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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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In the Nottingham\u002FTenovus Primary Breast Cancer Study the most commonly used method, described by Bloom & Richardson, has been modified in order to make the criteria more objective. The revised technique involves semiquantitative evaluation of three morphological features–the percentage of tubule formation, the degree of nuclear pleomorphism and an accurate mitotic count using a defined field area. A numerical scoring system is used and the overall grade is derived from a summation of individual scores for the three variables; three grades of differentiation are used. Since 1973, over 2200 patients with primary operable breast cancer have been entered into a study of multiple prognostic factors. Histological grade, assessed in 1831 patients, shows a very strong correlation with prognosis; patients with grade I tumours have a significantly better survival than those with grade II and III tumours (P<0.0001). These results demonstrate that this method for histological grading provides important prognostic information and, if the grading protocol is followed consistently, reproducible results can be obtained. Histological grade forms part of the multifactorial Nottingham prognostic index, together with tumour size and lymph node stage, which is used to stratify individual patients for appropriate therapy.\u003C\u002Fjats:p>","Trong nhiều nghiên cứu, đánh giá về mức độ biệt hóa thông qua hình thái học đã cho thấy có giá trị trong việc cung cấp thông tin tiên lượng quan trọng cho bệnh ung thư vú. Tuy nhiên, cho đến gần đây, việc phân loại mô học vẫn chưa được chấp nhận như một quy trình thường xuyên, chủ yếu vì những vấn đề về tính nhất quán và độ chính xác. Trong Nghiên cứu Ung thư Vú Nguyên phát Nottingham\u002FTenovus, phương pháp phổ biến nhất do Bloom và Richardson mô tả đã được chỉnh sửa để làm cho các tiêu chí trở nên khách quan hơn. Kỹ thuật sửa đổi này bao gồm đánh giá bán định lượng ba đặc điểm hình thái: phần trăm sự hình thành ống dẫn, mức độ đa hình của nhân tế bào và đếm chính xác số lượng phân bào trong vùng trường xác định. Một hệ thống điểm số số được sử dụng và cấp độ tổng thể được tính toán từ tổng số điểm của từng biến số; ba mức độ biệt hóa được sử dụng. Từ năm 1973, hơn 2200 bệnh nhân với ung thư vú nguyên phát có thể phẫu thuật đã tham gia vào nghiên cứu các yếu tố tiên lượng đa chiều. Cấp độ mô học, được đánh giá trên 1831 bệnh nhân, cho thấy mối tương quan rất mạnh với tiên lượng; bệnh nhân có khối u ở cấp độ I có tỷ lệ sống sót cao hơn đáng kể so với những người có khối u ở cấp độ II và III (P\u003C0.0001). Những kết quả này chứng minh rằng phương pháp phân loại mô học này cung cấp thông tin tiên lượng quan trọng và nếu theo đúng giao thức phân loại, có thể đạt được kết quả đồng nhất. Cấp độ mô học là một phần của chỉ số tiên lượng Nottingham đa yếu tố, cùng với kích thước khối u và giai đoạn hạch bạch huyết, được sử dụng để phân tầng bệnh nhân phù hợp với liệu pháp thích hợp.",{"EN":972,"VI":973},"pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long‐term follow‐up","Các yếu tố tiên lượng bệnh lý trong ung thư vú. I. 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Surg., 195, 1",{},{"id":28,"text":1144,"url":28,"identifiers":1145},"10.1002\u002F1097-0142(19821201)50:11\u003C2410::AID-CNCR2820501128>3.0.CO;2-5",{"doi":1144},{"id":28,"text":1147,"url":28,"identifiers":1148},"10.1002\u002F1097-0142(19840201)53:3 \u003C712::AID-CNCR2820531320>3.0.CO;2-I",{"doi":1147},{"id":28,"text":1150,"url":28,"identifiers":1151},"10.1200\u002FJCO.1987.5.9.1378",{"doi":1150},{"id":28,"text":1153,"url":28,"identifiers":1154},"Hopton DS, 1989, Histological grading of breast cancer; significance of grade on recurrence and mortality, Eur. J. Surg Oncol., 15, 25",{},{"id":28,"text":1156,"url":28,"identifiers":1157},"Blamey RW, 1979, Prognostic factors in breast cancer–the formation of a prognostic index, Clin. Oncol., 5, 1",{},{"id":28,"text":1159,"url":28,"identifiers":1160},"10.1038\u002Fbjc.1982.62",{"doi":1159},{"id":28,"text":1162,"url":28,"identifiers":1163},"Scarff RW, 1968, Histological typing of breast tumours (international histological classification of tumours, no. 2)",{},{"id":28,"text":1165,"url":28,"identifiers":1166},"10.1002\u002F1097-0142(197507)36:1\u003C1::AID-CNCR2820360102>3.0.CO;2-4",{"doi":1165},{"id":28,"text":1168,"url":28,"identifiers":1169},"10.1002\u002F1097-0142(196601)19:1\u003C75::AID-CNCR2820190108>3.0.CO;2-4",{"doi":1168},{"id":28,"text":1171,"url":28,"identifiers":1172},"10.1136\u002Fjcp.32.10.979",{"doi":1171},{"id":28,"text":1174,"url":28,"identifiers":1175},"Hopton