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After a nephrostomy was performed, a guide wire was introduced into the intestinal loop through the stenotic portion under direct observation using a ureterorenoscope. Dilation was performed using the Olbert balloon dilator (30‐Fr) inserted along a guide wire into the stenotic portion. A 20‐Fr or 22‐Fr multihole catheter was left for approximately 6 weeks. No major complications were encountered during or after these procedures. After removal of the indwelling catheters, the progress of each patient was followed for at least 14 months.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>\n            \u003Cjats:italic>Results:\u003C\u002Fjats:italic>\n          \u003C\u002Fjats:bold> Additional dilation was necessary in three of 10 patients for the recurrent stricture. The balloon dilation was ineffective in two patients with a long stenosis of the ureter or a previous history of radiation therapy for uterine cancer. Eight of 10 patients showed satisfactory outcomes during the mean follow‐up period of 47.1 months.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>\n            \u003Cjats:italic>Conclusions:\u003C\u002Fjats:italic>\n          \u003C\u002Fjats:bold> Based on these results, we believe that the balloon dilation could be the first line of treatment for strictures of uro‐digestive anastomosis, except for some patients with a long stenosis or a previous history of intrapelvic radiation.\u003C\u002Fjats:p>",{"EN":101},"Long‐term results of percutaneous balloon dilation for ureterointestinal anastomotic strictures",{"VOID":103},"12189603",{"VOID":105},"10.1046\u002Fj.1442-2042.2002.00459_1.x","PUBLICATION","VERIFIED","Auto 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A total of 129 LRN were performed. There were 34 elderly patients (≥70 years) and 95 adult patients (<70 years). The two groups were compared for comorbidity, previous surgical history, operative time, estimated blood loss, tumor size, complications during and after surgery, time to oral intake\u002Fambulation, hospital stay, overall survival and disease free survival rates.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Results: \u003C\u002Fjats:bold> In preoperative comorbid conditions, the number of patients with hypertension\u002Fischemic heart disease in the elderly group was significantly greater than that in the adult group (p = 0.01). The elderly group had a mean operative time (247 min vs. 244 min) and blood loss (120 ml vs. 180 ml) similar to those in the adult group. In addition, the incidence of perioperative complications was not different between the two groups (intra‐op: 2.9% vs. 5.3%\u002F post‐op: 8.8% vs. 4.2%). All other variables before, during and after surgery were compatible between the two groups.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Conclusions: \u003C\u002Fjats:bold> The efficacy and oncological outcome of laparoscopic surgery in elderly patients was as promising as those in their younger counterparts. 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Another 373 women with the same criteria enrolled at \u003Cjats:styled-content style=\"fixed-case\">S\u003C\u002Fjats:styled-content>anta \u003Cjats:styled-content style=\"fixed-case\">C\u003C\u002Fjats:styled-content>hiara \u003Cjats:styled-content style=\"fixed-case\">H\u003C\u002Fjats:styled-content>ospital, \u003Cjats:styled-content style=\"fixed-case\">T\u003C\u002Fjats:styled-content>rento, Italy, from \u003Cjats:styled-content style=\"fixed-case\">J\u003C\u002Fjats:styled-content>anuary 2010 to \u003Cjats:styled-content style=\"fixed-case\">J\u003C\u002Fjats:styled-content>une 2012 were used to externally validate and calibrate the nomogram. Univariate and multivariate \u003Cjats:styled-content