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Unsystematic findings suggest an influence of comorbidities on the extent of differences in the length of hospital stay (LOS). This systematic review aimed to identify and evaluate all studies reporting LOS in PWD as compared to PwoD in general hospitals.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>A systematic review of observational studies using PubMed and ISI Web of Knowledge. Inclusion criteria comprised original studies written in English or German, assessment of diagnosis of dementia, measurement of LOS, and comparison of people with and without dementia.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Fifty‐two of 60 studies reported a longer hospitalization time for PWD compared to PwoD. The extent of the difference in LOS varied between and within countries as well as by type of primary morbidity (eg, injuries, cardiovascular diseases). The range of the LOS difference for studies without restriction to a primary morbidity was −2 to +22 days after matching or adjustment for a variable number and selection of potentially relevant covariates. For studies with injuries\u002Ffractures\u002Fmedical procedures and infectious\u002Fvascular disease as the primary morbidity, the range was −2.9 to +12.4 and −11.2 to +21.8 days, respectively.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>The majority of studies reported a longer hospitalization of PWD compared to PwoD. Length of hospital stay seems to be influenced by a variety of medical, social, organizational factors, including reasons for hospital admission, whose role should be explored in detail in further research.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":142},"Length of hospital stay and dementia: A systematic review of observational studies",{"VOID":144},"30260050",{"VOID":146},"10.1002\u002Fgps.4993","PUBLICATION","VERIFIED","Auto 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determine the frequency, risk factors, course and outcomes of subsyndromal delirium (SSD) in older people by systematically reviewing evidence on these topics.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>Subsyndromal delirium was defined as the presence of one or more symptoms of delirium, not meeting criteria for delirium and not progressing to delirium. MEDLINE, EMBASE, PsycINFO and the Web of Science were searched for potentially relevant articles published from 1996 to June 2011. The bibliographies of relevant articles were searched for additional references. Twelve studies met the inclusion criteria. The validity of included studies was assessed according to Evidence‐Based Medicine criteria. Information about the study population and methods, age, gender, proportion with dementia, diagnostic criteria, period and frequency of observation, and the topics above was systematically abstracted, tabulated and synthesized using standard meta‐analysis techniques.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>The combined prevalence of SSD was 23% (95% CI, 9–42%); the combined incidence was 13% (95% CI, 6–23%). Risk factors were similar to those for delirium. Episodes lasted up to 133 days and were often recurrent. Outcomes were poor and often intermediate between those of older people with or without delirium. Of note, there was significant unexplained heterogeneity in the results of studies of prevalence, incidence and some risk factors.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>SSD in older people may be a frequent and clinically important condition that falls on a continuum between no symptoms and full delirium. Because of significant unexplained heterogeneity in the results of studies of SSD, however, the results of this review must be interpreted cautiously. Further research is necessary. Copyright © 2012 John Wiley & Sons, Ltd.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":606},"Subsyndromal delirium in older people: a systematic review of frequency, risk factors, course and outcomes",{"VOID":608},"23124811",{"VOID":610},"10.1002\u002Fgps.3891",[151],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fgps.3891",[614,633,661,699],{"id":615,"sortIndex":156,"researcher":24,"roles":616,"affiliations":617,"properties":628},"293a3def-c270-41f6-85a9-2a039ba92091",[],[618],{"id":619,"sortIndex":25,"affiliation":620,"properties":24},"b4c3b514-23c1-42fa-8842-093d7a3d3cee",{"id":621,"createTime":622,"updateTime":622,"relativeEntities":623,"slug":624,"properties":625,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"1f97063f-1214-4dda-b00d-8d26d14519f2","2024-10-10T23:29:24.285+00:00",[],"St-Mary-s-Research-Center-St-Mary-s-Hospital-Center-Montreal-QC-Canada",{"title":626},{"EN":627},"St. Mary's Research Center, St. Mary's Hospital Center, Montreal, QC, Canada",{"openalex":629,"title":631},{"VOID":630},"A5050912057",{"EN":632},"Éric