DS, 1989, Observer variation in histological grading of breast cancer, Eur. J. Surg. Oncol, 15, 21",{},{"id":28,"text":1177,"url":28,"identifiers":1178},"10.1097\u002F00000478-198207000-00002",{"doi":1177},{"id":28,"text":1180,"url":28,"identifiers":1181},"Ellis IO, 1987, The reltionship of histological type to survival and oestrogen receptor status in primary operable breast carcinoma, J. Pathol., 152, 219A",{},{"id":28,"text":1183,"url":28,"identifiers":1184},"10.1016\u002FS0046-8177(81)80235-3",{"doi":1183},{"id":28,"text":1186,"url":28,"identifiers":1187},"Mann R, 1985, Evaluation of mitotic activity as a component of histological grade and its contribution to prognosis in primary breast carcinoma, J. Pathol., 146, 271A",{},{"id":28,"text":1189,"url":28,"identifiers":1190},"Meyer JS, 1979, Advanced stage and early relapse of breast carcinomas associated with high thymidine labelling indices, Cancer Res., 39, 225",{},{"id":28,"text":1192,"url":28,"identifiers":1193},"10.1002\u002F1097-0142(19810301)47:5\u003C937::AID-CNCR2820470520>3.0.CO;2-6",{"doi":1192},{"id":28,"text":1195,"url":28,"identifiers":1196},"10.1002\u002Fpath.1711520407",{"doi":1195},{"id":28,"text":1198,"url":28,"identifiers":1199},"10.1038\u002Fbjc.1989.200",{"doi":1198},{"id":28,"text":1201,"url":28,"identifiers":1202},"10.1038\u002Fbjc.1988.60",{"doi":1201},{"id":28,"text":1204,"url":28,"identifiers":1205},"Auer G, 1984, Prognostic significance of nuclear DNA content in mammary adenocarcinoma in humans, Cancer Res., 44, 394",{},{"id":28,"text":1207,"url":28,"identifiers":1208},"10.1002\u002F1097-0142(19810815)48:4\u003C980::AID-CNCR2820480421>3.0.CO;2-7",{"doi":1207},{"id":28,"text":1210,"url":28,"identifiers":1211},"10.1016\u002F0014-2964(68)90081-9",{"doi":1210},{"id":28,"text":1213,"url":28,"identifiers":1214},"10.1002\u002Fbjs.1800740221",{"doi":1213},{"id":28,"text":1216,"url":28,"identifiers":1217},"10.1136\u002Fjcp.43.5.385",{"doi":1216},{"id":28,"text":1219,"url":28,"identifiers":1220},"10.1038\u002Fbjc.1991.101",{"doi":1219},{"id":28,"text":1222,"url":28,"identifiers":1223},"10.1016\u002F0277-5379(88)90171-X",{"doi":1222},{"id":28,"text":1225,"url":28,"identifiers":1226},"10.1056\u002FNEJM198811103191902",{"doi":1225},{"id":28,"text":1228,"url":28,"identifiers":1229},"Cox DR, 1972, Regression models and life‐tables, J. R. Stat. Soc. (B), 34, 187",{},{"id":28,"text":1231,"url":28,"identifiers":1232},"10.1038\u002Fbjc.1987.230",{"doi":1231},{"id":28,"text":1234,"url":28,"identifiers":1235},"Page DL, 1987, Diagnostic Histopathology of the Breast., 193",{},{"id":28,"text":1237,"url":28,"identifiers":1238},"Rosen PP, 1978, The pathological classification of human mammary carcinoma: past, present and future, Ann. Clin. Lab. Sci., 9, 144",{},{"id":28,"text":1240,"url":28,"identifiers":1241},"Royal College of Pathologists Working Group.NHSBreast Screening Programme Pathology Reporting in Breast Cancer Screening1990.",{},false,{"id":1244,"createTime":1245,"updateTime":1245,"relativeEntities":1246,"slug":1247,"properties":1248,"entityType":978,"verifyStatus":26,"verifyTime":1245,"verifyNote":1261,"languages":1262,"translateLanguages":28,"viewCount":32,"primaryUrl":1263,"fullTextUrl":28,"authors":1264,"publicationType":1012,"publisherRelationship":1282,"citationCount":1336,"citationInfo":1337,"publishDate":1342,"publishYear":1338,"citationAnalyzeStatus":883,"lastCitationAnalyze":28,"indexDatabases":1343,"openAccess":28,"references":1344,"isForceReanalyzing":1242},"5960f8d7-998f-4c12-9021-964a74b26197","2024-10-12T10:37:09.217+00:00",[],"Classification-of-colorectal-cancer-based-on-correlation-of-clinical-morphological-and-molecular-features",{"openalex":1249,"mag":1251,"abstract":1253,"title":1255,"pm":1257,"doi":1259},{"VOID":1250},"W2103547637",{"VOID":1252},"2103547637",{"EN":1254},"\u003Cjats:p>Over the last 20 years it has become clear that colorectal cancer (CRC) evolves through multiple pathways. These pathways may be defined on the basis of two molecular features: (i) DNA microsatellite instability (MSI) status stratified as MSI‐high (MSI‐H), MSI‐low (MSI‐L) and MS stable (MSS), and (ii) CpG island methylator phenotype (CIMP) stratified as CIMP‐high, CIMP‐low and CIMP‐negative (CIMP‐neg). In this review the morphological correlates of five molecular subtypes are outlined: Type 1 (CIMP‐high\u002FMSI‐H\u002F\u003Cjats:italic>BRAF\u003C\u002Fjats:italic> mutation), Type 