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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":573,"VI":574},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":576},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[580],{"id":581,"createTime":20,"updateTime":20,"relativeEntities":582,"slug":20,"properties":583,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":593,"parentIds":594,"statistic":20},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":584,"address":587,"country":590,"abbreviation":591},{"EN":585,"VI":586},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":588,"VI":589},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":109},{"VOID":592},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":21,"impactFactorByYear":598,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":600,"totalPublicationByYear":601,"totalCitation":606,"totalCitationByYear":607,"totalCitationPerPublication":196,"totalCitationPerPublicationByYear":609,"hindexLast5Year":135,"hindex":135},{"2022":599,"2023":199,"2024":194},0.01,1556,{"2020":137,"2021":602,"2022":603,"2023":604,"2024":605,"2025":210},57,306,801,358,161,{"2021":233,"2022":366,"2023":608},99,{"2021":610,"2022":404,"2023":192},0.23,{"impactFactor":20,"impactFactorByYear":20,"i10Index":92,"i10IndexLast5Year":92,"totalPublication":612,"totalPublicationByYear":613,"totalCitation":612,"totalCitationByYear":614,"totalCitationPerPublication":91,"totalCitationPerPublicationByYear":617,"hindexLast5Year":93,"hindex":93},476,{"0":291,"2019":92,"2021":226,"2022":545,"2023":537,"2024":443,"2025":93,"2026":138},{"2021":132,"2022":92,"2023":248,"2024":615,"2025":446,"2026":616},136,83,{"2021":193,"2022":599,"2023":618,"2024":214,"2025":619,"2026":620},0.62,25.43,13.83,{"id":622,"createTime":623,"updateTime":468,"relativeEntities":624,"slug":625,"properties":626,"entityType":18,"verifyStatus":119,"verifyTime":20,"verifyNote":20,"languages":638,"translateLanguages":20,"viewCount":220,"subjectFields":639,"manageAffiliations":640,"indexDatabases":641,"url":642,"thumbnailPath":643,"statistic":644,"gsStatistic":680,"type":96,"analyzePriority":20},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":627,"issn":628,"title":630,"introduce":633,"gsId":636},{"VOID":109},{"VOID":629},"25252445",{"EN":631,"VI":632},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":634,"VI":635},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. Since then, the journal has grown in quality, size and scope and now comprises a dozen of serials spanning academic research. 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Although, the main text structure may vary based on the review subtopics, the articles should be formatted according to suitable Templates as research articles.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"\\n\"}]}","{\"ops\":[{\"insert\":\"Tạp chí Khoa học Trường ĐHSP Hà Nội 2 nhằm mục đích cung cấp một nền tảng liên ngành của sự phổ biến những tiến bộ của khoa học và công nghệ. Tạp chí xuất bản các bài báo gốc có giá trị khoa học hoặc công nghệ trong tất cả các lĩnh vực khoa học tự nhiên, xã hội hoặc giáo dục.\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Chuyên san Khoa học tự nhiên và công nghệ:\"},{\"insert\":\" Là các bài báo mô tả những phát hiện có giá trị trong vật lý, toán học, hóa học, sinh học; giải quyết các vấn đề kỹ thuật hoặc công nghệ.\"},{\"attributes\":{\"list\":\"bullet\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Chuyên san Khoa học Xã hội và Nhân văn:\"},{\"insert\":\" là các bài báo xuất bản chất lượng cao trong các lĩnh vực khác nhau của khoa học xã hội và nghiên cứu phát triển con người.\"},{\"attributes\":{\"list\":\"bullet\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Chuyên san Khoa học giáo dục:\"},{\"insert\":\" là các bài báo xuất bản trong lĩnh vực khoa học giáo dục và các ứng dụng của tiến bộ vào giáo dục để cải thiện và nâng cao giáo dục khoa học ở tất cả các cấp.\"},{\"attributes\":{\"list\":\"bullet\"},\"insert\":\"\\n\"},{\"insert\":\"Tạp chí trường ĐHSP Hà Nội 2 xuất bản được phản biện kín, xét duyệt bởi ít nhất 02 chuyên gia, và được đánh giá, chọn lựa từ ban biên tập và Tổng biên tập.\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Các loại bài báo\"},{\"insert\":\":\\nBài báo nghiên cứu:\"},{\"attributes\":{\"list\":\"ordered\"},\"insert\":\"\\n\"},{\"insert\":\"Báo cáo học thuật về nghiên cứu ban đầu chưa từng được xuất bản ở bất kỳ nơi nào, hay bằng bất kỳ ngôn ngữ nào khác. Bản thảo thích hợp, nên chứa các phần sau theo thứ tự: Tiêu đề, Tác giả, Liên kết tác giả, Địa chỉ email của tác giả tương ứng, Tóm tắt, Từ khóa, Danh pháp (nếu có), Giới thiệu, Thử nghiệm, Lý thuyết, Kết quả và thảo luận, Kết luận, Xung đột quan tâm, Lời cảm ơn (nếu có), Tài liệu tham khảo, Phụ lục (nếu có). Bản xuất bản trước phải được định dạng theo Mẫu (phiên bản MS-Word).\\n2. Bài báo tổng quan:\\nNgoài các bài phê bình được mời, các bài phê bình tài liệu, bài phê bình có hệ thống và bài phê bình sẽ được chấp nhận để xem xét. Bản thảo cần được soạn thảo và sắp xếp theo trình tự yêu cầu: Tên sách, Tên tác giả, Liên kết, Địa chỉ email, Tóm tắt, Từ khóa, Nội dung chính, Kết luận, Xung đột lợi ích, Lời cảm ơn (nếu có), Tài liệu tham khảo. Mặc dù, cấu trúc văn bản chính có thể thay đổi dựa trên các chủ đề phụ của bài đánh giá, các bài báo nên được định dạng theo các Mẫu phù hợp như các bài báo nghiên cứu.\\n\"}]}",{"VOID":812},"YPoBvsIAAAAJ",[],[],[],"https:\u002F\u002Fsj.hpu2.edu.vn\u002Findex.php\u002Fjournal","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F954132b5-ca74-461c-b819-45ad6e49a404\u002F2790ef1d0a7d7a40a504c2fc1647f670.jpg",{"impactFactor":21,"impactFactorByYear":819,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":415,"totalPublicationByYear":821,"totalCitation":221,"totalCitationByYear":822,"totalCitationPerPublication":610,"totalCitationPerPublicationByYear":823,"hindexLast5Year":92,"hindex":92},{"2024":820},0.17,{"2022":223,"2023":364,"2024":229},{"2022":443,"2023":213,"2024":92},{"2022":256,"2023":310,"2024":252},{"impactFactor":20,"impactFactorByYear":20,"i10Index":135,"i10IndexLast5Year":135,"totalPublication":416,"totalPublicationByYear":825,"totalCitation":241,"totalCitationByYear":826,"totalCitationPerPublication":827,"totalCitationPerPublicationByYear":828,"hindexLast5Year":136,"hindex":136},{"0":92,"2022":221,"2023":223,"2024":157,"2025":232},{"2023":136,"2024":223,"2025":287,"2026":364},1.22,{"2023":201,"2024":426,"2025":829},4.56,{"id":831,"createTime":832,"updateTime":833,"relativeEntities":834,"slug":835,"properties":836,"entityType":18,"verifyStatus":119,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":157,"subjectFields":848,"manageAffiliations":849,"indexDatabases":857,"url":897,"thumbnailPath":20,"statistic":898,"gsStatistic":930,"type":96,"analyzePriority":20},"21ccdb34-414d-420f-8a60-a592a2fa848e","2023-05-29T10:42:53.358+00:00","2026-08-27T01:57:29.560+00:00",[],"Vietnam-Journal-of-Earth-Sciences",{"country":837,"eissn":838,"issn":840,"title":842,"introduce":844,"gsId":846},{"VOID":109},{"VOID":839},"26159783",{"VOID":841},"08667187",{"EN":843},"Vietnam Journal of Earth Sciences",{"EN":845},"Science of the Earth, formerly Vietnam Journal of Earth Sciences, is a peer-reviewed journal to publish high-quality articles on the entire range of earth sciences and the environment, focused on the Asia Pacific region and their correlations and connections to the globe. The journal publishes fundamental and applied research in earth sciences and the environment, including geology, geophysics, geography, soil science, hydrology, meteorology, oceanography, petroleum, geohazards, environmental sciences, environmental engineering, sustainable development, geoinformatics, geodesy, GIS, and remote sensing.",{"VOID":847},"5htfr3YAAAAJ",[],[850],{"id":161,"createTime":20,"updateTime":20,"relativeEntities":851,"slug":20,"properties":852,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":170,"parentIds":856,"statistic":20},[],{"title":853,"country":854,"abbreviation":855},{"EN":165,"VI":166},{"VOID":109},{"VOID":169},[],[858,870,881],{"id":859,"indexDatabase":860,"url":865,"indexYears":866,"academicFieldIds":867,"indexDatabaseRanking":869},"6ace2085-a177-4a27-b309-8813b832111e",{"id":54,"createTime":20,"updateTime":20,"relativeEntities":861,"label":862,"description":863,"key":60,"publicationTags":864,"standard":20},[],{"EN":57,"VI":57},{"EN":57,"VI":59},[62],"https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F21101039869","2018-2024",[868],"1689391c-5702-4349-aaa7-d720ee4321fc","NONE",{"id":871,"indexDatabase":872,"url":877,"indexYears":878,"academicFieldIds":879,"indexDatabaseRanking":20},"dadb15a8-ee22-41c2-a287-49e969d9a998",{"id":176,"createTime":20,"updateTime":20,"relativeEntities":873,"label":874,"description":875,"key":182,"publicationTags":876,"standard":20},[],{"EN":179,"VI":179},{"EN":181,"VI":181},[184],"https:\u002F\u002Fasean-cites.org\u002Fjournal_info?jid=10629","2016-2022",[880],"e04f14cf-280b-4aa8-b711-b77ddd79cbaf",{"id":882,"indexDatabase":883,"url":894,"indexYears":20,"academicFieldIds":895,"indexDatabaseRanking":20},"06f278ee-37b9-41eb-a9b0-3d2d77fa502b",{"id":884,"createTime":20,"updateTime":20,"relativeEntities":885,"label":886,"description":888,"key":891,"publicationTags":892,"standard":20},"88bab0f7-443b-476c-a72a-7fa5222da393",[],{"EN":887,"VI":887},"ISI\u002FESCI  - 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We used multi−parametric flow cytometry, dimensionality reduction, unsupervised clustering, and self-organizing maps (SOM) to identify novel γδ T cell naïve\u002Fmemory subsets chiefly defined by CD161 expression levels, a surface membrane receptor that can be activating or suppressive. We used middle-to-old age individuals given immune blockade is commonly used in this population. Whilst most Vδ1+subset cells exhibited a terminal differentiation phenotype, Vδ1− subset cells showed an early memory phenotype. Dimensionality reduction revealed eight γδ T cell clusters chiefly diverging through CD161 expression with CD4 and CD8 expression limited to specific subpopulations. Comparison of matched healthy elderly individuals to bronchiectasis patients revealed elevated Vδ1+ terminally differentiated effector memory cells in patients potentially linking this population with chronic proinflammatory disease.",{"EN":959},"CD161 expression defines new human γδ T cell subsets",{"VOID":961},"Caccamo N. Sex-specific phenotypical and functional differences in peripheral human V 9\u002FV 2 T cells. J Leukoc Biol. 2006;79(4):663–6. https:\u002F\u002Fdoi.org\u002F10.1189\u002Fjlb.1105640.