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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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lipids and glycemic dysregulation are the known characteristics of β- thalassemia major (β-TM). Here, we evaluated the association of these disorders with insulin resistance (IR), oxidative stress and serum ferritin values in patients with β-TM. This case-control study was performed in thalassemia unite of Darab Hospital (Darab, Fars province, Iran) from December 2016 to December 2017. Forty-eight patients with β-TM and 33 healthy individuals were enrolled. Serum fasting blood sugar (FBS), insulin, total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), ischemia modified albumin (IMA), and ferritin were measured. The values of HOMA-IR, LDL: TG ratio, atherogenic index (AI), atherogenic index of plasma (AIP), and coronary risk index (CRI) were calculated. The level of serum ferritin, IMA, FBS, TG, AIP, LDL: TG ratio, and the prevalence of IR (HOMA-IR \u003C 3.8) were significantly higher while TC, LDL-C, HDL-C, and AI were significantly lower in the patients compared to the control group. In patient with β-TM, serum ferritin revealed to have a positive association with serum insulin, HOMA-IR, AI, and CRI levels while serum IMA showed positive association with TG and AIP and inverse association with hypocholesterolemia. HOMA-IR had positive correlation with HDL levels. Oxidative stress and iron overload are predictors of serum glycemic and lipid dysregulation, suggesting possible beneficial effect of antioxidants and efficient iron chelating therapy in reducing the risk of metabolic disorders in β- thalassemia.",{"EN":966},"The effects of iron overload, insulin resistance and oxidative stress on metabolic disorders in patients with β- thalassemia major",{"VOID":968},"Musallam KM, Cappellini MD, Wood JC, Taher AT. Iron overload in non-transfusion-dependent thalassemia: a clinical perspective. Blood reviews. 2012;26:16-S9.\nKoohi F, Kazemi T, Miri-Moghaddam E. Cardiac complications and iron overload in beta thalassemia major patients—a systematic review and meta-analysis. Annals of hematology. 2019;98(6):1323–31.\nMotta I, Mancarella M, Marcon A, Vicenzi M, Cappellini MD. Management of age-associated medical complications in patients with β-thalassemia. Expert review of hematology. 2020;13(1):85–94.\nNoetzli LJ, Mittelman SD, Watanabe RM, Coates TD, Wood JC. Pancreatic iron and glucose dysregulation in thalassemia major. Am J Hematol. 2012;87(2):155–60\nWadhera RK, Steen DL, Khan I, Giugliano RP, Foody JM. A review of low-density lipoprotein cholesterol, treatment strategies, and its impact on cardiovascular disease morbidity and mortality. J Clin Lipidol. 2016;10(3):472–89.\nBoudrahem-Addour N, Izem-Meziane M, Bouguerra K, Nadjem N, Zidani N, Belhani M, et al. Oxidative status and plasma lipid profile in β-thalassemia patients. Hemoglobin. 2015;39(1):36–41.\nRagab SM, Safan MA, Obeid OM, Sherief AS. Lipoprotein-associated phospholipase A2 (Lp-PLA2) and tumor necrosis factor-alpha (TNF-α) and their relation to premature atherosclerosis in β-thalassemia children. Hematology. 2015;20(4):228–38.\nSherief LM, Dawood O, Ali A, Sherbiny HS, Kamal NM, Elshanshory M, et al. Premature atherosclerosis in children with beta-thalassemia major: New diagnostic marker. BMC Pediatr. 2017;17(1):69.\nLuo Y, Bajoria R, Lai Y, Pan H, Li Q, Zhang Z, et al. Prevalence of abnormal glucose homeostasis in Chinese patients with non-transfusion-dependent thalassemia. Diabetes metabolic syndrome obesity: targets therapy. 2019;12:457.\nHezaveh ZS, Azarkeivan A, Janani L, Shidfar F. Effect of quercetin on oxidative stress and liver function in beta-thalassemia major patients receiving desferrioxamine: A double-blind randomized clinical trial. J Res Med Sci. 2019;24.\nTselepis AD, Hahalis G, Tellis CC, Papavasiliou EC, Mylona PT, Kourakli A et al. Plasma levels of lipoprotein-associated phospholipase A(2) are increased in patients with beta-thalassemia. J Lipid Res. 2010;51(11):3331–41\nAl IO, Ayçiçek A, Ersoy G, Bayram C, Neselioglu S, Erel Ö. Thiol Disulfide Homeostasis and Ischemia-modified Albumin Level in Children With Beta-Thalassemia. J Pediatr Hematol Oncol. 2019;41(7):e463-e6.\nAwadallah SM, Atoum MF, Nimer NA, Saleh SA. Ischemia modified albumin: An oxidative stress marker in β-thalassemia major. Clin Chim Acta. 2012;413(9–10):907–10.\nAdly AAM, ElSherif NHK, Ismail EAR, Ibrahim YA, Niazi G, Elmetwally SH. Ischemia-modified albumin as a marker of vascular dysfunction and subclinical atherosclerosis in β-thalassemia major. Redox Rep. 2017;22(6):430–8.\nElbeblawy N, Abdelmaksoud A, Elguindy W, Elshinawy D, Abdelwahed G. Ischemia modified albumin in Egyptian patients with β-thalassemia major: relation to cardiac complications. QJM. 2018;111(suppl_1):hcy200\nOrdovas JM. Gene-diet interactions and cardiovascular diseases: Saturated and monounsaturated fat. Principles of nutrigenetics and nutrigenomics: Elsevier, Amsterdam; 2020. p. 211 – 22.\nBuckner JD, Zvolensky MJ, Businelle MS, Gallagher MW. Direct and indirect effects of false safety behaviors on cannabis use and related problems. Am J Addict. 2018;27(1):29–34\nCrary SE, Buchanan GR. Vascular complications after splenectomy for hematologic disorders. Blood. 2009;114(14):2861–8\nAsadi P, Vessal M, Khorsand M, Takhshid MA. Erythrocyte glucose-6-phosphate dehydrogenase activity and risk of gestational diabetes. J Diabetes Metab Disord. 2019;18(2):533–41\nKeshavarzi F, Rastegar M, Vessal M, Dehbidi GR, Khorsand M, Ganjkarimi AH et al. Serum ischemia modified albumin is a possible new marker of oxidative stress in phenylketonuria. Metab Brain Dis. 2018;33(3):675–80\nTaher AT, Saliba AN. Iron overload in thalassemia: different organs at different rates. Hematology 2014, the American Society of Hematology. Education Program Book. 2017;2017(1):265–71\nCoverdale JP, Katundu KG, Sobczak AI, Arya S, Blindauer CA, Stewart AJ. Ischemia-modified albumin: Crosstalk between fatty acid and cobalt binding. Prostaglandins Leukot Essent Fatty Acids. 2018;135:147–57.\nTakhshid M, Kojuri J, Tabei S, Tavasouli A, Heidary S, Tabandeh M. Early diagnosis of acute coronary syndrome with sensitive troponin I and ischemia modified albumin. 2010.\nEl-Farrash RA, Ismail EA, Nada AS, Hassan KY. Ischemia modified albumin levels in infants of diabetic mother: Relation to maternal glycemic control. Egypt J Pediatr. 2017;394(5961):1–6\nGhergherehchi R, Habibzadeh A. Insulin resistance and β cell function in patients with β-thalassemia major. Hemoglobin. 2015;39(1):69–73.\nSoliman A, Yassin M, Al Yafei F, Al-Naimi L, Almarri N, Sabt A et al. Longitudinal study on liver functions in patients with thalassemia major before and after deferasirox (DFX) therapy. Mediterr J Hematol Infect Dis. 2014;6(1):e2014025.\nAmin A, Jalali S, Amin R, Aale-yasin S, Jamalian N, Karimi M. Evaluation of the serum levels of immunoglobulin and complement factors in b-thalassemia major patients in Southern Iran. Iran J Immunol. 2005;2(4):220–5\nShanab A, El-Desouky M, Kholoussi N, El-Kamah G, Fahmi A. Evaluation of neopterin as a prognostic factor in patients with beta-thalassemia, in comparison with cytokines and immunoglobulins. Arch Hell Med\u002FArheia Ellenikes Iatrikes. 2015;32(1).\nAyyash H, Sirdah M. Hematological and biochemical evaluation of β-thalassemia major (βTM) patients in Gaza Strip: A cross-sectional study. Int J Health Sci. 2018;12(6):18\nBalci YI, Ünal S, Gümrük F. Serum lipids in Turkish patients with [Beta]-Thalassemia Major and [Beta]-Thalassemia Minor\u002FTürk [Beta]-Talasemi Majör ve [Beta]-Talasemi Minör Hastalarinin serum lipidleri. Turk J Haematol. 2016;33(1):42\nIbrahim HA, Zakaria SS, Elbatch MM, Ramadan M. New insight on premature atherosclerosis in Egyptian children with β-thalassemia major. 2018.\nTselepis AD, Hahalis G, Tellis CC, Papavasiliou EC, Mylona PT, Kourakli A et al. Plasma levels of lipoprotein-associated phospholipase A2 are increased in patients with β-thalassemia. J Lipid Res. 2010;51(11):3331–41\nArıca V, Arıca S, Özer C, Çevik M. Serum lipid values in children with beta thalassemia major. Pediatr Ther. 2012;2(5):1–3\nHaghpanah S, Davani M, Samadi B, Ashrafi A, Karimi M. Serum lipid profiles in patients with beta-thalassemia major and intermedia in southern Iran. J Res Med Sci. 2010;15(3):150\nKim YE, Kim DH, Roh YK, Ju SY, Yoon YJ, Nam GE et al. Relationship between Serum Ferritin Levels and Dyslipidemia in Korean Adolescents. PLoS One. 2016;11(4):e0153167\nCalandra S, Bertolini S, Pes GM, Deiana L, Tarugi P, Pisciotta L et al, editors Β-thalassemia is a modifying factor of the clinical expression of familial hypercholesterolemia. Seminars in vascular medicine; 2004: Copyright© 2004 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New &#8230.\nTangvarasittichai S, Pimanprom A, Choowet A, Tangvarasittichai O. Association of iron overload and oxidative stress with insulin resistance in transfusion-dependent beta-thalassemia major and beta-thalassemia\u002FHbE patients. Clin Lab. 2013;59(7–8):861–8.\nSonuga OO, Abbiyesuku FM, Adedapo KS, Sonuga AA. Insulin resistance index and proatherogenic lipid indices in the offspring of people with diabetes. Int J Diabetes Metab. 2019;25(1–2):11–8\nEl-Samahy MH, Tantawy AA, Adly AA, Abdelmaksoud AA, Ismail EA, Salah NY. Evaluation of continuous glucose monitoring system for detection of alterations in glucose homeostasis in pediatric patients with β‐thalassemia major. Pediatr Diabetes. 2019;20(1):65–72.",{"VOID":970},"10.1007\u002Fs40200-020-00560-x","PUBLICATION","Auto Verify","https:\u002F\u002Fidp.springer.com\u002Fauthorize?response_type=cookie&client_id=springerlink&redirect_uri=https%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs40200-020-00560-x",[975,991,1015],{"id":976,"sortIndex":32,"researcher":28,"roles":977,"affiliations":979,"properties":988,"displayName":990,"givenName":28,"familyName":28},"2bb88108-3d5d-4021-a3d2-8a0e54e030ba",[978],"AUTHOR",[980],{"id":981,"sortIndex":32,"affiliation":982,"properties":28},"9f9e1273-a686-4bf9-8589-1cd881c445fb",{"id":981,"createTime":28,"updateTime":28,"relativeEntities":983,"slug":28,"properties":984,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":987,"statistic":28},[],{"title":985},{"VI":986},"School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran",[],{"title":989},{"VI":990},"Soheila 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Dopamine-2 receptor agonists, Bromocriptine and Cabergoline, were originally introduced for prolactinomas, pituitary tumors, and parkinson’s disease but have glucose-lowering effects. This paper systematically reviewed the significance of their effects on lowering blood glucose level and conducted a comprehensive systematic search to identify relevant clinical trials of dopamine 2 agonists on glycated hemoglobin (HbA1c) and fasting blood sugar (FBS). We conducted a systematic review search in the databases (PubMed, Google Scholar, Cochrane Library, Registers, and Citations) until November 30, 2022, using the PRISMA 2020 statement. The Oxford quality score (Jadad score) was used to assess the study’s quality. The present study protocol was registered on the PROSPERO database with ID: CRD42023389582. The study included studies with full abstracts, predefined doses, clear interventions, and blood glucose measurements. Data were synthesized from 23 clinical studies that recruited 6125 study subjects. The pooled effect analysis of the clinical trials revealed that dopamine 2 agonists improved HbA1c [SMD = -1.26; 95% CI (-1.60, -0.93), P \u003C .00001], and FBS [SMD = -1.84; 95% CI (-2.61, -1.07), P \u003C .00001]. Each drug’s pooled effect analysis indicates bromocriptine significantly improved HbA1c [SMD = -1.25; 95% CI (-1.64, -0.87), P \u003C .00001] and FBS [SMD = -1.90; 95% CI (-2.79, -1.01), P \u003C .00001] and similarly, cabergoline significantly improved HbA1c [SMD = -1.29; 95% CI (-1.96, -0.62), P \u003C .00001] and FBS [SMD = -1.62; 95% CI (-2.82, -0.41), P \u003C .00001]. The pooled and individual analyses demonstrated that dopamine 2 agonists have a significant ability to lower blood glucose levels in clinical studies. This study shows that dopamine 2 agonists significantly lowered FBS and HbA1c levels without causing severe negative effects. Even though the results are promising, additional research is necessary to establish the appropriate antihyperglycemic dosage, frequency of daily use, side effects, and potential product interactions when employing dopamine 2 receptor agonists for their antihyperglycemic effect.",{"EN":1101},"Dopamine 2 agonists for the management of type 2 diabetes: a systematic review and meta-analysis",{"VOID":1103},"Care D, Suppl SS. Introduction: Standards of medical care in diabetes — 2022. Diabetes Care. 2022;45:2021–2.\nIatcu CO, Steen A, Covasa M. Gut microbiota and complications of type-2 diabetes. Nutrients. 2022. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fnu14010166.\nMolinaro R, Dauscher C. Complications resulting from uncontrolled diabetes. MLO Med Lab Obs. 2017;49:2022.