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Immunol., 11, 508, 10.3389\u002Ffimmu.2020.00508",{"doi":852},"10.3389\u002Ffimmu.2020.00508",false,{"id":855,"createTime":856,"updateTime":857,"relativeEntities":858,"slug":859,"properties":860,"entityType":172,"verifyStatus":173,"verifyTime":856,"verifyNote":174,"languages":876,"translateLanguages":877,"viewCount":25,"primaryUrl":878,"fullTextUrl":24,"authors":879,"publicationType":290,"publisherRelationship":916,"citationCount":995,"citationInfo":996,"publishDate":24,"publishYear":24,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":998,"openAccess":24,"references":999,"isForceReanalyzing":853},"e80d8cdd-3f7b-41f9-9550-89c3f5f93f23","2024-10-16T03:13:53.336+00:00","2026-09-06T08:12:32.435+00:00",[],"The-Role-of-Dicer-in-DNA-Damage-Repair",{"mag":861,"pmc":863,"openalex":865,"abstract":867,"title":869,"pm":872,"doi":874},{"VOID":862},"2001204753",{"VOID":864},"3546719",{"VOID":866},"W2001204753",{"EN":868},"\u003Cjats:p>Dicer is the key component of the RNA interference pathway. 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Res, 717, 54, 10.1016\u002Fj.mrfmmm.2011.03.012",{"doi":1282},"10.1016\u002Fj.mrfmmm.2011.03.012",{"id":24,"text":1284,"url":24,"identifiers":1285},"Wu, 2012, MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1, Carcinogenesis, 33, 519, 10.1093\u002Fcarcin\u002Fbgr304",{"doi":1286},"10.1093\u002Fcarcin\u002Fbgr304",{"id":1288,"createTime":1289,"updateTime":1290,"relativeEntities":1291,"slug":1292,"properties":1293,"entityType":172,"verifyStatus":173,"verifyTime":1309,"verifyNote":174,"languages":1310,"translateLanguages":1311,"viewCount":25,"primaryUrl":1312,"fullTextUrl":24,"authors":1313,"publicationType":290,"publisherRelationship":1514,"citationCount":1593,"citationInfo":1594,"publishDate":24,"publishYear":24,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":1598,"openAccess":24,"references":1599,"isForceReanalyzing":853},"6e818988-4095-4982-b9ab-0ed2c639799c","2024-11-25T07:10:13.518+00:00","2026-09-05T13:12:57.462+00:00",[],"Synthesis-DNA-Binding-and-Antiproliferative-Activity-of-Novel-Acridine-Thiosemicarbazone-Derivatives",{"mag":1294,"pmc":1296,"openalex":1298,"abstract":1300,"title":1302,"pm":1305,"doi":1307},{"VOID":1295},"1598392272",{"VOID":1297},"4490484",{"VOID":1299},"W1598392272",{"EN":1301},"\u003Cjats:p>In this work, the acridine nucleus was used as a lead-compound for structural modification by adding different substituted thiosemicarbazide moieties. Eight new  (Z)-2-(acridin-9-ylmethylene)-N-phenylhydrazinecarbothioamide derivatives (3a–h) were synthesized, their antiproliferative activities were evaluated, and DNA binding properties were performed with calf thymus DNA (ctDNA) by electronic absorption and fluorescence spectroscopies. Both hyperchromic and hypochromic effects, as well as red or blue shifts were demonstrated by addition of ctDNA to the derivatives. The calculated binding constants ranged from 1.74 × 104 to 1.0 × 106 M−1 and quenching constants from  −0.2 × 104 to 2.18 × 104 M−1 indicating high affinity to ctDNA base pairs. The most efficient compound in binding to ctDNA in vitro was (Z)-2-(acridin-9-ylmethylene)-N- (4-chlorophenyl) hydrazinecarbothioamide (3f), while the most active compound in antiproliferative assay was (Z)-2-(acridin-9-ylmethylene)-N-phenylhydrazinecarbothioamide (3a). There was no correlation between DNA-binding and in vitro antiproliferative activity, but the results suggest that DNA binding can be involved in the biological activity mechanism. This study may guide the choice of the size and shape of the intercalating part of the ligand and the strategic selection of substituents that increase DNA-binding or antiproliferative properties.