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A simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants. Pediatrics. 1963;32:338–43.\nAmerican College of Medical Genetics and Genomics. Newborn screening ACT sheets and confirmatory algorithms. 2014. https:\u002F\u002Fwww.acmg.net\u002FACMG\u002FPublications\u002FACT_Sheets_and_Confirmatory_Algorithms\u002FNBS_ACT_Sheets_and_Algorithm_Table\u002FACMG\u002FPublications\u002FACT_Sheets_and_Confirmatory_Algorithms\u002FNBS_ACT_Sheets_and_Algorithms_Table.aspx?hkey=e2c16055-8cdc-4b22-a53b-b863622007c0. Accessed 15 Feb, 2015.\nAmerican College of Medical Genetics Newborn Screening Expert Group. Newborn screening: toward a uniform screening panel and system–executive summary. Pediatrics. 2006;117(5 Pt 2):S296–307.\nSocietà Italiana Studio Malattie Metaboliche Ereditarie and Società Italiana Screenings Neonatali. Guidelines for expanded neonatal screening and diagnostic confirmation 2008. http:\u002F\u002Fwww.simmesn.it\u002Fit\u002Fdocuments\u002Fglexpnbs2008.pdf. Accessed 12 Feb, 2015.\nScott CR, Elliott S, Buroker N, Thomas LI, Keutzer J, Glass M, et al. Identification of infants at risk for developing Fabry, Pompe, or mucopolysaccharidosis-I from newborn blood spots by tandem mass spectrometry. J Pediatr. 2013;163:498–503.\nChien YH, Lee NC, Chen CA, Tsai FJ, Tsai WH, Shieh JY, et al. Long-Term Prognosis of Patients with Infantile-Onset Pompe Disease Diagnosed by Newborn Screening and Treated since Birth. J Pediatr. 2014;(14):01035-X.\nPollitt RJ. International perspectives on newborn screening. J Inherit Metab Dis. 2006;29:390–6.\nLehotay DC, Hall P, Lepage J, Eichhorst JC, Etter ML, Greenberg CR. LC-MS\u002FMS progress in newborn screening. Clin Biochem. 2011;44:21–31.\nLoeber JG, Burgard P, Cornel MC, Rigter T, Weinreich SS, Rupp K, et al. Newborn screening programmes in Europe; arguments and efforts regarding harmonization. Part 1. From blood spot to screening result. J Inherit Metab Dis. 2012;35:603–11.\nBurgard P, Rupp K, Lindner M, Haege G, Rigter T, Weinreich SS, et al. Newborn screening programmes in Europe; arguments and efforts regarding harmonization. Part 2. From screening laboratory results to treatment, follow-up and quality assurance. J Inherit Metab Dis. 2012;35:613–25.\nWilson JMG, Jungner G. Principles and Practice of Screening for Disease. Geneva: WHO; 1968. http:\u002F\u002Fwww.who.int\u002Fbulletin\u002Fvolumes\u002F86\u002F4\u002F07-050112BP.pdf. Accessed 15 Feb, 2015.\nPetros M. Revisiting the Wilson-Jungner criteria: how can supplemental criteria guide public health in the era of genetic screening? Genet Med. 2012;14:129–34.",{"EN":122},"The goal of newborn screening is early identification of babies with a high risk for disorders that may not be clinically evident at birth, but have severe consequences if untreated. New insight into inherited diseases and the ability to test for numerous diseases using new technique such as tandem mass spectrometry have made it practical to greatly expand the number of conditions tested. The expanded neonatal screening is now available and relatively simple, but this represents only a part of the picture. Positive results require follow-up confirmation. Most disorders screened require confirmatory biochemical or genetic tests and specialist visits. An efficient system is needed for managing the care of affected newborns. Expanded newborn screening is not yet available in all Regions of Italy, but discussions aimed at organizing universal access are underway. If these are successful, the role of the pediatrician as the primary contact with the parents is expected to become even more important. We have conducted a survey of Italian pediatricians to assess their familiarity and opinions on newborn screening in general and on expanded newborn screening. All members of the Italian Association of Pediatricians (n = 9000) were invited to compile a 10-item questionnaire online. The response rate was 10 %, corresponding to 605 of 6000 active members. Respondents were from all Regions of Italy, with the highest number of responses coming from Lombardy (138, 22.8 %), Campania and Puglia (n = 61; 10.1 %). Interestingly, expanded neonatal screening was not available in any of these Regions at the time of the survey. Regarding their understanding of neonatal screening in general, most respondents (n = 552; 91.1 %) considered that they had at least a sufficient level of knowledge; however, only 59.6 % thought they had sufficient knowledge of expanded newborn screening. Successful implementation of a universal expanded NBS program will require efficient procedures for follow-up, diagnosis and treatment to prevent morbidity and mortality of infants and to reduce the period of uncertainty for unaffected families. Pediatricians may need additional training to allow them to fulfill their tasks of coordinating this process while keeping families informed and reassured.",{"EN":124},"Survey of Italian pediatricians’ perspectives and knowledge about neonatal screening",{"VOID":126},"10.1186\u002Fs13052-015-0147-1","PUBLICATION","VERIFIED","Auto Verify","https:\u002F\u002Fijponline.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs13052-015-0147-1",[132,148],{"id":133,"sortIndex":21,"researcher":20,"roles":134,"affiliations":136,"properties":145},"b9b8f334-185b-4da4-a6f0-5cfb0d3e2a88",[135],"AUTHOR",[137],{"id":20,"sortIndex":21,"affiliation":138,"properties":20},{"id":139,"createTime":140,"updateTime":140,"relativeEntities":141,"slug":20,"properties":142,"entityType":41,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"3732fabe-3a74-4758-a70c-7e69d59e659f","2023-12-22T03:44:13.978+00:00",[],{"title":143},{"VI":144},"Division of Inherited Metabolic Diseases, Reference Centre Expanded Newborn Screening Regione Veneto, Department of Pediatrics, University Hospital, Padova, Italy",{"title":146},{"VI":147},"Alberto B. 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Neonatology. 2014, 105 (3): 230-242. 10.1159\u002F000356704.\nLaptook A, Jackson GL: Cold stress and hypoglycemia in the late preterm (\"near-term\") infant: impact on nursery of admission. Semin Perinatol. 2006, 30 (1): 24-27. 10.1053\u002Fj.semperi.2006.01.014.\nKhashu M, Narayanan M, Bhargava S, Osiovich H: Perinatal outcomes associated with preterm birth at 33 to 36 weeks' gestation: a population-based cohort study. Pediatrics. 2009, 123 (1): 109-113. 10.1542\u002Fpeds.2007-3743.\nGuasch XD, Torrent FR, Martínez-Nadal S, Cerén CV, Saco MJ, Castellví PS: Late preterm infants: A population at underestimated risk. 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CL, Carroll MD, Flegal KM: High body mass index for age among US children and adolescents, 2003–2006. JAMA. 2008, 299: 2401-5. 10.1001\u002Fjama.299.20.2401.\nOlshansky SJ, Passaro DJ, Hershow RC, Layden J, Carnes BA, Brody J, Hayflick L, Butler RN, Allison DB, Ludwig DS: A potential decline in life expectancy in the United States in the 21st century. N Engl J Med. 2005, 352: 1138-1145. 10.1056\u002FNEJMsr043743.\nAlley DE, Chang VW: The changing relationship of obesity and disability, 1988–2004. JAMA. 2007, 298: 2020-7. 10.1001\u002Fjama.298.17.2020.\nSteinberger J, Daniels SR, Eckel RH, Hayman L, Lustig RH, McCrindle B, Mietus-Snyder ML, American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing and Council on Nutrition, Physical Activity, and Metabolism: Progress and challenges in metabolic syndrome in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2009, 119: 628-647. 10.1161\u002FCIRCULATIONAHA.108.191394.\nD’Adamo E, Santoro N, Caprio S: Metabolic syndrome in pediatrics: old concepts revised, new concepts discussed. Pediatr Clin N Am. 2011, 58: 1241-1255. 