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other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. 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In China, the specific clinical use is angina pectoris, hyperlipidemia, and acute ischemic stroke. The current review covers its traditional uses, chemical constituents, pharmacological activities, pharmacokinetics, clinical applications, and potential herb‐drug interactions based on information obtained in both the English and Chinese literature. Although numerous clinical trials have demonstrated that certain Danshen products in China are effective and safe for the treatment of cardiovascular diseases, most of these lack sufficient quality. Therefore, large randomized clinical trials and further scientific research to determine its mechanism of actions will be necessary to ensure the safety, effectiveness, and better understanding of its action\u003C\u002Fjats:italic>.\u003C\u002Fjats:p>",{"EN":811},"Danshen: An Overview of Its Chemistry, Pharmacology, Pharmacokinetics, and Clinical Use",{"VOID":813},"16291709",{"VOID":815},"10.1177\u002F0091270005282630","PUBLICATION","Auto Verify",[102],"https:\u002F\u002Faccp1.onlinelibrary.wiley.com\u002Fdoi\u002F10.1177\u002F0091270005282630",[821,840,857],{"id":822,"sortIndex":114,"researcher":26,"roles":823,"affiliations":824,"properties":835},"2868607d-56dc-4733-9fc6-dd62385fcce9",[],[825],{"id":826,"sortIndex":36,"affiliation":827,"properties":26},"aeee4e50-ab23-4c6d-ac24-b52f0deb4f0d",{"id":828,"createTime":829,"updateTime":829,"relativeEntities":830,"slug":831,"properties":832,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"3b4a19d7-b117-4022-882c-21ed963f50c0","2024-09-19T02:43:19.952+00:00",[],"School-of-Pharmacy-and-Drug-Development-Centre-Faculty-of-Medicine-The-Chinese-University-of-Hong-Kong-Shatin-New-Territories-Hong-Kong-SAR-PRC",{"title":833},{"EN":834},"School of Pharmacy and Drug Development Centre, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, SAR, PRC",{"openalex":836,"title":838},{"VOID":837},"A5103420258",{"EN":839},"Moses S. 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JY., 1998, Clinical observation of the treatment of hyperlipemia with Danshen composite, Tianjin Zhongyi, 15, 24",{},{"id":26,"text":925,"url":26,"identifiers":926},"Wu XY, 2000, Clinical observation of the treatment of 60 hyperlipaemia with Fufang Danshen Dripping Pill, Hebei Zhongyi, 22, 671",{},{"id":26,"text":928,"url":26,"identifiers":929},"Ma WY, 2001, Effect of Danshen composite on hyperlipaemia and blood rheology, Jiefangjun Yaoxue Xuebao, 17, 47",{},{"id":26,"text":931,"url":26,"identifiers":932},"Cui SK, 2003, Clinical effect of Fufang Danshen Dripping Pill on hyperlipemia, Xiandai Zhongxiyi Jiehe Zazhi, 11, 1029",{},{"id":26,"text":934,"url":26,"identifiers":935},"Mao JM, 2001, Clinical observation of Danshen composite on cerebral infarction, Jiefangjun Yaoxue Xuebao, 17, 49",{},{"id":26,"text":937,"url":26,"identifiers":938},"Guo ZX, 2003, Clinical investigation of composite Danshen Dripping Pill for the treatment of angina pectoris, Zhongguo Tianran Yaowu, 1, 124",{},{"id":26,"text":940,"url":26,"identifiers":941},"Liu XQ, 2001, Research advance of Fufang Danshen dosage forms, Shizhen Guoyi Guoyao, 12, 474",{},{"id":26,"text":943,"url":26,"identifiers":944},"Hu XR, 2003, An investigation of Danshen root: pharmacology study, clinical application and preparation, Zhongguo Xinyiyao, 2, 54",{},{"id":26,"text":946,"url":26,"identifiers":947},"Ge YR, 2002, Review of research on pharmacopoeia prescription preparation of compound salvia, Zhong Cheng Yao, 24, 872",{},{"id":26,"text":949,"url":26,"identifiers":950},"Hu RF, 2002, Study on tanshinone rapid soluble tablet, Zhongguo Yaoshi, 5, 461",{},{"id":26,"text":952,"url":26,"identifiers":953},"Chu MQ, 2002, Study on the preparation of tanshinone preliposomes by spray drying method, Zhongguo Yaoxue Zazhi, 37, 32",{},{"id":26,"text":955,"url":26,"identifiers":956},"Chu MQ, 2001, Study on solid dispersion of tanshinone, Huadong Ligong Daxue Xuebao, 27, 191",{},{"id":26,"text":958,"url":26,"identifiers":959},"The Pharmacopoeia Commission