Belzile",{"id":634,"sortIndex":179,"researcher":24,"roles":635,"affiliations":636,"properties":654},"eab9dd60-4a08-4c9f-b12b-cf074312b3ee",[],[637,643],{"id":638,"sortIndex":179,"affiliation":639,"properties":24},"0364de31-eddc-4f88-94a6-57428e178ba5",{"id":621,"createTime":622,"updateTime":622,"relativeEntities":640,"slug":624,"properties":641,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":642},{"EN":627},{"id":644,"sortIndex":25,"affiliation":645,"properties":24},"a4ee46fd-7af8-4594-863f-03822778de58",{"id":646,"createTime":647,"updateTime":648,"relativeEntities":649,"slug":650,"properties":651,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"a1765083-1a03-44e0-8dab-c8c092997e3d","2023-12-06T13:53:22.175+00:00","2024-10-16T19:42:03.674+00:00",[],"Department-of-Epidemiology-Biostatistics-and-Occupational-Health-McGill-University-Montreal-QC-Canada",{"title":652},{"VI":653},"Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada",{"openalex":655,"orcid":657,"title":659},{"VOID":656},"A5026106434",{"VOID":658},"https:\u002F\u002Forcid.org\u002F0000-0003-4838-8297",{"EN":660},"Antonio Ciampi",{"id":662,"sortIndex":25,"researcher":24,"roles":663,"affiliations":664,"properties":692},"a4d5500b-2313-4632-9d32-8549f84b1916",[],[665,671,681],{"id":666,"sortIndex":156,"affiliation":667,"properties":24},"5dc3f51f-2e34-46ca-b4b6-c540799004af",{"id":621,"createTime":622,"updateTime":622,"relativeEntities":668,"slug":624,"properties":669,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":670},{"EN":627},{"id":672,"sortIndex":179,"affiliation":673,"properties":24},"80903a47-b561-4bc4-8df0-e7016cc71ebb",{"id":674,"createTime":675,"updateTime":675,"relativeEntities":676,"slug":677,"properties":678,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"720ce99d-d133-4368-ac93-61ca95c199e7","2024-10-10T23:29:24.281+00:00",[],"Department-of-Psychiatry-St-Mary-s-Hospital-Center-Montreal-QC-Canada",{"title":679},{"EN":680},"Department of Psychiatry, St. Mary's Hospital Center, Montreal, QC, Canada",{"id":682,"sortIndex":25,"affiliation":683,"properties":24},"a7b02f4b-de8d-43b3-8d04-04bd2774aa89",{"id":684,"createTime":685,"updateTime":686,"relativeEntities":687,"slug":688,"properties":689,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"47d2ceb2-e54b-4489-80d1-8b9ea6e2200b","2024-01-04T14:17:44.534+00:00","2024-12-30T21:31:37.027+00:00",[],"Department-of-Psychiatry-McGill-University-Montreal-QC-Canada",{"title":690},{"VI":691},"Department of Psychiatry, McGill University, Montreal, QC, Canada",{"openalex":693,"orcid":695,"title":697},{"VOID":694},"A5091576764",{"VOID":696},"https:\u002F\u002Forcid.org\u002F0000-0002-4645-8856",{"EN":698},"Martín G. 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The implementation of the original NICE (\u003Cjats:ext-link xmlns:xlink=\"http:\u002F\u002Fwww.w3.org\u002F1999\u002Fxlink\" xlink:href=\"#bib6\">2001\u003C\u002Fjats:ext-link>) guidance that made these drugs available in the UK was not examined in this review process, and was the objective of this study.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Method\u003C\u002Fjats:title>\u003Cjats:p>Ten hospitals in and around Manchester participated in the audit. Case records of all patients who were started on ChEIs between January 2002 and the date of the audit (November 2003 to December 2004) were examined to assess adherence to the NICE (\u003Cjats:ext-link xmlns:xlink=\"http:\u002F\u002Fwww.w3.org\u002F1999\u002Fxlink\" xlink:href=\"#bib6\">2001\u003C\u002Fjats:ext-link>) guidance. Information about available resources was gathered from lead clinicians of each hospital.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>A total of 1092 case records were examined. The treatment of AD with ChEIs varied considerably with regard to pre‐treatment investigations, waiting period for treatment, scales used to assess efficacy, adherence to the NICE (\u003Cjats:ext-link xmlns:xlink=\"http:\u002F\u002Fwww.w3.org\u002F1999\u002Fxlink\" xlink:href=\"#bib6\">2001\u003C\u002Fjats:ext-link>) guidance, and available resources. The actual number of patients with mild to moderate AD receiving ChEIs was much lower than that expected from known prevalence rates. Non‐uniformity of clinical practice and missing data were the main limitations of the audit.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusion\u003C\u002Fjats:title>\u003Cjats:p>There is a need to harmonise the use and monitoring of ChEIs for AD in the NHS so that the data from routine clinical practice could feed into future clinical and cost‐effectiveness analyses. Copyright © 2006 John Wiley & Sons, Ltd.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":882},"Cholinesterase inhibitors for Alzheimer's disease: variations in clinical practice in the north‐west of England",{"VOID":884},"16927408",{"VOID":886},"10.1002\u002Fgps.1591",[151],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fgps.1591",[890,911,926,943],{"id":891,"sortIndex":255,"researcher":24,"roles":892,"affiliations":893,"properties":904},"c8c94cf6-201d-4f78-bec0-8e9874308082",[],[894],{"id":895,"sortIndex":25,"affiliation":896,"properties":24},"e554a8f3-ce3b-48d0-bfaa-b66973b63004",{"id":897,"createTime":898,"updateTime":898,"relativeEntities":899,"slug":900,"properties":901,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"cce49ffa-5368-4fbf-b963-ca024bda646a","2024-10-07T23:28:19.794+00:00",[],"Department-of-Psychiatary-University-of-Manchester-Manchester-UK",{"title":902},{"EN":903},"Department of Psychiatary, University of