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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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TCS is commonly detected in aquatic ecosystems, as it is only partially removed during the wastewater treatment process. Sorption, biodegradation and photolytic degradation mitigate the availability of TCS to aquatic biota; however the by‐products such as methyltriclosan and other chlorinated phenols may be more resistant to degradation and have higher toxicity than the parent compound. The continuous exposure of aquatic organisms to TCS, coupled with its bioaccumulation potential, have led to detectable levels of the antimicrobial in a number of aquatic species. TCS has been also detected in breast milk, urine and plasma, with levels of TCS in the blood correlating with consumer use patterns of the antimicrobial. Mammalian systemic toxicity studies indicate that TCS is neither acutely toxic, mutagenic, carcinogenic, nor a developmental toxicant. Recently, however, concern has been raised over TCS's potential for endocrine disruption, as the antimicrobial has been shown to disrupt thyroid hormone homeostasis and possibly the reproductive axis. Moreover, there is strong evidence that aquatic species such as algae, invertebrates and certain types of fish are much more sensitive to TCS than mammals. TCS is highly toxic to algae and exerts reproductive and developmental effects in some fish. The potential for endocrine disruption and antibiotic cross‐resistance highlights the importance of the judicious use of TCS, whereby the use of TCS should be limited to applications where it has been shown to be effective. 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The hexavalent chromium compounds appear to be 10–100 times more toxic than the trivalent chromium compounds when both are administered by the oral route. Dermal irritancy and allergy are more frequently caused by contact with soluble hexavalent chromium compounds. The cytotoxicity of soluble and insoluble hexavalent chromium compounds to fibroblasts is 100‐1000 times greater than that demonstrated by trivalent chromium compounds. In short‐term tests, the hexavalent chromium compounds demonstrated genotoxic effects four times more frequently than did the trivalent chromium compounds. Carcinogenicity appears to be associated with the inhalation of the less soluble\u002Finsoluble hexavalent chromium compounds. The toxicology of chromium does not reside with the elemental form. It varies greatly among a wide variety of very different chromium compounds. Oxidation state and solubility are particularly important factors in considering the toxicity of chromium with respect to its chemical speciation.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Các tính chất của crom hóa trị ba và hóa trị sáu được xem xét liên quan đến độc tính miệng cấp tính và mãn tính, độc tính da, độc tính hệ thống, độc tính học, độc tính tế bào, độc tính di truyền và khả năng gây ung thư. Các hợp chất crom hóa trị sáu có vẻ độc hơn 10–100 lần so với các hợp chất crom hóa trị ba khi cả hai được sử dụng qua đường miệng. Tình trạng kích ứng da và dị ứng thường xảy ra hơn khi tiếp xúc với các hợp chất crom hóa trị sáu tan. Độc tính tế bào của các hợp chất crom hóa trị sáu tan và không tan đối với tế bào sợi cao hơn từ 100‐1000 lần so với các hợp chất crom hóa trị ba. Trong các bài kiểm tra ngắn hạn, các hợp chất crom hóa trị sáu thể hiện tác động di truyền thường xuyên gấp bốn lần so với các hợp chất crom hóa trị ba. Khả năng gây ung thư dường như liên quan đến việc hít phải các hợp chất crom hóa trị sáu kém tan\u002Fkhông tan. Độc tính học của crom không phụ thuộc vào dạng nguyên tố của nó. Nó thay đổi đáng kể giữa một loạt các hợp chất crom rất khác nhau. Trạng thái oxy hóa và độ tan đặc biệt là những yếu tố quan trọng trong việc xem xét độc tính của crom liên quan đến sự phân loại hóa học của nó.\u003C\u002Fjats:p>",{"EN":1583,"VI":1584},"The toxicology of chromium with respect to its chemical speciation: A review","Độc tính của crom liên quan đến đặc điểm hóa học của nó: Một đánh giá",{"VOID":1586},"8326093",{"VOID":1588},"10.1002\u002Fjat.2550130314",[31],[30],"https:\u002F\u002Fanalyticalsciencejournals.onlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fjat.2550130314",[1593,1610],{"id":1594,"sortIndex":32,"researcher":28,"roles":1595,"affiliations":1596,"properties":1605,"displayName":1607,"givenName":28,"familyName":28},"84259d83-de45-4729-b261-1015f24fe537",[],[1597],{"id":1598,"sortIndex":32,"affiliation":1599,"properties":28},"61a71c42-97c6-4f26-9147-113bc701d941",{"id":1598,"createTime":28,"updateTime":28,"relativeEntities":1600,"slug":28,"properties":1601,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1604,"statistic":28},[],{"title":1602},{"EN":1603},"Rutgers University, Camden, NJ 08102-1205, USA",[],{"title":1606,"openalex":1608},{"EN":1607},"Sidney Katz",{"VOID":1609},"A5111719232",{"id":1611,"sortIndex":40,"researcher":28,"roles":1612,"affiliations":1613,"properties":1622,"displayName":1624,"givenName":28,"familyName":28},"fe2f10bd-25e9-46f8-b651-46d0c60a8557",[],[1614],{"id":1615,"sortIndex":32,"affiliation":1616,"properties":28},"393afb42-72d2-4fea-98cb-a2659247b897",{"id":1615,"createTime":28,"updateTime":28,"relativeEntities":1617,"slug":28,"properties":1618,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1621,"statistic":28},[],{"title":1619},{"EN":1620},"Chemical