\u003C\u002Fjats:p>",{"EN":1303,"VI":1304},"Synthesis, DNA Binding, and Antiproliferative Activity of Novel Acridine-Thiosemicarbazone Derivatives","Tổng hợp, gắn kết DNA và hoạt tính kháng tăng sinh của các dẫn xuất acridine-thiosemicarbazone 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Long non-coding RNAs (lncRNAs) have a crucial role in regulating gene expression and in epigenetics (chromatin and histones remodeling). LncRNAs may have different roles: gene activators (signaling), repressors (decoy), cis and trans gene expression regulators (guides) and chromatin modificators (scaffolds) without the need to be mutually exclusive. LncRNAs are also implicated in a number of diseases. The huge amount of inhomogeneous data produced so far poses several bioinformatics challenges spanning from the simple annotation to the more complex functional annotation. In this review, we report and discuss several bioinformatics resources freely available and dealing with the study of lncRNAs. To our knowledge, this is the first review summarizing all the available bioinformatics resources on lncRNAs appeared in the literature after the completion of the human genome project. Therefore, the aim of this review is to provide a little guide for biologists and bioinformaticians looking for dedicated resources, public repositories and other tools for lncRNAs functional analysis.\u003C\u002Fjats:p>",{"EN":1822,"VI":1823},"Bioinformatics Tools and Novel Challenges in Long Non-Coding RNAs (lncRNAs) Functional Analysis","Các công cụ tin sinh học và những thách thức mới trong phân tích chức năng của RNA không mã hóa dài 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Methods, 5, 613, 10.1038\u002Fnmeth.1223",{"doi":2295},"10.1038\u002Fnmeth.1223",{"id":2297,"createTime":2298,"updateTime":2299,"relativeEntities":2300,"slug":2301,"properties":2302,"entityType":172,"verifyStatus":173,"verifyTime":2298,"verifyNote":174,"languages":2318,"translateLanguages":2319,"viewCount":25,"primaryUrl":2320,"fullTextUrl":24,"authors":2321,"publicationType":290,"publisherRelationship":2444,"citationCount":2523,"citationInfo":2524,"publishDate":24,"publishYear":24,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":2532,"openAccess":24,"references":2533,"isForceReanalyzing":853},"95cb4102-e1a1-464f-b53d-a303e2e601bf","2024-10-15T17:57:07.910+00:00","2026-09-05T05:14:21.254+00:00",[],"Mesenchymal-Stem-Cells-Cell-Fate-Decision-to-Osteoblast-or-Adipocyte-and-Application-in-Osteoporosis-Treatment",{"mag":2303,"pmc":2305,"openalex":2307,"abstract":2309,"title":2311,"pm":2314,"doi":2316},{"VOID":2304},"2793880258",{"VOID":2306},"5855582",{"VOID":2308},"W2793880258",{"EN":2310},"\u003Cjats:p>Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and degraded bone microstructure, which leads to increased bone fragility and risks of bone fracture. Osteoporosis is generally age related and has become a major disease of the world. Uncovering the molecular mechanisms underlying osteoporosis and developing effective prevention and therapy methods has great significance for human health. Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into osteoblasts, adipocytes, or chondrocytes, and have become the favorite source of cell-based therapy. Evidence shows that during osteoporosis, a shift of the cell differentiation of MSCs to adipocytes rather than osteoblasts partly contributes to osteoporosis. Thus, uncovering the molecular mechanisms of the osteoblast or adipocyte differentiation of MSCs will provide more understanding of MSCs and perhaps new methods of osteoporosis treatment. The MSCs have been applied to both preclinical and clinical studies in osteoporosis treatment. Here, we review the recent advances in understanding the molecular mechanisms regulating osteoblast differentiation and adipocyte differentiation of MSCs and highlight the therapeutic application studies of MSCs in osteoporosis treatment. This will provide researchers with new insights into the development and treatment of osteoporosis.