Manchester, Manchester, UK",{"openalex":905,"orcid":907,"title":909},{"VOID":906},"A5027171288",{"VOID":908},"https:\u002F\u002Forcid.org\u002F0000-0002-9837-0645",{"EN":910},"Alistair Burns",{"id":912,"sortIndex":25,"researcher":24,"roles":913,"affiliations":914,"properties":921},"233a3c77-e9a5-4126-b12a-8b31a8207ea3",[],[915],{"id":916,"sortIndex":25,"affiliation":917,"properties":24},"e54871b8-9294-4337-829b-adb6fedaeebc",{"id":897,"createTime":898,"updateTime":898,"relativeEntities":918,"slug":900,"properties":919,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":920},{"EN":903},{"openalex":922,"title":924},{"VOID":923},"A5042000404",{"EN":925},"Nitin 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2001, Guidance on the use of donepezil, rivastigmine and galantamine for the treatment of Alzheimer's disease. Technology Appraisal Guidance No. 19",{},{"id":24,"text":1027,"url":24,"identifiers":1028},"NICE, 2005, Appraisal Consultation Document: Alzheimer's disease—donepezil, rivastigmine, galantamine and memantine (review)",{},{"id":24,"text":1030,"url":24,"identifiers":1031},"NICE, 2005, Press Statement. Update on the NICE appraisal of Alzheimer drugs",{},{"id":24,"text":1033,"url":24,"identifiers":1034},"NICE, 2006, Appraisal Consultation Document: donepezil, galantamine, rivastigmine (review) and memantine for the treatment of Alzheimer's disease",{},{"id":24,"text":1036,"url":24,"identifiers":1037},"10.3310\u002Fhta9200",{"doi":1036},{"id":24,"text":1039,"url":24,"identifiers":1040},"10.1002\u002Fgps.1188",{"doi":1039},{"id":1042,"createTime":1043,"updateTime":1043,"relativeEntities":1044,"slug":1045,"properties":1046,"entityType":147,"verifyStatus":148,"verifyTime":1043,"verifyNote":149,"syncStatus":23,"languages":1060,"translateLanguages":24,"viewCount":25,"primaryUrl":1061,"fullTextUrl":24,"authors":1062,"publicationType":271,"publisherRelationship":1107,"citationCount":1146,"citationInfo":1147,"publishDate":1149,"publishYear":1150,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1151,"isForceReanalyzing":591},"d33edb7a-4818-4090-b01c-3d5284e5d7c8","2024-10-12T23:05:17.015+00:00",[],"Cognitive-and-psychiatric-predictors-of-medical-treatment-adherence-among-older-adults-in-primary-care-clinics",{"mag":1047,"keywords":1049,"openalex":1050,"abstract":1052,"title":1054,"pm":1056,"doi":1058},{"VOID":1048},"2060709783",{},{"VOID":1051},"W2060709783",{"EN":1053},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Objectives\u003C\u002Fjats:title>\u003Cjats:p>Medical treatment non‐adherence among older adults is common and represents a significant public health care concern. Treatment non‐adherence has been associated with a number of factors in older adults; however few studies have delineated the role of cognition and psychiatric status.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Participants\u003C\u002Fjats:title>\u003Cjats:p>Data were collected from 212 ethnically diverse older primary care patients as part of a larger study.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Measurements\u003C\u002Fjats:title>\u003Cjats:p>Cognitive status was evaluated with the Mattis Dementia Rating scale (DRS). Psychiatric status was evaluated using the Geriatric Depression Scale (GDS) and the Beck Anxiety Inventory (BAI). Treatment adherence was assessed by the total number of missed healthcare appointments and by physician and patient ratings. Physician ratings of patients' understanding of medical instructions were also obtained.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Design\u003C\u002Fjats:title>\u003Cjats:p>A series of multiple regression analyses were conducted to determine cognitive and psychiatric predictors for each measure of treatment adherence.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>GDS and DRS memory scores were both independent predictors of the total number of missed medical appointments, \u003Cjats:italic>F\u003C\u002Fjats:italic>(7,55) = 2.34, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.038. GDS score was also shown to be a significant predictor of physician ratings of patients' understanding of medical instructions, \u003Cjats:italic>F\u003C\u002Fjats:italic>(7,33) = 0.89, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.031. Neither cognitive performance nor psychiatric status was associated with patient or physician ratings of treatment adherence.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>Measures of cognitive functioning and depression severity were supported as predictors of objective measures of treatment adherence but they were not associated with physician or patient ratings of adherence. Patient depression may influence physician ratings of patients' comprehension of medical instructions. Copyright © 2006 John Wiley & Sons, Ltd.