\nArstila TP, Lassila O. Androgen-induced expression of the peripheral blood gamma delta T cell population in the chicken. J Immunol (Baltimore, Md : 1950). 1993;151(12):6627–33.\nHein WR, Mackay CR. Prominence of γδ T cells in the ruminant immune system. Immunol Today. 1991;12(1):30–4. https:\u002F\u002Fdoi.org\u002F10.1016\u002F0167-5699(91)90109-7.\nDeusch K, Lüling F, Reich K, Classen M, Wagner H, Pfeffer K. 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Front Immunol. 2018;9:752. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffimmu.2018.00752.\nLukas Yani S, Keller M, Melzer FL, Weinberger B, Pangrazzi L, Sopper S, et al. CD8+HLADR+ regulatory T cells change with aging: they increase in number, but lose checkpoint inhibitory molecules and suppressive function. Front Immunol. 2018;9:1201. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffimmu.2018.01201.\nKedzierska K, Koutsakos M. The ABC of major histocompatibility complexes and T cell receptors in health and disease. Viral Immunol. 2020;33(3):160–78. https:\u002F\u002Fdoi.org\u002F10.1089\u002Fvim.2019.0184.\nVasudev A, Tan Tze Ying C, Ayyadhury S, Joo Puan K, Kumar Andiappan A, Shwe Zin Nyunt M, et al. γ\u002Fδ T cell subsets in human aging using the classical α\u002Fβ T cell model. J Leukoc Biol. 2014;96(4):647–55. https:\u002F\u002Fdoi.org\u002F10.1189\u002Fjlb.5A1213-650RR.\nGray JI, Westerhof LM, MacLeod MKL. The roles of resident, central and effector memory CD4 T-cells in protective immunity following infection or vaccination. 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They are some of the oldest members of our societies and survivors of their generation and may help us understand how to age not only longer, but better. The Belfast Longevity Group enlisted the help of 500 community-living, mobile, mentally competent, 'elite' nonagenarians, as part of an ongoing study of ageing. We assessed some immunological, cardiovascular, nutritional and genetic factors and some aspects of their interaction in this group of 'oldest old'. Here we present some of the evidence related to genetic and nutritional factors which seem to be important for good quality ageing in nonagenarians from the B elfast E lderly L ongitudinal F ree-living A geing ST udy (BELFAST).",{"EN":1280},"BELFAST nonagenarians: nature or nurture? Immunological, cardiovascular and genetic factors",{"VOID":1282},"Rea IM, McMaster D, Woodside JV, Young IS, Archbold GPR, Linton T, Lennox S, McNulty H, Harmon DL, Whitehead AS: Community living nonagenarians in Northern Ireland have lower plasma homocysteine but similar methylenetetrahydrofolate reductase thermolabile genotype prevalence compared to 70-89 year old subjects. Atherosclerosis. 2000, 149: 207-214. 10.1016\u002FS0021-9150(99)00417-7.\nRea IM, Myint PK, Mueller H, Murphy A, Archbold GP, McNulty H, Patterson CC: Nature or nurture; BMI and blood pressure at 90. Findings from the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST). Age (Dordr). 31 (4): 261-267. 10.1007\u002Fs11357-009-9096-1.\nFolstein MF, Folstein SE, McHugh PR: \"Mini-mental state\". A practical method for grading the cognitive state of patients for the clinician\". Psychiatr Res. 1975, 3: 189-198.\nRea IM, Gillen S, Clarke E: Anthropometric measurements from a cross-sectional survey of community dwelling subjects aged over 90 years of age. Eur J Clin Nutr. 1997, 51: 102-106. 10.1038\u002Fsj.ejcn.1600370.\nRea IM: Age and Sex changes in Neutrophil Function. Ageing; Immunology and Infectious Disease. 1988, 1: 121-130.\nWenisch C, Patruta S, Daxböck F, Krause R, Hörl W: Effect of age on human neutrophil function. J Leukoc Biol. 2000, 67: 40-45.\nAlonso-Fernández P, Puerto M, Maté I, Ribera JM, de la Fuente M: Neutrophils of centenarians show function levels similar to those of young adults. J Am Geriatr Soc. 2008, 56: 2244-2251. 10.1111\u002Fj.1532-5415.2008.02018.x.\nPanda A, Arjona A, Sapey E, Bai F, Fikrig E, Montgomery RR, Lord JM, Shaw AC: Human innate immunosenescence: causes and consequences for immunity in old age. Trends Immunol. 2009, 30: 325-333. 10.1016\u002Fj.it.2009.05.004.\nArmstrong ME, Alexander HD, Ritchie JL: Age-related alterations in basal expression and in vitro, tumour necrosis factor alpha mediated, upregulation of CD11b. Gerontology. 2001, 47: 180-185. 10.1159\u002F000052795.\nNiwa Y, Kasama T, Miyachi Y, Kanoh T: Neutrophil chemotaxis, phagocytosis and parameters of reactive oxygen species in human aging:-Neutrophils of centenarians show function levels similar to those of young adults. Life Sci. 1989, 44: 1655-1664. 10.1016\u002F0024-3205(89)90482-7.\nMocchegiani E, Giacconi R, Cipriano C, Malavolta M: NK and NKT Cells in Aging and Longevity: Role of Zinc and Metallothioneins. J Clin Immunol. 2009, 29 (Sp I): 416-425. 10.1007\u002Fs10875-009-9298-4.\nKaszubowska L, Dettlaff-Pokora A, Hak L, Szarynska M, Ryba M, Mysliwska J, Mysliwski A: Successful ageing of nonagenarians is related to the sensitivity of NK cells to activation. J Physiol Pharmacol. 2008, 59 (Suppl 9): 187-199.\nDubey DP, Husain Z, Levitan E, Zurakowski D, Mirza N, Younes S, Coronell C, Yunis D, Yunis EJ: The MHC influences NK and NKT cell functions associated with immune abnormalities and lifespan. Mech Ageing Dev. 2000, 113: 117-134. 10.1016\u002FS0047-6374(99)00102-5.\nMiyaji C, Watanabe H, Minagawa M, Toma H, Kawamura T, Nohara Y, Nozaki H, Sato Y, Abo T: Numerical and functional characteristics of lymphocyte subsets in centenarians. J Clin Immunol. 1997, 5: 420-429. 10.1023\u002FA:1027324626199.\nSansoni P, Cossarizza A, Brianti V, Fagnoni F, Snelli G, Monti D, Marcato A, Passeri G, Ortolani C, Forti E: Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians. Blood. 1993, 82: 2767-2773.\nMcNerlan SE, Rea IM, Alexander HD, Morris TC: Changes in natural killer cells, the CD57CD8 subset, and related cytokines in healthy aging. J Clin Immunol. 1998, 18: 31-38. 10.1023\u002FA:1023283719877.\nPeralbo E, Alonso C, Solana R: Invariant NKT and NKT-like lymphocytes: two different T cell subsets that are differentially affected by ageing. Exp Gerontol. 2007, 42: 703-708. 10.1016\u002Fj.exger.2007.05.002. Epub 2007 May 21.\nMariani E, Ravaglia G, Forti P, Meneghetti A, Tarozzi A, Maioli F, Boschi F, Facchini A: Nutrition and NK cell mediated immunity in centenarians. Immunology Letters. 1997, 56 (Part 2): 383-\nMaxwell LD, Ross OA, Curran MD, Rea IM, Middleton D: Investigation of KIR diversity in immunosenescence and longevity within the Irish population. Exp Gerontol. 2004, 39: 1223-1232. 10.1016\u002Fj.exger.2004.05.003.\nRea IM, Maxwell LD, Ross OA, McNerlan SE, Alexander HD: Pro-inflammatory and anti-inflammatory cytokines track with KIR haplotypes A and B in octo\u002Fnonagenarian subjects. Clin Immunol. 2005, 115 (Suppl 1): S202-\nFranceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G: Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci. 2000, 908: 244-254. 10.1111\u002Fj.1749-6632.2000.tb06651.x.\nRea IM, Stewart M, Campbell P, Alexander HD, Crockard AD, Morris TCM: Changes in lymphocyte subsets, interleukin 2, and soluble interleukin 2 receptor in old and very old age. Gerontology. 1996, 42: 69-78. 10.1159\u002F000213775.\nMcNerlan SE, Alexander HD, Rea IM: Age-related reference intervals for lymphocyte subsets in whole blood of healthy individuals. Scand J Clin Lab Invest. 1999, 59: 89-92. 10.1080\u002F00365519950185805.\nCzesnikiewicz-Guzik M, Lee WW, Cui D, Hiruma Y, Lamar DL, Yang ZZ, Ouslander JG, Weyand CM, Goronzy JJ: T cell subset-specific susceptibility to aging. 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PNAS. 2008, 105 (44): 17046-17049. 10.1073\u002Fpnas.0806560105.",{"VOID":1284},"10.1186\u002F1742-4933-7-6","https:\u002F\u002Fimmunityageing.biomedcentral.com\u002Farticles\u002F10.1186\u002F1742-4933-7-6",[1287],{"id":1288,"sortIndex":21,"researcher":20,"roles":1289,"affiliations":1290,"properties":1299,"displayName":1301,"givenName":20,"familyName":20},"eae80a08-c05c-4855-a07d-3796d23e176b",[971],[1291],{"id":1292,"sortIndex":21,"affiliation":1293,"properties":20},"7c645f08-0e2d-4775-8f0b-0208a5f3935e",{"id":1292,"createTime":20,"updateTime":20,"relativeEntities":1294,"slug":20,"properties":1295,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1298,"statistic":20},[],{"title":1296},{"VI":1297},"Department of Geriatric Medicine, School of Medicine, Dentistry and Biomedical Science, Queens University Belfast, Whitla Medical Building, Belfast, Northern Ireland",[],{"title":1300},{"VI":1301},"I M Rea",{"url":1285,"publisher":1303,"properties":1348},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1304,"slug":10,"properties":1305,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1308,"manageAffiliations":1317,"indexDatabases":1328,"url":20,"thumbnailPath":20,"statistic":1343,"gsStatistic":20,"type":96,"analyzePriority":20},[],{"issn":1306,"title":1307},{"VOID":13},{"EN":15},[1309,1313],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":1310,"label":1311,"description":1312,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},{"id":30,"createTime":20,"updateTime":20,"relativeEntities":1314,"label":1315,"description":1316,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":33},{},[1318,1323],{"id":37,"createTime":20,"updateTime":20,"relativeEntities":1319,"slug":20,"properties":1320,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1322,"statistic":20},[],{"title":1321},{"EN":41},[],{"id":44,"createTime":20,"updateTime":20,"relativeEntities":1324,"slug":20,"properties":1325,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1327,"statistic":20},[],{"title":1326},{"EN":48},[],[1329,1336],{"id":52,"indexDatabase":1330,"url":63,"indexYears":64,"academicFieldIds":1335,"indexDatabaseRanking":68},{"id":54,"createTime":20,"updateTime":20,"relativeEntities":1331,"label":1332,"description":1333,"key":60,"publicationTags":1334,"standard":20},[],{"EN":57,"VI":57},{"EN":57,"VI":59},[62],[66,67],{"id":70,"indexDatabase":1337,"url":83,"indexYears":20,"academicFieldIds":1342,"indexDatabaseRanking":20},{"id":72,"createTime":20,"updateTime":20,"relativeEntities":1338,"label":1339,"description":1340,"key":79,"publicationTags":1341,"standard":20},[],{"EN":75,"VI":75},{"EN":77,"VI":78},[81,82],[85,86],{"impactFactor":21,"impactFactorByYear":1344,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":89,"totalPublicationByYear":1345,"totalCitation":21,"totalCitationByYear":1346,"totalCitationPerPublication":21,"totalCitationPerPublicationByYear":1347,"hindexLast5Year":21,"hindex":21},{},{"2005":91,"2010":91,"2014":92,"2020":92,"2022":92,"2023":91,"2024":93},{},{},{"pages":1349,"volume":1351},{"VOID":1350},"1-9",{"VOID":1352},"7","2010-05-27",2010,[68,81],{"id":1357,"createTime":1358,"updateTime":1359,"relativeEntities":1360,"slug":1361,"properties":1362,"entityType":964,"verifyStatus":119,"verifyTime":1359,"verifyNote":965,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":1371,"fullTextUrl":20,"authors":1372,"publicationType":1214,"publisherRelationship":1506,"citationCount":20,"citationInfo":20,"publishDate":1557,"publishYear":1558,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":1559,"openAccess":20,"references":20,"isForceReanalyzing":1269},"034f070d-7d2e-4c78-af99-6f8fba45d494","2024-01-04T11:38:16.490+00:00","2025-02-17T11:07:57.227+00:00",[],"Temporal-trends-sex-differences-and-age-related-disease-influence-in-Neutrophil-Lymphocyte-count-and-Neutrophil-to-Lymphocyte-ratio-results-from-InCHIANTI-follow-up-study",{"abstract":1363,"title":1365,"references":1367,"doi":1369},{"EN":1364},"Neutrophils