Research Development, and Engineering Centre, Toxicology Division, Aberdeen Proving Ground, MD 21010-5423, USA",[],{"title":1623,"openalex":1625},{"EN":1624},"Harry Salem",{"VOID":1626},"A5112076742",{"url":28,"publisher":1628,"properties":1666},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1629,"slug":872,"properties":1630,"entityType":25,"verifyStatus":884,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1635,"manageAffiliations":1640,"indexDatabases":1651,"url":936,"thumbnailPath":28,"statistic":28,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"country":1631,"eissn":1632,"issn":1633,"title":1634},{"VOID":875},{"VOID":877},{"VOID":879},{"EN":881},[1636],{"id":887,"createTime":28,"updateTime":28,"relativeEntities":1637,"label":1638,"description":1639,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},[1641,1646],{"id":894,"createTime":28,"updateTime":28,"relativeEntities":1642,"slug":28,"properties":1643,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1645,"statistic":28},[],{"title":1644},{"EN":898},[],{"id":901,"createTime":28,"updateTime":28,"relativeEntities":1647,"slug":28,"properties":1648,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1650,"statistic":28},[],{"title":1649},{"EN":905},[],[1652,1659],{"id":909,"indexDatabase":1653,"url":915,"indexYears":916,"academicFieldIds":1658,"indexDatabaseRanking":919},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":1654,"label":1655,"description":1656,"key":781,"publicationTags":1657,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[918],{"id":921,"indexDatabase":1660,"url":933,"indexYears":28,"academicFieldIds":1665,"indexDatabaseRanking":28},{"id":923,"createTime":28,"updateTime":28,"relativeEntities":1661,"label":1662,"description":1663,"key":930,"publicationTags":1664,"standard":28},[],{"EN":926,"VI":926},{"EN":928,"VI":929},[932,813],[935],{"issue":1667,"pages":1669,"volume":1671},{"VOID":1668},"3",{"VOID":1670},"217-224",{"VOID":1672},"13",568,{"total":1673,"publishYear":1675,"statisticByYear":1676},1993,{"2012":131,"2013":278,"2014":135,"2015":137,"2016":137,"2017":69,"2018":328,"2019":131,"2020":139,"2021":148,"2022":69,"2023":69,"2024":145},"1993-05-01",[919,932],[1680,1683,1686,1689,1692,1695,1698,1701,1704,1707,1710,1713,1716,1719,1722,1725,1728,1731,1734,1737,1740,1743,1746,1749,1752,1755,1758,1761,1764,1767,1770,1773,1776,1779,1783,1786,1789,1792,1795,1798,1801,1804,1807,1810,1813,1816,1819,1822,1825,1829,1832,1835,1838,1841,1844,1847,1850,1853,1856,1859,1862,1865,1868,1871,1874,1877,1880,1883,1886,1889,1892,1895,1898,1901,1904,1907,1911,1914,1917,1920,1923,1926,1929,1932],{"id":28,"text":1681,"url":28,"identifiers":1682},"10.1002\u002Ftcm.1770050507",{"doi":1681},{"id":28,"text":1684,"url":28,"identifiers":1685},"Levy L. S., 1936, Investigation of the potential carcinogenicity of a range of chromium containing materials on rat lung, Br. J. Ind. Med., 43, 243",{},{"id":28,"text":1687,"url":28,"identifiers":1688},"Samitz M. H., 1955, Some dermatologic aspects of the chromate problem, Arch. Ind. Health, 11, 361",{},{"id":28,"text":1690,"url":28,"identifiers":1691},"Popper H. H., 1991, Progress in Histo‐Cytochemistry as a Tool in Environmental Toxicology, 220",{},{"id":28,"text":1693,"url":28,"identifiers":1694},"10.1292\u002Fjvms.54.281",{"doi":1693},{"id":28,"text":1696,"url":28,"identifiers":1697},"10.1080\u002F02772248909357424",{"doi":1696},{"id":28,"text":1699,"url":28,"identifiers":1700},"10.1080\u002F02772248809357274",{"doi":1699},{"id":28,"text":1702,"url":28,"identifiers":1703},"10.1080\u002F02772248909357455",{"doi":1702},{"id":28,"text":1705,"url":28,"identifiers":1706},"10.1152\u002Fphysrev.1969.49.2.163",{"doi":1705},{"id":28,"text":1708,"url":28,"identifiers":1709},"10.1016\u002F0048-9697(89)90196-4",{"doi":1708},{"id":28,"text":1711,"url":28,"identifiers":1712},"Schroeder H. A., 1963, Effect of chromium, cadmium and lead on the growth and survival of rats, J. Nutr., 80, 39",{},{"id":28,"text":1714,"url":28,"identifiers":1715},"Emsley J., 1989, The Elements, 50",{},{"id":28,"text":1717,"url":28,"identifiers":1718},"10.1016\u002F0039-9140(76)80040-9",{"doi":1717},{"id":28,"text":1720,"url":28,"identifiers":1721},"10.1021\u002Fja01326a010",{"doi":1720},{"id":28,"text":1723,"url":28,"identifiers":1724},"Rieman W., 1951, J. Am. Chem. Soc., 325",{},{"id":28,"text":1726,"url":28,"identifiers":1727},"Weast R. C., 1970, CRC Handbook of Chemistry and Physics",{},{"id":28,"text":1729,"url":28,"identifiers":1730},"Dean J. A., 1979, Lang's Handbook of Chemistry",{},{"id":28,"text":1732,"url":28,"identifiers":1733},"Dean J. A., 1985, Lang's Handbook of Chemistry",{},{"id":28,"text":1735,"url":28,"identifiers":1736},"Linke W. F., 1958, Solubilities of Inorganic and Metal‐Organic Compounds",{},{"id":28,"text":1738,"url":28,"identifiers":1739},"10.1093\u002Fcarcin\u002F12.4.551",{"doi":1738},{"id":28,"text":1741,"url":28,"identifiers":1742},"Registry of Toxic Effects of Chemical Substances, 1986, US Department of Health and Human Services, Public Health Service, Centers for Disease Control",{},{"id":28,"text":1744,"url":28,"identifiers":1745},"Samitz M. H., 