2 (CIMP‐high\u002FMSI‐L or MSS\u002F\u003Cjats:italic>BRAF\u003C\u002Fjats:italic> mutation), Type 3 (CIMP‐low\u002FMSS or MSI‐L\u002F\u003Cjats:italic>KRAS\u003C\u002Fjats:italic> mutation), Type 4 (CIMP‐neg\u002FMSS) and Type 5 or Lynch syndrome (CIMP‐neg\u002FMSI‐H). The molecular pathways are determined at an early evolutionary stage and are fully established within precancerous lesions. Serrated polyps are the precursors of Types 1 and 2 CRC, whereas Types 4 and 5 evolve through the adenoma–carcinoma sequence. Type 3 CRC may arise within either type of polyp. Types 1 and 4 are conceived as having few, if any, molecular overlaps with each other, whereas Types 2, 3 and 5 combine the molecular features of Types 1 and 4 in different ways. This approach to the classification of CRC should accelerate understanding of causation and will impact on clinical management in the areas of both prevention and treatment.\u003C\u002Fjats:p>",{"EN":1256},"Classification of colorectal cancer based on correlation of clinical, morphological and molecular features",{"VOID":1258},"17204026",{"VOID":1260},"10.1111\u002Fj.1365-2559.2006.02549.x","Auto 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WM, 1998, Mutation of the type II transforming growth factor‐β receptor is coincident with the transformation of human colon adenomas to malignant carcinomas, Cancer Res., 58, 3101",{},{"id":28,"text":1409,"url":28,"identifiers":1410},"10.1309\u002FUYN70N9W2DVN9ART",{"doi":1409},{"id":28,"text":1412,"url":28,"identifiers":1413},"10.1007\u002Fs003840050211",{"doi":1412},{"id":28,"text":1415,"url":28,"identifiers":1416},"10.1002\u002Fhumu.1380020505",{"doi":1415},{"id":28,"text":1418,"url":28,"identifiers":1419},"10.1016\u002FS0002-9440(10)65503-4",{"doi":1418},{"id":28,"text":1421,"url":28,"identifiers":1422},"10.1002\u002F(SICI)1098-2264(199911)26:3\u003C247::AID-GCC9>3.0.CO;2-H",{"doi":1421},{"id":28,"text":1424,"url":28,"identifiers":1425},"10.1136\u002Fjcp.52.6.455",{"doi":1424},{"id":28,"text":1427,"url":28,"identifiers":1428},"10.1136\u002Fjcp.56.1.69",{"doi":1427},{"id":28,"text":1430,"url":28,"identifiers":1431},"Mirabelli‐Primdahl L, 1999, Beta‐catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway, Cancer Res., 59, 3346",{},{"id":28,"text":1433,"url":28,"identifiers":1434},"Miyaki M, 1999, Frequent mutation of β‐Catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer, Cancer Res., 59, 4506",{},{"id":28,"text":1436,"url":28,"identifiers":1437},"Johnson V, 2004, Exon 3 beta‐catenin mutations are specifically associated with colorectal carcinomas in the hereditary non‐polyposis colorectal cancer syndrome, Gut, 53, 264",{},{"id":28,"text":1439,"url":28,"identifiers":1440},"Samowitz WS, 1999, β‐catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas, Cancer Res., 59, 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Pathol., 3, 332",{},{"id":28,"text":1856,"url":28,"identifiers":1857},"10.1016\u002FS0002-9440(10)65436-3",{"doi":1856},{"id":1859,"createTime":1860,"updateTime":1860,"relativeEntities":1861,"slug":1862,"properties":1863,"entityType":978,"verifyStatus":26,"verifyTime":1860,"verifyNote":1261,"languages":1878,"translateLanguages":28,"viewCount":32,"primaryUrl":1879,"fullTextUrl":28,"authors":1880,"publicationType":1012,"publisherRelationship":2161,"citationCount":2215,"citationInfo":2216,"publishDate":2222,"publishYear":2217,"citationAnalyzeStatus":883,"lastCitationAnalyze":28,"indexDatabases":2223,"openAccess":28,"references":2224,"isForceReanalyzing":1242},"569a62d7-bbd3-4a4b-af14-977e85428b8c","2024-09-30T23:01:48.345+00:00",[],"Postmortem-examination-of-COVID-19-patients-reveals-diffuse-alveolar-damage-with-severe-capillary-congestion-and-variegated-findings-in-lungs-and-other-organs-suggesting-vascular-dysfunction",{"mag":1864,"pmc":1866,"openalex":1868,"abstract":1870,"title":1872,"pm":1874,"doi":1876},{"VOID":1865},"3021862213",{"VOID":1867},"7496150",{"VOID":1869},"W3021862213",{"EN":1871},"\u003Cjats:sec>\u003Cjats:title>Aims\u003C\u002Fjats:title>\u003Cjats:p>Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has rapidly evolved into a sweeping pandemic. Its major manifestation is in the respiratory tract, and the general extent of organ involvement and the microscopic changes in the lungs remain insufficiently characterised. Autopsies are essential to elucidate COVID‐19‐associated organ alterations.