style=\"fixed-case\">C\u003C\u002Fjats:styled-content>ox regression models tested the relationship between urinary tract infection recurrence risk, and patient clinical and laboratory characteristics. The nomogram was evaluated by calculating concordance probabilities, as well as testing calibration of predicted urinary tract infection recurrence with observed urinary tract infections. Nomogram variables included: number of partners, bowel function, type of pathogens isolated (\u003Cjats:styled-content style=\"fixed-case\">G\u003C\u002Fjats:styled-content>ram‐positive\u002Fnegative), hormonal status, number of previous urinary tract infection recurrences and previous treatment of asymptomatic bacteriuria.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Of the original development data, 261 out of 768 women presented at least one episode of recurrence of urinary tract infection (33.9%). The nomogram had a concordance index of 0.85. The nomogram predictions were well calibrated. This model showed high discrimination accuracy and favorable calibration characteristics. In the validation group (373 women), the overall c‐index was 0.83 (\u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.003, 95% confidence interval 0.51–0.99), whereas the area under the receiver operating characteristic curve was 0.85 (95% confidence interval 0.79–0.91).\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>The present nomogram accurately predicts the recurrence risk of urinary tract infection at 12 months, and can assist in identifying women at high risk of symptomatic recurrence that can be suitable candidates for a prophylactic strategy.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":1094},"Development and validation of a nomogram predicting recurrence risk in women with symptomatic urinary tract infection",{"VOID":1096},"24725240",{"VOID":1098},"10.1111\u002Fiju.12453",[110],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fiju.12453",[1102,1121,1140,1157,1174,1191,1208,1226,1246,1266],{"id":1103,"sortIndex":25,"researcher":24,"roles":1104,"affiliations":1105,"properties":1114,"displayName":1118,"givenName":24,"familyName":24},"2e2ebc29-cf68-4728-8444-e08cfda90932",[],[1106],{"id":1107,"sortIndex":25,"affiliation":1108,"properties":24},"ff624f38-7a28-4c95-9501-99f709b1a1dc",{"id":1107,"createTime":24,"updateTime":24,"relativeEntities":1109,"slug":24,"properties":1110,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1113,"statistic":24},[],{"title":1111},{"VI":1112},"Department of Urology, Santa Chiara Regional Hospital, Trento, Italy",[],{"orcid":1115,"title":1117,"openalex":1119},{"VOID":1116},"https:\u002F\u002Forcid.org\u002F0000-0002-7234-3526",{"EN":1118},"Tommaso Cai",{"VOID":1120},"A5105471967",{"id":1122,"sortIndex":132,"researcher":24,"roles":1123,"affiliations":1124,"properties":1133,"displayName":1137,"givenName":24,"familyName":24},"927770a2-0b22-42cd-8fec-f1c442838840",[],[1125],{"id":1126,"sortIndex":25,"affiliation":1127,"properties":24},"99846e47-d6a7-4660-ab0c-8ee6f73a8b40",{"id":1126,"createTime":24,"updateTime":24,"relativeEntities":1128,"slug":24,"properties":1129,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1132,"statistic":24},[],{"title":1130},{"EN":1131},"Sexually Transmitted Disease Center Santa Maria Annunziata Hospital Florence Italy",[],{"orcid":1134,"title":1136,"openalex":1138},{"VOID":1135},"https:\u002F\u002Forcid.org\u002F0000-0002-6266-5492",{"EN":1137},"Sandra Mazzoli",{"VOID":1139},"A5087473955",{"id":1141,"sortIndex":148,"researcher":24,"roles":1142,"affiliations":1143,"properties":1152,"displayName":1154,"givenName":24,"familyName":24},"d1858828-6730-4ee7-8d11-eae5d44bbda6",[],[1144],{"id":1145,"sortIndex":25,"affiliation":1146,"properties":24},"71440e3c-0e3f-43fe-9143-6de7ea1458e9",{"id":1145,"createTime":24,"updateTime":24,"relativeEntities":1147,"slug":24,"properties":1148,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1151,"statistic":24},[],{"title":1149},{"VI":1150},"Department