1964, A current review of the chromate problem, Dermatol. Dig., 3, 18",{},{"id":28,"text":1747,"url":28,"identifiers":1748},"Samitz M. H., 1962, Studies on the prevention of the injurious effects of chromates in industry, Ind. Med. Surg., 31, 427",{},{"id":28,"text":1750,"url":28,"identifiers":1751},"MacKenzie R. D., 1958, Chronic toxicity studies. II. Hexavalent and trivalent chromium administered in drinking water to rats, Arch. Ind. Health, 18, 232",{},{"id":28,"text":1753,"url":28,"identifiers":1754},"10.1093\u002Fjn\u002F86.1.51",{"doi":1753},{"id":28,"text":1756,"url":28,"identifiers":1757},"10.1016\u002FS0015-6264(75)80298-7",{"doi":1756},{"id":28,"text":1759,"url":28,"identifiers":1760},"10.1080\u002F00039896.1962.10663312",{"doi":1759},{"id":28,"text":1762,"url":28,"identifiers":1763},"10.1001\u002Farchderm.1961.01580150050009",{"doi":1762},{"id":28,"text":1765,"url":28,"identifiers":1766},"10.1038\u002Fjid.1963.83",{"doi":1765},{"id":28,"text":1768,"url":28,"identifiers":1769},"10.1001\u002Farchderm.1964.01600010010003",{"doi":1768},{"id":28,"text":1771,"url":28,"identifiers":1772},"10.1001\u002Farchderm.1965.01600090041007",{"doi":1771},{"id":28,"text":1774,"url":28,"identifiers":1775},"Fregert S., 1966, Allergy to chromium, nickel and cobalt, Arch. Dermatol Venerol., 46, 144",{},{"id":28,"text":1777,"url":28,"identifiers":1778},"10.1001\u002Farchderm.93.1.34",{"doi":1777},{"id":28,"text":1780,"url":28,"identifiers":1781},"Samitz M. H., 1966, Patch test reactions to hexavalent and trivalent chromium compounds, Arch. Dermatol., 94, 304, 10.1001\u002Farchderm.1966.01600270054010",{"doi":1782},"10.1001\u002Farchderm.1966.01600270054010",{"id":28,"text":1784,"url":28,"identifiers":1785},"Valer M., 1971, Investivation concerning the sensitizing effect of trivalent chromium salts, Berufs‐Dermatosen, 6, 302",{},{"id":28,"text":1787,"url":28,"identifiers":1788},"10.1177\u002F096032719101000315",{"doi":1787},{"id":28,"text":1790,"url":28,"identifiers":1791},"10.1177\u002F096032719101000207",{"doi":1790},{"id":28,"text":1793,"url":28,"identifiers":1794},"10.1159\u002F000181540",{"doi":1793},{"id":28,"text":1796,"url":28,"identifiers":1797},"10.1093\u002Fjat\u002F12.3.162",{"doi":1796},{"id":28,"text":1799,"url":28,"identifiers":1800},"10.1007\u002FBF00398817",{"doi":1799},{"id":28,"text":1802,"url":28,"identifiers":1803},"10.3109\u002F15563658209025729",{"doi":1802},{"id":28,"text":1805,"url":28,"identifiers":1806},"10.1016\u002F0041-008X(81)90111-3",{"doi":1805},{"id":28,"text":1808,"url":28,"identifiers":1809},"10.1016\u002F0300-483X(77)90023-3",{"doi":1808},{"id":28,"text":1811,"url":28,"identifiers":1812},"10.1016\u002F0041-008X(86)90384-4",{"doi":1811},{"id":28,"text":1814,"url":28,"identifiers":1815},"10.1007\u002FBF01973713",{"doi":1814},{"id":28,"text":1817,"url":28,"identifiers":1818},"10.1093\u002Fannhyg\u002F27.3.315",{"doi":1817},{"id":28,"text":1820,"url":28,"identifiers":1821},"10.1016\u002F0048-9697(89)90193-9",{"doi":1820},{"id":28,"text":1823,"url":28,"identifiers":1824},"10.1152\u002Fajplegacy.1965.209.4.731",{"doi":1823},{"id":28,"text":1826,"url":28,"identifiers":1827},"Mertz W., 1965, Biological activity and fate of trace quantities of intravenous chromium(III) in the rat, Am. J. Physiol., 209, 614, 10.1152\u002Fajplegacy.1965.209.3.489",{"doi":1828},"10.1152\u002Fajplegacy.1965.209.3.489",{"id":28,"text":1830,"url":28,"identifiers":1831},"10.1248\u002Fbpb1978.3.17",{"doi":1830},{"id":28,"text":1833,"url":28,"identifiers":1834},"10.2486\u002Findhealth.21.25",{"doi":1833},{"id":28,"text":1836,"url":28,"identifiers":1837},"10.1172\u002FJCI102403",{"doi":1836},{"id":28,"text":1839,"url":28,"identifiers":1840},"10.3891\u002Facta.chem.scand.13-0456",{"doi":1839},{"id":28,"text":1842,"url":28,"identifiers":1843},"10.1007\u002FBF02992700",{"doi":1842},{"id":28,"text":1845,"url":28,"identifiers":1846},"Anhgileri L. J., 1965, Fate of injected homologour 51Cr labeled sero‐albumin in rats, Nuc. Med., 9, 364",{},{"id":28,"text":1848,"url":28,"identifiers":1849},"Lim T. H., 1983, Kinetics of trace element chromium(III) in the human body, Am. J. Physiol., 244, 445",{},{"id":28,"text":1851,"url":28,"identifiers":1852},"Biedermann K. A., 1990, Role of valence state and solubility of chromium compounds on induction of cytotoxicity, mutagenesis, and anchorage independence in diploid human fibroblasts, Cancer Res., 50, 7835",{},{"id":28,"text":1854,"url":28,"identifiers":1855},"10.1007\u002FBF01973630",{"doi":1854},{"id":28,"text":1857,"url":28,"identifiers":1858},"10.1093\u002Fcarcin\u002F12.10.1811",{"doi":1857},{"id":28,"text":1860,"url":28,"identifiers":1861},"10.1016\u002F0272-0590(88)90322-3",{"doi":1860},{"id":28,"text":1863,"url":28,"identifiers":1864},"10.1016\u002F0022-1759(91)90217-4",{"doi":1863},{"id":28,"text":1866,"url":28,"identifiers":1867},"10.1016\u002F0022-1759(92)90257-T",{"doi":1866},{"id":28,"text":1869,"url":28,"identifiers":1870},"10.1016\u002F0925-4439(92)90046-P",{"doi":1869},{"id":28,"text":1872,"url":28,"identifiers":1873},"10.1016\u002F0165-1110(90)90007-X",{"doi":1872},{"id":28,"text":1875,"url":28,"identifiers":1876},"Baetjer A. M., 1950, Pulmonary carcinoma in chromate workers. I. A review of the literature and report of cases, Arch. Ind. Hyg. Occup., 2, 487",{},{"id":28,"text":1878,"url":28,"identifiers":1879},"Baetjer