10.1016\u002Fj.pcl.2011.07.005.",{"EN":447},"Metabolic syndrome: new therapeutic approaches",{"VOID":449},"10.1186\u002F1824-7288-40-S1-A48","https:\u002F\u002Fijponline.biomedcentral.com\u002Farticles\u002F10.1186\u002F1824-7288-40-S1-A48",[452,467],{"id":453,"sortIndex":21,"researcher":20,"roles":454,"affiliations":455,"properties":464},"be3c6347-3c08-4084-9ef4-ac2e5e4eacbb",[135],[456],{"id":20,"sortIndex":21,"affiliation":457,"properties":20},{"id":458,"createTime":459,"updateTime":459,"relativeEntities":460,"slug":20,"properties":461,"entityType":41,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"4f938736-424e-47f6-914a-31ca9766fdef","2024-02-13T23:55:01.267+00:00",[],{"title":462},{"VI":463},"Hepatometabolic Department, “Bambino Gesù” Children’s Hospital, Rome, Italy",{"title":465},{"VI":466},"Claudia Della Corte",{"id":468,"sortIndex":98,"researcher":20,"roles":469,"affiliations":470,"properties":476},"f1510493-c08f-4b82-906c-dd3af8b9c099",[135],[471],{"id":20,"sortIndex":21,"affiliation":472,"properties":20},{"id":458,"createTime":459,"updateTime":459,"relativeEntities":473,"slug":20,"properties":474,"entityType":41,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":475},{"VI":463},{"title":477},{"VI":478},"Valerio Nobili",{"url":450,"publisher":480,"properties":508},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":481,"slug":10,"properties":482,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":486,"manageAffiliations":487,"indexDatabases":488,"url":20,"thumbnailPath":20,"statistic":503,"gsStatistic":20,"type":107,"analyzePriority":20},[],{"issn":483,"title":484,"url":485},{"VOID":13},{"EN":15},{"VOID":17},[],[],[489,496],{"id":56,"indexDatabase":490,"url":71,"indexYears":20,"academicFieldIds":495,"indexDatabaseRanking":20},{"id":58,"createTime":59,"updateTime":60,"relativeEntities":491,"label":492,"description":493,"key":67,"publicationTags":494,"standard":20},[],{"EN":63,"VI":63},{"VI":65,"EN":66},[69,70],[73],{"id":75,"indexDatabase":497,"url":88,"indexYears":89,"academicFieldIds":502,"indexDatabaseRanking":92},{"id":77,"createTime":78,"updateTime":79,"relativeEntities":498,"label":499,"description":500,"key":85,"publicationTags":501,"standard":20},[],{"EN":82,"VI":82},{"EN":82,"VI":84},[87],[91],{"impactFactor":21,"impactFactorByYear":504,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":95,"totalPublicationByYear":505,"totalCitation":21,"totalCitationByYear":506,"totalCitationPerPublication":21,"totalCitationPerPublicationByYear":507,"hindexLast5Year":21,"hindex":21},{},{"2009":97,"2010":98,"2014":99,"2017":97,"2018":100,"2019":101,"2020":102,"2021":103,"2022":99,"2023":98,"2024":104},{},{},{"volume":509,"pages":510},{"VOID":434},{"VOID":436},"2014-08-11",{"id":513,"createTime":514,"updateTime":515,"relativeEntities":516,"slug":517,"properties":518,"entityType":127,"verifyStatus":128,"verifyTime":527,"verifyNote":129,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":528,"fullTextUrl":20,"authors":529,"publicationType":163,"publisherRelationship":599,"citationCount":20,"citationInfo":20,"publishDate":632,"publishYear":438,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":20,"isForceReanalyzing":200},"4f610d6c-e65c-44f7-a47f-94f237ea8f71","2024-01-05T20:10:58.839+00:00","2025-01-29T23:54:22.179+00:00",[],"Prevalence-of-hypovitaminosis-D-and-predictors-of-vitamin-D-status-in-Italian-healthy-adolescents",{"references":519,"abstract":521,"title":523,"doi":525},{"VOID":520},"Ganji V, Zhang X, Tangpricha V: Serum 25-hydroxyvitamin D concentrations and prevalence estimates of hypovitaminosis D in the U.S. population based on assay-adjusted data. J Nutr. 2012, 142: 498-507. 10.3945\u002Fjn.111.151977.\nGonzález-Gross M, Valtueña J, Breidenassel C, Moreno LA, Ferrari M, Kersting M, De Henauw S, Gottrand F, Azzini E, Widhalm K, Kafatos A, Manios Y, Stehle P, HELENA Study Group: Vitamin D status among adolescents in Europe: the healthy lifestyle in Europe by nutrition in adolescence study. Br J Nutr. 2012, 107: 755-764. 10.1017\u002FS0007114511003527.\nAbsoud M, Cummins C, Lim MJ, Wassmer E, Shaw N: Prevalence and predictors of vitamin D insufficiency in children: a Great Britain population based study. PLoS One. 2011, 6: e22179-10.1371\u002Fjournal.pone.0022179.\nValtueña J, González-Gross M, Huybrechts I, Breidenassel C, Ferrari M, Mouratidou T, Gottrand F, Dallongeville J, Azzini E, Sioen I, Gómez-Martínez S, Cuenca-García M, Kersting M, Stehle P, Kafatos A, Manios Y, Widhalm K, Moreno LA: Factors associated with vitamin D deficiency in European adolescents: the HELENA study. J Nutr Sci Vitaminol (Tokyo). 2013, 59: 161-171. full_text.\nEarthman CP, Beckman LM, Masodkar K, Sibley SD: The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications. Int J Obes (Lond). 2012, 36: 387-396. 10.1038\u002Fijo.2011.119.\nGhergherechi R, Hazhir N, Tabrizi A: Comparison of vitamin D deficiency and secondary hyperparathyroidism in obese and non-obese children and adolescents. Pak J Biol Sci. 2012, 15: 147-151. 10.3923\u002Fpjbs.2012.147.151.\nMouratidou T, Vicente-Rodriguez G, Gracia-Marco L, Huybrechts I, Sioen I, Widhalm K, Valtueña J, González-Gross M, Moreno LA, HELENA Study Group: Associations of dietary calcium, vitamin D, milk intakes, and 25-hydroxyvitamin D with bone mass in Spanish adolescents: the HELENA study. J Clin Densitom. 2013, 16: 110-117. 10.1016\u002Fj.jocd.2012.07.008.\nSociety for Adolescent Health and Medicine: Recommended vitamin D intake and management of low vitamin D status in adolescents: a position statement of the society for adolescent health and medicine. J Adolesc Health. 2013, 52: 801-803.\nPekkinen M, Viljakainen H, Saarnio E, Lamberg-Allardt C, Mäkitie O: Vitamin D is a major determinant of bone mineral density at school age. PLoS One. 2012, 7: e40090-10.1371\u002Fjournal.pone.0040090.\nPitukcheewanont P, Austin J, Chen P, Punyasavatsut N: Bone health in children and adolescents: risk factors for low bone density. Pediatr Endocrinol Rev. 2013, 10: 318-335.\nCole TJ, Green PJ: Smoothing reference centile curves: the LMS method and penalized likelihood. Stat Med. 1992, 11: 1305-1319. 10.1002\u002Fsim.4780111005.\nCole TJ, Bellizzi MC, Flegal KM, Dietz WH: Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ. 2000, 320: 1240-1243. 10.1136\u002Fbmj.320.7244.1240.\nSaggese G, Baroncelli GI, Bertelloni S, Webb AR, Holick MF: Effetto delle stagioni sulla sintesi della vitamina D3 a 43° latitudine nord. Riv Ital Pediatr. 1992, 18: 30-36.\nHolick MF: Vitamin D deficiency. N Engl J Med. 2007, 357: 266-281. 10.1056\u002FNEJMra070553.\nBalk SJ, Council on Environmental Health, Section on Dermatology: Ultraviolet radiation: a hazard to children and adolescents. Pediatrics. 2011, 127: 588-597.\nHolick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM, Endocrine Society: Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011, 96: 1911-1930. 10.1210\u002Fjc.2011-0385.\nBraegger C, Campoy C, Colomb V, Decsi T, Domellof M, Fewtrell M, Hojsak I, Mihatsch W, Molgaard C, Shamir R, Turck D, van Goudoever J, ESPGHAN Committee on Nutrition: Vitamin D in the healthy European paediatric population. J Pediatr Gastroenterol Nutr. 2013, 56: 692-701. 10.1097\u002FMPG.0b013e31828f3c05.\nChinellato I, Piazza M, Sandri M, Peroni DG, Cardinale F, Piacentini GL, Boner AL: Serum vitamin D levels and exercise-induced bronchoconstriction in children with asthma. Eur Respir J. 2011, 37: 1366-1370. 10.1183\u002F09031936.00044710.\nLippi G, Montagnana M, Meschi T, Borghi L: Vitamin D concentration and deficiency across different ages and genders. Aging Clin Exp Res. 2012, 24: 548-551.\nDong Y, Pollock N, Stallmann-Jorgensen IS, Gutin B, Lan L, Chen TC, Keeton D, Petty K, Holick MF, Zhu H: Low 25-hydroxyvitamin D levels in adolescents: race, season, adiposity, physical activity, and fitness. Pediatrics. 2010, 125: 1104-1111. 10.1542\u002Fpeds.2009-2055.\nKim SH, Oh MK, Namgung R, Park MJ: Prevalence of 25-hydroxyvitamin D deficiency in Korean adolescents: association with age, season and parental vitamin D status. Public Health Nutr. 2014, 17: 122-130. 10.1017\u002FS1368980012004703.\nSantos BR, Mascarenhas LP, Satler F, Boguszewski MC, Spritzer PM: Vitamin D deficiency in girls from South Brazil: a cross-sectional study on prevalence and association with vitamin D receptor gene variants. BMC Pediatr. 2012, 12: 62-10.1186\u002F1471-2431-12-62.\nYu A, Kim J, Kwon O, Oh SY, Kim J, Yang YJ: The association between serum 25-hydroxyvitamin d concentration and consumption frequencies of vitamin d food sources in korean adolescents. Clin Nutr Res. 2013, 2: 107-114. 10.7762\u002Fcnr.2013.2.2.107.\nGordon CM, DePeter KC, Feldman HA, Grace E, Emans SJ: Prevalence of vitamin D deficiency among healthy adolescents. Arch Pediatr Adolesc Med. 2004, 158: 531-537. 10.1001\u002Farchpedi.158.6.531.\nSocietà Italiana di Pediatria: Abitudini e stili di vita degli adolescenti italiani. [http:\u002F\u002Fsip.it\u002Fwp-content\u002Fuploads\u002F2010\u002F05\u002FIndagine-Adolescenti-2011-2012.pdf]\nWagner CL, Greer FR: Prevention of rickets and vitamin D deficiency in infants, children and adolescents. Pediatrics. 2008, 122: 1142-1152. 10.1542\u002Fpeds.2008-1862.\nHolick MF: The D-lightful vitamin D for child health. J Parenter Enteral Nutr. 2012, 36 (Suppl 1): 9-19.\nHolick MF: Deficiency of sunlight and vitamin D. BMJ. 2008, 336: 1318-1319. 10.1136\u002Fbmj.39581.411424.80.\nSaintonge S, Bang H, Gerber LM: Implications of a new definition of vitamin D deficiency in a multiracial US adolescent population: The National Health and Nutrition Examination Survey III. Pediatrics. 2009, 123: 797-803. 10.1542\u002Fpeds.2008-1195.\nWalker GE, Ricotti R, Roccio M, Moia S, Bellone S, Prodam F, Bona G: Pediatric obesity and vitamin D deficiency: a proteomic approach identifies multimeric adiponectin as a key link between these conditions. PLoS One. 2014, 9: e83685-10.1371\u002Fjournal.pone.0083685.\nWortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF: Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000, 72: 690-693.