60c2-2036-4287-9340-5cde31017aaa",{"id":3271,"createTime":24,"updateTime":24,"relativeEntities":3273,"slug":24,"properties":3274,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":3277,"statistic":24},[],{"title":3275},{"VI":3276},"Immunology, and",[],{"title":3279,"openalex":3281},{"EN":3280},"Stella Redpath",{"VOID":3282},"A5062821916",{"id":3284,"sortIndex":110,"researcher":24,"roles":3285,"affiliations":3286,"properties":3293,"displayName":3297,"givenName":24,"familyName":24},"a50a6e5b-a127-415c-8038-e8e316918122",[],[3287],{"id":3271,"sortIndex":25,"affiliation":3288,"properties":24},{"id":3271,"createTime":24,"updateTime":24,"relativeEntities":3289,"slug":24,"properties":3290,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":3292,"statistic":24},[],{"title":3291},{"VI":3276},[],{"orcid":3294,"title":3296,"openalex":3298},{"VOID":3295},"https:\u002F\u002Forcid.org\u002F0000-0002-5792-1164",{"EN":3297},"Ana Angulo",{"VOID":3299},"A5002148348",{"id":3301,"sortIndex":109,"researcher":24,"roles":3302,"affiliations":3303,"properties":3310,"displayName":971,"givenName":24,"familyName":24},"2ac8f39b-01c4-42fb-bbb0-9e4f45f72581",[],[3304],{"id":3271,"sortIndex":25,"affiliation":3305,"properties":24},{"id":3271,"createTime":24,"updateTime":24,"relativeEntities":3306,"slug":24,"properties":3307,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":3309,"statistic":24},[],{"title":3308},{"VI":3276},[],{"orcid":3311,"title":3312,"gsAuthor":3313,"openalex":3314},{"VOID":969},{"EN":971},{"VOID":973},{"VOID":975},{"id":3316,"sortIndex":111,"researcher":24,"roles":3317,"affiliations":3318,"properties":3333,"displayName":3337,"givenName":24,"familyName":24},"eaf0cef7-33ab-474a-b357-fe3a4207d6ac",[],[3319,3325],{"id":3271,"sortIndex":25,"affiliation":3320,"properties":24},{"id":3271,"createTime":24,"updateTime":24,"relativeEntities":3321,"slug":24,"properties":3322,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":3324,"statistic":24},[],{"title":3323},{"VI":3276},[],{"id":3326,"sortIndex":110,"affiliation":3327,"properties":24},"ebf3cfb4-a5c2-40f9-a987-61f895a24b45",{"id":3326,"createTime":24,"updateTime":24,"relativeEntities":3328,"slug":24,"properties":3329,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":3332,"statistic":24},[],{"title":3330},{"EN":3331},"†Molecular Biology, Division of Virology, The Scripps Research Institute, La Jolla, CA 92037",[],{"orcid":3334,"title":3336,"openalex":3338},{"VOID":3335},"https:\u002F\u002Forcid.org\u002F0000-0003-0035-2228",{"EN":3337},"Peter Ghazal",{"VOID":3339},"A5065696246",{"url":24,"publisher":3341,"properties":3388},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":3342,"slug":10,"properties":3343,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":3348,"manageAffiliations":3357,"indexDatabases":3368,"url":90,"thumbnailPath":24,"statistic":3383,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":3344,"eissn":3345,"issn":3346,"title":3347},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[3349,3353],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":3350,"label":3351,"description":3352,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