\u003C\u002Fjats:p>",{"EN":2312,"VI":2313},"Mesenchymal Stem Cells: Cell Fate Decision to Osteoblast or Adipocyte and Application in Osteoporosis Treatment","Tế bào gốc trung mô: quyết định số phận tế bào thành tạo cốt bào hoặc tế bào mỡ và ứng dụng trong điều trị loãng xương",{"VOID":2315},"29370110",{"VOID":2317},"10.3390\u002Fijms19020360",[176],[178],"https:\u002F\u002Fwww.mdpi.com\u002F1422-0067\u002F19\u002F2\u002F360",[2322,2341,2360,2379,2398,2425],{"id":2323,"sortIndex":25,"researcher":24,"roles":2324,"affiliations":2325,"properties":2334,"displayName":2338,"givenName":24,"familyName":24},"61ebd262-2a9f-40f0-b29f-f067a2216004",[],[2326],{"id":2327,"sortIndex":25,"affiliation":2328,"properties":24},"114839c1-6e5c-42d0-8beb-56640536af7a",{"id":2327,"createTime":24,"updateTime":24,"relativeEntities":2329,"slug":24,"properties":2330,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2333,"statistic":24},[],{"title":2331},{"EN":2332},"Laboratory for Bone Metabolism, Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China. hulifang@nwpu.edu.cn.",[],{"orcid":2335,"title":2337,"openalex":2339},{"VOID":2336},"https:\u002F\u002Forcid.org\u002F0000-0003-1648-4428",{"EN":2338},"Lifang Hu",{"VOID":2340},"A5101529753",{"id":2342,"sortIndex":138,"researcher":24,"roles":2343,"affiliations":2344,"properties":2353,"displayName":2357,"givenName":24,"familyName":24},"8fe08c33-8e7b-4514-9520-af4fde9a12a1",[],[2345],{"id":2346,"sortIndex":25,"affiliation":2347,"properties":24},"c2105499-b609-48ae-bbbc-150b5f57de78",{"id":2346,"createTime":24,"updateTime":24,"relativeEntities":2348,"slug":24,"properties":2349,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2352,"statistic":24},[],{"title":2350},{"EN":2351},"Laboratory for Bone Metabolism, Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China. yinchong42@mail.nwpu.edu.cn.",[],{"orcid":2354,"title":2356,"openalex":2358},{"VOID":2355},"https:\u002F\u002Forcid.org\u002F0000-0002-8113-8911",{"EN":2357},"Chong Yin",{"VOID":2359},"A5100430565",{"id":2361,"sortIndex":139,"researcher":24,"roles":2362,"affiliations":2363,"properties":2372,"displayName":2376,"givenName":24,"familyName":24},"d18ea68a-d2de-45e9-91c4-870e99faee4c",[],[2364],{"id":2365,"sortIndex":25,"affiliation":2366,"properties":24},"9a2c987c-24ec-42d0-b147-1b0296852442",{"id":2365,"createTime":24,"updateTime":24,"relativeEntities":2367,"slug":24,"properties":2368,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2371,"statistic":24},[],{"title":2369},{"EN":2370},"Laboratory for Bone Metabolism, Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China. sofan@mail.nwpu.edu.cn.",[],{"orcid":2373,"title":2375,"openalex":2377},{"VOID":2374},"https:\u002F\u002Forcid.org\u002F0000-0002-9265-1649",{"EN":2376},"Fan Zhao",{"VOID":2378},"A5101571093",{"id":2380,"sortIndex":238,"researcher":24,"roles":2381,"affiliations":2382,"properties":2391,"displayName":2395,"givenName":24,"familyName":24},"d70cf396-33d7-43c7-aadb-adf05252eab4",[],[2383],{"id":2384,"sortIndex":25,"affiliation":2385,"properties":24},"61b75246-a2ca-4bda-9c29-f2b671369ac6",{"id":2384,"createTime":24,"updateTime":24,"relativeEntities":2386,"slug":24,"properties":2387,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2390,"statistic":24},[],{"title":2388},{"EN":2389},"Laboratory for Bone Metabolism, Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China. 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Res., 24, 837, 10.1359\u002Fjbmr.081257",{"doi":3067},"10.1359\u002Fjbmr.081257",{"id":24,"text":3069,"url":24,"identifiers":3070},"Kumar, 2007, Bone homing of mesenchymal stem cells by ectopic α4 integrin expression, FASEB J., 21, 3917, 10.1096\u002Ffj.07-8275com",{"doi":3071},"10.1096\u002Ffj.07-8275com",{"id":24,"text":3073,"url":24,"identifiers":3074},"Liu, 2013, Molecular basis of immortalization of human mesenchymal stem cells by combination of p53 knockdown and human telomerase reverse transcriptase overexpression, Stem Cells Dev., 22, 268, 10.1089\u002Fscd.2012.0222",{"doi":3075},"10.1089\u002Fscd.2012.0222",{"id":24,"text":3077,"url":24,"identifiers":3078},"Fierro, 2011, Effects on proliferation and differentiation of multipotent bone marrow stromal cells engineered to express growth factors for combined cell and gene therapy, Stem Cells, 29, 1727, 10.1002\u002Fstem.720",{"doi":3079},"10.1002\u002Fstem.720",{"id":24,"text":3081,"url":24,"identifiers":3082},"Kong, F., Shi, X., Xiao, F., Yang, Y., Zhang, X., Wang, L.S., Wu, C.T., and Wang, H. (2017). Transplantation of hepatocyte growth factor-modified dental pulp stem cells prevents bone loss in the early phase of ovariectomy-induced osteoporosis. Hum. Gene Ther.",{"doi":3083},"10.1089\u002Fhum.2017.091",{"id":24,"text":3085,"url":24,"identifiers":3086},"Tsai, 2012, Benefits of hypoxic culture on bone marrow multipotent stromal cells, Am. J. 