of Gynecology and Obstetrics, Santa Chiara Regional Hospital, Trento, Italy",[],{"title":1153,"openalex":1155},{"EN":1154},"Serena Migno",{"VOID":1156},"A5037674145",{"id":1158,"sortIndex":164,"researcher":24,"roles":1159,"affiliations":1160,"properties":1167,"displayName":1171,"givenName":24,"familyName":24},"f41ef216-b85b-4141-8903-a98c7a2b58e0",[],[1161],{"id":1107,"sortIndex":25,"affiliation":1162,"properties":24},{"id":1107,"createTime":24,"updateTime":24,"relativeEntities":1163,"slug":24,"properties":1164,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1166,"statistic":24},[],{"title":1165},{"VI":1112},[],{"orcid":1168,"title":1170,"openalex":1172},{"VOID":1169},"https:\u002F\u002Forcid.org\u002F0000-0001-8766-814X",{"EN":1171},"G. 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This study was conducted in men with a non‐enlarged prostate to determine the cause of urinary disturbance by less invasive examinations that might eventually replace pressure‐flow study.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Methods:\u003C\u002Fjats:bold> Thirty‐six men with lower urinary tract symptoms were enrolled. Their prostate volume, estimated by transrectal ultrasonography, was less than 20 mL. All patients were examined using pressure‐flow study, free‐flowmetry, transrectal ultrasonography, prostate specific antigen and an interview using the International Prostate Symptom Score and Quality of Life Index. With determination of the cause for urinary disturbance, parameters that correlated with outflow obstruction or impaired detrusor contractility were sought.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Results:\u003C\u002Fjats:bold>  Twenty‐one (60%) of the 36 men were judged as having outflow obstruction, and 16 of these 21 men had normal detrusor function. Impaired detrusor contractility was observed in 17 men. Only three of these 17 men had no outflow obstruction. Four patients had an unstable bladder. All these four had normal detrusor contractility, but had outflow obstruction. Among the parameters examined, only the maximum flow rate in a flow metrogram (Q\u003Cjats:sub>max\u003C\u002Fjats:sub>) correlated significantly with the degree of outflow obstruction (\u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.04). The positive predictive value of Q\u003Cjats:sub>max\u003C\u002Fjats:sub> for outflow obstruction was 65% at a flow rate of less than 10 mL\u002Fs, and 100% at that of less than 5 mL\u002Fs. No parameter correlated with detrusor contractility.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Conclusion:\u003C\u002Fjats:bold>  The only parameter that was a clear indicator of outflow obstruction was Q\u003Cjats:sub>max\u003C\u002Fjats:sub>. 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Scand, J. Urol. Nephrol. Suppl., 157, 27",{},{"id":24,"text":1624,"url":24,"identifiers":1625},"10.1111\u002Fj.1464-410X.1994.tb16586.x",{"doi":1624},{"id":24,"text":1627,"url":24,"identifiers":1628},"Barry MJ, 1995, The development and clinical utility of symptom scores, Urol. Clin. North Am., 22, 299, 10.1016\u002FS0094-0143(21)00666-2",{"doi":1629},"10.1016\u002FS0094-0143(21)00666-2",{"id":24,"text":1631,"url":24,"identifiers":1632},"10.1016\u002FS0094-0143(21)00968-X",{"doi":1631},{"id":24,"text":1634,"url":24,"identifiers":1635},"10.1016\u002FS0022-5347(01)64707-4",{"doi":1634},{"id":24,"text":1637,"url":24,"identifiers":1638},"Schäfer W, 1988, The value of free flow rate and pressure\u002Fflow‐studies in the routine investigation of BPH patients, Neurourol. 