\nAl-Musharaf S, Al-Othman A, Al-Daghri NM, Krishnaswamy S, Yusuf DS, Alkharfy KM, Al-Saleh Y, Al-Attas OS, Alokail MS, Moharram O, Yakout S, Sabico S, Chrousos GP: Vitamin D deficiency and calcium intake in reference to increased body mass index in children and adolescents. Eur J Pediatr. 2012, 171: 1081-1086. 10.1007\u002Fs00431-012-1686-8.\nAndıran N, Çelik N, Akça H, Doğan G: Vitamin D deficiency in children and adolescents. J Clin Res Pediatr Endocrinol. 2012, 4: 25-29. 10.4274\u002Fjcrpe.574.\nMarwaha RK, Tandon N, Reddy DR, Aggarwal R, Singh R, Sawhney RC, Saluja B, Ganie MA, Singh S: Vitamin D and bone mineral density status of healthy schoolchildren in northern India. Am J Clin Nutr. 2005, 82: 477-482.\nWeng FL, Shults J, Leonard MB, Stallings VA, Zemel BS: Risk factors for low serum 25-hydroxyvitamin D concentrations in otherwise healthy children and adolescents. Am J Clin Nutr. 2007, 86: 150-158.\nVan Horn LV, Bausermann R, Affenito S, Thompson D, Striegel-Moore R, Franko D, Albertson A: Ethnic differences in food sources of vitamin D in adolescent American girls: the National Heart, Lung, and Blood Institute Growth and Health Study. Nutr Res. 2011, 31: 579-585. 10.1016\u002Fj.nutres.2011.07.003.\nCranney A, Horsley T, O'Donnell S, Weiler H, Puil L, Ooi D, Atkinson S, Ward L, Moher D, Hanley D, Fang M, Yazdi F, Garritty C, Sampson M, Barrowman N, Tsertsvadze A, Mamaladze V: Effectiveness and safety of vitamin D in relation to bone health. Evid Rep Technol Assess (Full Rep). 2007, 158: 1-235.\nAtapattu N, Shaw N, Högler W: Relationship between serum 25-hydroxyvitamin D and parathyroid hormone in the search for a biochemical definition of vitamin D deficiency in children. Pediatr Res. 2013, 74: 552-556. 10.1038\u002Fpr.2013.139.\nSrivastava T, Garg U, Ruiz M, Dai H, Alon US: Serum 25(OH)-vitamin D level in children: is there a need to change the reference range based on 2011 Institute of Medicine Report?. Clin Pediatr (Phila). 2013, 52: 178-182. 10.1177\u002F0009922811425954.\nOutila TA, Kärkkäinen MU, Lamberg-Allardt CJ: Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density. Am J Clin Nutr. 2001, 74: 206-210.",{"EN":522},"Vitamin D plays an important role in health promotion during adolescence. Vitamin D deficiency and insufficiency are common in adolescents worldwide. Few data on vitamin D status and risk factors for hypovitaminosis D in Italian adolescents are currently available. 25-hydroxyvitamin D (25-OH-D) and parathyroid hormone (PTH) levels were evaluated in 427 Italian healthy adolescents (10.0-21.0 years). We used the following cut-off of 25-OH-D to define vitamin D status: deficiency \u003C 50 nmol\u002FL; insufficiency 50-75 nmol\u002FL; sufficiency ≥ 75 nmol\u002FL. Hypovitaminosis D was defined as 25-OH-D levels \u003C 75.0 nmol\u002FL and severe vitamin D deficiency as 25-OH-D levels \u003C 25.0 nmol\u002FL. We evaluated gender, residence, season of blood withdrawal, ethnicity, weight status, sun exposure, use of sunscreens, outdoor physical activity, and history of fractures as predictors of vitamin D status. Enrolled adolescents had a median serum 25-OH-D level of 50.0 nmol\u002FL, range 8.1-174.7, with 82.2% having hypovitaminosis D. Vitamin D deficiency and insufficiency were detected in 49.9% and 32.3% of adolescents, respectively. Among those with deficiency, 38 subjects were severely deficient (38\u002F427, 8.9% of the entire sample). Non-white adolescents had a higher prevalence of severe vitamin D deficiency than white subjects (6\u002F17-35.3% vs 32\u002F410-7.8% respectively, p = 0.002). Logistic regression showed increased risk of hypovitaminosis D as follows: blood withdrawal taken in winter-spring (Odds ratio (OR) 5.64) compared to summer-fall period; overweight-obese adolescents (OR 3.89) compared to subjects with normal body mass index (BMI); low sun exposure (OR 5.94) compared to moderate-good exposure and regular use of sunscreens (OR 5.89) compared to non regular use. Adolescents who performed \u003C 3 hours\u002Fweek of outdoor exercise had higher prevalence of hypovitaminosis D. Gender, residence, and history of fractures were not associated with vitamin D status. Serum 25-OH-D levels were inversely related to PTH (r = -0.387, p \u003C 0.0001) and BMI-SDS (r = -0.141, p = 0.007). 44\u002F427 (10.3%) adolescents showed secondary hyperparathyroidism. Italian adolescents have high prevalence of vitamin D deficiency and insufficiency. Pediatricians should tackle predictors of vitamin D status, favoring a healthier lifestyle and promoting supplementation in the groups at higher risk of hypovitaminosis D.",{"EN":524},"Prevalence of hypovitaminosis D and predictors of vitamin D status in Italian healthy 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Erba",{"id":546,"sortIndex":98,"researcher":20,"roles":547,"affiliations":548,"properties":557},"102fdd1f-301f-4295-be3e-cb56b87a148f",[135],[549],{"id":20,"sortIndex":21,"affiliation":550,"properties":20},{"id":551,"createTime":552,"updateTime":552,"relativeEntities":553,"slug":20,"properties":554,"entityType":41,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"2197ea3d-968a-44fa-9cee-23b9b6efa100","2024-01-05T20:10:58.858+00:00",[],{"title":555},{"VI":556},"Pediatric Clinic, University-Hospital Pisa, Pisa, Italy",{"title":558},{"VI":559},"Marta Del 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A, Pluta-Hadas K, Zurawski J, Janicka-Jedynska M, Kaczmarek E, Zachwieja J, et al. Electron-microscopic and immunohistochemical study in Henoch–Schoenlein nephritis. Ultrastruct Pathol. 2013;37:83–92.\nYamakawa T, Yamamoto I, Komatsuzaki Y, Niikura T, Okabayashi Y, Katsumata H, et al. Successful treatment of recurrent Henoch-Schönlein purpura nephritis in a renal allograft with allograft with tonsillectomy and steroid pulse therapy. Nephrology (Carlton). 2016;21:53–6.\nDavin JC, Ten Berge IJ, Weening JJ. What is the difference between IgA nephropathy and Henoch-Schönlein purpura nephritis? Kidney Int. 2001;59:823–34.\nKamitsuji H, Sakamoto S, Matsunaga T, Taira K, Kawahara S, Nakajima M. Intraglomerular deposition of fibrin\u002Ffibrinogen-related antigen in children with various renal diseases. Am J Pathol. 1988;133:61–72.\nShin JI, Park JM, Shin YH, Lee JS, Jeong HJ. Role of mesangial fibrinogen deposition in the pathogenesis of crescentic Henoch-Schonlein nephritis in children. J Clin Pathol. 2005;58:1147–51.\nShin JI, Park JM, Kim JH, Lee JS, Jeong HJ. Factors affecting histological regression of crescentic Henoch-Schönlein nephritis in children. Pediatr Nephrol. 2006;21:54–9.\nCounahan R, Winterborn MH, White RH, Heaton JM, Meadow SR, Bluett NH, et al. Prognosis of Henoch-Schönlein nephritis in children. Br Med J. 1977;2:11–4.\nSubspecialty Group of Nephrology; Society of Pediatrics; Chinese Medical Association. Evidence-based guidelines on diagnosis and treatment of childhood common renal diseases (II): evidence-based guideline on diagnosis and treatment of Henoch-Schonlein purpura nephritis. Zhonghua Er Ke Za Zhi. 2009;47:911–13.\nPan YX, Ye Q, Shao WX, Shang SQ, Mao JH, Zhang T, et al. Relationship between immune parameters and organ involvement in children with Henoch-Schonlein Purpura. PLoS One. 2014;9(12):e115261.\nBergón E, Granados R, Fernández-Segoviano P, Miravalles E, Bergón M. Classification of renal proteinuria: a simple algorithm. Clin Chem Lab Med. 2002;40:1143–50.\nOno T, Kanatsu K, Doi T, Sekita K, Onoe C, Nagai H, et al. Relationship of intraglomerular coagulation and platelet aggregation to glomerularsclerosis. Nephron. 1991;58:429–36.\nXu Q, Chen X, Fu B, Ye Y, Yu L, Wang J, et al. Integrin alphavbeta3-RGDS interaction mediates fibrin-induced morphological changes of glomerular endothelial cells. Kidney Int. 1999;56:1413–22.\nFlick MJ, LaJeunesse CM, Talmage KE, Witte DP, Palumbo JS, Pinkerton MD, et al. Fibrin (ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif. J Clin Invest. 2007;117:3224–35.\nPaul J, Strickland S, Melchor JP. Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. J Exp Med. 2007;204:1999–2008.\nMotojima M, Matsusaka T, Kon V, Ichikawa I. Fibrinogen that appears in Bowman's space of proteinuric kidneys in vivo activatespodocyte Toll-like receptors 2 and 4 in vitro. Nephron Exp Nephrol. 2010;114:e39–47.\nPatibandla PK, Tyagi N, Dean WL, Tyagi SC, Roberts AM, et al. Fibrinogen induces alterations of endothelial cell tight junction proteins. J Cell Physiol. 2009;221:195–203.\nSörensen I, Susnik N, Inhester T, Degen JL, Melk A, Haller H, Schmitt R. Fibrinogen, acting as a mitogen for tubulointerstitial fibroblasts, promotes renalfibrosis. Kidney Int. 2011;80:1035–44.\nCraciun FL, Ajay AK, Hoffmann D, Saikumar J, Fabian SL, Bijol V, et al. Pharmacological and genetic depletion of fibrinogen protects from kidney fibrosis. Am J Physiol Renal Physiol. 2014;307:F471–84.