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other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. 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And the first issue was published in January 1998 with ISSN 1859-0128. Since then, STDJ has become the most important scientific forum of scientists from VNU-HCM as well as other universities. The magazine has undergone 20 years of development and has become a bridge for scientific exchanges, as well as enriching reference materials for the faculty, doctoral students, students of VNU-HCM in particular and other universities, institutes...\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Science and Technology Development Journal - Health Sciences (STDJ-HS) is a subjournal of Science and Technology Development Journal since 2020.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\" \"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"2. 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Sự gia tăng CO2 xảy ra khi lactate tăng lên trong quá trình tập thể dục bởi vì [H+] của nó chủ yếu được đệm bằng HCO-3 (22 ml cho mỗi meq axit lactic). Chúng tôi đã phát triển một phương pháp để phát hiện ngưỡng hiếu khí (AT), sử dụng phân tích hồi quy máy tính của các độ dốc của đồ thị CO2 thu nhận (VCO2) so với O2 thu nhận (VO2), phương pháp này phát hiện sự bắt đầu của việc phát thải CO2 dư thừa được tạo ra từ việc đệm của [H+], được gọi là phương pháp V-slope. Từ các bài kiểm tra thể dục gia tăng trên 10 đối tượng, điểm phát thải CO2 dư thừa (AT) dự đoán gần như chính xác ngưỡng lactate và HCO-3. Giá trị trao đổi khí trung bình AT được tìm thấy tương ứng với một sự gia tăng nhỏ của lactate trên ngưỡng lactate được xác định bằng toán học [0.50 +\u002F- 0.34 (SD) meq\u002Fl] và không khác biệt đáng kể so với ngưỡng HCO-3 ước tính. Giá trị trung bình VO2 tại AT tính toán bằng phân tích V-slope không khác biệt đáng kể so với giá trị trung bình được xác định bởi một ban hội thẩm gồm sáu đánh giá viên có kinh nghiệm sử dụng các phương pháp hình thức truyền thống, nhưng AT có thể được xác định một cách đáng tin cậy hơn bằng phương pháp V-slope. Điểm bù đắp hô hấp, được phát hiện riêng biệt bằng cách kiểm tra đồ thị thông khí phút so với VCO2, thường cao hơn AT (2.51 +\u002F- 0.42 so với 1.83 +\u002F- 0.30 l\u002Fphút VO2). Phương pháp này để xác định AT có những lợi thế đáng kể so với các phương pháp khác phụ thuộc vào mẫu nhịp thở đều và tính nhạy cảm hóa học của hô hấp.\u003C\u002Fjats:p>","\u003Cjats:p> Excess CO2 is generated when lactate is increased during exercise because its [H+] is buffered primarily by HCO-3 (22 ml for each meq of lactic acid). We developed a method to detect the anaerobic threshold (AT), using computerized regression analysis of the slopes of the CO2 uptake (VCO2) vs. O2 uptake (VO2) plot, which detects the beginning of the excess CO2 output generated from the buffering of [H+], termed the V-slope method. From incremental exercise tests on 10 subjects, the point of excess CO2 output (AT) predicted closely the lactate and HCO-3 thresholds. The mean gas exchange AT was found to correspond to a small increment of lactate above the mathematically defined lactate threshold [0.50 +\u002F- 0.34 (SD) meq\u002Fl] and not to differ significantly from the estimated HCO-3 threshold. The mean VO2 at AT computed by the V-slope analysis did not differ significantly from the mean value determined by a panel of six experienced reviewers using traditional visual methods, but the AT could be more reliably determined by the V-slope method. The respiratory compensation point, detected separately by examining the minute