":3354,"label":3355,"description":3356,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[3358,3363],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":3359,"slug":24,"properties":3360,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":3362,"statistic":24},[],{"title":3361},{"EN":45},[],{"id":48,"createTime":24,"updateTime":24,"relativeEntities":3364,"slug":24,"properties":3365,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":3367,"statistic":24},[],{"title":3366},{"EN":52},[],[3369,3376],{"id":56,"indexDatabase":3370,"url":69,"indexYears":24,"academicFieldIds":3375,"indexDatabaseRanking":24},{"id":58,"createTime":24,"updateTime":24,"relativeEntities":3371,"label":3372,"description":3373,"key":65,"publicationTags":3374,"standard":24},[],{"EN":61,"VI":61},{"EN":63,"VI":64},[67,68],[71],{"id":73,"indexDatabase":3377,"url":84,"indexYears":85,"academicFieldIds":3382,"indexDatabaseRanking":89},{"id":75,"createTime":24,"updateTime":24,"relativeEntities":3378,"label":3379,"description":3380,"key":81,"publicationTags":3381,"standard":24},[],{"EN":78,"VI":78},{"EN":78,"VI":80},[83],[87,88],{"impactFactor":25,"impactFactorByYear":3384,"i10Index":105,"i10IndexLast5Year":106,"totalPublication":107,"totalPublicationByYear":3385,"totalCitation":145,"totalCitationByYear":3386,"totalCitationPerPublication":210,"totalCitationPerPublicationByYear":3387,"hindexLast5Year":208,"hindex":208},{"2012":93,"2013":94,"2014":95,"2015":96,"2016":97,"2017":98,"2018":99,"2019":100,"2020":101,"2021":102,"2022":103,"2023":104},{"1938":109,"1940":110,"1946":109,"1954":110,"1956":109,"1958":110,"1959":110,"1963":110,"1965":111,"1966":112,"1967":110,"1968":112,"1969":112,"1970":111,"1971":112,"1972":113,"1973":112,"1974":111,"1975":114,"1976":115,"1977":116,"1978":115,"1979":106,"1980":117,"1981":114,"1982":115,"1983":118,"1984":106,"1985":119,"1986":120,"1987":118,"1988":121,"1989":117,"1990":122,"1991":123,"1992":124,"1993":125,"1994":126,"1995":127,"1996":128,"1997":129,"1998":130,"1999":131,"2000":132,"2001":133,"2002":134,"2003":135,"2004":135,"2005":136,"2006":137,"2007":138,"2008":139,"2009":128,"2010":140,"2011":141,"2012":128,"2013":142,"2014":121,"2015":119,"2016":120,"2017":102,"2018":143,"2020":102,"2021":144,"2022":110},{"1938":147,"1940":148,"1946":124,"1954":149,"1956":150,"1958":151,"1959":152,"1963":153,"1965":154,"1966":155,"1967":156,"1968":157,"1969":158,"1970":159,"1971":160,"1972":161,"1973":162,"1974":163,"1975":164,"1976":165,"1977":166,"1978":167,"1979":168,"1980":169,"1981":170,"1982":171,"1983":172,"1984":173,"1985":174,"1986":175,"1987":176,"1988":177,"1989":178,"1990":179,"1991":180,"1992":181,"1993":182,"1994":183,"1995":184,"1996":185,"1997":186,"1998":187,"1999":188,"2000":189,"2001":190,"2002":191,"2003":192,"2004":193,"2005":194,"2006":195,"2007":196,"2008":197,"2009":198,"2010":199,"2011":200,"2012":201,"2013":202,"2014":203,"2015":204,"2016":205,"2017":206,"2018":207,"2020":208,"2021":209,"2022":109},{"1938":212,"1940":148,"1946":213,"1954":149,"1956":214,"1958":151,"1959":152,"1963":153,"1965":215,"1966":216,"1967":156,"1968":217,"1969":218,"1970":219,"1971":220,"1972":221,"1973