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Sie stellen einen bedeutenden Risikofaktor für kardiovaskuläre Erkrankungen dar. Die Diagnostik von schlafbezogenen Atmungsstörungen kann mit einer gezielten schlafmedizinischen Anamnese und spezifischen Fragebögen beginnen und erfordert erst im zweiten Schritt einen apparativen Aufwand zur Erfassung der Sauerstoffsättigung, der Herzfrequenz, des Atmungsflusses und der Atmungsanstrengung. Die ambulant verfügbare Methodik gibt bereits gute Hinweise auf den Schweregrad der Atmungsstörung und erlaubt die Weiterleitung des Patienten zur weiterführenden Differenzialdiagnostik und\u002Foder unmittelbaren Initiierung einer adäquaten Therapie. Um eine schlafbezogene Atmungsstörung auszuschließen oder zwischen einer obstruktiven und zentralen Schlafapnoe zu differenzieren bzw. das Vorliegen weiterer Schlafstörungen zu diagnostizieren, ist eine Untersuchung im Schlaflabor mit kardiorespiratorischer Polysomnographie erforderlich. Sie ist auch bei Patienten mit Komorbiditäten indiziert. Eine angemessene und frühzeitig eingeleitete Therapie von schlafbezogenen Atmungsstörungen kann eine kardiologische Rehabilitation erheblich beschleunigen und die Prognose der Patienten verbessern.",{"EN":104},"Das Schlafapnoe-Syndrom in der Rehabilitation",{"VOID":106},"[\"10154251567038743337\"]",{"VOID":108},"10.1007\u002Fs00059-011-3541-5","PUBLICATION","VERIFIED","2024-05-03T09:23:08.001+00:00","Auto Verify","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00059-011-3541-5",[115,133,146,159],{"id":116,"sortIndex":20,"researcher":19,"roles":117,"affiliations":119,"properties":128,"displayName":130,"givenName":19,"familyName":19},"4cae38d5-bc4d-4661-948b-e9ae6c736e9a",[118],"AUTHOR",[120],{"id":121,"sortIndex":20,"affiliation":122,"properties":19},"dc783f2b-6fb5-4b3d-bbc5-7a915c3b88f5",{"id":121,"createTime":19,"updateTime":19,"relativeEntities":123,"slug":19,"properties":124,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":127,"statistic":19},[],{"title":125},{"VI":126},"Interdisziplinäres Schlafmedizinisches Zentrum, CharitéCentrum für Herz- Kreislauf- und Gefäßmedizin, Charité - Universitätsmedizin Berlin, Berlin, Deutschland",[],{"title":129,"gsAuthor":131},{"VI":130},"T. 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Somnologie 13:4–160",{},{"id":19,"text":233,"url":19,"identifiers":234},"Somers VK, White DP, Amin R et al (2008) Sleep apnea and cardiovascular disease: an American Heart Association\u002FAmerican College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing. J Am Coll Cardiol 52(8):686–717",{},{"id":236,"text":237,"url":238,"identifiers":239},"4c68646b-0035-4279-8000-0006b275d4fa","Collop NA, Anderson WM, Boehlecke B et al (2007) Clinical guidelines for the use of unattended portable monitors in the diagnosis of obstructive sleep apnea in adult patients. 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Dtsch Med Wochenschr 135:178–183",{"doi":240},false,{"id":252,"createTime":253,"updateTime":254,"relativeEntities":255,"slug":256,"properties":257,"entityType":109,"verifyStatus":110,"verifyTime":266,"verifyNote":112,"languages":19,"translateLanguages":19,"viewCount":20,"primaryUrl":267,"fullTextUrl":19,"authors":268,"publicationType":172,"publisherRelationship":286,"citationCount":84,"citationInfo":334,"publishDate":337,"publishYear":335,"citationAnalyzeStatus":225,"lastCitationAnalyze":338,"indexDatabases":339,"openAccess":19,"references":340,"isForceReanalyzing":250},"c7faf2c8-3e35-4cd8-8076-fdd2d4f094c7","2024-02-12T23:01:06.592+00:00","2026-08-15T21:57:01.654+00:00",[],"Update-periphere-arterielle-Verschlusskrankheit",{"abstract":258,"title":260,"gsPaper":262,"doi":264},{"EN":259},"Die periphere arterielle Verschlusskrankheit (PAVK) stellt aufgrund der demographischen Entwicklung eine der häufigsten Erkrankungen v. a. in westlichen Industrienationen dar. In den letzten Jahren hat sich der Trend zur überwiegend endovaskulären Revaskularisation weiter fortgesetzt. Aufgrund der hohen Erfolgsrate und geringen Komplikationsquote ist die interventionelle Therapie in den weit überwiegenden Fällen die Methode der Wahl. Die Behandlungsstrategie sollte interdisziplinär abgestimmt werden und idealerweise innerhalb von Gefäßzentren erfolgen. Das wesentliche Problem bei Interventionen ist das Auftreten von Restenosen, insbesondere bei infrapoplitealen Läsionen. Einen deutlichen Fortschritt stellen medikamentenbeschichtete Ballonkatheter dar, die in der femoropoplitealen Strombahn die Notwendigkeit für Reinterventionen drastisch reduzieren konnten. Eine sinnvolle Behandlungsalternative könnte der Einsatz von Kombinationstherapien, wie eine Plaqueentfernung mit anschließender Verwendung von medikamentenbeschichteten Ballons, sein. Hierbei sind allerdings auch ökonomische Gesichtspunkte zu beachten.",{"EN":261},"Update periphere arterielle Verschlusskrankheit",{"VOID":263},"[\"10771017299648239056\"]",{"VOID":265},"10.1007\u002Fs00059-015-4357-5","2024-05-03T10:56:44.767+00:00","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00059-015-4357-5",[269],{"id":270,"sortIndex":20,"researcher":19,"roles":271,"affiliations":272,"properties":281,"displayName":283,"givenName":19,"familyName":19},"8f81264d-bd34-4ba3-82b9-44e83cead94f",[118],[273],{"id":274,"sortIndex":20,"affiliation":275,"properties":19},"f37b3b28-b559-4e66-b13c-993d0f095730",{"id":274,"createTime":19,"updateTime":19,"relativeEntities":276,"slug":19,"properties":277,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":280,"statistic":19},[],{"title":278},{"VI":279},"SRH-Klinikum Karlsbad-Langensteinbach, Karlsbad-Langensteinbach, Deutschland",[],{"title":282,"gsAuthor":284},{"VI":283},"E. 