of PRC., 2005, Pharmacopoeia of the People's Republic of China Version 2005",{},{"id":26,"text":961,"url":26,"identifiers":962},"Tianjin Talisco Pharmaceutical Group Co. Ltd.Approval of Compound Danshen Dripping Pill (DSP) by FDA through pre‐IND for clinical trials.Proceedings of Forum of Internationalized Chinese Materia Medica.1998:18–30.",{},{"id":26,"text":964,"url":26,"identifiers":965},"Kong DY., 1989, Chemical constituents of Salvia miltiorrhiza (Danshen), Zhongguo Yiyao Gongye Zazhi, 20, 279",{},{"id":26,"text":967,"url":26,"identifiers":968},"Zheng GH, 1989, Research on chemical constituents of Danshen, Zhongguo Yaoxue Zazhi, 24, 6",{},{"id":26,"text":970,"url":26,"identifiers":971},"Cai DG., 1991, Advances in the study of chemical constituents of Danshen, Zhongguo Zhongyao Zazhi, 16, 376",{},{"id":26,"text":973,"url":26,"identifiers":974},"Li LN., 1997, Water soluble active components of Salvia miltiorrhiza and related plants, Zhongguo Yaoxue, 6, 57",{},{"id":26,"text":976,"url":26,"identifiers":977},"Dong ZT, 1982, Effect of danshensu on isolated swine coronary artery perfusion preparation, YaoxueXuebao, 17, 226",{},{"id":26,"text":979,"url":26,"identifiers":980},"Li CZ, 1983, Anticoagulant studies of Danshen, Zhongxiyi Jiehe Zazhi, 3, 297",{},{"id":26,"text":982,"url":26,"identifiers":983},"Cheng ZH, 1987, Studies on effects of “danshensu” on experimental microcirculatory disturbances and plasma lactic acid concentrations, Shanghai Yike Daxue Xuebao, 14, 25",{},{"id":26,"text":985,"url":26,"identifiers":986},"Tang LH, 1989, The protection of DS‐182 during reperfusion of total ischemia heart, Zhongguo Bingli Shengli Zazhi, 5, 65",{},{"id":26,"text":988,"url":26,"identifiers":989},"10.1016\u002FS0024-3205(03)00142-5",{"doi":988},{"id":26,"text":991,"url":26,"identifiers":992},"Su XH, 1992, The effect of danshensu (DS‐182) of the injury of oxygen free radicals in myocardial mitochondria from rat myocardium, Zhongguo Bingli Shengli Zazhi, 8, 122",{},{"id":26,"text":994,"url":26,"identifiers":995},"Zhao BL, 1996, Scavenging effects of Salvia miltiorrhiza on free radicals and its protection for myocardial mitochondrial membranes from ischemia‐reperfusion injury, Biochem Mol Biol Int, 38, 1171",{},{"id":26,"text":997,"url":26,"identifiers":998},"10.1016\u002Fj.lfs.2004.06.010",{"doi":997},{"id":26,"text":1000,"url":26,"identifiers":1001},"Chen YH, 2000, Salvianolic acid B protects brain against injuries caused by ischemia‐reperfusion in rats, Zhongguo Xinyao Zazhi, 21, 463",{},{"id":26,"text":1003,"url":26,"identifiers":1004},"Li M, 2004, Inhibition of shear‐induced platelet aggregation in rat by tetramethylpyrazine and salvianolic acid B, Clin Hemorheol Microcirc, 31, 97",{},{"id":26,"text":1006,"url":26,"identifiers":1007},"10.1016\u002FS0024-3205(00)00989-9",{"doi":1006},{"id":26,"text":1009,"url":26,"identifiers":1010},"10.1161\u002F01.ATV.18.3.481",{"doi":1009},{"id":26,"text":1012,"url":26,"identifiers":1013},"10.1023\u002FA:1007081911734",{"doi":1012},{"id":26,"text":1015,"url":26,"identifiers":1016},"10.1254\u002Fjjp.87.289",{"doi":1015},{"id":26,"text":1018,"url":26,"identifiers":1019},"10.1016\u002FS0006-2952(01)00686-4",{"doi":1018},{"id":26,"text":1021,"url":26,"identifiers":1022},"10.1016\u002Fj.lfs.2004.02.034",{"doi":1021},{"id":26,"text":1024,"url":26,"identifiers":1025},"10.1016\u002F0006-2952(93)90624-6",{"doi":1024},{"id":26,"text":1027,"url":26,"identifiers":1028},"10.1080\u002F10715760000301471",{"doi":1027},{"id":26,"text":1030,"url":26,"identifiers":1031},"10.1016\u002FS0006-2952(02)01250-9",{"doi":1030},{"id":26,"text":1033,"url":26,"identifiers":1034},"Zhuang YL, 1999, HPLC determination of danshensu and protocatechuic aldehyde in rat plasma, Yaoxue Xuebao, 34, 613",{},{"id":26,"text":1036,"url":26,"identifiers":1037},"Hong X, 2000, Pharmacokinetics study of danshensu in compound Danshen Dripping Pill, Zhongyao Xinyao yu Linchuang Yaoli, 11, 286",{},{"id":26,"text":1039,"url":26,"identifiers":1040},"Pan GX, 2003, Determination of danshensu in rat serum after oral administer compound Salvia Recipe, Zhongguo Zhongyao Zazhi, 28, 