ventilation vs. VCO2 plot, was consistently higher than the AT (2.51 +\u002F- 0.42 vs. 1.83 +\u002F- 0.30 l\u002Fmin of VO2). This method for determining the AT has significant advantages over others that depend on regular breathing pattern and respiratory chemosensitivity. \u003C\u002Fjats:p>",{"VI":1006,"EN":1007},"Một phương pháp mới để phát hiện ngưỡng hiếu khí bằng cách trao đổi khí","A new method for detecting anaerobic threshold by gas exchange",{"VOID":1009},"3087938",{"VOID":1011},"10.1152\u002Fjappl.1986.60.6.2020",[102],[101],"https:\u002F\u002Fwww.physiology.org\u002Fdoi\u002F10.1152\u002Fjappl.1986.60.6.2020",[1016,1025,1034],{"id":1017,"sortIndex":115,"researcher":26,"roles":1018,"affiliations":1019,"properties":1020},"db6dede7-69ce-4af1-aab5-6db44253e73b",[],[],{"openalex":1021,"title":1023},{"VOID":1022},"A5026318171",{"EN":1024},"K. 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Nam giới có khối lượng SM đáng kể (P \u003C 0.001) nhiều hơn so với nữ giới, cả trong các số tuyệt đối (33.0 so với 21.0 kg) và tỷ lệ so với khối lượng cơ thể (38.4 so với 30.6%). Sự khác biệt về giới tính rõ rệt hơn ở phần trên của cơ thể (40%) so với phần dưới (33%) (P \u003C 0.01). Chúng tôi quan sát thấy sự giảm sút trong khối lượng SM tỷ lệ bắt đầu từ thập kỷ thứ ba; tuy nhiên, sự giảm sút rõ rệt trong khối lượng SM tuyệt đối chỉ được ghi nhận cho đến cuối thập kỷ thứ năm. Sự giảm sút này chủ yếu do sự sụt giảm trong khối lượng SM ở phần dưới cơ thể. Cân nặng và chiều cao giải thích khoảng 50% sự thay đổi trong khối lượng SM ở cả nam và nữ. Mặc dù có một mối quan hệ tuyến tính giữa SM và chiều cao, nhưng mối quan hệ giữa SM và cân nặng là phi tuyến vì đóng góp của SM vào tăng cân giảm dần khi cân nặng tăng lên. Những phát hiện này chỉ ra rằng nam giới có nhiều SM hơn nữ giới và rằng những khác biệt về giới tính này lớn hơn ở phần trên cơ thể. Độc lập với giới tính, quá trình lão hóa liên quan đến sự giảm khối lượng SM, điều này phần lớn được giải thích bởi sự giảm phát triển của SM ở phần dưới cơ thể xảy ra sau thập kỷ thứ năm.\u003C\u002Fjats:p>","\u003Cjats:p> We employed a whole body magnetic resonance imaging protocol to examine the influence of age, gender, body weight, and height on skeletal muscle (SM) mass and distribution in a large and heterogeneous sample of 468 men and women. Men had significantly ( P < 0.001) more SM in comparison to women in both absolute terms (33.0 vs. 21.0 kg) and relative to body mass (38.4 vs. 30.6%). The gender differences were greater in the upper (40%) than lower (33%) body ( P < 0.01). We observed a reduction in relative SM mass starting in the third decade; however, a noticeable decrease in absolute SM mass was not observed until the end of the fifth decade. This decrease was primarily attributed to a decrease in lower body SM. Weight and height explained ∼50% of the variance in SM mass in men and women. Although a linear relationship existed between SM and height, the relationship between SM and body weight was curvilinear because the contribution of SM to weight gain decreased with increasing body weight. These findings indicate that men have more SM than women and that these gender differences are greater in the upper body. Independent of gender, aging is associated with a decrease in SM mass that is explained, in large measure, by a decrease in lower body SM occurring after the fifth decade. \u003C\u002Fjats:p>",{"VI":1199,"EN":1200},"Khối lượng và phân bố cơ vân ở 468 nam và nữ có độ tuổi từ 18–88","Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr",{"VOID":1202},"10904038",{"VOID":1204},"10.1152\u002Fjappl.2000.89.1.81","Auto