A. M., 1950, Pulmonary carcinoma in chromate workers. II. Incidence on basis of hospital records, Arch. Ind. Hyg. Occup. Med., 2, 505",{},{"id":28,"text":1881,"url":28,"identifiers":1882},"Bidstrup P. L., 1951, Carcinoma of the lung in chromate workers, Br. J. Ind. Med., 8, 302",{},{"id":28,"text":1884,"url":28,"identifiers":1885},"Bidstrup P. L., 1956, Carcinoma in the lung of workmen in the bichromate‐producing industry in Great Britain, Br. J. Ind. Med., 13, 260",{},{"id":28,"text":1887,"url":28,"identifiers":1888},"10.1055\u002Fs-0028-1122461",{"doi":1887},{"id":28,"text":1890,"url":28,"identifiers":1891},"10.1093\u002Fije\u002F8.4.365",{"doi":1890},{"id":28,"text":1893,"url":28,"identifiers":1894},"10.1016\u002F0013-9351(75)90072-9",{"doi":1893},{"id":28,"text":1896,"url":28,"identifiers":1897},"10.1016\u002F0013-9351(75)90079-1",{"doi":1896},{"id":28,"text":1899,"url":28,"identifiers":1900},"10.1007\u002FBF00406930",{"doi":1899},{"id":28,"text":1902,"url":28,"identifiers":1903},"10.5271\u002Fsjweh.2413",{"doi":1902},{"id":28,"text":1905,"url":28,"identifiers":1906},"Satoh K., 1981, Epidemiological study of workers engaged in the manufacture of chromium compounds, J. Occup. Med., 23, 835",{},{"id":28,"text":1908,"url":28,"identifiers":1909},"U.Glaser D.HochrainerandH.Oldiges Investigation of the lung carcinogenic potentials of sodium dichromate and Cr VI\u002FIII oxide aerosols in Wistar rats. First European Meeting on Environmental Hygiene pp.111–116(1988).",{"doi":1910},"10.1007\u002F978-3-642-73766-4_24",{"id":28,"text":1912,"url":28,"identifiers":1913},"Hueper W. C., 1961, Environmental carcinogens and cancers, Cancer Res., 21, 824",{},{"id":28,"text":1915,"url":28,"identifiers":1916},"10.1080\u002F00039896.1962.10663311",{"doi":1915},{"id":28,"text":1918,"url":28,"identifiers":1919},"10.1093\u002Fjn\u002F83.3.239",{"doi":1918},{"id":28,"text":1921,"url":28,"identifiers":1922},"10.1038\u002Fbjc.1975.201",{"doi":1921},{"id":28,"text":1924,"url":28,"identifiers":1925},"Laskin S., 1970, Inhalation Carcinogenesis",{},{"id":28,"text":1927,"url":28,"identifiers":1928},"Nettesheim P., 1971, Effect of calcium chromate dust, influenza virus, and 100 R whole body X‐radiation on lung tumor incidence in mice, J. Natl. Cancer Inst., 47, 1129",{},{"id":28,"text":1930,"url":28,"identifiers":1931},"Laskin S., 1972, Research in Environmental Sciences, 92",{},{"id":28,"text":1933,"url":28,"identifiers":1934},"Sixth Annual Report on Carcinogens Summary 1991 pp.52–53. US Department of Health and Human Services Public Health Service Washington DC (1991).",{},{"id":1936,"createTime":1937,"updateTime":1937,"relativeEntities":1938,"slug":1939,"properties":1940,"entityType":959,"verifyStatus":26,"verifyTime":1937,"verifyNote":960,"languages":1953,"translateLanguages":28,"viewCount":32,"primaryUrl":1954,"fullTextUrl":28,"authors":1955,"publicationType":996,"publisherRelationship":2007,"citationCount":2053,"citationInfo":2054,"publishDate":2057,"publishYear":2055,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":2058,"openAccess":28,"references":2059,"isForceReanalyzing":1565},"5d02804f-115b-4324-ade4-ee1634914eef","2024-09-19T21:58:35.361+00:00",[],"Impact-of-glyphosate-and-glyphosate-based-herbicides-on-the-freshwater-environment",{"openalex":1941,"mag":1943,"abstract":1945,"title":1947,"pm":1949,"doi":1951},{"VOID":1942},"W2102850007",{"VOID":1944},"2102850007",{"EN":1946},"\u003Cjats:title>ABSTRACT\u003C\u002Fjats:title>\u003Cjats:p>Glyphosate [\u003Cjats:italic>N\u003C\u002Fjats:italic>‐(phosphonomethyl) glycine] is a broad spectrum, post emergent herbicide and is among the most widely used agricultural chemicals globally. Initially developed to control the growth of weed species in agriculture, this herbicide also plays an important role in both modern silviculture and domestic weed control. The creation of glyphosate tolerant crop species has significantly increased the demand and use of this herbicide and has also increased the risk of exposure to non‐target species. Commercially available glyphosate‐based herbicides are comprised of multiple, often proprietary, constituents, each with a unique level of toxicity. Surfactants used to increase herbicide efficacy have been identified in some studies as the chemicals responsible for toxicity of glyphosate‐based herbicides to non‐target species, yet they are often difficult to chemically identify. Most glyphosate‐based herbicides are not approved for use in the aquatic environment; however, measurable quantities of the active ingredient and surfactants are detected in surface waters, giving them the potential to alter the physiology of aquatic organisms. Acute toxicity is highly species dependant across all taxa, with toxicity depending on the timing, magnitude, and route of exposure. The toxicity of glyphosate to amphibians has been a major focus of recent research, which has suggested increased sensitivity compared with other vertebrates due to their life history traits and reliance on both the aquatic and terrestrial environments. This review is designed to update previous reviews of glyphosate‐based herbicide toxicity, with a focus on recent studies of the aquatic toxicity of this class of chemicals. 