562",{},{"id":26,"text":1042,"url":26,"identifiers":1043},"10.1093\u002Fchromsci\u002F41.6.327",{"doi":1042},{"id":26,"text":1045,"url":26,"identifiers":1046},"He HB, 1983, Determination of danshensu and its pharmacokinetic parameter in rabbit by fluorometry, Shanghai Diyi Yixueyuan Xuebao, 10, 295",{},{"id":26,"text":1048,"url":26,"identifiers":1049},"10.1248\u002Fbpb.20.285",{"doi":1048},{"id":26,"text":1051,"url":26,"identifiers":1052},"10.1002\u002Fbmc.105",{"doi":1051},{"id":26,"text":1054,"url":26,"identifiers":1055},"Zhao XF, 2004, Qualitative and quantitative analysis of 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Drug Scale (ADS) scores were previously associated with serum anticholinergic activity (SAA) in a pilot study. 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(DHEA) and its sulfated metabolite DHEA‐S are endogenous hormones secreted by the adrenal cortex in response to adrenocorticotrophin (ACTH). Much has been published regarding potential effects on various systems. Despite the identification of DHEA and DHEA‐S more than 50 years ago, there is still considerable controversy as to their biological significance. This article reviews the metabolism and physiology of DHEA and DHEA‐S, the influence of age and gender on concentrations, and changes in endogenous concentrations associated with disease states and other factors, including diet and exercise. This article is unique in that it also summarizes the influence of drugs on DHEA and DHEA‐S concentrations, as well as concentrations of DHEA and DHEA‐S observed after the administration of DHEA by various routes. 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MA, 1997, The role of dehydroepiandrosterone in AIDS, Ann Pharmacother, 31, 639",{},{"id":26,"text":1930,"url":26,"identifiers":1931},"Hedman M, 1989, Low sulpho‐conjugated steroid hormone levels in systemic lupus erythematosus (SLE), Clin Exp Rheumatol, 7, 583",{},{"id":26,"text":1933,"url":26,"identifiers":1934},"10.1111\u002Fj.1365-2249.1995.tb05541.x",{"doi":1933},{"id":26,"text":1936,"url":26,"identifiers":1937},"Straub RH, 1996, Dehydroepiandrosterone sulfate is positively correlated with soluble interleukin 2 receptor and soluble intercellular adhesion molecule in systemic lupus erythematosus, J Rheumatol, 23, 856",{},{"id":26,"text":1939,"url":26,"identifiers":1940},"10.1002\u002Fart.1780381216",{"doi":1939},{"id":26,"text":1942,"url":26,"identifiers":1943},"Masi AT, 1995, Sex hormones and rheumatoid arthritis: cause or effect relationships in a complex pathophysiology?, Clin Exp Rheumatol, 13, 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C virus (HCV) infection is now a global public health issue. However, the global burden of disease attributable to HCV infection is unknown. The objectives of this WHO informal consultation included the following: (1) defining a strategy to estimate the global burden of disease (GBD) associated with HCV infection in terms of morbidity and mortality, (2) describing the natural history of HCV infection in terms of morbidity and mortality, and (3) identifying areas for which more research is needed. The GBD project is an attempt to examine all causes of morbidity and mortality using an approach common to all conditions. The World Health Organization (WHO) already has estimated the burden of disease associated with hepatitis B virus (HBV) infection and is now about to conduct the same analysis for HCV infection. A review has been conducted to estimate the prevalence of HCV infection by age, gender, and region. These figures can be used to estimate incidence, although there are a number of areas of uncertainty. Combined with natural history parameters, incidence estimates could be used to estimate the future burden due to current infections. However, the present model is not validated and requires calibration before it can be used. A consensus was reached over the strategies to be used to (1) estimate the current burden due to past infections and (2) estimate the future burden due to current infections. Provisional expert consensus was reached over natural history parameters and cofactors that influence them. However, systematic literature reviews and meta‐analysis are preferable for obtaining estimates to be included in models. Areas deserving future research include (1) obtaining a better estimate of HCV infection prevalence by age groups, (2) characterizing the various morbidity states associated with HCV infection and their disability weights, (3) understanding the long‐term natural history of HCV infection beyond 20 years after infection, and (4) estimating the prevalence (and numbers of) of HCV infection among the drug‐using population worldwide. A working group was created to address unmet needs and to assist the WHO in estimating the GBD associated with HCV infection.