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USA, 97, 11632, 10.1073\u002Fpnas.190309197",{"doi":779},"10.1073\u002Fpnas.190309197",{"id":21,"text":781,"url":21,"identifiers":782},"Moyano, 1998, Two bZIP proteins from Antirrhinum flowers preferentially bind a hybrid C-box\u002FG-box motif and help to define a new sub-family of bZIP transcription factors, Plant J., 13, 489, 10.1046\u002Fj.1365-313X.1998.00050.x",{"doi":783},"10.1046\u002Fj.1365-313X.1998.00050.x",{"id":21,"text":785,"url":21,"identifiers":786},"Seong, 2008, LebZIP2 induced by salt and drought stress and transient overexpression by Agrobacterium, BMB Rep., 41, 693, 10.5483\u002FBMBRep.2008.41.10.693",{"doi":787},"10.5483\u002FBMBRep.2008.41.10.693",{"id":21,"text":789,"url":21,"identifiers":790},"Strathmann, 2001, BZI-1 specifically heterodimerises with the tobacco bZIP transcription factors BZI-2, BZI-3\u002FTBZF and BZI-4, and is functionally involved in flower development, Plant J., 28, 397, 10.1046\u002Fj.1365-313X.2001.01164.x",{"doi":791},"10.1046\u002Fj.1365-313X.2001.01164.x",{"id":21,"text":793,"url":21,"identifiers":794},"Weiste, C., Pedrotti, L., Selvanayagam, J., Muralidhara, P., Fröschel, C., Novák, O., Ljung, K., Hanson, J., and Dröge-Laser, W. (2017). The Arabidopsis bZIP11 transcription factor links low-energy signalling to auxin-mediated control of primary root growth. PLoS Genet., 13.",{"doi":795},"10.1371\u002Fjournal.pgen.1006607",{"id":21,"text":797,"url":21,"identifiers":798},"Zhang, 2015, Connecting proline metabolism and signaling pathways in plant senescence, Front. Plant Sci., 6, 552, 10.3389\u002Ffpls.2015.00552",{"doi":799},"10.3389\u002Ffpls.2015.00552",{"id":21,"text":801,"url":21,"identifiers":802},"Shen, L., Li, F., Dong, W., Liu, W., Qian, Y., Yang, J., Wang, F., and Wu, Y. (2017). Nicotiana benthamiana NbbZIP28, a possible regulator of unfolded protein response, plays a negative role in viral infection. Eur. J. Plant Pathol., 1–13.",{"doi":803},"10.1007\u002Fs10658-017-1231-8",{"id":21,"text":805,"url":21,"identifiers":806},"Angelos, 2017, Maintaining the factory: The roles of the unfolded protein response in cellular homeostasis in plants, Plant J., 90, 671, 10.1111\u002Ftpj.13449",{"doi":807},"10.1111\u002Ftpj.13449",{"id":21,"text":809,"url":21,"identifiers":810},"Liu, 2007, An endoplasmic reticulum stress response in Arabidopsis is mediated by proteolytic processing and nuclear relocation of a membrane-associated transcription factor, bZIP28, Plant Cell, 19, 4111, 10.1105\u002Ftpc.106.050021",{"doi":811},"10.1105\u002Ftpc.106.050021",{"id":21,"text":813,"url":21,"identifiers":814},"Popova, 2008, Differential transcript regulation in Arabidopsis thaliana and the halotolerant Lobularia maritima indicates genes with potential function in plant salt adaptation, Gene, 423, 142, 10.1016\u002Fj.gene.2008.07.017",{"doi":815},"10.1016\u002Fj.gene.2008.07.017",{"id":21,"text":817,"url":21,"identifiers":818},"Yang, 2009, The Arabidopsis basic leucine zipper transcription factor AtbZIP24 regulates complex transcriptional networks involved in abiotic stress resistance, Gene, 436, 45, 10.1016\u002Fj.gene.2009.02.010",{"doi":819},"10.1016\u002Fj.gene.2009.02.010",{"id":21,"text":821,"url":21,"identifiers":822},"Herrero, 2010, Arabidopsis thaliana transcription factors bZIP19 and bZIP23 regulate the adaptation to zinc deficiency, Proc. 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Rep., 7, 3806, 10.1038\u002Fs41598-017-03903-6",{"doi":827},"10.1038\u002Fs41598-017-03903-6",false,{"id":830,"createTime":831,"updateTime":831,"relativeEntities":832,"slug":833,"properties":834,"entityType":126,"verifyStatus":127,"verifyTime":831,"verifyNote":129,"languages":845,"translateLanguages":21,"viewCount":22,"primaryUrl":846,"fullTextUrl":21,"authors":847,"publicationType":462,"publisherRelationship":1044,"citationCount":392,"citationInfo":1098,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":1100,"openAccess":21,"references":1101,"isForceReanalyzing":828},"b1d0ada3-6ce8-4a1f-8826-f4e01087f6f5","2025-02-08T04:37:04.247+00:00",[],"Somatic-Reversion-of-a-Novel-IL2RG-Mutation-Resulting-in-Atypical-X-Linked-Combined-Immunodeficiency",{"openalex":835,"abstract":837,"title":839,"pm":841,"doi":843},{"VOID":836},"W4200441667",{"EN":838},"\u003Cjats:p>Mutations