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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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blastoma (PB) is a rare biphasic neoplasm. Surgery is the preferred treatment with no consensus on the role of other therapies. We report the clinicopathologic features of PB in three patients. We reviewed the medical records of patients diagnosed with PB at Jackson Memorial Hospital, Miami, FL, since 2009–2012. The mean age at diagnosis was 53 years; two were male and both were heavy smokers. At diagnosis, all cases were symptomatic; two were stage IV with metastatic disease. Two out of three patients were treated with absolute curative surgical resection and both patients had no evidence of disease. Patient with stage IV and resection relapsed in 28 months, received chemotherapy and then radiation without response and died after 33 months. The other surgical patient has no evidence of disease at the end of this study. The patient with unresectable disease received chemotherapy alone attaining partial response. Pathologically, all cases showed biphasic morphology composed of epithelial and spindle cell stroma with mesenchymal differentiation. Immunohistochemical analysis revealed positivity in all cases for thyroid transcription factor, keratin, and epithelial membrane antigen in the epithelial component and negative in the mesenchymal component. In conclusion, surgery was the most beneficial intervention. Chemotherapy has shown mixed responses which is consistent with the literature. Targeted therapies should be explored as additional treatment options in PB.",{"EN":929},"Pulmonary blastoma: a clinicopathologic study of 3 cases and review of literature",{"VOID":931},"Koss MN, Hochholezer L, O’Leary T (1991) Pulmonary blastomas. Cancer 67:2368–2381\nWick MR, Allen TC, Leslie KO et al (2011) Special variants of sarcomatoid carcinoma of the lung. In: Leslie KO, Wick MR (eds) Practical pulmonary pathology, 2nd edn. Elsevier, Philadelphia, pp 445–505\nCulter CS, Michel RP, Yssa M et al (1998) Pulmonary blastoma: case report of patient with 7-year remission and review of chemotherapy experience in the world literature. Cancer 82:462–467\nColby TV, Koss MN, Travis WD (1995) Tumors of the lower respiratory tract. American Registry of Pathology, 3rd edn. Armed Forces Institute of Pathology, Maryland, pp 395–417\nBarret NR, Barnard WG (1944) Some unusual thoracic tumors. Br J Surg 32:447–457\nSpencer H (1961) Pulmonary blastomas. J Pathol Bacteriol 82:161–165\nMedburry CA III, Bibro MC, Phares JC et al (1984) Pulmonary blastoma: case report and literature review of chemotherapy experience. Cancer 53:2413–2416\nBodner SM, Koss MN (1996) Mutations in the p53 gene in pulmonary blastomas: immunohistological and molecular studies. Hum Pathol 27:1117–1122\nSchiwitter M, Potocnik P, Von Moos R et al (2011) Dyspnoea and a lung mass in a young female 2 weeks after Caesarean delivery. Eur Respir J 38:465–479\nZuker NB, Dietl CA, Kenna S et al (2007) Unusual survival of an adult with pleuropulmonary blastoma and neurofibromatosis. J Thorac Cardiovasc Surg 134:541–542\nCluzeau T, Sirvent A, Lassalle S et al (2010) Pneumoblastoma: a rare lung tumour occurring as a long-term complication after allogeneic haematopoietic cell transplantation. Bone Marrow Transplant 45:197–198\nSurmont VF, van Klaveren RJ, Nowak P et al (2002) Unexpected response of a pulmonary blastoma on radiotherapy: a case report and review of the literature. Lung Cancer 36:207–211\nMahon BM, Placido JB, Gattuso P (2009) Fine-needle aspiration of classic biphasic pulmonary blastoma. Diagn Cytopathol 36:427–429\nNakayama T, Ohtsuka T, Kazama A et al (2012) Classic pulmonary blastoma: a subtype of biphasic pulmonary blastoma. Ann Thorac Cardiovasc Surg 18(2):125–127\nTravis WD, Brambilla E, Muller-Hermelink HK et al (2004) World Health Organization classifications of tumors. Pathology and genetics of lung, pleura, thymus and heart. IARC, Lyon, pp 53–58\nNovortny JE, Huras CM (1995) Resection and adjuvant chemotherapy of pulmonary blastoma: a case report. Cancer 76:1537–1539\nBini A, Ansaloni L, Granim G et al (2001) Pulmonary blastoma: report of two cases. Surg Today 31:438–442\nRoberta John, Pacheb Jean-Claude, Seiumc Yodit, de Perrota Marc, Spiliopoulos Anastase (2002) Pulmonary blastoma: report of five cases and identification of clinical features suggestive of the disease. Eur J Cardiothorac Surg 22:708–711\nMulamalla K, Truskinovsky A, Dudek A (2007) Pulmonary blastoma with renal metastasis responds to sorafenib. J Thorac Oncol 2:344–347\nThe International Pleuropulmonary Blastoma Registry. Available from http:\u002F\u002Fwww.ppbregistry.org\u002F\nLarsen H, Sorensen JB (1996) Pulmonary blastoma: a review with special emphasis on prognosis and treatment. Cancer Treat Rev 22:145–160\nIndolfi P, Calsale F, Carli M et al (2000) Pleuropulmonary blastoma. Management and prognosis of 11 cases. Cancer 89:1396–1401\nZagar TM, Blackwell S, Crawford J et al (2010) Preoperative radiation therapy and chemotherapy for pulmonary blastoma. J Thorac Oncol 5:282–283\nLindent C, Vanhuyse M, Thebaud E et al (2011) Pulmonary blastoma in adult: dramatic but transient response to doxorubicin plus ifosfamide. Acta Oncol 50:156–157\nHansen T, Bittinger F, Kortsik C et al (2004) Expression of KIT (CD 117) in biphasic pulmonary blastoma: novel data on histogenesis. Lung 181:193–200\nTheegarten D, Zorn M, Philippou S (1998) Proliferative activity, p53 accumulation and neoangiogenesis in pulmonary carcinosarcomas and pulmonary blastomas. Gen Diagn Pathol 143:265–270\nOzkaynak A, Ortega JA, Laug W et al (1990) Role of chemotherapy in pediatric pulmonary blastoma. Med Pediatr Oncol 18(1):53–56\nZaidi A, Zamavar V, Macbeth F et al (2004) Pulmonary blastoma; medium-term results from a regional center. Am Thorac Surg 73:1572–1575\nCalabria R, Srikanth MS, Chamberlin K et al (1993) Management of pulmonary blastoma in children. Am Surg 59(3):192–196\nPriest JR, McDermott MB, Bhatia S et al (1997) Pleuropulmonary blastoma, a clinicopathologic study of 50 cases. Cancer 