\u003C\u002Fjats:p>",{"EN":2039},"Global Burden of Disease (GBD) for Hepatitis C",{"VOID":2041},"14681338",{"VOID":2043},"10.1177\u002F0091270003258669","Author title is 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Paper presented at the 3rd Australasian Conference on Hepatitis C Melbourne Australia 2002.",{},{"id":26,"text":2162,"url":26,"identifiers":2163},"10.1002\u002Fhep.510290401",{"doi":2162},{"id":26,"text":2165,"url":26,"identifiers":2166},"10.1053\u002Fjhep.2001.24432",{"doi":2165},{"id":26,"text":2168,"url":26,"identifiers":2169},"10.1136\u002Fgut.51.1.89",{"doi":2168},{"id":26,"text":2171,"url":26,"identifiers":2172},"10.1007\u002FBF01691375",{"doi":2171},{"id":26,"text":2174,"url":26,"identifiers":2175},"Dore G, 1998, HIV and hepatitis C coinfection",{},{"id":26,"text":2177,"url":26,"identifiers":2178},"10.1111\u002Fj.1365-2893.1997.tb00183.x",{"doi":2177},{"id":26,"text":2180,"url":26,"identifiers":2181},"10.1002\u002Fhep.510280330",{"doi":2180},{"id":26,"text":2183,"url":26,"identifiers":2184},"10.7326\u002F0003-4819-134-2-200101160-00012",{"doi":2183},{"id":2186,"createTime":2187,"updateTime":2187,"relativeEntities":2188,"slug":2189,"properties":2190,"entityType":816,"verifyStatus":25,"verifyTime":2204,"verifyNote":817,"syncStatus":28,"languages":2205,"translateLanguages":26,"viewCount":36,"primaryUrl":2206,"fullTextUrl":26,"authors":2207,"publicationType":874,"publisherRelationship":2229,"citationCount":2267,"citationInfo":2268,"publishDate":2270,"publishYear":2271,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":2272,"isForceReanalyzing":1216},"6f4cdde6-71e0-429b-b8b9-b5d4f5ca0f43","2024-09-18T13:29:23.431+00:00",[],"Stability-and-Performance-of-a-Population-Pharmacokinetic-Model",{"mag":2191,"keywords":2193,"openalex":2194,"abstract":2196,"title":2198,"pm":2200,"doi":2202},{"VOID":2192},"1973097930",{},{"VOID":2195},"W1973097930",{"EN":2197},"\u003Cjats:p>This study aimed to determine the stability (in terms of covariate selection) of a population pharmacokinetic model and evaluate its performance in the absence of a test data set. Data from 88 full‐term infants, 11 of whom were human immunodeficiency virus (HIV)–seropositive, taking an antiinfective agent were analyzed using exploratory data analysis methods and the nonlinear mixed‐effects modeling (NONMEM) program to obtain the final population pharmacokinetic model. The stability of the population pharmacokinetic model was tested using the nonparametric bootstrap approach in four steps: 1) with the base pharmacokinetic model, 100 bootstrap replicates of the original data were generated by sampling with replacement; 2) ascertainment that each bootstrap data replicate was described by the basic structural model using the NONMEM objective function; 3) generalized additive modeling (GAM) applied to empiric Bayesian estimates for covariate selection at α = 0.05 and a frequency (f) cutoff value of 0.50; and 4) NONMEM population model building using covariates selected in the third step with α = 0.005. Performance of the population pharmacokinetic model was evaluated using 200 additional bootstrap replicates of the data by fitting the model obtained in step 4 to them. Parameters obtained were compared with those obtained in the model stability step, and improved prediction error, a measure of predictive accuracy as an index of internal validation, was computed. The reciprocal of serum creatinine (RSC; f = 0.73) and HIV (f = 0.70) were selected by GAM as predictors of clearance (Cl). The population pharmacokinetic model obtained without the determination of model stability included RSC as a predictor of Cl, but the final model from the model stability step included both HIV and RSC as predictors of Cl. Final population pharmacokinetic parameters were obtained with this model fitted to the original data; however, the 95% confidence interval on the HIV status regression coefficient included zero, indicating no significance. The mean parameter estimates obtained with the additional 200 bootstrap replicates of data were within 15% of those obtained with the final model at the regression stability step. 