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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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Immunol., 161, 2708, 10.4049\u002Fjimmunol.161.6.2708",{"doi":1594},"10.4049\u002Fjimmunol.161.6.2708",{"id":28,"text":1596,"url":28,"identifiers":1597},"Ling, 2000, Identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor, J. Immunol., 164, 1653, 10.4049\u002Fjimmunol.164.4.1653",{"doi":1598},"10.4049\u002Fjimmunol.164.4.1653",{"id":28,"text":1600,"url":28,"identifiers":1601},"Blair, 1998, CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-XL induction, J. Immunol., 160, 12, 10.4049\u002Fjimmunol.160.1.12",{"doi":1602},"10.4049\u002Fjimmunol.160.1.12",{"id":28,"text":1604,"url":28,"identifiers":1605},"Byrne, 2000, Preparation of mRNA for expression monitoring, Current Protocols in Molecular Biology Supplement. Vol. 49, 22",{},{"id":28,"text":1607,"url":28,"identifiers":1608},"Freeman, 1992, CTLA-4 and CD28 are coexpressed in most T-cells after activation, J. Immunol., 149, 3795, 10.4049\u002Fjimmunol.149.12.3795",{"doi":1609},"10.4049\u002Fjimmunol.149.12.3795",{"id":28,"text":1611,"url":28,"identifiers":1612},"Boussiotis, 1996, The role of B7-1\u002FB7-2:CD28\u002FCTLA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response, Immunol. Rev., 153, 5, 10.1111\u002Fj.1600-065X.1996.tb00918.x",{"doi":1613},"10.1111\u002Fj.1600-065X.1996.tb00918.x",{"id":28,"text":1615,"url":28,"identifiers":1616},"Dong, 1999, B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion, Nat. 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These converted anergic\u002Fsuppressor cells are not only unresponsive to TCR stimulation and produce neither T helper cell 1 nor T helper cell 2 cytokines but they also express TGF-β and inhibit normal T cell proliferation in vitro. More importantly, in an ovalbumin peptide TCR transgenic adoptive transfer model, TGF-β–converted transgenic CD4+CD25+ suppressor cells proliferated in response to immunization and inhibited antigen-specific naive CD4+ T cell expansion in vivo. Finally, in a murine asthma model, coadministration of these TGF-β–induced suppressor T cells prevented house dust mite–induced allergic pathogenesis in lungs.\u003C\u002Fjats:p>","\u003Cjats:p>Các tế bào T điều hòa CD4+CD25+ (Treg) đóng vai trò quan trọng trong việc duy trì sự dung nạp miễn dịch. Một câu hỏi quan trọng là liệu Treg có thể chỉ được tạo ra trong tuyến ức hay có thể phân biệt từ các tế bào T CD4+CD25− naiv ở ngoại biên. Trong bài báo này, chúng tôi trình bày những chứng cứ mới cho thấy việc chuyển đổi các tế bào T CD4+CD25− naiv ở ngoại biên thành các tế bào bất hoạt\u002Fức chế có dấu hiệu CD25+, CD45RB−\u002Fthấp và CTLA-4 nội bào+ có thể đạt được thông qua kích thích đồng thời với thụ thể tế bào T (TCR) và yếu tố tăng trưởng chuyển đổi β (TGF-β). Mặc dù gần đây yếu tố phiên mã Foxp3 đã được chứng minh là liên quan đến sự phát triển của Treg, các tác nhân sinh lý để biểu hiện gen Foxp3 vẫn còn là một bí ẩn. TGF-β kích thích biểu hiện gen Foxp3 trong các tế bào T CD4+CD25− naiv bị thách thức bởi TCR, điều này khiến chúng chuyển sang kiểu hình tế bào T điều hòa với khả năng ức chế miễn dịch mạnh mẽ. Những tế bào bất hoạt\u002Fức chế đã chuyển đổi này không chỉ không phản ứng với sự kích thích TCR và không sản xuất cytokine tế bào T hỗ trợ 1 hoặc 2, mà chúng còn biểu hiện TGF-β và ức chế sự phát triển bình thường của tế bào T trong ống nghiệm. Quan trọng hơn, trong một mô hình chuyển giao tế bào TCR transgenic peptide ovalbumin, các tế bào ức chế CD4+CD25+ transgenic được chuyển đổi bởi TGF-β đã tăng sinh đáp ứng với việc tiêm chủng và ức chế sự mở rộng của tế bào T CD4+ naiv đặc hiệu kháng nguyên trong cơ thể sống. Cuối cùng, trong một mô hình hen suyễn ở chuột, việc đồng quản trị các tế bào T ức chế do TGF-β gây ra đã ngăn ngừa sự sinh bệnh dị ứng do bụi nhà gây ra trong phổi.