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Patients were matched 1:20 with controls by gender and age (±2 years) from a large screening colonoscopy database. The baseline, colonoscopic and clinicopathological characteristics of patients with \u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">S\u003C\u002Fjats:styled-content>. bovis\u003C\u002Fjats:italic> endocarditis were analyzed.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>From 1996 to 2010, 18 adult patients with \u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">S\u003C\u002Fjats:styled-content>. bovis\u003C\u002Fjats:italic> bacteremia were identified, of whom 10 with infective endocarditis (\u003Cjats:styled-content style=\"fixed-case\">IE\u003C\u002Fjats:styled-content>) underwent colonoscopic evaluation. Endocarditis involved a native or prosthetic valve in six and four of those patients, respectively. All 10 patients recovered without recurrence of \u003Cjats:styled-content style=\"fixed-case\">IE\u003C\u002Fjats:styled-content> (mean follow‐up duration 49.6 months). None had a concurrent or preceding history of colon disease and only one had subclinical chronic liver disease. Advanced neoplasia, defined as the presence of polyps ≥1 cm (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 6), villous histology (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 3), high‐grade focal dysplasia (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 1) or cancer (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 1), was found under colonoscopy in 6 of the 10 cases (60.0%) compared with 13\u002F200 (6.5%) matched controls (\u003Cjats:styled-content style=\"fixed-case\">OR\u003C\u002Fjats:styled-content> 21.6, 95% \u003Cjats:styled-content style=\"fixed-case\">CI\u003C\u002Fjats:styled-content> 5.4–86.1, \u003Cjats:italic>P\u003C\u002Fjats:italic> < 0.0001).\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>\u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">S\u003C\u002Fjats:styled-content>. bovis\u003C\u002Fjats:italic> endocarditis is strongly associated with the presence of advanced colorectal neoplasia. In the absence of any contraindication, colonoscopic examination is strongly recommended in patients with endocarditis. The exact pathophysiological mechanisms underlying this association and the predilection for \u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">S\u003C\u002Fjats:styled-content>. bovis\u003C\u002Fjats:italic> bacteremia in patients with advanced colonic neoplasia remain unclear.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":101},"Association of \u003Ci>\u003Cscp>S\u003C\u002Fscp>treptococcus bovis\u003C\u002Fi> endocarditis and advanced colorectal neoplasia: A case–control study",{"VOID":103},"23551389",{"VOID":105},"10.1111\u002F1751-2980.12059","PUBLICATION","VERIFIED","2025-02-03T20:35:36.735+00:00","Auto Verify",[111],"EN","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002F1751-2980.12059",[114,133,149,165,183,201,217],{"id":115,"sortIndex":25,"researcher":24,"roles":116,"affiliations":117,"properties":126,"displayName":130,"givenName":24,"familyName":24},"1e9855bd-c8ce-4709-a414-3c589fccc93f",[],[118],{"id":119,"sortIndex":25,"affiliation":120,"properties":24},"ce529c7e-ebeb-4fd9-9261-8f1564ec65bb",{"id":119,"createTime":24,"updateTime":24,"relativeEntities":121,"slug":24,"properties":122,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":125,"statistic":24},[],{"title":123},{"VI":124},"Division of Gastroenterology, American University of Beirut Medical Center, Beirut, Lebanon",[],{"orcid":127,"title":129,"openalex":131},{"VOID":128},"https:\u002F\u002Forcid.org\u002F0000-0003-0248-9527",{"EN":130},"Ala I. 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Nghiên cứu này nhằm đánh giá hiệu quả và độ an toàn của ESD cho LST‐DL.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Phương pháp\u003C\u002Fjats:title>\u003Cjats:p>Các bệnh nhân liên tiếp có LST‐DL đã trải qua ESD tại bệnh viện của chúng tôi từ tháng 1 năm 2010 đến tháng 12 năm 2015 đã được ghi nhận hồi cứu trong nghiên cứu này. Tỷ lệ cắt bỏ \u003Cjats:italic>en bloc\u003C\u002Fjats:italic>, tỷ lệ cắt bỏ R0, các biến chứng, đặc điểm bệnh lý và tái phát khối u đã được phân tích và so sánh với các LST trong trực tràng không liên quan đến đường răng cưa (LST‐NDL).\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Kết quả\u003C\u002Fjats:title>\u003Cjats:p>Tổng cộng có 49 bệnh nhân với LST‐DL (tuổi trung bình 63 tuổi; 39 nữ; kích thước tổn thương trung bình 57 mm; thời gian theo dõi trung bình 24 tháng) và 96 bệnh nhân với LST‐NDL (tuổi trung bình 67 tuổi; 31 nữ; kích thước tổn thương trung bình 47 mm; thời gian theo dõi trung bình 31 tháng) đã được ghi nhận. Tỷ lệ cắt bỏ \u003Cjats:italic>en bloc\u003C\u002Fjats:italic> (93.9% [46\u002F49] so với 94.8% [91\u002F96]) và tỷ lệ cắt bỏ \u003Cjats:italic>en bloc\u003C\u002Fjats:italic> R0 (83.7% [41\u002F49] so với 88.5% [85\u002F96]) cho LST‐DL và LST‐NDL, không có sự khác biệt đáng kể. Tuy nhiên, ESD cho LST‐DL có thời gian thực hiện lâu hơn (77 phút so với 54 phút, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.02), tỷ lệ đau quanh hậu môn sau thủ thuật cao hơn (28.6% so với 0%, \u003Cjats:italic>P\u003C\u002Fjats:italic> < 0.001), và nhiều trường hợp hẹp hậu môn hơn (4.1% so với 0%, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.04). Tỷ lệ biến chứng như thủng, chảy máu và sốt, tỷ lệ tái phát, và các đặc điểm bệnh lý không có sự khác biệt giữa hai nhóm.","\u003Cjats:sec>\u003Cjats:title>Objective\u003C\u002Fjats:title>\u003Cjats:p>Endoscopic submucosal dissection (ESD) for laterally spreading tumors (LST) involving the dentate line (LST‐DL) is challenging because of the specific anatomical features of the anorectum. This study aimed to evaluate the efficacy and safety of ESD for LST‐DL.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>Consecutive patients with LST‐DL who had undergone ESD at our hospital between January 2010 and December 2015 were retrospectively enrolled in this study. Rates of \u003Cjats:italic>en bloc\u003C\u002Fjats:italic> resection, R0 resection, and complications, pathological characteristics, and tumor recurrence were analyzed and compared with those of LST in the rectum not involving the dentate line (LST‐NDL).\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Altogether 49 patients with LST‐DL (median age 63 years; 39 women; median lesion size 57 mm; median follow‐up period of 24 months) and 96 patients with LST‐NDL (median age 67 years; 31 women; median lesion size 47 mm; median follow‐up period of 31 months) were enrolled. \u003Cjats:italic>En bloc\u003C\u002Fjats:italic> resection (93.9% [46\u002F49] vs 94.8% [91\u002F96]) and \u003Cjats:italic>en bloc\u003C\u002Fjats:italic> R0 resection rates (83.7% [41\u002F49] vs 88.5% [85\u002F96]), respectively, for LST‐DL and LST‐NDL, with no significant differences. However, ESD for LST‐DL had a longer procedure time (77 min vs 54 min, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.02), a greater postprocedural perianal pain rate (28.6% vs 0%, \u003Cjats:italic>P\u003C\u002Fjats:italic> < 0.001), and more anal strictures (4.1% vs 0%, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.04). The complication rates of perforation, bleeding and fever, recurrence rate, and pathological characteristics did not differ between the two groups.