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North Am., 22, 593",{},{"id":1652,"createTime":1653,"updateTime":1653,"relativeEntities":1654,"slug":1655,"properties":1656,"entityType":106,"verifyStatus":107,"verifyTime":1669,"verifyNote":108,"languages":1670,"translateLanguages":24,"viewCount":25,"primaryUrl":1671,"fullTextUrl":24,"authors":1672,"publicationType":214,"publisherRelationship":1737,"citationCount":1782,"citationInfo":1783,"publishDate":1786,"publishYear":263,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":1787,"openAccess":24,"references":1788,"isForceReanalyzing":312},"d192a11e-104a-4044-a791-d33c17c4cffe","2024-12-14T10:28:52.468+00:00",[],"Effects-of-bladder-volume-on-transabdominal-ultrasound-measurements-of-intravesical-prostatic-protrusion-and-volume",{"openalex":1657,"mag":1659,"abstract":1661,"title":1663,"pm":1665,"doi":1667},{"VOID":1658},"W2033067773",{"VOID":1660},"2033067773",{"EN":1662},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p> \u003Cjats:bold>\n            \u003Cjats:italic>Background\u003C\u002Fjats:italic>:\u003C\u002Fjats:bold> A filled bladder acts as an acoustic window for transabdominal ultrasound measurements of intravesical prostatic protrusion and volume. The aim of this study is to evaluate the effects of bladder volume on transabdominal ultrasound measurements of these parameters.\u003C\u002Fjats:p>\u003Cjats:p> \u003Cjats:bold>\n            \u003Cjats:italic>Methods\u003C\u002Fjats:italic>:\u003C\u002Fjats:bold> Twenty‐two patients undergoing transurethral resection of the prostate (TURP) were studied. Under general anesthesia just before TURP, a transrectal ultrasound measurement of prostate volume was obtained. The bladder was then filled in a stepwise manner with 100, 200, 300, 400 and 500 mL. At each volume, the intravesical prostatic protrusion and prostatic volume were measured transabdominally using ultrasound.\u003C\u002Fjats:p>\u003Cjats:p> \u003Cjats:bold>\n            \u003Cjats:italic>Results\u003C\u002Fjats:italic>:\u003C\u002Fjats:bold> There was an obvious trend of decreasing mean transabdominal intravesical prostatic protrusions with increasing bladder volume. The mean transabdominal intravesical prostatic protrusion at bladder volumes 100, 200, 300, 400 and 500 mL was 9.1, 8.8, 7.4, 5.8 and 4.6 mm, respectively. The bladder volume at which maximum prostatic protrusion occurred was between 100 and 200 mL. The mean transabdominal prostate volume at the five increasing bladder volumes was 50.6, 48.7, 49.2, 47.9 and 41.4 mL, and these were correlated to transrectal prostate volume, particularly when the bladder volume was less than 400 mL.\u003C\u002Fjats:p>\u003Cjats:p> \u003Cjats:bold>\n            \u003Cjats:italic>Conclusions\u003C\u002Fjats:italic>:\u003C\u002Fjats:bold> Transabdominal ultrasound measurement of prostatic protrusion is dependent on bladder volume. Transabdominal ultrasound measurement of prostatic volume correlates well with the transrectal measurement of the same parameter when the bladder volume is less than 400 mL.\u003C\u002Fjats:p>",{"EN":1664},"Effects of bladder volume on transabdominal ultrasound measurements of intravesical prostatic protrusion and volume",{"VOID":1666},"12010318",{"VOID":1668},"10.1046\u002Fj.1442-2042.2002.00453.x","2024-12-14T10:28:52.467+00:00",[110],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1046\u002Fj.1442-2042.2002.00453.x",[1673,1692,1707,1722],{"id":1674,"sortIndex":25,"researcher":24,"roles":1675,"affiliations":1676,"properties":1685,"displayName":1689,"givenName":24,"familyName":24},"22390b5b-3011-4507-91c3-9906265c7012",[],[1677],{"id":1678,"sortIndex":25,"affiliation":1679,"properties":24},"16d81af4-63d8-43de-8fe0-f3adf93096ce",{"id":1678,"createTime":24,"updateTime":24,"relativeEntities":1680,"slug":24,"properties":1681,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1684,"statistic":24},[],{"title":1682},{"VI":1683},"Department