80:147–161",{"VOID":933},"10.1007\u002Fs13691-014-0197-z","PUBLICATION","Auto Verify","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs13691-014-0197-z",[938,954,969,982,997,1012,1025],{"id":939,"sortIndex":32,"researcher":28,"roles":940,"affiliations":942,"properties":951},"2ee8488d-01e0-4bcf-b155-d6d5989a50fd",[941],"AUTHOR",[943],{"id":944,"sortIndex":32,"affiliation":945,"properties":28},"9faac395-880f-493f-9df8-5645c76cd61e",{"id":944,"createTime":28,"updateTime":28,"relativeEntities":946,"slug":28,"properties":947,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":950,"statistic":28},[],{"title":948},{"VI":949},"Division of Hematology\u002FOncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, USA",[],{"title":952},{"VI":953},"Damien M. Hansra",{"id":955,"sortIndex":40,"researcher":28,"roles":956,"affiliations":957,"properties":966},"b2dc7bc0-26a2-44c7-8514-0877431301e3",[941],[958],{"id":959,"sortIndex":32,"affiliation":960,"properties":28},"1040584d-2db5-49e4-a730-409a5067e714",{"id":959,"createTime":28,"updateTime":28,"relativeEntities":961,"slug":28,"properties":962,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":965,"statistic":28},[],{"title":963},{"VI":964},"Department of Medicine, Jackson Memorial Medical Center, Miami, USA",[],{"title":967},{"VI":968},"Mario Ponce",{"id":970,"sortIndex":123,"researcher":28,"roles":971,"affiliations":972,"properties":979},"d5cdc745-99e1-493b-825a-5a97f5c3296f",[941],[973],{"id":959,"sortIndex":32,"affiliation":974,"properties":28},{"id":959,"createTime":28,"updateTime":28,"relativeEntities":975,"slug":28,"properties":976,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":978,"statistic":28},[],{"title":977},{"VI":964},[],{"title":980},{"VI":981},"Jose D. Sandoval-Sus",{"id":983,"sortIndex":42,"researcher":28,"roles":984,"affiliations":985,"properties":994},"4207417f-99b9-4569-b073-087a0f7f948c",[941],[986],{"id":987,"sortIndex":32,"affiliation":988,"properties":28},"d703f65c-0794-4e52-9902-21588713b5f5",{"id":987,"createTime":28,"updateTime":28,"relativeEntities":989,"slug":28,"properties":990,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":993,"statistic":28},[],{"title":991},{"VI":992},"Department of Pathology, University of Miami Miller School of Medicine\u002FJackson Memorial Hospital, Miami, USA",[],{"title":995},{"VI":996},"Maureen Cioffi-Lavina",{"id":998,"sortIndex":45,"researcher":28,"roles":999,"affiliations":1000,"properties":1009},"98754f15-9be9-4b30-9e85-e301c868eed5",[941],[1001],{"id":1002,"sortIndex":32,"affiliation":1003,"properties":28},"17556c59-8c2b-47ad-9a88-4a523fcc07cd",{"id":1002,"createTime":28,"updateTime":28,"relativeEntities":1004,"slug":28,"properties":1005,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1008,"statistic":28},[],{"title":1006},{"VI":1007},"University of Miami Miller School of Medicine, Miami, USA",[],{"title":1010},{"VI":1011},"Ravi Patel",{"id":1013,"sortIndex":46,"researcher":28,"roles":1014,"affiliations":1015,"properties":1022},"45d3dbe0-d24b-42e7-a41b-fbb928e8469c",[941],[1016],{"id":987,"sortIndex":32,"affiliation":1017,"properties":28},{"id":987,"createTime":28,"updateTime":28,"relativeEntities":1018,"slug":28,"properties":1019,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1021,"statistic":28},[],{"title":1020},{"VI":992},[],{"title":1023},{"VI":1024},"Ikpat F. Offiong",{"id":1026,"sortIndex":48,"researcher":28,"roles":1027,"affiliations":1028,"properties":1037},"7ae6698a-0de0-4efb-bf06-0c0df79f5c7b",[941],[1029],{"id":1030,"sortIndex":32,"affiliation":1031,"properties":28},"fd1dd38b-0952-4f3d-aaba-c0b04f5ecfef",{"id":1030,"createTime":28,"updateTime":28,"relativeEntities":1032,"slug":28,"properties":1033,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1036,"statistic":28},[],{"title":1034},{"VI":1035},"The Center for Hematology Oncology, Lynn Cancer Institute, Boca Raton, USA",[],{"title":1038},{"VI":1039},"Edgardo S. 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However, the prognosis of this aggressive tumor is poor with short survival after diagnosis. We are describing in this manuscript a case of pure large cell neuroendocrine carcinoma in which survival exceeded 26 months, after performing two curative surgeries. We are reporting the case of a 68-year-old woman with a history of recovered right breast carcinoma and operated 6 years later for a completely asymptomatic gallbladder tumor of 31 mm. In this case, curative surgery was performed allowing monobloc resection of the gallbladder and the hepatic segments IVb and V, a lymph node dissection was performed to. The histological examination of the specimen and immunohistochemistry confirms that the tumor was a grade 3 pure large cell neuroendocrine carcinoma of gallbladder with lymph node invasion, the hepatic and biliary surgical margins were free. Postoperative adjuvant chemotherapy was administered and the evolution was eventless until the discovery at 20 months of a lymph node considered being metastatic recurrence. A second surgery was performed allowing removal of three lymph nodes. This time, a different protocol of chemotherapy was administered to our patient who remains alive and without recurrence at 26 months from her first surgery. Surgical relentlessness with free margins resections associated with appropriate chemotherapy probably improves the survival of patients suffering from this rare and aggressive tumor.",{"EN":1088},"Pure large cell neuroendocrine carcinoma of the gallbladder, is surgical relentlessness beneficial? A case report and literature review",{"VOID":1090},"Choe J, Kim KW, Kim HJ, Kim DW, Kim KP, Hong S-M et al (2019) What Is New in the 2017 world health organization classification and 8th American joint committee on cancer staging system for pancreatic neuroendocrine neoplasms? Korean J Radiol 20(1):5\nYao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE et al (2008) One hundred years after ‘carcinoid’: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 26(18):3063–3072\nHadoux J, Blanchard P, Scoazec J-Y, Burtin P, Planchard D, Malka D et al (2019) Post radiation grade 3 neuroendocrine carcinoma (PRNEC): a new entity? Neuroendocrinology 22:120–134\nHamdi Cherif