\nIDF Diabetes Atlas. International Diabetes Federation. Diabetes Res Clin Pract. 2021. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.diabres.2013.10.013.\nLucier J, Weinstock RS. Diabetes Mellitus Type 1. StatPearls. StatPearls Publ; 2022.\nIngle PV, Yin SB, Ying BJ, Leong BK, Xin TZ, Hwa LT, Mun LT. Current trends in pharmacological treatment of type II diabetes mellitus. Int J Pharmacol Res Rev. 2018;7:1–15.\nKumar S, Mittal A, Babu D, Mittal A. Herbal medicines for diabetes management and its secondary complications. Curr Diabetes Rev. 2021;17:437–56.\nPadhi S, Nayak AK, Behera A. Type II diabetes mellitus: a review on recent drug based therapeutics. Biomed Pharmacother. 2020;131:1–23.\nLamos EM, Levitt DL, Munir KM. A review of dopamine agonist therapy in type 2 diabetes and effects on cardio-metabolic parameters. Prim Care Diabetes. 2016;10:60–5.\nMahajan R. Bromocriptine mesylate: FDA-approved novel treatment for type-2 diabetes. Indian J Pharmacol. 2009;41:197–8.\nLopez Vicchi F, Luque GM, Brie B, Nogueira JP, Garcia Tornadu I, Becu-Villalobos D. Dopaminergic drugs in type 2 diabetes and glucose homeostasis. Pharmacol Res. 2016;109:74–80.\nDeFronzo RA. Bromocriptine: a sympatholytic, D2-dopamine agonist for the treatment of type 2 diabetes. Diabetes Care. 2011;34:789–94.\nLuo S, Meier AH, Cincotta AH. Bromocriptine reduces obesity, glucose intolerance and extracellular monoamine metabolite levels in the ventromedial hypothalamus of syrian hamsters. Neuroendocrinology. 1998;68:1–10.\nByberg S, Futtrup J, Andreassen M, Krogh J. Metabolic effects of dopamine agonists in patients with prolactinomas: a systematic review and meta-analysis. Endocr Connect. 2019;8:1395–404.\nSchwartz SS, Zangeneh F. Evidence-based practice use of quick-release bromocriptine across the natural history of type 2 diabetes mellitus. Postgrad Med. 2016;128:828–38.\nLiang W, Gao L, Li N, et al. Efficacy and safety of Bromocriptine-QR in type 2 diabetes: a systematic review and Meta-analysis. Horm Metab Res. 2015;47:805–12.\nOoi CP, Lye MS. Bromocriptine for type 2 diabetes mellitus. Cochrane Database Syst Rev. 2018. https:\u002F\u002Fdoi.org\u002F10.1002\u002F14651858.CD010319.pub2.\nIgata M, Yagi Y, Hanatani S, Sakaguchi M, Ishii N, Yoshinaga K, Kawashima J, Motoshima H, Araki E. Rapid and dramatic glucose-lowering effect of bromocriptine in an inadequately controlled type 2 diabetes patient with prolactinoma. J Diabetes Investig. 2021;12:668–71.\nChamarthi B, Gaziano JM, Blonde L, Vinik A, Scranton RE, Ezrokhi M, Rutty D, Cincotta AH. Timed bromocriptine-QR therapy reduces progression of cardiovascular disease and dysglycemia in subjects with well-controlled type 2 diabetes mellitus. J Diabetes Res. 2015. https:\u002F\u002Fdoi.org\u002F10.1155\u002F2015\u002F157698.\nAndersen IB, Andreassen M, Krogh J. The effect of dopamine agonists on metabolic variables in adults with type 2 diabetes: a systematic review with meta analysis and trial sequential analysis of randomized clinical trials. Diabetes Obes Metab. 2021;23:58–67.\nMuka T, Glisic M, Milic J, Verhoog S, Bohlius J, Bramer W, Chowdhury R, Franco OH. A 24-step guide on how to design, conduct, and successfully publish a systematic review and meta-analysis in medical research. Eur J Epidemiol. 2020;35:49–60.\nSiddaway AP, Wood AM, Hedges LV. How to do a systematic review: a best practice guide for conducting and reporting narrative reviews, meta-analyses, and meta-syntheses. Annu Rev Psychol. 2018;70:747–70.\nSchmidt L, Shokraneh F, Steinhausen K, Adams CE. Introducing RAPTOR: RevMan parsing tool for reviewers. Syst Rev. 2019;8:6–9.\nMigliavaca CB, Stein C, Colpani V, Barker TH, Ziegelmann PK, Munn Z, Falavigna M. Meta-analysis of prevalence: I(2) statistic and how to deal with heterogeneity. Res Synth Methods. 2022;13:363–7.\nAisbett J, Drinkwater EJ, Quarrie KL, Woodcock S. Applying generalized funnel plots to help design statistical analyses. Stat Pap. 2022. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00362-022-01322-y.\nHiggins J, Green S, Sally E, Cochrane Collaboration. Chap. 8: Assessing risk of bias in included studies Cochrane handbook for systematic reviews of interventions; 2017.\nCochrane Collaboration. Review Manager Web (RevMan Web); 2020.\nHaddaway NR, Page MJ, Pritchard CC, McGuinness LA. PRISMA2020: an R package and Shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and open synthesis. Campbell Syst Rev. 2022;18:1–12.\nPage MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021. https:\u002F\u002Fdoi.org\u002F10.1136\u002Fbmj.n71.\nAliAsgarzadeh A, Karimiavval S, Houshyar J, Gojazadeh M, Hadi A. Evaluating the effect of cabergoline on glycaemic control of patients with type 2 diabetes mellitus: a randomised controlled Trial. J Clin Diagnostic Res. 2020:1–4.\nBahar A, Kashi Z, Daneshpour E, Akha O, Ala S. Effects of cabergoline on blood glucose levels in type 2 diabetic patients. Med (Baltim). 2016;95:e4818.\nBarnett H, Chapman C, Gailer K, Hayter CJ. Effect of bromocriptine on maturity onset diabetes. Postgrad Med J. 1980;56:11–4.\nChamarthi B, Ezrokhi M, Rutty D, Cincotta AH. Impact of bromocriptine-QR therapy on cardiovascular outcomes in type 2 diabetes mellitus subjects on metformin. Postgrad Med. 2016;128:761–9.\nGhosh A, Sengupta N, Sahana P, Giri D, Sengupta P, Das N. Efficacy and safety of add on therapy of bromocriptine with metformin in indian patients with type 2 diabetes mellitus: a randomized open labeled phase IV clinical trial. Indian J Pharmacol. 2014;46:24–8.\nKok P, Roelfsema F, Frölich M, Van Pelt J, Stokkel MPM, Meinders AE, Pijl H. Activation of dopamine D2 receptors simultaneously ameliorates various metabolic features of obese women. Am J Physiol - Endocrinol Metab. 2006;291:1038–43.\nKrysiak R, Okopien B. Different effects of cabergoline and bromocriptine on metabolic and cardiovascular risk factors in patients with elevated prolactin levels. Basic Clin Pharmacol Toxicol. 2015;116:251–6.\nMeier AH, Cincotta AH, Lovell WC. Timed bromocriptine administration reduces body fat stores in obese subjects and hyperglycemia in type II diabetics. Experientia. 1992;48:248–53.\nMejía-Rodríguez O, Herrera-Abarca JE, Ceballos-Reyes G, et al. Cardiovascular and renal effects of bromocriptine in diabetic patients with stage 4 chronic kidney disease. Biomed Res Int. 2013. https:\u002F\u002Fdoi.org\u002F10.1155\u002F2013\u002F104059.\nPijl H, Ohashi S, Matsuda M, et al. Bromocriptine: a novel approach to the treatment of type 2 diabetes. Diabetes Care. 2000;23:1154–61.\nTaghavi SM, Fatemi SS, Rokni H. Cabergoline effect on blood sugar in type 2 diabetic patients with oral agent failure. Med J Malaysia. 2012;67:390–2.\nAminorroaya A, Janghorbani M, Ramezani M, Haghighi S, Amini M. Does bromocriptine improve glycemic control of obese type-2 diabetics? Horm Res. 2004;62:55–9.\nAssad HC, Mosah HA, Hashim HM, Khazaal FA. Effect of cabergoline added to metformin on glycemic control, insulin resistance and beta cell function in obese type 2 diabetic patients. Type Double Blind Peer Rev. Int Res J Publ Glob J Inc. 2014;14.\nChamarthi B, Cincotta AH. Effect of bromocriptine-QR therapy on glycemic control in subjects with type 2 diabetes mellitus whose dysglycemia is inadequately controlled on insulin. Postgrad Med. 2017;129:446–55.\nCincotta AH, Meier AH. Bromocriptine (Ergoset) reduces body weight and improves glucose tolerance in obese subjects. Diabetes Care. 1996;19:667–70.\nGaziano JM, Cincotta AH, O’Connor CM, Ezrokhi M, Rutty D, Ma ZJ, Scranton RE. Randomized clinical trial of quick-release bromocriptine among patients with type 2 diabetes on overall safety and cardiovascular outcomes. Diabetes Care. 2010;33:1503–8.\nKamath V, Jones CN, Yip JC, Varasteh BB, Cincotta AH, Reaven GM, Chen YD. Effects of a quick-release form of bromocriptine (Ergoset) on fasting and postprandial plasma glucose, insulin, lipid, and lipoprotein concentrations in obese nondiabetic hyperinsulinemic women. Diabetes Care. 1997;20:1697–701.\nKhalilzade S, Aminorroaya A, Hovsepain S, Amini M. Efficacy of bromocriptine on glycemic and metabolic control of prediabetic patients. Adv Biomed Res. 2015;4:253.\nMorcos JA, Ebeid AM, Khodeir SA, Elazab GA. Co-administration of Cabergoline and Gliclazide improve glycemic parameters and lipid Profile in T2DM. J Diabetes Metab. 2017. https:\u002F\u002Fdoi.org\u002F10.4172\u002F2155-6156.1000759.\nRamteke K, Ramanand S, Ramanand J, Jain S, Raparti G, Patwardhan M, Murthy M, Ghanghas R. Evaluation of the efficacy and safety of bromocriptine QR in type 2 diabetes. Indian J Endocrinol Metab. 2011;15:33.\nRoe ED, Chamarthi B, Raskin P. Impact of bromocriptine-QR therapy on glycemic control and daily insulin requirement in type 2 diabetes mellitus subjects whose dysglycemia is poorly controlled on high-dose insulin: a pilot study. J Diabetes Res. 2015. https:\u002F\u002Fdoi.org\u002F10.1155\u002F2015\u002F834903.\nTell SS, Schafer M, Vigers T, Baumgartner AD, Lyon E, Gross S, Polsky S, Snell-Bergeon JK, Schauer IE, Nadeau KJ. Bromocriptine quick-release as adjunct therapy in youth and adults with type 1 diabetes: a randomized, placebo-controlled crossover study. Diabetes Obes Metab. 2022;24:2148–58.\nVinik AI, Cincotta AH, Scranton RE, Bohannon N, Ezrokhi M, Gaziano JM. Effect of Bromocriptine-QR on glycemic control in subjects with uncontrolled hyperglycemia on one or two oral anti-diabetes agents. Endocr Pract. 2012;18:931–43.\ndu Sert NP, Hurst V, Ahluwalia A, et al. The arrive guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol. 2020;18:1–12.\nKilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: the arrive guidelines for reporting animal research. PLoS Biol. 2010;8:6–10.\nWinzap P, Davies A, Klingenberg R, et al. Diabetes and baseline glucose are associated with inflammation, left ventricular function and short- and long-term outcome in acute coronary syndromes: role of the novel biomarker Cyr 61. Cardiovasc Diabetol. 2019;18:1–10.\nBerard LD, Siemens R, Woo V. Monitoring glycemic control. Can J Diabetes. 2018;42:47-S53.\nDos Santos Nunes V, El Dib R, Boguszewski CL, Nogueira CR. Cabergoline versus bromocriptine in the treatment of hyperprolactinemia: a systematic review of randomized controlled trials and meta-analysis. Pituitary. 2011;14:259–65.\nMikhail N. Quick-release bromocriptine for treatment of type 2 diabetes. Curr Drug Deliv. 2011;8:511–6.",{"VOID":1105},"10.1007\u002Fs40200-023-01230-4","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs40200-023-01230-4",[1108,1123],{"id":1109,"sortIndex":32,"researcher":28,"roles":1110,"affiliations":1111,"properties":1120,"displayName":1122,"givenName":28,"familyName":28},"6d3c4c95-02aa-467a-975f-63295839cb8b",[978],[1112],{"id":1113,"sortIndex":32,"affiliation":1114,"properties":28},"42c49ed0-7c4a-4a57-8329-41ec5441ec32",{"id":1113,"createTime":28,"updateTime":28,"relativeEntities":1115,"slug":28,"properties":1116,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1119,"statistic":28},[],{"title":1117},{"VI":1118},"Department of Pharmacology, School of Medicine, College of Medicine and Health Sciences, Dire Dawa University, Dire Dawa, Ethiopia",[],{"title":1121},{"VI":1122},"Beyene Dereje",{"id":1124,"sortIndex":40,"researcher":28,"roles":1125,"affiliations":1126,"properties":1135,"displayName":1137,"givenName":28,"familyName":28},"d6ac803e-6447-4bbf-8e53-9dca1146d214",[978],[1127],{"id":1128,"sortIndex":32,"affiliation":1129,"properties":28},"5696e26c-a205-4739-b0af-73c7951b4145",{"id":1128,"createTime":28,"updateTime":28,"relativeEntities":1130,"slug":28,"properties":1131,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1134,"statistic":28},[],{"title":1132},{"VI":1133},"Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia",[],{"title":1136},{"VI":1137},"Aschalew