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>ESD is a safe and effective therapeutic modality for LST‐DL. 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G, 2011, The Cooperative Italian FLIN Study Group: prevalence and clinico‐pathological features of colorectal laterally spreading tumors, Endoscopy., 43, 856, 10.1055\u002Fs-0030-1256639",{"doi":638},"10.1055\u002Fs-0030-1256639",{"id":24,"text":640,"url":24,"identifiers":641},"10.1016\u002Fj.cgh.2011.03.018",{"doi":640},{"id":24,"text":643,"url":24,"identifiers":644},"10.1016\u002FS1470-2045(04)01410-X",{"doi":643},{"id":24,"text":646,"url":24,"identifiers":647},"10.1016\u002Fj.gie.2015.08.043",{"doi":646},{"id":24,"text":649,"url":24,"identifiers":650},"10.1016\u002Fj.gie.2015.08.037",{"doi":649},{"id":24,"text":652,"url":24,"identifiers":653},"10.1016\u002Fj.gie.2010.08.004",{"doi":652},{"id":24,"text":655,"url":24,"identifiers":656},"10.1111\u002Fj.1365-2923.1977.tb00635.x",{"doi":655},{"id":24,"text":658,"url":24,"identifiers":659},"10.1007\u002Fs00464-016-4761-9",{"doi":658},{"id":24,"text":661,"url":24,"identifiers":662},"Imai K, 2015, Safety and efficacy of endoscopic 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Dig Endosc.2015;27(4):417‐434.",{"doi":669},"10.1111\u002Fden.12456",{"id":24,"text":671,"url":24,"identifiers":672},"10.1016\u002Fj.gie.2008.07.052",{"doi":671},{"id":24,"text":674,"url":24,"identifiers":675},"10.1016\u002Fj.gie.2012.04.004",{"doi":674},{"id":24,"text":677,"url":24,"identifiers":678},"10.1007\u002Fs00384-017-2775-y",{"doi":677},{"id":24,"text":680,"url":24,"identifiers":681},"10.1016\u002Fj.gie.2013.07.003",{"doi":680},{"id":24,"text":683,"url":24,"identifiers":684},"10.1055\u002Fs-0030-1255654",{"doi":683},{"id":24,"text":686,"url":24,"identifiers":687},"10.1002\u002Fbjs.18004720602",{"doi":686},{"id":24,"text":689,"url":24,"identifiers":690},"10.1016\u002Fj.gie.2010.06.044",{"doi":689},{"id":692,"createTime":693,"updateTime":694,"relativeEntities":695,"slug":696,"properties":697,"entityType":106,"verifyStatus":107,"verifyTime":714,"verifyNote":109,"languages":715,"translateLanguages":716,"viewCount":25,"primaryUrl":717,"fullTextUrl":24,"authors":718,"publicationType":237,"publisherRelationship":819,"citationCount":865,"citationInfo":866,"publishDate":869,"publishYear":867,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":870,"openAccess":24,"references":871,"isForceReanalyzing":364},"e8e3e5a6-4731-40a5-a748-5291242e0d60","2024-11-26T10:44:39.624+00:00","2025-01-05T09:49:56.919+00:00",[],"Is-diffusion-weighted-scp-MRI-scp-superior-to-scp-FDG-PET-scp-or-scp-FDG-PET-scp-scp-CT-scp-in-evaluating-and-predicting-pathological-response-to-preoperative-neoadjuvant-therapy-in-patients-with-rectal-cancer-",{"mag":698,"keywords":700,"openalex":702,"abstract":704,"title":707,"pm":710,"doi":712},{"VOID":699},"2147633390",{"VI":701},"",{"VOID":703},"W2147633390",{"VI":705,"EN":706},"\u003Cjats:sec>\u003Cjats:title>Mục tiêu\u003C\u002Fjats:title>\u003Cjats:p>Nghiên cứu tổng hợp này nhằm so sánh độ chính xác chẩn đoán của hình ảnh cộng hưởng từ khuếch tán (DW-MRI) và chụp positron phát ra từ fluorodeoxyglucose (FDG-PET) hoặc FDG-PET\u002Fcắt lớp vi tính (CT) trong việc đánh giá và dự đoán phản ứng bệnh lý đối với liệu pháp hóa xạ trị bổ trợ trước phẫu thuật (NCRT) ở bệnh nhân ung thư trực tràng.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Phương pháp\u003C\u002Fjats:title>\u003Cjats:p>Một nghiên cứu tài liệu toàn diện đã được thực hiện để xác định các nghiên cứu liên quan cho tổng hợp này. Độ nhạy tổng hợp, độ đặc hiệu, giá trị tiên đoán dương tính (PPV) và giá trị tiên đoán âm tính (NPV) đã được tính toán.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Kết quả\u003C\u002Fjats:title>\u003Cjats:p>Tổng cộng có 33 nghiên cứu với 1564 bệnh nhân đáp ứng tiêu chí bao gồm. Độ nhạy tổng hợp (81% [95% CI 74–86%] so với 85% [95% CI 75–91%]) và NPV (80% [95% CI 68–89%] so với 91% [95% CI 80–95%]) của FDG-PET hoặc FDG-PET\u002FCT thấp hơn đáng kể so với DW-MRI (P \u003C 0.05). Không có sự khác biệt nào được quan sát thấy ở độ đặc hiệu và PPV tổng hợp giữa DW-MRI và FDG-PET hoặc FDG-PET\u002FCT. Phân tích nhóm thêm cho thấy DW-MRI có độ nhạy cao hơn khi chỉ xem xét các khối u tuyến so với các khối u có bao gồm cả khối u tuyến nhầy (92% [95% CI 83–99%] so với 76% [95% CI 63–90%], P = 0.00).\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Kết luận\u003C\u002Fjats:title>\u003Cjats:p>DW-MRI vượt trội hơn FDG-PET hoặc FDG-PET\u002FCT trong việc dự đoán và đánh giá các phản ứng bệnh lý đối với liệu pháp NCRT trước phẫu thuật ở bệnh nhân ung thư trực tràng. Tuy nhiên, độ đặc hiệu và PPV tương đối thấp của nó hạn chế ứng dụng trong thực hành lâm sàng, khiến nó không phù hợp để theo dõi bệnh nhân, đặc biệt là những bệnh nhân có khối u tuyến nhầy trực tràng.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>","\u003Cjats:sec>\u003Cjats:title>Objective\u003C\u002Fjats:title>\u003Cjats:p>This meta‐analysis aimed to compare the diagnostic accuracy of diffusion‐weighted magnetic resonance imaging (\u003Cjats:styled-content style=\"fixed-case\">DW‐MRI\u003C\u002Fjats:styled-content>) and fluorodeoxyglucose‐positron emission tomography (\u003Cjats:styled-content style=\"fixed-case\">FDG‐PET\u003C\u002Fjats:styled-content>) or FDG‐PET\u002Fcomputed tomography (\u003Cjats:styled-content style=\"fixed-case\">CT\u003C\u002Fjats:styled-content>) in evaluating and predicting pathological response to preoperative neoadjuvant chemoradiotherapy (\u003Cjats:styled-content style=\"fixed-case\">NCRT)\u003C\u002Fjats:styled-content> in patients with rectal cancer.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>A comprehensive literature research was conducted to identify the relevant studies for this meta‐analysis. Combined sensitivity, specificity, positive (\u003Cjats:styled-content style=\"fixed-case\">PPV\u003C\u002Fjats:styled-content>) and negative predictive values (\u003Cjats:styled-content style=\"fixed-case\">NPV\u003C\u002Fjats:styled-content>) were calculated.