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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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SCIE","scie",[940,813],"SCIE","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=1757-4749",[943,944],"4b2c1694-c69d-4b20-b2eb-9687848dfb30","a2123f74-a835-4ccb-bfa4-b05c84c377d0",{"id":946,"indexDatabase":947,"url":952,"indexYears":953,"academicFieldIds":954,"indexDatabaseRanking":960},"2cb22a12-b865-4803-929b-6110bf9df16b",{"id":775,"createTime":28,"updateTime":28,"relativeEntities":948,"label":949,"description":950,"key":781,"publicationTags":951,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],"https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F20500195020","2009-2025",[955,956,957,958,959],"dc2675ec-5c86-4689-936e-6d41e5e50f9c","c0ced3d3-d021-4548-9037-ccfceef3c31d","d39aa686-8d5d-45f0-81c4-13c21a0f2f39","1a7c8bc3-0575-4f8d-b22c-aec346a0168a","2d28dcca-8d7f-4d85-9a3f-4ae2a5d9ded0","SCOPUS__Q2",{"impactFactor":32,"impactFactorByYear":962,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":128,"totalPublicationByYear":963,"totalCitation":32,"totalCitationByYear":964,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":965,"hindexLast5Year":32,"hindex":32},{},{"2011":40,"2013":40,"2014":40,"2016":40,"2018":40,"2019":40,"2020":40,"2021":42,"2023":123,"2024":48},{},{},{"meta":967,"data":969},{"total":968},"498",[970,1425,1666,1846,1985,2204,2454,2602,2712,2840],{"id":971,"createTime":972,"updateTime":973,"relativeEntities":974,"slug":975,"properties":976,"entityType":985,"verifyStatus":26,"verifyTime":986,"verifyNote":987,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":988,"fullTextUrl":28,"authors":989,"publicationType":1357,"publisherRelationship":1358,"citationCount":28,"citationInfo":28,"publishDate":1421,"publishYear":1422,"citationAnalyzeStatus":880,"lastCitationAnalyze":28,"indexDatabases":1423,"openAccess":28,"references":28,"isForceReanalyzing":1424},"012f5695-f285-4260-898d-300f9e4c8dc9","2024-02-02T06:44:43.118+00:00","2024-12-16T04:31:00.813+00:00",[],"Genomic-characterization-of-malonate-positive-Cronobacter-sakazakii-serotype-O-2-sequence-type-64-strains-isolated-from-clinical-food-and-environment-samples",{"abstract":977,"title":979,"references":981,"doi":983},{"EN":978},"Malonate utilization, an important differential trait, well recognized as being possessed by six of the seven Cronobacter species is thought to be largely absent in Cronobacter sakazakii (Csak). The current study provides experimental evidence that confirms the presence of a malonate utilization operon in 24 strains of sequence type (ST) 64, obtained from Europe, Middle East, China, and USA; it offers explanations regarding the genomic diversity and phylogenetic relatedness among these strains, and that of other C. sakazakii strains. In this study, the presence of a malonate utilization operon in these strains was initially identified by DNA microarray analysis (MA) out of a pool of 347 strains obtained from various surveillance studies involving clinical, spices, milk powder sources and powdered infant formula production facilities in Ireland and Germany, and dried dairy powder manufacturing facilities in the USA. All ST64 C. sakazakii strains tested could utilize malonate. Zebrafish embryo infection studies showed that C. sakazakii ST64 strains are as virulent as other Cronobacter species. Parallel whole genome sequencing (WGS) and MA showed that the strains phylogenetically grouped as a separate clade among the Csak species cluster. Additionally, these strains possessed the Csak O:2 serotype. The nine-gene, ~ 7.7 kbp malonate utilization operon was located in these strains between two conserved flanking genes, gyrB and katG. Plasmidotyping results showed that these strains possessed the virulence plasmid pESA3, but in contrast to the USA ST64 Csak strains, ST64 Csak strains isolated from sources in Europe and the Middle East, did not possess the type six secretion system effector vgrG gene. Until this investigation, the presence of malonate-positive Csak strains, which are associated with foods and clinical cases, was under appreciated. If this trait was used solely to identify Cronobacter strains, many strains would likely be misidentified. Parallel WGS and MA were useful in characterizing the total genome content of these Csak O:2, ST64, malonate-positive strains and further provides an understanding of their phylogenetic relatedness among other virulent C. sakazakii strains.",{"EN":980},"Genomic characterization of malonate positive Cronobacter sakazakii serotype O:2, sequence type 64 strains, isolated from clinical, food, and environment samples",{"VOID":982},"Yan QQ, Condell O, Power K, Butler F, Tall BD, Fanning S. Cronobacter species (formerly known as Enterobacter sakazakii) in powdered infant formula: a review of our current understanding of the biology of this bacterium. J Appl Microbiol. 2012;113:1–15. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1365-2672.2012.05281.\nTall BD, Chen Y, Yan QQ, Gopinath GR, Grim CJ, Jarvis KG, Fanning S, Lampel KA. Cronobacter: an emergent pathogen causing meningitis to neonates through their feeds. 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Cronobacter gen. nov., a new genus to accommodate the biogroups of Enterobacter sakazakii, and proposal of Cronobacter sakazakii gen. nov., comb. nov., Cronobacter malonaticus sp. nov., Cronobacter turicensis sp. nov., Cronobacter muytjensii sp. nov., Cronobacter dublinensis sp. nov., Cronobacter genomospecies 1, and of three subspecies, Cronobacter dublinensis ssp. dublinensis ssp. nov., Cronobacter dublinensis ssp. lausannensis ssp. nov. and Cronobacter dublinensis ssp. lactaridi ssp. nov. Intern J Syst Evol Microbiol. 2008;58:1442–7.\nJoseph S, Cetinkaya E, Drahovska H, Levican A, Figueras MJ, Forsythe SJ. Cronobacter condimenti sp. nov., isolated from spiced meat, and Cronobacter universalis sp. nov., a species designation for Cronobacter sp. genomospecies 1, recovered from a leg infection, water and food ingredients. Intern J Syst Evol Microbiol. 2012;62:1277–83.\nEshwar AK, Tall BD, Gangiredla J, Gopinath GR, Patel IR, Neuhauss SCF, Stephan R, Lehner A. 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Curr Clin Microbiol Rep. 2018 (In press).",{"VOID":984},"10.1186\u002Fs13099-018-0238-9","PUBLICATION","2024-12-16T04:31:00.812+00:00","Auto Verify","https:\u002F\u002Fgutpathogens.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs13099-018-0238-9",[990,1006,1019,1032,1047,1060,1073,1086,1099,1112,1125,1138,1151,1164,1177,1190,1203,1216,1229,1242,1255,1270,1283,1303,1318,1331,1344],{"id":991,"sortIndex":32,"researcher":28,"roles":992,"affiliations":994,"properties":1003,"displayName":1005,"givenName":28,"familyName":28},"449b24f2-9fc9-41fe-a301-eac9aa39c254",[993],"AUTHOR",[995],{"id":996,"sortIndex":32,"affiliation":997,"properties":28},"9be3f52d-16b3-4973-b12e-32898699b5ac",{"id":996,"createTime":28,"updateTime":28,"relativeEntities":998,"slug":28,"properties":999,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1002,"statistic":28},[],{"title":1000},{"VI":1001},"Center of Food Safety and Applied Nutrition, U. S. Food and Drug Administration, Laurel, USA",[],{"title":1004},{"VI":1005},"Gopal R. Gopinath",{"id":1007,"sortIndex":40,"researcher":28,"roles":1008,"affiliations":1009,"properties":1016,"displayName":1018,"givenName":28,"familyName":28},"6a5f91e4-434e-473e-b599-42908fe5f996",[993],[1010],{"id":996,"sortIndex":32,"affiliation":1011,"properties":28},{"id":996,"createTime":28,"updateTime":28,"relativeEntities":1012,"slug":28,"properties":1013,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1015,"statistic":28},[],{"title":1014},{"VI":1001},[],{"title":1017},{"VI":1018},"Hannah R. 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Antibiotic resistance was extremely severe in E. coli LCT-EC001, mainly due to mobile genetic elements that allowed the gain of a large quantity of resistance genes. The antibiotic resistance genes of E. coli LCT-EC001 can probably be transferred to other bacteria. To the best of our knowledge, this is the first report of a strain of E. coli which has such a large amount of antibiotic resistance genes. Apart from providing an E. coli reference genome with an extremely high multidrug-resistant background for future analyses, this work also offers a strategy for investigating the complement and characteristics of genes contributing to drug resistance at the whole-genome level.",{"EN":1435},"Genomic characterization of Escherichia coli LCT-EC001, an extremely multidrug-resistant strain with an amazing number of resistance genes",{"VOID":1437},"Ashiru-Oredope D, Hopkins S. Antimicrobial resistance: moving from professional engagement to public action. J Antimicrob Chemother. 2015;70:2927–30.\nSilva ON, de la Fuente-Núñez C, Haney EF, Fensterseifer IC, Ribeiro SM, Porto WF, et al. An anti-infective synthetic peptide with dual antimicrobial and immunomodulatory activities. Sci Rep. 2016;6:35465.