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Eur J Vasc Endovasc Surg 38:463–474",{"doi":240},{"id":236,"text":363,"url":238,"identifiers":364},"De Backer TL, Vander Stichele R, Lehert P, Van Bortel L (2012) Naftidrofuryl for intermittent claudication. Cochrane Database Syst Rev 12:CD001368",{"doi":240},{"id":236,"text":366,"url":238,"identifiers":367},"Ruffolo AJ, Romano M, Ciapponi A (2010) Prostanoids for critical limb ischaemia. Cochrane Database Syst Rev 1:CD006544",{"doi":240},{"id":236,"text":369,"url":238,"identifiers":370},"Spronk S, Bosch JL, den Hoed PT, Veen HF et al (2009) Intermittent claudication: clinical effectiveness of endovascular revascularization versus supervised hospital-based exercise training – randomized controlled trial. Radiology 250:586–595",{"doi":240},{"id":372,"text":373,"url":374,"identifiers":375},"96d9ce12-5bd9-4b2d-9021-b83435c4b94a","Kedora J, Hohmann S, Garrett W, Munschaur C et al (2007) Randomized comparison of percutaneous Viabahn stent grafts vs prosthetic femoral–popliteal bypass in the treatment of superficial femoral arterial occlusive disease. J Vasc Surg 45:10–16","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0741521406016120",{"doi":376},"10.1016\u002Fj.jvs.2006.08.074",{"id":236,"text":378,"url":238,"identifiers":379},"Norgren L, Hiatt WR, Dormandy JA, Nehler MR et al (2007) Inter-society consensus for the management of peripheral arterial disease (TASC II). J Vasc Surg 45:S5–S67",{"doi":240},{"id":236,"text":381,"url":238,"identifiers":382},"Bosch JL, Hunink MG (1997) Meta-analysis of the results of percutaneous transluminal angioplasty and stent placement for aortoiliac occlusive disease. Radiology 204:87–96",{"doi":240},{"id":236,"text":384,"url":238,"identifiers":385},"Grenacher L, Rohde S, Ganger E, Deutsch J et al (2006) In vitro comparison of self-expanding versus balloon-expandable stents in a human ex vivo model. Cardiovasc Intervent Radiol 29:249–254",{"doi":240},{"id":236,"text":387,"url":238,"identifiers":388},"Schillinger M, Sabeti S, Dick P, Amighi J et al (2007) Sustained benefit at 2 years of primary femoropopliteal stenting compared with balloon angioplasty with optional stenting. Circulation 115:2745–2749",{"doi":240},{"id":236,"text":390,"url":238,"identifiers":391},"Dick P, Wallner H, Sabeti S, Loewe C et al (2009) Balloon angioplasty versus stenting with nitinol stents in intermediate length superficial femoral artery lesions. Catheter Cardiovasc Interv 74:1090–1095",{"doi":240},{"id":19,"text":393,"url":19,"identifiers":394},"Rastan A, Krankenberg H, Baumgartner I, Blessing E et al (2013) Stent placement versus balloon angioplasty for the treatment of obstructive lesions of the popliteal artery: a prospective, multicenter, randomized trial. Circulation 127:2535–2541",{},{"id":19,"text":396,"url":19,"identifiers":397},"Rastan A, Krankenberg H, Baumgartner I, Blessing E et al (2015) Stent placement vs. balloon angioplasty for popliteal artery treatment: two-year results of a prospective, multicenter, randomized trial. J Endovasc Ther 22:22–27",{},{"id":236,"text":399,"url":238,"identifiers":400},"Scheinert D, Grummt L, Piorkowski M, Sax J et al (2011) A novel self-expanding interwoven nitinol stent for complex femoropopliteal lesions: 24-month results of the SUPERA SFA registry. J Endovasc Ther 18:745–752",{"doi":240},{"id":19,"text":402,"url":19,"identifiers":403},"Scheinert D, Werner M, Scheinert S, Paetzold A et al (2013) Treatment of complex atherosclerotic popliteal artery disease with a new self-expanding interwoven nitinol stent: 12-month results of the Leipzig SUPERA popliteal artery stent registry. JACC Cardiovasc Interv 6:65–71",{},{"id":19,"text":405,"url":19,"identifiers":406},"Garcia L, Jaff MR, Metzger C, Sedillo G et al (2015) Wire-Interwoven Nitinol Stent outcome in the superficial femoral and proximal popliteal arteries: twelve-month results of the SUPERB trial. Circ Cardiovasc Interv 8:pii:e000937",{},{"id":236,"text":408,"url":238,"identifiers":409},"Duda SH, Bosiers M, Lammer J, Scheinert D et al (2006) Drug-eluting and bare nitinol stents for the treatment of atherosclerotic lesions in the superficial femoral artery: long-term results from the SIROCCO trial. J Endovasc Ther 13:701–710",{"doi":240},{"id":19,"text":411,"url":19,"identifiers":412},"Dake MD, Ansel GM, Jaff MR, Ohki T et al (2011) Paclitaxel-eluting stents show superiority to balloon angioplasty and bare metal stents in femoropopliteal disease: twelve-month Zilver PTX randomized study results. Circ Cardiovasc Interv 4:495–504",{},{"id":19,"text":414,"url":19,"identifiers":415},"Dake MD, Ansel GM, Jaff MR, Ohki T et al (2013) Sustained safety and effectiveness of paclitaxel-eluting stents for femoropopliteal lesions: 2-year follow-up from the Zilver PTX randomized and single-arm clinical studies. J Am Coll Cardiol 61:2417–2427",{},{"id":236,"text":417,"url":238,"identifiers":418},"Tepe G, Zeller T, Albrecht T, Heller S et al (2008) Local delivery of paclitaxel to inhibit restenosis during angioplasty of the leg. N Engl J Med 358:689–699",{"doi":240},{"id":19,"text":420,"url":19,"identifiers":421},"Werk M, Langner S, Reinkensmeier B, Boettcher HF et al (2008) Inhibition of restenosis in femoropopliteal arteries: paclitaxel-coated versus uncoated balloon: femoral paclitaxel randomized pilot trial. Circulation 118:1358–1365",{},{"id":19,"text":423,"url":424,"identifiers":425},"Scheinert D (2010) LEVANT I Trial 6-month results – A comparison of the Moxy™ drug coated balloon catheter vs standard PTA for femoropopliteal disease. Transcatheter Cardiovascular Therapeutics Congress, 2010 September, Washington, DC 2010; Oral presentation. http:\u002F\u002Fwww.tctmd.com\u002Fshow.aspx?id=102034","http:\u002F\u002Fwww.tctmd.com\u002Fshow.aspx?id=102034",{},{"id":19,"text":427,"url":428,"identifiers":429},"Werk M, Albrecht T, Meyer DR, Stiepani H et al (2011) The PACIFIER trial. A randomized multicenter trial evaluating prevention of restenosis with paclitaxel-coated PTA balloon catheters in stenosis or occlusion of femoropopliteal arteries. Cardiovascular and Interventional Radiological Society of Europe Congress, 2011 September, Munich 2011; Oral presentation. http:\u002F\u002Fwww.esir.org\u002Fcslide\u002Flibrary\u002Fesir\u002Fmylibrary\u002Fauthors\u002FW\u002FM.+Werk","http:\u002F\u002Fwww.esir.org\u002Fcslide\u002Flibrary\u002Fesir\u002Fmylibrary\u002Fauthors\u002FW\u002FM.+Werk",{},{"id":236,"text":431,"url":238,"identifiers":432},"Rosenfield K, Jaff MR, White CJ, Rocha-Singh K et al (2015) Trial of a paclitaxel-coated balloon for femoropopliteal artery disease. N Engl J Med 373:145–153",{"doi":240},{"id":19,"text":434,"url":19,"identifiers":435},"Tepe G, Laird J, Schneider P, Brodmann M et al (2015) Drug-coated balloon versus standard percutaneous transluminal angioplasty for the treatment of superficial femoral and popliteal peripheral artery disease. 