Nardos",{"url":1106,"publisher":1139,"properties":1184},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1140,"slug":872,"properties":1141,"entityType":25,"verifyStatus":878,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1144,"manageAffiliations":1153,"indexDatabases":1164,"url":932,"thumbnailPath":28,"statistic":1179,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1142,"title":1143},{"VOID":875},{"EN":877},[1145,1149],{"id":881,"createTime":28,"updateTime":28,"relativeEntities":1146,"label":1147,"description":1148,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":884},{},{"id":887,"createTime":28,"updateTime":28,"relativeEntities":1150,"label":1151,"description":1152,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},[1154,1159],{"id":894,"createTime":28,"updateTime":28,"relativeEntities":1155,"slug":28,"properties":1156,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1158,"statistic":28},[],{"title":1157},{"EN":898},[],{"id":901,"createTime":28,"updateTime":28,"relativeEntities":1160,"slug":28,"properties":1161,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1163,"statistic":28},[],{"title":1162},{"EN":905},[907],[1165,1172],{"id":910,"indexDatabase":1166,"url":916,"indexYears":28,"academicFieldIds":1171,"indexDatabaseRanking":28},{"id":803,"createTime":28,"updateTime":28,"relativeEntities":1167,"label":1168,"description":1169,"key":810,"publicationTags":1170,"standard":28},[],{"EN":806,"VI":806},{"EN":808,"VI":809},[812,813],[918],{"id":920,"indexDatabase":1173,"url":926,"indexYears":927,"academicFieldIds":1178,"indexDatabaseRanking":931},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":1174,"label":1175,"description":1176,"key":781,"publicationTags":1177,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[929,930],{"impactFactor":32,"impactFactorByYear":1180,"i10Index":162,"i10IndexLast5Year":135,"totalPublication":936,"totalPublicationByYear":1181,"totalCitation":941,"totalCitationByYear":1182,"totalCitationPerPublication":344,"totalCitationPerPublicationByYear":1183,"hindexLast5Year":135,"hindex":135},{"2017":106,"2018":121,"2019":423,"2020":319,"2021":935,"2022":935,"2023":117},{"2012":51,"2013":138,"2014":208,"2015":689,"2016":132,"2017":142,"2018":148,"2019":560,"2020":938,"2021":939,"2022":938,"2023":940,"2024":131},{"2015":161,"2016":132,"2017":938,"2018":196,"2019":943,"2020":944,"2021":566,"2022":516},{"2015":585,"2016":40,"2017":946,"2018":947,"2019":948,"2020":949,"2021":950,"2022":951},{"pages":1185,"volume":1187},{"VOID":1186},"931-943",{"VOID":1188},"22","2023-05-12",2023,[931,812],{"id":1193,"createTime":1194,"updateTime":1195,"relativeEntities":1196,"slug":1197,"properties":1198,"entityType":971,"verifyStatus":26,"verifyTime":1195,"verifyNote":972,"languages":28,"translateLanguages":28,"viewCount":123,"primaryUrl":1207,"fullTextUrl":28,"authors":1208,"publicationType":1035,"publisherRelationship":1287,"citationCount":28,"citationInfo":28,"publishDate":1338,"publishYear":1339,"citationAnalyzeStatus":878,"lastCitationAnalyze":28,"indexDatabases":1340,"openAccess":28,"references":28,"isForceReanalyzing":1090},"011cfaaa-facc-4ee0-9ff8-88805c020626","2023-12-05T16:24:00.960+00:00","2025-01-22T09:17:26.592+00:00",[],"PPAR%C9%A32-aldose-reductase-and-TCF7L2-gene-polymorphisms-relation-to-diabetes-mellitus",{"abstract":1199,"title":1201,"references":1203,"doi":1205},{"EN":1200},"Diabetes mellitus (DM) is a growing global health concern. Genetic factors play a pivotal role in the development of diabetes. Therefore, the present work aimed to study the relation between peroxisome proliferator-activate receptors (PPARɣ2) (rs3856806), aldose reductase (AR) (rs759853), transcription factor 7 like 2 (TCF7L2) (rs7903146) gene polymorphism with diabetes in the Egyptian population. The study included 260 diabetics and 120 healthy subjects. Genotyping was done using polymerase chain reaction-restriction fragment length polymorphism. Regression analysis revealed that PPARɣ2 TT, TCF7L2 TT were suggested to be independent risk predictors for T1DM and TCF7L2 TC, CC genotype were suggested to be independent protective factors against T1DM development. On the other hand, PPARɣ2 TT, AR TT genotypes were suggested to be independent risk predictors for T2DM susceptibility, and PPARɣ2 CT genotypes were suggested to be independent protective factors against T2DM development. The present study revealed that PPARγ2 (rs3856806), TCF7L2 (rs7903146) and AR (rs759853) gene polymorphism may play an important role in the susceptibility of diabetes. Therefore, these polymorphisms may have a prognostic value for diabetes in the Egyptian population. Further work is required to confirm the role of these polymorphisms in diabetes.",{"EN":1202},"PPARɣ2, aldose reductase, and TCF7L2 gene polymorphisms: relation to diabetes mellitus",{"VOID":1204},"Şanlier N, Gencer F. Role of spices in the treatment of diabetes mellitus: A minireview. Trends Food Sci Technol 2020; 99: 441–449. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.tifs.2020.03.018\nOmar GA, Alib OSM, Ismaila AA, Mohamed GS. Transcription factor 7-like 2 rs7903146 polymorphism and therapeutic response to sulfonylureas in patients with type 2 diabetes. J Med Sci Res. 2018;1(3):168–72. https:\u002F\u002Fdoi.org\u002F10.4103\u002FJMISR.JMISR_43_18.\nTan SY, Wong JLM, Sim YJ, Wong SS, Elhassan SAM, Tan SH, Lim GPL, Tay NWR, Annan NC, Bhattamisra SK, Candasamy M. Type 1 and 2 diabetes mellitus: a review on current treatment approach and gene therapy as potential intervention. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2019;13:364–72. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.dsx.2018.10.008.\nKaralliedde J, Gnudi L. Diabetes mellitus, a complex and heterogeneous disease, and the role of insulin resistance as a determinant of diabetic kidney disease. Nephrology Dialysis Transplantation. 2016;31(2, 1):206–13. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fndt\u002Fgfu405.\nHussain T, Tan B, Murtaza G, Liu G, Rahu N, Kalhoro MS, Kalhoro DH, Adebowale TO, Mazhar MU, Rehman ZU, Martínez Y, Khan SA, Yin Y. Flavonoids and type 2 diabetes: evidence of efficacy in clinical and animal studies and delivery strategies to enhance their therapeutic efficacy. Pharmacol Res. 2020;152:104629. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.phrs.2020.104629.\nGupta MK, Vadde R. Identification and characterization of differentially expressed genes in type 2 diabetes using in silico approach. Comput Biol Chem. 2019;79:24–35. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.compbiolchem.2019.01.010.\nChoi C. Astaxanthin as a peroxisome proliferator-activated receptor (PPAR) modulator: its therapeutic implications marine drugs. 2019;17(242):1–12. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fmd17040242.\nTorres-Espínola FJ, Altmäe S, Segura MT, Jerez A, Anjos T, Chisaguano M, López-Sabater MC, Entrala C, Alvarez JC, Agil A, Florido J, Catena A, Pérez-García M, Campoy C. Maternal PPARG Pro12Ala polymorphism is associated with infant's neurodevelopmental outcomes at 18 months of age. Early Hum Dev. 2015;91:457–62. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.earlhumdev.2015.05.001.\nSaeidi S, Chamaie-Nejad F, Ebrahimi A, Najafi F, Rahimi Z, Vaisi-Raygani A, Shakiba E, Rahimi Z. PPARγ Pro12Ala and C161T polymorphisms in patients with acne vulgaris: contribution to lipid and lipoprotein profile. Advances in Medical Sciences. 2018;63(1):147–51. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.advms.2017.09.003.\nKhodaeian M, Enayati S, Tabatabaei-Malazy O, Amoli MM. Association between genetic variants and diabetes mellitus in Iranian populations: a systematic review of observational studies. Journal of Diabetes Research. 2015; 2015 585917. 10.1155\u002F2015\u002F585917\nGravand A, Foroughmand AM, Boroujeni MP. A study on the association of TCF7L2 rs11196205 (C\u002FG) and CAPN10 rs3792267 (G\u002FA) polymorphisms with type 2 diabetes mellitus in the South Western of Iran. The Egyptian Journal of Medical Human Genetics. 2018;19:403–7. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ejmhg.2018.01.007.\nSun J, Hong J, Sun S, Wang X, Peng Y, Zhou J, Huang Y, Li S, Chen W, Li C, Xu K, Ye W. Transcription factor 7-like 2 controls matrix degradation through nuclear factor κB signaling and is repressed by microRNA-155 in nucleus pulposus cells. Biomed Pharmacother. 2018;108:646–55. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.biopha.2018.09.076.\nGupta B, Singh SK. Association of aldose reductase gene polymorphism (C-106T) in susceptibility of diabetic peripheral neuropathy among north Indian population. J Diabetes Complicat. 2017;31:1085–9. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jdiacomp.2017.04.011.\nHaghvirdizadeh P, Mohamed Z, Abdullah NA, Haghvirdizadeh P, Haerian MS, Haerian BS. KCNJ11: genetic polymorphisms and risk of diabetes mellitus. Journal of Diabetes Research. 2015; 2015: ID 908152. doi: https:\u002F\u002Fdoi.org\u002F10.1155\u002F2015\u002F908152\nVan Hoek M, Dehghan A, Witteman JC, Van Duijn CM, Uitterlinden AG, Oostra BA, Albert Hofman A, Sijbrands EJG, Janssens ACJ. Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study. Diabetes. 2008;57(11):3122–8. https:\u002F\u002Fdoi.org\u002F10.2337\u002Fdb08-0425.\nBisse E, Abraham EC. New less temperature-sensitive microchromatographic method for the separation and quantitation of glycosylated hemoglobins using a non-cyanide buffer system. J Chromatogr B Biomed Sci Appl. 1985;344:81–91. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0378-4347(00)82009-5.\nCoresh J, Astor BC, Greene T, Eknoyan G, Levey AS. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: third national health and nutrition examination survey. Am J Kidney Dis. 2003;41(1):1–12. https:\u002F\u002Fdoi.org\u002F10.1053\u002Fajkd.2003.50007.\nHabalová V, Klimčáková L, Židzik J, Tkáč I. Rapid and cost effective genotyping method for polymorphisms in PPARG, PPARGC1 and TCF7L2 genes. Mol Cell Probes. 2009;23(1):52–4. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.mcp.2008.10.001.\nRicheti F, Noronha RM, Waetge RTL, de Vasconcellos JPC, de Souza OF, Kneipp B, Assis N, Rocha MN, Calliari LEP, Longui CA, Monte O, de Melo MB. Evaluation of AC (n) and C (−106) T polymorphisms of the aldose reductase gene in Brazilian patients with DM1 and susceptibility to diabetic retinopathy. Mol Vis. 2007;13:740–5.\nDongxia L, Qi H, Lisong L, Jincheng G. Association of peroxisome proliferator-activated receptorgamma gene Pro12Ala and C161T polymorphisms with metabolic syndrome. Circ J. 2008;72(4):551–7. https:\u002F\u002Fdoi.org\u002F10.1253\u002Fcircj.72.551.\nTamarai K, Bhatti JS, Reddy PH. Molecular and cellular bases of diabetes: focus on type 2 diabetes mouse model-TallyHo. Biochim Biophys Acta (BBA) - Mol Basis Dis. 2019;1865:2276–84. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.bbadis.2019.05.004.\nJoensen LE, Madsen KP, Frimodt-Møller M, Tofte N, Willaing I, Lindhardt M, Rossing P. Changes in diabetes distress among people with type 2 diabetes during a risk screening programme for diabetic kidney disease–longitudinal observations of the PRIORITY study. J Diabetes Complicat. 2020;34(1):107467. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jdiacomp.2019.107467.\nSami W, Ansari T, Butt NS, Ab Hamid MR. Effect of diet on type 2 diabetes mellitus: a review. Int J Health Sci (Qassim). 2017;11(2):65–71.\nBlanter M, Sork H, Tuomela S, Flodström-Tullberg M. Genetic and Environmental Interaction in Type 1 Diabetes: a Relationship Between Genetic Risk Alleles and Molecular Traits of Enterovirus Infection? Current Diabetes Reports. 2019;19(9):82. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11892-019-1192-8.\nCuschieri S. The genetic side of type 2 diabetes–a review. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2019;13(4):2503–6. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.dsx.2019.07.012.\nJihan AM, Seham MA, Hamdia EA, Eman SM. Relationship between Diabetic Retinopathy and Methylenetetrahydrofolate Reductase Gene Polymorphism. Egyptian Journal of Hospital Medicine. 2017;67(2): 628–634. 10.12816\u002F0037814\nChutani A, Pande S. Correlation of serum creatinine and urea with glycemic index and duration of diabetes in type 1 and type 2 diabetes mellitus: a comparative study. National Journal of Physiology, Pharmacy and Pharmacology. 2017;7(9):914–9. https:\u002F\u002Fdoi.org\u002F10.5455\u002Fnjppp.2017.7.0515606052017.\nElhefnawy KA, Elsayed AM. Prevalence of diabetic kidney disease in patients with type 2 diabetes mellitus. The Egyptian Journal of Internal Medicine. 2019;31(2):149–54. https:\u002F\u002Fdoi.org\u002F10.4103\u002Fejim.ejim_113_18.\nZhou M, He S, Ping F, Li W, Zhu L, Cui X, Feng L, Zhao X, Zhang H, Li Y, Sun Q. Uncoupling Protein 2 and Peroxisome Proliferator-Activated Receptor γ Gene Polymorphisms in Association with Diabetes Susceptibility in Chinese Han Population with Variant Glucose Tolerance. International journal of endocrinology. 2018;2018, 1–16. 10.1155\u002F2018\u002F4636783\nLv X, Zhang L, Sun J, Cai Z, Gu Q, Zhang R, Shan A. Interaction between peroxisome proliferator-activated receptor gamma polymorphism and obesity on type 2 diabetes in a Chinese Han population. Diabetology & Metabolic Syndrome. 2017;9(1):1–6. 10.1186\u002Fs13098-017-0205-5 PMID: 28123453\nVergotine Z, Kengne AP, Erasmus RT, Yako YY, Matsha TE. Rare mutations of peroxisome proliferator-activated receptor gamma: frequencies and relationship with insulin resistance and diabetes risk in the mixed ancestry population from South Africa. International Journal of Endocrinology. 2014;2014, 1–8. 10.1155\u002F2014\u002F187985 PMID: 25197274.\nPattanayak AK, Bankura B, Balmiki N, Das TK, Chowdhury S, Das M. Role of peroxisome proliferator-activated receptor gamma gene polymorphisms in type 2 diabetes mellitus patients of West Bengal, India. J Diabetes Investig. 2014; 5(2): 188–191.. 10.1111\u002Fjdi.12130 PMID: 24843759\nDing S, Liu L, Zhuge QC, Yu Z, Zhang X, Xie J. The Meta-analysis of the association of PPARG P12A, C161T polymorphism and coronary heart disease. Wien Klin Wochenschr. 2012;124:671–7. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00508-012-0223-0.\nJiang J, Gajalakshmi V, Wang J, Kuriki K, Suzuki S, Nakamura S, Akasaka S, Ishikawa H, Tokudome S. Influence of the C161T but not Pro12Ala polymorphism in the peroxisome proliferator activated receptor gamma on colorectal cancer in an Indian population. Cancer Sci. 2005;96:507–12. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1349-7006.2005.00072.x.\nSiezen CL, van Leeuwen AI, Kram NR, Luken ME, van Kranen HJ, Kampman E. Colorectal adenoma risk is modified by the interplay between polymorphisms in arachidonic acid pathway genes and fish consumption. Carcinogenesis. 2005;26:449–57. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fcarcin\u002Fbgh336.\nShrestha UK, Karimi O, Crusius JB, Zhou F, Wang Z, Chen Z, van Bodegraven AA, Xiao, J, Morré SA, Wang H, Li J, Xia B Distribution of peroxisome proliferator-activated receptor-gamma polymorphisms in Chinese and Dutch patients with inflammatory bowel disease inflammatory bowel disease 2009;16(2): 312–319. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fibd.21059.\nChang K, Shieh B, Petrash JM. Role of aldose reductase in diabetes-induced retinal microglia activation. Chem Biol Interact. 2019;302:46–52. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.cbi.2019.01.020.\nMansour MM, El-Hussiny MA, Ghareeb NA, Marzouk HFA, Lumon NI. Serum 8-hydroxydeoxyguanosine and aldose reductase C-106T polymorphism in type 2 diabetes mellitus and its relation to complications in Egyptian patients. Comp Clin Pathol. 2018;27(1):99–105. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00580-017-2558-4.\nSivenius K, Pihlajamäki J, Partanen J, Niskanen L, Laakso M, Uusitupa M. Aldose reductase gene polymorphisms and peripheral nerve function in patients with type 2 diabetes. Diabetes Care. 2004;27(8):2021–6. https:\u002F\u002Fdoi.org\u002F10.2337\u002Fdiacare.27.8.2021.\nWatarai A, Nakashima E, Hamada Y, Watanabe G, Naruse K, Miwa K, Kobayashi Y, Kamiya H, Nakae M, Hamajima N, Sekido Y, Niwa T, Oiso Y, Nakamura J. Aldose reductase gene is associated with diabetic macroangiopathy in Japanese type 2 diabetic patients. Diabetic Medicine. 2006;23(8): 894–899. 10.1111\u002Fj.1464-5491.2006.01946.x.\nShen J, Fang Y, Ge W. Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with impaired proinsulin conversion--a meta-analysis. Diabetes Res Clin Pract. 2015;109(1):117–23. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.diabres.2015.04.020.\nFacchinello N, Tarifeño-Saldivia E, Grisan E, Schiavone M, Peron M, Mongera A, Ek O, Schmitner N, Meyer D, Peers B, Tiso N, Argenton F. Tcf7l2 plays pleiotropic roles in the control of glucose homeostasis, pancreas morphology, vascularization and regeneration. Sci Rep. 2017;7(1):9605. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41598-017-09867-x.\nAbd El Razek NY, Wissa NR, Nassar HM, Omar SA. Association of RS 7903146 (C\u002FT) Single Nucleotide Polymorphism at Transcription Factor 7 Like 2 Gene with Type 2 Diabetes Mellitus in Egyptian Patients. Suez Canal University Medical Journal. 2016; 19(1): 29–38. 10.21608\u002FSCUMJ.2016.43911\nWelter M, Frigeri HR, Souza EM, Souza ALF, Alberton D, Picheth G, Rego FGM. Polymorphisms in the Fat Mass and Obesity Associated (FTO) and Transcription factor 7-like 2 (TCF7L2) genes in Euro-Brazilian individuals with type 2 diabetes. Diabetes, Obesity & Metabolic Disorders Open Access. 2016;2: 1–6. ID: 52214790.\nPourahmadi M, Erfanian S, Moradzadeh M, Jahromi AS. Non-association between rs7903146 and rs12255372 polymorphisms in transcription factor 7-like 2 gene and type 2 diabetes mellitus in Jahrom City, Iran. Diabetes & Metabolism Journal. 2015; 39(6): 512–517. 10.4093\u002Fdmj.2015.39.6.512.\nBarseem NF. El- Samalehy MF, Kasemy ZA. Transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism, association with type 2 diabetes mellitus susceptibility. J Obes Weight Loss Ther. 2015;5(1):1–7. https:\u002F\u002Fdoi.org\u002F10.4172\u002F2165-7904.1000250.\nEl-Lebedy D, Ashmawy I. Common variants in TCF7L2 and CDKAL1 genes and risk of type 2 diabetes mellitus in Egyptians. J Genet Eng Biotechnol. 2016; 14(2): 247–251. 10.1016\u002Fj.jgeb.2016.10.004.\nIbrahim AT, Hussain A, Salih MA, Ibrahim OA, Jamieson SE, Ibrahim ME, Blackwell JM, Mohamed HS. Candidate gene analysis supports a role for polymorphisms at TCF7L2 as risk factors for type 2 diabetes in Sudan. Journal of Diabetes & Metabolic Disorders. 2015; 15(1): 4. 10.1186\u002Fs40200-016-0225-y.\nDemirsoy IH, Aras N, Cinkir U. TCF7L2 rs7903146 gene variation is associated with risk of type 2 diabetes in Turkish population. Journal of Clinical & Medical Genomics. 2016;4(2):1–3. https:\u002F\u002Fdoi.org\u002F10.4172\u002F2472-128X.1000141.\nDou H, Ma E, Yin L, Jin Y, Wang H. The association between gene polymorphism of TCF7L2 and type 2 diabetes in Chinese Han population: a meta-analysis. PloS one. 2013; 8(3):e59495. 10.1371\u002Fjournal.pone.0059495.\nDing W, Xu L, Zhang L, Han Z, Jiang Q, Wang Z, Jin S. Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus. BMC Med Genet. 2018; 19 (38): 1–12. 10.1186\u002Fs12881-018-0553-5.\nMandour I, Darwish R, Fayez R, Naguib M, El-Sayegh S. TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus, a pilot study. Biomedical & Pharmacology Journal. 2018;11(2):1043–9. https:\u002F\u002Fdoi.org\u002F10.13005\u002Fbpj\u002F1465.\nVerma S, Srivastava N, Banerjee M. PS 04-25 association of tcf7l2 and ppar [gamma] gene variants with type 2 diabetes mellitus in north indian population. J Hypertens. 2016;34:e139–40. https:\u002F\u002Fdoi.org\u002F10.1097\u002F01.hjh.0000500259.57616.2a.\nGuewo-Fokeng M, Sobngwi E, Atogho-Tiedeu B, Donfack OS, Noubiap JJN, Ngwa EN, Mato-Mofo EP, Fosso PP, Djahmeni E, Djokam-Dadjeu R , Evehe M, Aminkeng F 5, Mbacham WF, Mbanya JC. Contribution of the TCF7L2 rs7903146 (C\u002FT) gene polymorphism to the susceptibility to type 2 diabetes mellitus in Cameroon. Journal of Diabetes & Metabolic Disorders. 2015; 14: 1. 10.1186\u002Fs40200-015-0148-z\nYousef AA, Behiry EG, Abd Allah WM, Hussien AM, Abdelmoneam AA, Imam MH, Hikal DM. IRS-1 genetic polymorphism (r. 2963G> A) in type 2 diabetes mellitus patients associated with insulin resistance. The application of clinical genetics. 2018; 11: 99–106. 10.2147\u002FTACG.S171096.\nLin S, Peng Y, Cao M, Chen R, Hu J, Pu Z, Cai Z, Mou L. Association between aldose reductase gene C (−106) T polymorphism and diabetic retinopathy: a systematic review and Meta-analysis. Ophthalmic Res. 2020;63(3):224–33. https:\u002F\u002Fdoi.org\u002F10.1159\u002F000503972.",{"VOID":1206},"10.1007\u002Fs40200-021-00963-4","https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs40200-021-00963-4",[1209,1233,1248,1261,1274],{"id":1210,"sortIndex":32,"researcher":28,"roles":1211,"affiliations":1212,"properties":1230,"displayName":1232,"givenName":28,"familyName":28},"2823fbb1-8934-49c5-b92d-8009f35b0b70",[978],[1213,1221],{"id":1214,"sortIndex":32,"affiliation":1215,"properties":28},"69096522-2f2d-489d-8cb4-787a72a4130a",{"id":1214,"createTime":28,"updateTime":28,"relativeEntities":1216,"slug":28,"properties":1217,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1220,"statistic":28},[],{"title":1218},{"VI":1219},"Biochemistry Division, Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt",[],{"id":1222,"sortIndex":40,"affiliation":1223,"properties":1229},"29789e29-bf49-4194-8ae3-a87880921ff9",{"id":1222,"createTime":28,"updateTime":28,"relativeEntities":1224,"slug":28,"properties":1225,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1228,"statistic":28},[],{"title":1226},{"VI":1227},"Mansoura Ophthalmic Center, Mansoura University, Mansoura, Egypt",[],{},{"title":1231},{"VI":1232},"Hadeel Ahmed Shawki",{"id":1234,"sortIndex":40,"researcher":28,"roles":1235,"affiliations":1236,"properties":1245,"displayName":1247,"givenName":28,"familyName":28},"f0568bab-6140-44b6-abd9-139eecad673f",[978],[1237],{"id":1238,"sortIndex":32,"affiliation":1239,"properties":28},"8d408113-3725-4c6f-a2fc-18b143f7d533",{"id":1238,"createTime":28,"updateTime":28,"relativeEntities":1240,"slug":28,"properties":1241,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1244,"statistic":28},[],{"title":1242},{"EN":1243},"Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt",[],{"title":1246},{"VI":1247},"Ekbal M. Abo-hashem",{"id":1249,"sortIndex":123,"researcher":28,"roles":1250,"affiliations":1251,"properties":1258,"displayName":1260,"givenName":28,"familyName":28},"844f5990-4f32-4554-902f-d36d54a153b6",[978],[1252],{"id":1214,"sortIndex":32,"affiliation":1253,"properties":28},{"id":1214,"createTime":28,"updateTime":28,"relativeEntities":1254,"slug":28,"properties":1255,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1257,"statistic":28},[],{"title":1256},{"VI":1219},[],{"title":1259},{"VI":1260},"Magdy M. 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examine the longitudinal relationship between the age or shelf-life of common type 2 diabetes laboratory tests for serum creatinine, cholesterol, and glycated hemoglobin A1c conducted in outpatient settings and subsequent inpatient hospitalizations and emergency department visits. This study analyzes panel data from two healthcare delivery systems’ electronic health records (EHR) for patients aged 18 years and older managing type 2 diabetes. We used EHR data to quantify the age of three laboratory tests: serum creatinine, cholesterol, and glycated hemoglobin A1c. Encounter data were used to determine the frequency of inpatient hospitalizations and emergency department visits. Negative binomial regressions with fixed effects were performed to compute marginal effects, levels of statistical significance, and 95% confidence intervals. The average age for serum creatinine laboratory tests was 1.51 months (95%CI: 1.49–1.53). We computed older average ages for hemoglobin A1c (mean:6.17 months; 95%CI: 6.11–6.23) and serum creatinine tests (mean: 8.73; 95%CI: 8.65–8.81). Older laboratory tests were associated with an increase in the total expected counts of subsequent inpatient hospitalizations (ME = 0.047; p \u003C 0.001) and ED visits (ME = 0.034; p \u003C 0.001). Findings from this study indicate that older type 2 diabetes laboratory tests are associated with increases in the total expected count of subsequent inpatient hospitalizations and emergency department visits. Future research should examine the actionability of laboratory test values to determine associations with healthcare outcomes.",{"EN":1351},"Associations between Outpatient Laboratory Test Age and Healthcare Utilization in Type 2 Diabetes Care",{"VOID":1353},"Panser LA, Naessens JM, Nobrega FT, Palumbo PJ, Ballard DJ. Utilization trends and risk factors for hospitalization in diabetes mellitus. Mayo Clin Proc. 1990;65(9):1171–84.\nRosenthal MJ, Fajardo M, Gilmore S, Morley JE, Naliboff BD. Hospitalization and mortality of diabetes in older adults. A 3-year prospective study. Diabetes Care. 1998;21(2):231–5.\nPippitt K, Li M, Gurgle HE. Diabetes Mellitus: Screening and Diagnosis. Published January 15, 2016. Accessed March 12, 2022. https:\u002F\u002Fwww.aafp.org\u002Fafp\u002F2016\u002F0115\u002Fp103.html.\nUS Preventive Services Task Force, Davidson KW, Barry MJ, et al. Screening for Prediabetes and Type 2 diabetes: US Preventive Services Task Force Recommendation Statement. JAMA. 2021;326(8):736–43.\nHess R, Bryce CL, Paone S, et al. Exploring challenges and potentials of personal health records in diabetes self-management: implementation and initial assessment. Telemed J E Health. 2007;13(5):509–17.\nVo MT, Uratsu CS, Estacio KR, et al. Prompting patients with poorly controlled diabetes to identify visit Priorities before Primary Care visits: a pragmatic cluster Randomized Trial. J Gen Intern Med. 2019;34(6):831–8.\nDusheiko M, Doran T, Gravelle H, Fullwood C, Roland M. Does higher quality of diabetes management in family practice reduce unplanned hospital admissions? Health Serv Res. 2011;46(1 Pt 1):27–46.\nNelson LA, Wallston KA, Kripalani S, LeStourgeon LM, Williamson SE, Mayberry LS. Assessing barriers to diabetes medication adherence using the information-motivation-behavioral skills model. Diabetes Res Clin Pract. 2018;142:374–84.\nBowen ME, Merchant Z, Abdullah K, Bhat D, Fish J, Halm EA. Patient, provider, and System factors Associated with failure to Follow-Up elevated glucose results in patients without diagnosed diabetes. Health Serv Res Manag Epidemiol. 2017;4:2333392817721647.\nO’Connor PJ. Organizing diabetes care: identify, monitor, prioritize, intensify. Diabetes Care. 2001;24(9):1515–6.\nFrancis BH, Song X, Andrews LM, et al. Progression to type 2 diabetes, healthcare utilization, and cost among pre-diabetic patients with or without comorbid hypertension. Curr Med Res Opin. 2011;27(4):809–19.\nChouvarda IG, Goulis DG, Lambrinoudaki I, Maglaveras N. Connected health and integrated care: toward new models for chronic disease management. Maturitas. 2015;82(1):22–7.\nLiaw ST, Rahimi A, Ray P, et al. Towards an ontology for data quality in integrated chronic disease management: a realist review of the literature. Int J Med Inform. 2013;82(1):10–24.\nShahraz S, Pittas AG, Saadati M, Thomas CP, Lundquist CM, Kent DM. Change in testing, awareness of Hemoglobin A1c result, and Glycemic Control in US adults, 2007–2014. JAMA. 2017;318(18):1825–7.