\nQuainoo S, Coolen JPM, van Hijum SAFT, Huynen MA, Melchers WJG, van Schaik W, et al. Whole-genome sequencing of bacterial pathogens: the future of nosocomial outbreak analysis. Clin Microbiol Rev. 2017;30:1015–63.\nLi J, Liu F, Wang Q, Ge P, Woo PC, Yan J, et al. Genomic and transcriptomic analysis of NDM-1 Klebsiella pneumoniae in spaceflight reveal mechanisms underlying environmental adaptability. Sci Rep. 2014;4:6216.\nCasaril AE, de Oliveira LP, Alonso DP, de Oliveira EF, Gomes Barrios SP, de Oliveira Moura Infran J, et al. Standardization of DNA extraction from sand flies: application to genotyping by next generation sequencing. Exp Parasitol. 2017;177:66–72. https:\u002F\u002Fgithub.com\u002Flh3\u002Freadfq.\nLi H. Fast multi-line fasta\u002Fq reader in several programming languages. 2013. https:\u002F\u002Fgithub.com\u002Flh3\u002Freadfq.\nLi R, Zhu H, Ruan J, Qian W, Fang X, Shi Z, et al. De novo assembly of human genomes with massively parallel short read sequencing. Genome Res. 2010;20(2):265–72.\nLiu T, Zhu L, Zhang Z, Jiang L, Huang H. Draft genome sequence of Bacillus sp. (2017) M13, a multidrug-resistant subclass B1 blaNDM-producing, spore-forming bacterium isolated from China. J Glob Antimicrob Resist. 2018;14:152–3.\nBesemer J, Lomsadze A, Borodovsky M. GeneMarkS: a self-training method for prediction of gene starts in microbial genomes. Implications for finding sequence motifs in regulatory regions. Nucleic Acids Res. 2001;29(12):2607–18.\nRost B. Twilight zone of protein sequence alignments. Protein Eng. 1999;12(2):85–94.\nKanehisa M, Goto S, Hattori M, Aoki-Kinoshita KF, Itoh M, Kawashima S, et al. From genomics to chemical genomics: new developments in KEGG. Nucleic Acids Res. 2006;34(Database issue):D354–7.\nTatusov RL, Fedorova ND, Jackson JD, Jacobs AR, Kiryutin B, Koonin EV, et al. The COG database: an updated version includes eukaryotes. BMC Bioinformatics. 2003;4:41.\nAshburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 2000;25(1):25–9.\nLowe TM, Eddy SR. tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. Nucleic Acids Res. 1997;25(5):955–64.\nLagesen K, Hallin P, Rødland EA, Staerfeldt HH, Rognes T, Ussery DW. RNAmmer: consistent and rapid annotation of ribosomal RNA genes. Nucleic Acids Res. 2007;35(9):3100–8.\nGardner PP, Daub J, Tate JG, Nawrocki EP, Kolbe DL, Lindgreen S, et al. Rfam: updates to the RNA families database. Nucleic Acids Res. 2009;37(Database issue):D136–40.\nKrzywinski M, Schein J, Birol I, Connors J, Gascoyne R, Horsman D, et al. Circos: an information aesthetic for comparative genomics. Genome Res. 2009;19:1639–45.\nSaha S, Bridges S, Magbanua ZV, Peterson DG. Empirical comparison of ab initio repeat finding programs. Nucleic Acids Res. 2008;36(7):2284–94.\nBenson G. Tandem repeats finder: a program to analyze DNA sequences. Nucleic Acids Res. 1999;27(2):573.\nZhou Y, Liang Y, Lynch KH, Dennis JJ, Wishart DS. PHAST: a fast phage search tool. Nucleic Acids Res. 2011;39(Web Server issue):W347–52.\nBertelli C, Brinkman FSL. Improved genomic island predictions with IslandPath-DIMOB. Bioinformatics. 2018;34(13):2161–7.\nQin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464:59–65.\nPennington THE. coli O157 outbreaks in the United Kingdom: past, present, and future. Infect Drug Resist. 2014;7:211–22.\nRohde H, Qin J, Cui Y, Li D, Loman NJ, Hentschke M, et al. Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4. N Engl J Med. 2011;365:718–24.\nHawkey PM, Jones AM. The changing epidemiology of resistance. J Antimicrob Chemother. 2009;64(Suppl 1):i3–10.\nGaldadas I, Lovera S, Pérez-Hernández G, Barnes MD, Healy J, Afsharikho H, et al. Defining the architecture of KPC-2 Carbapenemase: identifying allosteric networks to fight antibiotics resistance. Sci Rep. 2018;8:12916.\nTacconelli E, Sifakis F, Harbarth S, Schrijver R, van Mourik M, Voss A, et al. Surveillance for control of antimicrobial resistance. Lancet Infect Dis. 2017. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS1473-3099(17)30485-1.\nMasud MR, Afroz H, Fakruddin M. Prevalence of extended-spectrum β-lactamase positive bacteria in radiologically positive urinary tract infection. Springerplus. 2014;3:216.\nZhong LL, Phan HTT, Shen C, Doris-Vihta K, Sheppard AE, Huang X, et al. High rates of human fecal carriage of mcr-1-positive multi-drug resistant Enterobacteriaceae isolates emerge in China in association with successful plasmid families. Clin Infect Dis. 2018;66:676–85.\nSubedi D, Vijay AK, Willcox M. Overview of mechanisms of antibiotic resistance in Pseudomonas aeruginosa: an ocular perspective. Clin Exp Optom. 2018;101:162–71.\nMartínez JL, Baquero F. Emergence and spread of antibiotic resistance: setting a parameter space. Ups J Med Sci. 2014;119:68–77.\nCarattoli A. Plasmids and the spread of resistance. Int J Med Microbiol. 2013;303:298–304.\nCorreia S, Poeta P, Hébraud M, Capelo JL, Igrejas G. Mechanisms of quinolone action and resistance: where do we stand? J Med Microbiol. 2017;66:551–9.\nChallacombe JF, Pillai S, Kuske CR. Shared features of cryptic plasmids from environmental and pathogenic Francisella species. PLoS ONE. 2017;12:e0183554.\nSchmitz-Esser S, Penz T, Spang A, Horn M. A bacterial genome in transition–an exceptional enrichment of IS elements but lack of evidence for recent transposition in the symbiont Amoebophilus asiaticus. BMC Evol Biol. 2011;11:270.\nBennett PM. Plasmid encoded antibiotic resistance: acquisition and transfer of antibiotic resistance genes in bacteria. Br J Pharmacol. 2008;153(Suppl 1):S347–57.\nFigueiredo S, Poirel L, Papa A, Koulourida V, Nordmann P. Overexpression of the naturally occurring blaOXA-51 gene in Acinetobacter baumannii mediated by novel insertion sequence ISAba9. Antimicrob Agents Chemother. 2009;53:4045–7.\nChen DQ, Jiang YT, Feng DH, Wen SX, Su DH, Yang L. Integron mediated bacterial resistance and virulence on clinical pathogens. Microb Pathog. 2018;114:453–7.\nRangasamy K, Athiappan M, Devarajan N, Samykannu G, Parray JA, Aruljothi KN, et al. Pesticide degrading natural multidrug resistance bacterial flora. Microb Pathog. 2017;114:304–10.\nLu B, Leong HW. Computational methods for predicting genomic islands in microbial genomes. Comput Struct Biotechnol J. 2016;14:200–6.",{"VOID":1439},"10.1186\u002Fs13099-019-0298-5","https:\u002F\u002Fgutpathogens.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs13099-019-0298-5",[1442,1459,1474,1489,1504,1519,1534,1549,1564,1579],{"id":1443,"sortIndex":32,"researcher":28,"roles":1444,"affiliations":1445,"properties":1456,"displayName":1458,"givenName":28,"familyName":28},"26677619-e176-4361-8cb7-89757f3dfc6e",[993],[1446],{"id":1447,"sortIndex":32,"affiliation":1448,"properties":1454},"bd561bf5-7947-4b58-9735-720159257eeb",{"id":1447,"createTime":28,"updateTime":28,"relativeEntities":1449,"slug":28,"properties":1450,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1453,"statistic":28},[],{"title":1451},{"VI":1452},"Respiratory Diseases Department, The Second Medical Center of PLA General Hospital, Beijing, China",[],{"title":1455},{"VI":1452},{"title":1457},{"VI":1458},"Yi 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Liu",{"id":1580,"sortIndex":32,"researcher":28,"roles":1581,"affiliations":1582,"properties":1597,"displayName":1599,"givenName":28,"familyName":28},"6b2b495a-32ec-4445-94ae-dd6cccceb512",[993],[1583,1589],{"id":1447,"sortIndex":32,"affiliation":1584,"properties":28},{"id":1447,"createTime":28,"updateTime":28,"relativeEntities":1585,"slug":28,"properties":1586,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1588,"statistic":28},[],{"title":1587},{"VI":1452},[],{"id":1590,"sortIndex":32,"affiliation":1591,"properties":28},"ba2737be-8fe5-4ac5-b6e8-5553f3526caf",{"id":1590,"createTime":28,"updateTime":28,"relativeEntities":1592,"slug":28,"properties":1593,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1596,"statistic":28},[],{"title":1594},{"VI":1595},"Hyperbaric Oxygen Department, The First Medical Center of PLA General Hospital, Beijing, China",[],{"title":1598},{"VI":1599},"Xuelin