of Urology, Singapore General Hospital, Singapore",[],{"orcid":1686,"title":1688,"openalex":1690},{"VOID":1687},"https:\u002F\u002Forcid.org\u002F0000-0002-6367-2563",{"EN":1689},"John Shyi Peng Yuen",{"VOID":1691},"A5061784402",{"id":1693,"sortIndex":132,"researcher":24,"roles":1694,"affiliations":1695,"properties":1702,"displayName":1704,"givenName":24,"familyName":24},"022bf0dd-f6d2-457e-bfda-cdcf82d53512",[],[1696],{"id":1678,"sortIndex":25,"affiliation":1697,"properties":24},{"id":1678,"createTime":24,"updateTime":24,"relativeEntities":1698,"slug":24,"properties":1699,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1701,"statistic":24},[],{"title":1700},{"VI":1683},[],{"title":1703,"openalex":1705},{"EN":1704},"James Tan Khiaw 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K, 1985, Development and clinical significance of protrusion of hypertrophic prostate into the bladder observed by transrectal ultrasonotomography, Jpn. J. Urol., 76, 1194, 10.5980\u002Fjpnjurol1928.76.8_1194",{"doi":1792},"10.5980\u002Fjpnjurol1928.76.8_1194",{"id":24,"text":1794,"url":24,"identifiers":1795},"10.1002\u002F(sici)1097-0045(19981001)37:2\u003C116::aid-pros8>3.0.co;2-e",{"doi":1794},{"id":24,"text":1797,"url":24,"identifiers":1798},"Mebust WK, 1993, Proceedings of the 2nd International Consultation in Benign Prostatic Hyperplasia (BPH), June 27–30 1993, Paris., 131",{},{"id":24,"text":1800,"url":24,"identifiers":1801},"10.1016\u002Fs0090-4295(98)00020-x",{"doi":1800},{"id":24,"text":1803,"url":24,"identifiers":1804},"10.1016\u002FS0022-5347(01)65178-4",{"doi":1803},{"id":24,"text":1806,"url":24,"identifiers":1807},"10.1016\u002FS0022-5347(01)63723-6",{"doi":1806},{"id":1809,"createTime":1810,"updateTime":1810,"relativeEntities":1811,"slug":1812,"properties":1813,"entityType":106,"verifyStatus":107,"verifyTime":1826,"verifyNote":108,"languages":1827,"translateLanguages":24,"viewCount":25,"primaryUrl":1828,"fullTextUrl":24,"authors":1829,"publicationType":214,"publisherRelationship":1911,"citationCount":1957,"citationInfo":1958,"publishDate":1962,"publishYear":1959,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":1963,"openAccess":24,"references":1964,"isForceReanalyzing":312},"14ebe043-3e51-4abf-9a15-669d983da504","2024-12-14T10:28:50.753+00:00",[],"Intravesical-prostatic-protrusion-predicts-clinical-progression-of-benign-prostatic-enlargement-in-patients-receiving-medical-treatment",{"openalex":1814,"mag":1816,"abstract":1818,"title":1820,"pm":1822,"doi":1824},{"VOID":1815},"W1653268791",{"VOID":1817},"1653268791",{"EN":1819},"\u003Cjats:p>\u003Cjats:bold>Objectives: \u003C\u002Fjats:bold> To assess intravesical prostatic protrusion (IPP) as a novel predictor of clinical progression in patients with benign prostatic enlargement (BPE).\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Methods: \u003C\u002Fjats:bold> All patients attending the outpatient clinic at our institution who were being treated for lower urinary tract symptoms (LUTS) secondary to BPE between January 1997 and December 2003 were recruited into the study. International Prostate Symptom Score (IPSS) scores, uroflowmetry parameters, post‐void residual urine volume (PVR), IPP and serum prostate‐specific antigen (PSA) were collected. IPP was classified into Grade 1, 2 or 3. Patients were stratified to different treatment options including watchful waiting, alpha blockers or 5‐alpha reductase inhibitors. Those who developed high post‐void residual urine volume (>100 mL), acute urinary retention or a deterioration of at least 4 points in IPSS score were considered to have disease progression. Using the Grade 1 IPP group as a reference, the odds ratio for clinical progression of Grade 2 and Grade 3 IPP were calculated by using multivariate analysis.