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However, the therapeutic effects of BCP on atopic dermatitis (AD) remain poorly understood. The current study aimed to evaluate the topical therapeutic efficacy of BCP in an AD-like mouse model. Thymic Stromal Lymphopoietin (TSLP) is a keratinocyte-derived cytokine that drives AD pathogenesis. This study also investigated the effect of BCP on the interleukin 4 (IL-4)-induced expression of TSLP in HaCaT keratinocytes. We found that the topical application of BCP alleviated AD-like skin inflammation and inhibited the infiltration of proinflammatory cells into skin lesions. Moreover, the topical application of BCP reduced EGR1 (Early Growth Response 1) and TSLP expression in AD-like skin lesions. We also found that BCP inhibited IL-4-induced TSLP expression by downregulating mitogen-activated protein kinase (MAPK)-mediated EGR1 expression in HaCaT keratinocytes. These findings demonstrate that BCP ameliorates DNCB-induced AD-like skin lesions through the downregulation of the MAPK\u002FEGR1\u002FTSLP signaling axis. 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2016, Atopic Dermatitis, Lancet, 387, 1109, 10.1016\u002FS0140-6736(15)00149-X",{"doi":3318},"10.1016\u002FS0140-6736(15)00149-X",{"id":24,"text":3320,"url":24,"identifiers":3321},"Werfel, 2016, Cellular and Molecular Immunologic Mechanisms in Patients with Atopic Dermatitis, J. Allergy Clin. Immunol., 138, 336, 10.1016\u002Fj.jaci.2016.06.010",{"doi":3322},"10.1016\u002Fj.jaci.2016.06.010",{"id":24,"text":3324,"url":24,"identifiers":3325},"Chan, 2001, Expression of Interleukin-4 in the Epidermis of Transgenic Mice Results in a Pruritic Inflammatory Skin Disease: An Experimental Animal Model to Study Atopic Dermatitis, J. Investig. Dermatol., 117, 977, 10.1046\u002Fj.0022-202x.2001.01484.x",{"doi":3326},"10.1046\u002Fj.0022-202x.2001.01484.x",{"id":24,"text":3328,"url":24,"identifiers":3329},"Trier, 2018, Cytokine Modulation of Atopic Itch, Curr. Opin. Immunol., 54, 7, 10.1016\u002Fj.coi.2018.05.005",{"doi":3330},"10.1016\u002Fj.coi.2018.05.005",{"id":24,"text":3332,"url":24,"identifiers":3333},"Soumelis, 2002, Human Epithelial Cells Trigger Dendritic Cell Mediated Allergic Inflammation by Producing Tslp, Nat. 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Pharmacol., 66, 129, 10.1016\u002FB978-0-12-404717-4.00004-4",{"doi":3374},"10.1016\u002FB978-0-12-404717-4.00004-4",{"id":24,"text":3376,"url":24,"identifiers":3377},"Gertsch, 2008, Antiinflammatory Cannabinoids in Diet–Towards a Better Understanding of Cb2 Receptor Action? Towards a Better Understanding of Cb2 Receptor Action?, Commun. Integr. Biol., 1, 26, 10.4161\u002Fcib.1.1.6568",{"doi":3378},"10.4161\u002Fcib.1.1.6568",{"id":24,"text":3380,"url":24,"identifiers":3381},"Demuth, 2006, Cannabinoid Signalling, Life Sci., 78, 549, 10.1016\u002Fj.lfs.2005.05.055",{"doi":3382},"10.1016\u002Fj.lfs.2005.05.055",{"id":24,"text":3384,"url":24,"identifiers":3385},"Gertsch, 2008, Beta-Caryophyllene Is a Dietary Cannabinoid, Proc. Natl. Acad. Sci. USA, 105, 9099, 10.1073\u002Fpnas.0803601105",{"doi":3386},"10.1073\u002Fpnas.0803601105",{"id":24,"text":3388,"url":24,"identifiers":3389},"Cho, 2007, Amelioration of Dextran Sulfate Sodium-Induced Colitis in Mice by Oral Administration of Β-Caryophyllene, a Sesquiterpene, Life Sci., 80, 932, 10.1016\u002Fj.lfs.2006.11.038",{"doi":3390},"10.1016\u002Fj.lfs.2006.11.038",{"id":24,"text":3392,"url":24,"identifiers":3393},"Zhang, 2021, Β-Caryophyllene Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Inhibition of the Mapk Signalling Pathway, J. Pharm. Pharmacol., 73, 1319, 10.1093\u002Fjpp\u002Frgab074",{"doi":3394},"10.1093\u002Fjpp\u002Frgab074",{"id":24,"text":3396,"url":24,"identifiers":3397},"Ando, 2013, Mast Cells Are Required for Full Expression of Allergen\u002FSeb-Induced Skin Inflammation, J. Investig. 