\nMao S, Xuan X, Sha Y, Zhao S, Zhu C, Zhang A, et al. Clinico-pathological association of Henoch-Schoenlein purpura nephritis and IgA nephropathy in children. Int J Clin Exp Pathol. 2015;8:2334–42.\nTrezzini C, Schüepp B, Maly FE, Jungi TW. Evidence that exposure to fibrinogen or to antibody directed against Mac-1 (CD11b\u002FCD18; CR3) modulates human monocyte effector functions. Br J Haematol. 1991;77:16–24.\nJensen T, Kierulf P, Sandset PM, Klingenberg O, Joø GB, Godal HC, et al. Fibrinogen and fibrin induce synthesis of proinflammatory cytokines from isolated peripheral blood mononuclear cells. Thromb Haemost. 2007;97:822–9.\nLi YY, Li CR, Wang GB, Yang J, Zu Y. Investigation of the change in CD4+ T cell subset in children with Henoch-Schonlein purpura. Rheumatol Int. 2012;32:3785–92.\nGuo M, Daines D, Tang J, Shen Q, Perrin RM, Takada Y, et al. Fibrinogen-gamma C-terminal fragments induce endothelial barrier dysfunction and microvascular leak via integrin-mediated and RhoA-dependent mechanism. Arterioscler Thromb Vasc Biol. 2009;29:394–400.\nPoterucha TJ, Wetter DA, Grande JP, Gibson LE, Camilleri MJ, Lohse CM. A retrospective comparison of skin and renal direct immunofluorescence findings in patients with glomerulonephritis in adult Henoch-Schönlein purpura. J Cutan Pathol. 2014;41:582–7.\nTanaka H, Onodera N, Waga S. Glomerulonephritis without IgA deposits in a case of Henoch-Schönlein purpura. Pediatr Nephrol. 1999;13:597–9.\nWest CD, McAdams AJ. Glomerulonephritis in Henoch-Schöenlein purpura without mesangial IgA deposition. Pediatr Nephrol. 1994;8:677–83.\nRonkainen J, Ala-Houhala M, Huttunen NP, Jahnukainen T, Koskimies O, Ormälä T, et al. Outcome of Henoch-Schoenlein nephritis with nephrotic-range proteinuria. Clin Nephrol. 2003;60:80–4.",{"EN":643},"Henoch-Schönlein purpura nephritis (HSPN) is the most common pediatric secondary glomerular disease. This study aimed to investigate the significance of glomerular fibrinogen (Fib) deposition in children with HSPN. Eighty-two patients with HSPN were enrolled retrospectively at the Children’s Hospital of Soochow University from January 2015 to March 2017. Patients were divided into groups according to the presence or absence and intensity of glomerular Fib deposits, and clinical and pathological features were compared among the groups. Glomerular Fib deposition was observed in 64 children (78.05%), including 1 Fib± case (1.22%), 23 Fib+ cases (28.05%), 37 Fib++ cases (45.12%), and 3 Fib+++ cases (3.66%). Significantly different levels of high-sensitivity C-reactive protein (hs-CRP), D-dimer (DD), proportions of CD19 + CD23+ cells and urine microalbumin:creatinine ratios (UMA\u002FCr) were noted among the different Fib deposition groups (no, mild and severe). Pairwise comparison in multiple groups revealed significantly increased hs-CRP, proportion of CD19 + CD23+ cells and UMA\u002FCr in the severe deposition group compared with the mild and no deposition groups, and remarkably increased DD levels were noted in the severe and mild deposition groups compared with the no deposition group. The degree of glomerular Fib deposition was positively correlated with the degree of glomerular IgA deposition, and the incidence of glomerular IgG deposition in the severe deposition group was increased compared with the no deposition group. HSPN children with glomerular Fib deposition, especially those with severe Fib deposition, exhibit more severely disordered immunologic function, inflammatory reactions and hypercoagulability; glomerular damage in these patients may also be more severe.",{"EN":645},"Significance of glomerular fibrinogen deposition in children with Henoch-Schönlein purpura nephritis",{"VOID":647},"10.1186\u002Fs13052-018-0538-1","https:\u002F\u002Fijponline.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs13052-018-0538-1",[650,667,682,701,713,730],{"id":651,"sortIndex":98,"researcher":20,"roles":652,"affiliations":653,"properties":664},"3b4a9130-bc6f-477f-8811-abf9af2b1e91",[135],[654],{"id":20,"sortIndex":21,"affiliation":655,"properties":20},{"id":656,"createTime":657,"updateTime":658,"relativeEntities":659,"slug":660,"properties":661,"entityType":41,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"027d3117-b761-4ee5-81c1-a4c95dea8017","2024-01-11T04:55:15.973+00:00","2025-06-11T15:53:39.555+00:00",[],"Department-of-Pediatrics-Taixing-Hospital-Affiliated-to-Yangzhou-University-Taixing-China",{"title":662},{"VI":663},"Department of Pediatrics, Taixing Hospital Affiliated to Yangzhou University, Taixing, China",{"title":665},{"VI":666},"Lusheng Huang",{"id":668,"sortIndex":97,"researcher":20,"roles":669,"affiliations":670,"properties":679},"e20c5c28-20b3-4829-9850-6fe99d7412fb",[135],[671],{"id":20,"sortIndex":21,"affiliation":672,"properties":20},{"id":673,"createTime":674,"updateTime":674,"relativeEntities":675,"slug":20,"properties":676,"entityType":41,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"8135daa1-6941-4eed-9446-b5395592f70c","2024-01-11T04:55:15.998+00:00",[],{"title":677},{"VI":678},"Department of Nephrology and Immunology, Soochow University Affiliated Children’s Hospital, Suzhou, China",{"title":680},{"VI":681},"Hangyun 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Li",{"id":714,"sortIndex":100,"researcher":20,"roles":715,"affiliations":716,"properties":727},"91799dbd-79d7-4ec0-b9ae-7e4120242792",[135],[717],{"id":20,"sortIndex":21,"affiliation":718,"properties":20},{"id":719,"createTime":720,"updateTime":721,"relativeEntities":722,"slug":723,"properties":724,"entityType":41,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"0a786e86-6706-4d62-8934-469c1e525bfb","2024-01-11T04:55:16.021+00:00","2025-06-11T23:22:42.790+00:00",[],"Department-of-Pathology-Soochow-University-Affiliated-Children-s-Hospital-Suzhou-China",{"title":725},{"VI":726},"Department of Pathology, Soochow University Affiliated Children’s Hospital, Suzhou, China",{"title":728},{"VI":729},"Xingdong 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JP, Gomes GC, Thofehrn MB. Health facility environment as humanization strategy care in the pediatric unit: systematic review. Rev Esc Enferm USP. 2014;48:530–9.\nGargantini G. Humanization in the management of hospitalized children and adolescents. Ital J Pediatr. 2014;40(Suppl 1):A31.\nPasche DF. National Humanization Policy as a bet for collective production of changes in management and care methods. Interface - Comunicação Saúde Educação. 2009;13(Suppl. 1):701–8.\nRede Humaniza SUS. http:\u002F\u002Fwww.redehumanizasus.net\u002F4-a-rede-humaniza-sus. Accessed 23 Aug 2017.\nNegri B. O processo de humanização dos serviços de saúde: a experiência do Programa Nacional de Humanização da Assistência Hospitalar. http:\u002F\u002Fwww.saude.sc.gov.br\u002FEventos\u002FHumaniza_SUS\u002FManual_%20Politica_Humanizacao.doc. Accessed 23 Aug 2017.\nMoreira MA, Lustosa AM, Dutra F, Barros Ede O, Batista JB, Duarte MC. Public humanization policies: integrative literature review. Cien Saude Colet. 2015;20:3231–42.\nNora CR, Junges JR. Humanization policy in primary health care: a systematic review. Rev Saude Publica. 2013;47:1186–200.\nMongiovi VG, dos AnjosRde C, Soares SB, Lago-Falcão TM. Conceptual reflections on health humanization: conception of nurses from intensive care units. Rev Bras Enferm. 2014;67:306–11.\nChernicharo Ide M, de Freitas FD, Ferreira MA. Humanization in nursing care: contribution to the discussion about the National Humanization Policy. Rev Bras Enferm. 2013;66:564–70.\nCorbani NM, Brêtas AC, Matheus MC. Humanization of nursing care: what is it? Rev Bras Enferm. 2009;62:349–54.\nGomes GC, Erdmann AL. The child care shared between the family and the nursing team in the hospital: a perspective for its humanization. Rev Gaucha Enferm. 2005;26:20–30.\nCasate JC, Corrêa AK. Humanization in health care: knowledge disseminated in Brazilian nursing literature. Rev Lat Am Enfermagem. 2005;13:105–11.\nSilva RCC, Oliveira ENB, Chagas MIO, Sousa, SMM, Rodrigues TB, Vasconcelos DP. Reading as a method of humanized care in the pediatric neurological clinic: a qualitative study. Online Brazilian Journal of Nursing, [S.l.], v. 9, n. 2, 2010. ISSN 1676–4285. http:\u002F\u002Fwww.objnursing.uff.br\u002Findex.php\u002Fnursing\u002Farticle\u002Fview\u002Fj.1676-4285.2010.3002. Accessed 23 Aug 2017.\nCeribelli C, Nascimento LC, Pacífico SM, de Lima RA. Reading mediation as a communication resource for hospitalized children: support for the humanization of nursing care. Rev Lat Am Enfermagem. 2009;17:81–7.\nJolley J, Shields L. The evolution of family-centered care. J Pediatr Nurs. 2009;24:164–70.\nCommittee on Hospital Care and Institute for Patient - and Family - Centered Care. Patient - and family - centered care and the pediatrician's role. Pediatrics. 2012;129:394–404.\nPettoello-Mantovani M, Campanozzi A, Maiuri L, Giardino I. Family-oriented and family-centered care in pediatrics. Ital J Pediatr. 