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Results: \u003C\u002Fjats:bold> A total of 259 patients with a mean age of 63 years (range 50–90 years) and mean follow‐up time of 32 months were available for analysis. Fifty‐two patients were found to have clinical progression. Odds ratio for progression of a Grade 2 IPP was 5.1 (95% confidence interval [CI] 1.6–16.2) and that of a Grade 3 IPP was 10.4 (95% CI 3.3–33.4).\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Conclusion: \u003C\u002Fjats:bold> A higher IPP grade is associated with a higher risk of clinical progression in BPE. IPP is a useful non‐invasive predictor for clinical progression in BPE.\u003C\u002Fjats:p>",{"EN":1821},"Intravesical prostatic protrusion predicts clinical progression of benign prostatic enlargement in patients receiving medical 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MK, 2007, An Asian multinational prospective observational registry of patients with benign prostatic hyperplasia, with a focus on comorbidities, lower urinary tract symptoms and sexual function, BJU Int, 101, 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1931, Surgical Pathology of Prostatic Obstruction",{},{"id":24,"text":2001,"url":24,"identifiers":2002},"10.1111\u002Fj.1442-2042.2006.01611.x",{"doi":2001},{"id":24,"text":2004,"url":24,"identifiers":2005},"10.1016\u002FS0090-4295(98)00020-X",{"doi":2004},{"id":24,"text":2007,"url":24,"identifiers":2008},"10.1080\u002F00365590310014760",{"doi":2007},{"id":24,"text":2010,"url":24,"identifiers":2011},"10.1016\u002FS0022-5347(01)66780-6",{"doi":2010},{"id":24,"text":2013,"url":24,"identifiers":2014},"10.1111\u002Fj.1464-410X.1995.tb07421.x",{"doi":2013},{"id":24,"text":2016,"url":24,"identifiers":2017},"10.1056\u002FNEJMoa030656",{"doi":2016},{"id":2019,"createTime":2020,"updateTime":2020,"relativeEntities":2021,"slug":2022,"properties":2023,"entityType":106,"verifyStatus":107,"verifyTime":2020,"verifyNote":108,"languages":2035,"translateLanguages":24,"viewCount":25,"primaryUrl":2036,"fullTextUrl":24,"authors":2037,"publicationType":214,"publisherRelationship":2115,"citationCount":2161,"citationInfo":2162,"publishDate":2166,"publishYear":2163,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":2167,"openAccess":24,"references":2168,"isForceReanalyzing":312},"14f0484e-2aa9-463c-b95a-77f9f60d6ccb","2024-12-14T10:28:46.821+00:00",[],"Comparison-of-intravesical-prostatic-protrusion-prostate-volume-and-serum-prostatic-specific-antigen-in-the-evaluation-of-bladder-outlet-obstruction",{"openalex":2024,"mag":2026,"abstract":2028,"title":2030,"pm":2032,"doi":2034},{"VOID":2025},"W2322978098",{"VOID":2027},"2322978098",{"EN":2029},"\u003Cjats:p>\u003Cjats:bold>Aim:\u003C\u002Fjats:bold> The aims of this study were to define the relationship between intravesical prostatic protrusion (IPP), prostate‐specific antigen (PSA) and prostate volume (PV) and to determine which one of them is the best predictor of bladder outlet obstruction (BOO) due to benign prostatic enlargement.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Methods:\u003C\u002Fjats:bold> A prospective study of 114 male patients older than 50 years examined between November 2001 and 2002 was performed. They were evaluated with digital rectal examination, International Prostate Symptoms Score, PSA, uroflowmetry, postvoid residual urine measurement, IPP and PV using transabdominal ultrasound scan. Statistical analysis included scatter plot with Spearman’s correlation coefficients and nominal logistic regression\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Results:\u003C\u002Fjats:bold> Prostate volume, IPP and PSA showed parallel correlation. Although all three indices had good correlation with BOO index, IPP was the best. The Spearman rho correlation coefficients were 0.314, 0.408 and 0.507 for PV, PSA and IPP, respectively. Using receiver‐operator characteristic curves, the areas under the curve for PV, PSA and IPP were 0.637, 0.703 and 0.772, respectively. The positive predictive values of PV, PSA and IPP were 65%, 68% and 72%, respectively. Using a nominal regression model, IPP remained the most significant independent index to determine BOO.