and lymphocytes represent the larger percentage of all white blood cells, they vary with age, with a progressive increase of the ratio in the first years of life, and then tend to remain at similar levels in steady state condition during adult age. Neutrophils to lymphocytes-ratio (NL-ratio) was proposed as an effective and low-cost marker to monitor and predict the evolution of several clinical conditions. The main objective of the study is to analyze its temporal trend variation, over twenty years’ follow-up, according to age, sex, and main clinical diagnosis, in a large representative Italian population. The InCHIANTI study enrolled representative samples from the registry list of two towns in Tuscany, Italy. Baseline data were collected in 1998, and last follow-up visits were made in 2015-18. 1343 out of the 1453 participants enrolled were included, and consented to donate a blood sample. All subjects were assessed and followed for life-style, clinical condition, physical performance, and underwent an instrumental diagnostic session. The NL-ratio showed a statistically significant interaction between birth-cohort and time of the study (p-value = 0.005). A gender dimorphism was recognized in the neutrophils absolute count and in the NL-ratio. Moreover, in female participants only, those who reported CHF had lower neutrophil-count and NL-ratio; whereas an increase in creatinine clearance was directly associated with NL-ratio. In male subjects, an increase of BMI was inversely associated with both NL-ratio and neutrophils-count during the follow-up; a similar association but in the opposite direction was observed in female participants. NL-ratio is a more reliable predictor of healthy aging than absolute lymphocytes and\u002For neutrophils counts. It is associated with the changes induced by disease, lifestyle, and environmental challenges in the immune system. NL-ratio confirms the gender dimorphism in the occurrence of inflammation-driven diseases, thus providing additional evidence for the necessity of tailored sex-specific measures to prevent and treat such diseases.",{"EN":1366},"Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study",{"VOID":1368},"Martínez de Toda I, Maté I, Vida C, Cruces J, De la Fuente M. Immune function parameters as markers of biological age and predictors of longevity. Aging. 2016;8:3110–9. https:\u002F\u002Fdoi.org\u002F10.18632\u002Faging.101116.\nFurman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25:1822–32. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41591-019-0675-0.\nFranceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, et al. 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Ferrucci",{"url":1371,"publisher":1507,"properties":1552},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1508,"slug":10,"properties":1509,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1512,"manageAffiliations":1521,"indexDatabases":1532,"url":20,"thumbnailPath":20,"statistic":1547,"gsStatistic":20,"type":96,"analyzePriority":20},[],{"issn":1510,"title":1511},{"VOID":13},{"EN":15},[1513,1517],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":1514,"label":1515,"description":1516,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},{"id":30,"createTime":20,"updateTime":20,"relativeEntities":1518,"label":1519,"description":1520,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":33},{},[1522,1527],{"id":37,"createTime":20,"updateTime":20,"relativeEntities":1523,"slug":20,"properties":1524,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1526,"statistic":20},[],{"title":1525},{"EN":41},[],{"id":44,"createTime":20,"updateTime":20,"relativeEntities":1528,"slug":20,"properties":1529,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1531,"statistic":20},[],{"title":1530},{"EN":48},[],[1533,1540],{"id":52,"indexDatabase":1534,"url":63,"indexYears":64,"academicFieldIds":1539,"indexDatabaseRanking":68},{"id":54,"createTime":20,"updateTime":20,"relativeEntities":1535,"label":1536,"description":1537,"key":60,"publicationTags":1538,"standard":20},[],{"EN":57,"VI":57},{"EN":57,"VI":59},[62],[66,67],{"id":70,"indexDatabase":1541,"url":83,"indexYears":20,"academicFieldIds":1546,"indexDatabaseRanking":20},{"id":72,"createTime":20,"updateTime":20,"relativeEntities":1542,"label":1543,"description":1544,"key":79,"publicationTags":1545,"standard":20},[],{"EN":75,"VI":75},{"EN":77,"VI":78},[81,82],[85,86],{"impactFactor":21,"impactFactorByYear":1548,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":89,"totalPublicationByYear":1549,"totalCitation":21,"totalCitationByYear":1550,"totalCitationPerPublication":21,"totalCitationPerPublicationByYear":1551,"hindexLast5Year":21,"hindex":21},{},{"2005":91,"2010":91,"2014":92,"2020":92,"2022":92,"2023":91,"2024":93},{},{},{"pages":1553,"volume":1555},{"VOID":1554},"1-10",{"VOID":1556},"20","2023-09-04",2023,[68,81],{"id":1561,"createTime":1562,"updateTime":1562,"relativeEntities":1563,"slug":1564,"properties":1565,"entityType":964,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":1574,"fullTextUrl":20,"authors":1575,"publicationType":1214,"publisherRelationship":1652,"citationCount":20,"citationInfo":20,"publishDate":1703,"publishYear":1704,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":1705,"openAccess":20,"references":20,"isForceReanalyzing":1269},"04a9ea9d-3b91-4abd-b6aa-668a2535a34a","2023-11-27T03:28:31.786+00:00",[],"Age-related-changes-in-arthritis-susceptibility-and-severity-in-a-murine-model-of-rheumatoid-arthritis",{"abstract":1566,"title":1568,"references":1570,"doi":1572},{"EN":1567},"Rheumatoid arthritis (RA) most often begins in females in the fourth-fifth decade of their life, suggesting that the aging of the immune system (immunosenescence) has a major role in this disease. Therefore, in the present study, we sought to investigate the effect of age on arthritis susceptibility in BALB\u002Fc mice using the proteoglycan (PG)-induced arthritis (PGIA) model of RA. We have found that young, 1-month-old female BALB\u002Fc mice are resistant to the induction of PGIA, but with aging they become susceptible. PG-induced T cell responses decline with age, whereas there is a shift toward Th1 cytokines. An age-dependent decrease in T cell number is associated with an increased ratio of the memory phenotype, and lower CD28 expression. Antigen-presenting cells shifted from macrophages and myeloid dendritic cells in young mice toward B cells in older mice. The regulatory\u002Factivated T cell ratio decreases in older mice after PG injections indicating impaired regulation of the immune response. We conclude that immunosenescence could alter arthritis susceptibility in a very complex manner including both adaptive and innate immunities, and it cannot be determined by a single trait. Cumulative alterations in immunoregulatory functions closely resemble human disease, which makes this systemic autoimmune arthritis model of RA even more valuable.",{"EN":1569},"Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritis",{"VOID":1571},"Ginaldi L, De Martinis M, D'Ostilio A, Marini L, Loreto MF, Quaglino D: The immune system in the elderly: III. Innate immunity. Immunol Res. 1999, 20: 117-126. 10.1007\u002FBF02786468.\nHakim FT, Gress RE: Immunosenescence: deficits in adaptive immunity in the elderly. Tissue Antigens. 2007, 70: 179-189. 10.1111\u002Fj.1399-0039.2007.00891.x.\nGoronzy JJ, Lee WW, Weyand CM: Aging and T-cell diversity. Exp Gerontol. 2007, 42: 400-406. 10.1016\u002Fj.exger.2006.11.016.\nKoetz K, Bryl E, Spickschen K, O'Fallon WM, Goronzy JJ, Weyand CM: T cell homeostasis in patients with rheumatoid arthritis. Proc Natl Acad Sci USA. 2000, 97: 9203-9208. 10.1073\u002Fpnas.97.16.9203.\nThewissen M, Linsen L, Somers V, Geusens P, Raus J, Stinissen P: Premature immunosenescence in rheumatoid arthritis and multiple sclerosis patients. Ann N Y Acad Sci. 2005, 1051: 255-262. 10.1196\u002Fannals.1361.066.\nCzesnikiewicz-Guzik M, Lee WW, Cui D, Hiruma Y, Lamar DL, Yang ZZ, Ouslander JG, Weyand CM, Goronzy JJ: T cell subset-specific susceptibility to aging. Clin Immunol. 2008, 127: 107-118. 10.1016\u002Fj.clim.2007.12.002.\nPawelec G, Barnett Y, Forsey R, Frasca D, Globerson A, McLeod J, Caruso C, Franceschi C, Fulop T, Gupta S, Mariani E, Mocchegiani E: T cells and aging, January 2002 update. Front Biosci. 2002, 7: d1056-d1183.\nAspinall R, Andrew D: Thymic involution in aging. J Clin Immunol. 2000, 20: 250-256. 10.1023\u002FA:1006611518223.\nThewissen M, Stinissen P: New concepts on the pathogenesis of autoimmune diseases: a role for immune homeostasis, immunoregulation, and immunosenescence. Crit Rev Immunol. 2008, 28: 363-376.\nFujii H, Shao L, Colmegna I, Goronzy JJ, Weyand CM: Telomerase insufficiency in rheumatoid arthritis. Proc Natl Acad Sci USA. 2009, 106: 4360-4365. 10.1073\u002Fpnas.0811332106.\nPawelec G, Hirokawa K, Fulop T: Altered T cell signalling in ageing. Mech Ageing Dev. 2001, 122: 1613-1637. 10.1016\u002FS0047-6374(01)00290-1.\nThewissen M, Somers V, Hellings N, Fraussen J, Damoiseaux J, Stinissen P: CD4+CD28null T cells in autoimmune disease: pathogenic features and decreased susceptibility to immunoregulation. J Immunol. 2007, 179: 6514-6523.\nWarrington KJ, Vallejo AN, Weyand CM, Goronzy JJ: CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation. Blood. 2003, 101: 3543-3549. 10.1182\u002Fblood-2002-08-2574.\nGoronzy JJ, Weyand CM: Rheumatoid arthritis. Immunol Rev. 2005, 204: 55-73. 