of the IL2RG gene, which encodes for the interleukin-2 receptor common gamma chain (γC, CD132), can lead to X-linked severe combined immunodeficiency (X-SCID) associated with a T−B+NK− phenotype as a result of dysfunctional γC-JAK3-STAT5 signaling. Lately, hypomorphic mutations of the IL2RG gene have been described causing atypical SCID with a milder phenotype. Here, we report three brothers with low-normal lymphocyte counts and susceptibility to recurrent respiratory infections and cutaneous warts. The clinical presentation combined with dysgammaglobulinemia suspected an inherited immunity disorder, which has been proven by Next Generation Sequencing as a novel c.458T > C; p.Ile153Thr IL2RG missense-mutation. Subsequent functional characterization revealed impaired T-cell proliferation, low TREC levels and a skewed TCR Vβ repertoire in all three patients. Interestingly, investigation of various subpopulations showed normal expression of CD132 but with partially impaired STAT5 phosphorylation compared to healthy controls. Additionally, we performed precise genetic analysis of subpopulations revealing spontaneous somatic reversion, predominately in lymphoid derived CD3+, CD4+ and CD8+ T cells. Our data demonstrate that the atypical SCID phenotype noticed in these three brothers is due to the combination of hypomorphic IL-2RG function and somatic reversion.\u003C\u002Fjats:p>",{"EN":840},"Somatic Reversion of a Novel IL2RG Mutation Resulting in Atypical X-Linked Combined 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Genet., 2, 1099, 10.1093\u002Fhmg\u002F2.8.1099",{"doi":1105},"10.1093\u002Fhmg\u002F2.8.1099",{"id":21,"text":1107,"url":21,"identifiers":1108},"Puck, 1997, Mutation analysis of IL2RG in human X-linked severe combined immunodeficiency, Blood, 89, 1968",{},{"id":21,"text":1110,"url":21,"identifiers":1111},"Miyazaki, 1994, Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits, Science, 266, 1045, 10.1126\u002Fscience.7973659",{"doi":1112},"10.1126\u002Fscience.7973659",{"id":21,"text":1114,"url":21,"identifiers":1115},"Russell, 1994, Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: Implications for XSCID and XCID, Science, 266, 1042, 10.1126\u002Fscience.7973658",{"doi":1116},"10.1126\u002Fscience.7973658",{"id":21,"text":1118,"url":21,"identifiers":1119},"Noguchi, 1993, Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans, Cell, 73, 147, 10.1016\u002F0092-8674(93)90167-O",{"doi":1120},"10.1016\u002F0092-8674(93)90167-O",{"id":21,"text":1122,"url":21,"identifiers":1123},"Lim, 2019, hypomorphic mutation: Identification of a novel pathogenic mutation in exon 8 and a review of the literature, Allergy Asthma Clin. 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Investig., 115, 3291, 10.1172\u002FJCI25178",{"doi":1136},"10.1172\u002FJCI25178",{"id":21,"text":1138,"url":21,"identifiers":1139},"Kawai, 2012, Multiple reversions of an IL2RG mutation restore T cell function in an X-linked severe combined immunodeficiency patient, J. Clin. Immunol., 32, 690, 10.1007\u002Fs10875-012-9684-1",{"doi":1140},"10.1007\u002Fs10875-012-9684-1",{"id":21,"text":1142,"url":21,"identifiers":1143},"Pyeritz, R.E., Korf, B.R., and Grody, W.W. (2018). Emery and Rimoin’s Principles and Practice of Medical Genetics and Genomics: Foundations, Academic Press.",{},{"id":21,"text":1145,"url":21,"identifiers":1146},"Jonkman, 1997, Revertant mosaicism in epidermolysis bullosa caused by mitotic gene conversion, Cell, 88, 543, 10.1016\u002FS0092-8674(00)81894-2",{"doi":1147},"10.1016\u002FS0092-8674(00)81894-2",{"id":21,"text":1149,"url":21,"identifiers":1150},"Jonkman, 2009, Revertant mosaicism—Patchwork in the skin, N. Engl. J. Med., 360, 1680, 10.1056\u002FNEJMc0809896",{"doi":1151},"10.1056\u002FNEJMc0809896",{"id":21,"text":1153,"url":21,"identifiers":1154},"Hirschhorn, 2003, In vivo reversion to normal of inherited mutations in humans, J. Med. Genet., 40, 721, 10.1136\u002Fjmg.40.10.721",{"doi":1155},"10.1136\u002Fjmg.40.10.721",{"id":21,"text":1157,"url":21,"identifiers":1158},"Hsu, 2015, IL2RG reversion event in a common lymphoid progenitor leads to delayed diagnosis and milder phenotype, J. Clin. 