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Conclusions:\u003C\u002Fjats:bold> All three non‐invasive indices correlate with one another. The study showed that IPP is a better predictor for BOO than PSA or PV.\u003C\u002Fjats:p>",{"EN":2031},"Comparison of intravesical prostatic protrusion, prostate volume and serum prostatic‐specific antigen in the evaluation of bladder outlet 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The \u003Cjats:styled-content style=\"fixed-case\">GLOBOCAN\u003C\u002Fjats:styled-content> project showed that prostate cancer was the second most frequently diagnosed cancer and the fifth leading cause of cancer mortality among men worldwide in 2012. This trend has been growing even in Asian countries, where the incidence had previously been low. However, the accuracy of data about incidence and mortality as a result of prostate cancer in some Asian countries is limited. The cause of this increasing trend is multifactorial. One possible explanation is changes in lifestyles due to more Westernized diets. The incidence is also statistically biased by the wide implementation of early detection systems and the accuracy of national cancer registration systems, which are still immature in most Asian countries. Mortality rate decreases in Australia, New Zealand and Japan since the 1990s are possibly due to the improvements in treatment and\u002For early detection efforts employed. However, this rate is increasing in the majority of other Asian countries. Studies of latent and incidental prostate cancer provide less biased information. The prevalence of latent and incidental prostate cancer in contemporary Japan and Korea is similar to those in Western countries, suggesting the influence of lifestyle changes on carcinogenesis. Many studies reported evidence of both congenital and acquired risk factors for carcinogenesis of prostate cancer. Recent changes in the acquired risk factors might be associated with the increasing occurrence of prostate cancer in Asian countries. This trend could continue, especially in developing Asian countries.\u003C\u002Fjats:p>",{"EN":2244},"Epidemiology of prostate cancer in Asian countries",{"VOID":2246},"29740894",{"VOID":2248},"10.1111\u002Fiju.13593",[110],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fiju.13593",[2252,2271],{"id":2253,"sortIndex":25,"researcher":24,"roles":2254,"affiliations":2255,"properties":2264,"displayName":2268,"givenName":24,"familyName":24},"cc503431-2d33-4dc4-a8ab-a883e9714b13",[],[2256],{"id":2257,"sortIndex":25,"affiliation":2258,"properties":24},"6636e0f3-1ec0-42d7-9210-ffceb648d1a2",{"id":2257,"createTime":24,"updateTime":24,"relativeEntities":2259,"slug":24,"properties":2260,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2263,"statistic":24},[],{"title":2261},{"VI":2262},"Department of Urology, Jikei University School of Medicine, Tokyo, 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2012: Estimated Cancer Incidence Mortality and Prevalence Worldwide in 2012. 