\u003C\u002Fjats:p>",{"EN":1684,"VI":1685},"Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor \u003Ci>Foxp3 \u003C\u002Fi>","Chuyển đổi tế bào T CD4+CD25− T naiv thành tế bào T điều hòa CD4+CD25+ thông qua sự kích thích của TGF-β đối với yếu tố phiên mã \u003Ci>Foxp3\u003C\u002Fi>",{"VOID":1687},"14676299",{"VOID":1689},"10.1084\u002Fjem.20030152",[31],[30],"https:\u002F\u002Frupress.org\u002Fjem\u002Farticle\u002F198\u002F12\u002F1875\u002F39939\u002FConversion-of-Peripheral-CD4-CD25-Naive-T-Cells-to",[1694,1711,1730,1745,1760,1777,1792,1807],{"id":1695,"sortIndex":32,"researcher":28,"roles":1696,"affiliations":1697,"properties":1706,"displayName":1708,"givenName":28,"familyName":28},"10ef71d7-e139-49e5-8135-868fe458b072",[],[1698],{"id":1699,"sortIndex":32,"affiliation":1700,"properties":28},"dfd0b9a9-576e-4214-9fea-fbf97bcb692c",{"id":1699,"createTime":28,"updateTime":28,"relativeEntities":1701,"slug":28,"properties":1702,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1705,"statistic":28},[],{"title":1703},{"VI":1704},"Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 USA",[],{"title":1707,"openalex":1709},{"EN":1708},"WanJun Chen",{"VOID":1710},"A5025752056",{"id":1712,"sortIndex":40,"researcher":28,"roles":1713,"affiliations":1714,"properties":1723,"displayName":1727,"givenName":28,"familyName":28},"b014c93e-7308-499e-8dc3-357e00796f7e",[],[1715],{"id":1716,"sortIndex":32,"affiliation":1717,"properties":28},"a4167855-9992-4d7d-934e-3bd66170445c",{"id":1716,"createTime":28,"updateTime":28,"relativeEntities":1718,"slug":28,"properties":1719,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1722,"statistic":28},[],{"title":1720},{"EN":1721},"Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892",[],{"orcid":1724,"title":1726,"openalex":1728},{"VOID":1725},"https:\u002F\u002Forcid.org\u002F0000-0001-7771-3058",{"EN":1727},"Wenwen Jin",{"VOID":1729},"A5102984665",{"id":1731,"sortIndex":123,"researcher":28,"roles":1732,"affiliations":1733,"properties":1740,"displayName":1742,"givenName":28,"familyName":28},"a832ff77-3e6b-4bfb-a0eb-8aee095e8293",[],[1734],{"id":1716,"sortIndex":32,"affiliation":1735,"properties":28},{"id":1716,"createTime":28,"updateTime":28,"relativeEntities":1736,"slug":28,"properties":1737,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1739,"statistic":28},[],{"title":1738},{"EN":1721},[],{"title":1741,"openalex":1743},{"EN":1742},"Neil J. 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Rev. Immunol., 2, 389, 10.1038\u002Fnri821",{"doi":1902},"10.1038\u002Fnri821",{"id":28,"text":1904,"url":28,"identifiers":1905},"1999, J. Immunol., 162, 5317, 10.4049\u002Fjimmunol.162.9.5317",{"doi":1906},"10.4049\u002Fjimmunol.162.9.5317",{"id":28,"text":1908,"url":28,"identifiers":1909},"2002, Nat. Immunol., 3, 756, 10.1038\u002Fni816",{"doi":1910},"10.1038\u002Fni816",{"id":28,"text":1912,"url":28,"identifiers":1913},"2001, J. Immunol., 167, 4245, 10.4049\u002Fjimmunol.167.8.4245",{"doi":1914},"10.4049\u002Fjimmunol.167.8.4245",{"id":28,"text":1916,"url":28,"identifiers":1917},"2002, Nat. Rev. Immunol., 2, 46, 10.1038\u002Fnri704",{"doi":1918},"10.1038\u002Fnri704",{"id":28,"text":1920,"url":28,"identifiers":1921},"2002, Curr. Dir. Autoimmun., 5, 62",{},{"id":28,"text":1923,"url":28,"identifiers":1924},"2000, Immunity., 12, 171, 10.1016\u002FS1074-7613(00)80170-3",{"doi":1925},"10.1016\u002FS1074-7613(00)80170-3",{"id":28,"text":1927,"url":28,"identifiers":1928},"2000, J. Exp. Med., 191, 1187, 10.1084\u002Fjem.191.7.1187",{"doi":1929},"10.1084\u002Fjem.191.7.1187",{"id":28,"text":1931,"url":28,"identifiers":1932},"2001, J. Immunol., 166, 7282, 10.4049\u002Fjimmunol.166.12.7282",{"doi":1933},"10.4049\u002Fjimmunol.166.12.7282",{"id":28,"text":1935,"url":28,"identifiers":1936},"2001, Nat. Genet., 27, 68",{},{"id":28,"text":1938,"url":28,"identifiers":1939},"2001, Nat. Genet., 27, 18, 10.1038\u002F83707",{"doi":1940},"10.1038\u002F83707",{"id":28,"text":1942,"url":28,"identifiers":1943},"2003, Science., 299, 1057, 10.1126\u002Fscience.1079490",{"doi":1944},"10.1126\u002Fscience.1079490",{"id":28,"text":1946,"url":28,"identifiers":1947},"2003, Nat. Immunol., 4, 337",{},{"id":28,"text":1949,"url":28,"identifiers":1950},"2003, Nat. Immunol., 4, 330, 10.1038\u002Fni904",{"doi":1951},"10.1038\u002Fni904",{"id":28,"text":1953,"url":28,"identifiers":1954},"1995, Immunity., 3, 541, 10.1016\u002F1074-7613(95)90125-6",{"doi":1641},{"id":28,"text":1956,"url":28,"identifiers":1957},"1995, Science., 270, 985, 10.1126\u002Fscience.270.5238.985",{"doi":1645},{"id":28,"text":1959,"url":28,"identifiers":1960},"1993, Proc. Natl. Acad. Sci. USA., 90, 770, 10.1073\u002Fpnas.90.2.770",{"doi":1961},"10.1073\u002Fpnas.90.2.770",{"id":28,"text":1963,"url":28,"identifiers":1964},"1992, Nature., 