Verify",[102],[101],"https:\u002F\u002Fwww.physiology.org\u002Fdoi\u002F10.1152\u002Fjappl.2000.89.1.81",[1210,1231,1248,1267],{"id":1211,"sortIndex":59,"researcher":26,"roles":1212,"affiliations":1213,"properties":1224},"388c25bd-1b1a-4fdd-9e5a-cce46bb41edf",[],[1214],{"id":1215,"sortIndex":36,"affiliation":1216,"properties":26},"b682e5a1-ae6f-4c7e-bdbb-2e872c976b56",{"id":1217,"createTime":1218,"updateTime":1218,"relativeEntities":1219,"slug":1220,"properties":1221,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"b129896a-6114-4b01-99a6-5dd61c480308","2024-11-25T05:11:39.102+00:00",[],"School-of-Physical-and-Health-Education-Queen-s-University-Kingston-Ontario-Canada-K7L-3N6-and",{"title":1222},{"EN":1223},"School of Physical and Health Education, Queen's University, Kingston, Ontario, Canada K7L 3N6; and",{"openalex":1225,"orcid":1227,"title":1229},{"VOID":1226},"A5035023003",{"VOID":1228},"https:\u002F\u002Forcid.org\u002F0000-0001-6875-785X",{"EN":1230},"Robert Ross",{"id":1232,"sortIndex":36,"researcher":26,"roles":1233,"affiliations":1234,"properties":1241},"bf047a83-6746-4b81-9f57-520b131b7e02",[],[1235],{"id":1236,"sortIndex":36,"affiliation":1237,"properties":26},"bcf96fe2-009f-4d0a-ac7f-3745428b0d8a",{"id":1217,"createTime":1218,"updateTime":1218,"relativeEntities":1238,"slug":1220,"properties":1239,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1240},{"EN":1223},{"openalex":1242,"orcid":1244,"title":1246},{"VOID":1243},"A5009123832",{"VOID":1245},"https:\u002F\u002Forcid.org\u002F0000-0003-2159-3012",{"EN":1247},"Ian Janssen",{"id":1249,"sortIndex":114,"researcher":26,"roles":1250,"affiliations":1251,"properties":1262},"0f16d88a-d631-4693-8964-44d68642f4a7",[],[1252],{"id":1253,"sortIndex":36,"affiliation":1254,"properties":26},"663d6ef5-e5ab-43e9-ad3a-a2fab811f1bc",{"id":1255,"createTime":1256,"updateTime":1256,"relativeEntities":1257,"slug":1258,"properties":1259,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"b7195934-0595-408b-a9c0-073fa8a42cac","2024-11-25T05:11:39.116+00:00",[],"Obesity-Research-Center-St-Luke-s-Roosevelt-Hospital-Columbia-University-College-of-Physicians-and-Surgeons-New-York-New-York-10025",{"title":1260},{"EN":1261},"Obesity Research Center, St. Luke's\u002FRoosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, New York 10025",{"openalex":1263,"title":1265},{"VOID":1264},"A5031848788",{"EN":1266},"ZiMian Wang",{"id":1268,"sortIndex":115,"researcher":26,"roles":1269,"affiliations":1270,"properties":1277},"17f6d76f-c522-4e66-a611-c4e9e66aa7ea",[],[1271],{"id":1272,"sortIndex":36,"affiliation":1273,"properties":26},"35eb4e16-5e2f-466c-9d07-b5fb7690d8bf",{"id":1255,"createTime":1256,"updateTime":1256,"relativeEntities":1274,"slug":1258,"properties":1275,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1276},{"EN":1261},{"openalex":1278,"orcid":1280,"title":1282},{"VOID":1279},"A5065818595",{"VOID":1281},"https:\u002F\u002Forcid.org\u002F0000-0003-1127-9425",{"EN":1283},"Steven B. 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hóa carbohydrate, oxy hóa chất béo, quá trình trao đổi chất, lipogenesis, gluconeogenesis",{"VOID":1462},"W2131501155",{"VI":1464,"EN":1465},"\u003Cjats:p> Bài báo này xem xét các giả định liên quan đến việc tính toán tỷ lệ oxy hóa carbohydrate và chất béo từ các phép đo tiêu thụ O2, sản xuất CO2 và bài tiết nitơ qua nước tiểu. Kết quả sai lệch được chứng minh là có được khi xuất hiện các quá trình trao đổi chất như lipogenesis và gluconeogenesis. Tuy nhiên, các tỷ lệ dường như được tính toán dưới các điều kiện này có thể được hiểu là tỷ lệ \"sử dụng\" ròng. Do đó, tỷ lệ dường như của oxy