M, Bidoli E, Birri S, Mahnane A, Zaidi Z et al (2015) Cancer estimation of incidence and survival in Algeria 2014. J Cancer Res Thera 3(9):100–104\nAyabe RI, Wach M, Ruff S, Martin S, Diggs L, Wiemken T et al (2019) Primary gallbladder neuroendocrine tumors: insights into a rare histology using a large national database. Ann Surg Oncol 26(11):3577–3585\nPapotti M, Cassoni P, Sapino A, Passarino G, Krueger JE, Albores-Saavedra J (2000) Large cell neuroendocrine carcinoma of the gallbladder: report of two cases. Am J Surg Pathol 24(10):1424–1428\nHaji G, Nabizade U, Kazimov K, Guliyeva N, Isayev I (2019) Liver dose reduction by deep inspiration breath hold technique in right-sided breast irradiation. Radiat Oncol J 37(4):254–258\nMiyamoto R, Kikuchi K, Uchida A, Ozawa M, Nagai K, Maeda M et al (2016) Large cell neuroendocrine carcinoma of the gallbladder: a case report and literature review. Int Surg 101(9–10):458–464\nJun SR, Lee JM, Han JK, Choi BI (2006) High-grade neuroendocrine carcinomas of the gallbladder and bile duct: report of four cases with pathological correlation. J Comput Assist Tomogr 30(4):604–609\nKim T-H, Kim SH, Lee KB, Han JK (2017) Outcome and CT differentiation of gallbladder neuroendocrine tumours from adenocarcinomas. Eur Radiol 27(2):507–517\nOkuyama Y, Fukui A, Enoki Y, Morishita H, Yoshida N, Fujimoto S (2013) A large cell neuroendocrine carcinoma of the gall bladder: diagnosis with 18FDG-PET\u002FCT-guided biliary cytology and treatment with combined chemotherapy achieved a long-term stable condition. Jpn J Clin Oncol 43(5):571–574\nGarcia-Carbonero R, Sorbye H, Baudin E, Raymond E, Wiedenmann B, Niederle B et al (2016) ENETS consensus guidelines for high-grade gastroenteropancreatic neuroendocrine tumors and neuroendocrine carcinomas. Neuroendocrinology 103(2):186–194\nEilard MS, Lundgren L, Cahlin C, Strandell A, Svanberg T, Sandström P (2017) Surgical treatment for gallbladder cancer – a systematic literature review. Scand J Gastroenterol 52(5):505–514\nSpada F, Antonuzzo L, Marconcini R, Radice D, Antonuzzo A, Ricci S et al (2016) Oxaliplatin-based chemotherapy in advanced neuroendocrine tumors: clinical outcomes and preliminary correlation with biological factors. Neuroendocrinology 103(6):806–814\nAuernhammer CJ, Spitzweg C, Angele MK, Boeck S, Grossman A, Nölting S et al (2018) Advanced neuroendocrine tumours of the small intestine and pancreas: clinical developments, controversies, and future strategies. Lancet Diabetes Endocrinol 6(5):404–415\nHentic O, Hammel P, Couvelard A, Rebours V, Zappa M, Palazzo M et al (2012) FOLFIRI regimen: an effective second-line chemotherapy after failure of etoposide-platinum combination in patients with neuroendocrine carcinomas grade 3. Endocr Relat Cancer 19(6):751–757\nIype S, Mirza TA, Propper DJ, Bhattacharya S, Feakins RM, Kocher HM (2009) Neuroendocrine tumours of the gallbladder: three cases and a review of the literature. Postgrad Med J 85(1002):213\nAbutaka A, El-Matbouly M, Helmy I, Elmoghazy W, Sulieman I, Ben Gashir M et al (2019) Repeat liver resection for pure large cell neuroendocrine carcinoma of the gallbladder: a favorable outcome. World J Surg Oncol 17(1):126\nShimono C, Suwa K, Sato M, Shirai S, Yamada K, Nakamura Y et al (2009) Large cell neuroendocrine carcinoma of the gallbladder: long survival achieved by multimodal treatment. Int J Clin Oncol 14(4):351–355\nShapera E, Bitting C (2019) Survival : a rare outcome in large cell neuroendocrine carcinoma of the gallbladder. Acta Gastroenterol Belg 82(3):433–436\nFujii M, Saito H, Shiode J (2019) Rare case of a gallbladder neuroendocrine carcinoma. Clin J Gastroenterol 12(1):38–45",{"VOID":1092},"10.1007\u002Fs13691-020-00461-z","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs13691-020-00461-z",[1095,1110,1123,1138,1153,1166,1179],{"id":1096,"sortIndex":32,"researcher":28,"roles":1097,"affiliations":1098,"properties":1107},"0a00802b-99a0-49ba-b04f-38063d8dd8ba",[941],[1099],{"id":1100,"sortIndex":32,"affiliation":1101,"properties":28},"4df7c635-0583-4b8c-b836-45b3ad56be03",{"id":1100,"createTime":28,"updateTime":28,"relativeEntities":1102,"slug":28,"properties":1103,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1106,"statistic":28},[],{"title":1104},{"VI":1105},"Department of Hepatobiliary Surgery and Liver Transplantation, EHU-1st November 1954, Department of Medicine, University of Oran 1, Oran, Algeria",[],{"title":1108},{"VI":1109},"Anisse 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present a case of primary pulmonary synovial sarcoma in a 41-year-old female. A well-defined round nodule was pointed out in her right upper lobe on routine chest X-ray and computed tomography. Fluorodeoxyglucose positron emission tomography (FDG-PET) showed mild uptake with a maximum standardized uptake value of 2.5 at the lung nodule. No other abnormal FDG uptake was detected. As our preoperative diagnosis was benign lung tumor, we performed partial lung resection. However, the pathological diagnosis was a malignant tumor which consisted of spindle cells with very high mitotic activity. We suspected synovial sarcoma by the result of histological findings and immunohistochemical examination. Finally, an SYT-SSX1 fusion gene transcript was finally detected by reverse transcriptase polymerase chain reaction analysis. On the basis of these findings, we diagnosed primary pulmonary synovial sarcoma of monophasic fibrous type. Then completion right upper lobectomy was performed, she is alive and has been disease-free for 2 years.",{"EN":1240},"A surgical case of primary pulmonary synovial sarcoma confirmed by the detection of an SYT-SSX1 fusion gene",{"VOID":1242},"Travis WD, Travis LB, Devesa SS (1995) Lung cancer. Cancer 75:191–202\nKawai A, Woodruff J, Healey JH et al (1998) SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. N Engl J Med 338:153–160\nFrazier AA, Franks TJ, Pugatch RD et al (2006) From the archives of the AFIP: pleuropulmonary synovial sarcoma. Radiographics 26:923–940\nFletcher CDM, Unni K, Mertens F (2002) Pathology and genetics of tumours of soft tissue and bone, World Health Organization Classification of