2009;12; 35:12.\nAmerican Academy of Pediatrics, 2017. https:\u002F\u002Fwww.aap.org\u002Fen-us\u002Fabout-the-aap\u002Faap-press-room\u002FPages\u002FRedefining-Pediatric-Patient-and-Family-Centered-Care.aspx. Accessed 23 Aug 2017.\nKuo DZ, Houtrow AJ, Arango P, Kuhlthau KA, Simmons JM, Neff JM. Family-centered care: current applications and future directions in pediatric health care. Matern Child Health J. 2012;16:297–305.\nSisterhen LL, Blaszak RT, Woods MB, Smith CE. Defining family-centered rounds. Teach Learn Med. 2007;19:319–22.\nMittal VS, Sigrest T, Ottolini MC, Rauch D, Lin H, Kit B, et al. Family-centered rounds on pediatric wards: a PRIS network survey of US and Canadian hospitalists. Pediatrics. 2010;126:37–43.\nSandhu AK, Amin HJ, McLaughlin K, Lockyer J. Leading educationally effective family-centered bedside rounds. J Grad Med Educ. 2013;5:594–9.\nAragon SJ, McGuinn L, Bavin SA, Gesell S. Does pediatric patient-centeredness affect family trust? J Healthc Qual. 2010;32:23–31.\nRostami F, Hassan ST, Yaghmai F, Ismaeil SB, Suandi TB. Effects of family-centered care on the satisfaction of parents of children hospitalized in pediatric wards in a pediatric ward in Chaloos in 2012. Electron Phys. 2015;5:1078–84.\nAzuine RE, Singh GK, Ghandour RM, Kogan MD. Geographic, racial\u002Fethnic, and Sociodemographic disparities in parent-reported receipt of family-centered care among US children. Int J Family Med. 2015;2015:168521.\nToomey SL, Chien AT, Elliott MN, Ratner J, Schuster MA. Disparities in unmet need for care coordination: the national survey of children's health. Pediatrics. 2013;131:217–24.\nChild and Family-Centred Care. http:\u002F\u002Fwww.sickkids.ca\u002Fpatient-family-resources\u002Fchild-family-centred-care\u002Findex.html. Accessed 23 Aug 2017.\nSchor EL. American Academy of Pediatrics Task Force on the Family. Family Pediatrics: report of the Task force on the Family. Pediatrics. 2003;111(Suppl 2):1541–71.\nSouthall DP, Burr S. The child-friendly healthcare initiative (CFHI): healthcare provision in accordance with the UN convention on the rights of the child. Pediatrics. 2000;106:1054–64.\nClarke A. The child friendly health care initiative – an update: Andrew Clarke and sue Nicholson report on the continued need for universal standards for child health care and announce the launch of online resources to support implementation of child friendly standards. Paediatr Nurs. 2007;19:36–7.\nSumanović-Glamuzina D, Sesar I, Krišto B, Ostojić L. Child and family-centered care in the treatment of children - knowledge, attitudes, practice. Psychiatr Danub. 2013;25(Suppl 1):37–40.\nNicholson S, Clarke A. Child Friendly Healthcare – A manual for healthworkers. Sue Burr and David Southall Editors. Abridged by Alice and Oliver Ross. 2014. https:\u002F\u002Fwww.medbox.org\u002Fpaediatrics\u002Fchild-friendly-healthcare-a-manual-for-health-workers\u002Fpreview?q=. Accessed 23 Aug 2017.\nGuidelines of the Committee of Ministers of the Council of Europe on child-friendly health care. 2011. https:\u002F\u002Frm.coe.int\u002FCoERMPublicCommonSearchServices\u002FDisplayDCTMContent?documentId=090000168046ccef. Accessed 23 Aug 2017.\nBritish Association for Community Child Health. Introducing the “Family Friendly Framework”. A whole systems approach for the planning, delivery and improvement of services for children and families. 2014. http:\u002F\u002Fwww.bacch.org.uk\u002Fpolicy\u002FBACCH%20Family%20Friendly%20Framework%20final.pdf. Accessed 23 Aug 2017.\nKilkelly U, University College Cork, Ireland. Child-friendly health care: the views and experiences of children and young people in Council of Europe member States. MSN (2011) 1 E. COUNCIL OF EUROPE DOCUMENTS ON CHILD-FRIENDLY HEALTHCARE. Building a child-friendly Europe: turning a vision into reality. Conference on the Council of Europe Strategy for the Rights of the Child 2012-2015. 9th Council of Europe Conference of Health Ministers, Lisbon, 29-30 September 2011. http:\u002F\u002Fwww.coe.int\u002Ft\u002Fdg3\u002Fhealth\u002FChild_Friendly_Healthcare_Final_Report__English_version_.pdf. Accessed 23 Aug 2017.\nDamm L, Leiss U, Habeler U, Ehrich J. Improving care through better communication: understanding the benefits. J Pediatr. 2015;166:1098–9.\nEhrich J, Pettoello-Mantovani M, Lenton S, Damm L, Goldhagen J. Participation of children and young people in their health care: understanding the potential and limitations. J Pediatr. 2015;167:783–4.\nGerber-Grote A, Lenton S, Amelung V, Pettoello-Mantovani M, Ehrich JJ. Starting the debate on the role of health economics to support child friendly health Care in Europe. Pediatr. 2015;167:944–5. e2\nThink and Action Tank (TAT) on Children’s Right to Health. A rights- and equity-based platform and action cycle to advance child health and well-being. 2014. http:\u002F\u002Fmedia.wix.com\u002Fugd\u002F0f3826_ea06a3c2f71547dbb10168fc08d6ae24.pdf. Accessed 23 Aug 2017.\nThe CAHPS Program. Agency for Healthcare Research & Quality. 2016. https:\u002F\u002Fcahps.ahrq.gov\u002Fabout-cahps\u002Fcahps-program\u002Findex.html. Accessed 23 Aug 2017.\nCommunication Climate Assessment Toolkit. AHRQ Health Care Innovations Exchange. 2016. https:\u002F\u002Finnovations.ahrq.gov\u002Fqualitytools\u002Fcommunication-climate-assessment-toolkit. Accessed 23 Aug 2017.\nSimonelli F, Guerreiro AIF. The respect of children’s rights in hospital: an initiative of the International Network on Health Promoting Hospitals and Health Services. Final Report on the implementation process of the Self-evaluation Model and Tool on the respect of children’s rights in hospital. 2010. http:\u002F\u002Fwww.hphnet.org\u002Fimages\u002Fstories\u002FTask_Force_HPH-CA.Final_Report_SEMT1.pdf. Accessed 23 Aug 2017.\nGuerreiro AIF. Children’s rights in Hospital and Health Services: Manual and Tools for assessment and improvement. http:\u002F\u002Fwww.hphnet.org\u002Fimages\u002Fstories\u002FManual_on_Childrens_Rights_in_Hospital_and_Health_Services_March_2012.pdf. Accessed 23 Aug 2017.\nAgenas (2017). La valutazione della qualita' delle strutture ospedaliere secondo Ia prospettiva del cittadino - Agenas–Agenzia Nazionale per i servizi sanitari Regionali. http:\u002F\u002Fwww.agenas.it\u002Fempowerment\u002Fla-valutazione-della-qualita-delle-strutture-ospedaliere-secondo-ia-prospettiva-del-cittadino. Accessed 23 Aug 2017.\nBuffoli M, Bellini E, Bellagarda A, Di Noia M, Nickolova M, Capolongo S. Listening to people to cure people: the LpCp - tool, an instrument to evaluate hospital humanization. Ann Ig. 2014;26:447–55.\nTripodi M, Siano MA, De Anseris AGE, Mandato C, Quitadamo P, Guercio Nuzio S, et al. Evaluation of humanization of pediatric care degree in hospital: a pilot study. In: Abstract book of 72th Italian Society of Pediatrics National Conference. Florence, Italy; 2016. p. 46.\nAnalyse de l’activité hospitalière: E-SATIS. ATIH publication. 2017. http:\u002F\u002Fwww.atih.sante.fr\u002Fqualite-des-soins\u002Fe-satis. Accessed 23 Aug 2017.\nGallo KP, Hill LC, Hoagwood KE, Olin SC. A narrative synthesis of the components of and evidence for patient- and family-centered care. Clin Pediatr (Phila). 2016;55:333–46.\nOshimura JM, Downs SM, Saysana M. Family-centered rounding: can it impact the time of discharge and time of completion of studies at an academic children's hospital? HospPediatr. 2014l;4:228–32.\nRostami F, Hassan ST, Yaghmai F, Ismaeil SB, Suandi TB. Effects of family-centered care on the satisfaction of parents of children hospitalized in pediatric wards in a pediatric ward in Chaloos in 2012. Electron Physician. 2015;7:1078–84.\nMann KJ, Hoffman A, Miller D, Chadwick S, Bratcher D. The effect of a patient- and family-centered care curriculum on pediatrics residents' patient-centeredness. J Grad Med Educ. 2013;5:36–40.\nVajro P, Paolella G, Celentano E, et al. Characterization and burden of Campania children health migration across Italian regions during years 2006–2010: chance and\u002For necessity? Ital J Pediatr. 2012;38:58.\nFestini F, Siani P, Bisogni S, Marino Merlo A, Ciofi D. Rendiamo più accoglienti i nostri ospedali. Il risultato di una ricerca condotta dall'Associazione Culturale Pediatri e dalla Società Italiana di Scienze Infermieristiche Pediatriche. (A research ACP-SISIP: the humanization of our hospitals) QUADERNI ACP,2012; 19:195–8.