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pollution is an increasing problem in the industrial world. Aromatic nitro compounds comprise a significant portion of the threat. In this review, the class includes nitro derivatives of benzene, biphenyls, naphthalenes, benzanthrone and polycyclic aromatic hydrocarbons, plus nitroheteroaromatic compounds. The numerous toxic manifestations are discussed. An appreciable number of drugs incorporate the nitroaromatic structure. The mechanistic aspects of both toxicity and therapy are addressed in the context of a unifying mechanism involving electron transfer, reactive oxygen species, oxidative stress and antioxidants. 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Monkey, pig, rat, rabbit, guinea pig, hairless rodents, such as hairless rat, hairless mouse, hairless guinea pig and hairless dog, are among the most used animals for this purpose. Each animal model has its own advantages and weakness or limitation. To better correlate animal data with human skin absorption, we need to be familiar with each animal model's characteristics as well as experimental method and condition. We reviewed the original papers published after 1993 that described permeability of both animal skin and human skin. It showed that monkey, pig and hairless guinea pig are more predictive of human skin absorption\u002Fpenetration and common laboratory animals, such as rat, rabbit, guinea pig, generally overestimate human skin absorption\u002Fpenetration. Copyright © 2014 John Wiley & Sons, Ltd.\u003C\u002Fjats:p>","\u003Cjats:title>TÓM TẮT\u003C\u002Fjats:title>\u003Cjats:p>Các mô hình động vật là công cụ quan trọng để dự đoán sự hấp thụ\u002F thẩm thấu qua da ở người \u003Cjats:italic>in vivo\u003C\u002Fjats:italic>. Khỉ, lợn, chuột, thỏ, chuột lang, và các loài gặm nhấm không lông, như chuột không lông, chuột lang không lông và chó không lông, là một trong những loài động vật được sử dụng nhiều nhất cho mục đích này. Mỗi mô hình động vật có những ưu điểm và điểm yếu hoặc giới hạn riêng của nó. Để liên kết tốt hơn dữ liệu động vật với sự hấp thụ qua da ở người, chúng ta cần làm quen với các đặc điểm của từng mô hình động vật cũng như phương pháp và điều kiện thí nghiệm. Chúng tôi đã xem xét các tài liệu gốc được công bố sau năm 1993 mô tả tính thẩm thấu của cả da động vật và da người. Kết quả cho thấy khỉ, lợn và chuột lang không lông có khả năng dự đoán tốt hơn sự hấp thụ\u002F thẩm thấu qua da ở người, trong khi các động vật thí nghiệm thông thường như chuột, thỏ, và chuột lang thường đánh giá quá cao sự hấp thụ\u002F thẩm thấu qua da ở người. Bản quyền © 2014 John Wiley & Sons, Ltd.\u003C\u002Fjats:p>",{"EN":3069,"VI":3070},"Animal models for percutaneous absorption","Mô hình động vật cho sự hấp thụ qua da",{"VOID":3072},"25345378",{"VOID":3074},"10.1002\u002Fjat.3004",[31],[30],"https:\u002F\u002Fanalyticalsciencejournals.onlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fjat.3004",[3079,3098],{"id":3080,"sortIndex":32,"researcher":28,"roles":3081,"affiliations":3082,"properties":3091,"displayName":3095,"givenName":28,"familyName":28},"8a995340-7e41-4dfa-8d49-04f495e18625",[],[3083],{"id":3084,"sortIndex":32,"affiliation":3085,"properties":28},"98687a5b-2f84-44ba-b81e-65b6ff28c5a7",{"id":3084,"createTime":28,"updateTime":28,"relativeEntities":3086,"slug":28,"properties":3087,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3090,"statistic":28},[],{"title":3088},{"EN":3089},"Department of Dermatology, 90 Medical Center Way, Surge 110 University of California San Francisco CA 94143-0989 USA",[],{"orcid":3092,"title":3094,"openalex":3096},{"VOID":3093},"https:\u002F\u002Forcid.org\u002F0000-0001-5076-9596",{"EN":3095},"Eui Chang Jung",{"VOID":3097},"A5077252505",{"id":3099,"sortIndex":40,"researcher":28,"roles":3100,"affiliations":3101,"properties":3110,"displayName":3114,"givenName":28,"familyName":28},"e5ee7c10-4e0f-484b-aa65-e49afd7311bc",[],[3102],{"id":3103,"sortIndex":32,"affiliation":3104,"properties":28},"4104a565-1215-499e-b835-233914d99978",{"id":3103,"createTime":28,"updateTime":28,"relativeEntities":3105,"slug":28,"properties":3106,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3109,"statistic":28},[],{"title":3107},{"EN":3108},"Department of Dermatology, 90 Medical Center Way, Surge 110 University of California San Francisco CA 94143‐0989 USA",[],{"orcid":3111,"title":3113,"openalex":3115},{"VOID":3112},"https:\u002F\u002Forcid.org\u002F0000-0002-6762-4016",{"EN":3114},"Howard I. 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Lab. Anim., 34, 499",{},{"id":28,"text":3233,"url":28,"identifiers":3234},"10.1002\u002Fjat.1505",{"doi":3233},{"id":28,"text":3236,"url":28,"identifiers":3237},"10.1002\u002Fjps.10405",{"doi":3236},{"id":28,"text":3239,"url":28,"identifiers":3240},"10.1159\u002F000135638",{"doi":3239},{"id":28,"text":3242,"url":28,"identifiers":3243},"OECD.2004.OECD Guideline for The Testing Of Chemicals.Skin Absorption: In Vitro Method. 