\nComino EJ, Harris MF, Islam MDF, et al. Impact of diabetes on hospital admission and length of stay among a general population aged 45 year or more: a record linkage study. BMC Health Serv Res. 2015;15:12.\nSamuels TA, Cohen D, Brancati FL, Coresh J, Kao WHL. Delayed diagnosis of incident type 2 diabetes mellitus in the ARIC study. Am J Manag Care. 2006;12(12):717–24.\nPatel V, McNamara L, Dullabh P, Sawchuk ME, Swain M. Variation in interoperability across clinical laboratories nationwide. Int J Med Inform. 2017;108:175–84.\nGazmararian JA, Ziemer DC, Barnes C. Perception of barriers to self-care management among diabetic patients. Diabetes Educ. 2009;35(5):778–88.\nDelaronde S. Barriers to A1C testing among a managed care population. Diabetes Educ. 2005;31(2):235–9.\nMcDonald CJ, Overhage JM, Barnes M, et al. The Indiana network for patient care: a working local health information infrastructure. An example of a working infrastructure collaboration that links data from five health systems and hundreds of millions of entries. Health Aff. 2005;24(5):1214–20.\nHills RA, Revere D, Altamore R, Abernethy NF, Lober WB. Timeliness and data element completeness of immunization data in Washington State in 2010: a comparison of data exchange methods. AMIA Annu Symp Proc. 2012;2012:340–349.\nStata. Accessed February 3, 2023. https:\u002F\u002Fwww.stata.com\u002Fsupport\u002Ffaqs\u002Fresources\u002Fciting-software-documentation-faqs\u002F.\nHu Z, Melton GB, Arsoniadis EG, Wang Y, Kwaan MR, Simon GJ. Strategies for handling missing clinical data for automated surgical site infection detection from the electronic health record. J Biomed Inform. 2017;68:112–20.\nGoel MS, Brown TL, Williams A, Hasnain-Wynia R, Thompson JA, Baker DW. Disparities in enrollment and use of an electronic patient portal. J Gen Intern Med. 2011;26(10):1112–6.\nShrivastav M, Gibson W Jr, Shrivastav R, et al. Type 2 Diabetes Management in Primary Care: the role of Retrospective, Professional continuous glucose monitoring. Diabetes Spectr. 2018;31(3):279–87.\nBell SK, Delbanco T, Elmore JG, et al. Frequency and types of patient-reported errors in Electronic Health Record Ambulatory Care Notes. JAMA Netw Open. 2020;3(6):e205867–7.\nFaulconer ER, de Lusignan S. An eight-step method for assessing diagnostic data quality in practice: chronic obstructive pulmonary disease as an exemplar. Inf Prim Care. 2004;12(4):243–54.\nBotsis T, Hartvigsen G, Chen F, Weng C. Secondary Use of EHR: Data Quality Issues and Informatics Opportunities. AMIA Jt Summits Transl Sci Proc. 2010;2010:1–5.\nGoudswaard AN, Lam K, Stolk RP, Rutten GEHM. Quality of recording of data from patients with type 2 diabetes is not a valid indicator of quality of care. A cross-sectional study. Fam Pract. 2003;20(2):173–7.\nHeinrich B, Kaiser M, HOW TO MEASURE DATA QUALITY?. A METRIC BASED APPROACH. Twenty Eighth International Conference on Information Systems,. Published online 2007. https:\u002F\u002Fepub.uni-regensburg.de\u002F23633\u002F1\u002Fheinrich.pdf.\nCappiello C, Francalanci C, Pernici B. Time-Related factors of Data Quality in Multichannel Information Systems. J Manage Inform Syst. 2003;20(3):71–92.\nCappiello C, Francalanci C, Pernici B. Data quality assessment from the user’s perspective. In: Proceedings of the 2004 International Workshop on Information Quality in Information Systems. IQIS ’04. Association for Computing Machinery; 2004:68–73.\nSteiner C, Barrett M, Hunter K. Hospital Readmissions and multiple Emergency Department visits, in selected States, 2006–2007: statistical brief #90. Healthcare cost and utilization project (HCUP) statistical briefs. Agency for Healthcare Research and Quality (US); 2010.\nBo S, Ciccone G, Grassi G, et al. Patients with type 2 diabetes had higher rates of hospitalization than the general population. J Clin Epidemiol. 2004;57(11):1196–201.\nLi Y, Sperrin M, Martin GP, Ashcroft DM, van Staa TP. Examining the impact of data quality and completeness of electronic health records on predictions of patients’ risks of cardiovascular disease. Int J Med Inform. 2020;133:104033.",{"VOID":1355},"10.1007\u002Fs40200-023-01250-0","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs40200-023-01250-0",[1358,1373,1388,1403,1416,1431],{"id":1359,"sortIndex":32,"researcher":28,"roles":1360,"affiliations":1361,"properties":1370,"displayName":1372,"givenName":28,"familyName":28},"cf9a8684-695b-4e3b-9d7b-279cc11cc4c6",[978],[1362],{"id":1363,"sortIndex":32,"affiliation":1364,"properties":28},"8190313e-61cb-4aee-ae5d-cfccd638ec74",{"id":1363,"createTime":28,"updateTime":28,"relativeEntities":1365,"slug":28,"properties":1366,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1369,"statistic":28},[],{"title":1367},{"VI":1368},"Department of Healthcare Leadership and Management, Medical University of South Carolina (MUSC), Charleston, USA",[],{"title":1371},{"VI":1372},"Kevin Wiley",{"id":1374,"sortIndex":40,"researcher":28,"roles":1375,"affiliations":1376,"properties":1385,"displayName":1387,"givenName":28,"familyName":28},"f5f42a94-8f1f-40c9-8bb4-731db5748518",[978],[1377],{"id":1378,"sortIndex":32,"affiliation":1379,"properties":28},"6f871177-f325-4898-ab82-e563820cbcd8",{"id":1378,"createTime":28,"updateTime":28,"relativeEntities":1380,"slug":28,"properties":1381,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1384,"statistic":28},[],{"title":1382},{"VI":1383},"Department of Health Policy and Management Richard M. Fairbanks School of Public Health, Indiana University Indianapolis, Indianapolis, USA",[],{"title":1386},{"VI":1387},"Justin Blackburn",{"id":1389,"sortIndex":123,"researcher":28,"roles":1390,"affiliations":1391,"properties":1400,"displayName":1402,"givenName":28,"familyName":28},"f7698035-0400-41fe-9274-9053c570c998",[978],[1392],{"id":1393,"sortIndex":32,"affiliation":1394,"properties":28},"2097e53f-67e9-4307-8244-7af7616fc1fe",{"id":1393,"createTime":28,"updateTime":28,"relativeEntities":1395,"slug":28,"properties":1396,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1399,"statistic":28},[],{"title":1397},{"VI":1398},"University of Cincinnati, Cincinnati, USA",[],{"title":1401},{"VI":1402},"Eneida Mendonca",{"id":1404,"sortIndex":42,"researcher":28,"roles":1405,"affiliations":1406,"properties":1413,"displayName":1415,"givenName":28,"familyName":28},"5334864b-9fe6-4672-aaec-10d67dd33c49",[978],[1407],{"id":1378,"sortIndex":32,"affiliation":1408,"properties":28},{"id":1378,"createTime":28,"updateTime":28,"relativeEntities":1409,"slug":28,"properties":1410,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1412,"statistic":28},[],{"title":1411},{"VI":1383},[],{"title":1414},{"VI":1415},"Nir Menachemi",{"id":1417,"sortIndex":45,"researcher":28,"roles":1418,"affiliations":1419,"properties":1428,"displayName":1430,"givenName":28,"familyName":28},"0d1bbe77-8a46-49f9-bfec-6809de1b79e4",[978],[1420],{"id":1421,"sortIndex":32,"affiliation":1422,"properties":28},"5ab16873-c1f2-4dee-b6b9-4c95c09ad637",{"id":1421,"createTime":28,"updateTime":28,"relativeEntities":1423,"slug":28,"properties":1424,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1427,"statistic":28},[],{"title":1425},{"VI":1426},"Diabetes Translational Research Center, School of Medicine, Indiana University, Bloomington, United States",[],{"title":1429},{"VI":1430},"Mary De Groot",{"id":1432,"sortIndex":46,"researcher":28,"roles":1433,"affiliations":1434,"properties":1441,"displayName":1443,"givenName":28,"familyName":28},"7cc9dacc-9461-47ae-ad99-34167ee5cb0f",[978],[1435],{"id":1378,"sortIndex":32,"affiliation":1436,"properties":28},{"id":1378,"createTime":28,"updateTime":28,"relativeEntities":1437,"slug":28,"properties":1438,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1440,"statistic":28},[],{"title":1439},{"VI":1383},[],{"title":1442},{"VI":1443},"Joshua R. Vest",{"url":1356,"publisher":1445,"properties":1490},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1446,"slug":872,"properties":1447,"entityType":25,"verifyStatus":878,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1450,"manageAffiliations":1459,"indexDatabases":1470,"url":932,"thumbnailPath":28,"statistic":1485,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1448,"title":1449},{"VOID":875},{"EN":877},[1451,1455],{"id":881,"createTime":28,"updateTime":28,"relativeEntities":1452,"label":1453,"description":1454,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":884},{},{"id":887,"createTime":28,"updateTime":28,"relativeEntities":1456,"label":1457,"description":1458,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},[1460,1465],{"id":894,"createTime":28,"updateTime":28,"relativeEntities":1461,"slug":28,"properties":1462,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1464,"statistic":28},[],{"title":1463},{"EN":898},[],{"id":901,"createTime":28,"updateTime":28,"relativeEntities":1466,"slug":28,"properties":1467,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1469,"statistic":28},[],{"title":1468},{"EN":905},[907],[1471,1478],{"id":910,"indexDatabase":1472,"url":916,"indexYears":28,"academicFieldIds":1477,"indexDatabaseRanking":28},{"id":803,"createTime":28,"updateTime":28,"relativeEntities":1473,"label":1474,"description":1475,"key":810,"publicationTags":1476,"standard":28},[],{"EN":806,"VI":806},{"EN":808,"VI":809},[812,813],[918],{"id":920,"indexDatabase":1479,"url":926,"indexYears":927,"academicFieldIds":1484,"indexDatabaseRanking":931},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":1480,"label":1481,"description":1482,"key":781,"publicationTags":1483,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[929,930],{"impactFactor":32,"impactFactorByYear":1486,"i10Index":162,"i10IndexLast5Year":135,"totalPublication":936,"totalPublicationByYear":1487,"totalCitation":941,"totalCitationByYear":1488,"totalCitationPerPublication":344,"totalCitationPerPublicationByYear":1489,"hindexLast5Year":135,"hindex":135},{"2017":106,"2018":121,"2019":423,"2020":319,"2021":935,"2022":935,"2023":117},{"2012":51,"2013":138,"2014":208,"2015":689,"2016":132,"2017":142,"2018":148,"2019":560,"2020":938,"2021":939,"2022":938,"2023":940,"2024":131},{"2015":161,"2016":132,"2017":938,"2018":196,"2019":943,"2020":944,"2021":566,"2022":516},{"2015":585,"2016":40,"2017":946,"2018":947,"2019":948,"2020":949,"2021":950,"2022":951},{"pages":1491,"volume":1493},{"VOID":1492},"1319-1326",{"VOID":1188},"2023-07-01",[931,812],{"id":1497,"createTime":1498,"updateTime":1499,"relativeEntities":1500,"slug":1501,"properties":1502,"entityType":971,"verifyStatus":26,"verifyTime":1499,"verifyNote":972,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1511,"fullTextUrl":28,"authors":1512,"publicationType":1035,"publisherRelationship":1588,"citationCount":28,"citationInfo":28,"publishDate":1638,"publishYear":1190,"citationAnalyzeStatus":878,"lastCitationAnalyze":28,"indexDatabases":1639,"openAccess":28,"references":28,"isForceReanalyzing":1090},"018cf7e0-6e86-4ca2-935f-c18a848b3117","2023-12-26T06:23:14.276+00:00","2025-01-01T09:09:19.123+00:00",[],"The-diabetic-patient-between-sustainability-and-effectiveness-of-new-treatments",{"abstract":1503,"title":1505,"references":1507,"doi":1509},{"EN":1504},"The increased issuance and distribution of new agents for type 2 diabetes mellitus, due to relaxed prescribing rules, has resulted not only in a greater proximity of treatments to the patient, as envisioned by post-Covidio 19 European policies, but also in an unexpected increase in healthcare spending. An analysis of a database called “Health Card” was performed in order to evaluate all prescriptions for the new classes of medications used for type 2 diabetes. New legislation called “note 100” was introduced in early 2022, outlining the eligibility of certain categories of drugs used for the treatment of type 2 diabetes mellitus for direct prescription by primary care physicians in Italy. This investigation therefore delves into an examination of the prescribing patterns related to these drugs, contrasting the year 2021, prior to the implementation of Note 100, with the year 2022, following the incorporation of the new legislation. The result resulted in an exponential increase in prescriptions and consumption (+ 38%) and increased healthcare spending of more than three million euros for these drug categories. This analysis highlights how regulation on the one hand leads to facilitating prescribing to meet a population need that is not fully satisfied, but on the other hand leads to increased prescribing and increased health care expenditures that may likely mask phenomena of prescribing inappropriateness.",{"EN":1506},"The diabetic patient between sustainability and effectiveness of new treatments",{"VOID":1508},"Associazione Medici Diabetologi (AMD)-Italian Society of Diabetology (SID). Italian Standards for the Care of Diabetes Mellitus 2018, http:\u002F\u002Fwww.siditalia.it\u002Fclinica\u002Fstandards-of-care-amd-sid. Accessed Oct 2022.\nGuideline of the Italian Society of Diabetology (SID) and the Association of Medical Diabetologists (AMD). The treatment of type 2 diabetes mellitus. https:\u002F\u002Fwww.iss.it\u002Fsnlg-copertina.