359, 693, 10.1038\u002F359693a0",{"doi":1965},"10.1038\u002F359693a0",{"id":28,"text":1967,"url":28,"identifiers":1968},"1998, J. Exp. Med., 188, 1849, 10.1084\u002Fjem.188.10.1849",{"doi":1969},"10.1084\u002Fjem.188.10.1849",{"id":28,"text":1971,"url":28,"identifiers":1972},"2001, J. Exp. Med., 194, 439, 10.1084\u002Fjem.194.4.439",{"doi":1973},"10.1084\u002Fjem.194.4.439",{"id":28,"text":1975,"url":28,"identifiers":1976},"1998, J. Exp. Med., 188, 287, 10.1084\u002Fjem.188.2.287",{"doi":1977},"10.1084\u002Fjem.188.2.287",{"id":28,"text":1979,"url":28,"identifiers":1980},"2000, Immunity., 12, 431, 10.1016\u002FS1074-7613(00)80195-8",{"doi":1981},"10.1016\u002FS1074-7613(00)80195-8",{"id":28,"text":1983,"url":28,"identifiers":1984},"2001, Immunity., 14, 715, 10.1016\u002FS1074-7613(01)00147-9",{"doi":1985},"10.1016\u002FS1074-7613(01)00147-9",{"id":28,"text":1987,"url":28,"identifiers":1988},"1998, Science., 282, 2258, 10.1126\u002Fscience.282.5397.2258",{"doi":1989},"10.1126\u002Fscience.282.5397.2258",{"id":28,"text":1991,"url":28,"identifiers":1992},"1996, J. Exp. Med., 184, 1, 10.1084\u002Fjem.184.1.1",{"doi":1993},"10.1084\u002Fjem.184.1.1",{"id":28,"text":1995,"url":28,"identifiers":1996},"2000, J. Exp. Med., 192, 295, 10.1084\u002Fjem.192.2.295",{"doi":1997},"10.1084\u002Fjem.192.2.295",{"id":28,"text":1999,"url":28,"identifiers":2000},"2000, J. Exp. Med., 192, 303, 10.1084\u002Fjem.192.2.303",{"doi":2001},"10.1084\u002Fjem.192.2.303",{"id":28,"text":2003,"url":28,"identifiers":2004},"2001, J. Exp. Med., 194, 629, 10.1084\u002Fjem.194.5.629",{"doi":2005},"10.1084\u002Fjem.194.5.629",{"id":28,"text":2007,"url":28,"identifiers":2008},"2003, Cytokine Growth Factor Rev., 14, 85, 10.1016\u002FS1359-6101(03)00003-0",{"doi":2009},"10.1016\u002FS1359-6101(03)00003-0",{"id":28,"text":2011,"url":28,"identifiers":2012},"2003, J. Exp. Med., 198, 249, 10.1084\u002Fjem.20030315",{"doi":2013},"10.1084\u002Fjem.20030315",{"id":28,"text":2015,"url":28,"identifiers":2016},"2003, Proc. Natl. Acad. Sci. USA., 100, 8886, 10.1073\u002Fpnas.1533365100",{"doi":2017},"10.1073\u002Fpnas.1533365100",{"id":28,"text":2019,"url":28,"identifiers":2020},"2003, Nat. Rev. Immunol., 3, 253, 10.1038\u002Fnri1032",{"doi":2021},"10.1038\u002Fnri1032",{"id":28,"text":2023,"url":28,"identifiers":2024},"2001, Nat. Immunol., 2, 816, 10.1038\u002Fni0901-816",{"doi":2025},"10.1038\u002Fni0901-816",{"id":28,"text":2027,"url":28,"identifiers":2028},"2001, Immunol. Rev., 182, 149, 10.1034\u002Fj.1600-065X.2001.1820112.x",{"doi":2029},"10.1034\u002Fj.1600-065X.2001.1820112.x",{"id":28,"text":2031,"url":28,"identifiers":2032},"2002, J. Exp. Med., 196, 255, 10.1084\u002Fjem.20020394",{"doi":2033},"10.1084\u002Fjem.20020394",{"id":28,"text":2035,"url":28,"identifiers":2036},"2002, J. Immunol., 168, 4272, 10.4049\u002Fjimmunol.168.9.4272",{"doi":2037},"10.4049\u002Fjimmunol.168.9.4272",{"id":28,"text":2039,"url":28,"identifiers":2040},"2003, Immunity., 19, 165, 10.1016\u002FS1074-7613(03)00207-3",{"doi":2041},"10.1016\u002FS1074-7613(03)00207-3",{"id":28,"text":2043,"url":28,"identifiers":2044},"1997, Nature., 389, 737, 10.1038\u002F39614",{"doi":2045},"10.1038\u002F39614",{"id":28,"text":2047,"url":28,"identifiers":2048},"2003, Nat. Rev. Immunol., 3, 405, 10.1038\u002Fnri1084",{"doi":2049},"10.1038\u002Fnri1084",{"id":2051,"createTime":2052,"updateTime":2053,"relativeEntities":2054,"slug":2055,"properties":2056,"entityType":1159,"verifyStatus":26,"verifyTime":2052,"verifyNote":1161,"languages":2074,"translateLanguages":2075,"viewCount":32,"primaryUrl":2076,"fullTextUrl":28,"authors":2077,"publicationType":1477,"publisherRelationship":2227,"citationCount":2286,"citationInfo":2287,"publishDate":2294,"publishYear":2288,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":2295,"openAccess":28,"references":2296,"isForceReanalyzing":1665},"24a302ab-700c-4ed1-bbfc-bbaf7a7408f6","2024-09-27T07:39:46.802+00:00","2025-02-24T11:44:57.716+00:00",[],"IL-23-drives-a-pathogenic-T-cell-population-that-induces-autoimmune-inflammation",{"mag":2057,"keywords":2059,"pmc":2060,"openalex":2062,"abstract":2064,"title":2067,"pm":2070,"doi":2072},{"VOID":2058},"2006249161",{"VI":1144},{"VOID":2061},"2212798",{"VOID":2063},"W2006249161",{"EN":2065,"VI":2066},"\u003Cjats:p>Interleukin (IL)-23 