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>A total of 33 studies including 1564 patients met the inclusion criteria. The pooled sensitivity (81% [95% \u003Cjats:styled-content style=\"fixed-case\">CI\u003C\u002Fjats:styled-content> 74–86%] \u003Cjats:italic>vs\u003C\u002Fjats:italic> 85% [95% \u003Cjats:styled-content style=\"fixed-case\">CI\u003C\u002Fjats:styled-content> 75–91%]) and \u003Cjats:styled-content style=\"fixed-case\">NPV\u003C\u002Fjats:styled-content> (80% [95% \u003Cjats:styled-content style=\"fixed-case\">CI\u003C\u002Fjats:styled-content> 68–89%] \u003Cjats:italic>vs\u003C\u002Fjats:italic> 91% [95% \u003Cjats:styled-content style=\"fixed-case\">CI\u003C\u002Fjats:styled-content> 80–95%]) for \u003Cjats:styled-content style=\"fixed-case\">FDG‐PET\u003C\u002Fjats:styled-content> or \u003Cjats:styled-content style=\"fixed-case\">FDG‐PET\u002FCT\u003C\u002Fjats:styled-content> were significantly lower than those for \u003Cjats:styled-content style=\"fixed-case\">DW‐MRI\u003C\u002Fjats:styled-content> (\u003Cjats:italic>P\u003C\u002Fjats:italic> < 0.05). No differences were observed in pooled specificity and \u003Cjats:styled-content style=\"fixed-case\">PPV\u003C\u002Fjats:styled-content> between \u003Cjats:styled-content style=\"fixed-case\">DW‐MRI\u003C\u002Fjats:styled-content> and \u003Cjats:styled-content style=\"fixed-case\">FDG‐PET\u003C\u002Fjats:styled-content> or \u003Cjats:styled-content style=\"fixed-case\">FDG‐PET\u002FCT\u003C\u002Fjats:styled-content>. Further subgroup analyses showed that \u003Cjats:styled-content style=\"fixed-case\">DW‐MRI\u003C\u002Fjats:styled-content> had higher sensitivity on adenocarcinomas alone than on those including mucinous‐type adenocarcinomas (92% [95% \u003Cjats:styled-content style=\"fixed-case\">CI\u003C\u002Fjats:styled-content> 83–99%] \u003Cjats:italic>vs\u003C\u002Fjats:italic> 76% [95% \u003Cjats:styled-content style=\"fixed-case\">CI\u003C\u002Fjats:styled-content> 63–90%], \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.00).\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>\u003Cjats:styled-content style=\"fixed-case\">DW‐MRI\u003C\u002Fjats:styled-content> is superior to \u003Cjats:styled-content style=\"fixed-case\">FDG‐PET\u003C\u002Fjats:styled-content> or \u003Cjats:styled-content style=\"fixed-case\">FDG‐PET\u002FCT\u003C\u002Fjats:styled-content> in predicting and evaluating pathological responses to preoperative \u003Cjats:styled-content style=\"fixed-case\">NCRT\u003C\u002Fjats:styled-content> in patients with rectal cancer. However, its relatively low specificity and \u003Cjats:styled-content style=\"fixed-case\">PPV\u003C\u002Fjats:styled-content> limit its application in clinic, making it currently inappropriate to monitor such patients, especially those with mucinous‐type rectal adenocarcinomas.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":708,"VI":709},"Is diffusion‐weighted \u003Cscp>MRI\u003C\u002Fscp> superior to \u003Cscp>FDG‐PET\u003C\u002Fscp> or \u003Cscp>FDG‐PET\u003C\u002Fscp>\u002F\u003Cscp>CT\u003C\u002Fscp> in evaluating and predicting pathological response to preoperative neoadjuvant therapy in patients with rectal cancer?","Liệu chụp cộng hưởng từ khuếch tán có ưu thế hơn chụp PET-FDG hoặc PET-FDG\u002FCT trong việc đánh giá và dự đoán phản ứng bệnh lý đối với liệu pháp tiền phẫu ở bệnh nhân ung thư trực 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GL, 2006, 18F‐FDG PET is an early predictor of pathologic tumor response to preoperative radiochemotherapy in locally advanced rectal cancer, J Nucl Med, 47, 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tiêu\u003C\u002Fjats:title>\u003Cjats:p>Nghiên cứu nhằm điều tra mối liên hệ giữa các đa hình gen của yếu tố điều hòa interferon 5 (\u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">IRF5\u003C\u002Fjats:styled-content>\u003C\u002Fjats:italic>) và sự khởi phát của bệnh Crohn (\u003Cjats:styled-content style=\"fixed-case\">CD\u003C\u002Fjats:styled-content>) ở một nhóm nghiên cứu tại Malaysia.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Phương pháp\u003C\u002Fjats:title>\u003Cjats:p>DNA genomic được chiết xuất từ các mẫu máu thu thập từ 91 bệnh nhân \u003Cjats:styled-content style=\"fixed-case\">CD\u003C\u002Fjats:styled-content> và 100 cá nhân khỏe mạnh thông qua phương pháp chiết xuất phenol-chloroform truyền thống. Việc sàng lọc bốn đa hình nucleotide đơn (SNPs) mục tiêu, bao gồm rs3807306, rs4728142, rs10954213 và rs11770589 được thực hiện trong máy khuếch đại vòng polymerase thời gian thực (\u003Cjats:styled-content style=\"fixed-case\">PCR\u003C\u002Fjats:styled-content>) bằng cách sử dụng bộ xét nghiệm phân loại gen \u003Cjats:styled-content style=\"fixed-case\">TaqMan\u003C\u002Fjats:styled-content>. Dữ liệu gen thu được sau đó được phân tích thống kê để liên hệ các \u003Cjats:styled-content style=\"fixed-case\">SNP\u003C\u002Fjats:styled-content> với sự khởi phát của \u003Cjats:styled-content style=\"fixed-case\">CD\u003C\u002Fjats:styled-content> trong quần thể Malaysia. Thí nghiệm phân loại gen và dữ liệu được xác thực một cách chọn lọc bằng cách khuếch đại \u003Cjats:styled-content style=\"fixed-case\">PCR\u003C\u002Fjats:styled-content> thông thường cho các vị trí \u003Cjats:styled-content style=\"fixed-case\">SNP\u003C\u002Fjats:styled-content> và giải trình tự \u003Cjats:styled-content style=\"fixed-case\">DNA\u003C\u002Fjats:styled-content>.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Kết quả\u003C\u002Fjats:title>\u003Cjats:p>Đ allele \u003Cjats:styled-content style=\"fixed-case\">G\u003C\u002Fjats:styled-content> của rs3807306 là yếu tố nguy cơ cho \u003Cjats:styled-content style=\"fixed-case\">CD\u003C\u002Fjats:styled-content> (OR 2.3630, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.00004), trong khi kiểu gen đồng hợp tử \u003Cjats:styled-content style=\"fixed-case\">T\u003C\u002Fjats:styled-content> có tác dụng bảo vệ chống lại bệnh (OR 0.2038, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.00004). Kiểu gen dị hợp tử \u003Cjats:styled-content style=\"fixed-case\">A\u002FG\u003C\u002Fjats:styled-content> của rs10954213 có sự liên kết đáng kể với \u003Cjats:styled-content style=\"fixed-case\">CD\u003C\u002Fjats:styled-content> (OR 4.319, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.0377). Mặt khác, kiểu gen đồng hợp tử \u003Cjats:styled-content style=\"fixed-case\">A\u003C\u002Fjats:styled-content> và kiểu gen dị hợp tử \u003Cjats:styled-content style=\"fixed-case\">A\u002FG\u003C\u002Fjats:styled-content> của rs11770589 có ý nghĩa ở nhóm đối chứng (OR 0.4242, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.0166) và bệnh nhân (OR 2.000, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.0179), tương ứng. Trong phân tích phân tầng sắc tộc, kiểu gen đồng hợp tử A của rs11770589 có tác dụng bảo vệ ở người Ấn Độ (OR 0.1551, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.0112).\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Kết luận\u003C\u002Fjats:title>\u003Cjats:p>Các đa hình gen \u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">IRF5\u003C\u002Fjats:styled-content>\u003C\u002Fjats:italic> có thể đóng vai trò trong sự phát triển của \u003Cjats:styled-content style=\"fixed-case\">CD\u003C\u002Fjats:styled-content> ở quần thể Malaysia.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>","\u003Cjats:sec>\u003Cjats:title>Objective\u003C\u002Fjats:title>\u003Cjats:p>The study aimed to investigate the association between the interferon regulatory factor 5 (\u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">IRF5\u003C\u002Fjats:styled-content>\u003C\u002Fjats:italic>) gene polymorphisms and the onset of \u003Cjats:styled-content style=\"fixed-case\">C\u003C\u002Fjats:styled-content>rohn's disease (\u003Cjats:styled-content style=\"fixed-case\">CD\u003C\u002Fjats:styled-content>) in a \u003Cjats:styled-content style=\"fixed-case\">M\u003C\u002Fjats:styled-content>alaysian cohort.