12-month results from the IN.PACT SFA randomized trial. Circulation 131:495–502",{},{"id":19,"text":437,"url":19,"identifiers":438},"Cassese S, Byrne RA, Ott I, Ndrepepa G et al (2012) Paclitaxel-coated versus uncoated balloon angioplasty reduces target lesion revascularization in patients with femoropopliteal arterial disease: a meta-analysis of randomized trials. Circ Cardiovasc Interv 5:582–589",{},{"id":19,"text":440,"url":19,"identifiers":441},"Tepe G (2011) 5 year thunder follow up: patients with pad treated with uncoated versus paccocath paclitaxel coated balloons. JACC 58(Suppl B):B151–B151",{},{"id":19,"text":443,"url":19,"identifiers":444},"Liistro F, Grotti S, Porto I, Angioli P et al (2013) Drug-eluting balloon in peripheral intervention for the superficial femoral artery: the DEBATE-SFA randomized trial (drug eluting balloon in peripheral intervention for the superficial femoral artery). JACC Cardiovasc Interv 6:1295–1302",{},{"id":236,"text":446,"url":238,"identifiers":447},"Diehm N, Schneider H (2013) Cost-effectiveness analysis of paclitaxel-coated balloons for endovascular therapy of femoropopliteal arterial obstructions. J Endovasc Ther 20:819–825",{"doi":240},{"id":19,"text":449,"url":19,"identifiers":450},"Mc Kinsey JF, Zeller T, Rocha-Singh KH, Jaff MR et al (2014) Lower extremity revascularization using directional atherectomy: 12-month prospective results of the DEFINITIVE LE study. JACC Cardiovasc Interv 7:923–933",{},{"id":236,"text":452,"url":238,"identifiers":453},"McKinsey JF, Goldstein L, Khan HU, Graham A et al (2008) Novel treatment of patients with lower extremity ischemia: use of percutaneous atherectomy in 579 lesions. Ann Surg 248:519–528",{"doi":240},{"id":236,"text":455,"url":238,"identifiers":456},"Zeller T, Rastan A, Sixt S, Schwarzwälder U et al (2006) Long-term results after directional atherectomy of femoro-popliteal lesions. J Am Coll Cardiol 48:1573–1578",{"doi":240},{"id":19,"text":458,"url":459,"identifiers":460},"Garcia LA, Jaff MR, Rocha-Singh KJ, Zeller T et al (2015) A comparison of clinical outcomes for diabetic and nondiabetic patients following directional atherectomy in the DEFINITIVE LE Claudicant cohort. J Endovasc Ther. pii:1526602815599550. (Epub ahead of print) doi:10.1177\u002F1526602815599550","https:\u002F\u002Fdoi.org\u002F10.1177\u002F1526602815599550",{"mag":461,"openalex":462,"pm":463,"doi":464},"2303882528","W2303882528","26250748","10.1177\u002F1526602815599550",{"id":466,"text":467,"url":468,"identifiers":469},"a34c8f82-9072-42a8-b8d7-21830ca5a48e","Sixt S, Carpio Cancino OG, Treszl A, Beschorner U et al (2013) Drug-coated balloon angioplasty after directional atherectomy improves outcome in restenotic femoropopliteal arteries. J Vasc Surg 58:682–686","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0741521413002474",{"doi":470},"10.1016\u002Fj.jvs.2013.02.019",{"id":19,"text":472,"url":19,"identifiers":473},"Lammer J, Zeller T, Hausegger KA, Schaefer PJ et al (2013) Heparin-bonded covered stents versus bare-metal stents for complex femoropopliteal artery lesions: the randomized VIASTAR trial (Viabahn endoprosthesis with PROPATEN bioactive surface [VIA] versus bare nitinol stent in the treatment of long lesions in superficial femoral artery occlusive disease). J Am Coll Cardiol 62:1320–1327",{},{"id":19,"text":475,"url":19,"identifiers":476},"Serruys PW, Onuma Y, Dudek D, Smits PC et al (2011) Evaluation of the second generation of a bioresorbable everolimus-eluting vascular scaffold for the treatment of de novo coronary artery stenosis: 12-month clinical and imaging outcomes. J Am Coll Cardiol 58:1578–1588",{},{"id":478,"text":479,"url":480,"identifiers":481},"2fa435e3-2ae4-4118-9992-8396b1781f94","Adam DJ, Beard JD, Cleveland T, Bell J et al (2005) Bypass versus angioplasty in severe ischaemia of the leg (BASIL): multicentre, randomised controlled trial. Lancet 366:1925–1934","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0140673605677045",{"doi":482},"10.1016\u002FS0140-6736(05)67704-5",{"id":236,"text":484,"url":238,"identifiers":485},"Iida O, Nanto S, Uematsu M, Ikeoka K et al (2010) Importance of the angiosome concept for endovascular therapy in patients with critical limb ischemia. Catheter Cardiovasc Interv 75:830–836",{"doi":240},{"id":236,"text":487,"url":238,"identifiers":488},"Fusaro M, Cassese S, Ndrepepa G, Tepe G et al (2013) Drug-eluting stents for revascularization of infrapopliteal arteries: updated meta-analysis of randomized trials. JACC Cardiovasc Interv 6:1284–1293",{"doi":240},{"id":19,"text":490,"url":19,"identifiers":491},"Schmidt A, Piorkowski M, Werner M, Ulrich M et al (2011) First experience with drug-eluting balloons in infrapopliteal arteries: restenosis rate and clinical outcome. J Am Coll Cardiol 58:1105–1109",{},{"id":236,"text":493,"url":238,"identifiers":494},"Zeller T, Baumgartner I, Scheinert D, Brodmann M et al (2014) Drug-eluting balloon versus standard balloon angioplasty for intrapopliteal arterial revascularization in critical limb ischemia: 12-month results from IN.PACT DEEP randomized trial. J Am Coll Cardiol 64:1568–1576",{"doi":240},{"id":236,"text":496,"url":238,"identifiers":497},"Baigent C, Blackwell L, Collins R, Emberson J et al (2009) Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomized trials. Lancet 373:1849–1860",{"doi":240},{"id":236,"text":499,"url":238,"identifiers":500},"CAPRIE Steering Committee (1996) A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 348:1329–1339",{"doi":240},{"id":236,"text":502,"url":238,"identifiers":503},"Brown J, Lethaby A, Maxwell H, Wawrzyniak AJ et al (2008) Antiplatelet agents for preventing thrombosis after peripheral bypass surgery. Cochrane Database Syst Rev 4:CD000535",{"doi":240},{"id":505,"text":506,"url":507,"identifiers":508},"c4e97b2c-752d-4c07-92f0-d8f3cd31b03a","No authors (2000) Efficacy of oral anticoagulants compared with aspirin after infrainguinal bypass surgery (The Dutch Bypass Oral Anticoagulants or Aspirin Study): a randomised trial. Lancet 355:346–351","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0140673699071998",{"doi":509},"10.1016\u002Fs0140-6736(99)07199-8",{"id":19,"text":511,"url":19,"identifiers":512},"Johnson WC, Williford WO, Department of Veterans Affairs Cooperative Study #362 (2002) Benefits, morbidity, and mortality associated with long-term administration of oral anticoagulant therapy to patients with peripheral arterial bypass procedures: a prospective randomized study. J Vasc Surg 35:413–421",{},{"id":236,"text":514,"url":238,"identifiers":515},"Sarac TP, Huber TS, Back MR, Ozaki CK et al (1998) Warfarin improves the outcome of infrainguinal vein bypass grafting at high risk