\nInstitute for Patient-and family-centered care: about us. 2017. http:\u002F\u002Fwww.ipfcc.org\u002Fabout\u002Findex.html. Accessed 23 Aug 2017.",{"EN":788},"",{"EN":790},"The term “humanization” indicates the process by which people try to make something more human and civilized, more in line with what is believed to be the human nature. The humanization of care is an important and not yet a well-defined issue which includes a wide range of aspects related to the approach to the patient and care modalities. In pediatrics, the humanization concept is even vaguer due to the dual involvement of both the child and his\u002Fher family and by the existence of multiple proposed models. The present study aims to analyze the main existing humanization models regarding pediatric care, and the tools for assessing its grade. The main Humanization care programs have been elaborated and developed both in America (Brazil, USA) and Europe. The North American and European models specifically concern pediatric care, while the model developed in Brazil is part of a broader program aimed at all age groups. The first emphasis is on the importance of the family in child care, the second emphasis is on the child’s right to be a leader, to be heard and to be able to express its opinion on the program’s own care. Several tools have been created and used to evaluate humanization of care programs and related aspects. None, however, had been mutually compared. The major models of humanization care and the related assessment tools here reviewed highlight the urgent need for a more unifying approach, which may help in realizing health care programs closer to the young patient’s and his\u002Fher family needs.",{"EN":792},"Humanization of pediatric care in the world: focus and review of existing models and measurement 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T, Amino N, DeGroot LJ. Hashimoto’s Thyroiditis. In: De Groot LJ, Beck-Peccoz P, Chrousos G, Dungan K, Grossman A, Hershman JM, Koch C, McLachlan R, New M, Rebar R, Singer F, Vinik A, Weickert MO, editors. . South Dartmouth: MDText.com, Inc.; 2013. 2000-. 2013 Dec 20.\nWasniewska M, Vigone MC, Cappa M, Aversa T, Rubino M, De Luca F. Acute suppurative thyroiditis in childhood: relative frequency among thyroid inflammatory diseases. J Endocrinol Investig. 2007;30:346–7.\nKabelitz M, Liesenkötter KP, Stach B, Willgerodt H, Stäblein W, Singendonk W, et al. The prevalence of anti-thyroid peroxidase antibodies and autoimmune thyroiditis in children and adolescents in an iodine replete area. Eur J Endocrinol. 2003;148:301–7.\nWasniewska M, Corrias A, Salerno M, Mussa A, Capalbo D, Messina MF, et al. Thyroid function patterns at Hashimoto's thyroiditis presentation in childhood and adolescence are mainly conditioned by patients’ age. Horm Res Paediatr. 2012;78:232–6.\nDe Luca F, Santucci S, Corica D, Pitrolo E, Romeo M, Aversa T. Hashimoto’s thyroiditis in childhood: presentation modes and evolution over time. Ital J Pediatr. 2013;30:39–48.\nDe Luca F, Aversa T, Salzano G, Zirilli G, Sferlazzas C, Wasniewska M. Autoimmune thyroiditis. In: Bona G, De Luca F, Monzani A, editors. Thyroid diseases in childhood: Recent advances from basic science to clinical practice. Switzerland: Springer International publishing; 2015. p. 181–94.\nWasniewska M, Corrias A, Arrigo T, Lombardo F, Salerno M, Mussa A, et al. Frequency of Hashimoto’s thyroiditis antecedents in the history of children and adolescents with graves’ disease. Horm Res Paediatr. 2010;73:473–6.\nChampion B, Gopinath B, Ma G, El-Kaissi S, Wall JR. Conversion to Graves’ hyperthyroidism in a patient with hypothyroidism due to Hashimoto’s thyroiditis documented by real-time thyroid ultrasonography. Thyroid. 2008;18:1135–7.\nLudgate M, Emerson CH. Metamorphic thyroid autoimmunity. Thyroid. 2008;18:1035–7.\nTroisi A, Novati P, Sali L, Colzani M, Monti G, Cardillo C, et al. Graves’ thyrotoxicosis following Hashimoto’s thyroiditis. Res Rep Endocr Disord. 2013;3:13–5.\nZak T, Noczyńska A, Wasikowa R, Zaleska-Dorobisz U, Golenko A. Chronic autoimmune thyroid disease in children and adolescents in the years 1999-2004 in lower Silesia, Poland. Hormones (Athens). 2005;4:45–8.\nSvensson J, Ericsson UB, Nilsson P, Olsson C, Jonsson B, Lindberg B, et al. Levothyroxine treatment reduces thyroid size in children and adolescents with chronic autoimmune thyroiditis. J Clin Endocrinol Metab. 2006;91:1729–34.\nDemirbilek H, Kandemir N, Gonc EN, Ozon A, Alikasifoglu A. Assessment of thyroid function during the long course of Hashimoto's thyroiditis in children and adolescents. Clin Endocrinol. 2009;71:451–4.\nGopalakrishnan S, Chugh PK, Chhillar M, Ambardar VK, Sahoo M, Sankar R. Goitrous autoimmune thyroiditis in a pediatric population: a longitudinal study. Pediatrics. 2008;122:e670–4.\nde Vries L, Bulvik S, Phillip M. Chronic autoimmune thyroiditis in children and adolescents: at presentation and during long-term follow-up. Arch Dis Child. 2009;94:33–7.\nÖzen S, Berk Ö, Şimşek DG, Darcan S. Clinical course of Hashimoto's thyroiditis and effects of levothyroxine therapy on the clinical course of the disease in children and adolescents. J Clin Res Pediatr Endocrinol. 2011;3:192–7.\nSkarpa V, Kousta E, Tertipi A, Anyfandakis K, Vakaki M, Dolianiti M, et al. Epidemiological characteristics of children with autoimmune thyroid disease. Hormones (Athens). 2011;10:207–4.\nRadetti G, Gottardi E, Bona G, Corrias A, Salardi S, Loche S, et al. The natural history of euthyroid Hashimoto’s thyroiditis in children. J Pediatr. 2006;149:827–32.\nRadetti G, Maselli M, Buzi F, Corrias A, Mussa A, Cambiaso P, et al. The natural history of the normal\u002Fmild elevated TSH serum levels in children and adolescents with Hashimoto's thyroiditis and isolated hyperthyrotropinaemia: a 3-year follow-up. Clin Endocrinol. 2012;76:394–8.\nAversa T, Corrias A, Salerno M, Tessaris D, Di Mase R, Valenzise M, et al. Five-year prospective evaluation of thyroid function test evolution in children with Hashimoto's Thyroiditis presenting with either Euthyroidism or subclinical hypothyroidism. Thyroid. 2016;26:1450–6.\nVanderpump MP, Tunbridge WM. Epidemiology and prevention of clinical and subclinical hypothyroidism. Thyroid. 2002;12:839–47.\nDe Luca F, Corrias A, Salerno M, Wasniewska M, Gastaldi R, Cassio A, et al. Peculiarities of graves’ disease in children and adolescents with Down’s syndrome. Eur J Endocrinol. 2010;162:591–5.\nAversa T, Lombardo F, Corrias A, Salerno M, De Luca F, Wasniewska M. 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J Clin Res Pediatr Endocrinol. 2011;3:18–21.",{"EN":1040},"Aim of this commentary is to summarize the salient literature views on the relationships between presentation and evolution patterns of thyroid function in children with Hashimoto’s thyroiditis (HT). According to the most recent reports, children with HT and subclinical hypothyroidism (SH) are more prone to the risk of developing severe thyroid dysfunctions over time, if compared to those presenting with euthyroidism. In contrast, children presenting with HT and either overt or subclinical hyperthyroidism are incline to exhibit a definitive resolution of the hyperthyroid phase within some months, although there is a wide variability between the different individuals. The natural history of frank hypothyroidism in the children with HT has never been investigated so far, since in these cases an immediate onset of replacement treatment is mandatory. 1) a deterioration of thyroid status over time may be observed especially in the children presenting with SH, but also in those presenting with euthyroidism; 2) a definitive resolution of the hyperthyroid phase is generally observed in those presenting with either overt or subclinical hyperthyroidism.",{"EN":1042},"Thyroid function test evolution in children with Hashimoto’s thyroiditis is closely conditioned by the biochemical picture at 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Am J Hum Genet. 2000;67(Suppl A):1635.\nValstar MJ, Ruijter GJ, van Diggelen OP, Poorthuis BJ, Wijburg FA. Sanfilippo syndrome: a mini-review. J Inherit Metab Dis 2008;31:240–252.\nWeber B, van de Kamp JJ, Kleijer WJ, Guo XH, Blanch L, van Diggelen OP, et al. Identification of 16 sulfamidase gene mutations including the common R74C in patients with mucopolysaccharidosis type IIIA (Sanfilippo a). J Inherit Metab Dis. 1998;21:416–22.\nBunge S, Ince H, Steglich C, Kleijer WJ, Beck M, Zaremba J, et al. Identification of 16 sulfamidase gene mutations including the common R74C in patients with mucopolysaccharidosis type IIIA (Sanfilippo a). hum. Mutat. 1997;10:479–85.\nDi Natale P, Balzano N, Esposito S, Villani GR. Identification of molecular defects in Italian Sanfilippo a patients including 13 novel mutations. Hum Mutat 1998;11:313–320.\nWeber B, Blanch L, Clements PR, Scott HS, Hopwood JJ. Cloning and expression of the gene involved in Sanfilippo B syndrome (mucopolysaccharidosis III B). Hum Mol Genet. 1996;5:771–7.\nZhao HG, Li HH, Bach G, Schmidtchen A, Neufeld EF. The molecular basis of Sanfilippo syndrome type B. Proc Natl Acad Sci U S A. 1996;93:6101–5.\nYogalingam G, Hopwood JJ. Molecular genetics of mucopolysaccharidosis type IIIA and IIIB: diagnostic, clinical, and biological implications. Hum Mutat. 2001;18:264–81.