":222,"1974":223,"1975":224,"1976":225,"1977":226,"1978":227,"1979":228,"1980":229,"1981":230,"1982":231,"1983":232,"1984":233,"1985":234,"1986":235,"1987":236,"1988":237,"1989":238,"1990":239,"1991":240,"1992":241,"1993":242,"1994":243,"1995":244,"1996":245,"1997":246,"1998":247,"1999":248,"2000":249,"2001":250,"2002":251,"2003":252,"2004":253,"2005":254,"2006":255,"2007":256,"2008":257,"2009":258,"2010":259,"2011":260,"2012":261,"2013":262,"2014":263,"2015":264,"2016":265,"2017":266,"2018":267,"2020":268,"2021":269,"2022":109},{"issue":3389,"pages":3391,"volume":3393},{"VOID":3390},"11",{"VOID":3392},"6701-6707",{"VOID":3394},"162",215,{"total":3395,"publishYear":3397,"statisticByYear":3398},1999,{"2000":106,"2001":123,"2002":120,"2003":808,"2004":114,"2005":143,"2006":808,"2007":114,"2008":808,"2009":114,"2010":808,"2011":152,"2012":152,"2013":114,"2014":114,"2015":109,"2016":112,"2017":113,"2018":116,"2019":110,"2020":143,"2021":109,"2022":112,"2023":111,"2024":111,"2025":110},"1999-06-01","2026-07-20T12:58:04.955+00:00",[67,89],[3403,3406,3409,3413,3417,3421,3425,3428,3432,3436,3440,3444,3448,3452,3456,3460,3464,3468,3472,3476,3480,3484,3488,3492,3496,3500,3504,3508,3512,3516,3520,3524,3528,3532,3536,3540,3544,3548,3552],{"id":24,"text":3404,"url":24,"identifiers":3405},"Mocarski, E. S..  1993. Cytomegalovirus biology and replication.  B. Roizman, and R. Whitely, and C. Lopez,  eds. The Human Herpesviruses 173 Raven Press,  New York.",{},{"id":24,"text":3407,"url":24,"identifiers":3408},"Ho, M. 1991. Cytomegalovirus: Biology and Infection. M. Ho, ed. Plenum Publishing, New York.",{},{"id":24,"text":3410,"url":24,"identifiers":3411},"Wiertz, E. J.,  T. R. Jones,  L. Sun,  M. Bogyo,  H. J. Geuze,  H. L. Ploegh.  1996. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell 84: 769",{"doi":3412},"10.1016\u002FS0092-8674(00)81054-5",{"id":24,"text":3414,"url":24,"identifiers":3415},"Kleijnen, M. F.,  H. B. Huppa,  P. Lucin,  S. Mukherjee,  H. Farrell,  A. E. Campbell,  U. H. Koszinowski,  A. B. Hill,  H. L. Pleogh.  1997. A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface. EMBO J. 16: 685",{"doi":3416},"10.1093\u002Femboj\u002F16.4.685",{"id":24,"text":3418,"url":24,"identifiers":3419},"Weitz, E.,  A. Hill,  D. Tortorella,  H. Ploegh.  1997. Cytomegaloviruses use multiple mechanisms to elude the host immune response. Immunol. Lett. 57: 213",{"doi":3420},"10.1016\u002FS0165-2478(97)00073-4",{"id":24,"text":3422,"url":24,"identifiers":3423},"Hengel, H.,  U. H. Koszinowski.  1998. Interference with antigen processing by viruses. Curr. Opin. Immunol. 9: 470",{"doi":3424},"10.1016\u002FS0952-7915(97)80097-0",{"id":24,"text":3426,"url":24,"identifiers":3427},"Sedmak, D. D.,  S. Chaiwiriyakul,  D. A. Knight,  D. J. Birmingham,  E. H. Huang,  W. J. Waldman.  1994. Cytomegalovirus inhibits major histocompatibility class II expression on infected endothelial cells. Am. J. Pathol. 144: 683",{},{"id":24,"text":3429,"url":24,"identifiers":3430},"Ng-Bautista, C. L.,  D. D. Sedmak.  