for failure. J Vasc Surg 28:446–457",{"doi":240},{"id":517,"createTime":518,"updateTime":519,"relativeEntities":520,"slug":521,"properties":522,"entityType":109,"verifyStatus":110,"verifyTime":531,"verifyNote":112,"languages":19,"translateLanguages":19,"viewCount":20,"primaryUrl":532,"fullTextUrl":19,"authors":533,"publicationType":172,"publisherRelationship":619,"citationCount":20,"citationInfo":667,"publishDate":670,"publishYear":668,"citationAnalyzeStatus":671,"lastCitationAnalyze":672,"indexDatabases":673,"openAccess":19,"references":674,"isForceReanalyzing":250},"711691ae-b3bb-4d03-8060-d02a4b2e77fa","2024-01-13T19:59:20.609+00:00","2026-07-30T07:04:57.626+00:00",[],"Causes-and-predictors-of-readmission-after-transcatheter-aortic-valve-implantation",{"abstract":523,"title":525,"gsPaper":527,"doi":529},{"EN":524},"Since readmission rate is an important clinical index to determine the quality of inpatient care and hospital performance, the aim of this study was to explain the causes and predictors of readmission following transcatheter aortic valve implantation (TAVI) at short-term and mid-term follow-up. A systematic review and meta-analysis of all published articles from Embase, Pubmed\u002FMEDLINE, and Ovid was carried out. In all, 10 studies including 52,702 patients were identified. The pooled estimate for the overall event rate was 0.15, and cardiovascular causes were the main reason for 30-day readmission (0.42, 95% confidence interval [CI]: 0.39–0.45). In addition, the pooled incidence of 1‑year readmission was 0.31, and cardiovascular events were still the main cause (0.41, 95% CI: 0.33–0.48). Patients with major and life-threatening bleeding, new permanent pacemaker implantation, and clinical heart failure were associated with a high risk for early readmission after TAVI. Moreover, an advanced (≥3) New York Heart Association classification, acute kidney injury, paravalvular leak, mitral regurgitation (≥ moderate), and major bleeding predicted unfavorable outcome to 1‑year readmission. Female gender and transfemoral TAVI was associated with a lower risk for unplanned rehospitalization. This meta-analysis found cardiovascular factors to be the main causes for both 30-day and 1‑year rehospitalization. Heart failure represented the most common cardiovascular event at both short-term and mid-term follow-up. Several baseline characteristics and procedure-related factors were deemed unfavorable predictors of readmission. Importantly, transfemoral access and female gender were associated with a lower risk of readmission.",{"EN":526},"Causes and predictors of readmission after transcatheter aortic valve implantation",{"VOID":528},"[\"6319837214839420974\",\"7250253020773850358\"]",{"VOID":530},"10.1007\u002Fs00059-019-04870-6","2024-05-06T05:22:43.859+00:00","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00059-019-04870-6",[534,549,564,579,592,606],{"id":535,"sortIndex":20,"researcher":19,"roles":536,"affiliations":537,"properties":546,"displayName":548,"givenName":19,"familyName":19},"5de92177-0181-4c00-b713-760de1a49030",[118],[538],{"id":539,"sortIndex":20,"affiliation":540,"properties":19},"86b1966d-8353-4b6d-8380-b65006519b1b",{"id":539,"createTime":19,"updateTime":19,"relativeEntities":541,"slug":19,"properties":542,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":545,"statistic":19},[],{"title":543},{"VI":544},"Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China",[],{"title":547},{"VI":548},"Yi-ming Li",{"id":550,"sortIndex":83,"researcher":19,"roles":551,"affiliations":552,"properties":561,"displayName":563,"givenName":19,"familyName":19},"eb1ccc54-4273-418b-a313-6976741dd488",[118],[553],{"id":554,"sortIndex":20,"affiliation":555,"properties":19},"900627f1-0e96-4a34-84e8-5d5d6f8b8649",{"id":554,"createTime":19,"updateTime":19,"relativeEntities":556,"slug":19,"properties":557,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":560,"statistic":19},[],{"title":558},{"VI":559},"Zhejiang Provincial People’s Hospital, Hangzhou, China",[],{"title":562},{"VI":563},"Fu-yang Mei",{"id":565,"sortIndex":85,"researcher":19,"roles":566,"affiliations":567,"properties":576,"displayName":578,"givenName":19,"familyName":19},"b51cceba-c9cd-47b1-8b7e-b260ef636216",[118],[568],{"id":569,"sortIndex":20,"affiliation":570,"properties":19},"7efcd75f-a981-4b6e-8bd8-02abc1616c42",{"id":569,"createTime":19,"updateTime":19,"relativeEntities":571,"slug":19,"properties":572,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":575,"statistic":19},[],{"title":573},{"VI":574},"West China School of Medicine, Sichuan University, Chengdu, China",[],{"title":577},{"VI":578},"Yi-jun 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JAMA Cardiol 2(11):1208–1216. https:\u002F\u002Fdoi.org\u002F10.1001\u002Fjamacardio.2017.3425","http:\u002F\u002Fcardiology.jamanetwork.com\u002Farticle.aspx?doi=10.1001\u002Fjamacardio.2017.3425",{"doi":945},"10.1001\u002Fjamacardio.2017.3425",{"id":947,"text":948,"url":949,"identifiers":950},"735939e3-5a42-4cc2-bc5e-53c2e5b3acb0","Abdelghani M, Mankerious N, Allali A et al (2018) Bioprosthetic valve performance after transcatheter aortic valve replacement with self-expanding versus balloon-expandable valves in large versus small aortic valve annuli: insights from the CHOICE Trial and the CHOICE-Extend Registry. JACC Cardiovasc Interv 11(24):2507–2518. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jcin.2018.07.050","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS1936879818316650",{"doi":951},"10.1016\u002Fj.jcin.2018.07.050",{"id":953,"text":954,"url":955,"identifiers":956},"98d31877-c73c-4a20-92ab-88c0d59f08ef","Schulz E, Jabs A, Gori T et al (2016) Transcatheter aortic valve implantation with the new-generation Evolut R: comparison with CoreValve(R) in a single center cohort. 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J Am Coll Cardiol 63(24):2643–2658. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jacc.2014.02.573","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS0735109714015587",{"doi":963},"10.1016\u002Fj.jacc.2014.02.573",{"id":965,"text":966,"url":967,"identifiers":968},"28c69b8a-18f8-4fa7-a1ae-a1ba47ad5249","Toggweiler S, Boone RH, Rodes-Cabau J et al (2012) Transcatheter aortic valve replacement: outcomes of patients with moderate or severe mitral regurgitation. J Am Coll Cardiol 59(23):2068–2074. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jacc.2012.02.020","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0735109712009230",{"doi":969},"10.1016\u002Fj.jacc.2012.02.020",{"id":19,"text":971,"url":972,"identifiers":973},"O’Sullivan CJ, Wenaweser P, Ceylan O et al (2015) Effect of pulmonary hypertension hemodynamic presentation on clinical outcomes in patients with severe symptomatic aortic valve stenosis undergoing transcatheter aortic valve implantation: insights from the new proposed pulmonary hypertension classification. 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Arterioscler Thromb Vasc Biol 26(8):1721–1728. https:\u002F\u002Fdoi.org\u002F10.1161\u002F01.ATV.0000227513.13697.ac","https:\u002F\u002Fdoi.org\u002F10.1161\u002F01.ATV.0000227513.13697.ac",{"doi":985},"10.1161\u002F01.ATV.0000227513.13697.ac",{"id":987,"text":988,"url":989,"identifiers":990},"64690cca-a9dd-400e-8995-c3f1b7ecabef","Zhao ZG, Liao YB, Peng Y et al (2013) Sex-related differences in outcomes after transcatheter aortic valve implantation: a systematic review and meta-analysis. Circ Cardiovasc Interv 6(5):543–551. https:\u002F\u002Fdoi.org\u002F10.1161\u002Fcircinterventions.113.000529","https:\u002F\u002Fwww.ahajournals.org\u002Fdoi\u002F10.1161\u002FCIRCINTERVENTIONS.113.000529",{"doi":991},"10.1161\u002Fcircinterventions.113.000529",{"id":993,"createTime":994,"updateTime":995,"relativeEntities":996,"slug":997,"properties":998,"entityType":109,"verifyStatus":110,"verifyTime":1007,"verifyNote":112,"languages":19,"translateLanguages":19,"viewCount":20,"primaryUrl":1008,"fullTextUrl":1009,"authors":1010,"publicationType":172,"publisherRelationship":1151,"citationCount":1200,"citationInfo":1201,"publishDate":1203,"publishYear":335,"citationAnalyzeStatus":671,"lastCitationAnalyze":995,"indexDatabases":1204,"openAccess":19,"references":1205,"isForceReanalyzing":250},"26224138-30e8-4b56-802d-cc338b71d175","2024-01-21T00:19:08.682+00:00","2026-07-29T08:48:49.040+00:00",[],"Association-between-high-sensitivity-troponin-T-left-ventricular-hypertrophy-and-myocardial-performance-index",{"abstract":999,"title":1001,"gsPaper":1003,"doi":1005},{"EN":1000},"The prognostic importance of high-sensitivity cardiac troponin T (hs-cTnT) has recently been reported in patients with heart failure. The myocardial performance index (MPI), which combines parameters of both systolic and diastolic ventricular function, provides a better marker of left ventricular dysfunction in hypertensive patients with preserved left ventricular ejection fraction (LVEF). We aimed to investigate the relationship between hs-cTnT and tissue Doppler-derived MPI in newly diagnosed hypertensive patients with preserved LVEF. We studied 306 patients with newly diagnosed hypertension. The patients were divided into two groups according to their median MPI values: MPIlo and MPIhigh groups. The MPI was calculated from the pulsed-wave Doppler recordings. Left ventricular mass index (LVMI) was determined according to the Devereux formula. hs-cTnT, uric acid, and high-sensitivity C-reactive protein (hs-CRP) levels were measured in all patients. Hs-cTnT, hs-CRP, and uric acid levels were higher in the MPIhigh group compared with the MPIlow group (p < 0.05, for all). The LVMI values in the MPIhigh group were higher than in the MPIlow group (p < 0.05). MPI was independently associated with age, uric acid, hs-cTnT, and LVMI in multivariate analysis. Multivariate logistic regression analysis showed that MPI and LVMI were independent predictors of high hs-cTnT level in newly diagnosed hypertensive patients with preserved LVEF. Hs-cTnT was independently associated with LV dysfunction and LV hypertrophy assessed with MPI in newly diagnosed hypertensive patients.",{"EN":1002},"Association between high-sensitivity troponin T, left ventricular hypertrophy, and myocardial performance 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Herz. \n                    https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00059-017-4633-7",{"doi":1547},"10.1007\u002Fs00059-017-4633-7",{"id":19,"text":1549,"url":19,"identifiers":1550},"Paraskevaidis IA, Farmakis D, Papadopoulos C, Ikonomidis I, Parissis J, Rigopoulos A et al (2009) Two-dimensional strain analysis in patients with hypertrophic cardiomyopathy and normal systolic function: a 12-month follow-up study. Am Heart J 158:444–450",{"doi":1551},"10.1016\u002Fj.ahj.2009.06.013",{"id":19,"text":1553,"url":19,"identifiers":1554},"Haland TF, Almaas VM, Hasselberg NE, Saberniak J, Leren IS, Hopp E et al (2016) Strain echocardiography is related to fibrosis and ventricular arrhythmias in hypertrophic cardiomyopathy. Eur Heart J Cardiovasc Imaging 17(6):613–621. \n                    https:\u002F\u002Fdoi.org\u002F10.1093\u002Fehjci\u002Fjew005",{"doi":1555},"10.1093\u002Fehjci\u002Fjew005",{"id":19,"text":1557,"url":19,"identifiers":1558},"Zhang HJ, Wang H, Sun T, Lu MJ, Xu N, Wu WC et al (2014) Assessment of left ventricular twist mechanics by speckle tracking echocardiography reveals association between LV twist and myocardial fibrosis in patients with hypertrophic cardiomyopathy. Int J Cardiovasc Imaging 30(8):1539–1548. \n                    https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs10554-014-0509-6",{"doi":1559},"10.1007\u002Fs10554-014-0509-6",{"id":19,"text":1561,"url":19,"identifiers":1562},"Russel IK, Brouwer WP, Germans T, Knaapen P, Marcus TJ, van der Velden J et al (2011) Increased left ventricular torsion in hypertrophic cardiomyopathy mutation carriers with normal wall thickness. J Cardiovasc Magn Reson 13:3",{"doi":1563},"10.1186\u002F1532-429X-13-3",{"id":19,"text":1565,"url":19,"identifiers":1566},"Kauer F, van Dalen BM, Michels M, Schinkel AF, Vletter WB, van Slegtenhorst M et al (2017) Delayed and decreased LV untwist and unstrain rate in mutation carriers for hypertrophic cardiomyopathy. Eur Heart J Cardiovasc Imaging 18:383–389",{},{"id":19,"text":1568,"url":19,"identifiers":1569},"Blanchard E, Seidman C, Seidman JG, LeWinter M, Maughan D (1999) Altered crossbridge kinetics in the alphaMHC403\u002F+ mouse model of familial hypertrophic cardiomyopathy. Circ Res 84:475–483",{"doi":1570},"10.1161\u002F01.RES.84.4.475",{"id":19,"text":1572,"url":19,"identifiers":1573},"Landstrom AP, Dobrev D, Wehrens XHT (2017) Calcium signaling and cardiac arrhythmias. Circ Res 120:1969–1993",{"doi":1574},"10.1161\u002FCIRCRESAHA.117.310083",{"id":19,"text":1576,"url":19,"identifiers":1577},"Elliott PM, Poloniecki