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>Genomic \u003Cjats:styled-content style=\"fixed-case\">DNA\u003C\u002Fjats:styled-content> was extracted from blood samples collected from 91 \u003Cjats:styled-content style=\"fixed-case\">CD\u003C\u002Fjats:styled-content> patients and 100 healthy individuals via a conventional phenol‐chloroform extraction method. Screening of the four target single nucleotide polymorphisms (SNPs), including rs3807306, rs4728142, rs10954213 and rs11770589 was carried out in a real‐time polymerase chain reaction (\u003Cjats:styled-content style=\"fixed-case\">PCR\u003C\u002Fjats:styled-content>) thermal cycler using \u003Cjats:styled-content style=\"fixed-case\">TaqMan\u003C\u002Fjats:styled-content> genotyping assay. The genetic data obtained was subsequently subjected to statistical analysis to relate the \u003Cjats:styled-content style=\"fixed-case\">SNP\u003C\u002Fjats:styled-content>s to the onset of \u003Cjats:styled-content style=\"fixed-case\">CD\u003C\u002Fjats:styled-content> in the \u003Cjats:styled-content style=\"fixed-case\">M\u003C\u002Fjats:styled-content>alaysian population. The genotyping assay and data were further validated selectively by conventional \u003Cjats:styled-content style=\"fixed-case\">PCR\u003C\u002Fjats:styled-content> amplification of the \u003Cjats:styled-content style=\"fixed-case\">SNP\u003C\u002Fjats:styled-content> sites and \u003Cjats:styled-content style=\"fixed-case\">DNA\u003C\u002Fjats:styled-content> sequencing.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>The rs3807306 \u003Cjats:styled-content style=\"fixed-case\">G\u003C\u002Fjats:styled-content> allele was a risk factor for \u003Cjats:styled-content style=\"fixed-case\">CD\u003C\u002Fjats:styled-content> (OR 2.3630, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.00004), whereas the homozygous \u003Cjats:styled-content style=\"fixed-case\">T\u003C\u002Fjats:styled-content> genotype was protective against the disease (OR 0.2038, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.00004). The heterozygous \u003Cjats:styled-content style=\"fixed-case\">A\u002FG\u003C\u002Fjats:styled-content> genotype of rs10954213 was significantly associated with CD (OR 4.319, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.0377). On the other hand, the homozygous \u003Cjats:styled-content style=\"fixed-case\">A\u003C\u002Fjats:styled-content> and heterozygous \u003Cjats:styled-content style=\"fixed-case\">A\u002FG\u003C\u002Fjats:styled-content> genotypes of the rs11770589 were significant in the controls (OR 0.4242, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.0166) and patients (OR 2.000, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.0179), respectively. In the ethnic‐stratification analysis, the rs11770589 homozygous A genotype was protective in Indians (OR 0.1551, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.0112).\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusion\u003C\u002Fjats:title>\u003Cjats:p>\u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">IRF5\u003C\u002Fjats:styled-content>\u003C\u002Fjats:italic> gene polymorphisms may play a role in the development of \u003Cjats:styled-content style=\"fixed-case\">CD\u003C\u002Fjats:styled-content> in the Malaysian population.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":1057,"VI":1058},"Association between genetic polymorphisms in interferon regulatory factor 5 (\u003Ci>IRF5\u003C\u002Fi>) gene and \u003Cscp>M\u003C\u002Fscp>alaysian patients with \u003Cscp>C\u003C\u002Fscp>rohn's disease","Mối liên hệ giữa các đa hình gen trong gene yếu tố điều hòa interferon 5 (\u003Ci>IRF5\u003C\u002Fi>) và bệnh Crohn ở bệnh nhân 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thư thực quản, nguyên nhân thứ sáu phổ biến nhất gây tử vong do ung thư trên toàn thế giới, bao gồm các loại mô học khác nhau và thể hiện các mẫu tỷ lệ mắc bệnh đa dạng. Ung thư biểu mô tuyến thực quản và ung thư biểu mô tế bào vảy thực quản là hai loại phổ biến nhất. Các nghiên cứu dịch tễ học đã chỉ ra rằng việc tiêu thụ các chất nóng là một yếu tố nguy cơ chính đối với ung thư biểu mô tế bào vảy, do đó việc đánh giá tác động của áp lực bên ngoài này lên tế bào thực quản là điều cần thiết. Loại áp lực này gây ra những thay đổi tế bào và làm ổn định chúng bằng cách ảnh hưởng đến các đặc điểm tế bào khác nhau như tính ổn định di truyền, tính toàn vẹn của màng và sự điều hòa của các con đường tín hiệu. Nó cũng gây tổn thương mô bằng cách ảnh hưởng đến ma trận ngoại bào và khả năng sống sót của tế bào. Do đó, một trong những hậu quả chính của tổn thương nhiệt là sự kích hoạt hệ thống miễn dịch, có thể dẫn đến viêm mãn tính. Sự thay đổi di truyền xảy ra trong quá trình tổn thương nhiệt và sự giảm chức năng của các hệ thống sửa chữa được củng cố thêm bởi viêm mãn tính, do đó tăng khả năng xuất hiện các dòng tế bào đột biến. Các phân tử có mặt trong hoàn cảnh này, chẳng hạn như protein sốc nhiệt, cytokine, chemokine và các yếu tố viêm khác, ảnh hưởng đến các con đường tín hiệu liên tế bào, bao gồm yếu tố nhân kappa‐light‐chain‐enhancer của tế bào B hoạt hóa, người truyền đạt tín hiệu kích hoạt phiên mã‐3 và yếu tố gây thiếu oxy 1α trong việc hỗ trợ sự sống sót và sự xuất hiện của các kiểu hình đột biến cũng như sự tiến triển ác tính tiếp theo trong các dòng tế bào bị thay đổi. Cuộc điều tra về các yếu tố hiệu quả này và vai trò có thể của chúng trong con đường sinh ung thư có thể cải thiện hiểu biết hiện tại.","\u003Cjats:p>Esophageal cancer, the sixth most common cause of death from cancer worldwide, consists of different histological types and displays various patterns of incidence. Esophageal adenocarcinoma and esophageal squamous cell carcinoma are the most prevalent types. As epidemiological studies report that ingesting hot substances is one major risk factor for squamous cell carcinoma, evaluating the effect of this external stress on esophagus cells seems desirable. This specific kind of stress brings about cellular changes and stabilizes them by affecting different cellular features such as genetic stability, membrane integrity and the regulation of signaling pathways. It also causes tissue injury by affecting the extracellular matrix and cell viability. Thus, one of the main consequences of thermal injury is the activation of the immune system, which can result in chronic inflammation. The genetic alteration that has occurred during thermal injury and the consequent reduction in the function of repair systems is further strengthened by chronic inflammation, thereby increasing the probability that mutated cell lines may appear. The molecules that present in this circumstance, such as heat shock proteins, cytokines, chemokines and other inflammatory factors, affect intercellular signaling pathways, including nuclear factor kappa‐light‐chain‐enhancer of activated B cells, signal transducer activator of transcription‐3 and hypoxia‐inducible factor 1α in supporting the survival and emergence of mutant phenotypes and the consequent malignant progression in altered cell lines. 