10.1111\u002Fj.0105-2896.2005.00245.x.\nHaynes L, Eaton SM, Burns EM, Randall TD, Swain SL: CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly. Proc Natl Acad Sci USA. 2003, 100: 15053-15058. 10.1073\u002Fpnas.2433717100.\nLee WW, Yang ZZ, Li G, Weyand CM, Goronzy JJ: Unchecked CD70 expression on T cells lowers threshold for T cell activation in rheumatoid arthritis. J Immunol. 2007, 179: 2609-2615.\nVallejo AN, Nestel AR, Schirmer M, Weyand CM, Goronzy JJ: Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene-specific nuclear factor binding activity. J Biol Chem. 1998, 273: 8119-8129. 10.1074\u002Fjbc.273.14.8119.\nJohnson SA, Cambier JC: Ageing, autoimmunity and arthritis: senescence of the B cell compartment – implications for humoral immunity. Arthritis Res Ther. 2004, 6: 131-139. 10.1186\u002Far1180.\nLeMaoult J, Szabo P, Weksler ME: Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development. Immunol Rev. 1997, 160: 115-126. 10.1111\u002Fj.1600-065X.1997.tb01032.x.\nGlant TT, Mikecz K, Arzoumanian A, Poole AR: Proteoglycan-induced arthritis in BALB\u002Fc mice. Clinical features and histopathology. Arthritis Rheum. 1987, 30: 201-212. 10.1002\u002Fart.1780300211.\nAggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL: Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem. 2003, 278: 1910-1914. 10.1074\u002Fjbc.M207577200.\nBuzas EI, Brennan FR, Mikecz K, Garzó M, Negroiu G, Holló K, Cs-Szabó G, Pintye É, Glant TT: A proteoglycan (aggrecan)-specific T cell hybridoma induces arthritis in BALB\u002Fc mice. J Immunol. 1995, 155: 2679-2687.\nGlant TT, Buzas EI, Finnegan A, Negroiu G, Cs-Szabó G, Mikecz K: Critical role of glycosaminoglycan side chains of cartilage proteoglycan (aggrecan) in antigen recognition and presentation. J Immunol. 1998, 160: 3812-3819.\nGlant TT, Finnegan A, Mikecz K: Proteoglycan-induced arthritis: immune regulation, cellular mechanisms and genetics. Crit Rev Immunol. 2003, 23: 199-250. 10.1615\u002FCritRevImmunol.v23.i3.20.\nGlant TT, Mikecz K: Proteoglycan aggrecan-induced arthritis. A murine autoimmune model of rheumatoid arthritis. Methods Mol Med. 2004, 102: 313-338.\nHanyecz A, Berlo SE, Szanto S, Broeren CPM, Mikecz K, Glant TT: Achievement of a synergistic adjuvant effect on arthritis induction by activation of innate immunity and forcing the immune response toward the Th1 phenotype. Arthritis Rheum. 2004, 50: 1665-1676. 10.1002\u002Fart.20180.\nFinnegan A, Mikecz K, Tao P, Glant TT: Proteoglycan (aggrecan)-induced arthritis in BALB\u002Fc mice is a Th1-type disease regulated by Th2 cytokines. J Immunol. 1999, 163: 5383-5390.\nBoldizsar F, Tarjanyi O, Nemeth P, Mikecz K, Glant TT: Th1\u002FTh17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB\u002Fc, but not in MHC-matched, arthritis-resistant DBA\u002F2 mice. Int Immunol. 2009\nBardos T, Mikecz K, Finnegan A, Zhang J, Glant TT: T and B cell recovery in arthritis adoptively transferred to SCID mice: Antigen-specific activation is required for restoration of autopathogenic CD4+ Th1 cells in a syngeneic system. J Immunol. 2002, 168: 6013-6021.\nCostantino CM, Baecher-Allan CM, Hafler DA: Human regulatory T cells and autoimmunity. Eur J Immunol. 2008, 38: 921-924. 10.1002\u002Feji.200738104.\nAlamanos Y, Drosos AA: Epidemiology of adult rheumatoid arthritis. Autoimmun Rev. 2005, 4: 130-136. 10.1016\u002Fj.autrev.2004.09.002.\nKelchtermans H, De Klerck B, Mitera T, Van Balen M, Bullens D, Billiau A, Leclercq G, Matthys P: Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-gamma. Arthritis Res Ther. 2005, 7: R402-R415. 10.1186\u002Far1500.\nMorgan ME, Witteveen HJ, Sutmuller RP, de Vries RR, Toes RE: CD25+ regulatory cells from HLA-DQ8 transgenic mice are capable of modulating collagen-induced arthritis. Hum Immunol. 2004, 65: 1319-1327. 10.1016\u002Fj.humimm.2004.06.011.\nMorgan ME, Sutmuller RP, Witteveen HJ, van Duivenvoorde LM, Zanelli E, Melief CJ, Snijders A, Offringa R, de Vries RR, Toes RE: CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis. Arthritis Rheum. 2003, 48: 1452-1460. 10.1002\u002Fart.11063.\nFrey O, Petrow PK, Gajda M, Siegmund K, Huehn J, Scheffold A, Hamann A, Radbruch A, Brauer R: The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells. Arthritis Res Ther. 2005, 7: R291-R301. 10.1186\u002Far1484.\nLoughry A, Fairchild S, Athanasou N, Edwards J, Hall FC: Inflammatory arthritis and dermatitis in thymectomized, CD25+ cell-depleted adult mice. Rheumatology (Oxford). 2005, 44: 299-308. 10.1093\u002Frheumatology\u002Fkeh477.\nHolló K, Glant TT, Garzó M, Finnegan A, Mikecz K, Buzas EI: Complex pattern of Th1 and Th2 activation with a preferential increase of autoreactive Th1 cells in BALB\u002Fc mice with proteoglycan (aggrecan)-induced arthritis. Clin Exp Immunol. 2000, 120: 167-173. 10.1046\u002Fj.1365-2249.2000.01174.x.\nFinnegan A, Grusby MJ, Kaplan CD, O'Neill SK, Eibel H, Koreny T, Czipri M, Mikecz K, Zhang J: IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms. J Immunol. 2002, 169: 3345-3352.\nDoodes PD, Cao Y, Hamel KM, Wang Y, Farkas B, Iwakura Y, Finnegan A: Development of proteoglycan-induced arthritis is independent of IL-17. J Immunol. 2008, 181: 329-337.\nJohnson SA, Rozzo SJ, Cambier JC: Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire. J Immunol. 2002, 168: 5014-5023.\nMikecz K, Glant TT, Poole AR: Immunity to cartilage proteoglycans in BALB\u002Fc mice with progressive polyarthritis and ankylosing spondylitis induced by injection of human cartilage proteoglycan. Arthritis Rheum. 1987, 30: 306-318. 10.1002\u002Fart.1780300310.\nDuncan DD, Swain SL: Role of antigen-presenting cells in the polarized development of helper T cell subsets: evidence for differential cytokine production by Th0 cells in response to antigen presentation by B cells and macrophages. Eur J Immunol. 1994, 24: 2506-2514. 10.1002\u002Feji.1830241037.\nGlant TT, Mikecz K, Poole AR: Monoclonal antibodies to different protein-related epitopes of human articular cartilage proteoglycans. Biochem J. 1986, 234: 31-41.\nDavis LS, Lipsky PE, Bottomly K: Measurement of human and murine interleukin 2 and interleukin 4. Current Protocols in Immunology. Edited by: Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W. 1995, N.Y.: John Wiley Sons, Inc, 63.1-6.3.13.\nBerlo SE, Guichelaar T, ten Brink CB, Van Kooten PJ, Hauet-Broere F, Ludanyi K, van Eden W, Broeren CP, Glant TT: Increased arthritis susceptibility in cartilage proteoglycan-specific T cell receptor-transgenic mice. Arthritis Rheum. 2006, 54: 2423-2433. 10.1002\u002Fart.22013.\nWells SM, Kantor AB, Stall AM: CD43 (S7) expression identifies peripheral B cell subsets. J Immunol. 1994, 153: 5503-5515.",{"VOID":1573},"10.1186\u002F1742-4933-6-8","https:\u002F\u002Fimmunityageing.biomedcentral.com\u002Farticles\u002F10.1186\u002F1742-4933-6-8",[1576,1591,1613,1626,1639],{"id":1577,"sortIndex":21,"researcher":20,"roles":1578,"affiliations":1579,"properties":1588,"displayName":1590,"givenName":20,"familyName":20},"2772c7a9-ed22-4cc4-a70f-aec4de05970f",[971],[1580],{"id":1581,"sortIndex":21,"affiliation":1582,"properties":20},"d55c7333-cfaf-46f8-b805-4e1b268087da",{"id":1581,"createTime":20,"updateTime":20,"relativeEntities":1583,"slug":20,"properties":1584,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1587,"statistic":20},[],{"title":1585},{"VI":1586},"Section of Molecular Medicine, Departments of Orthopedic Surgery, Biochemistry and Internal Medicine (Rheumatology), Chicago, USA",[],{"title":1589},{"VI":1590},"Oktavia 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Faculty of Medicine, University of Pecs, Hungary",[],{},{"title":1611},{"VI":1612},"Ferenc Boldizsar",{"id":1614,"sortIndex":92,"researcher":20,"roles":1615,"affiliations":1616,"properties":1623,"displayName":1625,"givenName":20,"familyName":20},"3882ffa5-10d4-46d4-bd46-48252906af98",[971],[1617],{"id":1602,"sortIndex":21,"affiliation":1618,"properties":20},{"id":1602,"createTime":20,"updateTime":20,"relativeEntities":1619,"slug":20,"properties":1620,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1622,"statistic":20},[],{"title":1621},{"VI":1607},[],{"title":1624},{"VI":1625},"Peter 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in patients with Alzheimer's disease (AD) is rapidly becoming a hot topic of modern geriatric and clinical gerontology. Current views see immunization with Aβ peptide, the amyloidogenic protein found in senile plaque of AD patient's brains, or the infusion of preformed antibody specific for human Aβ, as possible therapeutic approaches to improve the cognitive status in the disease. Animal models of the disease have provided positive results from both approaches. Thus, an initial clinical trial using immunization with human Aβ in AD patients was started, but then shortly halted because of an unusually high incidence (6%) of meningoencephalitis. A long and currently ongoing debate in the scientific community about the pro or contra of vaccination or passive immunization with Aβ in AD is thereafter started. Here, the authors would like to stress few points of concern regarding these approaches in clinical practice.",{"EN":1714},"Is immunotherapy an effective treatment for Alzheimer's disease?",{"VOID":1716},"Weksler ME: The immunotherapy of Alzheimer's disease. Immun Ageing. 2004,\nSchenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P: Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature. 1999, 400: 173-177. 10.1038\u002F22124.\nBard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Lieberburg I, Motter R, Nguyen M, Soriano F, Vasquez N, Weiss K, Welch B, Seubert P, Schenk D, Yednock : Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. T Nat Med. 2000, 6: 916-919. 10.1038\u002F78682.\nMorgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW: A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 2000, 408: 982-985. 10.1038\u002F35050116.\nAkiyama H, McGeer PL: Specificity of mechanisms for plaque removal after A beta immunotherapy for Alzheimer disease. Nat Med. 2004, 10: 117-118. 10.1038\u002Fnm0204-117.\nNicoll JA, Wilkinson D, Holmes C, Steart P, Markham H, Weller RO: Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med. 2003, 9: 448-425. 10.1038\u002Fnm840.\nNicoll JAR, Wilkinson D, Holmes C, Stear P, Markham H, Weller R: reply. Nat Med. 2004, 10: 118-119. 10.1038\u002Fnm0204-118.\nVasto S, Caruso C: IMMUNITY&AGEING: a new journal looking at ageing from an immunological point of view. Immun Ageing. 