hóa carbohydrate là tổng của các tỷ lệ sử dụng cho oxy hóa và cho lipogenesis trừ đi tỷ lệ mà carbohydrate được hình thành từ axit amin. Tỷ lệ dường như của oxy hóa chất béo là sự chênh lệch giữa các tỷ lệ oxy hóa và tổng hợp từ carbohydrate, do đó các tỷ lệ dường như âm được phát hiện ở bệnh nhân truyền glucose thực sự đại diện cho tỷ lệ tổng hợp ròng một cách định lượng. Các quá trình khác như tổng hợp các thể cetone hoặc lactate với tỷ lệ lớn hơn tỷ lệ sử dụng của chúng cũng có thể làm rối loạn các phép tính, nhưng quy mô của hiệu ứng có thể được ước lượng từ các phép đo phù hợp. Các phương pháp điều chỉnh sự trao đổi khí quan sát được trong các trường hợp này được đưa ra.","\u003Cjats:p> This paper reviews the assumptions involved in calculating rates of carbohydrate and fat oxidation from measurements of O2 consumption, CO2 production, and urinary nitrogen excretion. It is shown that erroneous results are obtained in the presence of metabolic processes such as lipogenesis and gluconeogenesis. The apparent rates calculated under these conditions can, however, be interpreted as net rates of “utilization.” Thus the apparent rate of carbohydrate oxidation is the sum of the rates of utilization for oxidation and for lipogenesis minus the rate at which carbohydrate is formed from amino acids. The apparent rate of fat oxidation is the difference between the rates of oxidation and synthesis from carbohydrate, so that the apparently negative rates encountered in patients infused with glucose do quantitatively represent net rates of synthesis. Other processes such as synthesis of ketone bodies or lactate at rates greater than their utilization can also disturb the calculations, but the magnitude of the effect can be estimated from appropriate measurements. Methods of correcting the observed gaseous exchange in these circumstances are given. \u003C\u002Fjats:p>",{"VI":1467,"EN":1468},"Tính toán tỷ lệ oxy hóa chất nền trong cơ thể sống từ sự trao đổi khí","Calculation of substrate oxidation rates in vivo from gaseous exchange",{"VOID":1470},"6618956",{"VOID":1472},"10.1152\u002Fjappl.1983.55.2.628",[102],[101],"https:\u002F\u002Fwww.physiology.org\u002Fdoi\u002F10.1152\u002Fjappl.1983.55.2.628",[1477],{"id":1478,"sortIndex":36,"researcher":26,"roles":1479,"affiliations":1480,"properties":1481},"8e44523a-8c1f-4ca4-ad5b-089f1e97237d",[],[],{"openalex":1482,"orcid":1484,"title":1486},{"VOID":1483},"A5054559312",{"VOID":1485},"https:\u002F\u002Forcid.org\u002F0000-0001-7281-1863",{"EN":1487},"Keith N. 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Những thích nghi này bao gồm sự gia tăng một phần nội bào ty thể và khả năng hô hấp của sợi cơ. Kết quả của việc gia tăng ty thể, bài tập với cường độ giống nhau dẫn đến một sự rối loạn trong cân bằng nội môi nhỏ hơn ở những cơ đã được tập luyện so với những cơ chưa được tập luyện. Các hậu quả chuyển hóa chính của những thích nghi của cơ bắp với bài tập sức bền là việc sử dụng glycogen cơ bắp và glucose trong máu diễn ra chậm hơn, phụ thuộc nhiều hơn vào quá trình oxi hoá mỡ và sản xuất lactate ít hơn trong suốt bài tập với một cường độ nhất định. Những thích nghi này đóng một vai trò quan trọng trong việc tăng cường khả năng thực hiện các bài tập nặng kéo dài, điều này xảy ra như là phản ứng đối với việc tập luyện sức bền.","\u003Cjats:p> Regularly performed endurance exercise induces major adaptations in skeletal muscle. These include increases in the mitochondrial content and respiratory capacity of the muscle fibers. As a consequence of the increase in mitochondria, exercise of the same intensity results in a disturbance in homeostasis that is smaller in trained than in untrained muscles. The major metabolic consequences of the adaptations of muscle to endurance exercise are a slower utilization of muscle glycogen and blood glucose, a greater reliance on fat oxidation, and less lactate production during exercise of a given intensity. 