Tumours. IARC, Lyon, p 427\nClark J, Rocques PJ, Crew AJ et al (1994) Identification of novel genes, SYT and SSX, involved in the t(X; 18) (p11.2; q11.2) translocation found in human synovial sarcoma. Nat Genet 7:502–508\nGuillou L, Coindre J, Gallagher G et al (2001) Detection of the synovial sarcoma translocation t(X; 18) (SYT; SSX) in paraffin-embedded tissues using reverse transcriptase-polymerase chain reaction: a reliable and powerful diagnostic tool for pathologists. A molecular analysis of 221 mesenchymal tumors fixed in different fixatives. Hum Pathol 32:105–112\nJanssen JP, Mulder JJ, Wagenaar SS et al (1994) Primary sarcoma of the lung: a clinical study with long-term follow-up. Ann Thorac Surg 58:1151–1155\nTrassard M, Le Doussal V, Hacène K et al (2001) Prognostic factors in localized primary synovial sarcoma: a multicenter study of 128 adult patients. J Clin Oncol 19:525–534\nBergh P, Meis-Kindblom JM, Gherlinzoni F, et al. Synovial sarcoma: identification of low and high risk groups",{"VOID":1244},"10.1007\u002Fs13691-013-0131-9","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs13691-013-0131-9",[1247,1262,1275,1288,1301],{"id":1248,"sortIndex":32,"researcher":28,"roles":1249,"affiliations":1250,"properties":1259},"6742dcef-903f-4f63-b008-d99d3f8d6ae2",[941],[1251],{"id":1252,"sortIndex":32,"affiliation":1253,"properties":28},"8adb7574-1299-4fbc-8f87-2b304c1cc598",{"id":1252,"createTime":28,"updateTime":28,"relativeEntities":1254,"slug":28,"properties":1255,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1258,"statistic":28},[],{"title":1256},{"VI":1257},"Department of Thoracic Surgery, Hyogo College of Medicine, Nishinomiya, Japan",[],{"title":1260},{"VI":1261},"Masaki Hashimoto",{"id":1263,"sortIndex":40,"researcher":28,"roles":1264,"affiliations":1265,"properties":1272},"7376c5e5-3067-4e51-b839-33650ae94ae4",[941],[1266],{"id":1252,"sortIndex":32,"affiliation":1267,"properties":28},{"id":1252,"createTime":28,"updateTime":28,"relativeEntities":1268,"slug":28,"properties":1269,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1271,"statistic":28},[],{"title":1270},{"VI":1257},[],{"title":1273},{"VI":1274},"Nobuyuki 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mesenteric artery (SMA) syndrome is a rare disease, characterized by the narrowing of the third portion of the duodenum between the aorta and SMA. The cause of the stenosis is a decrease in retroperitoneal fat between the aorta and SMA. In this report, we present two cases of SMA syndrome that occurred during chemotherapy for lung cancer. The first case was a 61-year-old male treated with nanoparticle albumin-bound-paclitaxel (nab-PTX) for lung adenocarcinoma. On day 23 of the first course of nab-PTX, he was admitted to our hospital due to vomiting and weight loss of 15.6 kg in 10 months. He was diagnosed with SMA syndrome through computed tomography, and drainage was performed using a nasogastric tube. Conservative treatment was successful, and the patient was able to continue therapy with nab-PTX. The second case was a 70-year-old male with epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer. He was admitted to our hospital due to vomiting and dizziness while receiving treatment with pembrolizumab, as well as weight loss of 14.6 kg in 6 months. He was diagnosed with SMA syndrome using computed tomography. Conservative treatment using a nasogastric tube led to improvement, and the patient was able to continue treatment with pembrolizumab after discharge. This is the first report of SMA syndrome in patients with lung cancer undergoing chemotherapy with nab-PTX or pembrolizumab. Late diagnosis and treatment render SMA syndrome a potentially fatal disease. Vomiting and weight loss during chemotherapy are known treatment-related side effects; in patients developing these adverse effects, the presence of SMA syndrome should be suspected and managed appropriately.",{"EN":1362},"Two cases of superior mesenteric artery syndrome during chemotherapy in patients with lung cancer",{"VOID":1364},"Welsch T, Büchler MW, Kienle P (2007) Recalling superior mesenteric artery syndrome. Dig Surg 24:149–156\nMatheus Cde O, Waisberg J, Zewer MH, Godoy AC (2005) Syndrome of duodenal compression by the superior mesenteric artery following restorative proctocolectomy: a case report and review of literature. Sao Paulo Med J 123:151–153\nYoung A, Kinnear N, Hennessey D et al (2018) Intermittent superior mesenteric artery syndrome in a patient with multiple sclerosis. Radiol Case Rep 13:1108–1111\nHaidar A, Davies A, Hussain A et al (2020) Wilkie’s weight loss wonder, a case series. Spartan Med Res J 15:13485\nShi Y, Shi G, Li Z et al (2019) Superior mesenteric artery syndrome coexists with Nutcracker syndrome in a female: a case report. BMC Gastroenterol 19:15\nUshiki A, Koizumi T, Yamamoto H et al (2012) Superior mesenteric artery syndrome following initiation of cisplatin-containing chemotherapy: a case report. J Med Case Rep 6:14\nChowdhary M, Pansuria HP, Farooqi B et al (2015) Superior mesenteric artery syndrome: a unique complication following carboplatin-based chemotherapy. Int Med Case Rep J 8:55–58\nAhmed AR, Taylor I (1997) Superior mesenteric artery syndrome. Postgrad Med J 73:776–778\nIwaoka Y, Yamada M, Takehira Y et al (2001) Superior mesenteric artery syndrome in identical twin brothers. Intern Med 40(8):713–715\nMerrett ND, Wilson RB, Cosman P et al (2009) Superior mesenteric artery syndrome: diagnosis and treatment strategies. J Gastrointest Surg 13:287–292\nGanss A, Rampado S, Savarino E et al (2019) Superior mesenteric artery syndrome: a prospective study in a single institution. J Gastrointest Surg 23:997–1005\nUnal B, Aktaş A, Kemal G et al (2005) Superior mesenteric artery syndrome: CT and ultrasonography findings. Diagn Interv Radiol 11:90–95\nNeri S, Signorelli SS, Mondati E et al (2005) Ultrasound imaging in diagnosis of superior mesenteric artery syndrome. J Intern Med 257:346–351\nChang J, Boules M, Rodriguez J et al (2017) Laparoscopic duodenojejunostomy for superior mesenteric artery syndrome: intermediate follow-up results and a review of the literature. Surg Endosc 31:1180–1185\nDeshpande SH, Thomas J, Chiranjeev R, et al (2021) Superior mesenteric artery syndrome in a patient with celiacomesenteric trunk. BMJ Case Rep 14:e237132.