2004, 1: 1-10.1186\u002F1742-4933-1-1.",{"VOID":1718},"10.1186\u002F1742-4933-1-3","https:\u002F\u002Fimmunityageing.biomedcentral.com\u002Farticles\u002F10.1186\u002F1742-4933-1-3",[1721,1736],{"id":1722,"sortIndex":21,"researcher":20,"roles":1723,"affiliations":1724,"properties":1733,"displayName":1735,"givenName":20,"familyName":20},"e208bde1-fdfb-4dfc-a9b3-6deccb3be185",[971],[1725],{"id":1726,"sortIndex":21,"affiliation":1727,"properties":20},"3c9b4355-68c3-45f1-b091-9780ad728a85",{"id":1726,"createTime":20,"updateTime":20,"relativeEntities":1728,"slug":20,"properties":1729,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1732,"statistic":20},[],{"title":1730},{"VI":1731},"Dipartimento di Patologia Sperimentale, Università di Bologna, Bologna, Italy",[],{"title":1734},{"VI":1735},"Federico Licastro",{"id":1737,"sortIndex":91,"researcher":20,"roles":1738,"affiliations":1739,"properties":1748,"displayName":1750,"givenName":20,"familyName":20},"b5317518-99a5-4e36-997b-31337a15d9b4",[971],[1740],{"id":1741,"sortIndex":21,"affiliation":1742,"properties":20},"81919646-4fa4-452a-95ea-e5da69be1df9",{"id":1741,"createTime":20,"updateTime":20,"relativeEntities":1743,"slug":20,"properties":1744,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1747,"statistic":20},[],{"title":1745},{"VI":1746},"Gruppo di Studio sull’Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Palermo, Italy",[],{"title":1749},{"VI":1750},"Calogero Caruso",{"url":1719,"publisher":1752,"properties":1797},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1753,"slug":10,"properties":1754,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1757,"manageAffiliations":1766,"indexDatabases":1777,"url":20,"thumbnailPath":20,"statistic":1792,"gsStatistic":20,"type":96,"analyzePriority":20},[],{"issn":1755,"title":1756},{"VOID":13},{"EN":15},[1758,1762],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":1759,"label":1760,"description":1761,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},{"id":30,"createTime":20,"updateTime":20,"relativeEntities":1763,"label":1764,"description":1765,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":33},{},[1767,1772],{"id":37,"createTime":20,"updateTime":20,"relativeEntities":1768,"slug":20,"properties":1769,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1771,"statistic":20},[],{"title":1770},{"EN":41},[],{"id":44,"createTime":20,"updateTime":20,"relativeEntities":1773,"slug":20,"properties":1774,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1776,"statistic":20},[],{"title":1775},{"EN":48},[],[1778,1785],{"id":52,"indexDatabase":1779,"url":63,"indexYears":64,"academicFieldIds":1784,"indexDatabaseRanking":68},{"id":54,"createTime":20,"updateTime":20,"relativeEntities":1780,"label":1781,"description":1782,"key":60,"publicationTags":1783,"standard":20},[],{"EN":57,"VI":57},{"EN":57,"VI":59},[62],[66,67],{"id":70,"indexDatabase":1786,"url":83,"indexYears":20,"academicFieldIds":1791,"indexDatabaseRanking":20},{"id":72,"createTime":20,"updateTime":20,"relativeEntities":1787,"label":1788,"description":1789,"key":79,"publicationTags":1790,"standard":20},[],{"EN":75,"VI":75},{"EN":77,"VI":78},[81,82],[85,86],{"impactFactor":21,"impactFactorByYear":1793,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":89,"totalPublicationByYear":1794,"totalCitation":21,"totalCitationByYear":1795,"totalCitationPerPublication":21,"totalCitationPerPublicationByYear":1796,"hindexLast5Year":21,"hindex":21},{},{"2005":91,"2010":91,"2014":92,"2020":92,"2022":92,"2023":91,"2024":93},{},{},{"pages":1798,"volume":1800},{"VOID":1799},"1-2",{"VOID":1801},"1","2004-11-12",2004,[68,81],{"id":1806,"createTime":1807,"updateTime":1808,"relativeEntities":1809,"slug":1810,"properties":1811,"entityType":964,"verifyStatus":119,"verifyTime":1808,"verifyNote":965,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":1820,"fullTextUrl":20,"authors":1821,"publicationType":1214,"publisherRelationship":1959,"citationCount":20,"citationInfo":20,"publishDate":2010,"publishYear":2011,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":2012,"openAccess":20,"references":20,"isForceReanalyzing":1269},"05f3cd75-ee7f-4c7c-8706-aaafd8c045fa","2024-02-20T17:11:14.545+00:00","2024-12-11T21:08:14.255+00:00",[],"In-depth-immune-cellular-profiling-reveals-sex-specific-associations-with-frailty",{"abstract":1812,"title":1814,"references":1816,"doi":1818},{"EN":1813},"With advancing age, the composition of leukocyte subpopulations in peripheral blood is known to change, but how this change differs between men and women and how it relates to frailty is poorly understood. Our aim in this exploratory study was to investigate whether frailty is associated with changes in immune cell subpopulations and whether this differs between men and women. Therefore, we performed in-depth immune cellular profiling by enumerating a total of 37 subpopulations of T cells, B cells, NK cells, monocytes, and neutrophils in peripheral blood of 289 elderly people between 60-87 years of age. Associations between frailty and each immune cell subpopulation were tested separately in men and women and were adjusted for age and CMV serostatus. In addition, a random forest algorithm was used to predict a participant’s frailty score based on enumeration of immune cell subpopulations. In the association study, frailty was found to be associated with increased numbers of neutrophils in both men and in women. Frailer women, but not men, showed higher numbers of total and CD16- monocytes, and lower numbers of both CD56+ T cells and late differentiated CD4+ TemRA cells. The random forest algorithm confirmed all the findings of the association studies in men and women. In men, the predictive accuracy of the algorithm was too low (5.5%) to warrant additional conclusions on top of the ones derived from the association study. In women however, the predictive accuracy was higher (23.1%), additionally revealing that total T cell numbers and total lymphocyte numbers also contribute in predicting frailty. In-depth immune cellular profiling revealed consistent associations of frailty with elevated numbers of myeloid cell subpopulations in both men and women. Furthermore, additional associations were found between frailty and lower numbers of some T cell subpopulations, in women only. Thus, our study indicates sex-specific associations of immune subpopulations with frailty. We hope that our study will prompt further investigation into the sex-specific immune mechanisms associated with the development of frailty.",{"EN":1815},"In-depth immune cellular profiling reveals sex-specific associations with frailty",{"VOID":1817},"Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E. From discoveries in ageing research to therapeutics for healthy ageing. Nature. 2019; 571(7764):183–92. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41586-019-1365-2.\nFranceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014; 69(Suppl 1):4–9. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fgerona\u002Fglu057.\nSamson LD, Boots AMH, Verschuren WMM, Picavet HSJ, Engelfriet P, Buisman A-M. Frailty is associated with elevated CRP trajectories and higher numbers of neutrophils and monocytes. 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J Gerontol A Biol Sci Med Sci. 2001; 56(3):146–56. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fgerona\u002F56.3.m146.",{"VOID":1819},"10.1186\u002Fs12979-020-00191-z","https:\u002F\u002Fimmunityageing.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12979-020-00191-z",[1822,1846,1859,1872,1885,1898,1911,1933,1946],{"id":1823,"sortIndex":21,"researcher":20,"roles":1824,"affiliations":1825,"properties":1843,"displayName":1845,"givenName":20,"familyName":20},"3e9b53ad-3278-4902-9c67-e8c65ceeb74a",[971],[1826,1834],{"id":1827,"sortIndex":21,"affiliation":1828,"properties":20},"1fa15c6b-1657-4622-8aa6-eb2fdad0ee1d",{"id":1827,"createTime":20,"updateTime":20,"relativeEntities":1829,"slug":20,"properties":1830,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1833,"statistic":20},[],{"title":1831},{"VI":1832},"National Institute of Public Health and the Environment, Bilthoven, Netherlands",[],{"id":1835,"sortIndex":91,"affiliation":1836,"properties":1842},"1a8029bf-ed78-40c6-ae26-6bdc2776fcf1",{"id":1835,"createTime":20,"updateTime":20,"relativeEntities":1837,"slug":20,"properties":1838,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1841,"statistic":20},[],{"title":1839},{"VI":1840},"Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands",[],{},{"title":1844},{"VI":1845},"Leonard Daniël Samson",{"id":1847,"sortIndex":91,"researcher":20,"roles":1848,"affiliations":1849,"properties":1856,"displayName":1858,"givenName":20,"familyName":20},"6e8b7dd6-2745-4121-a5f7-ab4b7ff244bc",[971],[1850],{"id":1835,"sortIndex":21,"affiliation":1851,"properties":20},{"id":1835,"createTime":20,"updateTime":20,"relativeEntities":1852,"slug":20,"properties":1853,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1855,"statistic":20},[],{"title":1854},{"VI":1840},[],{"title":1857},{"VI":1858},"A. 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In the present study we have immunized a group of young adults against tetanus and diphtheria to compare the pre- and 28 days post-vaccination immune responses in the young group with results of the same vaccination performed in an elderly group of a previous study. We also studied protection in both groups 5 years after vaccination. We compared antibody titers at all three time points and also analyzed the T cell responses in both age groups 5 years after vaccination. Before vaccination 9 % of the elderly persons were not protected against tetanus, and 48 % did not have protection against diphtheria. In the young group all participants were protected against tetanus, but 52 % were also unprotected against diphtheria before vaccination. 28 days after vaccination 100 % of all participants had protective antibody concentrations against tetanus and only a small percentage in each age group (\u003C10 %) was unprotected against diphtheria. 5 years later, 100 % of both cohorts were still protected against tetanus, but 24 % of the young and 54 % of the elderly group were unprotected against diphtheria. Antibody concentrations against diphtheria measured by ELISA correlated well with their neutralizing capacity. T cell responses to tetanus and diphtheria did not differ between young and old persons. We conclude that booster vaccinations against tetanus and diphtheria according to present recommendations provide long-lasting protection only against tetanus, but not against diphtheria, independently of age. In elderly persons, the level of protection is even lower, probably due to intrinsic age-related changes within the immune system and\u002For insufficient vaccination earlier in life.",{"EN":2023},"Booster vaccination against tetanus and diphtheria: insufficient protection against diphtheria in young and elderly adults",{"VOID":2025},"Wichmann O, Ultsch B. Effectiveness, population-level effects, and heath economics of measles and rubella vaccination. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013;56:1260–9. doi:10.1007\u002Fs00103-013-1801-7.\nGalazka AM, Robertson SE, Oblapenko GP. Resurgence of diphtheria. Eur J Epidemiol. 1995;11:95–105.\nWorld Health Organization. Tetanus Vaccine-WHO position paper. Wkly Epidemiol Rec. 2006;81:198–208.\nWorld Health Organization. Diphtheria Vaccine-WHO position paper. Wkly Epidemiol Rec. 2006;81:24–31.\nRendi-Wagner P, Paulke-Korinek M. Impfplan Österreich 2016. 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PLoS One. 2012;7:e34145. doi:10.1371\u002Fjournal.pone.0034145.\nSasaki S, Sullivan M, Narvaez CF, Holmes TH, Furman D, Zheng N, et al. Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies. J Clin Invest. 2011;121:3109–19. doi:10.1172\u002FJCI57834.\nGlenny AT, Pope CG, Waddington H, Wallace U. Immunological notes. XVII–XXIV. J Pathol. 1926;29:31–40. doi:10.1002\u002Fpath.1700290106.\nde Gregorio E, Caproni E, Ulmer JB. Vaccine adjuvants: mode of action. Front Immunol. 2013;4:214. doi:10.3389\u002Ffimmu.2013.00214.\nAwate S, Babiuk LA, Mutwiri G. Mechanisms of action of adjuvants. Front Immunol. 2013;4:114. doi:10.3389\u002Ffimmu.2013.00114.\nChen Q, He F, Kwang J, Chan JK, Chen J. GM-CSF and IL-4 stimulate antibody responses in humanized mice by promoting T, B, and dendritic cell maturation. J Immunol. 2012;189:5223–9. doi:10.4049\u002Fjimmunol.1201789.\nWang X, Dong A, Xiao J, Zhou X, Mi H, Xu H, et al. Overcoming HBV immune tolerance to eliminate HBsAg-positive hepatocytes via pre-administration of GM-CSF as a novel adjuvant for a hepatitis B vaccine in HBV transgenic mice. Cell Mol Immunol. 2015. doi: 10.1038\u002Fcmi.2015.64.\nFollador I, Araujo C, Orge G, Cheng LH, de Carvalho LP, Bacellar O, et al. Immune responses to an inactive vaccine against American cutaneous leishmaniasis together with granulocyte-macrophage colony-stimulating factor. Vaccine. 2002;20:1365–8.\nShaw AC, Goldstein DR, Montgomery RR. Age-dependent dysregulation of innate immunity. Nat Rev Immunol. 2013;13:875–87. doi:10.1038\u002Fnri3547.\nGupta S. Role of dendritic cells in innate and adaptive immune response in human aging. Exp Gerontol. 2014;54:47–52. doi:10.1016\u002Fj.exger.2013.12.009.",{"VOID":2027},"10.1186\u002Fs12979-016-0081-0","http:\u002F\u002Fimmunityageing.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12979-016-0081-0",[2030,2045,2058,2073,2086],{"id":2031,"sortIndex":21,"researcher":20,"roles":2032,"affiliations":2033,"properties":2042,"displayName":2044,"givenName":20,"familyName":20},"014da08b-feb8-4d42-b70f-4422e8416d14",[971],[2034],{"id":2035,"sortIndex":21,"affiliation":2036,"properties":20},"2babf19b-abcd-48de-a4aa-b200fdf54e84",{"id":2035,"createTime":20,"updateTime":20,"relativeEntities":2037,"slug":20,"properties":2038,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":2041,"statistic":20},[],{"title":2039},{"VI":2040},"Institute for Biomedical Aging Research, Universität Innsbruck, Innsbruck, Austria",[],{"title":2043},{"VI":2044},"Marco 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(CMV) is a prevalent herpesvirus with links to both stress and aging. This paper describes and validates a minimally invasive method for assessing antibodies against CMV in finger stick whole blood spot samples for use as an indirect marker of an aspect of cell-mediated immunity. Analysis of CMV in dried blood spot samples (DBS) was based on modifications of a commercially available protocol for quantifying CMV antibodies in serum or plasma. The method was evaluated through analysis of precision, reliability, linearity, and correlation between matched serum and DBS samples collected from 75 volunteers. Correlation between DBS and plasma values was linear and high (Pearson correlation R = .96), and precision, reliability, and linearity of the DBS assay were within acceptable ranges. The validity of a DBS assay for CMV antibodies will enable its inclusion in population-based surveys and other studies collecting DBS samples in non-clinical settings, increasing scientific understanding of the interaction of social and biological stress and immune function.",{"EN":2162},"Cytomegalovirus antibodies in dried blood spots: a minimally invasive method for assessing stress, immune function, and aging",{"VOID":2164},"Castle SC: Clinical relevance of age-related immune dysfunction. Clinical Infectious Diseases. 2000, 31: 578-585. 10.1086\u002F313947.\nKarrer U, Mekker A, Wanke K, Tchang V, Haeberli L: Cytomegalovirus and immune senescence: Culprit or innocent bystander?. Experimental Gerontology. 2009, 44: 689-694. 10.1016\u002Fj.exger.2009.09.003.\nPawelec G, Derhovanessian E, Larbi A, Strindhall J, Wikby A: Cytomegalovirus and human immunosenescence. Reviews in Medical Virology. 2009, 19: 47-56. 10.1002\u002Frmv.598.\nMcDade TW, Williams S, Snodgrass JJ: What a drop can do: dried blood spots as a minimally invasive method for integrating biomarkers into population-based research. Demography. 2007, 44: 899-925. 10.1353\u002Fdem.2007.0038.\nBate SL, Dollard SC, Cannon MJ: Cytomegalovirus Seroprevalence in the United States: The National Health and Nutrition Examination Surveys, 1988-2004. Clinical Infectious Diseases. 2010, 50: 1439-1447. 10.1086\u002F652438.\nCannon M, Schmid DS, Hyde T: Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection. Reviews in Medical Virology. 2010, 20: 202-213. 10.1002\u002Frmv.655.\nStowe RP, Kozlova EV, Yetman DL, Walling DM, Goodwin JS, Glaser R: Chronic herpesvirus reactivation occurs in aging. Experimental Gerontology. 2007, 42: 563-570. 10.1016\u002Fj.exger.2007.01.005.\nDerhovanessian E, Larbi A, Pawelec G: Biomarkers of human immunosenescence: impact of Cytomegalovirus infection. Current Opinion in Immunology. 2009, 21: 440-445. 10.1016\u002Fj.coi.2009.05.012.\nVezys V, Yates A, Casey K, Lanier G, Ahmed R, Antia R, Masopust D: Memory CD8 T-cell compartment grows in size with immunological experience. Nature. 2009, 457: 196-199. 10.1038\u002Fnature07486.\nOlsson J, Wikby A, Johansson B, Lofgren S, Nilsson BO, Ferguson FG: Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech Ageing Dev. 2000, 121: 187-201. 10.1016\u002FS0047-6374(00)00210-4.\nPourgheysari B, Khan N, Best D, Bruton R, Nayak L, Moss PAH: The cytomegalovirus-specific CD4+ T-cell response expands with age and markedly alters the CD4+ T-cell repertoire. Journal of Virology. 2007, 81: 7759-7765. 10.1128\u002FJVI.01262-06.\nSylwester AW, Mitchell BL, Edgar JB, Taormina C, Pelte C, Ruchti F, Sleath PR, Grabstein KH, Hosken NA, Kern F: Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. Journal of Experimental Medicine. 2005, 202: 673-685. 10.1084\u002Fjem.20050882.\nCP Kuo, CL Wu, HT Ho, Chen CG, SI Liu, YT Lu: Detection of cytomegalovirus reactivation in cancer patients receiving chemotherapy. Clinical Microbiology and Infection. 2008, 14: 221-227. 10.1111\u002Fj.1469-0691.2007.01895.x.\nvan Zanten J, Harmsen MC, van der Giessen M, van der Bij W, Prop J, de Leij L, The TH: Humoral immune response against human cytomegalovirus (HCMV)-specific proteins after HCMV infection in lung transplantation as detected with recombinant and naturally occurring proteins. Clin Diagn Lab Immunol. 1995, 2: 214-218.\nTrzonkowski P, Mysliwska J, Szmit E, Wieckiewicz J, Lukaszuk K, Brydak LB, Machala M, Mysliwski A: Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination--an impact of immunosenescence. Vaccine. 2003, 21: 3826-3836. 10.1016\u002FS0264-410X(03)00309-8.\nAlmanzar G, Schwaiger S, Jenewein B, Keller M, Herndler-Brandstetter D, Wurzner R, Schonitzer D, Grubeck-Loebenstein B: Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons. J Virol. 2005, 79: 3675-83. 10.1128\u002FJVI.79.6.3675-3683.2005.\nRoberts E, Haan M, Dowd J, Aiello A: Cytomegalovirus Antibody Levels, Inflammation, and Mortality among Elderly Latinos over 9 years of Follow-up. American Journal of Epidemiology. 2010, 172: 363-371. 10.1093\u002Faje\u002Fkwq177.\nSorlie PD, Nieto FJ, Adam E, Folsom AR, Shahar E, Massing M: A Prospective Study of Cytomegalovirus, Herpes Simplex Virus 1, and Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study. Arch Intern Med. 2000, 160: 2027-2032. 10.1001\u002Farchinte.160.13.2027.\nAiello AE, Haan MN, Blythe L, Moore K, Gonzalez JM, Jagust W: The Influence of Latent Viral Infection on Rate of Cognitive Decline over 4 Years. Journal of the American Geriatrics Society. 2006, 54: 1046-1054. 10.1111\u002Fj.1532-5415.2006.00796.x.\nSchmaltz HN, Fried LP, QL Xue, Walston J, Leng SX, Semba RD: Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women. J Am Geriatr Soc. 2005, 53: 747-54. 10.1111\u002Fj.1532-5415.2005.53250.x.\nStrandberg TE, Pitkala KH, Linnavuori K, Tilvis RS: Cognitive impairment and infectious burden in the elderly. Arch Gerontol Geriatr Suppl. 2004, 9: 419-23. 10.1016\u002Fj.archger.2004.04.053.\nHerbert TB, Cohen S: Stress and immunity in humans: a meta-analytic review. Psychosom Med. 1993, 55: 364-379.\nGlaser R, Friedman SB, Smyth J, Ader R, Bijur P, Brunell P, Cohen N, Krilov LR, Lifrak ST, Stone A: The Differential Impact of Training Stress and Final Examination Stress on Herpesvirus Latency at the United States Military Academy at West Point. Brain, Behavior, and Immunity. 1999, 13: 240-251. 10.1006\u002Fbrbi.1999.0566.\nSarid O, Anson O, Yaari A, Margalith M: Human cytomegalovirus salivary antibodies as related to stress. Clin Lab. 2002, 48: 297-305.\nGlaser R, Kiecolt-Glaser JK: Chronic stress modulates the virus-specific immune response to latent herpes simplex virus type 1. Ann Behav Med. 1997, 19: 78-82. 10.1007\u002FBF02883323.\nMcDade TW, Stallings JF, Angold A, Costello EJ, Burleson M, Cacioppo JT, Glaser R, Worthman CM: Epstein-Barr Virus Antibodies in Whole Blood Spots: A Minimally Invasive Method for Assessing an Aspect of Cell-Mediated Immunity. Psychosom Med. 2000, 62: 560-568.\nShirtcliff EA, Coe CL, Pollak SD: Early childhood stress is associated with elevated antibody levels to herpes simplex virus type 1. Proceedings of the National Academy of Sciences of the United States of America. 