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The geometry of the model was based on magnetic resonance images of the skull of a healthy male subject. Pressure measurements, flow visualization, and hot-wire anemometry studies were performed at flow rates that, in vivo, corresponded to flows of between 0.05 and 1.50 l\u002Fs. The influence of nasal congestion and the collapse of the external nares were examined by using modeling clay to simulate local constrictions in the cross section. A dimensionless analysis of the pressure losses within three sections of the airway revealed the influence of various anatomic dimensions on nasal resistance. The region of the exterior nose behaves as a contraction-expansion nozzle in which the pressure losses are a function of the smallest cross-sectional area. Losses in the interior nose resemble those associated with channel flow. The nasopharynx is modeled as a sharp bend in a circular duct. 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Van Lunteren, Erik, and Michelle Moyer. Effects of DAP on diaphragm force and fatigue, including fatigue due to neurotransmission failure. J. Appl. Physiol. 81(5): 2214–2220, 1996.—Among the aminopyridines, 3,4-diaminopyridine (DAP) is a more effective K\u003Cjats:sup>+\u003C\u002Fjats:sup> channel blocker than is 4-aminopyridine (4-AP), and, furthermore, DAP enhances neuromuscular transmission. Because 4-AP improves muscle contractility, we hypothesized that DAP would also increase force and, in addition, ameliorate fatigue and improve the neurotransmission failure component of fatigue. Rat diaphragm strips were studied in vitro (37°C). In field-stimulated muscle, 0.3 mM DAP significantly increased diaphragm twitch force, prolonged contraction time, and shifted the force-frequency relationship to the left without altering peak tetanic force, resulting in increased force at stimulation frequencies ≤50 Hz. During 20-Hz intermittent stimulation, DAP increased diaphragm peak force compared with control during a 150-s fatigue run and, furthermore, significantly improved maintenance of intratrain force. The relative contribution of neurotransmission failure to fatigue was estimated by comparing the force generated by phrenic nerve-stimulated muscles with that generated by curare-treated field-stimulated muscles. DAP significantly increased force in nerve-stimulated muscles and, in addition, reduced the neurotransmission failure contribution to diaphragm fatigue. 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Experiments were conducted in unanesthetized, chronically catheterized pregnant sheep to determine the fetal behavioral response to prolonged hypoxemia produced by restricting uterine blood flow. 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Human skin blood flow is controlled via dual innervation from the sympathetic nervous system. Reflex cutaneous vasoconstriction and vasodilation are both impaired with primary aging, rendering the aged more vulnerable to hypothermia and cardiovascular complications from heat-related illness. Age-related alterations in the thermoregulatory control of skin blood flow occur at multiple points along the efferent arm of the reflex, including 1) diminished sympathetic outflow, 2) altered presynaptic neurotransmitter synthesis, 3) reduced vascular responsiveness, and 4) impairments in downstream (endothelial and vascular smooth muscle) second-messenger signaling. This mechanistic review highlights some of the recent findings in the area of aging and the thermoregulatory control of skin blood flow. \u003C\u002Fjats:p>","\u003Cjats:p> Lưu lượng máu ở da người được kiểm soát thông qua sự chi phối kép từ hệ thần kinh giao cảm. 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Appl. Physiol. 67: 453–465, 1989). This model relates the average power output available over a given running time for a given combination of anaerobic capacity, maximal aerobic power, and endurance capability. For short sprinting distances, the contribution of aerobic metabolism to the energy requirement is small and the speed sustained is high. The reduction of maximal aerobic power with altitude is, thus, negligible, whereas the reduction of aerodynamic resistance is beneficial. Accordingly the performance steadily increases with altitude (e.g., average speed for 100 m at Mexico City is 101.9% of the average speed at sea level). On the other hand, the reduction in maximal aerobic power with altitude is associated with a reduction in performance over middle and long distances (800 m to marathon). For 400 m an improvement in performance is observed up to an altitude of approximately 2,400–2,500 m (average speed approximately 101.4% of sea level speed). Beyond this altitude the reduction in air density cannot compensate for the reduction in maximal aerobic power, and the performance deteriorates. 