1995. Cytomegalovirus infection is associated with absence of alveolar epithelial cell HLA class II antigen expression. J. Infect. Dis. 171: 39",{"doi":3431},"10.1093\u002Finfdis\u002F171.1.39",{"id":24,"text":3433,"url":24,"identifiers":3434},"Heise, M. T.,  H. W. Virgin.  1995. The T cell independent role of IFN-γ and TNF-α in macrophage activation during murine cytomegalovirus and herpes simplex virus infections. J. Virol. 69: 904",{"doi":3435},"10.1128\u002Fjvi.69.2.904-909.1995",{"id":24,"text":3437,"url":24,"identifiers":3438},"Heise, M. T.,  M. Connick,  H. W. Virgin.  1998. Murine cytomegalovirus inhibits interferon-γ induced antigen presentation to CD4 T cells by macrophages via regulation of expression of MHC class II associated genes. J. Exp. Med. 187: 1037",{"doi":3439},"10.1084\u002Fjem.187.7.1037",{"id":24,"text":3441,"url":24,"identifiers":3442},"Miller, D. M.,  B. M. Rahill,  J. M. Boss,  M. D. Lairmore,  J. E. Durbin,  W. J. Waldman,  D. D. Sedmak.  1998. Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak\u002FStat pathway. J. Exp. Med. 187: 675",{"doi":3443},"10.1084\u002Fjem.187.5.675",{"id":24,"text":3445,"url":24,"identifiers":3446},"Kuhn, R.,  J. Lohler,  D. Rennick,  K. Rajewsky,  W. Muller.  1993. Interleukin-10 deficient mice develop chronic enterocolitis. Cell 75: 263",{"doi":3447},"10.1016\u002F0092-8674(93)80068-P",{"id":24,"text":3449,"url":24,"identifiers":3450},"Mauel, J.,  D. Defendi.  1971. Infection and transformation of mouse peritoneal macrophages by simian virus 40. J. Exp. Med. 134: 335",{"doi":3451},"10.1084\u002Fjem.134.2.335",{"id":24,"text":3453,"url":24,"identifiers":3454},"Lowy, D. R.,  E. Rands,  E. M. Scolnick.  1978. Helper independent transformation by unintegrated Harvey Sarcoma Virus DNA. J. Virol. 26: 291",{"doi":3455},"10.1128\u002Fjvi.26.2.291-298.1978",{"id":24,"text":3457,"url":24,"identifiers":3458},"Ferrick, D. A.,  M. D. Schrenzel,  T. Mulvania,  B. Hsieh,  W. G. Ferlin,  H. Lepper.  1995. Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ cells in vivo. Nature 373: 255",{"doi":3459},"10.1038\u002F373255a0",{"id":24,"text":3461,"url":24,"identifiers":3462},"Stoddard, C. A.,  R. D. Cardin,  J. M. Boname,  W. C. Manning,  G. B. Abenes,  E. S. Mocarski.  1994. Peripheral blood mononuclear phagocytes mediate dissemination of murine cytomegalovirus. J. Virol. 68: 6235",{"doi":3463},"10.1128\u002Fjvi.68.10.6243-6253.1994",{"id":24,"text":3465,"url":24,"identifiers":3466},"Pollock, H. L.,  R. M. Presti,  S. Paetzold,  H. W. Virgin.  1997. Latent murine cytomegalovirus infection in macrophages. Virology 227: 168",{"doi":3467},"10.1006\u002Fviro.1996.8303",{"id":24,"text":3469,"url":24,"identifiers":3470},"Cavanaugh, V. J.,  R. M. Stenberg,  T. L. Staley,  H. W. Virgin,  M. R. MacDonald,  S. Paetzold,  H. E. Farrell,  W. D. Rawlinson,  A. E. Campbell.  1996. Murine cytomegalovirus with a deletion of genes spanning HindIII-J and -I displays altered cell and tissue trophism. J. Virol. 70: 1365",{"doi":3471},"10.1128\u002Fjvi.70.3.1365-1374.1996",{"id":24,"text":3473,"url":24,"identifiers":3474},"Moore, K. W.,  A. O’Garra,  R. de Waal Malefyt,  P. Vieira,  T. Mosmann.  1993. Interleukin-10. Annu. Rev. Immunol. 