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Urol., 169, 1589",{},{"id":24,"text":2626,"url":24,"identifiers":2627},"10.1677\u002FERC-09-0087",{"doi":2626},{"id":24,"text":2629,"url":24,"identifiers":2630},"10.1158\u002F1055-9965.EPI-06-0410",{"doi":2629},{"id":24,"text":2632,"url":24,"identifiers":2633},"10.1038\u002Fpcan.2012.40",{"doi":2632},{"id":24,"text":2635,"url":24,"identifiers":2636},"10.1002\u002Fijc.28989",{"doi":2635},{"id":24,"text":2638,"url":24,"identifiers":2639},"10.1016\u002Fj.urolonc.2012.07.008",{"doi":2638},{"id":24,"text":2641,"url":24,"identifiers":2642},"10.7314\u002FAPJCP.2012.13.8.4097",{"doi":2641},{"id":2644,"createTime":2645,"updateTime":2645,"relativeEntities":2646,"slug":2647,"properties":2648,"entityType":106,"verifyStatus":107,"verifyTime":2645,"verifyNote":108,"languages":2661,"translateLanguages":24,"viewCount":25,"primaryUrl":2662,"fullTextUrl":24,"authors":2663,"publicationType":214,"publisherRelationship":2785,"citationCount":2831,"citationInfo":2832,"publishDate":2836,"publishYear":2833,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":2837,"openAccess":24,"references":2838,"isForceReanalyzing":312},"62e94e6a-57b6-4fa7-8190-f0b302dd407f","2024-12-06T11:38:48.902+00:00",[],"Evaluation-of-reference-genes-for-the-analysis-of-serum-miRNA-in-patients-with-prostate-cancer-bladder-cancer-and-renal-cell-carcinoma",{"openalex":2649,"mag":2651,"abstract":2653,"title":2655,"pm":2657,"doi":2659},{"VOID":2650},"W1580162678",{"VOID":2652},"1580162678",{"EN":2654},"\u003Cjats:p>\u003Cjats:bold>Objectives: \u003C\u002Fjats:bold> To identify an appropriate reference gene for the analysis of circulating micro‐ribonucleic acid in patients with urological malignancies.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Methods: \u003C\u002Fjats:bold> Serum from patients with prostate cancer (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 24), bladder cancer (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 24), renal cell carcinoma (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 24) and control subjects (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 48) was spiked with cel‐miR‐39, and then ribonucleic acid was isolated. Quantitative real‐time polymerase chain reaction was used to determine the levels of candidate reference genes (\u003Cjats:italic>RNU1‐4\u003C\u002Fjats:italic>, \u003Cjats:italic>RNU6‐2\u003C\u002Fjats:italic>, \u003Cjats:italic>SNORD43\u003C\u002Fjats:italic>, \u003Cjats:italic>SNORD44\u003C\u002Fjats:italic>, \u003Cjats:italic>SNORD48\u003C\u002Fjats:italic>, S\u003Cjats:italic>NORA74A\u003C\u002Fjats:italic>, \u003Cjats:italic>miR‐let‐7a‐1\u003C\u002Fjats:italic>, \u003Cjats:italic>miR‐106a\u003C\u002Fjats:italic>). Reference gene stability was determined using the NormFinder, geNorm and comparative delta‐Ct algorithm. The effect of normalization was tested with miR‐21 as the target gene, as this was previously suggested to be upregulated in cancer patients' serum.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Results: \u003C\u002Fjats:bold> Recovery of cel‐miR‐39 (mean 11.6%, range 1–56%) was similar in control subjects and cancer patients. \u003Cjats:italic>SNORD44\u003C\u002Fjats:italic> and \u003Cjats:italic>SNORD74A\u003C\u002Fjats:italic> levels were around the detection limit of the assay and were thus omitted. All remaining candidates showed satisfying stability; \u003Cjats:italic>SNORD43\u003C\u002Fjats:italic> was the most stable reference gene using all three algorithms. A combination of two genes (\u003Cjats:italic>SNORD43\u003C\u002Fjats:italic>, \u003Cjats:italic>RNU1‐4\u003C\u002Fjats:italic>) increases the stability somewhat. The level of miR‐21 was similar in cancer patients and healthy controls, irrespective of the normalization strategy.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Conclusions: \u003C\u002Fjats:bold>  \u003Cjats:italic>SNORD43\u003C\u002Fjats:italic> is a suitable reference gene for the analysis of circulating micro‐ribonucleic acid in patients with urological malignancies. 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