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Tính di truyền và tác động của biến thể thường mạnh hơn ở nữ hơn là nam giới, và chúng tôi thấy khoảng một phần ba tổng số tín hiệu là khác nhau về giới tính. 5% cá thể mang các alen làm tăng WHRadjBMI nhiều nhất có khả năng cao gấp 1.62 lần so với 5% dưới cùng để có WHR vượt quá ngưỡng được sử dụng cho hội chứng chuyển hóa. 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