is a heterodimeric cytokine composed of a unique p19 subunit, and a common p40 subunit shared with IL-12. IL-12 is important for the development of T helper (Th)1 cells that are essential for host defense and tumor suppression. In contrast, IL-23 does not promote the development of interferon-γ–producing Th1 cells, but is one of the essential factors required for the expansion of a pathogenic CD4+ T cell population, which is characterized by the production of IL-17, IL-17F, IL-6, and tumor necrosis factor. Gene expression analysis of IL-23–driven autoreactive T cells identified a unique expression pattern of proinflammatory cytokines and other novel factors, distinguishing them from IL-12–driven T cells. Using passive transfer studies, we confirm that these IL-23–dependent CD4+ T cells are highly pathogenic and essential for the establishment of organ-specific inflammation associated with central nervous system autoimmunity.\u003C\u002Fjats:p>","\u003Cjats:p>Interleukin (IL)-23 là một cytokine heterodimeric bao gồm một chuỗi p19 độc nhất và một chuỗi p40 chung được chia sẻ với IL-12. IL-12 quan trọng cho sự phát triển của tế bào T hỗ trợ (Th)1, những tế bào thiết yếu cho sự bảo vệ của cơ thể và ức chế khối u. Ngược lại, IL-23 không thúc đẩy sự phát triển của các tế bào Th1 sản xuất interferon-γ, mà là một trong những yếu tố thiết yếu cần thiết cho việc mở rộng quần thể tế bào T CD4+ gây bệnh, được đặc trưng bởi sự sản xuất của IL-17, IL-17F, IL-6 và yếu tố hoại tử u. Phân tích biểu hiện gen của các tế bào T tự phản ứng driven bởi IL-23 xác định một mô hình biểu hiện độc nhất của các cytokine proinflammatory và các yếu tố mới khác, phân biệt chúng với các tế bào T driven bởi IL-12. Sử dụng các nghiên cứu chuyển giao thụ động, chúng tôi xác nhận rằng các tế bào T CD4+ phụ thuộc vào IL-23 này có tính gây bệnh cao và thiết yếu cho việc thiết lập viêm cụ thể theo cơ quan liên quan đến tự miễn dịch hệ thần kinh trung ương.\u003C\u002Fjats:p>",{"EN":2068,"VI":2069},"IL-23 drives a pathogenic T cell population that induces autoimmune inflammation","IL-23 thúc đẩy quần thể tế bào T gây bệnh gây ra viêm tự miễn",{"VOID":2071},"15657292",{"VOID":2073},"10.1084\u002Fjem.20041257",[31],[30],"https:\u002F\u002Frupress.org\u002Fjem\u002Farticle\u002F201\u002F2\u002F233\u002F54835\u002FIL-23-drives-a-pathogenic-T-cell-population-that",[2078,2097,2116,2133,2148,2165,2180,2195,2210],{"id":2079,"sortIndex":32,"researcher":28,"roles":2080,"affiliations":2081,"properties":2090,"displayName":2094,"givenName":28,"familyName":28},"4831517f-45bf-463b-b438-072926ff0227",[],[2082],{"id":2083,"sortIndex":32,"affiliation":2084,"properties":28},"13ee7dd5-8a31-442c-b708-1838f949f1cd",{"id":2083,"createTime":28,"updateTime":28,"relativeEntities":2085,"slug":28,"properties":2086,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2089,"statistic":28},[],{"title":2087},{"EN":2088},"Discovery Research, DNAX Research Inc., Palo Alto, CA 94304, USA.",[],{"orcid":2091,"title":2093,"openalex":2095},{"VOID":2092},"https:\u002F\u002Forcid.org\u002F0000-0001-8222-8153",{"EN":2094},"Claire L. 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Nature., 421, 744, 10.1038\u002Fnature01355",{"doi":2300},"10.1038\u002Fnature01355",{"id":28,"text":2302,"url":28,"identifiers":2303},"2003, J. Exp. Med., 198, 1951, 10.1084\u002Fjem.20030896",{"doi":2304},"10.1084\u002Fjem.20030896",{"id":28,"text":2306,"url":28,"identifiers":2307},"2000, Immunity., 13, 715, 10.1016\u002FS1074-7613(00)00070-4",{"doi":2308},"10.1016\u002FS1074-7613(00)00070-4",{"id":28,"text":2310,"url":28,"identifiers":2311},"2000, Trends Cell Biol., 10, 542, 10.1016\u002FS0962-8924(00)01856-0",{"doi":2312},"10.1016\u002FS0962-8924(00)01856-0",{"id":28,"text":2314,"url":28,"identifiers":2315},"2001, Curr. Opin. Microbiol., 4, 251, 10.1016\u002FS1369-5274(00)00199-5",{"doi":2316},"10.1016\u002FS1369-5274(00)00199-5",{"id":28,"text":2318,"url":28,"identifiers":2319},"2004, J. Clin. Invest., 113, 1651, 10.1172\u002FJCI200420303",{"doi":2320},"10.1172\u002FJCI200420303",{"id":28,"text":2322,"url":28,"identifiers":2323},"2004, J. Immunol., 173, 1887, 10.4049\u002Fjimmunol.173.3.1887",{"doi":2324},"10.4049\u002Fjimmunol.173.3.1887",{"id":28,"text":2326,"url":28,"identifiers":2327},"1996, J. Immunol., 156, 5, 