\nFeldhammer M, Durand S, Mrazova L, Boucher RM, Laframboise R, Steinfeld R, et al. Sanfilippo syndrome type C: mutation spectrum in the heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase (HGSNAT) gene. Hum Mutat. 2009;30:918–25.\nBerger-Plantinga EG, Vanneste JA, Groener JE, van Schooneveld MJ. Adult-onset dementia and retinitis pigmentosa due to mucopolysaccharidosis III-C in two sisters. J Neurol 2004; 251:479–481.\nRuijter GJ, Valstar MJ, van de Kamp JM, van der Helm RM, Durand S, van Diggelen OP, et al. Clinical and genetic spectrum of Sanfilippo type C (MPS IIIC) disease in the Netherlands. Mol Genet Metab. 2008;93:104–11.\nRobertson DA, Callen DF, Baker EG, Morris CP, Hopwood JJ. Chromosomal localization of the gene for human glucosamine-6-sulphatase to 12q14. Hum Genet. 1988;79:175–8.\nMok A, Cao H, Hegele RA. Genomic basis of mucopolysaccharidosis type IIID (MIM 252940) revealed by sequencing of GNS encoding N-acetylglucosamine-6-sulfatase. Genomics. 2003;81:1–5.\nHarmatz P, Mengel KE, Giugliani R, Valayannopoulos V, Lin SP, Parini R, et al. The Morquio a clinical assessment program: baseline results illustrating progressive, multisystemic clinical impairments in Morquio a subjects. Mol Genet Metab. 2013;109:54–61.\nNakashima Y, Tomatsu S, Hori T, Fukuda S, Sukegawa K, Kondo N, et al. Mucopolysaccharidosis IV a: molecular cloning of the human N acetylgalactosamine-6-sulfatase gene (GALNS) and analysis of the 5′ flanking region. Genomics. 1994;20:99–104.\nTomatsu S, Fukuda S, Masue M, Sukegawa K, Fukao T, Yamagishi A, et al. Morquio disease: isolation, characterization and expression of full-length cDNA for human N-acetylgalactosamine-6-sulfate sulfatase. Biochem Biophys Res Commun. 1991;181:677–83.\nPshezhetsky AV, Ashmarina M. Lysosomal multienzyme complex: biochemistry, genetics, and molecular pathophysiology. Prog Nucleic Acid Res Mol Biol. 2001;69:81–114.\nWood TC, Harvey K, Beck M, Burin MG, Chien YH, Church HJ, et al. Diagnosing mucopolysaccharidosis IVA. J Inherit Metab Dis. 2013;36:293–307.\nTomatsu S, Fukuda S, Cooper A Wraith JE, Rezvi GM, Yamagishi A, et al. Mucopolysaccharidosis IVA: identification of a common missense mutation I113F in the N-acetylgalactosamine-6-sulfate sulfatase gene. Am J Hum Genet. 1995;57:556–63.\nYamada N, Fukuda S, Tomatsu S, Muller V, Hopwood JJ, Nelson J, et al. Molecular heterogeneity in mucopolysaccharidosis IVA in Australia and Northern Ireland: nine novel mutations including T312S, a common allele that confers a mild phenotype. Hum Mutat. 1998;11:202–8.\nCatarzi S, Giunti L, Papadia F, Gabrielli O, Guerrini R, Donati MA, et al. Morquio a syndrome due to maternal uniparental isodisomy of the telomeric end of chromosome 16. Mol Genet Metab. 2012;105:438–42.\nMorrone A, Tylee KL, Al-Sayed M, Brusius-Facchin AC, Caciotti A, Church HJ, et al, Molecular testing of 163 patients with Morquio A (mucopolysaccharidosis IVA) identifies 39 novel GALNS mutations. Mol Genet Metab 2014;112:160–170; erratum in: Mol Genet Metab. 2014;113:237.\nCaciotti A, Tonin R, Rigoldi M, Ferri L, Catarzi S, Cavicchi C, et al. Optimizing the molecular diagnosis of GALNS: novel methods to define and characterize Morquio-a syndrome-associated mutations. Hum Mutat. 2015;36:357–68.\nMorreau H, Galjart NJ, Gillemans N, Willemsen R, van der Horst GTJ, d’Azzo A. Alternative splicing of β-galactosidase mRNA generates the classic lysosomal enzyme and a β-galactosidase-related protein. J Biol Chem 1989;264:29655–29663.\nHinek A. Biological roles of the non-integrin elastin\u002Flaminin receptor. Biol Chem. 1996;377:471–80.\nPrivitera S, Prody CA, Callhan JW, Hinek A. The 67kDa enzymatically inactive alternatively spliced variant of β-galactosidase is identical to the elastin\u002Flaminin-binding protein. J Biol Chem. 1998;273:6319–26.\nOshima A, Yoshida K, Shimmoto M, Fukuhara Y, Sakuraba H, Suzuki Y. Human beta-galactosidase gene mutations in Morquio B disease. Am J Hum Genet. 1991;49:1091–3.\nSuzuki Y, Oshima A. Namba E. β-Galactosidase deficiency (β-galactosidosis) GM1 gangliosidosis and Morquio B disease. In: Scriver CR, Beaudet AL, Sly WS, Valle D, editors. The metabolic and molecular bases of inherited disease. New York: McGraw-Hill; 2001. p. 3775–809.\nPaschke E, Milos I, Kreimer-Erlacher H, Hoefler G, Beck M, Hoeltzenbein M, et al. Mutation analyses in 17 patients with deficiency in acid beta-galactosidase: three novel point mutations and high correlation of mutation W273L with Morquio disease type B. Hum Genet. 2001;109:159–66.\nSantamaria R, Chabás A, Coll MJ, Miranda CS, Vilageliu L, Grinberg D. Twenty-one novel mutations in the GLB1 gene identified in a large group of GM1 gangliosidosis and Morquio B patients: possible common origin for the prevalent p.R59H mutation among gypsies. Hum Mutat. 2006;27:1060.\nCaciotti A, Garman SC, Rivera-Colón Y, Procopio E, Catarzi S, Ferri L, et al. GM1 gangliosidosis and Morquio B disease: an update on genetic alterations and clinical findings. Biochim Biophys Acta. 2011;1812:782–90.\nSantamaria R, Blanco M, Chabás A, Grinberg D, Vilageliu L. Identification of 14 novel GLB1 mutations, including five deletions, in 19 patients with GM1 gangliosidosis from South America. Clin Genet. 2007;71:273–9.\nMoore T, Bernstein JA, Casson-Parkin S, Cowan TM. β-Galactosidosis in patient with intermediate GM1 and MBD phenotype. JIMD Rep. 2013;7:77–9.\nGort L, Santamaria R, Grinberg D, Vilageliu L, Chabás A. Identification of a novel pseudodeficiency allele in the GLB1 gene in a carrier of GM1 gangliosidosis. Clin Genet. 2007;72:109–11.\nModaressi S, Rupp K, von Figura K, Peters C. Structure of the human arylsulfatase B gene. Biol Chem Hoppe Seyler 1993;374:327–335.\nSandberg S, Deanching M, Hoganson G, Wenger D, Whiley C. Pseudo-deficiency allele of the N-acetylgalactosamine-4-sulfatase gene identified in a family with Maroteaux-Lamy syndrome (mucopolysaccharidosis type VI). Mol Genet Metab. 2008;93:S14–46.\nZanetti A, Ferraresi E, Picci L, Filocamo M, Parini R, Rosano C, et al. Segregation analysis in a family at risk for the Maroteaux-Lamy syndrome conclusively revelas c.1151G>a (p.S384N) as to be a polymorphism. Eur J Hum Genet. 2009;17(9):1160–4.\nKarageorgos L, Brooks DA, Pollard A, Melville EL, Hein LK, Clements PR, et al. Mutational analysis of 105 mucopolysaccharidosis type VI patients. Hum Mutat. 2007;28:897–903.\nMiller RD, Hoffmann JW, Powell PP, Kyle JW, Shipley JM, Bachinsky DR, Sly WS. Cloning and characterization of the human beta-glucuronidase gene. Genomics. 1990;7:280–3.\nVervoort R, Islam MR, Sly W, Chaba A, Wevers R, de Jong J, et al. A pseudodeficiency allele (D152N) of the human beta-glucuronidase gene. Am J Hum Genet. 1995;57:798–804.\nFrost GI, Heng HH, Scherer SW, Mohapatra G, Stern R. The hyaluronidase gene HYAL1 maps to chromosome 3p21.2-p21.3 in human and 9F1-F2 in mouse, a conserved candidate tumor suppressor locus. Genomics. 1998;48:63–70.\nTriggs-Raine F, Salo TJ, Zhang H, Wicklow BA, Natowicz MR. Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX. Proc Natl Acad Sci U S A. 1999;96:6296–300.\nImundo L, Leduc CA, Guha S, Brown M, Perino G, Gushulak L, et al. A complete deficiency of Hyaluronoglucosaminidase 1 (HYAL1) presenting as familial juvenile idiopathic arthritis. J Inherit Metab Dis. 2001;34:1013–22.",{"EN":1191},"Mucopolysaccharidoses (MPS) are rare inherited disorders caused by a deficit of the lysosomal hydrolases involved in the degradation of mucopolysaccharides, also known as glycosaminoglycans (GAGs). They are all monogenic defects, transmitted in an autosomal recessive way, except for MPS type II which is X-linked. The enzymatic deficit causes a pathologic accumulation of undegraded or partially degraded substrates inside lysosomes as well as in the extracellular compartment. MPS generally present with recognizable signs and symptoms to raise a clinical suspicion. However, although they have individual peculiarities, often signs and symptoms may overlap between different MPS types. Therefore, a deeper evaluation of specific disease biomarkers becomes necessary to reach an appropriate diagnosis. This paper stresses the central role of the laboratory in completing and confirming the clinical suspicion of MPS according to a standardized procedure: first, a biochemical evaluation of the patient samples, including qualitative\u002Fquantitative urinary GAG analysis and a determination of enzyme activities, and then the molecular diagnosis. We also encourage a constant and close communication between clinicians and laboratory personnel to address a correct and early MPS diagnosis.",{"EN":1193},"Biochemical and molecular analysis in mucopolysaccharidoses: what a paediatrician must know",{"VOID":1195},"10.1186\u002Fs13052-018-0553-2","https:\u002F\u002Fijponline.