Zhang",{"url":1440,"publisher":1601,"properties":1658},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1602,"slug":872,"properties":1603,"entityType":25,"verifyStatus":880,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1606,"manageAffiliations":1627,"indexDatabases":1638,"url":28,"thumbnailPath":28,"statistic":1653,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1604,"title":1605},{"VOID":875},{"EN":877},[1607,1611,1615,1619,1623],{"id":883,"createTime":28,"updateTime":28,"relativeEntities":1608,"label":1609,"description":1610,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":886},{},{"id":889,"createTime":28,"updateTime":28,"relativeEntities":1612,"label":1613,"description":1614,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":892},{},{"id":895,"createTime":28,"updateTime":28,"relativeEntities":1616,"label":1617,"description":1618,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":898},{},{"id":901,"createTime":28,"updateTime":28,"relativeEntities":1620,"label":1621,"description":1622,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":904},{},{"id":907,"createTime":28,"updateTime":28,"relativeEntities":1624,"label":1625,"description":1626,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":910},{},[1628,1633],{"id":914,"createTime":28,"updateTime":28,"relativeEntities":1629,"slug":28,"properties":1630,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1632,"statistic":28},[],{"title":1631},{"EN":918},[],{"id":921,"createTime":28,"updateTime":28,"relativeEntities":1634,"slug":28,"properties":1635,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1637,"statistic":28},[],{"title":1636},{"EN":925},[],[1639,1646],{"id":929,"indexDatabase":1640,"url":941,"indexYears":28,"academicFieldIds":1645,"indexDatabaseRanking":28},{"id":931,"createTime":28,"updateTime":28,"relativeEntities":1641,"label":1642,"description":1643,"key":938,"publicationTags":1644,"standard":28},[],{"EN":934,"VI":934},{"EN":936,"VI":937},[940,813],[943,944],{"id":946,"indexDatabase":1647,"url":952,"indexYears":953,"academicFieldIds":1652,"indexDatabaseRanking":960},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":1648,"label":1649,"description":1650,"key":781,"publicationTags":1651,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[955,956,957,958,959],{"impactFactor":32,"impactFactorByYear":1654,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":128,"totalPublicationByYear":1655,"totalCitation":32,"totalCitationByYear":1656,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":1657,"hindexLast5Year":32,"hindex":32},{},{"2011":40,"2013":40,"2014":40,"2016":40,"2018":40,"2019":40,"2020":40,"2021":42,"2023":123,"2024":48},{},{},{"pages":1659,"volume":1661},{"VOID":1660},"1-8",{"VOID":1662},"11","2019-05-21",2019,[960,940],{"id":1667,"createTime":1668,"updateTime":1669,"relativeEntities":1670,"slug":1671,"properties":1672,"entityType":985,"verifyStatus":26,"verifyTime":1669,"verifyNote":987,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1681,"fullTextUrl":28,"authors":1682,"publicationType":1357,"publisherRelationship":1780,"citationCount":28,"citationInfo":28,"publishDate":1843,"publishYear":1844,"citationAnalyzeStatus":880,"lastCitationAnalyze":28,"indexDatabases":1845,"openAccess":28,"references":28,"isForceReanalyzing":1424},"02174f54-0e52-4ce0-a3b5-e6441706b319","2024-02-09T09:43:45.256+00:00","2025-01-28T14:43:11.427+00:00",[],"Evaluation-of-the-positive-predictive-value-of-a-rapid-Immunochromatographic-test-to-detect-Campylobacter-in-stools",{"abstract":1673,"title":1675,"references":1677,"doi":1679},{"EN":1674},"The recently developed rapid immunochromatographic tests (ICT) have the potential to provide a quick and easy diagnosis of Campylobacter enteritis in comparison to culture. In a previous study we found them sensitive but lacking in specificity. The aim of the present study was to focus on the problem of specificity and determine the positive predictive value (PPV) of a positive result of the ImmunoCard Stat! Campy (Meridian Bioscience, Cincinnati, OH, USA). For this purpose, the stools positive by ICT were cultured according to 3 different protocols: Karmali agar, Preston enrichment broth subcultured on Karmali agar, and a filtration method on a blood agar without antibiotics, all incubated for 7 days at 37°C. Out of 609 stools from adults and children with community acquired enteritis, the reference methods detected 25 positive cases (4.1%) (culture: 19, specific PCR and ELISA both positive: 6) and the ICT: 31 including the 25 true positives. The PPV was 80.6%. We conclude that ICT is a good method to screen Campylobacter positive stools but because of its lack of specificity the positive stools must be tested by another method.",{"EN":1676},"Evaluation of the positive predictive value of a rapid Immunochromatographic test to detect Campylobacter in stools",{"VOID":1678},"Moore JE, Corcoran D, Dooley JS, Fanning S, Lucey B, Matsuda M, McDowell DA, Mégraud F, Millar BC, O'Mahony R, O'Riordan L, O'Rourke M, Rao JR, Rooney PJ, Sails A, Whyte P: Campylobacter. Vet Res 2005, 36: 351-82. 10.1051\u002Fvetres:2005012.\nWassenaar TM, Blaser MJ: Pathophysiology of Campylobacter jejuni infections of humans. Microbes Infect 1999, 1: 1023-33. 10.1016\u002FS1286-4579(99)80520-6.\nBessède E, Delcamp A, Sifré E, Buissonnière A, Mégraud F: New methods for detection of Campylobacters in stool samples in comparison to culture. J Clin Microbiol 2011, 49: 941-4. 10.1128\u002FJCM.01489-10.\nBessède E, Solecki O, Sifré E, Labadi L, Mégraud F: Identification of Campylobacter species and related organisms by matrix assisted laser desorption ionization-time of light (MALDI-TOF) mass spectrometry. Clin Microbiol Infect 2011, 17: 1735-9. 10.1111\u002Fj.1469-0691.2011.03468.x.\nMénard A, Dachet F, Prouzet-Mauleon V, Oleastro M, Mégraud F: Development of a real-time fluorescence resonance energy transfer PCR to identify the main pathogenic Campylobacter spp. Clin Microbiol Infect 2005, 11: 281-7. 10.1111\u002Fj.1469-0691.2005.01072.x.",{"VOID":1680},"10.1186\u002F1757-4749-4-17","https:\u002F\u002Fgutpathogens.biomedcentral.com\u002Farticles\u002F10.1186\u002F1757-4749-4-17",[1683,1707,1720,1740,1760],{"id":1684,"sortIndex":32,"researcher":28,"roles":1685,"affiliations":1686,"properties":1704,"displayName":1706,"givenName":28,"familyName":28},"cc0bf4dd-bd3c-4d3b-b144-d165034be213",[993],[1687,1695],{"id":1688,"sortIndex":32,"affiliation":1689,"properties":28},"a4c8035c-e09f-4daa-9929-60b172a508e7",{"id":1688,"createTime":28,"updateTime":28,"relativeEntities":1690,"slug":28,"properties":1691,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1694,"statistic":28},[],{"title":1692},{"VI":1693},"Université de Bordeaux, French National Reference Center for Campylobacters, Bordeaux, 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understanding of the role of the microbiota in our gut and other sites in our body is rapidly emerging and could lead to many new and innovative approaches for health care. The promise of the potential role of probiotics for the prevention and treatment of enteric and other infections as an effective solution needs to be realized. The meeting report summarizes the insights and learning from a recent symposium, \"Health Impact of Probiotics - Vision and Opportunities\" conducted in Mumbai by the Yakult India Microbiota and Probiotic Science Foundation and P.D. Hinduja National Hospital, Mumbai. The symposium reflected its objective of unraveling the potential role of probiotics for health benefits through presentations and discussions. Experts clearly highlighted the role of probiotics in improving various aspects of health and in immune modulation. The report also captures the debate and discussions on the challenges that are likely to be encountered for the use of probiotics in the country.",{"EN":1854},"Health impact of probiotics - vision and opportunities",{"VOID":1856},"Gareau MG, Sherman PM, Walker A: Probiotics and the gut microbiota in intestinal health and disease. Nat Rev Gastroenterol Hepatol. 2010, 7: 503-514. 10.1038\u002Fnrgastro.2010.117.\nMichail S, Sherman P: Nutrition and Human Health: Probiotics in Pediatric Medicine. Totawa: Humana\u002FSpringer Press, 2009.\nBlack RE, Cousens S, Johnson HL, Lawn JE, Rudan I, Bassani DG, Jha P, Campbell H, Walker CF, Cibulskis R, Eisele T, Liu L, Mathers C: Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet. 2010, 375: 1969-87. 10.1016\u002FS0140-6736(10)60549-1.\nHumphrey JH: Child undernutrition, tropical enteropathy, toilets and handwashing. Lancet. 2009, 874: 1032-35.\nSerazin AC, Shackelton LA, Wilson C, Bhan MK: Improving the performance of enteric vaccines in the developing world. Nature Immunol. 2010, 11: 769-73. 10.1038\u002Fni0910-769.\nSur D, Manna B, Niyogi SK, Ramamurthy T, Palit A, Nomoto K, Takahashi T, Shima T, Tsuji H, Kurakawa T, Takeda Y, Nair GB, Bhattacharya SK: Role of probiotic in preventing acute diarrhoea in children: a community-based, randomized, double-blind placebo-controlled field trial in an urban slum. Epidemiol Infect. 2011, 139: 919-926. 10.1017\u002FS0950268810001780.\nKubota H, Tsuji H, Matsuda K, Kurakawa T, Asahara T, Nomoto K: Detection of human intestinal catalase-negative, Gram-positive cocci by rRNA-targeted reverse transcription-PCR. Appl Environ Microbiol. 2010, 76: 5440-5451. 10.1128\u002FAEM.03132-09.\nMatsuda K, Tsuji H, Asahara T, Kado Y, Nomoto K: Sensitive quantitative detection of commensal bacteria by rRNA-targeted reverse transcription-PCR. Appl Environ Microbiol. 2007, 73: 32-39. 10.1128\u002FAEM.01224-06.\nSakaguchi S, Saito M, Tsuji H, Asahara T, Takata O, Fujimura J, Nagata S, Nomoto K, Shimizu T: Bacterial rRNA-targeted reverse transcription-PCR used to identify pathogens responsible for fever with neutropenia. J Clin Microbiol. 2010, 48: 1624-1628. 10.1128\u002FJCM.01724-09.