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods and results\u003C\u002Fjats:title>\u003Cjats:p>This article reports the autopsy findings of 21 COVID‐19 patients hospitalised at the University Hospital Basel and at the Cantonal Hospital Baselland, Switzerland. An \u003Cjats:italic>in‐corpore\u003C\u002Fjats:italic> technique was performed to ensure optimal staff safety. The primary cause of death was respiratory failure with exudative diffuse alveolar damage and massive capillary congestion, often accompanied by microthrombi despite anticoagulation. Ten cases showed superimposed bronchopneumonia. Further findings included pulmonary embolism (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 4), alveolar haemorrhage (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 3), and vasculitis (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 1). Pathologies in other organ systems were predominantly attributable to shock; three patients showed signs of generalised and five of pulmonary thrombotic microangiopathy. Six patients were diagnosed with senile cardiac amyloidosis upon autopsy. Most patients suffered from one or more comorbidities (hypertension, obesity, cardiovascular diseases, and diabetes mellitus). Additionally, there was an overall predominance of males and individuals with blood group A (81% and 65%, respectively). All relevant histological slides are linked as open‐source scans in supplementary files.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>This study provides an overview of postmortem findings in COVID‐19 cases, implying that hypertensive, elderly, obese, male individuals with severe cardiovascular comorbidities as well as those with blood group A may have a lower threshold of tolerance for COVID‐19. This provides a pathophysiological explanation for higher mortality rates among these patients.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":1873},"Postmortem examination of COVID‐19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction",{"VOID":1875},"32364264",{"VOID":1877},"10.1111\u002Fhis.14134",[31],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fhis.14134",[1881,1900,1917,1936,1951,1968,1985,2002,2019,2036,2055,2074,2093,2110,2127,2144],{"id":1882,"sortIndex":32,"researcher":28,"roles":1883,"affiliations":1884,"properties":1893},"e95f65bc-829d-49a5-b499-371892c66987",[],[1885],{"id":1886,"sortIndex":32,"affiliation":1887,"properties":28},"e345fb6d-e3d5-417f-8626-5fa3c85c7d00",{"id":1886,"createTime":28,"updateTime":28,"relativeEntities":1888,"slug":28,"properties":1889,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1892,"statistic":28},[],{"title":1890},{"VI":1891},"Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland",[],{"orcid":1894,"title":1896,"openalex":1898},{"VOID":1895},"https:\u002F\u002Forcid.org\u002F0000-0002-0847-6156",{"EN":1897},"Thomas Menter",{"VOID":1899},"A5026353001",{"id":1901,"sortIndex":40,"researcher":28,"roles":1902,"affiliations":1903,"properties":1910},"fc2cb58d-9c18-4c1c-a31f-ef7c71c139c4",[],[1904],{"id":1886,"sortIndex":32,"affiliation":1905,"properties":28},{"id":1886,"createTime":28,"updateTime":28,"relativeEntities":1906,"slug":28,"properties":1907,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1909,"statistic":28},[],{"title":1908},{"VI":1891},[],{"orcid":1911,"title":1913,"openalex":1915},{"VOID":1912},"https:\u002F\u002Forcid.org\u002F0000-0001-7609-8612",{"EN":1914},"Jasmin D. 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Seeking to identify antigens detectable in paraffin‐embedded sections that might allow a more complete, rational immunophenotypic classification of histiocytic\u002Fdendritic cell neoplasms, the International Lymphoma Study Group (ILSG) stained 61 tumours of suspected histiocytic\u002Fdendritic cell type with a panel of 15 antibodies including those reactive with histiocytes (CD68, lysozyme (LYS)), Langerhans cells (CD1a), follicular dendritic cells (FDC: CD21, CD35) and S100 protein. This analysis revealed that 57 cases (93%) fit into four major immunophenotypic groups (one histiocytic and three dendritic cell types) utilizing six markers: CD68, LYS, CD1a, S100, CD21, and CD35. The four (7%) unclassified cases were further classifiable into the above four groups using additional morphological and ultrastructural features. The four groups then included: (i) histiocytic sarcoma (\u003Cjats:italic>n\u003C\u002Fjats:italic>=18) with the following phenotype: CD68 (100%), LYS (94%), CD1a (0%), S100 (33%), CD21\u002F35 (0%). The median age was 46 years. Presentation was predominantly extranodal (72%) with high mortality (58% dead of disease (DOD)). Three had systemic involvement consistent with `malignant histiocytosis'; (ii) Langerhans cell tumour (LCT) (\u003Cjats:italic>n\u003C\u002Fjats:italic>=26) which expressed: CD68 (96%), LYS (42%), CD1a (100%), S100 (100%), CD21\u002F35 (0%). There were two morphological variants: cytologically typical (\u003Cjats:italic>n\u003C\u002Fjats:italic>=17) designated LCT; and cytologically malignant (\u003Cjats:italic>n\u003C\u002Fjats:italic>=9) designated Langerhans cell sarcoma (LCS). The LCS were often not easily recognized morphologically as LC‐derived, but were diagnosed based on CD1a staining. LCT and LCS differed in median age (33 versus 41 years), male:female ratio (3.7:1 versus 1:2), and death rate (31% versus 50% DOD). Four LCT patients had systemic involvement typical of Letterer–Siwe disease; (iii) follicular dendritic cell tumour\u002Fsarcoma (FDCT) (\u003Cjats:italic>n\u003C\u002Fjats:italic>=13) which expressed: CD68 (54%), LYS (8%), CD1a (0%), S100 (16%), FDC markers CD21\u002F35 (100%), EMA (40%). These patients were adults (median age 65 years) with predominantly localized nodal disease (75%) and low mortality (9% DOD); (iv) interdigitating dendritic cell tumour\u002Fsarcoma (IDCT) (\u003Cjats:italic>n\u003C\u002Fjats:italic>=4) which expressed: CD68 (50%), LYS (25%), CD1a (0%), S100 (100%), CD21\u002F35 (0%). The patients were adults (median 71 years) with localized nodal disease (75%) without mortality (0% DOD). In conclusion, definitive immunophenotypic classification of histiocytic and accessory cell neoplasms into four categories was possible in 93% of the cases using six antigens detected in paraffin‐embedded sections. Exceptional cases (7%) were resolvable when added morphological and ultrastructural features were considered. We propose a classification combining immunophenotype and morphology with five categories, including Langerhans cell sarcoma. This simplified scheme is practical for everyday diagnostic use and should provide a framework for additional investigation of these unusual neoplasms.\u003C\u002Fjats:p>",{"EN":2412},"Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases",{"VOID":2414},"12121233",{"VOID":2416},"10.1046\u002Fj.1365-2559.2002.01418.x",[31],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1046\u002Fj.1365-2559.2002.01418.x",[2420,2439,2456,2475,2494,2513,2532,2549,2566,2583,2602,2619,2638,2655,2672,2691,2708,2725,2742,2761,2778,2795,2812,2829,2846],{"id":2421,"sortIndex":32,"researcher":28,"roles":2422,"affiliations":2423,"properties":2432},"4e37b165-6edf-4670-9776-3cc20019dfbf",[],[2424],{"id":2425,"sortIndex":32,"affiliation":2426,"properties":28},"892a83b2-df99-46e8-9f4a-a2ea5f5e80e7",{"id":2425,"createTime":28,"updateTime":28,"relativeEntities":2427,"slug":28,"properties":2428,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2431,"statistic":28},[],{"title":2429},{"EN":2430},"Service of Pathologic Anatomy and Hematopathology, Bologna University, Italy,",[],{"orcid":2433,"title":2435,"openalex":2437},{"VOID":2434},"https:\u002F\u002Forcid.org\u002F0000-0001-8032-5128",{"EN":2436},"Stefano Pileri",{"VOID":2438},"A5043985252",{"id":2440,"sortIndex":40,"researcher":28,"roles":2441,"affiliations":2442,"properties":2451},"cddf15ef-d37a-4de6-832b-d3afa298eb13",[],[2443],{"id":2444,"sortIndex":32,"affiliation":2445,"properties":28},"66a0975c-074e-423d-8ce5-79d76bfb9e22",{"id":2444,"createTime":28,"updateTime":28,"relativeEntities":2446,"slug":28,"properties":2447,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2450,"statistic":28},[],{"title":2448},{"VI":2449},"Department of Pathology, University of Arizona, Tucson, AZ USA",[],{"title":2452,"openalex":2454},{"EN":2453},"Thomas M. 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Pathol. Lab. Med., 118, 183",{},{"id":28,"text":3172,"url":28,"identifiers":3173},"10.1111\u002Fj.1600-065X.1997.tb00955.x",{"doi":3172},{"id":28,"text":3175,"url":28,"identifiers":3176},"Gretz J, 1996, Sophisticated strategies for information and a higway for cell traffic, J. Immunol., 157, 495",{},{"id":28,"text":3178,"url":28,"identifiers":3179},"10.1097\u002F00000478-199808000-00005",{"doi":3178},{"id":28,"text":3181,"url":28,"identifiers":3182},"Nguyen D, 1994, Follicular dendritic cell sarcoma. Identification by monoclonal antibodies in paraffin sections, Appl. Immunohistochem., 2, 60",{},{"id":28,"text":3184,"url":28,"identifiers":3185},"Perez‐Ordonez B, 1998, Follicular dendritic cell tumor: review of the entity, Semin. Diagn. Pathol., 15, 