2009, 106: 2963-7. 10.1073\u002Fpnas.0806660106.\nEsterling BA, Antoni MH, Kumar M, Schneiderman N: Defensiveness, trait anxiety, and Epstein-Barr viral capsid antigen antibody titers in healthy college students. Health Psychol. 1993, 12: 132-9. 10.1037\u002F0278-6133.12.2.132.\nGlaser R, Kiecolt-Glaser JK, Speicher CE, Holliday JE: Stress, loneliness, and changes in herpesvirus latency. J Behav Med. 1985, 8: 249-60. 10.1007\u002FBF00870312.\nMehta SK, Stowe RP, Feiveson AH, Tyring SK, Pierson DL: Reactivation and shedding of cytomegalovirus in astronauts during spaceflight. J Infect Dis. 2000, 182: 1761-4. 10.1086\u002F317624.\nPhillips AC, Carroll D, Khan N, Moss P: Cytomegalovirus is associated with depression and anxiety in older adults. Brain, Behavior, and Immunity. 2008, 22: 52-55. 10.1016\u002Fj.bbi.2007.06.012.\nCaserta MT, O'Connor TG, Wyman PA, Wang H, Moynihan J, Cross W, Tu X, Jin X: The associations between psychosocial stress and the frequency of illness, and innate and adaptive immune function in children. Brain, Behavior, and Immunity. 2008, 22: 933-940. 10.1016\u002Fj.bbi.2008.01.007.\nKoment RW: Lytic cytomegalovirus replication and the hormones of human pregnancy. J Med Virol. 1985, 15: 149-56. 10.1002\u002Fjmv.1890150207.\nLathey JL, Spector SA: Unrestricted replication of human cytomegalovirus in hydrocortisone-treated macrophages. J Virol. 1991, 65: 6371-5.\nTanaka J, Ogura T, Kamiya S, Sato H, Yoshie T, Ogura H, Hatano M: Enhanced replication of human cytomegalovirus in human fibroblasts treated with dexamethasone. J Gen Virol. 1984, 65 (Pt 10): 1759-67. 10.1099\u002F0022-1317-65-10-1759.\nProsch S, Wendt CEC, Reinke P, Priemer C, Oppert M, Kruger DH, Volk HD, Docke WD: A Novel Link between Stress and Human Cytomegalovirus (HCMV) Infection: Sympathetic Hyperactivity Stimulates HCMV Activation. Virology. 2000, 272: 357-365. 10.1006\u002Fviro.2000.0367.\nWeinstein M, Vaupel James W, Wachter Kenneth W: Biosocial Surveys. 2008, Washington, D.C.: National Academies Press\nHenley W, Henley G: Epstein-Barr virus and infectious mononulceosis. Human herpesvirus infections: clinical aspects. Edited by: G-ST Glaser R. 1982, New York: Marcel Dekker, 151-62.\nStaras SAS, Dollard SC, Radford KW, Dana Flanders W, Pass RF, Cannon MJ: Seroprevalence of Cytomegalovirus Infection in the United States, 1988-1994. Clin Infect Dis. 2006, 43: 1143-1151. 10.1086\u002F508173.\nBland J, Altman D: Measuring agreement in method comparison studies. Statistical Methods in Medical Research. 1999, 135-60. 10.1191\u002F096228099673819272.\nVescovini R, Telera A, Fagnoni FF, Biasini C, Medici MC, Valcavi P, di Pede P, Lucchini G, Zanlari L, Passeri G: Different contribution of EBV and CMV infections in very long-term carriers to age-related alterations of CD8+ T cells. Experimental Gerontology. 2004, 39: 1233-1243. 10.1016\u002Fj.exger.2004.04.004.\nDowd JB, Simanek AM, Aiello AE: Socio-economic status, cortisol and allostatic load: a review of the literature. Int J Epidemiol. 2009, dyp277-\nDowd JB, Aiello AE, Alley DE: Socioeconomic disparities in the seroprevalence of cytomegalovirus infection in the US population: NHANES III. Epidemiology and Infection. 2009, 137: 58-65. 10.1017\u002FS0950268808000551.\nDowd JB, Aiello AE: Socioeconomic Differentials in Immune Response. Epidemiology. 2009, 20: 902-908. 10.1097\u002FEDE.0b013e3181bb5302.",{"VOID":2166},"10.1186\u002F1742-4933-8-3","https:\u002F\u002Fimmunityageing.biomedcentral.com\u002Farticles\u002F10.1186\u002F1742-4933-8-3",[2169,2193,2217,2232,2245],{"id":2170,"sortIndex":21,"researcher":20,"roles":2171,"affiliations":2172,"properties":2190,"displayName":2192,"givenName":20,"familyName":20},"6104b294-c347-4a2e-9af1-192af8cab3ca",[971],[2173,2181],{"id":2174,"sortIndex":21,"affiliation":2175,"properties":20},"64057ef3-38fe-42cf-b2d8-43397b708aa8",{"id":2174,"createTime":20,"updateTime":20,"relativeEntities":2176,"slug":20,"properties":2177,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":2180,"statistic":20},[],{"title":2178},{"VI":2179},"Epidemiology and Biostatistics, Hunter College, CUNY School of Public Health, 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people have experienced several influenza natural infections and seasonal vaccinations during their lives. The aim of this work was to evaluate in an elderly Spanish population the presence of antibodies (Abs) against some 1940s era A\u002FH1N1 influenza viruses and some new influenza viruses. We also evaluated the homologous and heterotypic responses after seasonal influenza vaccination. We collected pre- and post-vaccination serum samples from 174 elderly people (≥65 years) who were vaccinated with seasonal influenza vaccines during the 2006–2007, 2008–2009, 2009–2010, and 2010–2011 northern hemisphere influenza campaigns. The presence of Abs against the 1940s era A\u002FWeiss\u002F43 and A\u002FFM\u002F1\u002F47 strains of the A\u002FH1N1 influenza virus was evaluated by using hemagglutination inhibition assays. Pre-vaccination Abs against the A\u002FWeiss\u002F43 and A\u002FFM\u002F1\u002F47 strains were present at protective titres (≥1\u002F40) in 43.7% and 20.1% of the study population respectively. Seasonal influenza vaccination induced heterotypic seroconversion against A\u002FWeiss\u002F43 in 16.1% of the individuals and against A\u002FFM\u002F1\u002F47 in 13.2% of the individuals. The seroprotection rate for the study population after seasonal vaccination was 63.2% against A\u002FWeiss\u002F43 and 31.0% against A\u002FFM\u002F1\u002F47. The heterotypic response did not satisfy the European Medicament Agency criteria for people aged ≥60 years. A moderate percentage of elderly people had Abs against the 1940s era A\u002FWeiss\u002F43 and A\u002FFM\u002F1\u002F47 strains of the A\u002FH1N1 influenza subtype. Seasonal influenza vaccination induced a low but significant heterotypic response against both 1940s era influenza strains, reaching a high seroprotection rate for the A\u002FWeiss\u002F43 strain. Seasonal influenza vaccination can increase, within certain limitations, the Abs titres against old influenza strains not included in the composition of the vaccine itself.",{"EN":2331},"Antibodies against 1940s era a\u002FH1N1 influenza strains a\u002FWeiss\u002F43 and a\u002FFM\u002F1\u002F47 and heterotypic responses after seasonal vaccination of an elderly Spanish 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Available from: http:\u002F\u002Fecdc.europa.eu\u002Fen\u002Fhealthtopics\u002Fseasonal_influenza\u002Fvaccines\u002FPages\u002Finfluenza_vaccination.aspx#riskgroups",{"id":20,"text":2509,"url":20,"identifiers":20},"Glezen WP, Keitel WA, Taber LH, Piedra PA, Clover RD, Couch RB. Age distribution of patients with medically-attended illnesses caused by sequential variants of influenza a\u002FH1N1: comparison to age-specific infection rates, 1978-1989. Am J Epidemiol. 1991;133:296–304.",{"id":20,"text":2511,"url":20,"identifiers":20},"Sanz I, Rojo S, Tamames S, Eiros JM, Ortiz de Lejarazu R. Heterologous humoral response against H5N1, H7N3, and H9N2 avian influenza viruses after seasonal vaccination in a European elderly population. Vaccine. 2017 Jul 17;5(3)",{"id":20,"text":2513,"url":20,"identifiers":20},"Staneková Z, Varečková E. Conserved epitopes of influenza a virus inducing protective immunity and their prospects for universal vaccine development. Virol J. 2010;7:351.",{"id":20,"text":2515,"url":20,"identifiers":20},"Epstein SL, Price GE. Cross-protective immunity to influenza a viruses. Expert Rev Vaccines. 2010;9:1325–41.",{"id":20,"text":2517,"url":20,"identifiers":20},"WHO. Recommendations for Influenza Vaccine Composition: Northern hemisphere: 2006–2007 [Internet]. 2006 [cited 2016 Nov 18]. Available from: www.who.int\u002Fentity\u002Finfluenza\u002Fvaccines\u002F2007northreport.pdf",{"id":20,"text":2519,"url":20,"identifiers":20},"WHO. Recommended composition of influenza virus vaccines for use in the 2008–2009 influenza season [Internet]. 2008 [cited 2017 Oct 20]. Available from: www.who.int\u002Fentity\u002Finfluenza\u002Fvaccines\u002Frecommended_compositionFeb08FullReport.pdf",{"id":20,"text":2521,"url":20,"identifiers":20},"WHO. Recommended composition of influenza virus vaccines for use in the 2009–2010 influenza season [Internet]. 2009 [cited 2017 Oct 20]. Available from: www.who.int\u002Fentity\u002Finfluenza\u002Fvaccines\u002F200902_recommendation.pdf",{"id":20,"text":2523,"url":20,"identifiers":20},"WHO. Recommended viruses for influenza vaccines for use in the 2010–11 northern hemisphere influenza season [Internet]. 2010 [cited 2017 Oct 20]. Available from: www.who.int\u002Fentity\u002Finfluenza\u002Fvaccines\u002Fvirus\u002Frecommendations\u002F201002_Recommendation.pdf",{"id":20,"text":2525,"url":20,"identifiers":20},"Nakajima S, Nishikawa F, Nakajima K. Comparison of the evolution of recent and late phase of old influenza a (H1N1) viruses. Microbiol Immunol. 2000;44:841–7.",{"id":20,"text":2527,"url":20,"identifiers":20},"Kilbourne ED, Smith C, Brett I, Pokorny BA, Johansson B, Cox N. The total influenza vaccine failure of 1947 revisited: major intrasubtypic antigenic change can explain failure of vaccine in a post-world war II epidemic. 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Note for guiadance on harmonisation of requirements for influenza vaccines (CPMP\u002FBWP\u002F214\u002F96) [Internet]. 1997 [cited 2017 Oct 20]. Available from: http:\u002F\u002Fwww.ema.europa.eu\u002Fdocs\u002Fen_GB\u002Fdocument_library\u002FScientific_guideline\u002F2009\u002F09\u002FWC500003945.pdf",{"id":20,"text":2537,"url":20,"identifiers":20},"Trombetta CM, Perini D, Mather S, Temperton N, Montomoli E. Overview of serological techniques for influenza vaccine evaluation: past, present and future. Vaccine. 2014;2:707–34.",{"id":20,"text":2539,"url":20,"identifiers":20},"Petrie JG, Ohmit SE, Johnson E, Truscon R, Monto AS. Persistence of antibodies to influenza hemagglutinin and neuraminidase following one or two years of influenza vaccination. J Infect Dis. 2015 Dec 15;212(12):1914–22.",{"id":20,"text":2541,"url":20,"identifiers":20},"Dou Y, Fu B, Sun R, Li W, Hu W, Tian Z, et al. Influenza vaccine induces intracellular immune memory of human NK cells. PLoS One. 2015;10:e0121258.",{"id":20,"text":2543,"url":20,"identifiers":20},"Bonduelle O, Carrat F, Luyt C-E, Leport C, Mosnier A, Benhabiles N, et al. Characterization of pandemic influenza immune memory signature after vaccination or infection. J Clin Invest. 