428.OECD Paris.",{},{"id":28,"text":3245,"url":28,"identifiers":3246},"Panchagnula R, 1997, Animal models for transdermal drug delivery, Methods Find. Exp. Clin. Pharmacol., 19, 335",{},{"id":28,"text":3248,"url":28,"identifiers":3249},"10.1016\u002Fj.tiv.2003.08.002",{"doi":3248},{"id":28,"text":3251,"url":28,"identifiers":3252},"10.1191\u002F0960327104ht471oa",{"doi":3251},{"id":28,"text":3254,"url":28,"identifiers":3255},"10.1016\u002F0015-6264(81)90358-8",{"doi":3254},{"id":28,"text":3257,"url":28,"identifiers":3258},"10.1111\u002Fj.1365-2133.1984.tb15590.x",{"doi":3257},{"id":28,"text":3260,"url":28,"identifiers":3261},"10.1016\u002F0272-0590(86)90094-1",{"doi":3260},{"id":28,"text":3263,"url":28,"identifiers":3264},"10.1080\u002F15287394.2011.534425",{"doi":3263},{"id":28,"text":3266,"url":28,"identifiers":3267},"10.1093\u002Ftoxsci\u002F58.1.15",{"doi":3266},{"id":28,"text":3269,"url":28,"identifiers":3270},"SCCNFP.2006.Basic Criteria for The In Vitro Assessment of Dermal Absorption of Cosmetic Ingredients. Scientific Committee on Cosmetic Products and Non‐food Products Intended for Consumers (SCCNFP\u002F0970\u002F06) adopted by the SCCP during the 7th plenary meeting of 28 March 2006.",{},{"id":28,"text":3272,"url":28,"identifiers":3273},"10.1159\u002F000210952",{"doi":3272},{"id":28,"text":3275,"url":28,"identifiers":3276},"10.1159\u002F000029812",{"doi":3275},{"id":28,"text":3278,"url":28,"identifiers":3279},"10.1159\u002F000029928",{"doi":3278},{"id":28,"text":3281,"url":28,"identifiers":3282},"Sueki H, 2000, Hairless guinea pig skin: anatomical basis for studies of cutaneous biology, Eur. J. Dermatol., 10, 357",{},{"id":28,"text":3284,"url":28,"identifiers":3285},"Surber C, 1993, In vivo percutaneous absorption of [14C] acitretin in the hairless guinea pig and in the rhesus monkey, Arzneimittelforschung, 43, 1001",{},{"id":28,"text":3287,"url":28,"identifiers":3288},"10.1016\u002Fj.ijpharm.2005.05.030",{"doi":3287},{"id":28,"text":3290,"url":28,"identifiers":3291},"ThongsinthusakT RossJ MeindersD.1993.Guidance for The Preparation of Human Pesticide Exposure Assessment Documents. Report No. HS‐1612. Workers Health & Safety Branch Department of Pesticide Regulation California Environmental Protection Agency Sacramento CA.",{},{"id":28,"text":3293,"url":28,"identifiers":3294},"U.S. Environmental Protection Agency.1992.Dermal Exposure Assessment: Principles and Applications. EPA\u002F600\u002F8‐91\u002F011B. U.S. EPA Office of Health and Environmental Assessment Washington DC.",{},{"id":28,"text":3296,"url":28,"identifiers":3297},"USEPA, 2004, In vitro dermal absorption rate testing of certain chemicals of interest to the occupational safety and health administration; final rule, Fed. Regist., 69, 22402",{},{"id":28,"text":3299,"url":28,"identifiers":3300},"10.1007\u002Fs10047-003-0229-5",{"doi":3299},{"id":28,"text":3302,"url":28,"identifiers":3303},"10.1111\u002F1523-1747.ep12664543",{"doi":3302},{"id":28,"text":3305,"url":28,"identifiers":3306},"10.1080\u002F009841096161681",{"doi":3305},{"id":28,"text":3308,"url":28,"identifiers":3309},"10.1006\u002Ftaap.1998.8434",{"doi":3308},{"id":28,"text":3311,"url":28,"identifiers":3312},"10.1007\u002FBF00403844",{"doi":3311},{"id":28,"text":3314,"url":28,"identifiers":3315},"10.3109\u002F00498259209049904",{"doi":3314},{"id":28,"text":3317,"url":28,"identifiers":3318},"World Health Organization, International Programme on Chemical Safety, 2005, Dermal Absorption. Environmental Health Criteria 235",{},{"id":28,"text":3320,"url":28,"identifiers":3321},"10.1202\u002F0002-8894(2000)061\u003C0473:DAOPIT>2.0.CO;2",{"doi":3320},{"id":3323,"createTime":3324,"updateTime":3324,"relativeEntities":3325,"slug":3326,"properties":3327,"entityType":959,"verifyStatus":26,"verifyTime":3324,"verifyNote":960,"languages":3340,"translateLanguages":28,"viewCount":32,"primaryUrl":3341,"fullTextUrl":28,"authors":3342,"publicationType":996,"publisherRelationship":3377,"citationCount":437,"citationInfo":3422,"publishDate":3425,"publishYear":3423,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":3426,"openAccess":28,"references":3427,"isForceReanalyzing":1565},"25a1645e-6f93-4a8e-abd9-7ac25067aebb","2024-08-31T21:11:03.173+00:00",[],"Prevention-by-silymarin-of-membrane-alterations-in-acute-CCI-sub-4-sub-liver-damage",{"openalex":3328,"mag":3330,"abstract":3332,"title":3334,"pm":3336,"doi":3338},{"VOID":3329},"W2076708571",{"VOID":3331},"2076708571",{"EN":3333},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>The effect of silymarin on liver lipid peroxidation and membrane lipid alterations induced by an acute dose of CCI\u003Cjats:sub>4\u003C\u002Fjats:sub> was studied. Four groups of animals were treated with CCI\u003Cjats:sub>4\u003C\u002Fjats:sub>, CCI\u003Cjats:sub>4\u003C\u002Fjats:sub> + silymarin, silymarin and its vehicles. CCI\u003Cjats:sub>4\u003C\u002Fjats:sub> was given orally (0.4 g 100 g\u003Cjats:sup>−1\u003C\u002Fjats:sup> body wt.) and silymarin was administered i.p. All animals were sacrificed 24 h after the treatments. Liver lipid peroxidation was measured and plasma membranes were isolated. Alkaline phosphatase (AP) and gamma‐glutamyl transpeptidase (GGTP) were measured in plasma membranes. Membrane lipids were extracted and then analysed by thin‐layer chromatography by measuring the phosphorus of the phospholipids in each spot. Liver lipid peroxidation was increased about three times in the group receiving CCI\u003Cjats:sub>4\u003C\u002Fjats:sub> only. Silymarin cotreatment prevented this increase. Phosphatidylethanolamine (PEA) decreased, while phosphatidylinositol (PI) increased in the plasma membranes isolated from the CCI\u003Cjats:sub>4\u003C\u002Fjats:sub>‐treated group. Animals that received CCI\u003Cjats:sub>4\u003C\u002Fjats:sub> + silymarin showed no decrease in PEA content. A partial prevention of the decrease in phosphatidylinositol content was also observed in plasma membranes of animals treated with silymarin in addition to CCI\u003Cjats:sub>4\u003C\u002Fjats:sub>. CCI\u003Cjats:sub>4\u003C\u002Fjats:sub> decreased gamma‐glutamyl transpeptidase (GGTP) and alkaline phosphatase (AP) membrane activities. Silymarin cotreatment prevented the AP (completely) and the GGTP (partially) falls caused by CCI\u003Cjats:sub>4\u003C\u002Fjats:sub>. Silymarin by itself increased AP membrane activity.