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":1055},"Cognitive and psychiatric predictors of medical treatment adherence among older adults in primary care clinics",{"VOID":1057},"17006873",{"VOID":1059},"10.1002\u002Fgps.1653",[151],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fgps.1653",[1063,1088],{"id":1064,"sortIndex":179,"researcher":24,"roles":1065,"affiliations":1066,"properties":1081},"9fd39102-259d-4325-9ed5-461ad8396388",[],[1067],{"id":1068,"sortIndex":25,"affiliation":1069,"properties":1078},"878b5bd7-0b0f-4657-8892-87fba05fbec9",{"id":1070,"createTime":1071,"updateTime":1072,"relativeEntities":1073,"slug":1074,"properties":1075,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"3f3560ec-8aee-43d0-8964-3846915df893","2023-11-30T11:11:22.996+00:00","2024-12-06T04:45:40.878+00:00",[],"Department-of-Psychiatry-University-of-California-San-Francisco-CA-United-States",{"title":1076},{"VI":1077},"Department of Psychiatry, University of California, San Francisco, CA, United States",{"title":1079},{"EN":1080},"Department of Psychiatry, University of California, San Francisco, CA, USA.",{"openalex":1082,"orcid":1084,"title":1086},{"VOID":1083},"A5025522473",{"VOID":1085},"https:\u002F\u002Forcid.org\u002F0000-0001-5971-6319",{"EN":1087},"Patricia A. 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A, 1988, Beck Anxiety Inventory",{},{"id":24,"text":1168,"url":24,"identifiers":1169},"10.1001\u002Farchinte.160.14.2129",{"doi":1168},{"id":24,"text":1171,"url":24,"identifiers":1172},"10.1001\u002Fjama.288.4.455",{"doi":1171},{"id":24,"text":1174,"url":24,"identifiers":1175},"Bosley CM, 1995, The psychological factors associated with poor compliance with treatment in asthma, Eur Respir J, 8, 899, 10.1183\u002F09031936.95.08060899",{"doi":1176},"10.1183\u002F09031936.95.08060899",{"id":24,"text":1178,"url":24,"identifiers":1179},"Brink TL, 1982, Screening test for geriatric depression, Clin Gerontologist, 1, 37, 10.1300\u002FJ018v01n01_06",{"doi":1180},"10.1300\u002FJ018v01n01_06",{"id":24,"text":1182,"url":24,"identifiers":1183},"10.1093\u002Fgerona\u002F58.6.M548",{"doi":1182},{"id":24,"text":1185,"url":24,"identifiers":1186},"10.1016\u002FS0197-2456(00)00081-7",{"doi":1185},{"id":24,"text":1188,"url":24,"identifiers":1189},"10.1097\u002F00005082-200407000-00006",{"doi":1188},{"id":24,"text":1191,"url":24,"identifiers":1192},"10.1097\u002F01.PSY.0000040951.22044.59",{"doi":1191},{"id":24,"text":1194,"url":24,"identifiers":1195},"10.1034\u002Fj.1600-0404.107.s179.4.x",{"doi":1194},{"id":24,"text":1197,"url":24,"identifiers":1198},"10.1017\u002FS1041610204000067",{"doi":1197},{"id":24,"text":1200,"url":24,"identifiers":1201},"10.1345\u002Faph.10295",{"doi":1200},{"id":24,"text":1203,"url":24,"identifiers":1204},"10.1111\u002Fj.1532-5415.1988.tb04395.x",{"doi":1203},{"id":24,"text":1206,"url":24,"identifiers":1207},"10.2105\u002FAJPH.83.5.711",{"doi":1206},{"id":24,"text":1209,"url":24,"identifiers":1210},"10.1016\u002FS1474-5151(03)00058-6",{"doi":1209},{"id":24,"text":1212,"url":24,"identifiers":1213},"10.1093\u002Fajhp\u002F61.19.2043",{"doi":1212},{"id":24,"text":1215,"url":24,"identifiers":1216},"10.2165\u002F00002512-200421120-00004",{"doi":1215},{"id":24,"text":1218,"url":24,"identifiers":1219},"10.1097\u002F00006842-199907000-00023",{"doi":1218},{"id":24,"text":1221,"url":24,"identifiers":1222},"10.1093\u002Fgeront\u002F38.4.412",{"doi":1221},{"id":24,"text":1224,"url":24,"identifiers":1225},"10.1016\u002FS0887-6185(96)00033-3",{"doi":1224},{"id":24,"text":1227,"url":24,"identifiers":1228},"10.1016\u002Fj.ypmed.2004.04.041",{"doi":1227},{"id":24,"text":1230,"url":24,"identifiers":1231},"10.1093\u002Fgerona\u002F59.9.M958",{"doi":1230},{"id":24,"text":1233,"url":24,"identifiers":1234},"10.1001\u002Farchinte.159.19.2312",{"doi":1233},{"id":24,"text":1236,"url":24,"identifiers":1237},"Lewis A, 1997, Noncompliance: a $100 billion problem, Remington Report, 5, 5",{},{"id":24,"text":1239,"url":24,"identifiers":1240},"10.1001\u002Farchneur.60.10.1385",{"doi":1239},{"id":24,"text":1242,"url":24,"identifiers":1243},"10.1001\u002Fjama.288.12.1475",{"doi":1242},{"id":24,"text":1245,"url":24,"identifiers":1246},"10.1002\u002Fgps.688",{"doi":1245},{"id":24,"text":1248,"url":24,"identifiers":1249},"Mattis S, 2004, Dementia Rating Scale‐2: Professional Manual",{},{"id":24,"text":1251,"url":24,"identifiers":1252},"10.1046\u002Fj.1532-5415.2001.49147.x",{"doi":1251},{"id":24,"text":1254,"url":24,"identifiers":1255},"10.1258\u002F0956462021925117",{"doi":1254},{"id":24,"text":1257,"url":24,"identifiers":1258},"10.1007\u002Fs002280100347",{"doi":1257},{"id":24,"text":1260,"url":24,"identifiers":1261},"10.1161\u002F01.STR.30.10.2167",{"doi":1260},{"id":24,"text":1263,"url":24,"identifiers":1264},"10.1016\u002FS0002-9343(97)89521-6",{"doi":1263},{"id":24,"text":1266,"url":24,"identifiers":1267},"10.3928\u002F0098-9134-20040701-08",{"doi":1266},{"id":24,"text":1269,"url":24,"identifiers":1270},"Smith CM, 1994, Factors associated with appointment keeping in a family practice residency clinic, J Fam Pract, 38, 25",{},{"id":24,"text":1272,"url":24,"identifiers":1273},"10.1016\u002F0022-3956(82)90033-4",{"doi":1272},{"id":1275,"createTime":1276,"updateTime":1276,"relativeEntities":1277,"slug":1278,"properties":1279,"entityType":147,"verifyStatus":148,"verifyTime":1276,"verifyNote":149,"syncStatus":23,"languages":1293,"translateLanguages":24,"viewCount":25,"primaryUrl":1294,"fullTextUrl":24,"authors":1295,"publicationType":271,"publisherRelationship":1337,"citationCount":1377,"citationInfo":1378,"publishDate":1380,"publishYear":1381,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1382,"isForceReanalyzing":591},"68eb54c6-b3d4-45f7-a1fe-807a54ac7fac","2024-09-20T22:37:40.737+00:00",[],"Association-of-life-events-and-psychosocial-factors-with-early-but-not-late-onset-depression-in-the-elderly-implications-for-possible-differences-in-aetiology",{"mag":1280,"keywords":1282,"openalex":1283,"abstract":1285,"title":1287,"pm":1289,"doi":1291},{"VOID":1281},"2075928275",{},{"VOID":1284},"W2075928275",{"EN":1286},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Background\u003C\u002Fjats:title>\u003Cjats:p>Depression