\nBorchers AT, Selmi C, Meyers FJ, Keen CL, Gershwin ME: Probiotics and immunity. J Gastroenterol. 2009, 44 (1): 26-46. 10.1007\u002Fs00535-008-2296-0.\nShida K, Nanno M: Probiotics and immunology: separating the wheat from the chaff. Trends Immunol. 2008, 29: 565-573. 10.1016\u002Fj.it.2008.07.011.\nAso Y, Akaza H, Kotake T, Tsukamoto T, Imai K, Naito S: Preventive effect of a Lactobacillus case preparation on the recurrence of superficial bladder cancer in a double-blind trial. Eur Urol. 1995, 27: 104-109.\nIshikawa H, Akedo I, Otani T, Suzuki T, Nakamura T, Takeyama I, Ishiguro S, Miyaoka E, Sobue T, Kakizoe T: Randomized trial of dietary fiber and Lactobacillus case administration for prevention of colorectal tumors. Int J Cancer. 2005, 116: 762-767. 10.1002\u002Fijc.21115.\nMatsumoto S, Hara T, Nagaoka M, Mike A, Mitsuyama K, Sako T, Yamamoto M, Kado S, Takada T: A component of polysaccharide peptidoglycan complex on Lactobacillu induced an improvement of murine model of inflammatory bowel disease and colitis-associated cancer. Immunology. 2009, 128 (1 Suppl): e170-e180.\nChiba Y, Shida K, Nagata S, Wada M, Bian L, Wang C, Shimizu T, Yamashiro Y, Kiyoshima-Shibata J, Nanno M, Nomoto K: Well-controlled proinflammatory cytokine responses of Peyer's patch cells to probiotic Lactobacillus casei. Immunology. 2009, 130 (3): 352-62.\nSatoh Y, Shinohara K, Umezaki H, Shoji H, Satoh H, Ohtsuka Y, Shiga S, Nagata S, Shimizu T, Yamashiro Y: Bifidobacteria prevents NEC and infection in preterm infants. Inter J Probio and Prebio. 2007, 2: 149-54.\nJoint Food and Agriculture Organization\u002FWorld Health Organization: Guidelines for the evaluation of probiotics in foods. London, Ontario, Canada, 2002, 1-11.\nNg SC, Hart AL, Kamm MA, Stagg AJ, Knight SC: Mechanism of action of probiotics: recent advances. Inflamm Bowel Dis. 2009, 15: 300-310. 10.1002\u002Fibd.20602.",{"VOID":1858},"10.1186\u002F1757-4749-4-1","https:\u002F\u002Fgutpathogens.biomedcentral.com\u002Farticles\u002F10.1186\u002F1757-4749-4-1",[1861,1876,1891,1906],{"id":1862,"sortIndex":32,"researcher":28,"roles":1863,"affiliations":1864,"properties":1873,"displayName":1875,"givenName":28,"familyName":28},"56539890-92dc-45f8-8f3f-a85a16327258",[993],[1865],{"id":1866,"sortIndex":32,"affiliation":1867,"properties":28},"6603dfe1-c3cf-4d07-9ebb-9e8f06889974",{"id":1866,"createTime":28,"updateTime":28,"relativeEntities":1868,"slug":28,"properties":1869,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1872,"statistic":28},[],{"title":1870},{"VI":1871},"Yakult India Microbiota and Probiotic Science Foundation, New Delhi, India",[],{"title":1874},{"VI":1875},"Neerja Hajela",{"id":1877,"sortIndex":40,"researcher":28,"roles":1878,"affiliations":1879,"properties":1888,"displayName":1890,"givenName":28,"familyName":28},"06c68713-8bda-47eb-ab58-3a281956ae70",[993],[1880],{"id":1881,"sortIndex":32,"affiliation":1882,"properties":28},"3f56169c-7894-4751-ac98-63eabd8cee52",{"id":1881,"createTime":28,"updateTime":28,"relativeEntities":1883,"slug":28,"properties":1884,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1887,"statistic":28},[],{"title":1885},{"VI":1886},"Translational Health Science and Technology Institute, Gurgaon, India",[],{"title":1889},{"VI":1890},"G Balakrish Nair",{"id":1892,"sortIndex":123,"researcher":28,"roles":1893,"affiliations":1894,"properties":1903,"displayName":1905,"givenName":28,"familyName":28},"a81f44f1-7df7-4ebc-ba3d-b43005d72b6b",[993],[1895],{"id":1896,"sortIndex":32,"affiliation":1897,"properties":28},"14354b33-08f1-4e33-b0d0-23eb3f57b034",{"id":1896,"createTime":28,"updateTime":28,"relativeEntities":1898,"slug":28,"properties":1899,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1902,"statistic":28},[],{"title":1900},{"VI":1901},"P.D. Hinduja National Hospital, Mumbai, India",[],{"title":1904},{"VI":1905},"Philip Abraham",{"id":1907,"sortIndex":42,"researcher":28,"roles":1908,"affiliations":1909,"properties":1918,"displayName":1920,"givenName":28,"familyName":28},"b731c7e6-a0bc-4404-b52e-ee6b5894268b",[993],[1910],{"id":1911,"sortIndex":32,"affiliation":1912,"properties":28},"7edd563a-d7fa-4fe5-a0e8-15f5a2ce4627",{"id":1911,"createTime":28,"updateTime":28,"relativeEntities":1913,"slug":28,"properties":1914,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1917,"statistic":28},[],{"title":1915},{"VI":1916},"National Institute of Immunology, New Delhi India",[],{"title":1919},{"VI":1920},"Nirmal K Ganguly",{"url":1859,"publisher":1922,"properties":1979},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1923,"slug":872,"properties":1924,"entityType":25,"verifyStatus":880,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1927,"manageAffiliations":1948,"indexDatabases":1959,"url":28,"thumbnailPath":28,"statistic":1974,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1925,"title":1926},{"VOID":875},{"EN":877},[1928,1932,1936,1940,1944],{"id":883,"createTime":28,"updateTime":28,"relativeEntities":1929,"label":1930,"description":1931,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":886},{},{"id":889,"createTime":28,"updateTime":28,"relativeEntities":1933,"label":1934,"description":1935,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":892},{},{"id":895,"createTime":28,"updateTime":28,"relativeEntities":1937,"label":1938,"description":1939,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":898},{},{"id":901,"createTime":28,"updateTime":28,"relativeEntities":1941,"label":1942,"description":1943,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":904},{},{"id":907,"createTime":28,"updateTime":28,"relativeEntities":1945,"label":1946,"description":1947,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":910},{},[1949,1954],{"id":914,"createTime":28,"updateTime":28,"relativeEntities":1950,"slug":28,"properties":1951,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1953,"statistic":28},[],{"title":1952},{"EN":918},[],{"id":921,"createTime":28,"updateTime":28,"relativeEntities":1955,"slug":28,"properties":1956,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1958,"statistic":28},[],{"title":1957},{"EN":925},[],[1960,1967],{"id":929,"indexDatabase":1961,"url":941,"indexYears":28,"academicFieldIds":1966,"indexDatabaseRanking":28},{"id":931,"createTime":28,"updateTime":28,"relativeEntities":1962,"label":1963,"description":1964,"key":938,"publicationTags":1965,"standard":28},[],{"EN":934,"VI":934},{"EN":936,"VI":937},[940,813],[943,944],{"id":946,"indexDatabase":1968,"url":952,"indexYears":953,"academicFieldIds":1973,"indexDatabaseRanking":960},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":1969,"label":1970,"description":1971,"key":781,"publicationTags":1972,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[955,956,957,958,959],{"impactFactor":32,"impactFactorByYear":1975,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":128,"totalPublicationByYear":1976,"totalCitation":32,"totalCitationByYear":1977,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":1978,"hindexLast5Year":32,"hindex":32},{},{"2011":40,"2013":40,"2014":40,"2016":40,"2018":40,"2019":40,"2020":40,"2021":42,"2023":123,"2024":48},{},{},{"pages":1980,"volume":1982},{"VOID":1981},"1-6",{"VOID":1842},"2012-03-12",[960,940],{"id":1986,"createTime":1987,"updateTime":1987,"relativeEntities":1988,"slug":1989,"properties":1990,"entityType":985,"verifyStatus":880,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":2001,"fullTextUrl":28,"authors":2002,"publicationType":1357,"publisherRelationship":2143,"citationCount":28,"citationInfo":28,"publishDate":2201,"publishYear":2202,"citationAnalyzeStatus":880,"lastCitationAnalyze":28,"indexDatabases":2203,"openAccess":28,"references":28,"isForceReanalyzing":1424},"02ef8e0c-2819-40b0-badf-2cc0f8e9df5b","2024-04-05T16:20:47.274+00:00",[],"Genome-insights-of-Enterococcus-raffinosus-CX012922-isolated-from-the-feces-of-a-Crohn-s-disease-patient",{"abstract":1991,"title":1993,"keywords":1995,"references":1997,"doi":1999},{"EN":1992},"\nEnterococcus raffinosus is one of the Enterococcus species that often cause nosocomial infections. To date, only one E. raffinosus genome has been completely assembled, and the genomic features have not been characterized. Here, we report the complete genome sequence of the strain CX012922, isolated from the feces of a Crohn’s disease patient, and perform a comparative genome analysis to the relevant Enterococcus spp. strains in silico. \nDe novo assembly of the sequencing reads of the strain CX012922 generated a circular genome of 2.83 Mb and a circular megaplasmid of 0.98 Mb. Phylogenomic analysis revealed that the strain CX012922 belonged to the E. raffinosus species. By comparative genome analysis, we found that some strains previously identified as E. raffinosus or E. gilvus should be reclassified as novel species. Genome islands (GIs), virulence factors, and antibiotic genes were found in both the genome and the megaplasmid, although pathogenic genes were mainly encoded in the genome. A large proportion of the genes encoded in the megaplasmid were involved in substrate utilization, such as raffinose metabolism. Giant megaplasmids (~1 Mb) equipped with toxin-antitoxin (TA) systems generally formed symbiosis relationships with the genome of E. raffinosus strains. \nEnterococcus spp. have a higher species-level diversity than is currently appreciated. The pathogenicity of E. raffinosus is mainly determined by the genome-encoded virulence factors, while the megaplasmid broadens the gene function pool. The symbiosis between the genome and the megaplasmids endows E. raffinosus with large genomic sizes as well as versatile gene functions, especially for their colonization, adaptation, virulence, and pathogenesis in the human gut.",{"EN":1994},"Genome insights of Enterococcus raffinosus CX012922, isolated from the feces of a Crohn’s disease patient",{"EN":1996},"",{"VOID":1998},"Gilmore MS, Clewell DB, Courvalin P, Dunny GM, Murray BE, Rice LB. The enterococci: pathogenesis, molecular biology, and antibiotic resistance. Washington, DC: ASM press. 