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Biol., 60, 159, 10.1002\u002Fjlb.60.2.159",{"doi":3410},"10.1002\u002Fjlb.60.2.159",{"id":24,"text":3412,"url":24,"identifiers":3413},"Yeo, 2021, Disrupting the DNA Binding of Egr-1 with a Small-Molecule Inhibitor Ameliorates 2, 4-Dinitrochlorobenzene-Induced Skin Inflammation, J. Investig. Dermatol., 141, 1851, 10.1016\u002Fj.jid.2020.12.029",{"doi":3414},"10.1016\u002Fj.jid.2020.12.029",{"id":24,"text":3416,"url":24,"identifiers":3417},"Hipskind, 1994, Ras\u002FMap Kinase-Dependent and-Independent Signaling Pathways Target Distinct Ternary Complex Factors, Genes Dev., 8, 1803, 10.1101\u002Fgad.8.15.1803",{"doi":3418},"10.1101\u002Fgad.8.15.1803",{"id":24,"text":3420,"url":24,"identifiers":3421},"Nakashima, 2022, Innovation in the Treatment of Atopic Dermatitis: Emerging Topical and Oral Janus Kinase Inhibitors, Allergol. Int., 71, 40, 10.1016\u002Fj.alit.2021.10.004",{"doi":3422},"10.1016\u002Fj.alit.2021.10.004",{"id":24,"text":3424,"url":24,"identifiers":3425},"Francomano, F., Caruso, A., Barbarossa, A., Fazio, A., La Torre, C., Ceramella, J., Mallamaci, R., Saturnino, C., Iacopetta, D., and Sinicropi, M.S. (2019). Β-Caryophyllene: A Sesquiterpene with Countless Biological Properties. Appl. Sci., 9.",{"doi":3426},"10.3390\u002Fapp9245420",{"id":24,"text":3428,"url":24,"identifiers":3429},"Shin, 2021, Inhibition of Egr-1-Dependent Mmp1 Transcription by Ethanol Extract of Ageratum Houstonianum in Hacat Keratinocytes, Mol. Biol. Rep., 48, 1, 10.1007\u002Fs11033-020-06091-1",{"doi":3430},"10.1007\u002Fs11033-020-06091-1",{"id":24,"text":3432,"url":24,"identifiers":3433},"Bastaki, 2020, Dietary Administration of Β-Caryophyllene and Its Epoxide to Sprague-Dawley Rats for 90 Days, Food Chem. 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Saikosaponin a and Saikosaponin C Reduce Tnf-Alpha-Induced Tslp Expression through Inhibition of Mapk-Mediated Egr1 Expression in Hacat Keratinocytes. Int. J. Mol. Sci., 23.",{"doi":3446},"10.3390\u002Fijms23094857",{"id":24,"text":3448,"url":24,"identifiers":3449},"Matacchione, 2021, Anti-Sasp and Anti-Inflammatory Activity of Resveratrol, Curcumin and Β-Caryophyllene Association on Human Endothelial and Monocytic Cells, Biogerontology, 22, 297, 10.1007\u002Fs10522-021-09915-0",{"doi":3450},"10.1007\u002Fs10522-021-09915-0",{"id":24,"text":3452,"url":24,"identifiers":3453},"Li, 2020, Β-Caryophyllene Inhibits High Glucose-Induced Oxidative Stress, Inflammation and Extracellular Matrix Accumulation in Mesangial Cells, Int. Immunopharmacol., 84, 106556, 10.1016\u002Fj.intimp.2020.106556",{"doi":3454},"10.1016\u002Fj.intimp.2020.106556",{"id":24,"text":3456,"url":24,"identifiers":3457},"Sousa, 2022, Β-Caryophyllene and Docosahexaenoic Acid, Isolated or Associated, Have Potential Antinociceptive and Anti-Inflammatory Effects in Vitro and in Vivo, Sci. Rep., 12, 19199, 10.1038\u002Fs41598-022-23842-1",{"doi":3458},"10.1038\u002Fs41598-022-23842-1",{"id":24,"text":3460,"url":24,"identifiers":3461},"Gushiken, 2022, Beta-Caryophyllene as an Antioxidant, Anti-Inflammatory and Re-Epithelialization Activities in a Rat Skin Wound Excision Model, Oxid. Med. Cell. Longev., 2022, 9004014, 10.1155\u002F2022\u002F9004014",{"doi":3462},"10.1155\u002F2022\u002F9004014",{"id":24,"text":3464,"url":24,"identifiers":3465},"Yeo, 2022, Transcription Factor Egr1 Regulates the Expression of the Clock Gene Per2 under Il-4 Stimulation in Human Keratinocytes, J. Investig. Dermatol., 142, 2677, 