144",{},{"id":28,"text":3187,"url":28,"identifiers":3188},"10.1111\u002Fj.1365-2559.1991.tb01500.x",{"doi":3187},{"id":3190,"createTime":3191,"updateTime":3191,"relativeEntities":3192,"slug":3193,"properties":3194,"entityType":978,"verifyStatus":26,"verifyTime":3207,"verifyNote":1261,"languages":3208,"translateLanguages":28,"viewCount":32,"primaryUrl":3209,"fullTextUrl":28,"authors":3210,"publicationType":1012,"publisherRelationship":3334,"citationCount":3388,"citationInfo":3389,"publishDate":3392,"publishYear":3390,"citationAnalyzeStatus":883,"lastCitationAnalyze":28,"indexDatabases":3393,"openAccess":28,"references":3394,"isForceReanalyzing":1242},"084c5c1a-7eff-4c5a-b890-639c4becbad1","2024-10-09T23:58:28.801+00:00",[],"Synovitis-score-discrimination-between-chronic-low-grade-and-high-grade-synovitis",{"openalex":3195,"mag":3197,"abstract":3199,"title":3201,"pm":3203,"doi":3205},{"VOID":3196},"W2167795966",{"VOID":3198},"2167795966",{"EN":3200},"\u003Cjats:p>\u003Cjats:bold>Aims\u003C\u002Fjats:bold> : To standardize the histopathological assessment of synovial membrane specimens in order to contribute to the diagnostics of rheumatic and non‐rheumatic joint diseases.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Methods and results\u003C\u002Fjats:bold> : Three features of chronic synovitis (enlargement of lining cell layer, cellular density of synovial stroma, leukocytic infiltrate) were semiquantitatively evaluated (from 0, absent to 3, strong) and each feature was graded separately. The sum provided the synovitis score, which was interpreted as follows: 0–1, no synovitis; 2–4, low‐grade synovitis; 5–9, high‐grade synovitis. Five hundred and fifty‐nine synovectomy specimens were graded by two independent observers. Clinical diagnoses were osteoarthrosis (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 212), post‐traumatic arthritis (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 21), rheumatoid arthritis (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 246), psoriatic arthritis (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 22), reactive arthritis (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 9), as well as controls (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 49) from autopsies of patients without joint damage. Median synovitis scores when correlated with clinical diagnoses were: controls 1.0, osteoarthritis 2.0, post‐traumatic arthritis 2.0, psoriatic arthritis 3.5, reactive arthritis 5.0 and rheumatoid arthritis 5.0. The scores differed significantly between most disease groups, especially between degenerative and rheumatic diseases. A high‐grade synovitis was strongly associated with rheumatic joint diseases (\u003Cjats:italic>P <\u003C\u002Fjats:italic> 0.001, sensitivity 61.7%, specificity 96.1%). The correlation between the two observers was high (\u003Cjats:italic>r =\u003C\u002Fjats:italic> 0.941).\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Conclusion\u003C\u002Fjats:bold> : The proposed synovitis score is based on well‐defined, reproducible histopathological criteria and may contribute to diagnosis in rheumatic and non‐rheumatic joint diseases.\u003C\u002Fjats:p>",{"EN":3202},"Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis",{"VOID":3204},"16978198",{"VOID":3206},"10.1111\u002Fj.1365-2559.2006.02508.x","2024-10-09T23:58:28.800+00:00",[31],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1365-2559.2006.02508.x",[3211,3228,3243,3262,3281,3298,3317],{"id":3212,"sortIndex":32,"researcher":28,"roles":3213,"affiliations":3214,"properties":3223},"807eb35e-9c04-478a-8491-f06a55d782f5",[],[3215],{"id":3216,"sortIndex":32,"affiliation":3217,"properties":28},"a21f1141-0eae-4e71-9733-3bede05f994f",{"id":3216,"createTime":28,"updateTime":28,"relativeEntities":3218,"slug":28,"properties":3219,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3222,"statistic":28},[],{"title":3220},{"EN":3221},"Institute for Pathology, Trier,Institute for Pathology",[],{"title":3224,"openalex":3226},{"EN":3225},"Veit Krenn",{"VOID":3227},"A5084510520",{"id":3229,"sortIndex":40,"researcher":28,"roles":3230,"affiliations":3231,"properties":3238},"fc063f02-a3a9-45ec-b018-142ac6fe3e66",[],[3232],{"id":3216,"sortIndex":32,"affiliation":3233,"properties":28},{"id":3216,"createTime":28,"updateTime":28,"relativeEntities":3234,"slug":28,"properties":3235,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3237,"statistic":28},[],{"title":3236},{"EN":3221},[],{"title":3239,"openalex":3241},{"EN":3240},"Lars