10.4049\u002Fjimmunol.156.1.5",{"doi":2328},"10.4049\u002Fjimmunol.156.1.5",{"id":28,"text":2330,"url":28,"identifiers":2331},"1996, J. Immunol., 157, 3223, 10.4049\u002Fjimmunol.157.8.3223",{"doi":2332},"10.4049\u002Fjimmunol.157.8.3223",{"id":28,"text":2334,"url":28,"identifiers":2335},"2003, J. Immunol., 170, 2153, 10.4049\u002Fjimmunol.170.4.2153",{"doi":2336},"10.4049\u002Fjimmunol.170.4.2153",{"id":28,"text":2338,"url":28,"identifiers":2339},"2002, J. Clin. Invest., 110, 493, 10.1172\u002FJCI0215751",{"doi":2340},"10.1172\u002FJCI0215751",{"id":28,"text":2342,"url":28,"identifiers":2343},"2002, J. Immunol., 169, 7104, 10.4049\u002Fjimmunol.169.12.7104",{"doi":2344},"10.4049\u002Fjimmunol.169.12.7104",{"id":28,"text":2346,"url":28,"identifiers":2347},"1991, Brain Pathol., 1, 97, 10.1111\u002Fj.1750-3639.1991.tb00646.x",{"doi":2348},"10.1111\u002Fj.1750-3639.1991.tb00646.x",{"id":28,"text":2350,"url":28,"identifiers":2351},"2004, J. Immunol., 172, 2827, 10.4049\u002Fjimmunol.172.5.2827",{"doi":2352},"10.4049\u002Fjimmunol.172.5.2827",{"id":28,"text":2354,"url":28,"identifiers":2355},"2003, J. Biol. Chem., 278, 1910, 10.1074\u002Fjbc.M207577200",{"doi":2356},"10.1074\u002Fjbc.M207577200",{"id":28,"text":2358,"url":28,"identifiers":2359},"1999, J. Immunol., 162, 1246, 10.4049\u002Fjimmunol.162.3.1246",{"doi":2360},"10.4049\u002Fjimmunol.162.3.1246",{"id":28,"text":2362,"url":28,"identifiers":2363},"2003, J. Immunol., 170, 4432, 10.4049\u002Fjimmunol.170.9.4432",{"doi":2364},"10.4049\u002Fjimmunol.170.9.4432",{"id":28,"text":2366,"url":28,"identifiers":2367},"1988, J. Cell. Biochem., 37, 385, 10.1002\u002Fjcb.240370406",{"doi":2368},"10.1002\u002Fjcb.240370406",{"id":28,"text":2370,"url":28,"identifiers":2371},"2001, J. Immunol., 167, 6957, 10.4049\u002Fjimmunol.167.12.6957",{"doi":2372},"10.4049\u002Fjimmunol.167.12.6957",{"id":28,"text":2374,"url":28,"identifiers":2375},"2003, J. Immunol., 171, 6173, 10.4049\u002Fjimmunol.171.11.6173",{"doi":2376},"10.4049\u002Fjimmunol.171.11.6173",{"id":28,"text":2378,"url":28,"identifiers":2379},"2003, Proc. Natl. Acad. Sci. USA., 100, 5986, 10.1073\u002Fpnas.1035999100",{"doi":2380},"10.1073\u002Fpnas.1035999100",{"id":28,"text":2382,"url":28,"identifiers":2383},"1987, Lancet., 1, 893",{},{"id":28,"text":2385,"url":28,"identifiers":2386},"1998, Mol. Cell. Neurosci., 12, 376, 10.1006\u002Fmcne.1998.0725",{"doi":2387},"10.1006\u002Fmcne.1998.0725",{"id":28,"text":2389,"url":28,"identifiers":2390},"1995, Mol. Med., 1, 732, 10.1007\u002FBF03401888",{"doi":2391},"10.1007\u002FBF03401888",{"id":28,"text":2393,"url":28,"identifiers":2394},"1995, J. Exp. Med., 181, 381, 10.1084\u002Fjem.181.1.381",{"doi":2395},"10.1084\u002Fjem.181.1.381",{"id":28,"text":2397,"url":28,"identifiers":2398},"1996, J. Exp. Med., 184, 771, 10.1084\u002Fjem.184.2.771",{"doi":2399},"10.1084\u002Fjem.184.2.771",{"id":28,"text":2401,"url":28,"identifiers":2402},"2002, Nat. Immunol., 3, 852, 10.1038\u002Fni832",{"doi":2403},"10.1038\u002Fni832",{"id":28,"text":2405,"url":28,"identifiers":2406},"2003, J. Clin. Invest., 111, 701, 10.1172\u002FJCI17321",{"doi":2407},"10.1172\u002FJCI17321",{"id":28,"text":2409,"url":28,"identifiers":2410},"2004, Arthritis Rheum., 50, 650, 10.1002\u002Fart.20001",{"doi":2411},"10.1002\u002Fart.20001",{"id":28,"text":2413,"url":28,"identifiers":2414},"1999, Mult. Scler., 5, 101, 10.1177\u002F135245859900500206",{"doi":2415},"10.1177\u002F135245859900500206",{"id":28,"text":2417,"url":28,"identifiers":2418},"2000, J. Immunol., 164, 2832, 10.4049\u002Fjimmunol.164.5.2832",{"doi":2419},"10.4049\u002Fjimmunol.164.5.2832",{"id":28,"text":2421,"url":28,"identifiers":2422},"1998, J. Invest. 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Mỗi đốm do đó xuất phát từ một hạt virus đơn lẻ, được định nghĩa là đơn vị virus không thể tách rời bằng cách pha loãng. Các đốm này xuất hiện do tác động đặc hiệu của virus vì chúng bị ức chế bởi huyết thanh đặc hiệu từng loại.\u003C\u002Fjats:p>\n               \u003Cjats:p>Các dòng virus tinh khiết đã được thiết lập bằng cách tách biệt quần thể virus được sản xuất từ các đốm đơn lẻ. 