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Suspensions of human red cells in citrated plasma, in Ringer solution, and in Ringer solution containing albumin were passed through straight and curved glass and plastic hollow fibers (diameter range, 100–1,000 μ). Pressure-flow relations were measured over the pressure range of 0.1– 800 mm water, corresponding to a shear stress range of 0.01– 80 dynes\u002Fcm2. The suspensions were tested simultaneously in a rotational viscometer. It was found that red cell suspensions exhibit a yield shear stress only if the plasma protein fibrinogen is present. Experimental pressure-flow data in hollow fibers were in excellent agreement with rotational viscometer measurements and with analytical predictions based on the assumptions that blood flows as a homogeneous continuum and that the velocity at the wall is zero. Effects of tube surface characteristics and curvature on the pressure drop-flow rate relation were not discernible. \u003C\u002Fjats:p>\u003Cjats:p> microcirculation models; model blood flow; yield stress of blood; capillary blood flow and viscometry; fibrinogen and blood flow in hollow fibers; non-Newtonian flow of blood in hollow fibers \u003C\u002Fjats:p>\u003Cjats:p> Submitted on July 20, 1964 \u003C\u002Fjats:p>",{"EN":1533},"Pressure-flow relations of human blood in hollow fibers at low flow rates",{"VOID":1535},"5837623",{"VOID":1537},"10.1152\u002Fjappl.1965.20.5.954",[293],"https:\u002F\u002Fwww.physiology.org\u002Fdoi\u002F10.1152\u002Fjappl.1965.20.5.954",[1541,1558,1573,1588,1603],{"id":1542,"sortIndex":25,"researcher":24,"roles":1543,"affiliations":1544,"properties":1553,"displayName":1555,"givenName":24,"familyName":24},"5070b9ab-f852-4f4e-b5dc-5027a84b6bb9",[],[1545],{"id":1546,"sortIndex":25,"affiliation":1547,"properties":24},"8dc29336-9674-46ba-bf05-bdac310d0a1e",{"id":1546,"createTime":24,"updateTime":24,"relativeEntities":1548,"slug":24,"properties":1549,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1552,"statistic":24},[],{"title":1550},{"EN":1551},"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, and Surgical Services, Massachusetts General Hospital, Boston, Massachusetts",[],{"title":1554,"openalex":1556},{"EN":1555},"Edward W. 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The role of neuromuscular activity in maintaining the normal enzyme heterogeneity found in a predominantly fast mixed muscle was studied. Enzymatic profiles of single fibers in the adult cat medial gastrocnemius (MG) were examined after almost complete elimination of neuromuscular activity for 6 mo. Inactivity was achieved by spinal cord isolation (SI), i.e., spinal transection at T12-T13 and L7-S1 combined with bilateral dorsal rhizotomy between the two transection sites. Cross-sectional area and succinate dehydrogenase (SDH) and alpha-glycerophosphate dehydrogenase (GPD) activities were determined in a population of fibers identified in frozen serial cross sections. Each fiber was categorized as light or dark on the basis of its staining characteristics for qualitative myosin adenosinetriphosphatase (ATPase), alkaline preincubation, and its reaction to fast and slow myosin heavy chain (MHC) antibodies. SI resulted in a conversion of nearly all light (approximately 36% in the control) to dark ATPase fibers. Virtually all MG fibers in the SI cats reacted with the fast MHC antibody, whereas very few fibers reacted with slow MHC antibody. On the basis of fiber cross-sectional area, it was estimated that the MG atrophied by approximately 10% after SI. Compared with the mean of the dark and light ATPase fibers in control (weighted by the percent fiber type distribution), mean SDH activity was significantly lower (approximately 70%) and mean GPD activity was significantly higher (approximately 120%) in the SI cats. 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