\nSalem A, Al Ozaibi L, Nassif SMM et al (2017) Superior mesenteric artery syndrome: A diagnosis to be kept in mind (case report and literature review). 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phlebosclerosis is a recently discovered rare ischemic colon disease. The relationship between mesenteric phlebosclerosis and the use of herbal medicine containing gardenia fruit was recently reported. Although the relationship between colon cancer and mesenteric phlebosclerosis has not been described, some cases of colorectal cancer coincident with mesenteric phlebosclerosis have been reported. We treated a 63-year-old female who was diagnosed with ascending colon cancer coincident with mesenteric phlebosclerosis. She had been taking a Chinese herb containing gardenia fruit for over 18 years. The ascending colon cancer was clinically diagnosed as T2, N0, and M0 according to Japanese classification of colorectal carcinoma and the mesenteric phlebosclerosis had spread from the cecum to the descending colon. She underwent laparoscopic subtotal colectomy with en bloc removal of the regional lymph nodes, and both the ascending colon cancer and mesenteric phlebosclerosis were completely resected. The microscopic findings show that the tumor was well-differentiated tubular adenocarcinoma invading the muscular propria with no regional lymph node metastasis, and the mesenteric phlebosclerosis lesion was characterized by marked fibrous thickening of the venous walls with calcification, marked transmural fibrosis and deposition of the collagen in the mucosa, accompanied by macrophages within the vessel walls. In literature review, 10 cases with colorectal cancer coincident with mesenteric phlebosclerosis were reported. 9 of 10 cases (90%) had cancer in the right-side colon affected by mesenteric phlebosclerosis, and 5 of 10 cases (50%) were associated with the use of a Chinese herb containing gardenia fruit. It was recently demonstrated that genipin, which is a metabolite bio-transformed from gardenia fruit, possesses carcinogenesis. We speculate that genipin may be associated with not only the development of mesenteric phlebosclerosis but also carcinogenesis in the right-side colon. In conclusion, our findings suggest that the safety of gardenia fruit should be re-evaluated, and gastroenterologists should be aware that gardenia fruit may be risk factor for not only the development of mesenteric phlebosclerosis but also carcinogenesis in the proximal colon.",{"EN":1523},"Ascending colon cancer coincident with mesenteric phlebosclerosis associated with the long-term oral intake of Chinese herb containing gardenia fruit: A case report and literature review",{"VOID":1525},"Koyama N, Koyama H, Hanajima T et al (1991) Chronic ischemic colitis causing stenosis: report of a case. Stomach Intest 26:455–456 (Japanese with English abstract)\nIwashita A, Takemura S, Yamada Y et al (1993) Pathomorphologic study on ischemic lesions of the small and large intestine. Stomach Intest 28:927–941 (Japanese with English abstract)\nOshitani N, Matsumura Y, Kono M et al (2002) Asymptomatic chronic intestinal ischemia caused by idiopathic phlebosclerosis of mesenteric vein. Dig Dis Sci 47:2711–2714\nKusanagi M, Matsui O, Kawashima H et al (2005) Phlebosclerotic colitis: imaging-pathologic correlation. Am J Roentgenol 185:441–447\nGuo F, Zhou YF, Zhang F et al (2014) Idiopathic mesentericphlebosclerosis associated with long-term use of medical liquor: two casereports and literature review. World J Gastroenterol 20:5561–5566\nShimizu S, Kobayashi T, Tomioka H et al (2016) Involvement of herbal medicine as a cause of mesenteric phlebosclerosis: results from a large-scale nationwide survey. J Gastroenterol 51:1–7\nShimizu K, Nishimura Z, Mitida T et al (2000) A case of ischemic intestinal lesion caused by phlebosclerosis without clinical symptoms for three years. J Colon Exam 17:192–195 (Japanese)\nKimura Y, Kashima K, Daa T et al (2003) Phlebosclerotic colitis coincident with carcinoma in adenoma. Pathol Intl 53:721–725\nOta A, Iwashita A, Ikeda K et al (2009) Idiopathic mesenteric phlebosclerosis coincident with adenocarcinoma of the ascending colon, report of a case. Stomach Intest 44(2):227–232 (Japanese with English abstract)\nYamaoku K, Saeki H, Katayama Y et al (2011) A case report on idiopathic mesenteric phlebosclerosis accompanied by carcinoma of the transverse colon. J Jpn Coll Surg 36(6):1020–1026 (Japanese with English abstract)\nHiramatsu K, Sakata H, Horita Y et al (2012) Mesenteric phlebosclerosis associated with long-term oral intake of geniposide, an ingredient of herbal medicine. Aliment Pharmacol Ther 36:575–586\nKomori T, Kato A, Chono A et al (2012) Idiopathic mesenteric phlebosclerosis with ascending colon cancer—a case report. J Jpn Soc Coloproctol 65:124–129 (Japanese with English abstract)\nOmoto T, Tanaka J, Takayanagi D et al (2013) Idiopathic mesenteric phlebosclerosis with transverse colon cancer—a case report (in Japanese). The 68th general meeting of the Japanese Society of Gastroenterological Surgery\nYamazi K, Sumi K, Tanaka S et al (2014) Mesenteric phlebosclerosis coincident with adenocarcinoma of the cecum: a case report. Rinsho Geka 8:1003–1008 (Japanese)\nTani C, Asai K, Miyamoto M et al (2014) A case of idiopathic mesenteric phlebosclerosis with ascending colon cancer treated with laparoscopic colectomy (in Japanese). The 69th annual meeting of the Japan Society of Coloproctology.