occurring for the first time in later life (after age 60, late onset depression (LOD)) may have a different, more organic, aetiology from early onset depression (EOD). We investigated the possible role of life events, the presence of a confidante and personality factors in the aetiology of depression in the elderly, testing the hypothesis that these factors would be associated with EOD but not LOD.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>Subjects consisted of 66 elderly patients (aged over 60) with DSM‐IV Major depression (30 EOD, 33 LOD; groups matched for age) and 38 age and sex matched controls. Life events in the 12 months prior to onset of depression (or prior to interview for controls) were recorded using a previously validated 12‐item scale. Personality was assessed using the Eysenck Personality Questionnaire (EPQ).\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Subjects with EOD reported having a close confidente significantly less frequently (52%) than controls (82%, \u003Cjats:italic>p\u003C\u002Fjats:italic> < 0.05) or LOD (80%, \u003Cjats:italic>p\u003C\u002Fjats:italic> < 0.05). Bereavement life events occurred significantly more frequently in EOD (52%) than LOD (16%, \u003Cjats:italic>p\u003C\u002Fjats:italic> < 0.01) and were also more frequent in controls (42%) than LOD (\u003Cjats:italic>p\u003C\u002Fjats:italic> < 0.05). Higher EPQ ‘extraversion’ and ‘neuroticism’ were found in both EOD and LOD compared to controls, with no differences between EOD and LOD.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>LOD was associated with fewer bereavement life events and more frequent presence of a confidente than EOD. This supports a greater role for psychosocial factors in the aetiology of EOD and different, probably neurobiological, factors in LOD. Personality attributes may have a greater relevance for both EOD and LOD than previously recognized. Copyright © 2003 John Wiley & Sons, Ltd.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":1288},"Association of life events and psychosocial factors with early but not late onset depression in the elderly: implications for possible differences in aetiology",{"VOID":1290},"12789666",{"VOID":1292},"10.1002\u002Fgps.856",[151],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fgps.856",[1296,1318],{"id":1297,"sortIndex":179,"researcher":24,"roles":1298,"affiliations":1299,"properties":1311},"cb191afd-e828-4115-a898-37acc12ab68e",[],[1300],{"id":1301,"sortIndex":25,"affiliation":1302,"properties":24},"0e733a62-724a-4136-95fe-e3f0c67077ff",{"id":1303,"createTime":1304,"updateTime":1305,"relativeEntities":1306,"slug":1307,"properties":1308,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"9fe78b30-f0fe-4a42-b0a6-1d3baf760033","2024-02-13T11:16:20.706+00:00","2024-09-20T22:37:40.762+00:00",[],"Wolfson-Research-Centre-Institute-for-Ageing-and-Health-Newcastle-General-Hospital-Westgate-Road-Newcastle-upon-Tyne-NE4-6BE-UK",{"title":1309},{"VI":1310},"Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK",{"openalex":1312,"orcid":1314,"title":1316},{"VOID":1313},"A5014262891",{"VOID":1315},"https:\u002F\u002Forcid.org\u002F0000-0002-0837-5080",{"EN":1317},"John T. OʼBrien",{"id":1319,"sortIndex":25,"researcher":24,"roles":1320,"affiliations":1321,"properties":1332},"185b8002-b2f3-472a-9a9b-6a13ab293ff2",[],[1322],{"id":1323,"sortIndex":25,"affiliation":1324,"properties":24},"ec051a05-4e34-4373-a46d-b2069806409f",{"id":1325,"createTime":1326,"updateTime":1326,"relativeEntities":1327,"slug":1328,"properties":1329,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"b5d455b5-583c-4ee4-8b7f-528a3f571a13","2024-09-20T22:37:40.751+00:00",[],"Department-of-Psychiatry-University-of-Newcastle-upon-Tyne-Newcastle-General-Hospital-Newcastle-upon-Tyne-UK",{"title":1330},{"EN":1331},"Department of Psychiatry, University of Newcastle upon Tyne, Newcastle General Hospital, Newcastle upon Tyne, UK",{"openalex":1333,"title":1335},{"VOID":1334},"A5027487868",{"EN":1336},"Janet