J, Dickie S, Sharma S, Monserrat L, Varnava A et al (2000) Sudden death in hypertrophic cardiomyopathy: identification of high risk patients. J Am Coll Cardiol 36:2212–2218",{"doi":1578},"10.1016\u002FS0735-1097(00)01003-2",{"id":19,"text":1580,"url":19,"identifiers":1581},"Westphal JG, Rigopoulos AG, Bakogiannis C, Ludwig SE, Mavrogeni S, Bigalke B et al (2017) The MOGE(S) classification for cardiomyopathies: current status and future outlook. Heart Fail Rev 22(6):743–752. \n                    https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs10741-017-9641-4",{"doi":1582},"10.1007\u002Fs10741-017-9641-4",{"id":1584,"createTime":1585,"updateTime":1586,"relativeEntities":1587,"slug":1588,"properties":1589,"entityType":109,"verifyStatus":110,"verifyTime":1600,"verifyNote":112,"languages":19,"translateLanguages":19,"viewCount":20,"primaryUrl":1601,"fullTextUrl":19,"authors":1602,"publicationType":172,"publisherRelationship":1696,"citationCount":1744,"citationInfo":1745,"publishDate":1748,"publishYear":1746,"citationAnalyzeStatus":18,"lastCitationAnalyze":1749,"indexDatabases":1750,"openAccess":19,"references":19,"isForceReanalyzing":250},"82b4165c-c2c3-4eff-8140-1ecb9bd72051","2024-01-21T06:50:40.624+00:00","2026-07-23T20:52:23.163+00:00",[],"Exercise-Capacity-Is-the-Most-Powerful-Predictor-of-2-Year-Mortality-in-Patients-with-Left-Ventricular-Systolic-Dysfunction",{"abstract":1590,"title":1592,"gsPaper":1594,"references":1596,"doi":1598},{"EN":1591},"There are few data about predictors of cardiovascular mortality and rehospitalization rate in patients with left ventricular systolic dysfunction (LVSD) after myocardial revascularization and optimization of pharmacological treatment. 1,346 consecutive patients with left ventricular ejection fraction (LVEF) \u003C 45% (64 ± 10 years, 73% male, LVEF 36.3% ± 8%), who were referred for inpatient cardiac rehabilitation, were followed prospectively for 731 ± 215 days in a unicentric prospective longitudinal registry. Multivariate logistic regression Cox models were used to analyze demographic, echocardiographic and exercise variables in order to determine independent predictors of cardiovascular mortality and rehospitalization. LVEF failed to show prognostic power (hazard ratio [HR] 0.99 [95% confidence interval, CI, 0.94–1.03]; p = not significant), whereas moderate to severe mitral regurgitation (HR, 5.71 [95% CI 1.75–18.6]; p = 0.004) and atrial fibrillation (HR 1.67 [95% CI 1.15–2.44]; p = 0.008) were associated with a poorer prognosis. In an optimized multivariate model, 6-min walk test (HR 0.93 [95% CI 0.86–1.00] per 50 m; p = 0.049) and symptom-limited maximum exercise capacity test (HR 0.83 [95% CI 0.76–0.91] per 10 W; p \u003C 0.001) as well as female gender (HR 0.58 [95% CI 0.39–0.84]; p = 0.005) were strong predictors for reduced overall mortality. In patients with LVSD, independently of LVEF, traditional prognostic factors including atrial fibrillation or mitral regurgitation predict poorer survival, whereas symptom-limited exercise capacity and walking distance performed in 6-min walk test were highly predictive for a good prognosis.",{"EN":1593},"Exercise Capacity Is the Most Powerful Predictor of 2-Year Mortality in Patients with Left Ventricular Systolic Dysfunction",{"VOID":1595},"[\"2762124064764434479\"]",{"VOID":1597},"Kerzner R, Gage BF, Freedland KE, et al. Predictors of mortality in younger and older patients with heart failure and preserved or reduced left ventricular ejection fraction. Am Heart J 2003;146:286–290.\nPitt B, Remme W, Zannad F, et al., Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003;348:1309–1321.\nYoung JB, Dunlap ME, Pfeffer MA, et al. Mortality and morbidity reduction with candesartan in patients with chronic heart failure and left ventricular systolic dysfunction: results of the CHARM low-left ventricular ejection fraction trials. Circulation 2004;110:2618–2626.\nZipes DP, Camm AJ, Borggrefe M, et al. ACC\u002FAHA\u002FESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology\u002FAmerican Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines Writing (Committee to Develop Guidelines for Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). J Am Coll Cardiol 2006;48:247–346.\nStewart S, MacIntyre K, Hole DJ, et al. More “malignant” than cancer? Five-year survival following a first admission for heart failure. Eur J Heart Fail 2001;3:315–322.\nCygankiewicz I, Zareba W, Vazquez R, et al. Heart rate turbulence predicts all-cause mortality and sudden death in congestive heart failure patients. Heart Rhythm 2008;5:1095–1102.\nde Sousa MR, Morillo CA, Rabelo FT, et al. Non-sustained ventricular tachycardia as a predictor of sudden cardiac death in patients with left ventricular dysfunction: a meta-analysis. Eur J Heart Fail 2008;10:1007–1014.\nLaukkanen JA, Kurl S, Salonen R, et al. The predictive value of cardiorespiratory fitness for cardiovascular events in men with various risk profiles: a prospective population-based cohort study. Eur Heart J 2004;25:1428–1437.\nFeigenbaum H. Echocardiographic evaluation of cardiac chambers. In: Bussy RK, ed. Echocardiography, 5th edn. Philadelphia: Lea & Febiger, 1994:138–140.\nGuyatt GH, Sullivan MJ, Thompson PJ, et al. The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure. CMAJ 1985;132:919–923.\nRemme WJ. The treatment of heart failure. Task Force of the Working Group on Heart Failure of the ESC. Eur Heart J 1997;18:736–753.\nMolenberghs G, Kenward MG. Missing data in clinical studies. Chichester: Wiley, 2007.\nReibis R, Dovifat C, Dissmann R, et al. Implementation of evidence based therapy in patients with systolic heart failure from 1998–2000. Clin Res Cardiol 2006;95:154–156.\nCorell P, Gustafsson F, Schou M, et al. Prevalence and prognostic significance of atrial fibrillation in outpatients with heart failure due to left ventricular systolic dysfunction. Eur J Heart Fail 2007;9:258–265.\nPocock SJ, Wang D, Pfeffer MA, et al. Predictors of mortality and morbidity in patients with chronic heart failure. Eur Heart J 2006;27:65–75.\nOlsson LG, Swedberg K, Ducharme A, et al. Atrial fibrillation and risk of clinical events in chronic heart failure with and without left ventricular systolic dysfunction: results from the Candesartan in Heart failure-Assessment of Reduction in Mortality and morbidity (CHARM) program. J Am Coll Cardiol 2006;47:1997–2004.