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độ da, trọng số, nhiệt độ bề mặt, cơ thể người, nghiên cứu y sinh",{"VOID":1759},"W1596457316",{"VI":1761,"EN":1762},"\u003Cjats:p> Dựa trên phân tích dữ liệu nhiệt độ da của ba đối tượng con người trong quá trình nghỉ ngơi từ 112 thí nghiệm, một hệ thống trọng số đơn giản để tính nhiệt độ da trung bình từ quan sát ở bốn vùng của cơ thể, cụ thể là ngực, tay, đùi và chân, đã được đề xuất. Hệ thống trọng số được đề xuất cho ra các giá trị nhiệt độ da trung bình tương đương với công thức trọng số phức tạp của Hardy-Dubois. Giá trị nhiệt độ đùi giữa như một chỉ số của nhiệt độ da trung bình cũng đã được nghiên cứu và thảo luận.\u003C\u002Fjats:p>\u003Cjats:p> Đo lường nhiệt độ da \u003C\u002Fjats:p>\u003Cjats:p> Nộp vào ngày 20 tháng 5 năm 1963 \u003C\u002Fjats:p>","\u003Cjats:p> On the basis of an analysis of the skin temperature data on three resting human subjects from 112 experiments, a simple weighting system for computing the mean skin temperature from observations on four areas of the body, namely, chest, arms, thighs, and legs, has been proposed. The proposed system of weighting yields mean skin temperature values identical with the elaborate Hardy-Dubois weighting formula. The value of the medial thigh temperature as an index of the mean skin temperature has also been investigated and discussed. \u003C\u002Fjats:p>\u003Cjats:p> skin temperature measurement \u003C\u002Fjats:p>\u003Cjats:p> Submitted on May 20, 1963 \u003C\u002Fjats:p>",{"VI":1764,"EN":1765},"Một hệ thống trọng số mới để tính nhiệt độ bề mặt trung bình của cơ thể người","A new weighting system for mean surface temperature of the human 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All-India Institute of Hygiene and Public Health Calcutta, India",{"openalex":1789,"title":1791},{"VOID":1790},"A5077648096",{"EN":1792},"Narayanan 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eletal-muscle-following-resistance-training",{"mag":1845,"keywords":1847,"openalex":1848,"abstract":1850,"title":1853,"pm":1856,"doi":1858},{"VOID":1846},"2116282778",{"VI":999},{"VOID":1849},"W2116282778",{"VI":1851,"EN":1852},"\u003Cjats:p>Tốc độ gia tăng tối đa của lực cơ [tốc độ phát triển lực (RFD)] có những hậu quả chức năng quan trọng vì nó xác định lực mà có thể được tạo ra trong giai đoạn đầu của co cơ (0–200 ms). Nghiên cứu hiện tại đã xem xét tác động của việc tập luyện kháng lực lên RFD co cơ và dòng ra thần kinh (\"tín hiệu thần kinh\") trong quá trình co cơ tối đa. RFD co cơ (độ dốc của đường cong lực-thời gian), xung lực (lực tích hợp theo thời gian), biên độ tín hiệu điện cơ (EMG) (điện áp trung bình) và tỷ lệ gia tăng EMG (độ dốc của đường cong EMG-thời gian) đã được xác định (tần số lấy mẫu 1-kHz) trong quá trình co cơ tĩnh tối đa (cơ tứ đầu đùi) ở 15 đối tượng nam trước và sau 14 tuần tập luyện sức mạnh kháng lực nặng (38 buổi). Lực cơ tối đa tĩnh [co cơ tự nguyện tối đa (MVC)] đã tăng từ 291.1 ± 9.8 đến 339.0 ± 10.2 N · m sau khi tập luyện. RFD co cơ xác định trong các khoảng thời gian 30, 50, 100 và 200 ms tính từ lúc bắt đầu co cơ đã tăng từ 1,601 ± 117 đến 2,020 ± 119 (P \u003C 0.05), 1,802 ± 121 đến 2,201 ± 106 (P \u003C 0.01), 1,543 ± 83 đến 1,806 ± 69 (P \u003C 0.01), và 1,141 ± 45 đến 1,363 ± 44 N · m · s\u003Cjats:sup>−1\u003C\u002Fjats:sup> (P \u003C 