Grace",{"url":24,"publisher":1338,"properties":1370},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1339,"slug":10,"properties":1340,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1346,"manageAffiliations":1347,"indexDatabases":1348,"url":123,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1341,"issn":1342,"introduce":1343,"eissn":1344,"title":1345},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1349,1356,1363],{"id":67,"indexDatabase":1350,"url":80,"indexYears":81,"academicFieldIds":1355,"indexDatabaseRanking":85},{"id":69,"createTime":70,"updateTime":71,"relativeEntities":1351,"label":1352,"description":1353,"key":77,"publicationTags":1354,"standard":24},[],{"EN":74,"VI":74},{"EN":74,"VI":76},[79],[83,84],{"id":87,"indexDatabase":1357,"url":102,"indexYears":24,"academicFieldIds":1362,"indexDatabaseRanking":24},{"id":89,"createTime":90,"updateTime":91,"relativeEntities":1358,"label":1359,"description":1360,"key":98,"publicationTags":1361,"standard":24},[],{"EN":94,"VI":94},{"VI":96,"EN":97},[100,101],[104,105],{"id":107,"indexDatabase":1364,"url":102,"indexYears":24,"academicFieldIds":1369,"indexDatabaseRanking":24},{"id":109,"createTime":110,"updateTime":111,"relativeEntities":1365,"label":1366,"description":1367,"key":118,"publicationTags":1368,"standard":24},[],{"EN":114,"VI":114},{"VI":116,"EN":117},[120,101],[122,105],{"volume":1371,"pages":1373,"issue":1375},{"VOID":1372},"18",{"VOID":1374},"473-478",{"VOID":1376},"6",41,{"total":1377,"publishYear":24,"statisticByYear":1379},{"2012":255,"2013":231,"2014":255,"2015":156,"2016":231,"2017":179,"2018":179,"2019":179,"2020":179,"2023":179,"2024":156},"2003-06-01",2003,[1383,1386,1389,1392,1395,1398,1401,1404,1407,1410,1414,1417,1420,1423,1425,1428,1431,1434,1437,1440,1443,1446,1449,1452,1455,1458,1461,1464,1467,1470,1473],{"id":24,"text":1384,"url":24,"identifiers":1385},"10.1111\u002Fj.1532-5415.1994.tb06532.x",{"doi":1384},{"id":24,"text":1387,"url":24,"identifiers":1388},"10.1177\u002F070674379604100406",{"doi":1387},{"id":24,"text":1390,"url":24,"identifiers":1391},"10.1001\u002Farchpsyc.1997.01830220033006",{"doi":1390},{"id":24,"text":1393,"url":24,"identifiers":1394},"10.1192\u002Fbjp.180.2.157",{"doi":1393},{"id":24,"text":1396,"url":24,"identifiers":1397},"10.1176\u002Fps.50.3.376",{"doi":1396},{"id":24,"text":1399,"url":24,"identifiers":1400},"10.1016\u002F0165-0327(91)90026-O",{"doi":1399},{"id":24,"text":1402,"url":24,"identifiers":1403},"Brown GW, 1978, Social Origins of Depression",{},{"id":24,"text":1405,"url":24,"identifiers":1406},"10.1192\u002Fbjp.147.6.641",{"doi":1405},{"id":24,"text":1408,"url":24,"identifiers":1409},"10.1016\u002FS0165-0327(97)00152-3",{"doi":1408},{"id":24,"text":1411,"url":24,"identifiers":1412},"Cutrona CE, 1986, Behavioral manifestations of social support: a microanalytic investigation, J Personality Soc Psychol, 51, 201, 10.1037\u002F0022-3514.51.1.201",{"doi":1413},"10.1037\u002F0022-3514.51.1.201",{"id":24,"text":1415,"url":24,"identifiers":1416},"10.1016\u002F0165-0327(95)00062-3",{"doi":1415},{"id":24,"text":1418,"url":24,"identifiers":1419},"Eysenck HJ, 1964, The manuel of the Eysenck Personality Inventory",{},{"id":24,"text":1421,"url":24,"identifiers":1422},"10.2466\u002Fpr0.1976.39.3.1011",{"doi":1421},{"id":24,"text":1018,"url":24,"identifiers":1424},{"doi":1018},{"id":24,"text":1426,"url":24,"identifiers":1427},"10.1161\u002F01.STR.29.3.613",{"doi":1426},{"id":24,"text":1429,"url":24,"identifiers":1430},"10.1016\u002FS0006-3223(96)00363-0",{"doi":1429},{"id":24,"text":1432,"url":24,"identifiers":1433},"10.1016\u002F0022-3999(67)90010-4",{"doi":1432},{"id":24,"text":1435,"url":24,"identifiers":1436},"Kraepelin E, 1921, Manic‐Depressive Insanty and Paranoia",{},{"id":24,"text":1438,"url":24,"identifiers":1439},"10.1177\u002F089198879400700403",{"doi":1438},{"id":24,"text":1441,"url":24,"identifiers":1442},"10.1192\u002Fbjp.134.4.382",{"doi":1441},{"id":24,"text":1444,"url":24,"identifiers":1445},"10.1192\u002Fbjp.141.2.135",{"doi":1444},{"id":24,"text":1447,"url":24,"identifiers":1448},"10.1136\u002Fbmj.317.7164.982",{"doi":1447},{"id":24,"text":1450,"url":24,"identifiers":1451},"10.1192\u002Fbjp.168.4.477",{"doi":1450},{"id":24,"text":1453,"url":24,"identifiers":1454},"10.1001\u002Farchpsyc.1969.01740240113014",{"doi":1453},{"id":24,"text":1456,"url":24,"identifiers":1457},"10.1192\u002Fbjp.121.4.393",{"doi":1456},{"id":24,"text":1459,"url":24,"identifiers":1460},"10.1192\u002Fbjp.101.423.281",{"doi":1459},{"id":24,"text":1462,"url":24,"identifiers":1463},"10.1192\u002Fbjp.149.6.698",{"doi":1462},{"id":24,"text":1465,"url":24,"identifiers":1466},"10.1016\u002FS0033-3182(97)71441-5",{"doi":1465},{"id":24,"text":1468,"url":24,"identifiers":1469},"10.1017\u002FS003329179800693X",{"doi":1468},{"id":24,"text":1471,"url":24,"identifiers":1472},"10.1017\u002FS0033291799001026",{"doi":1471},{"id":24,"text":1474,"url":24,"identifiers":1475},"10.1007\u002Fs001270050220",{"doi":1474},{"id":1477,"createTime":1478,"updateTime":1479,"relativeEntities":1480,"slug":1481,"properties":1482,"entityType":147,"verifyStatus":148,"verifyTime":1500,"verifyNote":149,"syncStatus":23,"languages":1501,"translateLanguages":24,"viewCount":25,"primaryUrl":1502,"fullTextUrl":24,"authors":1503,"publicationType":271,"publisherRelationship":1692,"citationCount":1731,"citationInfo":1732,"publishDate":1735,"publishYear":1736,"citationAnalyzeStatus":1737,"lastCitationAnalyze":1738,"indexDatabases":24,"openAccess":24,"references":1739,"isForceReanalyzing":591},"e990a64b-2bd9-4170-8e00-ab386db95623","2025-02-24T15:29:37.455+00:00","2026-06-17T21:34:11.534+00:00",[],"Augmenting-antidepressant-medication-with-modular-CBT-for-geriatric-generalized-anxiety-disorder-a-pilot-study",{"mag":1483,"keywords":1485,"gsPaper":1486,"pmc":1488,"openalex":1490,"abstract":1492,"title":1494,"pm":1496,"doi":1498},{"VOID":1484},"2084106958",{},{"VOID":1487},"[\"100000802148048682\"]",{"VOID":1489},"4070295",{"VOID":1491},"W2084106958",{"EN":1493},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Objective\u003C\u002Fjats:title>\u003Cjats:p>Generalized anxiety disorder (GAD) is a prevalent psychiatric condition in older adults with deleterious effects on health and cognition. Although selective serotonin reuptake inhibitor (SSRI) medications have some efficacy as acute treatments for geriatric GAD, incomplete response is the most common outcome of monotherapy. We therefore developed a novel sequential treatment strategy, using personalized, modular cognitive‐behavioral therapy (mCBT) to augment SSRI medication.