2014;124:3129–36.",{"id":20,"text":2545,"url":20,"identifiers":20},"Laurie KL, Carolan LA, Middleton D, Lowther S, Kelso A, Barr IG. Multiple infections with seasonal influenza a virus induce cross-protective immunity against a(H1N1) pandemic influenza virus in a ferret model. J Infect Dis. 2010;202:1011–20.",{"id":20,"text":2547,"url":20,"identifiers":20},"Chen C-J, Ermler ME, Tan GS, Krammer F, Palese P, Hai R. Influenza a viruses expressing intra- or intergroup chimeric hemagglutinins. J Virol. 2016;90:3789–93.",{"id":20,"text":2549,"url":20,"identifiers":20},"Ermler ME, Kirkpatrick E, Sun W, Hai R, Amanat F, Chromikova V, et al. Chimeric hemagglutinin constructs induce broad protection against influenza B virus challenge in the mouse model. J Virol. 2017;91",{"id":20,"text":2551,"url":20,"identifiers":20},"Chen Y, Zheng Q, Yang K, Zeng F, Lau S-Y, Wu WL, et al. Serological survey of antibodies to influenza a viruses in a group of people without a history of influenza vaccination. Clin Microbiol Infect. 2011;17(9):1347.",{"id":20,"text":2553,"url":20,"identifiers":20},"Chi CY, Liu CC, Lin CC, Wang HC, Cheng YT, Chang CM, et al. Preexisting antibody response against 2009 pandemic influenza H1N1 viruses in the Taiwanese population. Clin Vaccine Immunol. 2010;17:1958–62.",{"id":20,"text":2555,"url":20,"identifiers":20},"Hancock K, Veguilla V, Lu X, Zhong W, Butler EN, Sun H, et al. Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus. N Engl J Med. 2009;361:1945–52.",{"id":20,"text":2557,"url":20,"identifiers":20},"Miller E, Hoschler K, Hardelid P, Stanford E, Andrews N, Zambon M. Incidence of 2009 pandemic influenza a H1N1 infection in England: a cross-sectional serological study. Lancet. 2010;375:1100–8.",{"id":20,"text":2559,"url":20,"identifiers":20},"Ortiz de Lejarazu R, Landínez R. Importancia epidemiológica de la nueva variante de virus gripal A\u002FUSSR\u002F90\u002F77. Laboratorio. 1978;66:339–50.",{"id":20,"text":2561,"url":20,"identifiers":20},"Kim JH, Skountzou I, Compans R, Jacob J. Original antigenic sin responses to influenza viruses. J Immunol. 2009;183:3294–301.",{"id":20,"text":2563,"url":20,"identifiers":20},"Thomas Francis, Jr. On the doctrine of original antigenic sin. Proc Am Philos Soc 1960;104:572–578.",{"id":20,"text":2565,"url":20,"identifiers":20},"Davenport FM, Hennessy AV. A serologic recapitulation of past experiences with influenza a; antibody response to monovalent vaccine. J Exp Med. 1956;104:85–97.",{"id":20,"text":2567,"url":20,"identifiers":20},"Kim JH, Davis WG, Sambhara S, Jacob J. Strategies to alleviate original antigenic sin responses to influenza viruses. Proc Natl Acad Sci U S A. 2012;109:13751–6.",{"id":20,"text":2569,"url":20,"identifiers":20},"Morens DM, Burke DS, Halstead SB. The wages of original antigenic sin. Emerg Infect Dis. 2010;16:1023–4.",{"id":20,"text":2571,"url":20,"identifiers":20},"null F d SG, Webster RG. Disquisitions of original antigenic sin. I. Evidence in man. J Exp Med. 1966;124:331–45.",{"id":20,"text":2573,"url":20,"identifiers":20},"Peeters B, Reemers S, Dortmans J, de Vries E, de Jong M, van de Zande S, et al. Genetic versus antigenic differences among highly pathogenic H5N1 avian influenza a viruses: consequences for vaccine strain selection. Virology. 2017 Mar;503:83–93.",{"id":20,"text":2575,"url":20,"identifiers":20},"Plans-Rubió P. The vaccination coverage required to establish herd immunity against influenza viruses. Prev Med. 2012;55:72–7.",{"id":20,"text":2577,"url":20,"identifiers":20},"Mooring EQ, Bansal S. Increasing herd immunity with influenza revaccination. Epidemiol Infect. 2016;144:1267–77.",{"id":2579,"createTime":2580,"updateTime":2580,"relativeEntities":2581,"slug":20,"properties":2582,"entityType":964,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":2591,"fullTextUrl":20,"authors":2592,"publicationType":1214,"publisherRelationship":2710,"citationCount":20,"citationInfo":20,"publishDate":2760,"publishYear":2761,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":2762,"openAccess":20,"references":20,"isForceReanalyzing":1269},"0859acd2-19af-4deb-b57f-e0d0e55050a7","2024-02-06T20:38:59.389+00:00",[],{"abstract":2583,"title":2585,"references":2587,"doi":2589},{"EN":2584},"Poly(ADP-ribosyl)ation is a posttranslational modification of nuclear proteins catalysed by poly(ADP-ribose) polymerases (PARPs), using NAD+ as a substrate. Activation of PARP-1 is in immediate response to DNA damage generated by endogenous and exogenous damaging agents. It has been implicated in several crucial cellular processes including DNA repair and maintenance of genomic stability, which are both intimately linked with the ageing process. The measurement of cellular poly(ADP-ribosyl)ation capacity, defined as the amount of poly(ADP-ribose) produced under maximal stimulation, is therefore relevant for research on ageing, as well as for a variety of other scientific questions. This paper reports a new, robust protocol for the measurement of cellular poly(ADP-ribosyl)ation capacity in PBMC or Jurkat T-cells using flow cytometry, based on a previously established immuno-dot-blot assay. In order to validate the new assay, we determined the dose-response curve of 3-aminobenzamide, a well-known competitive PARP inhibitor, and we derived an IC50 that is very close to the published value. When testing a set of PBMC samples taken from fifteen healthy young human donors, we could confirm the presence of a substantial interindividual variation, as previously observed using a radiometric assay. The methodology described in this paper should be generally useful for the determination of cellular poly(ADP-ribosyl)ation capacity in a wide variety of settings, especially for the comparison of large sets of samples, such as population studies. In contrast to previously published radiometric or immuno-dot-blot assays, the new FACS-based method allows (i) selective analysis of mononuclear cells by gating and (ii) detection of a possible heterogeneity in poly(ADP-ribosyl)ation capacity between cells of the same type.",{"EN":2586},"Flow-cytometric assessment of cellular poly(ADP-ribosyl)ation capacity in peripheral blood lymphocytes",{"VOID":2588},"Fülöp T, Larbi A, Wikby A, Mocchegiani E, Hirokawa K, Pawelec G: Dysregulation of T-cell function in the elderly: scientific basis and clinical implications. Drugs Aging. 2005, 22: 589-603. 10.2165\u002F00002512-200522070-00005.\nBeneke S, Bürkle A: Poly(ADP-ribosyl)ation, PARP, and aging. Sci Aging Knowledge Environ. 2004, 49: re9-10.1126\u002Fsageke.2004.49.re9.\nBürkle A: Poly(ADP-ribose): The most elaborate metabolite of NAD+. FEBS J. 2005, 272: 4576-4589. 10.1111\u002Fj.1742-4658.2005.04864.x.\nde Boer J, Andressoo JO, de Wit J, Huijmans J, Beems RB, van Steeg H, Weeda G, van der Horst GT, van Leeuwen W, Themmen AP, Meradji M, Hoeijmakers JH: Premature aging in mice deficient in DNA repair and transcription. Science. 2002, 296: 1276-1279. 10.1126\u002Fscience.1070174.\nMocchegiani E, Marcellini F, Pawelec G: Nutritional zinc, oxidative stress and immunosenescence: biochemical, genetic, and lifestyle implications for healthy ageing. Biogerontology. 2004, 5: 271-273. 10.1023\u002FB:BGEN.0000038048.11766.64.\nHartwig A, Asmuss M, Ehleben I, Herzer U, Kostelac D, Pelzer A, Schwerdtle T, Bürkle A: Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms. Environ Health Perspect. 2002, 5: 797-799.\nBürkle A, ed: Poly(ADP-ribosyl)ation. 2006, Georgetown, TX, USA, Landes Bioscience, ISBN: 0-387-33371-1\nScovassi AI: Mitochondrial poly(ADP-ribosylation): from old data to new perspectives. FASEB J. 2004, 18: 1487-1488. 10.1096\u002Ffj.04-1841rev.\nMalanga M, Althaus FR: The role of poly(ADP-ribose) in the DNA damage signaling network. Biochem Cell Biol. 2005, 83: 354-364. 10.1139\u002Fo05-038.\nOei SL, Keil C, Ziegler M: Poly(ADP-ribosylation) and genomic stability. Biochem Cell Biol. 2005, 83: 263-269. 10.1139\u002Fo05-039.\nCurtin NJ: PARP inhibitors for cancer therapy. Expert Rev Mol Med. 2005, 7: 1-20. 10.1017\u002FS146239940500904X.\nBryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, Kyle S, Meuth M, Curtin NJ, Helleday T: Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature. 2005, 434: 913-917. 10.1038\u002Fnature03443.\nGrube K, Bürkle A: Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span. Proc Natl Acad Sci USA. 1992, 89: 11759-11763. 10.1073\u002Fpnas.89.24.11759.\nMuiras M-L, Müller M, Schächter F, Bürkle A: Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians. J Mol Med. 1998, 76: 346-354. 10.1007\u002Fs001090050226.\nHartwig A, Pelzer A, Asmuss M, Bürkle A: Very low concentrations of arsenite suppress poly(ADP-ribosyl)ation in mammalian cells. Int J Cancer. 2003, 104: 1-6. 10.1002\u002Fijc.10911.\nGrube K, Küpper JH, Bürkle A: Direct stimulation of poly(ADP ribose) polymerase in permeabilized cells by double-stranded DNA oligomers. Anal Biochem. 1991, 193: 236-239. 10.1016\u002F0003-2697(91)90015-L.\nPfeiffer R, Brabeck C, Bürkle A: Quantitative nonisotopic immuno-dot-blot method for the assessment of cellular poly(ADP-ribosyl)ation capacity. Anal Biochem. 1999, 275: 118-122. 10.1006\u002Fabio.1999.4286.\nOgata N, Ueda K, Kawaichi M, Hayaishi O: Poly(ADP-ribose) synthetase, a main acceptor of poly(ADP-ribose) in isolated nuclei. J Biol Chem. 1981, 256: 4135-4137.\nBanasik M, Komura H, Shimoyama M, Ueda K: Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. J Biol Chem. 1992, 267: 1569-1575.\nKawamitsu H, Hoshino H, Okada H, Miwa M, Momoi H, Sugimura T: Monoclonal antibodies to poly(adenosine diphosphate ribose) recognize different structures. Biochemistry. 1984, 23: 3771-3777. 10.1021\u002Fbi00311a032.",{"VOID":2590},"10.1186\u002F1742-4933-3-8","https:\u002F\u002Fimmunityageing.biomedcentral.com\u002Farticles\u002F10.1186\u002F1742-4933-3-8",[2593,2608,2621,2636,2649,2662,2677,2697],{"id":2594,"sortIndex":21,"researcher":20,"roles":2595,"affiliations":2596,"properties":2605,"displayName":2607,"givenName":20,"familyName":20},"7cf26385-6443-4fc5-891e-79a4543226a8",[971],[2597],{"id":2598,"sortIndex":21,"affiliation":2599,"properties":20},"e601c9fa-b41f-4d7f-9166-b5f6e550a7ca",{"id":2598,"createTime":20,"updateTime":20,"relativeEntities":2600,"slug":20,"properties":2601,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":2604,"statistic":20},[],{"title":2602},{"VI":2603},"Molecular Toxicology Group, Department of Biology, University of Konstanz, Germany",[],{"title":2606},{"VI":2607},"Andrea 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