Morawietz",{"VOID":3242},"A5055435458",{"id":3244,"sortIndex":123,"researcher":28,"roles":3245,"affiliations":3246,"properties":3255},"e7a42c69-92c4-4973-80b4-0a79bc8aa926",[],[3247],{"id":3248,"sortIndex":32,"affiliation":3249,"properties":28},"8a14c17a-c9ac-435b-b0c4-53306a36e932",{"id":3248,"createTime":28,"updateTime":28,"relativeEntities":3250,"slug":28,"properties":3251,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3254,"statistic":28},[],{"title":3252},{"EN":3253},"Department for Rheumatology, Charité University Hospital, Berlin",[],{"orcid":3256,"title":3258,"openalex":3260},{"VOID":3257},"https:\u002F\u002Forcid.org\u002F0000-0001-7518-1131",{"EN":3259},"Gerd R Burmester",{"VOID":3261},"A5076851275",{"id":3263,"sortIndex":42,"researcher":28,"roles":3264,"affiliations":3265,"properties":3274},"4acc0de3-fdc0-4e93-9d8d-5d4fef0faae1",[],[3266],{"id":3267,"sortIndex":32,"affiliation":3268,"properties":28},"d31297e1-9112-4def-85dd-bb12887f65db",{"id":3267,"createTime":28,"updateTime":28,"relativeEntities":3269,"slug":28,"properties":3270,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3273,"statistic":28},[],{"title":3271},{"EN":3272},"Experimental Rheumatology, University Jena, Jena",[],{"orcid":3275,"title":3277,"openalex":3279},{"VOID":3276},"https:\u002F\u002Forcid.org\u002F0000-0002-6104-482X",{"EN":3278},"Raimund W. 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Allg. Pathol., 135, 729",{},{"id":28,"text":3408,"url":28,"identifiers":3409},"Stiehl P., 1994, Histological classification of synovial membranes of rheumatoid arthritis in dependence on the kind of cell infiltrates, destruction of synovial lining cells as well as of course of disease, Z. Rheumatol., 50",{},{"id":28,"text":3411,"url":28,"identifiers":3412},"10.1002\u002Fart.1780390702",{"doi":3411},{"id":28,"text":3414,"url":28,"identifiers":3415},"10.1002\u002Fart.10556",{"doi":3414},{"id":28,"text":3417,"url":28,"identifiers":3418},"Stiehl P., 1997, Arthritiden., 188",{},{"id":28,"text":3420,"url":28,"identifiers":3421},"10.1186\u002Far4",{"doi":3420},{"id":28,"text":3423,"url":28,"identifiers":3424},"Hitchon CA, 2003, The histopathology of early synovitis, Clin. Exp. Rheumatol., 28",{},{"id":28,"text":3426,"url":28,"identifiers":3427},"10.1136\u002Fard.59.7.506",{"doi":3426},{"id":28,"text":3429,"url":28,"identifiers":3430},"10.1002\u002Fanr.1780320402",{"doi":3429},{"id":28,"text":3432,"url":28,"identifiers":3433},"10.1078\u002F0344-0338-5710261",{"doi":3432},{"id":28,"text":3435,"url":28,"identifiers":3436},"Krenn V, 1999, Molecular IgV(H) analysis demonstrates highly somatic mutated B cells in synovialitis of osteoarthritis: a degenerative disease is associated with a specific, not locally generated immune response, Lab. Invest., 79, 1377",{},{"id":28,"text":3438,"url":28,"identifiers":3439},"10.4049\u002Fjimmunol.162.5.3053",{"doi":3438},{"id":28,"text":3441,"url":28,"identifiers":3442},"10.1002\u002Fart.1780290816",{"doi":3441},{"id":28,"text":3444,"url":28,"identifiers":3445},"10.1002\u002Fart.1780310302",{"doi":3444},{"id":28,"text":3447,"url":28,"identifiers":3448},"10.1016\u002F0049-0172(73)90035-8",{"doi":3447},{"id":28,"text":3450,"url":28,"identifiers":3451},"Braun J, 1999, On the difficulties of establishing a consensus on the definition of and diagnostic investigations for reactive arthritis. Results and discussion of a questionnaire prepared for the 4th International Workshop on Reactive Arthritis, Berlin, Germany, July 3–6, 1999, J. Rheumatol., 27, 2185",{},{"id":28,"text":3453,"url":28,"identifiers":3454},"Krenn V., 2001, Surgical pathology updates. 18th European Congress of Pathology., 283",{},{"id":28,"text":3456,"url":28,"identifiers":3457},"10.1111\u002Fj.1523-1755.2004.00443.x",{"doi":3456},{"id":28,"text":3459,"url":28,"identifiers":3460},"10.1136\u002Fjcp.21.5.656",{"doi":3459},{"id":28,"text":3462,"url":28,"identifiers":3463},"10.1046\u002Fj.1440-1827.1999.00863.x",{"doi":3462},{"id":28,"text":3465,"url":28,"identifiers":3466},"10.3322\u002Fcanjclin.29.2.66",{"doi":3465},{"id":28,"text":3468,"url":28,"identifiers":3469},"10.1053\u002Fhupa.2001.21135",{"doi":3468},{"id":28,"text":3471,"url":28,"identifiers":3472},"Fisher ER, 1980, Histologic grading of breast cancer, Pathol. Annu., 15, 239",{},{"id":28,"text":3474,"url":28,"identifiers":3475},"Mueller KM, 1989, Morphologie arthroskopisch gewonnener Synovialbiopsien, Arthroskopie, 2, 94",{},{"id":3477,"createTime":3478,"updateTime":3478,"relativeEntities":3479,"slug":3480,"properties":3481,"entityType":978,"verifyStatus":26,"verifyTime":3494,"verifyNote":1261,"languages":3495,"translateLanguages":28,"viewCount":32,"primaryUrl":3496,"fullTextUrl":28,"authors":3497,"publicationType":1012,"publisherRelationship":3530,"citationCount":3583,"citationInfo":3584,"publishDate":3586,"publishYear":2918,"citationAnalyzeStatus":883,"lastCitationAnalyze":28,"indexDatabases":3587,"openAccess":28,"references":3588,"isForceReanalyzing":1242},"bc4dd981-511f-4b3c-ad23-a2bd79396f45","2024-10-05T23:59:21.644+00:00",[],"Ki67-protein-the-immaculate-deception-",{"openalex":3482,"mag":3484,"abstract":3486,"title":3488,"pm":3490,"doi":3492},{"VOID":3483},"W2001017617",{"VOID":3485},"2001017617",{"EN":3487},"\u003Cjats:p> \u003Cjats:bold>Ki67 protein: the immaculate deception?