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Method\u003C\u002Fjats:title>\u003Cjats:p>In an open label pilot study (\u003Cjats:italic>N \u003C\u002Fjats:italic>= 10), subjects received a sequenced trial of 12 weeks of escitalopram followed by 16 weeks of escitalopram augmented with mCBT. We also examined the maintenance effects of mCBT over a 28‐week follow‐up period following drug discontinuation and termination of psychotherapy.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Results suggest that (1) adding mCBT to escitalopram significantly reduced anxiety symptoms and pathological worry, resulting in full remission for most patients and (2) some patients maintained response after all treatments were withdrawn.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusion\u003C\u002Fjats:title>\u003Cjats:p>Findings suggest that mCBT may be an effective augmentation strategy when added to SSRI medication and provide limited support for the long‐term benefit of mCBT after discontinuation of pharmacotherapy. Copyright © 2010 John Wiley & Sons, Ltd.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":1495},"Augmenting antidepressant medication with modular CBT for geriatric generalized anxiety disorder: a pilot study",{"VOID":1497},"20872925",{"VOID":1499},"10.1002\u002Fgps.2619","2025-02-24T15:29:37.454+00:00",[151],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fgps.2619",[1504,1538,1557,1580,1607,1630,1652,1667],{"id":1505,"sortIndex":54,"researcher":24,"roles":1506,"affiliations":1507,"properties":1533},"27ba147a-61b1-4440-ac90-5fdf11b15a91",[],[1508,1519],{"id":1509,"sortIndex":25,"affiliation":1510,"properties":24},"57cc1b67-a622-4c4e-bfc9-8756ef5aecb7",{"id":1511,"createTime":1512,"updateTime":1513,"relativeEntities":1514,"slug":1515,"properties":1516,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"874610ed-2beb-408a-9d15-b916cea56172","2024-04-13T08:38:07.792+00:00","2025-02-24T15:29:37.463+00:00",[],"Department-of-Psychiatry-University-of-California-San-Diego-La-Jolla-California-USA",{"title":1517},{"EN":1518},"Department of Psychiatry, University of California San Diego, La Jolla, California, USA",{"id":1520,"sortIndex":179,"affiliation":1521,"properties":1530},"7754e260-0ecb-4fa8-b6d4-cae06312db15",{"id":1522,"createTime":1523,"updateTime":1524,"relativeEntities":1525,"slug":1526,"properties":1527,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"3959e85f-2903-4b17-83a0-e1d9fc1d2744","2024-09-28T12:05:27.213+00:00","2025-02-24T15:29:37.464+00:00",[],"VA-San-Diego-Healthcare-System-San-Diego-California-United-States",{"title":1528},{"EN":1529},"VA San Diego Healthcare System, San Diego, California, United States",{"title":1531},{"EN":1532},"VA San Diego Healthcare System  San Diego California USA",{"openalex":1534,"title":1536},{"VOID":1535},"A5110048901",{"EN":1537},"Sidney Zisook",{"id":1539,"sortIndex":179,"researcher":24,"roles":1540,"affiliations":1541,"properties":1552},"6a19223f-b098-4265-ba75-65e810f0980d",[],[1542],{"id":1543,"sortIndex":25,"affiliation":1544,"properties":24},"c211e5f8-8acb-4bb6-943c-3194e58ff2a1",{"id":1545,"createTime":1546,"updateTime":1546,"relativeEntities":1547,"slug":1548,"properties":1549,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"3e818563-d411-4646-b933-f9be34f48b4f","2025-02-24T15:29:37.470+00:00",[],"Department-of-Psychology-Alliant-International-University-San-Diego-California-USA",{"title":1550},{"EN":1551},"Department of Psychology, Alliant International University, San Diego, California, USA",{"openalex":1553,"title":1555},{"VOID":1554},"A5009281825",{"EN":1556},"Jill A. 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dysfunction is prevalent in older adults with bipolar disorder (BD). High white matter hyperintensity (WMH) burden, a marker of white matter disease, detected on T2\u002Ffluid‐attenuated inversion recovery brain magnetic resonance imaging (MRI) has been consistently reported in BD across all age ranges, including older adults. Yet, whether high WMH burden is related to the excess cognitive impairment present in older adults with BD is unknown. Therefore, we examine whether higher WMH burden is related to worse cognitive function in older adults with BD.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>This is a cross‐sectional study of 27 non‐demented BD patients aged ≥50 years and 12 similarly aged mentally healthy comparators (controls). Subjects underwent both brain MRI and comprehensive neurocognitive assessment. We employed correlational analyses to evaluate the burden of WMH and the relationship between WMH and cognitive function.