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cầu đơn nhân, interleukin 10, lipopolysaccharides, tổng hợp cytokine, yếu tố hòa hợp mô chính II, IL-1 alpha, IL-1 beta, IL-6, IL-8, TNF alpha, GM-CSF, G-CSF, điều hòa tự động, đáp ứng miễn dịch, viêm nhiễm.",{"VOID":2578},"2119001",{"VOID":2580},"W2191654227",{"EN":2582,"VI":2583},"\u003Cjats:p>In the present study we demonstrate that human monocytes activated by lipopolysaccharides (LPS) were able to produce high levels of interleukin 10 (IL-10), previously designated cytokine synthesis inhibitory factor (CSIF), in a dose dependent fashion. IL-10 was detectable 7 h after activation of the monocytes and maximal levels of IL-10 production were observed after 24-48 h. These kinetics indicated that the production of IL-10 by human monocytes was relatively late as compared to the production of IL-1 alpha, IL-1 beta, IL-6, IL-8, tumor necrosis factor alpha (TNF alpha), and granulocyte colony-stimulating factor (G-CSF), which were all secreted at high levels 4-8 h after activation. The production of IL-10 by LPS activated monocytes was, similar to that of IL-1 alpha, IL-1 beta, IL-6, IL-8, TNF alpha, granulocyte-macrophage colony-stimulating factor (GM-CSF), and G-CSF, inhibited by IL-4. Furthermore we demonstrate here that IL-10, added to monocytes, activated by interferon gamma (IFN-gamma), LPS, or combinations of LPS and IFN-gamma at the onset of the cultures, strongly inhibited the production of IL-1 alpha, IL-1 beta, IL-6, IL-8, TNF alpha, GM-CSF, and G-CSF at the transcriptional level. Viral-IL-10, which has similar biological activities on human cells, also inhibited the production of TNF alpha and GM-CSF by monocytes following LPS activation. Activation of monocytes by LPS in the presence of neutralizing anti-IL-10 monoclonal antibodies resulted in the production of higher amounts of cytokines relative to LPS treatment alone, indicating that endogenously produced IL-10 inhibited the production of IL-1 alpha, IL-1 beta, IL-6, IL-8, TNF alpha, GM-CSF, and G-CSF. In addition, IL-10 had autoregulatory effects since it strongly inhibited IL-10 mRNA synthesis in LPS activated monocytes. Furthermore, endogenously produced IL-10 was found to be responsible for the reduction in class II major histocompatibility complex (MHC) expression following activation of monocytes with LPS. Taken together our results indicate that IL-10 has important regulatory effects on immunological and inflammatory responses because of its capacity to downregulate class II MHC expression and to inhibit the production of proinflammatory cytokines by monocytes.\u003C\u002Fjats:p>","\u003Cjats:p>Nghiên cứu hiện tại chứng minh rằng bạch cầu đơn nhân người được kích hoạt bằng lipopolysaccharides (LPS) có khả năng sản xuất mức cao interleukin 10 (IL-10), trước đây được gọi là yếu tố ức chế tổng hợp cytokine (CSIF), phụ thuộc vào liều lượng. IL-10 có thể được phát hiện 7 giờ sau khi kích hoạt bạch cầu đơn nhân và mức tối đa của sự sản xuất IL-10 được quan sát sau 24-48 giờ. Những động học này chỉ ra rằng việc sản xuất IL-10 bởi bạch cầu đơn nhân người tương đối muộn so với sự sản xuất IL-1 alpha, IL-1 beta, IL-6, IL-8, yếu tố hoại tử khối u alpha (TNF alpha), và yếu tố kích thích thuộc địa bạch cầu trung tính (G-CSF), tất cả đều được tiết ra ở mức cao từ 4-8 giờ sau khi kích hoạt. Việc sản xuất IL-10 bởi bạch cầu đơn nhân được kích hoạt bởi LPS, tương tự như của IL-1 alpha, IL-1 beta, IL-6, IL-8, TNF alpha, yếu tố kích thích thuộc địa bạch cầu đại thực bào (GM-CSF), và G-CSF, bị ức chế bởi IL-4. Hơn nữa, chúng tôi chứng minh rằng IL-10, được thêm vào bạch cầu đơn nhân, khi được kích hoạt bởi interferon gamma (IFN-gamma), LPS, hoặc các tổ hợp của LPS và IFN-gamma vào đầu giai đoạn nuôi cấy, giảm mạnh sản xuất IL-1 alpha, IL-1 beta, IL-6, IL-8, TNF alpha, GM-CSF, và G-CSF ở mức phiên mã. Viral-IL-10, với các hoạt động sinh học tương tự trên tế bào người, cũng ức chế sản xuất TNF alpha và GM-CSF bởi bạch cầu đơn nhân sau khi kích hoạt LPS. Kích hoạt bạch cầu đơn nhân bằng LPS với sự hiện diện của các kháng thể đơn dòng trung hòa anti-IL-10 dẫn đến sản xuất một lượng cytokine lớn hơn so với điều trị chỉ với LPS, chỉ ra rằng IL-10 được sản xuất nội sinh đã ức chế sản xuất IL-1 alpha, IL-1 beta, IL-6, IL-8, TNF alpha, GM-CSF, và G-CSF. Ngoài ra, IL-10 có tác động tự điều hòa vì nó ức chế mạnh mẽ sự tổng hợp mRNA IL-10 trong bạch cầu đơn nhân được kích hoạt bằng LPS. Hơn nữa, IL-10 được sản xuất nội sinh được tìm thấy là chịu trách nhiệm cho việc giảm biểu hiện phức hợp hòa hợp mô chính II (MHC) sau khi bạch cầu đơn nhân được kích hoạt với LPS. 