2002;10:439.\nArias CA, Murray, BE. The rise of the Enterococcus: beyond vancomycin resistance. Nat Rev Microbiol. 2012;10(4):266–278.\nCollins MD, Facklam RR, Farrow JA, Williamson R. Enterococcus raffinosus sp. nov., Enterococcus solitarius sp. nov. and Enterococcus pseudoavium sp. nov. FEMS Microbiol Lett. 1989;57(3):283–288.\nChoi HE, Lee JH, Sim YJ, Jeong HJ, Kim GC. Predictors of prolonged vancomycin-resistant enterococci colonization in acute stroke patients admitted to an intensive care unit: A retrospective cohort study. Medicine (Baltimore). 2021;100(32):e26913.\nSantimaleeworagun W, Changpradub D, Hemapanpairoa J, Thunyaharn S. Optimization of linezolid dosing regimens for treatment of vancomycin-resistant enterococci infection. Infect Chemother. 2021.\nMathur P, Hollowoa B, Lala N, Thanendrarajan S, Matin A, Kothari A, et al. Enterococcus raffinosus infection with atypical hemolytic uremic syndrome in a multiple myeloma patient after autologous stem cell transplant. Hematol Rep. 2017;9(3):7094.\nJolivet S, Fines-Guyon M, Nebbad B, Merle D, Le Pluart C, Brun-Buisson JW, et al. First nosocomial outbreak of vanA-type vancomycin-resistant Enterococcus raffinosus in France. J Hosp Infect. 2016;94(4):346–350.\nSamuel J, Coutinho H, Galloway A, Rennison ME, Kaufmann, Neil W. Glycopeptide-resistant Enterococcus raffinosus in a haematology unit: an unusual cause of a nosocomial outbreak. J Hosp Infect. 2008;70(3):294–296.\nRůžičková M., Vítězová, Kushkevych I. The characterization of Enterococcus genus: resistance mechanisms and inflammatory bowel disease. Open Med-warsaw. 2020;15(1):211–224.\nLagier JC, Dubourg G, Million M, Cadoret F, Bilen M, Fenollar F, et al. Culturing the human microbiota and culturomics. Nat Rev Microbiol. 2018;16:540–550.\nChang Y, Hou F, Pan Z, Huang ZY, Han N, Lei B, Deng HM, et al. Optimization of culturomics strategy in human fecal samples. Front Microbiol. 2019;10:2891.\nDe Coster W, D’Hert S, Schultz DT, Cruts M, Van Broeckhoven C. NanoPack: visualizing and processing long-read sequencing data. Bioinformatics. 2018;34:2666–2669.\nWick RR, Judd LM, Gorrie CL, Holt KE. Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads. PLoS Comput Biol. 2017;13:e1005595.\nParks DH, Chuvochina M, Waite DW, Rinke C, Skarshewski A, Chaumeil PA,et al. A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life. Nat Biotechnol. 2018;36(10):996–1004.\nJain C, Rodriguez-R LM, Phillippy AM, Konstantinidis KT, Aluru S. High throughput ANI analysis of 90 K prokaryotic genomes reveals clear species boundaries. Nat Commun. 2018;9(1):1–8.\nZuo G, Hao B. CVTree3 web server for whole-genome-based and alignment-free prokaryotic phylogeny and taxonomy. Genom Proteom Bioinf. 2015;13:321–331.\nCarattoli A, Zankar E, García-Fernández A, Voldby LM. Lund O, Villa L, et al. In silico detection and typing of plasmids using PlasmidFinder and plasmid multilocus sequence typing. Antimicrob Agents CH. 2014;58(7):3895–3903.\nTatiana T, Michael DC, Azat B, Vyacheslav C, Nawrocki EP, Zaslavsky L, et al. NCBI prokaryotic genome annotation pipeline. Nucleic Acids Res. 2016;44:6614–6624.\nJaime HC, Kristoffer F, Pedro CL, Damian S, Juhl JL, Von Mering C, et al. Fast genome-wide functional annotation through orthology assignment by eggNOG-Mapper. Mol Biol Evol. 2016;34:2115–2122.\nBertelli C, Laird MR, Williams KP, Simon Fraser University Research Computing Group, Lau BY, Hoad G,et al. IslandViewer 4: expanded prediction of genomic islands for larger-scale datasets. Nucleic Acids Res. 2017;45:W30-W35.\nChun J, Oren A, Ventosa A, Christensen H, Arahal DR, da Costa, MS, e al. Proposed minimal standards for the use of genome data for the taxonomy of prokaryotes. Int J Syst Evol Microbiol. 2018;68(1):461–466.\nMeinhart A, Alonso JC, Strater N, Saenger W. Crystal structure of the plasmid maintenance system epsilon\u002Fzeta: functional mechanism of toxin zeta and inactivation by epsilon 2 zeta 2 complex formation. Proc Natl Acad Sci USA. 2003;100(4):1661–6.\nSaramago M, Bárria C, Arraiano CM, Domingues S. Ribonucleases, antisense RNAs and the control of bacterial plasmids. Plasmid. 2015;78:26–36.",{"VOID":2000},"10.1186\u002Fs13099-021-00468-8","https:\u002F\u002Fgutpathogens.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs13099-021-00468-8",[2003,2018,2041,2054,2073,2092,2111,2124],{"id":2004,"sortIndex":32,"researcher":28,"roles":2005,"affiliations":2006,"properties":2015,"displayName":2017,"givenName":28,"familyName":28},"374c038d-e01e-419b-9769-b3bf3ff6bf6d",[993],[2007],{"id":2008,"sortIndex":32,"affiliation":2009,"properties":28},"62b65266-f6e7-499a-a2ff-d28aba97a715",{"id":2008,"createTime":28,"updateTime":28,"relativeEntities":2010,"slug":28,"properties":2011,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2014,"statistic":28},[],{"title":2012},{"VI":2013},"Department of Gastroenterology, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, People’s Republic of China",[],{"title":2016},{"VI":2017},"Hailan 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                          Enterococcus faecalis, generally considered as a saprophytic bowel commensal, has recently emerged as an important nosocomial pathogen causing severe urinary tract infections, surgical wound infections, bacteremia, and bacterial endocarditis. This bacterium is capable of forming biofilms on various surfaces and its high level of antibiotic resistance contributes to its pathogenicity. The aim of this study was to evaluate the effect on E. faecalis, of Substance P (SP), an antimicrobial peptide that is produced in the gut and skin. We found that SP did not have antibacterial activity against E. faecalis V583 (MIC >1000 µg\u002Fml). Conversely, SP stimulated aggregation, hydrophobicity, lactic acid and tyramine production in this bacterium. The cytotoxicity and bacterial translocation were also accelerated when E. faecalis V583 were pretreated with SP before infection of intestinal Caco-2\u002FTC7 cells. SP can modulate the physiology of E. faecalis. Extensive studies are now needed to screen within the human microbiota which bacteria are responsive to host molecules, and to identify their sensors.",{"EN":2214},"Substance P enhances lactic acid and tyramine production in Enterococcus faecalis V583 and promotes its cytotoxic effect on intestinal Caco-2\u002FTC7 cells",{"VOID":2216},"Ganz T. The role of antimicrobial peptides in innate immunity. Integr Comp Biol. 2003;243:300–4.\nBrogden KA, Ackermann M, McCray PB Jr, Tack BF. Antimicrobial peptides in animals and their role in host defences. Int J Antimicrob Agents. 2003;22:465–78.\nVizioli J, Salzet M. Antimicrobial peptides from animals: focus on invertebrates. Trends Pharmacol Sci. 2002;23:494–6.\nBrogden KA. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat Rev Microbiol. 2005;3:238–50.\nHansen CJ, Burnell KK, Brogden KA. Antimicrobial activity of Substance P and neuropeptide Y against laboratory strains of bacteria and oral microorganisms. J Neuroimmunol. 2006;177:215–8.\nKowalska K, Carr DB, Lipkowski AW. Direct antimicrobial properties of Substance P. Life Sci. 2002;71:747–50.\nShimizu M, Shigeri Y, Tatsu Y, Yoshikawa S, Yumoto N. Enhancement of antimicrobial activity of neuropeptide Y by N-terminal truncation. Antimicrob Agents Chemother. 1998;42:2745–6.\nHolzer P, Farzi A. Neuropeptides and the microbiota–gut–brain axis. Adv Exp Med Biol. 2014;817:195–219.\nMijouin L, Hillion M, Ramdani Y, Jaouen T, Duclairoir-Poc C, Follet-Gueye ML, Lati E, Yvergnaux F, Driouich A, Lefeuvre L, Farmer C, Misery L, Feuilloley MG. Effects of a skin neuropeptide (Substance p) on cutaneous microflora. PLoS ONE. 2013;8:e78773.\nMargolis KG, Gershon MD. Neuropeptides and inflammatory bowel disease. Curr Opin Gastroenterol. 2009;25:503–11.\nN’Diaye A, Mijouin L, Hillion M, Diaz S, Konto-Ghiorghi Y, Percoco G, Chevalier S, Lefeuvre L, Harmer NJ, Lesouhaitier O, Feuilloley MG. Effect of Substance P in Staphylococcus aureus and Staphylococcus epidermidis virulence: implication for skin homeostasis. Front Microbiol. 