0.01), tương ứng. Các tăng tương ứng cũng được quan sát thấy trong xung lực co cơ (P \u003C 0.01–0.05). Khi chuẩn hóa so với MVC, RFD co cơ đã tăng 15% sau khi tập luyện (tại không đến một phần sáu MVC; P \u003C 0.05). Hơn nữa, EMG của cơ tăng (P \u003C 0.01–0.05) từ 22–143% (điện áp trung bình) và 41–106% (tỷ lệ gia tăng EMG) trong giai đoạn co cơ sớm (0–200 ms). Tóm lại, sự gia tăng sức mạnh cơ bắp bùng nổ (RFD và xung lực co cơ) đã được quan sát sau khi tập luyện sức mạnh kháng lực nặng. Những phát hiện này có thể được giải thích bằng sự cải thiện dẫn truyền thần kinh, như được chứng minh bởi sự gia tăng đáng kể về biên độ tín hiệu EMG và tỷ lệ gia tăng EMG trong giai đoạn đầu của co cơ.","\u003Cjats:p>The maximal rate of rise in muscle force [rate of force development (RFD)] has important functional consequences as it determines the force that can be generated in the early phase of muscle contraction (0–200 ms). The present study examined the effect of resistance training on contractile RFD and efferent motor outflow (“neural drive”) during maximal muscle contraction. Contractile RFD (slope of force-time curve), impulse (time-integrated force), electromyography (EMG) signal amplitude (mean average voltage), and rate of EMG rise (slope of EMG-time curve) were determined (1-kHz sampling rate) during maximal isometric muscle contraction (quadriceps femoris) in 15 male subjects before and after 14 wk of heavy-resistance strength training (38 sessions). Maximal isometric muscle strength [maximal voluntary contraction (MVC)] increased from 291.1 ± 9.8 to 339.0 ± 10.2 N · m after training. Contractile RFD determined within time intervals of 30, 50, 100, and 200 ms relative to onset of contraction increased from 1,601 ± 117 to 2,020 ± 119 ( P < 0.05), 1,802 ± 121 to 2,201 ± 106 ( P < 0.01), 1,543 ± 83 to 1,806 ± 69 ( P < 0.01), and 1,141 ± 45 to 1,363 ± 44 N · m · s\u003Cjats:sup>−1\u003C\u002Fjats:sup>( P < 0.01), respectively. Corresponding increases were observed in contractile impulse ( P < 0.01–0.05). When normalized relative to MVC, contractile RFD increased 15% after training (at zero to one-sixth MVC; P < 0.05). Furthermore, muscle EMG increased ( P < 0.01–0.05) 22–143% (mean average voltage) and 41–106% (rate of EMG rise) in the early contraction phase (0–200 ms). In conclusion, increases in explosive muscle strength (contractile RFD and impulse) were observed after heavy-resistance strength training. These findings could be explained by an enhanced neural drive, as evidenced by marked increases in EMG signal amplitude and rate of EMG rise in the early phase of muscle contraction.\u003C\u002Fjats:p>",{"VI":1854,"EN":1855},"Tăng cường tỷ lệ phát triển lực và dẫn truyền thần kinh của cơ xương ở người sau khi tập luyện sức bền","Increased rate of force development and neural drive of human skeletal muscle following resistance training",{"VOID":1857},"12235031",{"VOID":1859},"10.1152\u002Fjapplphysiol.00283.2002","2025-01-06T16:46:30.837+00:00",[102],[101],"https:\u002F\u002Fwww.physiology.org\u002Fdoi\u002F10.1152\u002Fjapplphysiol.00283.2002",[1865,1886,1905,1926,1948],{"id":1866,"sortIndex":59,"researcher":26,"roles":1867,"affiliations":1868,"properties":1879},"7db1de46-4dc1-403a-8139-eca110c20139",[],[1869],{"id":1870,"sortIndex":36,"affiliation":1871,"properties":26},"1aa4ded7-bc47-4175-9489-f088c7564f31",{"id":1872,"createTime":1873,"updateTime":1873,"relativeEntities":1874,"slug":1875,"properties":1876,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"5e262277-cf57-4527-8b45-aeb9a1272416","2025-01-06T16:46:30.874+00:00",[],"Team-Danmark-Testcentre-Sports-Medicine-Research-Unit-Bispebjerg-Hospital-University-of-Copenhagen-DK-2200-Copenhagen-Denmark",{"title":1877},{"EN":1878},"Team