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The majority of PCD seen in higher organisms exhibits strikingly similar morphological features, and this form of PCD has been termed apoptosis. The nature of the PM changes that occur on apoptotic cells remains poorly defined. In this study, we have used a phosphatidylserine (PS)-binding protein (annexin V) as a specific probe to detect redistribution of this phospholipid, which is normally confined to the inner PM leaflet, during apoptosis. Here we show that PS externalization is an early and widespread event during apoptosis of a variety of murine and human cell types, regardless of the initiating stimulus, and precedes several other events normally associated with this mode of cell death. We also report that, under conditions in which the morphological features of apoptosis were prevented (macromolecular synthesis inhibition, overexpression of Bcl-2 or Abl), the appearance of PS on the external leaflet of the PM was similarly prevented. These data are compatible with the notion that activation of an inside-outside PS translocase is an early and widespread event during apoptosis.\u003C\u002Fjats:p>","\u003Cjats:p>Một sự kiện quan trọng trong quá trình chết tế bào được lập trình (PCD) dường như là sự thay đổi màng plasma (PM) cho phép các tế bào thực bào nhận ra và bao vây những tế bào này trước khi chúng vỡ ra. Phần lớn các trường hợp PCD được quan sát ở các sinh vật bậc cao cho thấy những đặc điểm hình thái tương tự một cách nổi bật, và hình thức PCD này được gọi là apoptosis. Tình trạng thay đổi của màng PM diễn ra trên các tế bào apoptotic vẫn chưa được xác định rõ ràng. Trong nghiên cứu này, chúng tôi đã sử dụng một protein gắn phosphatidylserine (PS) (annexin V) như một công cụ đặc hiệu để phát hiện sự tái phân bố của phospholipid này, thường được giới hạn ở lớp màng trong của PM, trong quá trình apoptosis. Chúng tôi chứng minh rằng việc xuất hiện PS ra ngoài là một sự kiện sớm và rộng rãi trong quá trình apoptosis của nhiều loại tế bào chuột và người, bất kể kích thích ban đầu là gì, và xuất hiện trước một số sự kiện khác thường liên quan đến chế độ chết tế bào này. Chúng tôi cũng báo cáo rằng, trong các điều kiện mà các đặc điểm hình thái của apoptosis bị ngăn chặn (ức chế tổng hợp đại phân tử, biểu hiện quá mức của Bcl-2 hoặc Abl), sự xuất hiện của PS trên lớp ngoài của PM cũng bị ngăn chặn tương tự. Dữ liệu này tương thích với giả thuyết rằng việc kích hoạt một translocase PS từ trong ra ngoài là một sự kiện sớm và phổ biến trong quá trình apoptosis.\u003C\u002Fjats:p>",{"EN":2894,"VI":2895},"Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.","Sự tái phân bố sớm của phosphatidylserine trên màng tế bào là một đặc điểm tổng quát của quá trình apoptosis không phụ thuộc vào kích thích ban đầu: bị ức chế bởi sự biểu hiện quá mức của Bcl-2 và Abl.",{"VOID":2897},"7595224",{"VOID":2899},"10.1084\u002Fjem.182.5.1545",[31],[30],"https:\u002F\u002Frupress.org\u002Fjem\u002Farticle\u002F182\u002F5\u002F1545\u002F25769\u002FEarly-redistribution-of-plasma-membrane",[2904,2923,2940,2955,2972,2987,3002],{"id":2905,"sortIndex":32,"researcher":28,"roles":2906,"affiliations":2907,"properties":2916,"displayName":2920,"givenName":28,"familyName":28},"2ab6e112-636b-453f-a547-a4d26c6c30fe",[],[2908],{"id":2909,"sortIndex":32,"affiliation":2910,"properties":28},"5ac55a5e-ffc2-4370-9b88-2e5b6144220c",{"id":2909,"createTime":28,"updateTime":28,"relativeEntities":2911,"slug":28,"properties":2912,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2915,"statistic":28},[],{"title":2913},{"EN":2914},"Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, California 92037, USA.",[],{"orcid":2917,"title":2919,"openalex":2921},{"VOID":2918},"https:\u002F\u002Forcid.org\u002F0000-0002-8539-3143",{"EN":2920},"Séamus J. 