2016;7:506.\nChristoffersen TE, Jensen H, Kleiveland CR, Dørum G, Jacobsen M, Lea T. In vitro comparison of commensal, probiotic and pathogenic strains of Enterococcus faecalis. Br J Nutr. 2012;108:2043–53.\nLadero V, Fernández M, Calles-Enríquez M, Sánchez-Llana E, Cañedo E, Martín MC, Alvarez MA. Is the production of the biogenic amines tyramine and putrescine a species-level trait in enterococci? Food Microbiol. 2012;30:132–8.\nLinares DM, del Rio B, Redruello B, Ladero V, Martin MC, Fernandez M, Ruas-Madiedo P, Alvarez MA. Comparative analysis of the in vitro cytotoxicity of the dietary biogenic amines tyramine and histamine. Food Chem. 2016;197:658–63.\nFranz CM, Stiles ME, Schleifer KH, Holzapfel WH. Enterococci in foods—a conundrum for food safety. Int J Food Microbiol. 2003;88:105–22.\nOgier JC, Serror P. Safety assessment of dairy microorganisms: the Enterococcus genus. Int J Food Microbiol. 2008;126:291–301.\nMcDonald JR, Olaison L, Anderson DJ, Hoen B, Miro JM, Eykyn S, Abrutyn E, Fowler VG Jr, Habib G, Selton-Suty C, Pappas PA, Cabell CH, Corey GR, Marco F, Sexton DJ. Enterococcal endocarditis: 107 cases from the international collaboration on endocarditis merged database. Am J Med. 2005;118:759–66.\nSahm DF, Kissinger J, Gilmore MS, Murray PR, Mulder R, Solliday J, Clarke B. In vitro susceptibility studies of vancomycin-resistant Enterococcus faecalis. Antimicrob Agents Chemother. 1989;33:1588–91.\nGiridhara Upadhyaya PM, Ravikumar KL, Umapathy BL. Review of virulence factors of enterococcus: an emerging nosocomial pathogen. Indian J Med Microbiol. 2009;27:301–5.\nGuzman Prieto AM, van Schaik W, Rogers MR, Coque TM, Baquero F, Corander J, Willems RJ. Global emergence and dissemination of Enterococci as nosocomial pathogens: attack of the clones? Front Microbiol. 2016;7:788.\nGilmore MS, Rauch M, Ramsey MM, Himes PR, Varahan S, Manson JM, Lebreton F, Hancock LE. Pheromone killing of multidrug-resistant Enterococcus faecalis V583 by native commensal strains. Proc Natl Acad Sci USA. 2015;112:7273–8.\nVebø HC, Snipen L, Nes IF, Brede DA. The transcriptome of the nosocomial pathogen Enterococcus faecalis V583 reveals adaptive responses to growth in blood. PLoS ONE. 2009;4:e7660.\nRana NF, Sauvageot N, Laplace JM, Bao Y, Nes I, Rincé A, Posteraro B, Sanguinetti M, Hartke A. Redox balance via lactate dehydrogenase is important for multiple stress resistance and virulence in Enterococcus faecalis. Infect Immun. 2013;81:2662–8.\nZou J, Shankar N. The opportunistic pathogen Enterococcus faecalis resists phagosome acidification and autophagy to promote intracellular survival in macrophages. Cell Microbiol. 2016;18:831–43.\nGilmore MS, Ferretti JJ. Microbiology. The thin line between gut commensal and pathogen. Science. 2003;299:1999–2002.\nEl Karim IA, Linden GJ, Orr DF, Lundy FT. Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites. J Neuroimmunol. 2008;200:11–6.\nBiaggini K, Barbey C, Borrel V, Feuilloley M, Déchelotte P, Connil N. The pathogenic potential of Pseudomonas fluorescens MFN1032 on enterocytes can be modulated by serotonin, Substance P and epinephrine. Arch Microbiol. 2015;197:983–90.\nPulido D, Moussaoui M, Nogués MV, Torrent M, Boix E. Towards the rational design of antimicrobial proteins: single point mutations can switch on bactericidal and agglutinating activities on the RNase A superfamily lineage. FEBS J. 2013;280:5841–52.\nBabii C, Bahrin LG, Neagu AN, Gostin I, Mihasan M, Birsa LM, Stefan M. Antibacterial activity and proposed action mechanism of a new class of synthetic tricyclic flavonoids. J Appl Microbiol. 2016;120:630–7.\nDel Re B, Sgorbati B, Miglioli M, Palenzona D. Adhesion, autoaggregation and hydrophobicity of 13 strains of Bifidobacterium longum. Lett Appl Microbiol. 2000;31:438–42.\nKling DE, Cavicchio AJ, Sollinger CA, Madoff LC, Schnitzer JJ, Kinane TB. Lactic acid is a potential virulence factor for group B Streptococcus. Microb Pathog. 2009;46:43–52.\nLin J, Smith MP, Chapin KC, Baik HS, Bennett GN, Foster JW. Mechanisms of acid resistance in enterohemorrhagic Escherichia coli. Appl Environ Microbiol. 1996;62:3094–100.\nConnil N, Le Breton Y, Dousset X, Auffray Y, Rincé A, Prévost H. Identification of the Enterococcus faecalis tyrosine decarboxylase operon involved in tyramine production. Appl Environ Microbiol. 2002;68:3537–44.\nBargossi E, Tabanelli G, Montanari C, Lanciotti R, Gatto V, Gardini F, Torriani S. Tyrosine decarboxylase activity of enterococci grown in media with different nutritional potential: tyramine and 2-phenylethylamine accumulation and tyrDC gene expression. Front Microbiol. 2015;6:259.\nLinares DM, Fernández M, Martín MC, Alvarez MA. Tyramine biosynthesis in Enterococcus durans is transcriptionally regulated by the extracellular pH and tyrosine concentration. Microb Biotechnol. 2009;2:625–33.\nPerez M, Calles-Enríquez M, Nes I, Martin MC, Fernandez M, Ladero V, Alvarez MA. Tyramine biosynthesis is transcriptionally induced at low pH and improves the fitness of Enterococcus faecalis in acidic environments. Appl Microbiol Biotechnol. 2015;99:3547–58.\nde Fernández Palencia P, Fernández M, Mohedano ML, Ladero V, Quevedo C, Alvarez MA, López P. Role of tyramine synthesis by food-borne Enterococcus durans in adaptation to the gastrointestinal tract environment. Appl Environ Microbiol. 2011;77(2):699–702.\nPessione E. Lactic acid bacteria contribution to gut microbiota complexity: lights and shadows. Front Cell Infect Microbiol. 2012;2:86.\nLesouhaitier O, Veron W, Chapalain A, Madi A, Blier AS, Dagorn A, Connil N, Chevalier S, Orange N, Feuilloley M. Gram-negative bacterial sensors for eukaryotic signal molecules. Sens (Basel). 2009;9:6967–90.\nSandrini S, Aldriwesh M, Alruways M, Freestone P. Microbial endocrinology: host-bacteria communication within the gut microbiome. J Endocrinol. 2015;225:R21–34.\nKendall MM, Sperandio V. What a dinner party! Mechanisms and functions of interkingdom signaling in host–pathogen associations. MBio. 2016;7:e01748.\nHenderson B, Martin AC. Protein moonlighting: a new factor in biology and medicine. Biochem Soc Trans. 2014;42:1671–8.\nWang G, Xia Y, Cui J, Gu Z, Song Y, Chen YQ, Chen H, Zhang H, Chen W. The roles of moonlighting proteins in bacteria. Curr Issues Mol Biol. 2014;16:15–22.\nAl Atya AK, Drider-Hadiouche K, Ravallec R, Silvain A, Vachee A, Drider D. Probiotic potential of Enterococcus faecalis strains isolated from meconium. 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                       Vibrio cholerae is responsible for the cause of severe life-threatening infection known as cholera. The study aimed to analyze the genetic make-up of V. cholerae O139 isolates from India and compare its phylogeny with the global strains. The genome data revealed that all isolates were of same sequence type (ST69) which belongs to seventh pandemic clone, with same virulence gene profile and, antimicrobial resistance gene profile except for two isolates. No known CRISPR repeats were identified in any of these isolates. Three different phages were identified among the isolates. All the isolates were found to harbour int\n                        SXT and seventh pandemic-specific gene (VC2346). Results from this study enhance our understanding on the persistence of ST69 V. cholerae O139 over 20 years.",{"EN":2464},"Prevailing clone (ST69) of Vibrio cholerae O139 in India over 10 years",{"VOID":2466},"Jesudason MV, John TJ. The Vellore vibrio watch. Lancet. 1996;347:1493–4.\nMutreja A, Kim DW, Thomson NR, Connor TR, Lee JH, Kariuki S, et al. 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with the intensive development of methods of livestock breeding, breeders’ expectations are growing concerning feed additives that would guarantee such results as accelerating growth rate, protection of health from pathogenic infections and improvement of other production parameters such as: absorption of feed and quality of meat, milk, eggs. The main reason for their application would be a strive to achieve some beneficial effects comparable to those of antibiotic-based growth stimulators, banned on 01 January 2006. High hopes are being associated with the use of probiotics, prebiotics and synbiotics. Used mainly for maintenance of the equilibrium of the intestinal microbiota of livestock, they turn out to be an effective method in fight against pathogens posing a threat for both animals and consumers. This paper discusses definitions of probiotics, prebiotics and synbiotics. Criteria that have to be met by those kinds of formulas are also presented. The paper offers a list of the most commonly used probiotics and prebiotics and some examples of their combinations in synbiotic formulas used in animal feeding. Examples of available study results on the effect of probiotics, prebiotics and synbiotics on animal health are also summarised.",{"EN":2612},"The role of probiotics, prebiotics and synbiotics in animal nutrition",{"VOID":2614},"Truszczyński M, Pejsak Z. Wpływ stosowania u zwierząt antybiotyków na lekooporność bakterii chorobotwórczych dla człowieka. Med Weter. 