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authors' objective was to review previous studies of immediate (first 30 seconds) and stabilized (30 seconds to 20 minutes) hemodynamic responses of healthy adults to the head‐up posture, with particular reference to alteration of such responses in the elderly and the usefulness of such data in the diagnosis of orthostatic hypotension. The immediate response in healthy young adults is characterized by a prompt rise in heart rate, which peaks at about 8 to 15 seconds and then tapers; the arterial pressure and total vascular resistance decrease sharply at 5 to 10 seconds, followed by a rapid rebound and overshoot. Over the first 30 seconds there is a steady parallel decline of thoracic blood volume and stroke volume; there is also an initial surge of cardiac output followed by a steady decrease. During the stabilized response (30 seconds to 20 minutes), the hemodynamic variables are relatively steady, showing average increases in heart rate of about 15 to 30%, in diastolic pressure of 10 to 15%, and in total vascular resistance of 30 to 40%; during the 5th to 20th minutes there are also decreases in thoracic blood volume averaging about 25 to 30%, in cardiac output 15 to 30%, and in pulse pressure about 5 to 10%. It is evident that in normal human subjects, assumption of the upright posture results in profound hemodynamic changes, most of them occurring during the first 30 seconds. In elderly subjects (aged 60–69 years), there are, in the upright posture, lesser increments of heart rate and diastolic pressure, but no significant differences from younger age groups in the response of thoracic blood volume, cardiac output or total vascular resistance. However, beginning at about age 75, there is an increasing incidence of orthostatic hypotension, which averages about 14 to 20% at age 75 and older. The tendency toward orthostatic hypotension in the elderly is due (1) to the structural and functional changes in the circulation itself, (2) to a decline in autonomic function, and (3) to a probable functional deficiency of the skeletal muscle pump. The authors believe that closer hemodynamic monitoring of orthostatic hypotension patients would considerably increase our understanding and aid in the diagnosis of this condition.\u003C\u002Fjats:p>",{"EN":2887},"Hemodynamic Response to the Upright Posture",{"VOID":2889},"8089249",{"VOID":2891},"10.1002\u002Fj.1552-4604.1994.tb04977.x",[102],"https:\u002F\u002Faccp1.onlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fj.1552-4604.1994.tb04977.x",[2895,2916,2933],{"id":2896,"sortIndex":36,"researcher":26,"roles":2897,"affiliations":2898,"properties":2909},"afbd9bf1-8f4d-44cb-98ff-47ba725bbb58",[],[2899],{"id":2900,"sortIndex":36,"affiliation":2901,"properties":26},"41227b4e-8a12-4a98-a3ee-538dd8865b57",{"id":2902,"createTime":2903,"updateTime":2903,"relativeEntities":2904,"slug":2905,"properties":2906,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"c34a641d-5887-4de2-8fe9-2594df2d3ebd","2024-10-11T05:48:32.477+00:00",[],"Department-of-Physiology-Medical-College-of-Wisconsin-The-University-of-Wisconsin-Milwaukee-School-of-Nursing-and-the-Zablocki-Veterans-Administration-Medical-Center-Milwaukee-Wisconsin-",{"title":2907},{"EN":2908},"Department of Physiology, Medical College of Wisconsin, The University of Wisconsin‐Milwaukee School of Nursing, and the Zablocki Veterans Administration Medical Center, Milwaukee, Wisconsin.",{"openalex":2910,"orcid":2912,"title":2914},{"VOID":2911},"A5051793179",{"VOID":2913},"https:\u002F\u002Forcid.org\u002F0000-0003-1492-3095",{"EN":2915},"James J. 