\u003C\u002Fjats:bold> \u003C\u002Fjats:p>\u003Cjats:p>This article updates our previous review of Ki67 published in \u003Cjats:italic>Histopathology\u003C\u002Fjats:italic> 10 years ago. In this period the numbers of papers published featuring this antibody has increased 10‐fold from 338 to 3489 indicating the considerable enthusiasm with which this antibody has been studied. This review attempts to provide an update on the characterization of the Ki67 protein, its function and its use as a prognostic or diagnostic tool.\u003C\u002Fjats:p>",{"EN":3489},"Ki67 protein: the immaculate deception?",{"VOID":3491},"11903593",{"VOID":3493},"10.1046\u002Fj.1365-2559.2002.01343.x","2024-10-05T23:59:21.643+00:00",[31],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1046\u002Fj.1365-2559.2002.01343.x",[3498,3515],{"id":3499,"sortIndex":32,"researcher":28,"roles":3500,"affiliations":3501,"properties":3510},"b0094d06-ad6d-48ae-b212-0b94714891cb",[],[3502],{"id":3503,"sortIndex":32,"affiliation":3504,"properties":28},"047c2318-8bf6-4804-90eb-4d6c00125dda",{"id":3503,"createTime":28,"updateTime":28,"relativeEntities":3505,"slug":28,"properties":3506,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3509,"statistic":28},[],{"title":3507},{"EN":3508},"Department of 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We have investigated the possibility of a link between these two apparently conflicting observations.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods and results:\u003C\u002Fjats:title>\u003Cjats:p>Immunohistochemistry and digital image analysis was used to examine the detailed localization of β‐amyloid\u003Cjats:sub>42\u003C\u002Fjats:sub> (Aβ42), a major component of amyloid plaques, in the entorhinal cortex and hippocampus of AD brains. Aβ42 first selectively accumulates in the perikaryon of pyramidal cells as discrete, granules that appear to be cathepsin D‐positive, suggesting that they may represent lysosomes or lysosome‐derived structures. AD brain regions abundantly populated with pyramidal neurones exhibiting excessive Aβ42 accumulations also contained evidence of neuronal lysis. Lysis of these Aβ42‐burdened neurones apparently resulted in a local, radial dispersion of their cytoplasmic contents, including Aβ42 and lysosomal enzymes, into the surrounding extracellular space. A nuclear remnant was found at the dense core of many amyloid plaques, strengthening the idea that each amyloid plaque represents the end product of a single neuronal cell lysis. The inverse relationship between the amyloid plaque density and pyramidal cell density in the AD brain regions also supports this possibility, as does the close correlation between plaque size and the size of local pyramidal cells.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions:\u003C\u002Fjats:title>\u003Cjats:p>Our findings suggest that excessive intracellular accumulation of Aβ42‐positive material in pyramidal cells can result in cell lysis, and that cell lysis is an important source of amyloid plaques and neuronal loss in AD brains.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":4355},"Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease",{"VOID":4357},"11207825",{"VOID":4359},"10.1046\u002Fj.1365-2559.2001.01082.x",[31],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1046\u002Fj.1365-2559.2001.01082.x",[4363,4382,4401,4418,4435],{"id":4364,"sortIndex":32,"researcher":28,"roles":4365,"affiliations":4366,"properties":4375},"6c04c09f-83c1-46bf-b768-a5997c23a88e",[],[4367],{"id":4368,"sortIndex":32,"affiliation":4369,"properties":28},"46afaa3d-b591-4d4a-8080-98ac3df225b5",{"id":4368,"createTime":28,"updateTime":28,"relativeEntities":4370,"slug":28,"properties":4371,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":4374,"statistic":28},[],{"title":4372},{"EN":4373},"The R W Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA. mdandrea@prius.jnj.com",[],{"orcid":4376,"title":4378,"openalex":4380},{"VOID":4377},"https:\u002F\u002Forcid.org\u002F0000-0002-2198-5123",{"EN":4379},"M. 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