\nTsapas A, Avgerinos I, Karagiannis T, et al. Comparative efficacy of glucoselowering drugs for type 2 diabetes. Ann Intern Med. 2020;173:278–86. https:\u002F\u002Fdoi.org\u002F10.7326\u002FM20-0864.\nThe International Hypoglycaemia Study Group. Hypoglycaemia, cardiovascular disease, and mortality in diabetes: epidemiology, pathogenesis, and management. Lancet Diabetes Endocrinol. 2019;7(18):385–96. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS2213.\nBilgin S, Kurtkulagi O, Atak Tel BM, Duman TT, Kahveci G, Khalid A, Aktas G. Does C-reactive protein to serum albumin ratio correlate with diabEtic nephropathy in patients with type 2 dIabetes MEllitus? The CARE TIME study. Prim Care Diabetes. 2021;15(6):1071–4. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.pcd.2021.08.015.\nÖberg K. Expert Review of Endocrinology & metabolism: major coverage of the advances in an expanding field. Expert Rev Endocrinol Metab. 2006;1(1):1–2. https:\u002F\u002Fdoi.org\u002F10.1586\u002F17446651.1.1.1.\nBilgin S, Kurtkulagi O, Duman TT, Tel BMA, Kahveci G, Kiran M, Erge E, Aktas G. Sodium glucose co-transporter-2 inhibitor, Empagliflozin, is associated with significant reduction in weight, body mass index, fasting glucose, and A1c levels in type 2 diabetic patients with established coronary heart disease: the SUPER GATE study. Ir J Med Sci. 2022;191(4):1647–52. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11845-021-02761-6.\nPalmer SC, Tendal B, Mustafa RA, et al. Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials. BMJ. 2021;372: m4573. https:\u002F\u002Fdoi.org\u002F10.1136\u002Fbmj.m4573.\nZhu J, Xiaoxia Y, Zheng Y, et al. Association of glucose-lowering medications with cardiovascular outcomes: an umbrella review and evidence map. Lancet Diabetes Endocrinol. 2020;8:192–205. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS2213-8587(19)30422-X.\nKristensen SL, Rorth R, Jhund PS, et al. Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials. Lancet Diabetes Endocrinol. 2019;7:776–85. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS2213-8587(19)30249-9.\nNeuen L, Young T, Heerspink HJL, et al. SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinology. 2019;7:845–54. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS2213-8587(19)30256-6.\nCherney DZI, Dagogo-Jack S, McGuire DK, et al. On the behalf of the VERTIS CV Investigators. Kidney outcomes using a sustained ≥ 40% decline in eGFR: a metaanalysis of SGLT2 inhibitor trials. Clin Cardiol. 2021;44:1139–43. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fclc.23665.\nPerkovic V, Jardine MJ, Neal B, et al. CREDENCE trial investigators. Canagliflozin and renal outcomes in type 2 diabetes and nephropathy. N Engl J Med. 2019;380:2295–306. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMoa2024816.\nHeerspink HJL, Stafansson BV, Correa-Rotter R, et al. For the DAPA-CKD trial committees and investigators. Dapagliflozin in patients with chronic kidney disease. N Engl J Med. 2020;383:1436–46.\nTaylor OM, Lam C. The effect of Dipeptidyl Peptidase-4 inhibitors on macrovascular and microvascular complications of diabetes mellitus: a systematic review. Curr Ther Res Clin Exp. 2020;25: 100596. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.curtheres.2020.100596.\nItalian Agency of Drugs AIFA. https:\u002F\u002Fwww.aifa.gov.it\u002Fnota-100. Accessed Dec 2022.\nItalian Agency of Drugs AIFA. https:\u002F\u002Fwww.aifa.gov.it\u002F-\u002Fattivazione-della-prescrizione-informatizzata-dei-farmaci-in-nota-100-da-parte-dei-medici-di-medicina-generale-tramite-il-sistema-ts. Accessed Dec 2022.\nSID AMD. Italian scientific society of diabetology. https:\u002F\u002Fwww.siditalia.it\u002F. Accessed Dec 2022.\nFerrara F, Santilli P, Bartolini L, Vitiello A, Pennacchia A, Di Croce S, D’Aiuto V. L’importanza del magazzino logistico in periodo di pandemia: l’esperienza dell’USL Umbria 1 durante covid-19 [The importance of the logistic warehouse in pandemic period: the experience of the USL Umbria 1 (Perugia, Italy) during covid-19]. Recenti Prog Med. 2021;112(3):219–24. https:\u002F\u002Fdoi.org\u002F10.1701\u002F3565.35462. (Italian).\nFerrara F, Santilli P, Vitiello A, Forte G, D’Aiuto V. Logistics management provides greater efficiency, governance and compliance. Int J Clin Pharm. 2021;43(5):1431–5. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11096-021-01283-6.\nFerrara F, Mancaniello C, Varriale A, Sorrentino S, Zovi A, Nava E, Trama U, Boccellino M, Vitiello A. COVID-19 mRNA vaccines: a Retrospective observational pharmacovigilance study. Clin Drug Investig. 2022;23:1–10. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs40261-022-01216-9.\nFerrara F, Nava L, Trama U, Nava E, Vitiello A. The slow path to Therapeutic Adherence. Hosp Pharm. 2022;57(5):593–5. https:\u002F\u002Fdoi.org\u002F10.1177\u002F00185787221074570.\nFerrara F, Mancaniello C, Nava L, Salierno A, Casillo R, Trama U, Nava E, Vitiello A. Could decreased reporting of suspected adverse reactions generate future safety concerns? Hosp Pharm. 2022;57(4):419–21. https:\u002F\u002Fdoi.org\u002F10.1177\u002F00185787211069040.\nInoue D, Nishi H, Inoue R, Nangaku M. Regional distribution of Cardiologists and prescription patterns of sodium-glucose Transporter-2 inhibitors in Japan. Int Heart J. 2021;62(3):592–600. https:\u002F\u002Fdoi.org\u002F10.1536\u002Fihj.20-716.\nFireman B, Toh S, Butler MG, Go AS, Joffe HV, Graham DJ, Nelson JC, Daniel GW, Selby JV. A protocol for active surveillance of acute myocardial infarction in association with the use of a new antidiabetic pharmaceutical agent. Pharmacoepidemiol Drug Saf. 2012;21(Suppl 1):282–90. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fpds.2337.\nJeong S, Ji E. Global perspectives on ensuring the safety of pharmaceutical products in the distribution process. Int J Clin Pharmacol Ther. 2018;56(1):12–23. https:\u002F\u002Fdoi.org\u002F10.5414\u002FCP203151.\nFerrara F, Vitiello A. Scientific hypothesis for treatment of COVID-19’s lung lesions by adjusting ACE\u002FACE2 imbalance. Cardiovasc Toxicol. 2021;21(6):498–503. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs12012-021-09649-y.\nFerrara F, Vitiello A. Potential pharmacological approach in the regulation of angiotensin-II conversion enzyme and dipeptidyl-peptidase 4 in diabetic COVID-19 patients. Italian J Med. 2021;15(1):53–5. https:\u002F\u002Fdoi.org\u002F10.4081\u002FITJM.2020.1435.\nJohnson LM, Levine D. Allocation of drugs in short supply. Virtual Mentor. 2013;15(8):645–8. https:\u002F\u002Fdoi.org\u002F10.1001\u002Fvirtualmentor.2013.15.8.ecas2-1308.\nCosentino F, Grant PJ, Aboyans V, et al. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J. 2020;41:255–323. https:\u002F\u002Fdoi.org\u002F10.1093\u002Feurheartj\u002Fehz486.\nGarber AJ, Handelsman Y, Grunberger G, et al. Consensus Statement by the American association of clinical endocrinologists and american college of endocrinology on the comprehensive type 2 diabetes management algorithm- 2020 executive summary. Endocr Pract. 2020;26:107–39.\nKidney Disease. Improving global outcomes (KDIGO) diabetes work group. KDIGO 2020 clinical practice guideline for diabetes management in chronic kidney disease. Kidney Int. 2020;98:1-S115.\nAmerican Diabetes Association. Pharmacologic approaches to glycemic treatment: standards of medical care in diabetes – 2021. 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Diabetes of the Young (MODY) is a monogenic form of diabetes, consisting of a heterogeneous group of autosomal dominant inherited disorders. Typical onset is in individuals prior to twenty five years, and presentation can mimic type 1 or 2 diabetes. Molecular genetic testing can allow precise identification of the different MODY sub-types. Making a specific diagnosis of MODY can have important implications for the guidance of appropriate treatment, prognosis and genetic counselling. We present the cases of three children and their families diagnosed with MODY over the past two years. These families highlight the features of three of the more common MODY subtypes, including two with novel mutations, one of which segregates in a kindred that is strongly affected by both MODY and classic autoimmune mediated diabetes. To date, we have identified a prevalence of MODY in the paediatric diabetes population of the lower South Island, New Zealand, of approximately 2.5%. This prevalence, along with increasing access to molecular genetic testing, highlights the importance of consideration of MODY in atypical diabetes presentations in the paediatric\u002Fadolescent population.",{"EN":1904},"Frequency and genetic spectrum of maturity-onset diabetes of the young (MODY) in southern New Zealand",{"VOID":1906},"Fajans SS, Bell GI, Polonsky KS: Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N Engl J Med 2001,345(13):971–80. Epub 2001\u002F09\u002F29 10.1056\u002FNEJMra002168\nNyunt O, Wu JY, McGown IN, Harris M, Huynh T, Leong GM, et al.: Investigating maturity onset diabetes of the young. The Clinical biochemist Reviews \u002FAustralian Association of Clinical Biochemists 2009,30(2):67–74. Epub 2009\u002F07\u002F01\nShields BM, Hicks S, Shepherd MH, Colclough K, Hattersley AT, Ellard S: Maturity-onset diabetes of the young (MODY): how many cases are we missing? Diabetologia 2010,53(12):2504–8. Epub 2010\u002F05\u002F26 10.1007\u002Fs00125-010-1799-4\nThanabalasingham G, Owen KR: Diagnosis and management of maturity onset diabetes of the young (MODY). BMJ 2011, 343: d6044. Epub 2011\u002F10\u002F21 10.1136\u002Fbmj.d6044\nVelho G, Vaxillaire M, Boccio V, Charpentier G, Froguel P: Diabetes complications in NIDDM kindreds linked to the MODY3 locus on chromosome 12q. Diabetes Care 1996,19(9):915–9. Epub 1996\u002F09\u002F01 10.2337\u002Fdiacare.19.9.915\nMcDonald TJ, Colclough K, Brown R, Shields B, Shepherd M, Bingley P, et al.: Islet autoantibodies can discriminate maturity-onset diabetes of the young (MODY) from Type 1 diabetes. Diabetic medicine : a journal of the British Diabetic Association 2011,28(9):1028–33. Epub 2011\u002F03\u002F15 10.1111\u002Fj.1464-5491.2011.03287.x\nGaller A, Stange T, Muller G, Nake A, Vogel C, Kapellen T, et al.: Incidence of childhood diabetes in children aged less than 15 years and its clinical and metabolic characteristics at the time of diagnosis: data from the Childhood Diabetes Registry of Saxony, Germany. Hormone research in paediatrics 2010,74(4):285–91. Epub 2010\u002F06\u002F03 10.1159\u002F000303141\nEhtisham S, Hattersley AT, Dunger DB, Barrett TG: British Society for Paediatric E, Diabetes Clinical Trials G. First UK survey of paediatric type 2 diabetes and MODY. Arch Dis Child 2004,89(6):526–9. 10.1136\u002Fadc.2003.027821\nAwa WL, Schober E, Wiegand S, Herwig J, Meissner T, Schmidt F, et al.: Reclassification of diabetes type in pediatric patients initially classified as type 2 diabetes mellitus: 15 years follow-up using routine data from the German\u002FAustrian DPV database. Diabetes research and clinical practice 2011,94(3):463–7. Epub 2011\u002F10\u002F01 10.1016\u002Fj.diabres.2011.09.011\nHotu S, Carter B, Watson PD, Cutfield WS, Cundy T: Increasing prevalence of type 2 diabetes in adolescents. Journal of paediatrics and child health 2004,40(4):201–4. Epub 2004\u002F03\u002F11 10.1111\u002Fj.1440-1754.2004.00337.x\nKropff J, Selwood MP, McCarthy MI, Farmer AJ, Owen KR: Prevalence of monogenic diabetes in young adults: a community-based, cross-sectional study in Oxfordshire UK. Diabetologia 2011,54(5):1261–3. Epub 2011\u002F02\u002F26 10.1007\u002Fs00125-011-2090-z",{"VOID":1908},"10.1186\u002F2251-6581-12-46","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1186\u002F2251-6581-12-46",[1911,1935,1948,1972,1985,1998,2011],{"id":1912,"sortIndex":32,"researcher":28,"roles":1913,"affiliations":1914,"properties":1932,"displayName":1934,"givenName":28,"familyName":28},"a09fe1d0-3cac-4c55-bb71-3bc926c92bac",[978],[1915,1923],{"id":1916,"sortIndex":32,"affiliation":1917,"properties":28},"60023923-e14c-49fc-a6c1-794a9f121b0b",{"id":1916,"createTime":28,"updateTime":28,"relativeEntities":1918,"slug":28,"properties":1919,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1922,"statistic":28},[],{"title":1920},{"VI":1921},"Department of Women’s and Children’s Health, University of Otago, Dunedin, New Zealand",[],{"id":1924,"sortIndex":40,"affiliation":1925,"properties":1931},"112a26fd-490e-4270-abfd-84fc331bd807",{"id":1924,"createTime":28,"updateTime":28,"relativeEntities":1926,"slug":28,"properties":1927,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1930,"statistic":28},[],{"title":1928},{"VI":1929},"Edgar National Centre for Diabetes and Obesity Research, University of Otago, Dunedin, New Zealand",[],{},{"title":1933},{"VI":1934},"Benjamin J 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a dipeptidyl peptidase-4 (DPP-4) inhibitor, is wildly used to treat type 2 diabetes mellitus (T2DM) with mono- or combination-therapy. We review two previously published open-label studies to extract insights on the long-term efficacy and safety of vildagliptin. Two studies were conducted in Japan to assess the efficacy and safety of vildagliptin as an add-on to other oral antidiabetes drugs (OADs) for 52 weeks. These studies were performed under the similar protocol in Japanese patients with T2DM who were inadequately controlled with OAD monotherapy [excluding other dipeptidyl peptidase-4 (DPP-4) inhibitors]. Addition of vildagliptin (50 mg twice daily) to other OAD monotherapy [sulfonylurea (SU), metformin, thiazolidinedione, alpha-glucosidase inhibitor and glinide] reduced glycated hemoglobin (HbA1c) levels by −0.64 %,−0.75 %,−0.92 %,−0.94 % and − 0.64 %, respectively, over 52 weeks of treatment. Overall, the incidence of hypoglycemia was low and was slightly higher in the add-on to SU treatment group compared with the other groups. The incidences of adverse events were comparable among the treatment groups, and vildagliptin was well-tolerated as add-on therapy to other OADs. The evidence from the two studies indicates that vildagliptin as an add-on therapy to other OADs is a clinically reasonable option for Japanese patients with T2DM who respond inadequately to other OAD monotherapy.",{"EN":2090},"Effects of vildagliptin as add-on treatment in patients with type 2 diabetes mellitus: insights from long-term clinical studies in Japan",{"VOID":2092},"[]",{"VOID":2094},"Treatment Guide for Diabetes 2012–2013. the Japan Diabetes Society. Bunkodo Co. Ltd. 2013.\nInzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, et al. Management of hyperglycemia in type 2 diabetes, 2015: a patient centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2015;38:140–9.\nOishi M, Yamazaki K, Okuguchi F, Sugimoto H, Kanatsuka A, Kashiwagi A. Japan Diabetes Clinical Data Management Study Group. Changes in oral antidiabetic prescriptions and improved glycemic control during the years 2002–2011 in Japan (JDDM32). J Diabetes Invest. 2014;5:581–7.\nJapan Diabetes Clinical Data Management Study Group (JDDM). Available at: http:\u002F\u002Fjddm.jp\u002Fdata\u002Findex.html (Last accessed, 2nd Feb, 2016).\nNamba M, Katsuno T, Kusunoki Y, Matsuo T, Miuchi M, Miyagawa J. New strategy for the treatment of type 2 diabetes mellitus with incretin-based therapy. Clin Exp Nephrol. 2013;17:10–5.\nDrucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet. 2006;368:1696–705.\nKim W, Egan JM. The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev. 2008;60:470–512.\nKrentz AJ, Patel MB, Bailey CJ. New drugs for type 2 diabetes mellitus: what is their place in therapy? Drugs. 2008;68:2131–62.\nPi-Sunyer FX, Schweizer A, Mills D, Dejager S. Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type 2 diabetes. Diabetes Res Clin Pract. 2007;76:132–8.\nBosi E, Camisasca RP, Collober C, Rochotte E, Garber AJ. Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin. Diabetes Care. 2007;30:890–5.\nGarber AJ, Foley JE, Banerji MA, Ebeling P, Gudbjörnsdottir S, Camisasca RP, et al. Effects of vildagliptin on glucose control in patients with type 2 diabetes inadequately controlled with a sulphonylurea. Diabetes Obes Metab. 2008;10:1047–56.\nGarber AJ, Schweizer A, Baron MA, Rochotte E, Dejager S. Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: a randomized, placebo-controlled study. Diabetes Obes Metab. 2007;9:166–74.\nKothny W, Foley J, Kozlovski P, Shao Q, Gallwitz B, Lukashevich V. Improved glycaemic control with vildagliptin added to insulin, with or without metformin, in patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2013;15:252–7.\nKim YG, Hahn S, Oh TJ, Kwak SH, Park KS, Cho YM. Differences in the glucose-lowering efficacy of dipeptidyl peptidase-4 inhibitors between Asians and non-Asians: a systematic review and meta-analysis. Diabetologia. 2013;56:696–708.\nMinistry of Health, Labour and Welfare. Guideline for clinical evaluation of oral hypoglycemic agents. Issued on 9th July 2011. Available at: http:\u002F\u002Fwww.pmda.go.jp\u002Ffiles\u002F000153859.pdf (Last accessed, 2nd Feb 2016).\nKikuchi M, Utsunomiya K, Moriya T, Terao S, Kitawaki T, Mimori N, et al. Long-term evaluation of vildagliptin in patients with type 2 diabetes; mono or combination with sulfonylurea therapy for 52 weeks. J New Rem Clin. 2010;59:137–54 (in Japanese).\nOdawara M, Suzuki M, Hamada I, Iguchi S. Clinical evaluation of combination therapy with vildagliptin in patients with type 2 diabetes; safety of add-on to metformin, thiazolidine, α-GI or glinide for 52 weeks. J New Rem Clin. 2012;61:2593–611 (in Japanese).\nMadsbad S, Krarup T, Deacon CF, Holst JJ. Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trials. Curr Opin Clin Nutr Metab Care. 2008;11:491–9.\nSignorovitch JE, Wu EQ, Swallow E, Kantor E, Fan L, Gruenberger JB. Comparative efficacy of vildagliptin and sitagliptin in Japanese patients with type 2 diabetes mellitus: a matching-adjusted indirect comparison of randomized trials. Clin Drug Investig. 2011;31:665–74.\nDavis JA, Singh S, Sethi S, Roy S, Mittra S, Rayasam G, et al. Nature of action of Sitagliptin, the dipeptidyl peptidase-IV inhibitor in diabetic animals. Indian J Pharmacol. 2010;42:229–33.\nAhrén B, Schweizer A, Dejager S, Villhauer EB, Dunning BE, Foley JE. Mechanisms of action of the dipeptidyl peptidase-4 inhibitor vildagliptin in humans. Diabetes Obes Metab. 2011;13:775–83.\nSakamoto M, Nishimura R, Irako T, Tsujino D, Ando K, Utsunomiya K. Comparison of vildagliptin twice daily vs. sitagliptin once daily using continuous glucose monitoring (CGM): crossover pilot study (J-VICTORIA study). Cardiovasc Diabetol. 2012;11:92.\nEsposito K, Chiodini P, Maiorino MI, Capuano A, Cozzolino D, Petrizzo M, et al. A nomogram to estimate the HbA1c response to different DPP-4 inhibitors in type 2 diabetes: a systematic review and meta-analysis of 98 trials with 24 163 patients. BMJ Open. 2015;5, e005892.\nPhung OJ, Scholle JM, Talwar M, Coleman CI. Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes. JAMA. 2010;303:1410–8.\nKubota A, Maeda H, Kanamori A, Atoba K, Jin Y, Minagawa F, et al. Efficacy and safety of sitagliptin monotherapy and combination therapy in Japanese type 2 diabetes patients. J Diabetes Invest. 2012;3:503–9.\nFoley JE, Jordan J. Weight neutrality associated with the DPP-4 inhibitor, vildagliptin: mechanistic basis and clinical experience. Vasc Health Risk Manag. 2010;6:541–8.\nHirose T, Suzuki M, Tsumiyama I. Efficacy and Safety of Vildagliptin as an Add-on to Insulin with or without Metformin in Japanese Patients with Type 2 Diabetes Mellitus: A 12-week, Double-Blind, Randomized Study. Diabetes Ther. 2015;6:559–71.\nSavarese G, Perrone-Filardi P, D’Amore C, Vitale C, Trimarco B, Pani L, et al. Cardiovascular effects of dipeptidyl peptidase-4 inhibitors in diabetic patients: A meta-analysis. Int J Cardiol. 2015;181:239–44.\nAbbas AS, Dehbi HM, Ray KK. Cardiovascular and non-cardiovascular safety of dipeptidyl peptidase-4 inhibition: a meta-analysis of randomized controlled cardiovascular outcome trials. Diabetes Obes Metab. 2016;18:295–9.",{"VOID":2096},"10.1186\u002Fs40200-016-0240-z","2024-05-13T09:56:57.998+00:00","http:\u002F\u002Flink.springer.com\u002F10.1186\u002Fs40200-016-0240-z",[2100,2115],{"id":2101,"sortIndex":32,"researcher":28,"roles":2102,"affiliations":2103,"properties":2112,"displayName":2114,"givenName":28,"familyName":28},"173452cd-9d8f-4abc-8ad5-475063a8bda3",[978],[2104],{"id":2105,"sortIndex":32,"affiliation":2106,"properties":28},"695ae677-ad7d-47a3-99f9-2bd682a360ee",{"id":2105,"createTime":28,"updateTime":28,"relativeEntities":2107,"slug":28,"properties":2108,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2111,"statistic":28},[],{"title":2109},{"VI":2110},"The Department of Diabetology, Endocrinology, Metabolism and Rheumatology, Tokyo Medical University, Shinjuku-ku, Japan",[],{"title":2113},{"VI":2114},"Masato 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studies have reported that insulin resistance impairs the antioxidant defense system and causes male infertility. Moringa oleifera is a medicinal plant that has been employed for the medicament of many disorders. It controls the levels of glucose and manages male sexual disorders. However, its extracts can reverse insulin resistance-linked metabolic alterations remains unknown. Therefore, the current study investigated the potential of the aqueous leaves extract from Moringa oleifera to reverse insulin resistance and testicular disorders in rats. Rats were fed either a chow (as a control group) or a high fructose diet (HFD, to persuade a state of insulin resistance), in addition to a group of rats fed HFD and treated with Moringa (300 mg\u002Fkg) for 4 weeks. Moringa reversed hepatic insulin insensitivity and this was linked to up-regulation of genes involved in insulin receptors and glucose uptake in the liver. These results were associated with amended the insulin level in serum and standardization of insulin sensitivity. In addition, it improved the serum testosterone level and the gene expression of the testicular steridogenic acute regulatory protein (StAR) and 3β-hydroxysteroid dehydrogenase (3β-HSD). Taken together, our findings demonstrate that Moringa reversed HFD diet-induced insulin resistance and improved the testicular function.",{"EN":2196},"Molecular effects of Moringa leaf extract on insulin resistance and reproductive function in hyperinsulinemic male rats",{"VOID":2198},"Zagrodzki P, Joniec A, Gawlik M, Gawlik M, Krośniak M, Fołta M, et al. High fructose model of oxidative stress and metabolic disturbances in rats. part I. antioxidant status of rats’ tissues. Bull Vet Inst Pulawy. 2007;51:407–12.\nZhang D, Jiao R, Kong L. High Dietary Fructose: Direct or Indirect Dangerous Factors Disturbing Tissue and Organ Functions. Nutrients. 2017;9:335.\nAmerican Diabetes Association. Consensus Development Conference on Insulin Resistance. Diabetes Care. 1997;21:310–4.\nHall JE. Guyton and Hall textbook of medical physiology e-Book. Amsterdam: Elsevier Health Sciences; 2015.\nYaribeygi H, Farrokhi FR, Butler AE, Sahebkar A. Insulin resistance: Review of the underlying molecular mechanisms. J Cell Physiol. 2019;234:8152–61.\nOlatunbosun ST, Schade D. Insulin resistance. eMedicine. Accessed February 26, 2018.\nOmbelet W, Cooke I, Dyer S, Serour G, Devroey P. Infertility and the provision of infertility medical services in developing countries. Hum Reprod Update. 2008;14:605–21.\nInhorn MC, Patrizio P. Infertility around the globe: New thinking on gender, reproductive technologies and global movements in the 21st century. Hum Reprod Update. 2015;21:411–26.\nHassan MA, Killick SR. Negative lifestyle is associated with a significant reduction in fecundity. Fertil Steril. 2004;81:384–92.\nChavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Diet and lifestyle in the prevention of ovulatory disorder infertility. Obstet Gynecol. 2007;110:1050–8.\nChan O, Chan S, Inouye K, Vranic M, Matthews SG. Molecular regulation of the hypothalamo-pituitary-adrenal axis in streptozotocin-induced diabetes: effects of insulin treatment. Endocrinol. 2001;142:4872–9.\nShi G-J, Zheng J, Wu J, et al. Protective effects of Lycium barbarum polysaccharide on male sexual dysfunction and fertility impairments by activating hypothalamic pituitary gonadal axis in streptozotocin-induced type-1 diabetic malemice. Endocr J. 2017;64:907–22.\nPark K, Gross M, Lee D, Holvoet P, Himes JH, Shikany JM, et al. Oxidative Stress and Insulin Resistance The Coronary Artery Risk Development in Young Adults study. Diabetes Care. 2009;32:1302–7.\nDoshi SB, Khullar K, Sharma RK, Agarwal A. Role of reactive nitrogen species in male infertility. Reprod Biol Endocrinol. 2012;10:1–11.\nCaceres A, Saravia A, Rizzo S, Zabala L, Leon ED, Nave F. Pharmacology properties of Moringa oleifera. 2: Screening for antispasmodic, antiinflammatory and diuretic activity. J Ethnopharmacol. 1992;36:233–7.\nUdupa SL, Udupa AL, Kulkarni DR. Studies on anti-inflammatory and wound healing properties of Moringa oleifera and Aegle marmelos. Fitoterapia. 1994;65:119–23.\nPal SK, Mukherjee PK, Saha BP. Studies on the antiulcer activity of Moringa oleifera leaf extract on gastric ulcer models in rats. Phytother Res. 1995;9:463–5.\nPrabsattroo T, Wattanathorn J, Iamsa-ard S, Muchimapura S, Thukhammee W. Moringa Oleifera Leaves Extract Attenuates Male Sexual Dysfunction. Am J Neurosci. 2012;3:17–24.\nRajasekar P, Kaviarasan S, Anuradha CV. L-carnitine administration prevents oxidative stress in high fructose-fed insulin resistant rats. Diabetol Croat. 2005;34:21–8.\nBerkovich L, Earon G, Ron I, Rimmon A, Vexler A, Lev-Ari S. Moringa Oleifera aqueous leaf extract down-regulates nuclear factor-kappaB and increases cytotoxic effect of chemotherapy in pancreatic cancer cells. BMC Complement Altern Med. 2013;13:212.\nBrieskorn CZ, Klinger H, Polonius W. Triterpenes and sterols in leaves of Salvia trioloba and Pyrus malus. Arch Pharm. 1961;294:389–91.\nGeissmann TA. The Chemistry of Flavonoids Compounds. New York: Pergamon Press; 1962.\nWoo WS, Chi HJ, Yun HS, Hye S. Alkaloid screening of some Saudi Arabian plants. Kor J Pharmacog. 1977;8:109–13.\nTreare GE, Evans WC. Pharmacognosy. 