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Immunol., 35, 610, 10.1007\u002Fs10875-015-0202-0",{"doi":1171},"10.1007\u002Fs10875-015-0202-0",{"id":21,"text":1173,"url":21,"identifiers":1174},"Speckmann, 2008, Clinical and immunologic consequences of a somatic reversion in a patient with X-linked severe combined immunodeficiency, Blood, 112, 4090, 10.1182\u002Fblood-2008-04-153361",{"doi":1175},"10.1182\u002Fblood-2008-04-153361",{"id":21,"text":1177,"url":21,"identifiers":1178},"Stephan, 1996, Atypical X-linked severe combined immunodeficiency due to possible spontaneous reversion of the genetic defect in T cells, N. Engl. J. 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Immunol., 40, 1001, 10.1007\u002Fs10875-020-00825-3",{"doi":1191},"10.1007\u002Fs10875-020-00825-3",{"id":21,"text":1193,"url":21,"identifiers":1194},"Hazenberg, 2001, T cell receptor excision circles as markers for recent thymic emigrants: Basic aspects, technical approach, and guidelines for interpretation, J. Mol. Med., 79, 631, 10.1007\u002Fs001090100271",{"doi":1195},"10.1007\u002Fs001090100271",{"id":21,"text":1197,"url":21,"identifiers":1198},"Profaizer, 2020, A Multiplex, Droplet Digital PCR Assay for the Detection of T-Cell Receptor Excision Circles and Kappa-Deleting Recombination Excision Circles, Clin. Chem., 66, 229, 10.1373\u002Fclinchem.2019.308171",{"doi":1199},"10.1373\u002Fclinchem.2019.308171",{"id":21,"text":1201,"url":21,"identifiers":1202},"Sonntag, 2018, Immune monitoring and TCR sequencing of CD4 T cells in a long term responsive patient with metastasized pancreatic ductal carcinoma treated with individualized, neoepitope-derived multipeptide vaccines: A case report, J. Transl. Med., 16, 23, 10.1186\u002Fs12967-018-1382-1",{"doi":1203},"10.1186\u002Fs12967-018-1382-1",{"id":21,"text":1205,"url":21,"identifiers":1206},"Wang, 2005, Structure of the Quaternary Complex of Interleukin-2 with Its alpha, beta, and gammac receptors, Science, 310, 1159, 10.1126\u002Fscience.1117893",{"doi":1207},"10.1126\u002Fscience.1117893",{"id":21,"text":1209,"url":21,"identifiers":1210},"Barnes, M.R.G.I.C. (2003). Amino acid properties and consequences of substitutions. Bioinformatics for Geneticists, Wiley.",{"doi":1211},"10.1002\u002F0470867302",{"id":21,"text":1213,"url":21,"identifiers":1214},"Opdenakker, 1993, Concepts and principles of glycobiology, FASEB J., 7, 1330, 10.1096\u002Ffasebj.7.14.8224606",{"doi":1215},"10.1096\u002Ffasebj.7.14.8224606",{"id":21,"text":1217,"url":21,"identifiers":1218},"Sam-Yellowe, T.Y. (2021). T Cell Development and T Cell Receptor Structure. Immunology: Overview and Laboratory Manual, Springer.",{"doi":1219},"10.1007\u002F978-3-030-64686-8",{"id":21,"text":1221,"url":21,"identifiers":1222},"Ku, 2000, Control of homeostasis of CD8+ memory T cells by opposing cytokines, Science, 28, 675, 10.1126\u002Fscience.288.5466.675",{"doi":1223},"10.1126\u002Fscience.288.5466.675",{"id":21,"text":1225,"url":21,"identifiers":1226},"Harville, 1997, Oligoclonal expansion of CD45RO+ T lymphocytes in Omenn syndrome, J. Clin. Immunol., 17, 322, 10.1023\u002FA:1027330800085",{"doi":1227},"10.1023\u002FA:1027330800085",{"id":21,"text":1229,"url":21,"identifiers":1230},"Lev, 2012, Selective clinical and immune response of the oligoclonal autoreactive T cells in Omenn patients after cyclosporin A treatment, Clin. Exp. Immunol., 167, 338, 10.1111\u002Fj.1365-2249.2011.04508.x",{"doi":1231},"10.1111\u002Fj.1365-2249.2011.04508.x",{"id":21,"text":1233,"url":21,"identifiers":1234},"Brooks, 1999, T-cell receptor analysis in Omenn’s syndrome: Evidence for defects in gene rearrangement and assembly, Blood, 93, 242, 