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tự thực, tế bào biểu mô ruột, vi khuẩn đường ruột, LPS, TEER",{"VOID":1952},"W2099237979",{"VI":1954,"EN":1955},"\u003Cjats:sec>\u003Cjats:title>Mục tiêu\u003C\u002Fjats:title>\u003Cjats:p>Nhằm điều tra tác động của vi khuẩn đường ruột lên việc kích hoạt tự thực (autophagy) trong các tế bào biểu mô ruột (IEC) và đánh giá phản ứng tự thực của IEC đối với các loại \u003Cjats:italic>Bifidobacteria\u003C\u002Fjats:italic> khác nhau.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Phương pháp\u003C\u002Fjats:title>\u003Cjats:p>Các tế bào \u003Cjats:styled-content style=\"fixed-case\">IEC\u003C\u002Fjats:styled-content>-18 được điều trị với lipopolysaccharide (LPS) có nguồn gốc từ \u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">E\u003C\u002Fjats:styled-content>scherichia coli\u003C\u002Fjats:italic> gây bệnh đường ruột (\u003Cjats:styled-content style=\"fixed-case\">EPEC\u003C\u002Fjats:styled-content>) \u003Cjats:styled-content style=\"fixed-case\">O\u003C\u002Fjats:styled-content>127:\u003Cjats:styled-content style=\"fixed-case\">B\u003C\u002Fjats:styled-content>8 và dịch siêu nền của bốn loại \u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">B\u003C\u002Fjats:styled-content>ifidobacteria\u003C\u002Fjats:italic>. Độ kháng điện transepithelial (TEER) được đo bằng một volt-ohmmeter biểu mô. Tự thực được xác định thông qua kính hiển vi điện tử truyền qua (TEM), tỷ lệ của \u003Cjats:styled-content style=\"fixed-case\">LC\u003C\u002Fjats:styled-content>3‐\u003Cjats:styled-content style=\"fixed-case\">II\u003C\u002Fjats:styled-content> so với \u003Cjats:styled-content style=\"fixed-case\">LC\u003C\u002Fjats:styled-content>3‐\u003Cjats:styled-content style=\"fixed-case\">I\u003C\u002Fjats:styled-content> và sự tồn tại của cả tín hiệu protein huỳnh quang xanh (\u003Cjats:styled-content style=\"fixed-case\">GFP\u003C\u002Fjats:styled-content>) và m\u003Cjats:styled-content style=\"fixed-case\">C\u003C\u002Fjats:styled-content>herry sử dụng cấu trúc tandem m\u003Cjats:styled-content style=\"fixed-case\">C\u003C\u002Fjats:styled-content>herry‐\u003Cjats:styled-content style=\"fixed-case\">GFP\u003C\u002Fjats:styled-content>‐\u003Cjats:styled-content style=\"fixed-case\">LC\u003C\u002Fjats:styled-content>3. Sự biểu hiện của phức hợp \u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">A\u003C\u002Fjats:styled-content>tg12–\u003Cjats:styled-content style=\"fixed-case\">A\u003C\u002Fjats:styled-content>tg5–\u003Cjats:styled-content style=\"fixed-case\">A\u003C\u002Fjats:styled-content>tg16\u003C\u002Fjats:italic> được đo bằng phản ứng chuỗi polymerase thời gian thực định lượng.","\u003Cjats:sec>\u003Cjats:title>Objectives\u003C\u002Fjats:title>\u003Cjats:p>To investigate the influence of gut microbiota on autophagy activation in intestinal epithelial cells (\u003Cjats:styled-content style=\"fixed-case\">IEC\u003C\u002Fjats:styled-content>) and to evaluate the IEC autophagy response to different types of \u003Cjats:italic>Bifidobacteria\u003C\u002Fjats:italic>.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>\u003Cjats:styled-content style=\"fixed-case\">IEC\u003C\u002Fjats:styled-content>‐18 cells were treated with lipopolysaccharide (\u003Cjats:styled-content style=\"fixed-case\">LPS\u003C\u002Fjats:styled-content>) derived from enteropathogenic \u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">E\u003C\u002Fjats:styled-content>scherichia coli\u003C\u002Fjats:italic> (\u003Cjats:styled-content style=\"fixed-case\">EPEC\u003C\u002Fjats:styled-content>) \u003Cjats:styled-content style=\"fixed-case\">O\u003C\u002Fjats:styled-content>127:\u003Cjats:styled-content style=\"fixed-case\">B\u003C\u002Fjats:styled-content>8 and culture medium supernatants of four types of \u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">B\u003C\u002Fjats:styled-content>ifidobacteria\u003C\u002Fjats:italic>. Transepithelial electrical resistance (\u003Cjats:styled-content style=\"fixed-case\">TEER\u003C\u002Fjats:styled-content>) was measured using an epithelial voltohmmeter. Autophagy was determined by transmission electron microscopy (\u003Cjats:styled-content style=\"fixed-case\">TEM\u003C\u002Fjats:styled-content>), the ratio of \u003Cjats:styled-content style=\"fixed-case\">LC\u003C\u002Fjats:styled-content>3‐\u003Cjats:styled-content style=\"fixed-case\">II\u003C\u002Fjats:styled-content> to \u003Cjats:styled-content style=\"fixed-case\">LC\u003C\u002Fjats:styled-content>3‐\u003Cjats:styled-content style=\"fixed-case\">I\u003C\u002Fjats:styled-content> and the persistence of both green fluorescent protein (\u003Cjats:styled-content style=\"fixed-case\">GFP\u003C\u002Fjats:styled-content>) and m\u003Cjats:styled-content style=\"fixed-case\">C\u003C\u002Fjats:styled-content>herry signals using a tandem m\u003Cjats:styled-content style=\"fixed-case\">C\u003C\u002Fjats:styled-content>herry‐\u003Cjats:styled-content style=\"fixed-case\">GFP\u003C\u002Fjats:styled-content>‐\u003Cjats:styled-content style=\"fixed-case\">LC\u003C\u002Fjats:styled-content>3 construct. The expression of \u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">A\u003C\u002Fjats:styled-content>tg12–\u003Cjats:styled-content style=\"fixed-case\">A\u003C\u002Fjats:styled-content>tg5–\u003Cjats:styled-content style=\"fixed-case\">A\u003C\u002Fjats:styled-content>tg16\u003C\u002Fjats:italic> complex was measured by quantitative real‐time polymerase chain reaction.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>\u003Cjats:styled-content style=\"fixed-case\">EPEC‐LPS\u003C\u002Fjats:styled-content> significantly diminished the \u003Cjats:styled-content style=\"fixed-case\">TEER\u003C\u002Fjats:styled-content> of \u003Cjats:styled-content style=\"fixed-case\">IEC\u003C\u002Fjats:styled-content> compared with untreated controls by 45–55%. This reduction was not observed after treated with \u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">B\u003C\u002Fjats:styled-content>ifidobacteria\u003C\u002Fjats:italic> at all time points. \u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">B\u003C\u002Fjats:styled-content>ifidobacteria\u003C\u002Fjats:italic> could initiate the activation of autophagy in \u003Cjats:styled-content style=\"fixed-case\">IEC\u003C\u002Fjats:styled-content>, based on both the ratio of LC3‐II to LC3‐I and \u003Cjats:styled-content style=\"fixed-case\">TEM\u003C\u002Fjats:styled-content>. There was no difference in the influence of the four types of \u003Cjats:italic>Bifidobacteria\u003C\u002Fjats:italic> on the autophagy response. Compared with \u003Cjats:italic>Bifidobacteria\u003C\u002Fjats:italic>, \u003Cjats:styled-content style=\"fixed-case\">IEC\u003C\u002Fjats:styled-content> reacted to \u003Cjats:styled-content style=\"fixed-case\">EPEC‐LPS\u003C\u002Fjats:styled-content> much more intensively by autophagy accumulation. More m\u003Cjats:styled-content style=\"fixed-case\">C\u003C\u002Fjats:styled-content>herry\u003Cjats:sup>+\u003C\u002Fjats:sup>\u003Cjats:styled-content style=\"fixed-case\">LC\u003C\u002Fjats:styled-content>3 autophagic puncta and increased expressions of autophagy genes \u003Cjats:italic>Atg5\u003C\u002Fjats:italic>, \u003Cjats:italic>Atg12\u003C\u002Fjats:italic> and \u003Cjats:italic>Atg16\u003C\u002Fjats:italic> could be detected after being treated with \u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">B\u003C\u002Fjats:styled-content>ifidobacteria\u003C\u002Fjats:italic> and \u003Cjats:styled-content style=\"fixed-case\">EPEC‐LPS\u003C\u002Fjats:styled-content>.