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs13052-018-0553-2",[1198,1213,1238,1253],{"id":1199,"sortIndex":21,"researcher":20,"roles":1200,"affiliations":1201,"properties":1210},"448d904f-cbda-422a-9f3c-f8b21889fef3",[135],[1202],{"id":20,"sortIndex":21,"affiliation":1203,"properties":20},{"id":1204,"createTime":1205,"updateTime":1205,"relativeEntities":1206,"slug":20,"properties":1207,"entityType":41,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"2690db73-9e7c-453f-8ad0-c81f0699f0ae","2023-12-31T09:28:17.889+00:00",[],{"title":1208},{"VI":1209},"Laboratorio di Genetica Molecolare e Biobanche, Istituto G. Gaslini, Genova, Italy",{"title":1211},{"VI":1212},"Mirella Filocamo",{"id":1214,"sortIndex":99,"researcher":20,"roles":1215,"affiliations":1216,"properties":1235},"64f9bdda-cfc8-4798-9b0b-c3cbeb4788a1",[135],[1217,1227],{"id":1218,"sortIndex":98,"affiliation":1219,"properties":1226},"c9e94a5d-346f-4f4f-9066-3ce6086af282",{"id":1220,"createTime":1221,"updateTime":1221,"relativeEntities":1222,"slug":20,"properties":1223,"entityType":41,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"53988317-91e4-4237-a8fd-de79a7deb681","2023-12-19T16:43:22.894+00:00",[],{"title":1224},{"VI":1225},"Department of NEUROFARBA, University of Florence, Florence, Italy",{},{"id":20,"sortIndex":21,"affiliation":1228,"properties":20},{"id":1229,"createTime":1230,"updateTime":1230,"relativeEntities":1231,"slug":20,"properties":1232,"entityType":41,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"dc4c34de-21e3-4e78-917f-b45bb78fdb77","2023-12-31T09:28:17.930+00:00",[],{"title":1233},{"VI":1234},"Neuroscience Department, Molecular and Cell Biology Laboratory of Neurometabolic Diseases, Meyer Children’s Hospital, University of Florence, Florence, Italy",{"title":1236},{"VI":1237},"Amelia Morrone",{"id":1239,"sortIndex":98,"researcher":20,"roles":1240,"affiliations":1241,"properties":1250},"99276dcb-d8c0-4357-b931-89b8bfe420df",[135],[1242],{"id":20,"sortIndex":21,"affiliation":1243,"properties":20},{"id":1244,"createTime":1245,"updateTime":1245,"relativeEntities":1246,"slug":20,"properties":1247,"entityType":41,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"d2597a7b-38bc-4107-960a-c6d061f1292f","2023-12-31T09:28:17.906+00:00",[],{"title":1248},{"VI":1249},"Laboratory of Diagnosis and Therapy of Lysosomal Disorders, Department of Women’s and Children’s Health, University of Padova, Padova, Italy",{"title":1251},{"VI":1252},"Rosella Tomanin",{"id":1254,"sortIndex":97,"researcher":20,"roles":1255,"affiliations":1256,"properties":1267},"bf0daa74-322a-4c7e-8dab-70059ad348d5",[135],[1257],{"id":20,"sortIndex":21,"affiliation":1258,"properties":20},{"id":1259,"createTime":1260,"updateTime":1261,"relativeEntities":1262,"slug":1263,"properties":1264,"entityType":41,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"b31a0837-68f0-4f9f-ae25-1464fdc0573b","2023-12-11T13:02:51.406+00:00","2024-11-28T21:56:49.351+00:00",[],"School-of-Medicine-and-Surgery-University-of-Milano-Bicocca-Monza-Italy",{"title":1265},{"VI":1266},"School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy",{"title":1268},{"VI":1269},"Francesca Bertola",{"url":1196,"publisher":1271,"properties":1299},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1272,"slug":10,"properties":1273,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1277,"manageAffiliations":1278,"indexDatabases":1279,"url":20,"thumbnailPath":20,"statistic":1294,"gsStatistic":20,"type":107,"analyzePriority":20},[],{"issn":1274,"title":1275,"url":1276},{"VOID":13},{"EN":15},{"VOID":17},[],[],[1280,1287],{"id":56,"indexDatabase":1281,"url":71,"indexYears":20,"academicFieldIds":1286,"indexDatabaseRanking":20},{"id":58,"createTime":59,"updateTime":60,"relativeEntities":1282,"label":1283,"description":1284,"key":67,"publicationTags":1285,"standard":20},[],{"EN":63,"VI":63},{"VI":65,"EN":66},[69,70],[73],{"id":75,"indexDatabase":1288,"url":88,"indexYears":89,"academicFieldIds":1293,"indexDatabaseRanking":92},{"id":77,"createTime":78,"updateTime":79,"relativeEntities":1289,"label":1290,"description":1291,"key":85,"publicationTags":1292,"standard":20},[],{"EN":82,"VI":82},{"EN":82,"VI":84},[87],[91],{"impactFactor":21,"impactFactorByYear":1295,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":95,"totalPublicationByYear":1296,"totalCitation":21,"totalCitationByYear":1297,"totalCitationPerPublication":21,"totalCitationPerPublicationByYear":1298,"hindexLast5Year":21,"hindex":21},{},{"2009":97,"2010":98,"2014":99,"2017":97,"2018":100,"2019":101,"2020":102,"2021":103,"2022":99,"2023":98,"2024":104},{},{},{"volume":1300,"pages":1301},{"VOID":773},{"VOID":1302},"35-45","2018-11-16",{"id":1305,"createTime":1306,"updateTime":1306,"relativeEntities":1307,"slug":20,"properties":1308,"entityType":127,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":1315,"fullTextUrl":20,"authors":1316,"publicationType":163,"publisherRelationship":1395,"citationCount":20,"citationInfo":20,"publishDate":1427,"publishYear":199,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":20,"isForceReanalyzing":200},"938757da-8366-4d3b-ba8b-66f854eb5236","2023-12-10T23:51:45.457+00:00",[],{"references":1309,"title":1311,"doi":1313},{"VOID":1310},"Siegrist C-A: Neonatal and early life vaccinology. Vaccine. 2011, 19 (25-26): 3331-3346.\nCrawford NW, Bines JE: Optimizing immunization in pediatric special risk groups. Expert Rev Vaccines. 2011, 10 (2): 175-186. 10.1586\u002Ferv.10.157.\nCommitee On Infectious Diseases: Recommended childhood and adolescent immunization schedules--United States, 2012. Pediatrics. 2012, 129 (2): 385-386.\nSaari TN: American Academy of Pediatrics Committee on Infectious Diseases. Immunization of preterm and low birth weight infants. American Academy of Pediatrics Committee on Infectious Diseases. Pediatrics. 2003, 112 (1 Pt 1): 193-198.\nCzajka H, Lauterbach R, et al: Vaccination of preterm infants by polyvalent vaccines: immunogenicity and safety- review of literature. Dev Period Med. 2014, 18 (3): 360-366.\nD'Angio: Active immunization of premature and low birth-weight infants: a review of immunogenicity, efficacy, and tolerability. Paediatr Drugs. 2007, 9 (1): 17-32. 10.2165\u002F00148581-200709010-00003.\nEsposito S, Fumagalli M, et al: Immunogenicity, safety and tolerability of vaccination in premature infants. Expert Rev Vaccines. 2012, 11 (10): 1199-1209. 10.1586\u002Ferv.12.93.\nTozzi A, Piga S, et al: Timeliness of routine immunization in a population-based Italian cohort of very preterm infants: Results of the ACTION follow-up project. Vaccine. 2014, 32 (7): 793-799. 10.1016\u002Fj.vaccine.2013.12.044.",{"EN":1312},"Issues of vaccination in premature infants: an overview",{"VOID":1314},"10.1186\u002F1824-7288-41-S1-A20","https:\u002F\u002Fijponline.biomedcentral.com\u002Farticles\u002F10.1186\u002F1824-7288-41-S1-A20",[1317,1332,1344,1359,1371,1383],{"id":1318,"sortIndex":98,"researcher":20,"roles":1319,"affiliations":1320,"properties":1329},"93876116-0f2c-4525-b9bc-3bf5d6ab369a",[135],[1321],{"id":20,"sortIndex":21,"affiliation":1322,"properties":20},{"id":1323,"createTime":1324,"updateTime":1324,"relativeEntities":1325,"slug":20,"properties":1326,"entityType":41,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"b892669f-c51e-40ed-a9f4-9fd25ef39fe7","2023-12-10T23:51:45.501+00:00",[],{"title":1327},{"VI":1328},"SC Neonatologia e TINO, Ospedale Sant'Anna, AOU Città della Salute e della Scienza, Torino, Italy",{"title":1330},{"VI":1331},"Roberta Calzedda",{"id":1333,"sortIndex":100,"researcher":20,"roles":1334,"affiliations":1335,"properties":1341},"78e6a41b-28f6-4dd8-b0c5-f1ddc05f45ba",[135],[1336],{"id":20,"sortIndex":21,"affiliation":1337,"properties":20},{"id":1323,"createTime":1324,"updateTime":1324,"relativeEntities":1338,"slug":20,"properties":1339,"entityType":41,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1340},{"VI":1328},{"title":1342},{"VI":1343},"Daniele Farina",{"id":1345,"sortIndex":99,"researcher":20,"roles":1346,"affiliations":1347,"properties":1356},"73baed90-fb4d-45e1-8358-5d2e5eb1e476",[135],[1348],{"id":20,"sortIndex":21,"affiliation":1349,"properties":20},{"id":1350,"createTime":1351,"updateTime":1351,"relativeEntities":1352,"slug":20,"properties":1353,"entityType":41,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"97a2fb1a-6bf2-4924-b23d-2a7a2df0f2c3","2023-12-25T02:58:25.772+00:00",[],{"title":1354},{"VI":1355},"Hospital Clínico San Borja Arriarán, Santiago, Chile",{"title":1357},{"VI":1358},"Miguel Angel Pantoja Herrera",{"id":1360,"sortIndex":21,"researcher":20,"roles":1361,"affiliations":1362,"properties":1368},"d205b418-df35-4259-bb49-d8bcd8de6820",[135],[1363],{"id":20,"sortIndex":21,"affiliation":1364,"properties":20},{"id":1323,"createTime":1324,"updateTime":1324,"relativeEntities":1365,"slug":20,"properties":1366,"entityType":41,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1367},{"VI":1328},{"title":1369},{"VI":1370},"Paolo 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