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Immunol., 5, 1461, 10.1093\u002Fintimm\u002F5.11.1461",{"doi":3406},"10.1093\u002Fintimm\u002F5.11.1461",{"id":28,"text":1975,"url":28,"identifiers":3408},{"doi":1977},{"id":28,"text":3410,"url":28,"identifiers":3411},"2001, Nucleic Acids Res., 29, e45, 10.1093\u002Fnar\u002F29.9.e45",{"doi":3412},"10.1093\u002Fnar\u002F29.9.e45",{"id":3414,"createTime":3415,"updateTime":3416,"relativeEntities":3417,"slug":3418,"properties":3419,"entityType":1159,"verifyStatus":26,"verifyTime":3437,"verifyNote":1161,"languages":3438,"translateLanguages":3439,"viewCount":32,"primaryUrl":3440,"fullTextUrl":28,"authors":3441,"publicationType":1477,"publisherRelationship":3489,"citationCount":1001,"citationInfo":3547,"publishDate":3550,"publishYear":3548,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":3551,"openAccess":28,"references":3552,"isForceReanalyzing":1665},"7d635b41-42ac-405b-9b6c-a04fbb479e3e","2024-09-19T06:48:06.514+00:00","2025-02-24T11:47:51.997+00:00",[],"SURFACE-MARKERS-ON-HUMAN-T-AND-B-LYMPHOCYTES",{"mag":3420,"keywords":3422,"pmc":3423,"openalex":3425,"abstract":3427,"title":3430,"pm":3433,"doi":3435},{"VOID":3421},"1977602326",{"VI":1144},{"VOID":3424},"2139198",{"VOID":3426},"W1977602326",{"EN":3428,"VI":3429},"\u003Cjats:p>By using the two criteria (a) high density of immunoglobulin determinants on the cell surface and (b) presence of receptors for C'3 on the cell surface for defining bone marrow-derived lymphocytes, it is indirectly shown that all or at least a major population of human thymus-derived lymphocytes under certain conditions will form nonimmune rosettes with sheep red blood cells (SRBC). Almost all thymocytes tested from two different donors formed rosettes. The SRBC rosettes are not formed by virtue of immunoglobulin receptors and form only around living cells. Positive bivalent ions are required for rosette formation since EDTA will block rosette formation. Sodium iodoacetate will also block rosette formation demonstrating the dependence on an intact glycolytic pathway. Rosette formation is temperature dependent and will not appear at 37°C. Trypsin treatment of lymphocytes will abolish their SRBC-binding ability which cannot be restored by treating them with fresh donor serum or fetal calf serum, but which will reappear after culturing the lymphocytes. 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Natri iodoacetate cũng sẽ chặn việc hình thành vòng, điều này cho thấy sự phụ thuộc vào một con đường glyco-lytic không bị tổn thương. Việc hình thành vòng phụ thuộc vào nhiệt độ và sẽ không xuất hiện ở 37°C. Việc điều trị bằng trypsin đối với các tế bào lympho sẽ loại bỏ khả năng gắn kết với SRBC, điều này không thể được phục hồi bằng cách điều trị chúng với huyết thanh người cho tươi hoặc huyết thanh bê thai, nhưng sẽ tái xuất hiện sau khi nuôi cấy các tế bào lympho. 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methods were used to demonstrate the presence of tumor-specific antigens in adenocarcinomata of the human colon: (a) rabbits were immunized with extracts of pooled colonic carcinomata, and the antitumor antisera thus produced were absorbed with a pooled extract of normal human colon and with human blood components; (b) newborn rabbits were made immunologically tolerant to normal colonic tissue at birth, and were then immunized with pooled tumor material in adult life. 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Mô bình thường và mô khối u được lấy từ cùng một người hiến tặng nhằm tránh sự hiểu nhầm về kết quả do sự khác biệt về kháng nguyên đặc hiệu của từng cá nhân.\u003C\u002Fjats:p>\n               \u003Cjats:p>Huyết thanh chuẩn bị bởi cả hai phương pháp đã được thử nghiệm đối với các kháng nguyên bình thường và khối u bằng các kỹ thuật khuếch tán gel agar, điện di miễn dịch, ngưng kết hồng cầu, PCA và miễn dịch huỳnh quang. Hoạt tính kháng thể rõ rệt nhắm vào ít nhất hai kháng nguyên đặc hiệu tumor chất lượng đã được phát hiện trong huyết thanh được chuẩn bị bởi cả hai phương pháp và ít nhất hai kháng nguyên khối u bổ sung đã được phát hiện độc quyền trong huyết thanh được chuẩn bị theo kỹ thuật dung nạp. Liệu các kháng nguyên bổ sung này có khác biệt chất lượng so với kháng nguyên mô bình thường, hoặc chỉ tồn tại trong mô khối u với nồng độ cao hơn so với mô bình thường vẫn chưa được xác định. Hơn nữa, đã chỉ ra rằng các kháng thể đặc hiệu tumor không nhắm vào các chất bẩn vi khuẩn hoặc vào nồng độ cao bất thường của fibrin có trong nhiều mô u ác tính.\u003C\u002Fjats:p>\n               \u003Cjats:p>Các kết quả từ những nghiên cứu này đã kết luận rằng các chiết xuất khối u tổng hợp chứa các kháng nguyên đặc hiệu tumor không có trong mô đại tràng bình thường. 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