17th ed. London: Bahiv Tinal; 1985.\nKokate CK, Purohit AP, Gokhale SB. Carbohydrate and derived products, drugs containing glycosides, drugs containing tannins, lipids and protein alkaloids. Textbook of Pharmacognosy. 2001.\nAhmad B, Naeem AK, Ghufran A, Innamudin I. Pharmacological Investigation of Cassia sophera, Linn. Var. purpura, Roxb. Med J Islam World Academy Sci. 2005;15:105–9.\nNikhal SB, Dambe PA, Ghongade DB, Goupale DC. Hydroalcoholic extraction of Mangifera indica (leaves) by Soxhletion. Inter J Pharm Sci. 2010;2:30–2.\nJaiswal D, Rai PK, Mehta S, Chatterji S, Shukla S, Rai DK, et al. Role of Moringa oleifera in regulation of diabetes-induced oxidative stress. Asian Pac J Trop Med. 2013;2013:426–32.\nSharp P. Interference in glucose oxidase-peroxidase blood glucose methods. Clin Chem Acta. 1972;40:115–20.\nDhahir FJ, Cook DB, Self CH. Amplified enzyme-linked immunoassay of human pro-insulin in serum. Clin Chem. 1992;38:227–32.\nPickavance LC, Tadayyon M, Widdowson PS, Buckingham RE, Wilding JP. Therapeutic index for rosiglitazone in dietary obese rats. Separation of efficacy and haemodilution. Br J Pharmacol. 1999;128:1570–6.\nRosner W, Auchus RJ, Azzis R. Position statement: utility, limitations, and pitfalls in measuring testosterone: An Endocrine Society Positions Statement. J Clin Endocrinol Metab. 2007;92:404–13.\nClarke JJ, Cummins JT. Pulsatility of reproductive hormones: physiological basis and clinical implications. Baillieres Clin Endocrinol Metab. 1987;1:1–21.\nOhkawa H, Ohishi W, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351–8.\nNishikimi M, Roa NA. Yogi k. Measurement of superoxide dismutase. Biochem Biophys Res Commun. 1972;46:849–54.\nAebi H. Catalase in vitro. In: Packer L, editor. Methods in Enzymology. Oxygen Radicals in Biological systems. Orlando, FL: Academic Press; 1984. p. 121–6.\nRizk SM, Zaki HF, Mina MA. Propolis attenuates doxorubicin-induced testicular toxicity in rats. Food Chem Toxicol. 2014;67:176–86.\nLimaye PV, Raghuram N, Sivakami S. Oxidative stress and gene expression of antioxidant enzymes in the renal cortex of streptozotocin-induced diabetic rats. Mol Cell Biochem. 2003;243:147–52.\nAnwar F, Latif S, Ashraf M, Gilani AH. Moringa oleifera: a food plant with multiple medicinal uses. Phytother Res. 2007;21:17–25.\nZade VS, Dabhadkar DK, Thakare VG, Pare SR. Effect of Aqueous Extract of Moringa oleifera Seed on Sexual Activity of Male Albino Rats. Biological Forum – An International Journal. 2013;5:129–40.\nBailey SA, Zidell RH, Perry RW. Relationships Between Organ Weight and Body\u002FBrain Weight in the Rat: What Is the Best Analytical Endpoint? Toxicol Pathol. 2004;32:448–66.\nKumamoto R, Uto H, Oda K, Ibusuki R, Tanoue S, Arima S, et al. Dietary fructose enhances the incidence of precancerous hepatocytes induced by administration of diethylnitrosamine in rat. Eur J Med Res. 2013;18:54.\nSchwarz J, Noworolski SM, Wen MJ, Dyachenko A, Prior JL, Weinberg ME, et al. Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat. J Clin Endocrinol Metab. 2015;100:2434–42.\nAbd El-Wahab HMF, Mohamed MA, El Sayed HH, Bauomy AE. Modulatory effects of rice bran and its oil on lipid metabolism in insulin resistance rats. J Food Biochem. 2017;41:e12318.\nNieto-Vazquez I, Fernández-Veledo S, de Alvaro C, Lorenzo M. Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle. Diabetes. 2008;57:3211–21.\nMahfouz MH, Ghanem HM, Mohamed MA. Modulation of insulin receptor substrate-1 and some inflammatory variables in hyperinsulinemic rats treated with cinnamon extract. Am J Biochem Biotech. 2010;6:11–8.\nHu Y, Hou Z, Yi R, Wang Z, Sun P, Li G, et al. Tartary buckwheat flavonoids ameliorate high fructose-induced insulin resistance and oxidative stress associated with the insulin signaling and Nrf2\u002FHO-1 pathways in mice. Food Funct. 2017;8:2803–16.\nLópez M, Rios-Silva M, Huerta M, Cárdenas Y, Bricio-Barrios JA, Diaz-Reval MI, et al. Effects of Moringa oleifera leaf powder on metabolic syndrome induced in male Wistar rats: a preliminary study. J Inter Med Res. 2018;46:3327–36.\nMunir KM, Chandrasekaran S, Gao F, Quon MJ. Mechanisms for food polyphenols to ameliorate insulin resistance and endothelial dysfunction: therapeutic implications for diabetes and its cardiovascular complications. Am J Physiol Endocrinol Metab. 2013;305:E679–86.\nNandhini AT, Anuradha CV. Taurine modulates kallikrein activity and glucose metabolism in insulin-resistant rats. Amino Acids. 2002;22:27–38.\nJaiswal D, Rai PK, Kumar A, Mehta S, Watal G. Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats. J Ethnopharmacol. 2009;123:392–6.\nKumari DJ. Hypoglycemic effect of Moringa oleifera and Azadirachta indica in type-2 diabetes. Bioscan. 2010;5:211–4.\nYassa HD, Tohamy AF. Extract of Moringa oleifera leaves ameliorates streptozotocin-induced diabetes mellitus in adult rats. Acta Histochem. 2014;116:844–54.\nTende JA, Ezekiel I, Dikko AAU, Goji ADT. Effect of Ethanolic Leaves Extract of Moringa oleifera on Blood Glucose Levels of Streptozocin-Induced Diabetics and Normoglycemic Wistar Rats. Br J Pharmacol Toxicol. 2011;2:1–4.\nAbdel-Kawi SH, Hassanin KM, Hashem KS. The effect of high dietary fructose on the kidney of adult albino rats and the role of curcumin supplementation: A biochemical and histological study. Beni-Suef Univ J Basic App Sci. 2016;5:52–60.\nAkunna GG, Ogunmodede OS, Saalu CL, Ogunlade B, Bello AJ, Salawu EO. Ameliorative Effect of Moringa oleifera (drumstick) Leaf Extracts on Chromium-Induced Testicular Toxicity in Rat Testes. World J Life Sci and Med Res. 2012;2:20.\nDiemer T, Allen JA, Hales KH, Hales DB. Reactive oxygen disrupts mitochondria in MA-10 tumor leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis. Endocrinology. 2003;144:2882–91.\nChristenson LK, Strauss I, Jerome F. Steroidogenic acute regulatory protein; an update on its regulation and mechanism of action. Arch Med Res. 2001;32:576–86.\nStocco DM. StAR protein and the regulation of steroid hormone biosynthesis. Annu Rev Physiol. 2001;63:193–213.\nRasmussen MK, Ekstrand B, Zamaratskaia G. Regulation of 3β-Hydroxysteroid dehydrogenase\u002F Δ5-Δ4 isomerase: A Review. Int J Mol Sci. 2013;14:17926–42.\nAllen C, McLachlan R. Testosterone deficiency in men: diagnosis and management. Aust Family Phys. 2003;32:422–9.\nSengupta P. Environmental and occupational exposure of metals and their role in male reproductive functions. Drug Chem Toxicol. 2013;36:353–68.\nKim ST, Moley KH. Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expression. Reproduction. 2008;136:313–22.\nPriyadarshani N, Varma MC. Effect of Moringa oleifera leaf powder on sperm count, histology of testis and epididymis of hyperglycaemic mice Mus musculus. Am Inter J Res For Appl Nat Sci. 2014;7:7–13.\nPasquali R, Casimirri F, Cantobelli S, Melchionda N, Morselli Labate AM, Fabbri R, et al. Effect of obesity and body fat distribution on sex hormones and insulin in men. Metabolism. 1991;40:101–4.\nShukla VN, Khanuja SP. Chemical, Pharmacological and botanical studies on Pedalium murex. J Med Aromatic Plant Sci. 2004;26:64–96.\nPadashetty SA, Mishra SH. Aphrodisiac studies of Tricholepis glaberrima with supportive action from antioxidant enzyme. Pharm Biol. 2007;45:580–6.",{"VOID":2200},"10.1007\u002Fs40200-019-00454-7","http:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs40200-019-00454-7",[2203,2218,2242],{"id":2204,"sortIndex":32,"researcher":28,"roles":2205,"affiliations":2206,"properties":2215,"displayName":2217,"givenName":28,"familyName":28},"a1e5df93-5ac0-4969-8753-650f5d249ea1",[978],[2207],{"id":2208,"sortIndex":32,"affiliation":2209,"properties":28},"7f995210-cdb7-4264-961e-6b9b2019ed5d",{"id":2208,"createTime":28,"updateTime":28,"relativeEntities":2210,"slug":28,"properties":2211,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2214,"statistic":28},[],{"title":2212},{"VI":2213},"Biochemistry Division, Chemistry Department, Faculty of Science, Al-Azhar University (Girls Branch), Cairo, Egypt",[],{"title":2216},{"VI":2217},"Mona A. 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The solute carrier family, 5 member 2 (SLC5A2) gene is a member of sodium\u002Fglucose transporter family which can reduce heart and kidney problems. The current study aims to look into any association between rs11646054 variant in SLC5A2 gene and the anti-diabetic efficacy and safety of empagliflozin. 14 T2DM who failed to respond to previous treatments, empagliflozin 10 mg was added for 6 months. Genotyping of the rs11646054 variant of SLC5A2 gene was performed by polymerase chain reaction (PCR) followed by Sanger sequencing. Although hemoglobin A1c (HbA1c) and low-density lipoprotein (LDL) were not significantly different, but the mean fasting blood sugar (FBS), 2-h post prandial (2hpp), albumin-to-creatinine ratio (ACR), and total cholesterol (TC) were significantly decreased after 6 months empagliflozin treatment. There was a significant difference in the mean final reductions in FBS level among genotypes. It's important to mention that those who were GG homozygotes had a tendency to have more decrements. The study results indicate that effects of variation in SLC5A2 (rs11646054) on the clinical efficacy of empagliflozin were negligible.",{"EN":2319},"Pilot study in pharmacogenomic management of empagliflozin in type 2 diabetes mellitus patients",{"VOID":2321},"Atlas ID. 7th edn. Brussels, Belgium: International Diabetes Federation; 2015. International Diabetes Federation.\nWorld Health Organization (WHO). Global report on diabetes. http:\u002F\u002Fwww.whoint\u002Fdiabetes\u002Fglobal-report\u002Fen\u002F\nRodriguez-Gutierrez R, Gionfriddo MR, Ospina NS, Maraka S, Tamhane S, Montori VM, et al. Shared decision making in endocrinology: present and future directions. Lancet Diabetes Endocrinol. 2016;4(8):706–16.\nHenry R, Murray A, Marmolejo M, Hennicken D, Ptaszynska A, List J. Dapagliflozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trial. Int J Clin Pract. 2012;66(5):446–56.\nDavies MJ, D’Alessio DA, Fradkin J, Kernan WN, Mathieu C, Mingrone G, et al. Management of hyperglycemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2018;41(12):2669–701.\nHolman RR, Paul SK, Bethel MA, Matthews DR, Neil HAW. 10-year follow-up of intensive glucose control in type 2 diabetes. N Eng J Med. 2008;359(15):1577–89.\nVijan S, Sussman JB, Yudkin JS, Hayward RA. Effect of patients’ risks and preferences on health gains with plasma glucose level lowering in type 2 diabetes mellitus. JAMA Intern Med. 2014;174(8):1227–34.\nWright EM, Loo DD, Hirayama BA. Biology of human sodium glucose transporters. Physiol Rev. 2011;91(2):733–94.\nDeFronzo R, Davidson J, Del Prato S. The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia. Diabetes Obes Metab. 2012;14(1):5–14.\nRieg T, Vallon V. Development of SGLT1 and SGLT2 inhibitors. Diabetologia. 2018;61(10):2079–86.\nSanter R, Calado J. Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target. Clin J Am Soc Nephrol. 2010;5(1):133–41.\nTönjes A, Kovacs P. SGLT2: a potential target for the pharmacogenetics of Type 2 diabetes? Pharmacogenomics. 2013;14(7):825–33.\nChandra R. The role of pharmacogenomics in precision medicine. Contin Educ. 2017:0.\nCarrasco-Ramiro F, Peiró-Pastor R, Aguado B. Human genomics projects and precision medicine. Gene Ther. 2017;24(9):551–61.\nMannino GC, Sesti G. Individualized therapy for type 2 diabetes. Mol Diagn Ther. 2012;16(5):285–302.\nStumvoll M, Goldstein BJ, Van Haeften TW. Type 2 diabetes: principles of pathogenesis and therapy. Lancet. 2005;365(9467):1333–46.\nAmerican Diabetes Association (ADA). 2 Classification and diagnosis of diabetes: standards of medical care in diabetes—2019. Diabetes Care. 2019;42(Supplement 1):S13–28.\nAmerican Diabetes Association (ADA). Standards of medical care in diabetes—2015 abridged for primary care providers. Clin Diabetes. 2015;33(2):97.\nVasquez-Rios G, Nadkarni GN. SGLT2 Inhibitors: emerging roles in the protection against cardiovascular and kidney disease among diabetic patients. Int J Nephrol Renovasc Dis. 2020;13:281.\nVerma S, McMurray JJ. SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review. Diabetologia. 2018;61(10):2108–17.\nSeferović PM, Petrie MC, Filippatos GS, Anker SD, Rosano G, Bauersachs J, et al. Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2018;20(5):853–72.\nMyburgh R, Hochfeld WE, Dodgen TM, Ker J, Pepper MS. Cardiovascular pharmacogenetics. Pharmacol Ther. 2012;133(3):280–90.\nBecker ML, Pearson ER, Tkáč I. Pharmacogenetics of oral antidiabetic drugs. Int J Endocrinol. 2013;2013.\nZimdahl H, Haupt A, Brendel M, Bour L, Machicao F, Salsali A, et al. Influence of common polymorphisms in the SLC5A2 gene on metabolic traits in subjects at increased risk of diabetes and on response to empagliflozin treatment in patients with diabetes. Pharmacogenet Genomics. 2017;27(4):135–42.\nHeise T, Seewaldt-Becker E, Macha S, Hantel S, Pinnetti S, Seman L, et al. Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeks’ treatment with empagliflozin once daily in patients with type 2 diabetes. 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