11: 165",{"doi":3475},"10.1146\u002Fannurev.iy.11.040193.001121",{"id":24,"text":3477,"url":24,"identifiers":3478},"Koppleman, B.,  J. J. Neefjes,  J. E. de Vries,  R. de Waal Malefyt.  1997. Interleukin-10 down-regulates MHC class II αβ peptide complexes at the plasma membrane of monocytes by affecting arrival and recycling. Immunity 7: 861",{"doi":3479},"10.1016\u002FS1074-7613(00)80404-5",{"id":24,"text":3481,"url":24,"identifiers":3482},"Di Marizio, P.,  P. Puddu,  L. Conti,  F. Berlardelli,  S. Gessani.  1994. Interferon γ up-regulates its own gene expression in mouse peritoneal macrophages. J. Exp. Med. 179: 1731",{"doi":3483},"10.1084\u002Fjem.179.5.1731",{"id":24,"text":3485,"url":24,"identifiers":3486},"Katzenstein, D. A.,  G. S. Yu,  M. C. Jordan.  1983. Lethal infection with murine cytomegalovirus after early viral replication in the spleen. J. Infect. Dis. 148: 406",{"doi":3487},"10.1093\u002Finfdis\u002F148.3.406",{"id":24,"text":3489,"url":24,"identifiers":3490},"Soderberg-Naucler, C.,  K. N. Fish,  J. A. Nelson.  1997. Reactivation of latent human cytomegalovirus by allogeneic stimulation of blood cells from healthy donors. Cell 91: 119",{"doi":3491},"10.1016\u002FS0092-8674(01)80014-3",{"id":24,"text":3493,"url":24,"identifiers":3494},"Taylor-Wiedeman, J.,  J. P. G. Sissons,  L. K. Borysiewicz,  J. H. Sinclair.  1991. Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells. J. Gen. Virol. 72: 2059",{"doi":3495},"10.1099\u002F0022-1317-72-9-2059",{"id":24,"text":3497,"url":24,"identifiers":3498},"Taylor-Wiedeman, J.,  J. P. G. Sissons,  J. Sinclair.  1994. Induction of endogenous human cytomegalovirus gene expression after differentiation of monocytes from healthy carriers. J. Virol. 68: 1597",{"doi":3499},"10.1128\u002Fjvi.68.3.1597-1604.1994",{"id":24,"text":3501,"url":24,"identifiers":3502},"Kondo, K.,  H. Kaneshima,  E. S. Mocarski.  1994. Human cytomegalovirus latent infection of granulocyte-macrophage progenitors. Proc. Natl. Acad. Sci. USA 91: 11897",{"doi":3503},"10.1073\u002Fpnas.91.25.11879",{"id":24,"text":3505,"url":24,"identifiers":3506},"Minton, E. J.,  C. Tysoe,  J. H. Sinclair,  J. P. G. Sissons.  1994. Human cytomegalovirus infection of the monocyte\u002Fmacrophage lineage in bone marrow. J. Virol. 68: 4017",{"doi":3507},"10.1128\u002Fjvi.68.6.4017-4021.1994",{"id":24,"text":3509,"url":24,"identifiers":3510},"Heise, M. T.,  J. L. Pollock,  A. O’Guin,  M. L. Barkon,  S. Bromley,  H. W. Virgin.  1998. Murine cytomegalovirus infection inhibits IFN-γ induced MHC class II expression on macrophages: the role of type I interferon. Virology 241: 331",{"doi":3511},"10.1006\u002Fviro.1997.8969",{"id":24,"text":3513,"url":24,"identifiers":3514},"Matsuda, M.,  F. Salazar,  M. Petersson,  G. Masucci,  J. Hansson,  P. Pisa,  Q.-J. Zhang,  M. G. Masucci,  R. Kiessling.  1994. Interleukin 10 pretreatment protects target cells from tumor and allo-specific cytotoxic T cells and down-regulates HLA class I expression. J. Exp. Med. 180: 2371",{"doi":3515},"10.1084\u002Fjem.180.6.2371",{"id":24,"text":3517,"url":24,"identifiers":3518},"Petersson, M.,  J. Charo,  F. Salazar-Onfray,  G. Noffz,  M. Mohaupt,  Z. Qin,  G. Klien,  T. Blankenstein,  R. Kiessling.  