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Single locus models with an application to type 1 diabetes., Am. J. Hum. Genet., 36, 363",{},{"id":24,"text":1290,"url":24,"identifiers":1291},"10.1126\u002Fscience.273.5281.1516",{"doi":1290},{"id":24,"text":1293,"url":24,"identifiers":1294},"1997, Genetic analysis of complex diseases., Science, 275, 1329",{},{"id":24,"text":1296,"url":24,"identifiers":1297},"10.1126\u002Fscience.7777857",{"doi":1296},{"id":24,"text":1299,"url":24,"identifiers":1300},"Schaid, 1993, Genotype relative risks: Methods for design and analysis of candidate-gene association studies., Am. J. Hum. Genet., 53, 1114",{},{"id":24,"text":1302,"url":24,"identifiers":1303},"1994, Comparison of statistics for candidate gene association studies., Am. J. Hum. Genet., 55, 402",{},{"id":24,"text":1305,"url":24,"identifiers":1306},"Spielman, 1993, Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)., Am. J. Hum. 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There were no significant differences in the distribution of Y-STR haplotypes among African-American groups, whereas European-American and Hispanic groups did exhibit significant geographic heterogeneity. However, the significant heterogeneity resulted from one sample; removal of that sample in each case eliminated the significant heterogeneity. Multidimensional scaling analysis of R\u003Cjats:sub>ST\u003C\u002Fjats:sub> values indicated that African-American groups formed a distinct cluster, whereas there was some intermingling of European-American and Hispanic groups. MtDNA data exist for many of these same groups; estimates of the European-American genetic contribution to the African-American gene pool were 27.5%–33.6% for the Y-STR haplotypes and 9%–15.4% for the mtDNA types. The lack of significant geographic heterogeneity among Y-STR and mtDNA haplotypes in U.S ethnic groups means that forensic DNA databases do not need to be constructed for separate geographic regions of the U.S. Moreover, absence of significant geographic heterogeneity for these two loci means that regional variation in disease susceptibility within ethnic groups is more likely to reflect cultural\u002Fenvironmental factors, rather than any underlying genetic heterogeneity.\u003C\u002Fjats:p>",{"EN":1328},"Y Chromosome STR Haplotypes and the Genetic Structure of U.S. Populations of African, European, and Hispanic Ancestry",{"VOID":1330},"12671003",{"VOID":1332},"10.1101\u002Fgr.463003","2025-02-09T16:27:44.384+00:00",[212],"http:\u002F\u002Fgenome.cshlp.org\u002Flookup\u002Fdoi\u002F10.1101\u002Fgr.463003",[1337,1356,1371,1388,1407,1426,1445,1462],{"id":1338,"sortIndex":25,"researcher":24,"roles":1339,"affiliations":1340,"properties":1349},"a6205ebf-b238-4bc6-afc5-38ca2eebd813",[],[1341],{"id":1342,"sortIndex":25,"affiliation":1343,"properties":24},"1a77efa4-92d1-4ba6-a2a9-eb1aefeb25f1",{"id":1342,"createTime":24,"updateTime":24,"relativeEntities":1344,"slug":24,"properties":1345,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1348,"statistic":24},[],{"title":1346},{"EN":1347},"Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society",[],{"orcid":1350,"title":1352,"openalex":1354},{"VOID":1351},"https:\u002F\u002Forcid.org\u002F0000-0002-4958-847X",{"EN":1353},"Manfred Kayser",{"VOID":1355},"A5054937522",{"id":1357,"sortIndex":110,"researcher":24,"roles":1358,"affiliations":1359,"properties":1366},"f1af5b3d-c612-4798-a59c-ca8241c7f095",[],[1360],{"id":1342,"sortIndex":25,"affiliation":1361,"properties":24},{"id":1342,"createTime":24,"updateTime":24,"relativeEntities":1362,"slug":24,"properties":1363,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1365,"statistic":24},[],{"title":1364},{"EN":1347},[],{"title":1367,"openalex":1369},{"EN":1368},"Silke Brauer",{"VOID":1370},"A5028661577",{"id":1372,"sortIndex":111,"researcher":24,"roles":1373,"affiliations":1374,"properties":1383},"5e3e1abb-fc0f-4aa6-a91f-71044e0f39d4",[],[1375],{"id":1376,"sortIndex":25,"affiliation":1377,"properties":24},"0ad4d782-a3cf-4dd8-8575-bf0fe9544f0e",{"id":1376,"createTime":24,"updateTime":24,"relativeEntities":1378,"slug":24,"properties":1379,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1382,"statistic":24},[],{"title":1380},{"VI":1381},"Max Planck Institute for Evolutionary Anthropology",[],{"title":1384,"openalex":1386},{"EN":1385},"Hiltrud Schädlich",{"VOID":1387},"A5025398458",{"id":1389,"sortIndex":112,"researcher":24,"roles":1390,"affiliations":1391,"properties":1400},"206ab4e3-f7ab-433e-b146-a6746fb91e91",[],[1392],{"id":1393,"sortIndex":25,"affiliation":1394,"properties":24},"70e16f27-fb0f-4eec-a5e7-bb0c7f3b0661",{"id":1393,"createTime":24,"updateTime":24,"relativeEntities":1395,"slug":24,"properties":1396,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1399,"statistic":24},[],{"title":1397},{"EN":1398},"Department of Forensic Biology",[],{"orcid":1401,"title":1403,"openalex":1405},{"VOID":1402},"https:\u002F\u002Forcid.org\u002F0000-0002-8169-6622",{"EN":1404},"Mechthild Prinz",{"VOID":1406},"A5030906309",{"id":1408,"sortIndex":108,"researcher":24,"roles":1409,"affiliations":1410,"properties":1419},"23de2900-c79f-4ce5-9780-c125acfd259d",[],[1411],{"id":1412,"sortIndex":25,"affiliation":1413,"properties":24},"8827cf97-61c8-419f-82e3-82f6176bd2d5",{"id":1412,"createTime":24,"updateTime":24,"relativeEntities":1414,"slug":24,"properties":1415,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1418,"statistic":24},[],{"title":1416},{"VI":1417},"Louisiana State University",[],{"orcid":1420,"title":1422,"openalex":1424},{"VOID":1421},"https:\u002F\u002Forcid.org\u002F0000-0001-5699-863X",{"EN":1423},"Mark A. 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