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>\u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">B\u003C\u002Fjats:styled-content>ifidobacteria\u003C\u002Fjats:italic> initiate autophagy activation in \u003Cjats:styled-content style=\"fixed-case\">IEC\u003C\u002Fjats:styled-content>. 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chứng ruột kích thích, biến thiên nhịp tim, chức năng tự động, rối loạn dây thần kinh phế vị",{"VOID":2296},"W2125087438",{"VI":2298,"EN":2299},"\u003Cjats:sec>\u003Cjats:title>Mục tiêu\u003C\u002Fjats:title>\u003Cjats:p>Phân tích chức năng tự động được thể hiện qua thành phần tần số cao (\u003Cjats:styled-content style=\"fixed-case\">HF\u003C\u002Fjats:styled-content>), một phép đo của giọng dây thần kinh, và tỷ lệ tần số thấp (\u003Cjats:styled-content style=\"fixed-case\">LF\u003C\u002Fjats:styled-content>) so với \u003Cjats:styled-content style=\"fixed-case\">HF\u003C\u002Fjats:styled-content> (LF : HF), một chỉ số của sự cân bằng giữa giao cảm và đối giao cảm ở bệnh nhân hội chứng ruột kích thích (\u003Cjats:styled-content style=\"fixed-case\">IBS\u003C\u002Fjats:styled-content>).\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Phương pháp\u003C\u002Fjats:title>\u003Cjats:p>Chúng tôi đã xác định các nghiên cứu liên quan bằng cách thực hiện tìm kiếm tài liệu trên \u003Cjats:styled-content style=\"fixed-case\">MEDLINE\u003C\u002Fjats:styled-content>, \u003Cjats:styled-content style=\"fixed-case\">EMBASE\u003C\u002Fjats:styled-content> và \u003Cjats:styled-content style=\"fixed-case\">ISI\u003C\u002Fjats:styled-content> Web of Knowledge đến ngày 31 \u003Cjats:styled-content style=\"fixed-case\">M\u003C\u002Fjats:styled-content>arch 2013. Các kích thước hiệu ứng gộp với khoảng tin cậy 95% (\u003Cjats:styled-content style=\"fixed-case\">CI\u003C\u002Fjats:styled-content>) đã được tính toán bằng mô hình hiệu ứng ngẫu nhiên. Sự không đồng nhất giữa các nghiên cứu được đánh giá bằng cách sử dụng test \u003Cjats:styled-content style=\"fixed-case\">Q\u003C\u002Fjats:styled-content> và thống kê \u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">I\u003C\u002Fjats:styled-content>\u003C\u002Fjats:italic>\u003Cjats:sup>2\u003C\u002Fjats:sup>.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Kết quả\u003C\u002Fjats:title>\u003Cjats:p>Tổng cộng có 11 bài báo gồm 392 bệnh nhân \u003Cjats:styled-content style=\"fixed-case\">IBS\u003C\u002Fjats:styled-content> và 263 đối chứng đã đáp ứng tiêu chí bao gồm của phân tích. Bệnh nhân \u003Cjats:styled-content style=\"fixed-case\">IBS\u003C\u002Fjats:styled-content> có công suất băng tần \u003Cjats:styled-content style=\"fixed-case\">HF\u003C\u002Fjats:styled-content> thấp hơn (\u003Cjats:styled-content style=\"fixed-case\">H\u003C\u002Fjats:styled-content>edges's g = −0.38, 95% \u003Cjats:styled-content style=\"fixed-case\">CI\u003C\u002Fjats:styled-content> −0.68 đến −0.09) so với nhóm đối chứng (\u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">I\u003C\u002Fjats:styled-content>\u003C\u002Fjats:italic>\u003Cjats:sup>2\u003C\u002Fjats:sup> = 63.6%, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.003). Hơn nữa, bệnh nhân \u003Cjats:styled-content style=\"fixed-case\">IBS\u003C\u002Fjats:styled-content> cho thấy tỷ lệ \u003Cjats:styled-content style=\"fixed-case\">LF\u003C\u002Fjats:styled-content> : \u003Cjats:styled-content style=\"fixed-case\">HF\u003C\u002Fjats:styled-content> cao hơn (\u003Cjats:styled-content style=\"fixed-case\">H\u003C\u002Fjats:styled-content>edges's g = 0.43, 95% \u003Cjats:styled-content style=\"fixed-case\">CI\u003C\u002Fjats:styled-content> 0.13–0.74), không có sự không đồng nhất đáng kể. Phân tích tiểu nhóm của chỉ số \u003Cjats:styled-content style=\"fixed-case\">HF\u003C\u002Fjats:styled-content> theo thời gian ghi lại cho kết quả khác nhau đối với bệnh nhân \u003Cjats:styled-content style=\"fixed-case\">IBS\u003C\u002Fjats:styled-content> và nhóm đối chứng. Thêm vào đó, bệnh nhân hội chứng ruột kích thích kiểu táo bón (\u003Cjats:styled-content style=\"fixed-case\">IBS\u003C\u002Fjats:styled-content>‐\u003Cjats:styled-content style=\"fixed-case\">C\u003C\u002Fjats:styled-content>) có công suất băng tần \u003Cjats:styled-content style=\"fixed-case\">HF\u003C\u002Fjats:styled-content> giảm, trong khi không tìm thấy sự khác biệt đáng kể ở tỷ lệ \u003Cjats:styled-content style=\"fixed-case\">LF\u003C\u002Fjats:styled-content> : \u003Cjats:styled-content style=\"fixed-case\">HF\u003C\u002Fjats:styled-content>.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Kết luận\u003C\u002Fjats:title>\u003Cjats:p>Chức năng đối giao cảm bị suy giảm và sự mất cân bằng giao cảm – đối giao cảm bất thường có thể liên quan đến sinh bệnh học của \u003Cjats:styled-content style=\"fixed-case\">IBS\u003C\u002Fjats:styled-content>. Rối loạn dây thần kinh phế vị rõ ràng hơn trong tiểu nhóm \u003Cjats:styled-content style=\"fixed-case\">IBS\u003C\u002Fjats:styled-content>‐\u003Cjats:styled-content style=\"fixed-case\">C\u003C\u002Fjats:styled-content>.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>","\u003Cjats:sec>\u003Cjats:title>Objective\u003C\u002Fjats:title>\u003Cjats:p>To analyze autonomic functioning which presented as the high frequency (\u003Cjats:styled-content style=\"fixed-case\">HF\u003C\u002Fjats:styled-content>) component of heart rate variability, a measurement of vagal tone, and the ratio of low frequency (\u003Cjats:styled-content style=\"fixed-case\">LF\u003C\u002Fjats:styled-content>) to \u003Cjats:styled-content style=\"fixed-case\">HF\u003C\u002Fjats:styled-content> (LF : HF), an indicator of sympathovagal balance in irritable bowel syndrome (\u003Cjats:styled-content style=\"fixed-case\">IBS)\u003C\u002Fjats:styled-content> patients.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>We identified relevant studies by performing a literature search of \u003Cjats:styled-content style=\"fixed-case\">MEDLINE\u003C\u002Fjats:styled-content>, \u003Cjats:styled-content style=\"fixed-case\">EMBASE\u003C\u002Fjats:styled-content> and the \u003Cjats:styled-content style=\"fixed-case\">ISI\u003C\u002Fjats:styled-content> Web of Knowledge to 31 \u003Cjats:styled-content style=\"fixed-case\">M\u003C\u002Fjats:styled-content>arch 2013. Pooled effect sizes with 95% confidence interval (\u003Cjats:styled-content style=\"fixed-case\">CI\u003C\u002Fjats:styled-content>) were calculated using a random effects model. Between‐study heterogeneity was assessed using the \u003Cjats:styled-content style=\"fixed-case\">Q\u003C\u002Fjats:styled-content> test and \u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">I\u003C\u002Fjats:styled-content>\u003C\u002Fjats:italic>\u003Cjats:sup>2\u003C\u002Fjats:sup> statistic.