\u003C\u002Fjats:p>\u003Cjats:p>A significant relationship between the membrane content of phosphatidylethanolamine (PEA) and the AP activity was observed in plasma membranes of treated animals and in normal liver membranes enriched with PEA. These results indicate that silymarin can protect against the alterations induced by CCI\u003Cjats:sub>4\u003C\u002Fjats:sub> on the liver plasma membrane through its antioxidant properties by modifying the plasma membrane phospholipid content.\u003C\u002Fjats:p>",{"EN":3335},"Prevention by silymarin of membrane alterations in acute CCI\u003Csub>4\u003C\u002Fsub> liver damage",{"VOID":3337},"1975258",{"VOID":3339},"10.1002\u002Fjat.2550100408",[31],"https:\u002F\u002Fanalyticalsciencejournals.onlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fjat.2550100408",[3343,3362],{"id":3344,"sortIndex":32,"researcher":28,"roles":3345,"affiliations":3346,"properties":3355,"displayName":3359,"givenName":28,"familyName":28},"9ca05fbb-7a04-4baf-9087-031976626fff",[],[3347],{"id":3348,"sortIndex":32,"affiliation":3349,"properties":28},"3b0db5fb-4e42-4cd8-8f77-6df49e4ef9da",{"id":3348,"createTime":28,"updateTime":28,"relativeEntities":3350,"slug":28,"properties":3351,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3354,"statistic":28},[],{"title":3352},{"EN":3353},"Departamento de Farmacologia y Toxicologia. Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Apartado Postal 14–740, 07000 Mexico, D.F",[],{"orcid":3356,"title":3358,"openalex":3360},{"VOID":3357},"https:\u002F\u002Forcid.org\u002F0000-0002-2236-6631",{"EN":3359},"Pablo Muriel",{"VOID":3361},"A5016087971",{"id":3363,"sortIndex":40,"researcher":28,"roles":3364,"affiliations":3365,"properties":3372,"displayName":3374,"givenName":28,"familyName":28},"0e43c988-1b0c-47ab-88de-d272b114daf6",[],[3366],{"id":3348,"sortIndex":32,"affiliation":3367,"properties":28},{"id":3348,"createTime":28,"updateTime":28,"relativeEntities":3368,"slug":28,"properties":3369,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3371,"statistic":28},[],{"title":3370},{"EN":3353},[],{"title":3373,"openalex":3375},{"EN":3374},"Marisabel Mourelle",{"VOID":3376},"A5082607636",{"url":28,"publisher":3378,"properties":3416},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":3379,"slug":872,"properties":3380,"entityType":25,"verifyStatus":884,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":3385,"manageAffiliations":3390,"indexDatabases":3401,"url":936,"thumbnailPath":28,"statistic":28,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"country":3381,"eissn":3382,"issn":3383,"title":3384},{"VOID":875},{"VOID":877},{"VOID":879},{"EN":881},[3386],{"id":887,"createTime":28,"updateTime":28,"relativeEntities":3387,"label":3388,"description":3389,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},[3391,3396],{"id":894,"createTime":28,"updateTime":28,"relativeEntities":3392,"slug":28,"properties":3393,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3395,"statistic":28},[],{"title":3394},{"EN":898},[],{"id":901,"createTime":28,"updateTime":28,"relativeEntities":3397,"slug":28,"properties":3398,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3400,"statistic":28},[],{"title":3399},{"EN":905},[],[3402,3409],{"id":909,"indexDatabase":3403,"url":915,"indexYears":916,"academicFieldIds":3408,"indexDatabaseRanking":919},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":3404,"label":3405,"description":3406,"key":781,"publicationTags":3407,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[918],{"id":921,"indexDatabase":3410,"url":933,"indexYears":28,"academicFieldIds":3415,"indexDatabaseRanking":28},{"id":923,"createTime":28,"updateTime":28,"relativeEntities":3411,"label":3412,"description":3413,"key":930,"publicationTags":3414,"standard":28},[],{"EN":926,"VI":926},{"EN":928,"VI":929},[932,813],[935],{"issue":3417,"pages":3418,"volume":3420},{"VOID":1038},{"VOID":3419},"275-279",{"VOID":3421},"10",{"total":437,"publishYear":3423,"statisticByYear":3424},1990,{"2012":146,"2013":357,"2014":47,"2015":47,"2016":47,"2017":49,"2018":46,"2019":46,"2020":49,"2021":46,"2022":45,"2023":46,"2024":48},"1990-08-01",[919,932],[3428,3431,3434,3437,3440,3443,3446,3449,3452,3455,3458,3461,3464,3467,3470,3473,3476,3479,3482,3485,3488,3491,3494,3497,3500,3503,3506,3509,3512],{"id":28,"text":3429,"url":28,"identifiers":3430},"McLean A. E. M., 1965, Cellular necrosis in the liver induced and modified by drugs, Int. Rev. Exp. 