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The current study was undertaken with the aim of studying the relationship between parathyroid hormone and hyperfunctioning parathyroids by a sophisticated method of analysis. Our clinical study included 25 patients undergoing surgery for primary hyperparathyroidism. The measurement of basal circulating intact PTH (pg\u002Fml) and the volume (mm\u003Cjats:sup>3\u003C\u002Fjats:sup>) of the removed gland(s) were recorded. It was essential for the distribution of the sample values to be normal before Pearson's correlation and regression analysis were performed. The Kolmogorov-Smirnov test showed sufficient sample data agreement (p>20%) with normal distribution after their transformation into natural logarithm (ln) and so statistical analysis was performed utilizing ln transformed data. The regression line between basal ln of iPTH levels (x) and ln of tumor volume (y) was highly significant (y=2.3828+1.0424 x, r=.72504, p<.0001). In our opinion, the above is a correct statistical procedure with reliable results. \u003C\u002Fjats:p>",{"EN":525},"A Controversial Problem: Is There a Relationship between Parathyroid Hormone Level and Parathyroid Size in Primary Hyperparathyroidism?",{"VOID":527},"9479592",{"VOID":529},"10.1177\u002F172460089701200304",[181],"https:\u002F\u002Fjournals.sagepub.com\u002Fdoi\u002F10.1177\u002F172460089701200304",[533,552,573,588,619],{"id":534,"sortIndex":25,"researcher":24,"roles":535,"affiliations":536,"properties":547},"6146e819-4cce-4a30-a420-ef5a20260f7e",[],[537],{"id":538,"sortIndex":25,"affiliation":539,"properties":24},"b282ff30-f594-4cf8-9889-cc083080d446",{"id":540,"createTime":541,"updateTime":541,"relativeEntities":542,"slug":543,"properties":544,"entityType":77,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"c72dd35f-abc5-47f2-816c-b40cc50e5aae","2025-02-03T20:32:25.657+00:00",[],"Nuclear-Medicine-University-of-Firenze-Firenze-Italy",{"title":545},{"EN":546},"Nuclear Medicine, University of Firenze, Firenze - 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New York: McGraw-Hill Publishers 1956; 47–51.",{},{"id":735,"createTime":736,"updateTime":736,"relativeEntities":737,"slug":738,"properties":739,"entityType":176,"verifyStatus":177,"verifyTime":736,"verifyNote":179,"syncStatus":23,"languages":753,"translateLanguages":24,"viewCount":25,"primaryUrl":754,"fullTextUrl":24,"authors":755,"publicationType":358,"publisherRelationship":1045,"citationCount":151,"citationInfo":1082,"publishDate":1084,"publishYear":1085,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1086,"isForceReanalyzing":510},"34241946-a392-4000-9503-20a55128e7c1","2024-10-09T18:44:26.938+00:00",[],"Clinicopathological-and-molecular-differences-in-colorectal-cancer-according-to-location",{"mag":740,"keywords":742,"openalex":743,"abstract":745,"title":747,"pm":749,"doi":751},{"VOID":741},"2920813333",{},{"VOID":744},"W2920813333",{"EN":746},"\u003Cjats:sec>\u003Cjats:title>Purpose:\u003C\u002Fjats:title>\u003Cjats:p> The incidence, pathogenesis, molecular pathways, and outcomes of colorectal cancer vary depending on the location of the tumor. This study aimed to compare the difference in tumor characteristics and the outcome between right-sided colon cancer and left-sided colorectal cancer (LCRC). \u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Materials and methods:\u003C\u002Fjats:title>\u003Cjats:p> A total of 1503 patients with colorectal cancer who underwent surgery at the Taipei Veterans General Hospital between 2000 and 2010 were enrolled in this study. Right-sided colon cancer was defined as cancers in the cecum, ascending colon, and transverse colon, while LCRC was defined as cancers in the splenic flexure colon, descending colon, sigmoid colon, and rectum. The endpoint was overall survival. The mutations were detected via polymerase chain reaction and MASS array. The prognostic value was determined using the log-rank test and the Cox regression analysis. \u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results:\u003C\u002Fjats:title>\u003Cjats:p> A total of 407 and 1096 cases were classified as right-sided colon cancer and LCRC, respectively. Compared to patients with LCRC, those with right-sided colon cancer had more mucinous type cancer (7.4% vs. 3.5%), poorly differentiated tumor (11.5% vs. 3.6%), and advanced tumor-node-metastasis stage. The risk for peritoneal tumor seeding was higher in the right-sided colon cancer group (12.8% vs. 5.7%). Overall survival was better in LCRC than in right-sided colon cancer ( P=0.036). \u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions:\u003C\u002Fjats:title>\u003Cjats:p> In our study, right-sided colon cancer had a more advanced tumor stage, a higher risk of peritoneal metastasis, and a poorer outcome than LCRC. 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Findings from recent studies suggest that obesity may be associated with an increased risk of endometrial cancer, but several earlier studies were less conclusive. Here we strive to estimate this relationship in a meta-analysis of published data. \u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p> We searched Pubmed and Embase for studies on body mass index and the risk of endometrial cancer, published from 1989 to 2011. Data were independently extracted and analyzed using random or fixed effects meta-analysis depending on the degree of heterogeneity. \u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p> Seven cohort studies and 11 case-control studies were included in the meta-analysis. Overall, the conditions of excess body weight ([EBW] defined as body mass index [BMI] ≥25 kg\u002Fm\u003Cjats:sup>2\u003C\u002Fjats:sup>), obesity (BMI ≥30 kg\u002Fm\u003Cjats:sup>2\u003C\u002Fjats:sup>) and overweight (25< BMI <30 kg\u002Fm\u003Cjats:sup>2\u003C\u002Fjats:sup>) were associated with an increased risk of endometrial cancer (relative risk [RR] for EBW=1.62, 95% confidence interval [CI], 1.39-1.89; for obesity RR=2.54, 95% CI, 2.11-3.06; for overweight RR=1.32, 95% CI, 1.16-1.50). Subgroup analyses showed that the positive associations were independent of study design, geographic locations, self-reported BMI, alcohol use, smoking habit, history of diabetes, hormone therapy, age at menarche, age at menopause, parity, and age at first full term pregnancy. However, there was no statistically significant association between EBW and endometrial cancer risk for measured BMI (for EBW RR=1.29, 95% CI, 0.66-2.53). \u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p> The findings from this meta-analysis strongly support that the conditions of EBW, overweight, and obesity are all associated with an increased risk of endometrial cancer. Also, the strength of the association increases with increasing BMI. \u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":1173},"Overweight, Obesity and Endometrial Cancer Risk: Results from a Systematic Review and 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We also assessed the most widely used pancreatic tumor markers, carbohydrate antigen 19–9 (CA 19–9) and carcinoembryonic antigen (CEA), in both groups. We then correlated the concentrations of the cytokines and the tumor markers in the patients’ serum and we estimated their diagnostic ability by calculating diagnostic sensitivity and specificity, positive and negative predictive values and the receiver operating characteristic (ROC) curve. \u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p> The SCF and IL-3 levels were significantly lower and the M-CSF levels significantly higher in pancreatic cancer patients than in controls. There were significant positive correlations between the serum levels of CEA and M-CSF, GM-CSF and SCF, and between GM-CSF and IL-3. The area under the ROC curve and diagnostic sensitivity of M-CSF were greater than those of SCF and IL-3. 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