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>In all, 11 articles including 392 \u003Cjats:styled-content style=\"fixed-case\">IBS\u003C\u002Fjats:styled-content> patients and 263 controls met the inclusion criteria of the analysis. \u003Cjats:styled-content style=\"fixed-case\">IBS\u003C\u002Fjats:styled-content> patients had lower \u003Cjats:styled-content style=\"fixed-case\">HF\u003C\u002Fjats:styled-content> band power (\u003Cjats:styled-content style=\"fixed-case\">H\u003C\u002Fjats:styled-content>edges's g = −0.38, 95% \u003Cjats:styled-content style=\"fixed-case\">CI\u003C\u002Fjats:styled-content> −0.68 to −0.09) than the controls (\u003Cjats:italic>\u003Cjats:styled-content style=\"fixed-case\">I\u003C\u002Fjats:styled-content>\u003C\u002Fjats:italic>\u003Cjats:sup>2\u003C\u002Fjats:sup> = 63.6%, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.003). Moreover, \u003Cjats:styled-content style=\"fixed-case\">IBS\u003C\u002Fjats:styled-content> patients showed a higher \u003Cjats:styled-content style=\"fixed-case\">LF\u003C\u002Fjats:styled-content> : \u003Cjats:styled-content style=\"fixed-case\">HF\u003C\u002Fjats:styled-content> (\u003Cjats:styled-content style=\"fixed-case\">H\u003C\u002Fjats:styled-content>edges's g = 0.43, 95% \u003Cjats:styled-content style=\"fixed-case\">CI\u003C\u002Fjats:styled-content> 0.13–0.74), with no significant heterogeneity. A subgroup analysis of the \u003Cjats:styled-content style=\"fixed-case\">HF\u003C\u002Fjats:styled-content> index according to the recording time yielded different results for the \u003Cjats:styled-content style=\"fixed-case\">IBS\u003C\u002Fjats:styled-content> patients and controls. Additionally, constipation‐predominant \u003Cjats:styled-content style=\"fixed-case\">IBS\u003C\u002Fjats:styled-content> (\u003Cjats:styled-content style=\"fixed-case\">IBS\u003C\u002Fjats:styled-content>‐\u003Cjats:styled-content style=\"fixed-case\">C\u003C\u002Fjats:styled-content>) patients had decreased \u003Cjats:styled-content style=\"fixed-case\">HF\u003C\u002Fjats:styled-content> band power, whereas no significant difference was found in \u003Cjats:styled-content style=\"fixed-case\">LF\u003C\u002Fjats:styled-content> : \u003Cjats:styled-content style=\"fixed-case\">HF\u003C\u002Fjats:styled-content>.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>Impaired parasympathetic functioning and abnormal sympathovagal balance may be involved in the pathogenesis of \u003Cjats:styled-content style=\"fixed-case\">IBS\u003C\u002Fjats:styled-content>. Vagal dysfunction is more obvious in the \u003Cjats:styled-content style=\"fixed-case\">IBS\u003C\u002Fjats:styled-content>‐\u003Cjats:styled-content style=\"fixed-case\">C\u003C\u002Fjats:styled-content> subgroup.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":2301,"VI":2302},"Autonomic functioning in irritable bowel syndrome measured by heart rate variability: A meta‐analysis","Chức năng tự động trong hội chứng ruột kích thích được đo bằng biến thiên nhịp tim: Một phân tích meta",{"VOID":2304},"23927739",{"VOID":2306},"10.1111\u002F1751-2980.12092",[111],[390],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002F1751-2980.12092",[2311,2330,2345,2360],{"id":2312,"sortIndex":25,"researcher":24,"roles":2313,"affiliations":2314,"properties":2323,"displayName":2327,"givenName":24,"familyName":24},"faea92ab-61fe-4c73-b998-f526c06a48ff",[],[2315],{"id":2316,"sortIndex":25,"affiliation":2317,"properties":24},"d0a6a482-bc12-4a17-b77b-5b05ee08a571",{"id":2316,"createTime":24,"updateTime":24,"relativeEntities":2318,"slug":24,"properties":2319,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2322,"statistic":24},[],{"title":2320},{"EN":2321},"Department of Gastroenterology, Ren ji Hospital, School of Medicine Shanghai Jiaotong University, Shanghai Institute of Digestive Disease Shanghai China",[],{"orcid":2324,"title":2326,"openalex":2328},{"VOID":2325},"https:\u002F\u002Forcid.org\u002F0000-0003-3173-9492",{"EN":2327},"Qing Liu",{"VOID":2329},"A5042845292",{"id":2331,"sortIndex":135,"researcher":24,"roles":2332,"affiliations":2333,"properties":2340,"displayName":2342,"givenName":24,"familyName":24},"d3ec5c8f-369c-4087-befa-4a21c7c737d9",[],[2334],{"id":2316,"sortIndex":25,"affiliation":2335,"properties":24},{"id":2316,"createTime":24,"updateTime":24,"relativeEntities":2336,"slug":24,"properties":2337,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2339,"statistic":24},[],{"title":2338},{"EN":2321},[],{"title":2341,"openalex":2343},{"EN":2342},"Er Man 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Yan",{"VOID":2359},"A5059567041",{"id":2361,"sortIndex":167,"researcher":24,"roles":2362,"affiliations":2363,"properties":2370,"displayName":2374,"givenName":24,"familyName":24},"f3826795-512c-4b1e-83b8-342609ee113e",[],[2364],{"id":2316,"sortIndex":25,"affiliation":2365,"properties":24},{"id":2316,"createTime":24,"updateTime":24,"relativeEntities":2366,"slug":24,"properties":2367,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2369,"statistic":24},[],{"title":2368},{"EN":2321},[],{"orcid":2371,"title":2373,"openalex":2375},{"VOID":2372},"https:\u002F\u002Forcid.org\u002F0000-0001-7672-5014",{"EN":2374},"Sheng‐Liang 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MV, 1993, Power spectral analysis of heart rate variability: a noninvasive signature of cardiac autonomic function, Crit Rev Biomed Eng, 21, 245",{},{"id":24,"text":2474,"url":24,"identifiers":2475},"10.1111\u002Fj.1469-8986.1997.tb02140.x",{"doi":2474},{"id":24,"text":2477,"url":24,"identifiers":2478},"10.1111\u002Fj.1572-0241.2000.02318.x",{"doi":2477},{"id":24,"text":2480,"url":24,"identifiers":2481},"10.1111\u002Fj.1572-0241.2002.07112.x",{"doi":2480},{"id":24,"text":2483,"url":24,"identifiers":2484},"10.1016\u002Fj.ijcard.2004.09.013",{"doi":2483},{"id":24,"text":2486,"url":24,"identifiers":2487},"10.1177\u002F109980040000200203",{"doi":2486},{"id":24,"text":2489,"url":24,"identifiers":2490},"10.1097\u002F00006842-200109000-00014",{"doi":2489},{"id":24,"text":2492,"url":24,"identifiers":2493},"10.1080\u002F00365520600965749",{"doi":2492},{"id":24,"text":2495,"url":24,"identifiers":2496},"10.1111\u002Fj.1572-0241.2001.03526.x",{"doi":2495},{"id":24,"text":2498,"url":24,"identifiers":2499},"10.1007\u002Fs10620-006-9305-z",{"doi":2498},{"id":24,"text":2501,"url":24,"identifiers":2502},"10.1111\u002Fj.1365-2982.2006.00877.x",{"doi":2501},{"id":24,"text":2504,"url":24,"identifiers":2505},"10.1161\u002F01.CIR.93.5.1043",{"doi":2504},{"id":24,"text":2507,"url":24,"identifiers":2508},"10.1016\u002Fj.biopsycho.2009.05.002",{"doi":2507},{"id":24,"text":2510,"url":24,"identifiers":2511},"Hedges LV, 1985, Statistical Methods for Meta‐Analysis",{},{"id":24,"text":2513,"url":24,"identifiers":2514},"10.1016\u002F0197-2456(86)90046-2",{"doi":2513},{"id":24,"text":2516,"url":24,"identifiers":2517},"10.1002\u002Fsim.1186",{"doi":2516},{"id":24,"text":2519,"url":24,"identifiers":2520},"10.1002\u002Fsim.1482",{"doi":2519},{"id":24,"text":2522,"url":24,"identifiers":2523},"10.1136\u002Fbmj.315.7109.629",{"doi":2522},{"id":24,"text":2525,"url":24,"identifiers":2526},"Mazur M, 