2006;62:1339–43.\nBiernasiak J, Śliżewska K, Libudzisz Z. Negatywne skutki stosowania antybiotyków. Postęp Nauk Rol. 2010;3:105–17.\n.Miecznikow E. O Naturze Ludzkiej – Zarys Filozofii Optymistycznej (translation F. Wermiński). Wydawnictwo Biblioteka Naukowa. Warszawa; 1907.\nVergin F. Anti- und Probiotica. Hipokrates. 1954;25:116–9.\nLilly DM, Stillwell RH. Probiotics: growth promoting factors produced by microorganisms. Science. 1965;147:747–8.\nSperti GS. Probiotics. West Point (CT): AVI Publishing Co; 1971.\nParker RB. Probiotics, the other half of the antibiotic story. Anim Nutr Health. 1974;29:4–8.\nFuller R. 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J Vet Med Sci. 2007;69:205–8.",{"VOID":2616},"10.1186\u002Fs13099-018-0250-0","2025-01-11T16:44:05.624+00:00","https:\u002F\u002Fgutpathogens.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs13099-018-0250-0",[2620,2635],{"id":2621,"sortIndex":32,"researcher":28,"roles":2622,"affiliations":2623,"properties":2632,"displayName":2634,"givenName":28,"familyName":28},"c6787f9b-2bef-43cc-a7c5-4f5ff5172409",[993],[2624],{"id":2625,"sortIndex":32,"affiliation":2626,"properties":28},"a9c823ad-27fc-45a9-9512-dab32e0d16e5",{"id":2625,"createTime":28,"updateTime":28,"relativeEntities":2627,"slug":28,"properties":2628,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2631,"statistic":28},[],{"title":2629},{"VI":2630},"Department of Biotechnology and Food Sciences, Institute of Fermentation Technology and Microbiology, Lodz University of Technology, Lodz, Poland",[],{"title":2633},{"VI":2634},"Paulina Markowiak",{"id":2636,"sortIndex":40,"researcher":28,"roles":2637,"affiliations":2638,"properties":2645,"displayName":2647,"givenName":28,"familyName":28},"4c1c6bf4-b11a-4dec-9e20-f8ff4c53ce5f",[993],[2639],{"id":2625,"sortIndex":32,"affiliation":2640,"properties":28},{"id":2625,"createTime":28,"updateTime":28,"relativeEntities":2641,"slug":28,"properties":2642,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2644,"statistic":28},[],{"title":2643},{"VI":2630},[],{"title":2646},{"VI":2647},"Katarzyna Śliżewska",{"url":2618,"publisher":2649,"properties":2706},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":2650,"slug":872,"properties":2651,"entityType":25,"verifyStatus":880,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":2654,"manageAffiliations":2675,"indexDatabases":2686,"url":28,"thumbnailPath":28,"statistic":2701,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":2652,"title":2653},{"VOID":875},{"EN":877},[2655,2659,2663,2667,2671],{"id":883,"createTime":28,"updateTime":28,"relativeEntities":2656,"label":2657,"description":2658,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":886},{},{"id":889,"createTime":28,"updateTime":28,"relativeEntities":2660,"label":2661,"description":2662,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":892},{},{"id":895,"createTime":28,"updateTime":28,"relativeEntities":2664,"label":2665,"description":2666,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":898},{},{"id":901,"createTime":28,"updateTime":28,"relativeEntities":2668,"label":2669,"description":2670,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":904},{},{"id":907,"createTime":28,"updateTime":28,"relativeEntities":2672,"label":2673,"description":2674,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":910},{},[2676,2681],{"id":914,"createTime":28,"updateTime":28,"relativeEntities":2677,"slug":28,"properties":2678,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2680,"statistic":28},[],{"title":2679},{"EN":918},[],{"id":921,"createTime":28,"updateTime":28,"relativeEntities":2682,"slug":28,"properties":2683,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2685,"statistic":28},[],{"title":2684},{"EN":925},[],[2687,2694],{"id":929,"indexDatabase":2688,"url":941,"indexYears":28,"academicFieldIds":2693,"indexDatabaseRanking":28},{"id":931,"createTime":28,"updateTime":28,"relativeEntities":2689,"label":2690,"description":2691,"key":938,"publicationTags":2692,"standard":28},[],{"EN":934,"VI":934},{"EN":936,"VI":937},[940,813],[943,944],{"id":946,"indexDatabase":2695,"url":952,"indexYears":953,"academicFieldIds":2700,"indexDatabaseRanking":960},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":2696,"label":2697,"description":2698,"key":781,"publicationTags":2699,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[955,956,957,958,959],{"impactFactor":32,"impactFactorByYear":2702,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":128,"totalPublicationByYear":2703,"totalCitation":32,"totalCitationByYear":2704,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":2705,"hindexLast5Year":32,"hindex":32},{},{"2011":40,"2013":40,"2014":40,"2016":40,"2018":40,"2019":40,"2020":40,"2021":42,"2023":123,"2024":48},{},{},{"pages":2707,"volume":2709},{"VOID":2708},"1-20",{"VOID":1420},"2018-06-06",[960,940],{"id":2713,"createTime":2714,"updateTime":2715,"relativeEntities":2716,"slug":2717,"properties":2718,"entityType":985,"verifyStatus":26,"verifyTime":2715,"verifyNote":987,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":2727,"fullTextUrl":28,"authors":2728,"publicationType":1357,"publisherRelationship":2774,"citationCount":28,"citationInfo":28,"publishDate":2837,"publishYear":2838,"citationAnalyzeStatus":880,"lastCitationAnalyze":28,"indexDatabases":2839,"openAccess":28,"references":28,"isForceReanalyzing":1424},"074ab232-913b-41fb-b032-53e01cade045","2023-12-06T17:01:34.098+00:00","2025-02-18T08:01:32.086+00:00",[],"Lactobacillus-delbrueckii-ssp-bulgaricus-B-30892-can-inhibit-cytotoxic-effects-and-adhesion-of-pathogenic-Clostridium-difficile-to-Caco-2-cells",{"abstract":2719,"title":2721,"references":2723,"doi":2725},{"EN":2720},"Probiotic microorganisms are receiving increasing interest for use in the prevention, treatment, or dietary management of certain diseases, including antibiotic-associated diarrhea (AAD). Clostridium difficile is the most common cause of AAD and the resulting C. difficile – mediated infection (CDI), is potentially deadly. C. difficile associated diarrhea (CDAD) is manifested by severe inflammation and colitis, mostly due to the release of two exotoxins by C. difficile causing destruction of epithelial cells in the intestine. The aim of this study was to determine the effect of probiotic bacteria Lactobacillus delbrueckii ssp. bulgaricus B-30892 (LDB B-30892) on C. difficile-mediated cytotoxicity using Caco-2 cells as a model. Experiments were carried out to test if the cytotoxicity induced by C. difficile- conditioned-medium on Caco-2 cells can be altered by cell-free supernatant (CFS) from LDB B-30892 in different dilutions (1:2 to 1:2048). In a similar experimental setup, comparative evaluations of other probiotic strains were made by contrasting the results from these strains with the results from LDB B-30892, specifically the ability to affect C. difficile induced cytotoxicity on Caco-2 monolayers. Adhesion assays followed by quantitative analysis by Giemsa staining were conducted to test if the CFSs from LDB B-30892 and other probiotic test strains have the capability to alter the adhesion of C. difficile to the Caco-2 monolayer. Experiments were also performed to evaluate if LDB B-30892 or its released components have any bactericidal effect on C. difficile. Co-culturing of LDB B-30892 with C. difficile inhibited the C. difficile- mediated cytotoxicity on Caco-2 cells. When CFS from LDB B-30892-C. difficile co-culture was administered (up to a dilution of 1:16) on Caco-2 monolayer, there were no signs of cytotoxicity. When CFS from separately grown LDB B-30892 was mixed with the cell-free toxin preparation (CFT) of separately cultured C. difficile, the LDB B-30892 CFS was inhibitory to C. difficile CFT-mediated cytotoxicity at a ratio of 1:8 (LDB B-30892 CFS:C. difficile CFT). We failed to find any similar inhibition of C. difficile- mediated cytotoxicity when other probiotic organisms were tested in parallel to LDB B-30892. Our data of cytotoxicity experiments suggest that LDB B-30892 releases one or more bioactive component(s) into the CFS, which neutralizes the cytotoxicity induced by C. difficile, probably by inactivating its toxin(s). Our data also indicate that CFS from LDB B-30892 reduced the adhesion of C. difficile by 81%, which is significantly (P \u003C0.01) higher than all other probiotic organisms tested in this study. This study reveals the very first findings that Lactobacillus delbrueckii ssp. bulgaricus B-30892 (LDB B-30892) can eliminate C. difficile-mediated cytotoxicity, using Caco-2 cells as a model. The study also demonstrates that LDB B-30892 can reduce the colonization of C. difficile cells in colorectal cells. More study is warranted to elucidate the specific mechanism of action of such reduction of cytotoxicity and colonization.",{"EN":2722},"Lactobacillus delbrueckii ssp. bulgaricus B-30892 can inhibit cytotoxic effects and adhesion of pathogenic Clostridium difficile to Caco-2 cells",{"VOID":2724},"Marshall JC: Daily use of a Lactobacilli probiotic prevented antibiotic-associated diarrhea in hospitalized patients. ACP J Club. 2008, 149 (1): 10-\nDoron SI, Hibberd PL, Gorbach SL: Probiotics for prevention of antibiotic-associated diarrhea. 