\nOzaki A, Kitano M, Furusawa N et al (2002) Genotoxicity of gardenia yellow and its components. Food Chem Toxicol 40:1603–1610\nKhanal T, Kim HG, Do MT et al (2014) Genipin induces cyclooxygenase-2 expression via NADPH oxidase, MAPKs, AP-1, and NF-κB in RAW 264.7 cells. Food Chem Toxicol 64:126–134\nJapanese Society for Cancer of the Colon and Rectum (2013) Japanese Classification of Colorectal Carcinoma (Eighth Edition). Kanehara & Co., Ltd., Tokyo\nJapanese Society for Cancer of the Colon and Rectum (2014) Guidelines for the treatment of colorectal cancer. Kanehara & Co., Ltd., Tokyo\nKang MJ, Khanal T, Kim HG et al (2012) Role of metabolism by human intestinal microflora in geniposide-induced toxicity in HepG2 cells. Arch Pharm Res 35:733–738\nNagata Y, Watanabe T, Nagasaka K et al (2016) Clinical Search for undiagnosed mesenteric phlebosclerosis at outpatient Departments Specializing in Herbal (Kampo) Medicine. Intern Med 55:573–581\nNagata Y, Watanabe T, Nagasaka K et al (2016) Total dosage of gardenia fruit used by patients with mesenteric phlebosclerosis. BMC Complement Altern Med 16:207\nAkaoT, Kobayashi K, Aburada M et al (1994) Enzymic studies on the animal and intestinal bacterial metabolism of geniposide. Biol Pharm Bull 17(12):1573–1576\nPapagiorgis PC, Oikonomakis I, Delaportas D et al (2014) Proximal shift of colorectal cancer. A persistent phenomenon with multiple causes, patterns and clinical implications. J BUON 19(3):605–617\nShibutani S, Takeshita M, Grollman AP et al (1991) Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature 349:431–434\nWang D, Dubois RN (2010) Eicosanoids and cancer. 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arising from the peritoneum is extremely rare. We present the case of a 23-year-old woman who underwent urgent laparoscopic surgery because of a pelvic mass and intraperitoneal bleeding. Although peritoneal carcinoma was suspected, pathological re-examination revealed ependymoma with a perivascular pseudorosette and positive for glial fibrillary acidic protein. Residual tumor extraction indicated that the ependymoma had developed from the peritoneum. This case highlights the need to consider ependymoma as a potential diagnosis in young women with suspected ovarian or peritoneal cancer.",{"EN":1714},"A case of ependymoma arising from the peritoneum",{"VOID":1716},"Kleinman GM, Young RH, Scully RE (1984) Ependymoma of the ovary: report of three cases. Hum Pathol 7:632–638\nTavassoli FA, Devilee P (2003) Pathology and genetics of tumors of the breast and female genital organs. Word Health Organization Classification of tumors, 3rd edn. IARC Press, Lyon\nKurman RJ, Carcangiu ML, Herrington CS et al (2014) WHO Classification of tumors of female reproductive organs. Word Health Organization Classification of tumors, 4th edn. IARC Press, Lyon\nDuggan MA, Hugh J, Nation JG, Robertson DI et al (1989) Ependymoma of the uterosacral ligament. Cancer 64:2565–2571\nTakano T, Akahira J, Moriya T et al (2005) Primary ependymoma of the ovary: a case report and literature review. Int J Gynecol Cancer 15:1138–1141\nIdowu MO, Rosenblum MK, Wei XJ et al (2008) Ependymomas of the central nervous system and adult extra-axial ependymomas are morphologically and immunohistochemically distinct–a comparative study with assessment of ovarian carcinomas for expression of glial fibrillary acidic protein. Am J Surg Pathol 5:710–718\nIshihara S, Honda Y, Iyama K (2007) A case of extraneural ependymoma of the abdominal cavity. Jpn J Diagn Pathol 4:440–444\nDeval B, Rousset P, Bigenwald C et al (2014) Treatment of ovarian anaplastic ependymoma by an aromatase inhibitor. Obstet Gynecol 123:488–491\nOkazaki H (1997) A case of ependymoma ovarii. Acta Obst Gynaec Jpn 49:815–817\nMikami M, Yoshii T, Sakaiya N et al (2000) A case of ependymoma of ovary that long term oral administration of VP-16 was effective for prolongation for disease-free interval. Saitama Dist J Jpn Soc Obstet Gynecol 30:25–29 (Article in Japanese)\nMatsuyama A, Hisaoka M, Yamamoto I et al (2010) Extraspinal ependymoma of the broad ligament. Pathol Int 60:241–244\nIshikura H (2006) Ovary. Pathol Clin Med 24:240–246",{"VOID":1718},"10.1007\u002Fs13691-015-0240-8","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs13691-015-0240-8",[1721,1745,1758,1771,1784,1797,1810,1825,1838,1851],{"id":1722,"sortIndex":32,"researcher":28,"roles":1723,"affiliations":1724,"properties":1742},"005bcc1a-7abc-4494-a7e9-395100a623e2",[941],[1725,1733],{"id":1726,"sortIndex":32,"affiliation":1727,"properties":28},"6e9af635-a6e1-48ff-96b1-b6cd0786c926",{"id":1726,"createTime":28,"updateTime":28,"relativeEntities":1728,"slug":28,"properties":1729,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1732,"statistic":28},[],{"title":1730},{"VI":1731},"Department of Gynecologic Oncology, National Hospital Organization, Shikoku Cancer Center, Matsuyama, 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of metastatic malignant melanoma is challenging. Although several new systemic therapies for metastatic malignant melanoma have recently been developed, some patients still also require radiation therapy (RT) for palliative care. However, the safety and efficacy of combining use of novel drugs with RT remain unclear. Here, we report treating a patient with rapidly growing malignant melanoma with a programmed cell death protein 1 (PD-1) inhibitor and a BRAF inhibitor together with 60 Gy of hypofractionated RT without severe adverse effects. The tumor within the radiation field exhibited a more marked response than that outside it. A combination of RT with an anti-PD-1 antibody or a BRAF inhibitor may, therefore, be a useful and tolerable approach to treating metastatic BRAF-mutant melanoma.",{"EN":1962},"Treatment of malignant melanoma with nivolumab and vemurafenib combined with hypofractionated radiation therapy",{"VOID":1964},"Tsao H, Atkins MB, Sober AJ (2004) Management of cutaneous melanoma. N Engl J Med 351:998–1012\nHao M, Song F, Du X et al (2015) Advances in targeted therapy for unresectable melanoma: new drugs and combinations. Cancer Lett 359:1–8\nOvergaard J (1986) The role of radiotherapy in recurrent and metastatic malignant melanoma: a clinical radiobiological study. Int J Radiat Oncol Biol Phys 12:867–872\nSeegenschmiedt MH, Keilholz L, Altendorf-Hofmann A et al (1999) Palliative radiotherapy for recurrent and metastatic malignant melanoma: prognostic factors for tumor response and long-term outcome: a 20-year experience. Int J Radiat Oncol Biol Phys 44:607–618\nReits EA, Hodge JW, Herberts CA et al (2006) Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med 203:1259–1271\nSharabi AB, Lim M, DeWeese TL et al (2015) Radiation and checkpoint blockade immunotherapy: radiosensitisation and potential mechanisms of synergy. Lancet Oncol 16:e498–e509\nTopalian SL, Hodi FS, Brahmer JR et al (2012) Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 366:2443–2454\nLarkin J, Chiarion-Sileni V, Gonzalez R et al (2015) Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med 373:23–34\nRobert C, Long GV, Brady B et al (2015) Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med 372:320–330\nWeber JS, D’Angelo SP, Minor D et al (2015) Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol 16:375–384\nZeng J, See AP, Phallen J et al (2013) Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas. Int J Radiat Oncol Biol Phys 86:343–349\nSharabi AB, Nirschl CJ, Kochel CM et al (2015) Stereotactic radiation therapy augments antigen-specific PD-1-mediated antitumor immune responses via cross-presentation of tumor antigen. Cancer Immunol Res 3:345–355\nChapman PB, Hauschild A, Robert C et al (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364:2507–2516\nSambade MJ, Peters EC, Thomas NE et al (2011) Melanoma cells show a heterogeneous range of sensitivity to ionizing radiation and are radiosensitized by inhibition of B-RAF with PLX-4032. Radiother Oncol 98:394–399\nPeuvrel L, Ruellan AL, Thillays F et al (2013) Severe radiotherapy-induced extracutaneous toxicity under vemurafenib. Eur J Dermatol 23:879–881\nForschner A, Zips D, Schraml C et al (2014) Radiation recall dermatitis and radiation pneumonitis during treatment with vemurafenib. Melanoma Res 24:512–516\nAnker CJ, Ribas A, Grossmann AH et al (2013) Severe liver and skin toxicity after radiation and vemurafenib in metastatic melanoma. J Clin Oncol 31:e283–e287\nHecht M, Zimmer L, Loquai C et al (2015) Radiosensitization by BRAF inhibitor therapy—mechanism and frequency of toxicity in melanoma patients. Ann Oncol 26:1238–1244\nChan MM, Haydu LE, Menzies AM et al (2014) The nature and management of metastatic melanoma after progression on BRAF inhibitors: effects of extended BRAF inhibition. Cancer 120:3142–3153\nHirata E, Girotti MR, Viros A et al (2015) Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1\u002FFAK signaling. 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systemic treatment for hepatocellular carcinoma has advanced after the development of tyrosine kinase inhibitors such as sorafenib and lenvatinib, the effectiveness of a single tyrosine kinase inhibitor in survival extension of unresectable hepatocellular carcinoma is limited to a few months. Therefore, novel treatment options are required for unresectable hepatocellular carcinomas, including those with multiple lung metastases. This case report describes a hepatocellular carcinoma patient with a recurrence of multiple lung metastases, which was successfully treated with conversion pneumonectomy after treatment with tyrosine kinase inhibitors. A 79-year-old man underwent right hepatectomy for hepatocellular carcinoma, along with removal of the tumor thrombus in the inferior vena cava. Multiple lung metastases were detected 4 months after hepatectomy. Treatment with tyrosine kinase inhibitors, mainly lenvatinib, resulted in complete remission of the lung metastases, except for one lesion in segment 3 of the right lung which gradually enlarged. Twenty-three months after hepatectomy, partial resection of the right lung was performed using video-assisted thoracic surgery for this residual lesion in the right lung. The patient remained disease-free for 11 months after conversion pneumonectomy, without any adjuvant therapies. This is the first case report of multiple lung metastases originating from hepatocellular carcinoma which were successfully treated with conversion pneumonectomy after treatment with tyrosine kinase inhibitors. Conversion pneumonectomy after systemic therapy with tyrosine kinase inhibitors should be considered as a treatment strategy for patients with unresectable multiple lung metastases from hepatocellular carcinomas.",{"EN":2095},"Conversion surgery after lenvatinib treatment for multiple lung metastases from hepatocellular carcinoma",{"VOID":2097},"Kudo M, Finn RS, Qin S et al (2018) Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial. Lancet 391:1163–1173. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0140-6736(18)30207-1\nLlovet JM, Ricci S, Mazzaferro V et al (2008) Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 359:378–390. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMoa0708857\nAbbas A, Medvedev S, Shores N et al (2014) Epidemiology of metastatic hepatocellular carcinoma, a nationwide perspective. Dig Dis Sci 59:2813–2820. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs10620-014-3229-9\nUchino K, Tateishi R, Shiina S et al (2011) Hepatocellular carcinoma with extrahepatic metastasis: clinical features and prognostic factors. Cancer 117:4475–4483. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fcncr.25960\nKojima Y, Ueno H, Okusaka T et al (2009) 6610 Hepatocellular carcinoma presenting with lung metastasis: clinical characteristics and prognostic factors. Eur J Cancer Suppl 7:393. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS1359-6349(09)71331-X\nZhang S-M, Zeng Z-C, Tang Z-Y et al (2008) Prognostic analysis of pulmonary metastases from hepatocellular carcinoma. Hepatol Int 2:237–243. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs12072-008-9052-7\nKuo S-W, Chang Y-L, Huang P-M et al (2007) Prognostic factors for pulmonary metastasectomy in hepatocellular carcinoma. Ann Surg Oncol 14:992–997. https:\u002F\u002Fdoi.org\u002F10.1245\u002Fs10434-006-9217-3\nHan KN, Kim YT, Yoon J-H et al (2010) Role of surgical resection for pulmonary metastasis of hepatocellular carcinoma. Lung Cancer 70:295–300. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.lungcan.2010.02.014\nLee CY, Bae MK, Park IK et al (2010) Surgical resection for pulmonary metastasis from hepatocellular carcinoma: analysis of prognosis in relation to primary control. J Surg Oncol 101:239–243. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fjso.21487\nYoon YS, Kim HK, Kim J et al (2010) Long-term survival and prognostic factors after pulmonary metastasectomy in hepatocellular carcinoma. Ann Surg Oncol 17:2795–2801. https:\u002F\u002Fdoi.org\u002F10.1245\u002Fs10434-010-1073-5\nKitano K, Murayama T, Sakamoto M et al (2012) Outcome and survival analysis of pulmonary metastasectomy for hepatocellular carcinoma. Eur J Cardiothorac Surg 41:376–382. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ejcts.2011.05.052\nKow AWC, Kwon CHD, Song S et al (2015) Clinicopathological factors and long-term outcome comparing between lung and peritoneal metastasectomy after hepatectomy for hepatocellular carcinoma in a tertiary institution. Surgery 157:645–653. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.surg.2014.07.024\nMaeda Y, Shinohara T, Nagatsu A et al (2016) Long-term outcomes of conversion hepatectomy for initially unresectable colorectal liver metastases. Ann Surg Oncol 23:S242–S248. https:\u002F\u002Fdoi.org\u002F10.1245\u002Fs10434-015-4460-0\nFolprecht G, Grothey A, Alberts S et al (2005) Neoadjuvant treatment of unresectable colorectal liver metastases: correlation between tumour response and resection rates. Ann Oncol 16:1311–1319. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fannonc\u002Fmdi246\nTomasello G, Petrelli F, Ghidini M et al (2017) FOLFOXIRI plus bevacizumab as conversion therapy for patients with initially unresectable metastatic colorectal cancer: a systematic review and pooled analysis. JAMA Oncol 3:e170278. https:\u002F\u002Fdoi.org\u002F10.1001\u002Fjamaoncol.2017.0278\nKinoshita J, Yamaguchi T, Moriyama H et al (2021) Current status of conversion surgery for stage IV gastric cancer. Surg Today 51:1736–1754. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00595-020-02222-0\nMorgagni P, Solaini L, Framarini M et al (2018) Conversion surgery for gastric cancer: a cohort study from a western center. Int J Surg 53:360–365. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijsu.2018.04.016\nTakahashi K, Kim J, Takahashi A et al (2021) Conversion hepatectomy for hepatocellular carcinoma with main portal vein tumour thrombus after lenvatinib treatment: a case report. World J Hepatol 13:384–392. https:\u002F\u002Fdoi.org\u002F10.4254\u002Fwjh.v13.i3.384\nYokoo H, Takahashi H, Hagiwara M et al (2020) Successful hepatic resection for recurrent hepatocellular carcinoma after lenvatinib treatment: a case report. World J Hepatol 12:1349–1357. https:\u002F\u002Fdoi.org\u002F10.4254\u002Fwjh.v12.i12.1349\nTomonari T, Sato Y, Tanaka H et al (2020) Conversion therapy for unresectable hepatocellular carcinoma after lenvatinib: three case reports. Medicine (Baltimore) 99:e22782. https:\u002F\u002Fdoi.org\u002F10.1097\u002FMD.0000000000022782\nOhya Y, Hayashida S, Tsuji A et al (2020) Conversion hepatectomy for advanced hepatocellular carcinoma after right portal vein transection and lenvatinib therapy. Surg Case Rep 6:318. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs40792-020-01078-3\nMatsuki R, Kawai K, Suzuki Y et al (2020) Pathological complete response in conversion hepatectomy induced by lenvatinib for advanced hepatocellular carcinoma. Liver Cancer 9:358–360. https:\u002F\u002Fdoi.org\u002F10.1159\u002F000506202\nSato N, Beppu T, Kinoshita K et al (2019) Conversion hepatectomy for huge hepatocellular carcinoma with arterioportal shunt after chemoembolization and lenvatinib therapy. Anticancer Res 39:5695–5701. https:\u002F\u002Fdoi.org\u002F10.21873\u002Fanticanres.13768\nTakahashi A, Moriguchi M, Seko Y et al (2019) Impact of relative dose intensity of early-phase lenvatinib treatment on therapeutic response in hepatocellular carcinoma. Anticancer Res 39:5149–5156. https:\u002F\u002Fdoi.org\u002F10.21873\u002Fanticanres.13710\nSchlumberger M, Tahara M, Wirth LJ et al (2015) Lenvatinib versus placebo in radioiodine-refractory thyroid cancer. N Engl J Med 372:621–630. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMoa1406470\nLiu SQ, Zhang XJ, Xue Y et al (2021) A case of lenvatinib therapy-induced unilateral interstitial pneumonia and cavity formation in advanced liver cancer (in Chinese). Zhonghua Gan Zang Bing Za Zhi 29:1109–1110. https:\u002F\u002Fdoi.org\u002F10.3760\u002Fcma.j.cn501113-20201208-00646\nKotani K, Enomoto M, Okada M et al (2019) Interstitial pneumonia suspected during regorafenib administration and exacerbated by subsequent therapy with lenvatinib for unresectable hepatocellular carcinoma. Clin J Gastroenterol 12:355–360. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs12328-019-00983-x\nImakura T, Sato S, Tomonari T et al (2022) Lenvatinib-induced interstitial pneumonia in a patient with hepatocellular carcinoma. Intern Med 61:1211–1217. https:\u002F\u002Fdoi.org\u002F10.2169\u002Finternalmedicine.7300-21\nKimura-Tsuchiya R, Sasaki E, Nakamura I et al (2018) A case of squamous cell carcinoma of unknown primary that responded to the multi-tyrosine kinase inhibitor lenvatinib. Case Rep Oncol 11:75–80. https:\u002F\u002Fdoi.org\u002F10.1159\u002F000486569\nZheng H, Pomyen Y, Hernandez MO et al (2018) Single-cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma. Hepatology 68:127–140. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fhep.29778\nAl-Batran S-E, Hartmann JT, Heidel F et al (2007) Focal progression in patients with gastrointestinal stromal tumors after initial response to imatinib mesylate: a three-center-based study of 38 patients. Gastric Cancer 10:145–152. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs10120-007-0425-8\nKobayashi S, Boggon TJ, Dayaram T et al (2005) EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 352:786–792. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMoa044238\nJackman DM, Holmes AJ, Lindeman N et al (2006) Response and resistance in a non-small-cell lung cancer patient with an epidermal growth factor receptor mutation and leptomeningeal metastases treated with high-dose gefitinib. J Clin Oncol 24:4517–4520. https:\u002F\u002Fdoi.org\u002F10.1200\u002FJCO.2006.06.6126\nShindoh J, Kawamura Y, Kobayashi Y et al (2021) Prognostic Impact of Surgical Intervention After Lenvatinib Treatment for Advanced Hepatocellular Carcinoma. 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