10.1016\u002Fj.jid.2022.03.021",{"doi":3466},"10.1016\u002Fj.jid.2022.03.021",{"id":3468,"createTime":3469,"updateTime":3470,"relativeEntities":3471,"slug":3472,"properties":3473,"entityType":172,"verifyStatus":173,"verifyTime":3469,"verifyNote":174,"languages":3489,"translateLanguages":3490,"viewCount":25,"primaryUrl":3491,"fullTextUrl":24,"authors":3492,"publicationType":290,"publisherRelationship":3578,"citationCount":1965,"citationInfo":3656,"publishDate":24,"publishYear":24,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":3658,"openAccess":24,"references":3659,"isForceReanalyzing":853},"f0fe0e4e-e754-4505-82af-251500a095f7","2024-09-17T21:43:35.562+00:00","2026-09-05T01:31:37.383+00:00",[],"Food-Derived-Bioactives-Can-Protect-the-Anti-Inflammatory-Activity-of-Cortisol-with-Antioxidant-Dependent-and-Independent-Mechanisms",{"mag":3474,"pmc":3476,"openalex":3478,"abstract":3480,"title":3482,"pm":3485,"doi":3487},{"VOID":3475},"2259506270",{"VOID":3477},"4783970",{"VOID":3479},"W2259506270",{"EN":3481},"\u003Cjats:p>In chronic inflammatory diseases the anti-inflammatory effect of glucocorticoids (GCs) is often decreased, leading to GC resistance. Inflammation is related with increased levels of reactive oxygen species (ROS), leading to oxidative stress which is thought to contribute to the development of GC resistance. Plant-derived compounds such as flavonoids are known for their ability to protect against ROS. In this exploratory study we screened a broad range of food-derived bioactives for their antioxidant and anti-inflammatory effects in order to investigate whether their antioxidant effects are associated with the ability to preserve the anti-inflammatory effects of cortisol. The anti-inflammatory potency of the tested compounds was assessed by measuring the oxidative stress–induced GC resistance in human macrophage-like cells. Cells were pre-treated with H2O2 (800 µM) with and without bioactives and then exposed to lipopolysaccharides (LPS) (10 ng\u002FmL) and cortisol (100 nM). The level of inflammation was deducted from the concentration of interleukin-8 (IL-8) in the medium. Intracellular oxidative stress was measured using the fluorescent probe 2′,7′-dichlorofluorescein (DCFH). We found that most of the dietary bioactives display antioxidant and anti-inflammatory action through the protection of the cortisol response. All compounds, except for quercetin, revealing antioxidant activity also protect the cortisol response. This indicates that the antioxidant activity of compounds plays an important role in the protection of the GC response. However, next to the antioxidant activity of the bioactives, other mechanisms also seem to be involved in this protective, anti-inflammatory effect.\u003C\u002Fjats:p>",{"EN":3483,"VI":3484},"Food-Derived Bioactives Can Protect the Anti-Inflammatory Activity of Cortisol with Antioxidant-Dependent and -Independent Mechanisms","Các hoạt chất sinh học từ thực phẩm có thể bảo vệ hoạt tính kháng viêm của cortisol thông qua cơ chế phụ thuộc và không phụ thuộc chất chống oxy hóa",{"VOID":3486},"26891295",{"VOID":3488},"10.3390\u002Fijms17020239",[176],[178],"https:\u002F\u002Fwww.mdpi.com\u002F1422-0067\u002F17\u002F2\u002F239",[3493,3510,3527,3544,3561],{"id":3494,"sortIndex":25,"researcher":24,"roles":3495,"affiliations":3496,"properties":3505,"displayName":3507,"givenName":24,"familyName":24},"efe6225c-fc14-484a-b783-b246af5b3704",[],[3497],{"id":3498,"sortIndex":25,"affiliation":3499,"properties":24},"02e92655-4133-496b-9ac5-9628b9a78dc4",{"id":3498,"createTime":24,"updateTime":24,"relativeEntities":3500,"slug":24,"properties":3501,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":3504,"statistic":24},[],{"title":3502},{"EN":3503},"Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Health Sciences, Maastricht University, Maastricht 3600 MD, The Netherlands",[],{"title":3506,"openalex":3508},{"EN":3507},"Erik J. 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Biochem., 13, 572, 10.1016\u002FS0955-2863(02)00208-5",{"doi":3687},"10.1016\u002FS0955-2863(02)00208-5",{"id":24,"text":3689,"url":24,"identifiers":3690},"Duenas, 2010, Antioxidant evaluation of O-methylated metabolites of catechin, epicatechin and quercetin, J. Pharm. Biomed. Anal., 51, 443, 10.1016\u002Fj.jpba.2009.04.007",{"doi":3691},"10.1016\u002Fj.jpba.2009.04.007",{"id":24,"text":3693,"url":24,"identifiers":3694},"Boots, 2008, Health effects of quercetin: From antioxidant to nutraceutical, Eur. J. Pharmacol., 585, 325, 10.1016\u002Fj.ejphar.2008.03.008",{"doi":3695},"10.1016\u002Fj.ejphar.2008.03.008",{"id":24,"text":3697,"url":24,"identifiers":3698},"Weseler, 2010, Oxidative stress and vascular function: Implications for pharmacologic treatments, Curr. Hypertens. 