1998. Constitutive IL-10 production accounts for the high NK sensitivity, low MHC class I expression, and poor transporter associated with antigen processing (TAP)-1\u002F2 function in the prototype NK target YAC-1. J. Immunol. 161: 2099",{"doi":3519},"10.4049\u002Fjimmunol.161.5.2099",{"id":24,"text":3521,"url":24,"identifiers":3522},"Orange, J. S.,  B. Wang,  C. Terhorst,  C. A. Biron.  1995. Requirement for natural killer cell-produced IFN-γ in defense against murine cytomegalovirus infection and enhancement of this defense pathway by IL-12 administration. J. Exp. Med. 182: 1045",{"doi":3523},"10.1084\u002Fjem.182.4.1045",{"id":24,"text":3525,"url":24,"identifiers":3526},"Orange, J. S.,  C. A. Biron.  1996. An absolute and restricted requirement for IL-12 in natural killer cell IFN-γ production and antiviral defense: studies of natural killer and T cell responses in contrasting viral infections. J. Immunol. 156: 1138",{"doi":3527},"10.4049\u002Fjimmunol.156.3.1138",{"id":24,"text":3529,"url":24,"identifiers":3530},"Orange, J. S.,  C. A. Biron.  1996. Characterization of early IL-12, IFN-γ and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. J. Immunol. 156: 4746",{"doi":3531},"10.4049\u002Fjimmunol.156.12.4746",{"id":24,"text":3533,"url":24,"identifiers":3534},"Cousens, L. P.,  J. S. Orange,  C. A. Biron.  1997. Interferon-α\u002Fβ inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection. Proc. Natl. Acad. Sci. USA 94: 634",{"doi":3535},"10.1073\u002Fpnas.94.2.634",{"id":24,"text":3537,"url":24,"identifiers":3538},"Orange, J. S.,  T. P. Salazar-Mather,  S. M. Opal,  C. A. Biron.  1997. Mechanisms for virus induced liver disease: tumor necrosis factor-mediated pathology independent of natural killer and T cells during murine cytomegalovirus infection. J. Virol. 71: 9248",{"doi":3539},"10.1128\u002Fjvi.71.12.9248-9258.1997",{"id":24,"text":3541,"url":24,"identifiers":3542},"Yerkovich, S. T.,  S. D. Olver,  J. C. Lenzo,  C. D. Peacock,  P. Price.  1997. The roles of tumor necrosis factor-α, interleukin-1 and interleukin-12 in murine cytomegalovirus infection. Immunology 91: 45",{"doi":3543},"10.1046\u002Fj.1365-2567.1997.00226.x",{"id":24,"text":3545,"url":24,"identifiers":3546},"De Waal-Malefyt, R.,  J. Haanen,  H. Spits,  M. G. Roncarolo,  A. te Velde,  C. Figdor,  K. Johnson,  R. Kastelenein,  H. Yssel,  J. E. de Vries.  1991. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via down-regulation of class II MHC expression. J. Exp. Med. 174: 915",{"doi":3547},"10.1084\u002Fjem.174.4.915",{"id":24,"text":3549,"url":24,"identifiers":3550},"Flesch, I. E. A.,  S. H. E. Kaufmann.  1994. Role of macrophages and αβ T lymphocytes in early interleukin 10 production during Listeria monocytogenes infection. Int. Immunol. 6: 463",{"doi":3551},"10.1093\u002Fintimm\u002F6.3.463",{"id":24,"text":3553,"url":24,"identifiers":3554},"Panuska, J. R.,  R. Merolla,  N. A. Rebert,  S. P. Hoffmann,  P. Tsivitse,  N. M. Cirino,  H. R. Silverman,  J. A. Rankin.  1995. Respiratory syncytial virus induces interleukin-10 by human alveolar macrophages. J. Clin. Invest. 96: 2445",{"doi":3555},"10.1172\u002FJCI118302"]