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309",{},{"id":3151,"createTime":3152,"updateTime":3152,"relativeEntities":3153,"slug":3154,"properties":3155,"entityType":816,"verifyStatus":25,"verifyTime":3152,"verifyNote":817,"syncStatus":28,"languages":3169,"translateLanguages":26,"viewCount":36,"primaryUrl":3170,"fullTextUrl":26,"authors":3171,"publicationType":874,"publisherRelationship":3318,"citationCount":3354,"citationInfo":3355,"publishDate":3357,"publishYear":919,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":3358,"isForceReanalyzing":1216},"24ec25e3-e1fa-4605-984e-ec181b16922f","2024-09-04T01:09:06.536+00:00",[],"Pharmacokinetic-Profile-of-the-Oral-Direct-Thrombin-Inhibitor-Dabigatran-Etexilate-in-Healthy-Volunteers-and-Patients-Undergoing-Total-Hip-Replacement",{"mag":3156,"keywords":3158,"openalex":3159,"abstract":3161,"title":3163,"pm":3165,"doi":3167},{"VOID":3157},"2035193897",{},{"VOID":3160},"W2035193897",{"EN":3162},"\u003Cjats:p>Dabigatran etexilate is an oral 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Following oral administration, dabigatran etexilate is rapidly converted to its active form, dabigatran. The authors investigated the absorption, distribution, and elimination of a single 150‐mg dose capsule formulation of dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement. In an open‐label, 3‐way crossover study, dabigatran etexilate was administered to 18 male volunteers in the fasted state, after administration of food and with coadministration of the proton pump inhibitor, pantoprazole. In a subsequent multicenter, open‐label study, 59 patients received a single dose of dabigatran etexilate, administered 1 to 3 hours following total hip replacement. In healthy volunteers, food had no effect on the extent of absorption of dabigatran etexilate, although there was reduced interindividual variability for dabigatran maximum plasma concentration and AUC\u003Cjats:sub>\u003Cjats:italic>0‐∞\u003C\u002Fjats:italic>\u003C\u002Fjats:sub>. A decrease in the mean dabigatran AUC\u003Cjats:sub>\u003Cjats:italic>0‐∞\u003C\u002Fjats:italic>\u003C\u002Fjats:sub> (904 to 705 ng•h\u002FmL) occurred with coadministration of pantoprazole. In patients undergoing total hip replacement, immediate onset of absorption was seen with the maximum plasma concentration of dabigatran occurring after 6 hours. The AUC\u003Cjats:sub>\u003Cjats:italic>0–24\u003C\u002Fjats:italic>\u003C\u002Fjats:sub> of dabigatran was 88% of the steady‐state AUC using a preliminary tablet formulation and 106% of that seen in the healthy volunteer study. Compared with healthy volunteers, the postoperative profile was flattened with delayed peak concentrations. In summary, administration of the dabigatran etexilate capsule with food has no effect on the extent of dabigatran absorption, with a moderate decrease when coadministered with pantoprazole. Adequate plasma concentrations of dabigatran were seen with early postoperative administration of the dabigatran etexilate capsule. 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A large‐scale effort was initiated in 1992 to screen traditional Chinese medicines that were suspected of adulteration with synthetic therapeutic substances. The term “adulteration” refers to traditional Chinese medicines that are tested and found to contain chemical substances not prescribed or labeled as part of the intended use. A total of 2,609 samples were collected by eight major general hospitals in Taiwan. Samples were collected through physicians' referrals during patient visits. The samples were analyzed by hospital pharmacists following the established standard procedures in comparison to references by thin‐layer chromatography. An average of 23.7% (n = 618) of the samples collected from the eight hospitals were adulterated. Four samples with either a rheumatoid or an antiinflammatory indication contained six different kinds of adulterants. More than half (52.8%) of the adulterated traditional Chinese medicines contained two or more adulterants. 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