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Interfaces, 7, 8404, 10.1021\u002Facsami.5b01213",{"doi":4195},"10.1021\u002Facsami.5b01213",{"id":24,"text":4197,"url":24,"identifiers":4198},"Liao, 2018, Self-assembled pH-responsive polymeric micelles for highly efficient, noncytotoxic delivery of doxorubicin chemotherapy to inhibit macrophage activation: In vitro investigation, Biomacromolecules, 19, 2772, 10.1021\u002Facs.biomac.8b00380",{"doi":4199},"10.1021\u002Facs.biomac.8b00380",{"id":4201,"createTime":4202,"updateTime":4203,"relativeEntities":4204,"slug":4205,"properties":4206,"entityType":172,"verifyStatus":173,"verifyTime":4202,"verifyNote":174,"languages":4222,"translateLanguages":4223,"viewCount":25,"primaryUrl":4224,"fullTextUrl":24,"authors":4225,"publicationType":290,"publisherRelationship":4306,"citationCount":4383,"citationInfo":4384,"publishDate":24,"publishYear":24,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":4386,"openAccess":24,"references":4387,"isForceReanalyzing":853},"2422b385-bf68-42b8-8fa0-a113955fe983","2024-09-03T14:09:50.868+00:00","2026-09-04T14:13:13.520+00:00",[],"Amino-Acid-Transporters-Are-a-Vital-Focal-Point-in-the-Control-of-mTORC1-Signaling-and-Cancer",{"mag":4207,"pmc":4209,"openalex":4211,"abstract":4213,"title":4215,"pm":4218,"doi":4220},{"VOID":4208},"3117340121",{"VOID":4210},"7792758",{"VOID":4212},"W3117340121",{"EN":4214},"\u003Cjats:p>The mechanistic target of rapamycin complex 1 (mTORC1) integrates signals from growth factors and nutrients to control biosynthetic processes, including protein, lipid, and nucleic acid synthesis. Dysregulation in the mTORC1 network underlies a wide array of pathological states, including metabolic diseases, neurological disorders, and cancer. Tumor cells are characterized by uncontrolled growth and proliferation due to a reduced dependency on exogenous growth factors. The genetic events underlying this property, such as mutations in the PI3K-Akt and Ras-Erk signaling networks, lead to constitutive activation of mTORC1 in nearly all human cancer lineages. Aberrant activation of mTORC1 has been shown to play a key role for both anabolic tumor growth and resistance to targeted therapeutics. While displaying a growth factor-independent mTORC1 activity and proliferation, tumors cells remain dependent on exogenous nutrients such as amino acids (AAs). AAs are an essential class of nutrients that are obligatory for the survival of any cell. Known as the building blocks of proteins, AAs also act as essential metabolites for numerous biosynthetic processes such as fatty acids, membrane lipids and nucleotides synthesis, as well as for maintaining redox homeostasis. In most tumor types, mTORC1 activity is particularly sensitive to intracellular AA levels. This dependency, therefore, creates a targetable vulnerability point as cancer cells become dependent on AA transporters to sustain their homeostasis. The following review will discuss the role of AA transporters for mTORC1 signaling in cancer cells and their potential as therapeutic drug targets.\u003C\u002Fjats:p>",{"EN":4216,"VI":4217},"Amino Acid Transporters Are a Vital Focal Point in the Control of mTORC1 Signaling and Cancer","Các chất vận chuyển axit amin là tiêu điểm thiết yếu trong kiểm soát truyền tín hiệu mTORC1 và ung thư",{"VOID":4219},"33375025",{"VOID":4221},"10.3390\u002Fijms22010023",[176],[178],"https:\u002F\u002Fwww.mdpi.com\u002F1422-0067\u002F22\u002F1\u002F23",[4226,4245,4264,4281],{"id":4227,"sortIndex":25,"researcher":24,"roles":4228,"affiliations":4229,"properties":4238,"displayName":4242,"givenName":24,"familyName":24},"e217fa22-06c8-4232-a234-016a8dbbe0ee",[],[4230],{"id":4231,"sortIndex":25,"affiliation":4232,"properties":24},"c8cabcef-4357-480a-bd26-49178c02f9d2",{"id":4231,"createTime":24,"updateTime":24,"relativeEntities":4233,"slug":24,"properties":4234,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":4237,"statistic":24},[],{"title":4235},{"EN":4236},"Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA",[],{"orcid":4239,"title":4241,"openalex":4243},{"VOID":4240},"https:\u002F\u002Forcid.org\u002F0000-0003-4913-0327",{"EN":4242},"Yann