Danmark Testcentre, Sports Medicine Research Unit, Bispebjerg Hospital, University of Copenhagen, DK-2200 Copenhagen, Denmark",{"openalex":1880,"orcid":1882,"title":1884},{"VOID":1881},"A5061040422",{"VOID":1883},"https:\u002F\u002Forcid.org\u002F0000-0001-9437-8749",{"EN":1885},"Peter Magnusson",{"id":1887,"sortIndex":111,"researcher":26,"roles":1888,"affiliations":1889,"properties":1900},"9132aa45-e049-4b23-bb28-0d1ca537e307",[],[1890],{"id":1891,"sortIndex":36,"affiliation":1892,"properties":26},"299103f1-325a-4379-92dd-7a275b9e22ee",{"id":1893,"createTime":1894,"updateTime":1894,"relativeEntities":1895,"slug":1896,"properties":1897,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"97bac82f-444e-40c0-bd4e-984e564425d4","2025-01-06T16:46:30.864+00:00",[],"Department-of-Neurophysiology-Institute-of-Medical-Physiology-",{"title":1898},{"EN":1899},"Department of Neurophysiology, Institute of Medical Physiology,",{"openalex":1901,"title":1903},{"VOID":1902},"A5063660505",{"EN":1904},"Poul Dyhre‐Poulsen",{"id":1906,"sortIndex":115,"researcher":26,"roles":1907,"affiliations":1908,"properties":1919},"9b59bdc1-0afe-4150-b8c7-f1be384128cc",[],[1909],{"id":1910,"sortIndex":36,"affiliation":1911,"properties":26},"e548ecbb-ce8f-43b5-8946-0f071c2f9f04",{"id":1912,"createTime":1913,"updateTime":1913,"relativeEntities":1914,"slug":1915,"properties":1916,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"64b01581-42d2-4634-be6c-f5bcaf1b3b0a","2025-01-06T16:46:30.906+00:00",[],"Anatomy-Department-C-Panum-Institute-",{"title":1917},{"EN":1918},"Anatomy Department C, Panum Institute,",{"openalex":1920,"orcid":1922,"title":1924},{"VOID":1921},"A5050130585",{"VOID":1923},"https:\u002F\u002Forcid.org\u002F0000-0002-6378-6595",{"EN":1925},"Erik B. 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resonance imaging (MRI) and computerized tomography (CT) are promising reference methods for quantifying whole body and regional skeletal muscle mass. Earlier MRI and CT validation studies used data-acquisition techniques and data-analysis procedures now outdated, evaluated anatomic rather than adipose tissue-free skeletal muscle (ATFSM), studied only the relatively large thigh, or found unduly large estimation errors. The aim of the present study was to compare arm and leg ATFSM cross-sectional area estimates (cm\u003Cjats:sup>2\u003C\u002Fjats:sup>) by using standard MRI and CT acquisition and image-analysis methods with corresponding cadaver estimates. A second objective was to validate MRI and CT measurements of adipose tissue embedded within muscle (interstitial adipose tissue) and surrounding muscle (subcutaneous adipose tissue). ATFSM area ( n = 119) by MRI [38.9 ± 22.3 (SD) cm\u003Cjats:sup>2\u003C\u002Fjats:sup>], CT (39.7 ± 22.8 cm\u003Cjats:sup>2\u003C\u002Fjats:sup>), and cadaver (39.5 ± 23.0 cm\u003Cjats:sup>2\u003C\u002Fjats:sup>) were not different ( P > 0.001), and both MRI and CT estimates of ATFSM were highly correlated with corresponding cadaver values [MRI: r = 0.99, SE of estimate (SEE) 3.9 cm\u003Cjats:sup>2\u003C\u002Fjats:sup>, P < 0.001; and CT: r = 0.99, SEE = 3.8 cm\u003Cjats:sup>2\u003C\u002Fjats:sup>, P < 0.001]. Similarly good results were observed between MRI- and CT-measured vs. cadaver-measured interstitial and subcutaneous adipose tissue. For MRI-ATFSM the intraobserver correlation for duplicate measurements in vivo was 0.99 [SEE = 8.7 cm\u003Cjats:sup>2\u003C\u002Fjats:sup>(2.9%), P < 0.001]. 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