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Infect Immun. 2008, 76 (4): 1340-1348. 10.1128\u002FIAI.00778-07.",{"VOID":2726},"10.1186\u002F1757-4749-1-8","http:\u002F\u002Fgutpathogens.biomedcentral.com\u002Farticles\u002F10.1186\u002F1757-4749-1-8",[2729,2744,2759],{"id":2730,"sortIndex":32,"researcher":28,"roles":2731,"affiliations":2732,"properties":2741,"displayName":2743,"givenName":28,"familyName":28},"1b198f36-610c-49a6-8004-c86f48bd3164",[993],[2733],{"id":2734,"sortIndex":32,"affiliation":2735,"properties":28},"db72a28d-a9c8-4474-b74d-e1e11b282cf3",{"id":2734,"createTime":28,"updateTime":28,"relativeEntities":2736,"slug":28,"properties":2737,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2740,"statistic":28},[],{"title":2738},{"VI":2739},"Research and Development Division, LacPro Industries, LLC, Fort Wayne, USA",[],{"title":2742},{"VI":2743},"Pratik Banerjee",{"id":2745,"sortIndex":40,"researcher":28,"roles":2746,"affiliations":2747,"properties":2756,"displayName":2758,"givenName":28,"familyName":28},"7741310c-ce03-4821-b6be-bdf75fd150b8",[993],[2748],{"id":2749,"sortIndex":32,"affiliation":2750,"properties":28},"5a9e55d8-a9cc-45fa-b55a-9155233d4858",{"id":2749,"createTime":28,"updateTime":28,"relativeEntities":2751,"slug":28,"properties":2752,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2755,"statistic":28},[],{"title":2753},{"VI":2754},"Department of Microbiology and Immunology, Indiana University School of Medicine, Fort Wayne, USA",[],{"title":2757},{"VI":2758},"Glenn J Merkel",{"id":2760,"sortIndex":123,"researcher":28,"roles":2761,"affiliations":2762,"properties":2771,"displayName":2773,"givenName":28,"familyName":28},"565f5b52-b13f-4c91-909e-8b359541de7c",[993],[2763],{"id":2764,"sortIndex":32,"affiliation":2765,"properties":28},"355f8b9a-2bc3-4646-ab01-0d393bc8f07d",{"id":2764,"createTime":28,"updateTime":28,"relativeEntities":2766,"slug":28,"properties":2767,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2770,"statistic":28},[],{"title":2768},{"VI":2769},"Molecular Food Microbiology Laboratory, Department of Food Science, Purdue University, West Lafayette, USA",[],{"title":2772},{"VI":2773},"Arun K Bhunia",{"url":2727,"publisher":2775,"properties":2832},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":2776,"slug":872,"properties":2777,"entityType":25,"verifyStatus":880,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":2780,"manageAffiliations":2801,"indexDatabases":2812,"url":28,"thumbnailPath":28,"statistic":2827,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":2778,"title":2779},{"VOID":875},{"EN":877},[2781,2785,2789,2793,2797],{"id":883,"createTime":28,"updateTime":28,"relativeEntities":2782,"label":2783,"description":2784,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":886},{},{"id":889,"createTime":28,"updateTime":28,"relativeEntities":2786,"label":2787,"description":2788,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":892},{},{"id":895,"createTime":28,"updateTime":28,"relativeEntities":2790,"label":2791,"description":2792,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":898},{},{"id":901,"createTime":28,"updateTime":28,"relativeEntities":2794,"label":2795,"description":2796,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":904},{},{"id":907,"createTime":28,"updateTime":28,"relativeEntities":2798,"label":2799,"description":2800,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":910},{},[2802,2807],{"id":914,"createTime":28,"updateTime":28,"relativeEntities":2803,"slug":28,"properties":2804,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2806,"statistic":28},[],{"title":2805},{"EN":918},[],{"id":921,"createTime":28,"updateTime":28,"relativeEntities":2808,"slug":28,"properties":2809,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2811,"statistic":28},[],{"title":2810},{"EN":925},[],[2813,2820],{"id":929,"indexDatabase":2814,"url":941,"indexYears":28,"academicFieldIds":2819,"indexDatabaseRanking":28},{"id":931,"createTime":28,"updateTime":28,"relativeEntities":2815,"label":2816,"description":2817,"key":938,"publicationTags":2818,"standard":28},[],{"EN":934,"VI":934},{"EN":936,"VI":937},[940,813],[943,944],{"id":946,"indexDatabase":2821,"url":952,"indexYears":953,"academicFieldIds":2826,"indexDatabaseRanking":960},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":2822,"label":2823,"description":2824,"key":781,"publicationTags":2825,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[955,956,957,958,959],{"impactFactor":32,"impactFactorByYear":2828,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":128,"totalPublicationByYear":2829,"totalCitation":32,"totalCitationByYear":2830,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":2831,"hindexLast5Year":32,"hindex":32},{},{"2011":40,"2013":40,"2014":40,"2016":40,"2018":40,"2019":40,"2020":40,"2021":42,"2023":123,"2024":48},{},{},{"pages":2833,"volume":2835},{"VOID":2834},"1-11",{"VOID":2836},"1","2009-04-27",2009,[960,940],{"id":2841,"createTime":2842,"updateTime":2843,"relativeEntities":2844,"slug":2845,"properties":2846,"entityType":985,"verifyStatus":26,"verifyTime":2843,"verifyNote":987,"languages":28,"translateLanguages":28,"viewCount":40,"primaryUrl":2855,"fullTextUrl":28,"authors":2856,"publicationType":1357,"publisherRelationship":2900,"citationCount":28,"citationInfo":28,"publishDate":2963,"publishYear":2964,"citationAnalyzeStatus":880,"lastCitationAnalyze":28,"indexDatabases":2965,"openAccess":28,"references":28,"isForceReanalyzing":1424},"075fabeb-4bd0-47c3-afb5-4778ba7bafef","2024-01-16T11:15:56.039+00:00","2025-02-17T15:52:40.149+00:00",[],"Production-of-highly-immunogenic-and-safe-Triton-X-100-produced-bacterial-ghost-vaccine-against-Shigella-flexneri-2b-serotype",{"abstract":2847,"title":2849,"references":2851,"doi":2853},{"EN":2848},"Bacterial ghost cells (BGCs) are cells were drained of their genetic and cytoplasmic components. This work aimed to develop vaccine candidates against the Shigella flexneri (S. flexneri) 2b serotype using the BGCs approach. For the first time, (S. flexneri) 2b serotype BGCs vaccine was prepared by incubation with Triton X-100 (TX100) for only 12 h. Its safety and immunogenicity were compared to another vaccine produced using a previously used surfactant, namely Tween 80 (TW80). Scanning electron microscopy (SEM), cellular DNA, protein contents measurements, and ghost cell re-cultivation were used to confirm the successful generation of the BGCs. Immunogenicity was assessed through mice's intraperitoneal (IP) immunization followed by infection with S. flexneri ATCC 12022. Finally, histopathological examination was carried out. Viable colony forming units (CFUs) of S. flexneri were counted from stool samples as well as homogenized colon tissues of the non-immunized challenged group. Immunized mice sera showed a significant increase in serum bactericidal activity of both preparations (TX100 = 40% and TW80 = 56%) compared to the non-immunized challenged group (positive control). The IgG levels of the bacterial ghost-vaccinated groups were four and three times greater for the TX100 and TW80 ghost vaccines, respectively, compared to that of the positive control; both bacterial ghost vaccines (BGVs) were safe and effective, according to the results of the safety check tests and histopathological analysis. When comparing the BGVs prepared using TX100 and TW80 methods, the use of TX100 as a new chemical treating agent for BGC production attained robust results in terms of shorter incubation time with the targeted cells and a strong immune response against S. flexneri 2b serotype ATCC 12022 in the IP challenge test. However, a clinical study is needed to confirm the efficacy and total safety of this novel vaccine.",{"EN":2850},"Production of highly immunogenic and safe Triton X-100 produced bacterial ghost vaccine against Shigella flexneri 2b serotype",{"VOID":2852},"Nisa I, Haroon M, Qasim M, Driessen A, Nijland J, Yasin N, et al. Association of serotype with antimicrobial resistance patterns among Shigella flexneri isolates from pakistan: the importance of serotype 2b. Pediatr Infect Dis J. 2020;39(11):e352–8. https:\u002F\u002Fdoi.org\u002F10.1097\u002Finf.0000000000002791.\nWei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, et al. Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect Immun. 2003;71(5):2775–86. https:\u002F\u002Fdoi.org\u002F10.1128\u002Fiai.71.5.2775-2786.2003.\nArena ET, Campbell-Valois F-X, Tinevez J-Y, Nigro G, Sachse M, Moya-Nilges M, et al. 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