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Although BD subjects had worse performance in all cognitive domains, BD subjects had less total WMH burden (\u003Cjats:italic>t\u003C\u002Fjats:italic>[13.4] = −3.57, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.003). In control subjects, higher WMH was related to lower global cognitive function (\u003Cjats:italic>ρ\u003C\u002Fjats:italic> = −0.57, \u003Cjats:italic>n\u003C\u002Fjats:italic> = 12, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.05). However, WMH did not correlate with neuropsychological performance in BD subjects. Further, BD and control subjects did not differ with respect to total gray and hippocampal volumes.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>Cognitive dysfunction in late‐life BD does not appear to be due primarily to processes related to increased WMH or reduced gray matter volume. Future longitudinal studies should examine other potential neuroprogressive pathways such as inflammation, mitochondrial dysfunction, serum anticholinergic burden, and altered neurogenesis. Copyright © 2013 John Wiley & Sons, Ltd.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":1903},"Neuroimaging and neurocognitive abnormalities associated with bipolar disorder in old age",{"VOID":1905},"24006234",{"VOID":1907},"10.1002\u002Fgps.4021",[151],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fgps.4021",[1911,1933,1950,1971,1993,2010,2025,2042],{"id":1912,"sortIndex":179,"researcher":24,"roles":1913,"affiliations":1914,"properties":1926},"b5ca89cd-995e-463a-8c98-4f56cc893245",[],[1915],{"id":1916,"sortIndex":25,"affiliation":1917,"properties":24},"c6f3ba68-fae4-4916-8342-b79fa1f59302",{"id":1918,"createTime":1919,"updateTime":1920,"relativeEntities":1921,"slug":1922,"properties":1923,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"257b12f0-300e-46c8-a7dc-67e8147aa734","2024-07-19T11:45:17.115+00:00","2025-02-04T02:42:23.084+00:00",[],"Department-of-Psychiatry-University-of-Pittsburgh-School-of-Medicine-Pittsburgh-PA-USA",{"title":1924},{"EN":1925},"Department of Psychiatry, University of Pittsburgh School of Medicine; Pittsburgh, PA USA",{"openalex":1927,"orcid":1929,"title":1931},{"VOID":1928},"A5085696063",{"VOID":1930},"https:\u002F\u002Forcid.org\u002F0000-0002-2563-817X",{"EN":1932},"Meryl A. 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of memory loss are a common complaint within the general population and a frequent reason for seeking medical advice. However, the clinical relevance of these symptoms to future development of neurodegenerative disease is uncertain. The aim of this study is to characterise a cohort of individuals with symptoms of memory loss and varying memory impairment, who will be followed longitudinally with serial neuropsychology and neuroimaging to evaluate the clinical relevance of symptoms of memory loss.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Method\u003C\u002Fjats:title>\u003Cjats:p>Fifty‐eight subjects with symptoms of memory loss were recruited from the National Hospital for Neurology and Neurosurgery. All subjects underwent clinical assessment, APOE4 genotyping, neuroimaging and neuropsychological tests.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Those with mild cognitive impairment (MCI) had an increased prevalence of the APOE4 allele, impaired performance on tests of memory, measures of IQ and naming compared to controls. Baseline brain volumes were decreased and ventricular size increased. Those with symptoms of memory loss but no cognitive impairment (SNCI) performed significantly worse on tests of memory than the control group.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>The MCI represent a group with multiple risk factors for progression to AD. The SNCI group may represent a heterogeneous group with some individuals in the early stages of AD whilst others' memory complaints are more likely linked to anxiety or personality traits. Copyright © 2006 John Wiley & Sons, Ltd.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":2222},"Do symptoms of memory impairment correspond to cognitive impairment: a cross sectional study of a clinical cohort",{"VOID":2224},"16977678",{"VOID":2226},"10.1002\u002Fgps.1644",[151],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fgps.1644",[2230,2249,2266,2281,2298,2313,2330,2351,2368],{"id":2231,"sortIndex":179,"researcher":24,"roles":2232,"affiliations":2233,"properties":2244},"512ff7ef-ef70-41ee-8cbe-ba8dc3b0f71e",[],[2234],{"id":2235,"sortIndex":25,"affiliation":2236,"properties":24},"09b8dc2b-8991-4ac5-939b-8c2f0354ad44",{"id":2237,"createTime":2238,"updateTime":2238,"relativeEntities":2239,"slug":2240,"properties":2241,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"b9188e34-6adc-4d9f-a1e4-f7ecb4c28895","2024-09-30T20:18:05.262+00:00",[],"Institute-of-Neurology-Dementia-Research-Centre-London-WC1N-3BG-",{"title":2242},{"EN":2243},"Institute of Neurology, Dementia Research Centre, London, WC1N 3BG.",{"openalex":2245,"title":2247},{"VOID":2246},"A5089658066",{"EN":2248},"F. 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