\nMiyasaka Y, Barnes ME, Bailey KR, et al. Mortality trends in patients diagnosed with first atrial fibrillation: a 21-year community-based study. J Am Coll Cardiol 2007;49:986–992.\nAmigoni M, Meris A, Thune JJ, et al. Mitral regurgitation in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both: prognostic significance and relation to ventricular size and function. Eur Heart J 2007;28:326–333.\nHillis GS, Møller JE, Pellikka PA, et al. Prognostic significance of echocardiographically defined mitral regurgitation early after acute myocardial infarction. Am Heart J 2 2005;150:1268–1275.\nPastorius CA, Henry TD, Harris KM. Long-term outcomes of patients with mitral regurgitation undergoing percutaneous coronary intervention. Am J Cardiol 2007;100:1218–1223.\nde Groote P, Lamblin N, Mouquet F, et al. No gender survival difference in a population of patients with chronic heart failure related to left ventricular systolic dysfunction and receiving optimal medical therapy. Arch Cardiovasc Dis 2008;101:242–248.\nDe Feo S, Opasich C. Comparison of the outcome in men and women with chronic heart failure. Ital Heart J 2003; 4:511–513.\nSolomon SD, Anavekar N, Skali H, et al., Candesartan in Heart Failure Reduction in Mortality (CHARM) Investigators. Influence of ejection fraction on cardiovascular outcomes in a broad spectrum of heart failure patients. Circulation 2005;112:3738–3744.\nBittner V, Weiner DH, Yusuf S, et al. Prediction of mortality and morbidity with a 6-minute walk test in patients with left ventricular dysfunction. SOLVD Investigators. JAMA 1993;270:1702–1707.\nBittner V. Determining prognosis in congestive heart failure: role of the 6-minute walk test. Am Heart J 1999;138:593–596.\nPassantino A, Lagioia R, Mastropasqua F, et al. Short-term change in distance walked in 6 min is an indicator of outcome in patients with chronic heart failure in clinical practice. J Am Coll Cardiol 2006;48:99–105.\nShah MR, Hasselblad V, Gheorghiade M, et al. Prognostic usefulness of the six-minute walk in patients with advanced congestive heart failure secondary to ischemic or nonischemic cardiomyopathy. Am J Cardiol 2001;88:987–993.\nRoul G, Germain P, Bareiss P. Does the 6-minute walk test predict the prognosis in patients with NYHA class II or III chronic heart failure? Am Heart J 1998;136:449–445.\nArena R, Myers J, Aslam SS, et al. Peak VO2 and VE\u002FVCO2 slope in patients with heart failure: a prognostic comparison. Am Heart J 2004;147:354–360.\nArena R, Myers J, Guazzi M. The clinical and research applications of aerobic capacity and ventilatory efficiency in heart failure: an evidence-based review. Heart Fail Rev 2008;13:245–269.\nGuazzi M, Myers J, Abella J, et al. The added prognostic value of ventilatory efficiency to the Weber classification system in patients with heart failure. Int J Cardiol 2008;129:86–92.\nGuazzi M, Myers J, Arena R. Cardiopulmonary exercise testing in the clinical and prognostic assessment of diastolic heart failure. J Am Coll Cardiol 2005;46:1883–1890.\nSharma R, Anker SD. The 6-minute walk test and prognosis in chronic heart failure — the available evidence. Eur Heart J 2001;22:445–448.\nCahalin LP, Mathier MA, Semigran MJ, et al. The six-minute walk test predicts peak oxygen uptake and survival in patients with advanced heart failure. Chest 1996;110:325–332.\nZugck C, Kruger C, Durr S, et al. Is the 6-minute walk test a reliable substitute for peak oxygen uptake in patients with dilated cardiomyopathy? Eur Heart J 2000;21:540–549.\nEnright PL, McBurnie MA, Bittner V, et al. The 6-min walk test: a quick measure of functional status in elderly adults. Chest 2003;123:387–398.\nFaggiano P, D'Aloia A, Gualeni A, et al. The 6 minute walking test in chronic heart failure: indications, interpretation and limitations from a review of the literature. Eur J Heart Fail 2004;6:687–691.\nHsich E, Gorodeski EZ, Starling RC et al. Importance of treadmill exercise time as an initial prognostic screening tool in patients with systolic left ventricular dysfunction. Circulation 2009;119:3189–3197.\nIngle L, Shelton RJ, Rigby AS, et al. The reproducibility and sensitivity of the 6-min walk test in elderly patients with chronic heart failure. Eur Heart J 2005;26:1742–1751.\nDemers C, McKelvie RS, Negassa A, et al., RESOLVD Pilot Study Investigators. Reliability, validity, and responsiveness of the six-minute walk test in patients with heart failure. Am Heart J 2001;142:698–703.\nFrankenstein L, Remppis A, Graham J, et al. Gender and age related predictive value of walk test in heart failure: do anthropometrics matter in clinical practice? Int J Cardiol 2008;127:331–336.\nMyers J, Prakash M, Froelicher V, et al. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med 2002;346:793–801.\nBleumink GS, Knetsch AM, Sturkenboom MC, et al. Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure. The Rotterdam Study. Eur Heart J 2004;25:1614–1619.\nReibis R, Wegscheider K, Basinkevic V, et al. Steadiness of left ventricular ejection fraction after revascularization in patients post myocardial infarction: impact on primary prevention with implantable cardioverter\u002Fdefibrillator (ICD). J Am Coll Cardiol 2007;49:16A.",{"VOID":1599},"10.1007\u002Fs00059-010-3226-5","2024-06-27T01:11:23.399+00:00","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00059-010-3226-5",[1603,1627,1642,1655,1668,1683],{"id":1604,"sortIndex":20,"researcher":19,"roles":1605,"affiliations":1606,"properties":1624,"displayName":1626,"givenName":19,"familyName":19},"3b43c88e-2e58-49f7-97a0-0df7e42a989f",[118],[1607,1615],{"id":1608,"sortIndex":20,"affiliation":1609,"properties":19},"8c596068-a3c8-4c0d-8200-c16fc5575bb5",{"id":1608,"createTime":19,"updateTime":19,"relativeEntities":1610,"slug":19,"properties":1611,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1614,"statistic":19},[],{"title":1612},{"VI":1613},"Department of Cardiology, Rehabilitation Center of Cardiovascular Disease, Klinik am See, Rüdersdorf\u002FBerlin, Germany",[],{"id":1616,"sortIndex":83,"affiliation":1617,"properties":1623},"8246b517-2f41-45b8-9b7c-772f514f2e00",{"id":1616,"createTime":19,"updateTime":19,"relativeEntities":1618,"slug":19,"properties":1619,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1622,"statistic":19},[],{"title":1620},{"VI":1621},"Kardiologische Gemeinschaftspraxis, Am Park, Sanssouci Potsdam, Potsdam, Germany",[],{},{"title":1625},{"VI":1626},"Rona K. 