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The motivation of the present study was (1) to analyze the effect of silver particle size on rat tissue distribution at different time points, (2) to determine the accumulation of AgNPs in potential rat target organs, (3) to analyze the intracellular distribution of AgNPs and (4) to examine the excretion of AgNPs by urine and feces. AgNPs were characterized by dynamic light scattering (DLS), zeta potential measurements, BET surface area measurements, transmission and scanning electron microscopy. AgNPs (20 and 200 nm) were administered intravenously (i.v.) to male Wistar rats at a dose of 5 mg kg\u003Cjats:sup>–1\u003C\u002Fjats:sup> of body weight. Biological material was sampled 24 h, 7 and 28 days after injection. Using inductively coupled plasma‐mass spectrometry (ICP‐MS) and transmission electron microscopy (TEM) it was observed that AgNPs translocated from the blood to the main organs and the concentration of silver in tissues was significantly higher in rats treated with 20 nm AgNPs as compared with 200 nm AgNPs. The highest concentration of silver was found in the liver after 24 h. After 7 days, a high level of silver was observed in the lungs and spleen. The silver concentration in the kidneys and brain increased during the experiment and reached the highest concentration after 28 days. Moreover, the highest concentration of AgNPs was observed in the urine 1 day after the injection, maintained high for 14 days and then decreased. The fecal level of silver in rats was the highest within 2 days after AgNPs administration and then decreased. Copyright © 2012 John Wiley & Sons, Ltd.\u003C\u002Fjats:p>","\u003Ctên_tóm_tắt> TÓM TẮT \u003C\u002Ftên_tóm_tắt>\u003Cđoạn_văn> Hạt nano bạc (AgNPs) là loại hạt nano được sử dụng phổ biến nhất nhờ tính chất kháng khuẩn của chúng. Động lực của nghiên cứu này là (1) phân tích ảnh hưởng của kích thước hạt bạc đến sự phân bố tại các mô của chuột ở các thời điểm khác nhau, (2) xác định sự tích tụ của AgNPs trong các cơ quan mục tiêu tiềm năng của chuột, (3) phân tích phân bố nội bào của AgNPs và (4) kiểm tra sự thải trừ của AgNPs qua nước tiểu và phân. AgNPs được đặc trưng bằng phương pháp tán xạ ánh sáng động (DLS), đo thế zeta, đo diện tích bề mặt BET, kính hiển vi điện tử truyền qua và quét. AgNPs (20 và 200 nm) được tiêm tĩnh mạch (i.v.) cho chuột Wistar đực với liều 5 mg kg\u003Cjats:sup>–1\u003C\u002Fjats:sup> trọng lượng cơ thể. Vật liệu sinh học được lấy mẫu sau 24 giờ, 7 và 28 ngày sau khi tiêm. Sử dụng phương pháp khối phổ plasma cảm ứng (ICP‐MS) và kính hiển vi điện tử truyền qua (TEM), người ta quan sát thấy rằng AgNPs dịch chuyển từ máu đến các cơ quan chính và nồng độ bạc trong mô cao hơn đáng kể ở chuột được điều trị bằng AgNPs 20 nm so với AgNPs 200 nm. Nồng độ bạc cao nhất được tìm thấy trong gan sau 24 giờ. Sau 7 ngày, mức độ bạc cao đã được quan sát trong phổi và lá lách. Nồng độ bạc trong thận và não tăng lên trong suốt thí nghiệm và đạt nồng độ cao nhất sau 28 ngày. Hơn nữa, nồng độ AgNPs cao nhất được quan sát thấy trong nước tiểu sau 1 ngày kể từ khi tiêm, duy trì cao trong 14 ngày và sau đó giảm. Mức độ bạc trong phân của chuột cao nhất trong vòng 2 ngày sau khi tiêm AgNPs và sau đó giảm. Bản quyền © 2012 John Wiley & Sons, Ltd. \u003C\u002Fđoạn_văn>",{"EN":3532,"VI":3533},"Time‐dependent biodistribution and excretion of silver nanoparticles in male Wistar rats","Phân phối sinh học và thải trừ của hạt nano bạc phụ thuộc vào thời gian ở chuột Wistar 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Generally, riot control agents can produce acute site‐specific toxicity where sensory irritation occurs. Early riot control agents, namely, chloroacetophenone (CN) and chlorodihydrophenarsazine (DM), have been replaced with ‘safer’ agents such as \u003Cjats:italic>o\u003C\u002Fjats:italic>‐chlorobenzylidene malononitrile (CS) and oleoresin of capsicum (OC). Riot control agents are safe when used as intended: however, the widespread use of riot control agents raises questions and concerns regarding their health effects and safety. A large margin exists between dosages that produce harassment and dosages likely to cause adverse health effects for modern riot control agents such as CS and dibenz[\u003Cjats:italic>b\u003C\u002Fjats:italic>,\u003Cjats:italic>f\u003C\u002Fjats:italic>]1 : 4‐oxazepine (CR). Yet, despite the low toxicity of modern riot control agents, these compounds are not entirely without risk. The risk of toxicity increases with higher exposure levels and prolonged exposure durations. Ocular, pulmonary and dermal injury may occur on exposure to high levels of these substances, and exposure to riot control agents in enclosed spaces may produce significant toxic effects. Reported deaths are few involving riot control agents, and then only under conditions of prolonged exposure and high concentrations. Recently, concern has focused on the deaths resulting from law enforcement use of OC, a riot control agent generally regarded as safe because it is a natural product. As with other xenobiotics, not enough is known concerning the long‐term\u002Fchronic effects of riot control agents. Clearly, there is considerable need for additional research to define and delineate the biological and toxicological actions of riot control agents and to illuminate the full health consequences of these compounds as riot control agents. 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