Cormerais",{"VOID":4244},"A5080972992",{"id":4246,"sortIndex":138,"researcher":24,"roles":4247,"affiliations":4248,"properties":4257,"displayName":4261,"givenName":24,"familyName":24},"af12017d-87a5-455c-a6f4-7813618eef67",[],[4249],{"id":4250,"sortIndex":25,"affiliation":4251,"properties":24},"3429a1f3-5e31-4064-b4d3-470b0e00789a",{"id":4250,"createTime":24,"updateTime":24,"relativeEntities":4252,"slug":24,"properties":4253,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":4256,"statistic":24},[],{"title":4254},{"EN":4255},"Department of Medical Biology, Centre Scientifique de Monaco (CSM), 98000 Monaco, Monaco;",[],{"orcid":4258,"title":4260,"openalex":4262},{"VOID":4259},"https:\u002F\u002Forcid.org\u002F0000-0002-8542-4296",{"EN":4261},"Milica Vučetić",{"VOID":4263},"A5101535084",{"id":4265,"sortIndex":139,"researcher":24,"roles":4266,"affiliations":4267,"properties":4274,"displayName":4278,"givenName":24,"familyName":24},"734e7f9b-6b37-429a-98e7-8b7ce58064c4",[],[4268],{"id":4250,"sortIndex":25,"affiliation":4269,"properties":24},{"id":4250,"createTime":24,"updateTime":24,"relativeEntities":4270,"slug":24,"properties":4271,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":4273,"statistic":24},[],{"title":4272},{"EN":4255},[],{"orcid":4275,"title":4277,"openalex":4279},{"VOID":4276},"https:\u002F\u002Forcid.org\u002F0000-0002-6558-7856",{"EN":4278},"Scott K. 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Lacassagne, Faculté de Médecine (IRCAN), Université Côte d'Azur, 06107 Nice, France",[],{"id":4250,"sortIndex":138,"affiliation":4294,"properties":24},{"id":4250,"createTime":24,"updateTime":24,"relativeEntities":4295,"slug":24,"properties":4296,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":4298,"statistic":24},[],{"title":4297},{"EN":4255},[],{"orcid":4300,"title":4302,"openalex":4304},{"VOID":4301},"https:\u002F\u002Forcid.org\u002F0000-0003-2779-6902",{"EN":4303},"Jacques 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2017, mTOR Signaling in Growth, Metabolism, and Disease, Cell, 169, 361, 10.1016\u002Fj.cell.2017.03.035",{"doi":4391},"10.1016\u002Fj.cell.2017.03.035",{"id":24,"text":4393,"url":24,"identifiers":4394},"Manning, 2017, mTORC1 signaling and the metabolic control of cell growth, Curr. 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The rheological behaviors of the solutions were measured with rotational rheometryunder different conditions, including temperatures, concentration, and molecular weight ofPAN. The solutions exhibited shear-thinning behaviors, similar to that of PAN\u002FDMFsolutions. The viscosities decreased with the increasing of shear rates. However, theviscosity decreased sharply at high shear rates when the concentration was up to 16wt%. Thedependence of the viscosity on temperature was analyzed through the determination of theapparent activation energy. Unusually, the viscosity of solutions of higher concentration islower than that of lower concentration. Similarly, the viscosity of low molecular weightPAN was higher than high molecular weight PAN at high shear rates. The dynamicrheological measurement indicates the loss modulus is much higher than storage modulus.The trend of complex viscosity is similar with the result of static rheological measurement.The interaction between PAN and ionic liquid [BMIM]Cl was discussed.\u003C\u002Fjats:p>",{"EN":4930,"VI":4931},"Rheological Behaviors of Polyacrylonitrile\u002F1-Butyl-3- Methylimidazolium Chloride Concentrated Solutions","Hành vi lưu biến của các dung dịch đậm đặc Polyacrylonitrile\u002F1-Butyl-3- methylimidazolium 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