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struggle daily with the optimal regimen for patients with an indication for antiplatelet therapy after stenting and in patients needing oral anticoagulation treatment for atrial fibrillation (AF). This is not only difficult in patients with acute coronary syndrome (ACS) but also in the large number of patients with AF undergoing elective percutaneous coronary intervention (PCI). The challenge is to strike a balance between the increasing risk of bleeding events and ischemic or thrombotic events. Until recently, guidelines were based on expert consensus and a few small, many of them retrospective, trials. A so-called triple therapy with a vitamin K antagonist (VKA) and dual antiplatelet therapy (DAPT) with aspirin and clopidogrel was recommended for patients with AF undergoing PCI in stable coronary artery disease or for those with ACS. However, severe bleeding complications remain a major issue during triple therapy, particularly in the growing aging population. In the past year, randomized controlled trials (RCT) with direct-acting oral anticoagulants (DOACs) have modified the standard use of care, now favoring dual therapy with DOACs. This review elucidates the current influential RCTs on the new antiplatelet and anticoagulation strategies for patients with AF undergoing PCI or with ACS, and discusses whether triple therapy is still required.",{"EN":2138},"Anticoagulation strategies in patients with atrial fibrillation after PCI or with ACS",{"VOID":2140},"[\"18438544539785550232\"]",{"VOID":2142},"Schnabel RB, Yin X, Gona P et al (2015) 50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study. Lancet 386(9989):154–162. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0140-6736(14)61774-8\nSorensen NA, Shah AS, Ojeda FM et al (2016) High-sensitivity troponin and novel biomarkers for the early diagnosis of non-ST-segment elevation myocardial infarction in patients with atrial fibrillation. Eur Heart J Acute Cardiovasc Care 5(6):419–427. https:\u002F\u002Fdoi.org\u002F10.1177\u002F2048872615611108\nRubboli A, Colletta M, Valencia J et al (2009) Periprocedural management and in-hospital outcome of patients with indication for oral anticoagulation undergoing coronary artery stenting. J Interv Cardiol 22(4):390–397. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1540-8183.2009.00468.x\nSaczynski JS, McManus D, Zhou Z et al (2009) Trends in atrial fibrillation complicating acute myocardial infarction. Am J Cardiol 104(2):169–174. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.amjcard.2009.03.011\nLip GY, Windecker S, Huber K et al (2014) Management of antithrombotic therapy in atrial fibrillation patients presenting with acute coronary syndrome and\u002For undergoing percutaneous coronary or valve interventions: a joint consensus document of the European Society of Cardiology Working Group on Thrombosis, European Heart Rhythm Association (EHRA), European Association of Percutaneous Cardiovascular Interventions (EAPCI) and European Association of Acute Cardiac Care (ACCA) endorsed by the Heart Rhythm Society (HRS) and Asia-Pacific Heart Rhythm Society (APHRS). Eur Heart J 35(45):3155–3179. https:\u002F\u002Fdoi.org\u002F10.1093\u002Feurheartj\u002Fehu298\nWindecker S, Kolh P, Alfonso F et al (2014) 2014 ESC\u002FEACTS Guidelines on myocardial revascularization: the Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J 35(37):2541–2619. https:\u002F\u002Fdoi.org\u002F10.1093\u002Feurheartj\u002Fehu278\nValgimigli M, Patialiakas A, Thury A et al (2015) Zotarolimus-eluting versus bare-metal stents in uncertain drug-eluting stent candidates. J Am Coll Cardiol 65(8):805–815. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jacc.2014.11.053\nKiviniemi T, Puurunen M, Schlitt A et al (2014) Bare-metal vs. drug-eluting stents in patients with atrial fibrillation undergoing percutaneous coronary intervention. Circ J 78(11):2674–2681\nYou JJ, Singer DE, Howard PA et al (2012) Antithrombotic therapy for atrial fibrillation: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 141(2 Suppl):e531S–575S. https:\u002F\u002Fdoi.org\u002F10.1378\u002Fchest.11-2304\nKirchhof P, Benussi S, Kotecha D et al (2016) 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J 37(38):2893–2962. https:\u002F\u002Fdoi.org\u002F10.1093\u002Feurheartj\u002Fehw210\nDewilde WJ, Oirbans T, Verheugt FW et al (2013) Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial. Lancet 381(9872):1107–1115. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0140-6736(12)62177-1\nConnolly SJ, Ezekowitz MD, Yusuf S et al (2009) Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 361(12):1139–1151. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMoa0905561\nPatel MR, Mahaffey KW, Garg J et al (2011) Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 365(10):883–891. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMoa1009638\nGranger CB, Alexander JH, McMurray JJ et al (2011) Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 365(11):981–992. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMoa1107039\nGiugliano RP, Ruff CT, Braunwald E et al (2013) Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med 369(22):2093–2104. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMoa1310907\nKernan WN, Ovbiagele B, Black HR et al (2014) Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association\u002FAmerican Stroke Association. Stroke 45(7):2160–2236. https:\u002F\u002Fdoi.org\u002F10.1161\u002FSTR.0000000000000024\nMega JL, Braunwald E, Mohanavelu S et al (2009) Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, double-blind, phase II trial. Lancet 374(9683):29–38. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0140-6736(09)60738-8\nGibson CM, Mehran R, Bode C et al (2015) An open-label, randomized, controlled, multicenter study exploring two treatment strategies of rivaroxaban and a dose-adjusted oral vitamin K antagonist treatment strategy in subjects with atrial fibrillation who undergo percutaneous coronary intervention (PIONEER AF-PCI). Am Heart J 169(4):472–478\nGibson CM, Mehran R, Bode C et al (2016) Prevention of bleeding in patients with atrial fibrillation undergoing PCI. N Engl J Med 375(25):2423–2434. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMoa1611594\nCannon CP, Bhatt DL, Oldgren J et al (2017) Dual antithrombotic therapy with dabigatran after PCI in atrial fibrillation. 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