2007, Dysfunction of the autonomic nervous system activity is responsible for gastric myoelectric disturbances in the irritable bowel syndrome patients, J Physiol Pharmacol, 58, 131",{},{"id":24,"text":2528,"url":24,"identifiers":2529},"10.1023\u002FA:1018871617483",{"doi":2528},{"id":24,"text":2531,"url":24,"identifiers":2532},"10.1023\u002FA:1010671514618",{"doi":2531},{"id":24,"text":2534,"url":24,"identifiers":2535},"10.1016\u002Fj.psyneuen.2009.10.004",{"doi":2534},{"id":24,"text":2537,"url":24,"identifiers":2538},"10.1097\u002FAJP.0b013e31823ae69e",{"doi":2537},{"id":24,"text":2540,"url":24,"identifiers":2541},"10.12659\u002FMSM.883269",{"doi":2540},{"id":24,"text":2543,"url":24,"identifiers":2544},"10.1016\u002Fj.amjcard.2007.03.056",{"doi":2543},{"id":24,"text":2546,"url":24,"identifiers":2547},"10.1540\u002Fjsmr.45.15",{"doi":2546},{"id":24,"text":2549,"url":24,"identifiers":2550},"10.1016\u002FS0140-6736(87)91792-2",{"doi":2549},{"id":24,"text":2552,"url":24,"identifiers":2553},"10.1111\u002Fj.1365-2982.2007.01042.x",{"doi":2552},{"id":24,"text":2555,"url":24,"identifiers":2556},"10.1159\u002F000050682",{"doi":2555},{"id":24,"text":2558,"url":24,"identifiers":2559},"10.1111\u002Fj.1440-1746.2004.03508.x",{"doi":2558},{"id":24,"text":2561,"url":24,"identifiers":2562},"10.1136\u002Fgut.49.5.706",{"doi":2561},{"id":24,"text":2564,"url":24,"identifiers":2565},"10.1007\u002Fs00535-012-0627-7",{"doi":2564},{"id":24,"text":2567,"url":24,"identifiers":2568},"10.1177\u002F0003319706294555",{"doi":2567},{"id":24,"text":2570,"url":24,"identifiers":2571},"10.1016\u002Fj.autneu.2005.06.007",{"doi":2570},{"id":24,"text":2573,"url":24,"identifiers":2574},"10.1016\u002Fj.biopsycho.2005.08.010",{"doi":2573},{"id":2576,"createTime":2577,"updateTime":2578,"relativeEntities":2579,"slug":2580,"properties":2581,"entityType":106,"verifyStatus":107,"verifyTime":2597,"verifyNote":109,"languages":2598,"translateLanguages":2599,"viewCount":25,"primaryUrl":2600,"fullTextUrl":24,"authors":2601,"publicationType":237,"publisherRelationship":2680,"citationCount":2724,"citationInfo":2725,"publishDate":2729,"publishYear":2726,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":2730,"openAccess":24,"references":2731,"isForceReanalyzing":364},"620d2434-2000-4108-94fe-bb56cb3e59c9","2024-09-30T12:28:25.454+00:00","2025-01-05T09:44:59.409+00:00",[],"High-prevalence-of-hepatitis-C-virus-infection-in-the-largest-province-of-Pakistan",{"mag":2582,"keywords":2584,"openalex":2585,"abstract":2587,"title":2590,"pm":2593,"doi":2595},{"VOID":2583},"2076935121",{"VI":701},{"VOID":2586},"W2076935121",{"VI":2588,"EN":2589},"\u003Cjats:p>\u003Cjats:bold>MỤC TIÊU: \u003C\u002Fjats:bold> Để ước tính tỷ lệ và phổ biến nhiễm virus viêm gan C (HCV) trong dân số chung của Pakistan.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>PHƯƠNG PHÁP: \u003C\u002Fjats:bold> Tổng cộng 6817 mẫu máu đã được thu thập ngẫu nhiên từ những người có vẻ ngoài khỏe mạnh ở Punjab, Pakistan từ tháng 3 năm 1999 đến tháng 4 năm 2001 và từ tháng 9 năm 2006 đến tháng 8 năm 2007. Thông tin chi tiết về kinh tế - xã hội của mỗi người tham gia đã được ghi lại. Tất cả các mẫu đều được xét nghiệm để phát hiện kháng thể anti-HCV và tất cả các mẫu seropositive đều được kiểm tra thêm để xác định RNA HCV bằng phản ứng chuỗi polymerase (PCR).\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>KẾT QUẢ: \u003C\u002Fjats:bold> Trong tổng số 6817 mẫu huyết thanh được thử nghiệm, có 998 mẫu (14.63%) dương tính với kháng thể anti-HCV. RNA HCV PCA đã được phát hiện trong 494 mẫu (49.50%) dương tính với anti-HCV. Tỷ lệ kháng thể anti-HCV đáng kể cao hơn ở nam giới (15.09%) so với nữ giới (12.3%) (\u003Cjats:italic>P \u003C 0.009). Sự khác biệt đáng kể cũng được ghi nhận trong tỷ lệ nhiễm HCV giữa các nhóm tuổi khác nhau (\u003Cjats:italic>P \u003C 0.01). Trong phân tích hồi quy logistic đa biến, việc sử dụng ma túy tiêm (OR điều chỉnh 6.6 [95% CI 4.1–9.9]), truyền máu (OR điều chỉnh 5.9 [95% CI 2.9–12.3]), bị kim chích (OR điều chỉnh 2.2 [95% CI 1.6–3.1]), tái sử dụng ống tiêm (OR điều chỉnh 1.7 [95% CI 0.8–3.6]) và trên 35 tuổi (OR điều chỉnh 1.3 [95% CI 0.9–1.9]) là những yếu tố nguy cơ độc lập đối với việc nhiễm HCV.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>KẾT LUẬN: \u003C\u002Fjats:bold> Nghiên cứu cho thấy tỷ lệ seroprevalence cao của kháng thể anti-HCV trong dân số chung và có vẻ khỏe mạnh ở tỉnh Punjab của Pakistan. Tiêm chích ma túy, truyền máu và bị kim chích là những yếu tố có mối liên hệ chặt chẽ nhất với việc nhiễm HCV.\u003C\u002Fjats:p>","\u003Cjats:p>\u003Cjats:bold>OBJECTIVE: \u003C\u002Fjats:bold> To estimate the prevalence and spectrum of hepatitis C virus (HCV) infection in the general population of Pakistan.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>METHODS: \u003C\u002Fjats:bold> A total of 6817 blood samples were collected randomly from apparently healthy people in the Punjab, Pakistan from March 1999 to April 2001 and September 2006 to August 2007. Detailed socioeconomic information for each participant was recorded. All the samples were tested for anti‐HCV antibodies and all seropositive samples were further tested for HCV RNA by polymerase chain reaction (PCR).\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>RESULTS: \u003C\u002Fjats:bold> Of the total 6817 serum samples tested, 998 (14.63%) were positive for anti‐HCV antibodies. HCV RNA PCR was detected in 494 (49.50%) anti‐HCV‐positive samples. The prevalence of anti‐HCV antibodies were significantly higher in males (15.09%) than in females (12.3%) (\u003Cjats:italic>P <\u003C\u002Fjats:italic> 0.009). A significant difference was also noted in the anti‐HCV prevalence rate among different age groups tested (\u003Cjats:italic>P <\u003C\u002Fjats:italic> 0.01). In a multivariate logistic regression analysis, injected drug use (adjusted \u003Cjats:italic>OR\u003C\u002Fjats:italic> 6.6 [95%\u003Cjats:italic>CI\u003C\u002Fjats:italic> 4.1–9.9]), blood transfusion (adjusted \u003Cjats:italic>OR\u003C\u002Fjats:italic> 5.9 [95%\u003Cjats:italic>CI\u003C\u002Fjats:italic> 2.9–12.3]), pricked with a needle (adjusted \u003Cjats:italic>OR\u003C\u002Fjats:italic> 2.2 [95%\u003Cjats:italic>CI\u003C\u002Fjats:italic> 1.6–3.1]), re‐use of syringes (adjusted \u003Cjats:italic>OR\u003C\u002Fjats:italic> 1.7 [95%\u003Cjats:italic>CI\u003C\u002Fjats:italic> 0.8–3.6]) and being over 35 years old (adjusted \u003Cjats:italic>OR\u003C\u002Fjats:italic> 1.3 [95%\u003Cjats:italic>CI\u003C\u002Fjats:italic> 0.9–1.9]) were independent risk factors for HCV infection.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>CONCLUSION: \u003C\u002Fjats:bold> The study showed a high seroprevalence of anti‐HCV antibodies in a general and apparently healthy population of the Punjab province of Pakistan. Drug injection, blood transfusion and needle stuck were the factors most strongly associated with HCV infection.\u003C\u002Fjats:p>",{"EN":2591,"VI":2592},"High prevalence of hepatitis C virus infection in the largest province of Pakistan","Tỷ lệ nhiễm virus viêm gan C cao ở tỉnh lớn nhất của 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