10.1182\u002Fblood.V93.1.242",{"doi":1235},"10.1182\u002Fblood.V93.1.242",{"id":21,"text":1237,"url":21,"identifiers":1238},"Hulstaert, 1994, Age-related changes in human blood lymphocyte subpopulations. II. Varying kinetics of percentage and absolute count measurements, Clin. Immunol. Immunopathol., 70, 152, 10.1006\u002Fclin.1994.1023",{"doi":1239},"10.1006\u002Fclin.1994.1023",{"id":21,"text":1241,"url":21,"identifiers":1242},"Gemen, 2011, Age-matched reference values for B-lymphocyte subpopulations and CVID classifications in children, Scand. J. Immunol., 74, 502, 10.1111\u002Fj.1365-3083.2011.02609.x",{"doi":1243},"10.1111\u002Fj.1365-3083.2011.02609.x",{"id":21,"text":1245,"url":21,"identifiers":1246},"Shearer, 2003, Lymphocyte subsets in healthy children from birth through 18 years of age: The Pediatric AIDS Clinical Trials Group P1009 study, J. Allergy Clin. Immunol., 112, 973, 10.1016\u002Fj.jaci.2003.07.003",{"doi":1247},"10.1016\u002Fj.jaci.2003.07.003",{"id":21,"text":1249,"url":21,"identifiers":1250},"Sehnal, 2021, Mol* Viewer: Modern web app for 3D visualization and analysis of large biomolecular structures, Nucleic Acids Res., 49, W431, 10.1093\u002Fnar\u002Fgkab314",{"doi":1251},"10.1093\u002Fnar\u002Fgkab314",{"id":1253,"createTime":1254,"updateTime":1254,"relativeEntities":1255,"slug":1256,"properties":1257,"entityType":126,"verifyStatus":127,"verifyTime":1254,"verifyNote":129,"languages":1272,"translateLanguages":21,"viewCount":22,"primaryUrl":1273,"fullTextUrl":21,"authors":1274,"publicationType":462,"publisherRelationship":1383,"citationCount":392,"citationInfo":1436,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":1438,"openAccess":21,"references":1439,"isForceReanalyzing":828},"3e9dcc9f-c253-4de7-aa97-046514a8d7a6","2025-01-30T23:10:58.969+00:00",[],"Genetic-Background-and-Antibiotic-Resistance-Profiles-of-K-pneumoniae-NDM-1-Strains-Isolated-from-UTI-ABU-and-the-GI-Tract-from-One-Hospital-in-Poland-in-Relation-to-Strains-Nationally-and-Worldwide",{"mag":1258,"pmc":1260,"openalex":1262,"abstract":1264,"title":1266,"pm":1268,"doi":1270},{"VOID":1259},"3194069003",{"VOID":1261},"8394471",{"VOID":1263},"W3194069003",{"EN":1265},"\u003Cjats:p>In recent years, there has been an observed increase in infections caused by carbapenem-resistant Klebsiella pneumonia (Kp) strains. The aim of this study was the phenotypic and genotypic analysis of eight K. pneumoniae NDM (Kp NDM) isolates, recovered in Poland during the years 2016 and 2018 from seven patients with urinary tract infections (UTIs), asymptomatic bacteriuria (ABU), or colonization of the gut. PCR melting profile genotyping indicated a close relationship between the strains derived from 2018, which were not related to the strain isolated in 2016. WGS results were analyzed in relation to international Kp isolates. Clonal and phylogenetic analyses were performed based on multilocus sequence typing (MLST) and single nucleotide polymorphisms (SNPs) of the core genome. The metallo-β-lactamase was assigned to the NDM-1 type and the sequence was identified as ST11. Eleven antimicrobial resistance genes were detected, mostly from plasmid contigs. Unprecedented profiles of plasmid replicons were described with the IncFII\u002FpKPX-1 dominant replicon. In terms of the KL24 and O2v1 capsular antigen profiles, these isolates corresponded to Greek strains. Strains isolated from UTI, ABU, and colonization GI tract patients were not carrying environment-specific virulence genes. Based on the assessment of strain relationships at the genome level and their direction of evolution, the international character of the sublines was demonstrated, with a documented epidemic potential in Poland and Greece. In conclusion, some groups of patients, e.g., renal transplant recipients or those with complicated UTIs, who are frequently hospitalized and undergoing antibiotic therapy, should be monitored not only for the risk of UTI, but also for colonization by Kp NDM strains.\u003C\u002Fjats:p>",{"EN":1267},"Genetic Background and Antibiotic Resistance Profiles of K. pneumoniae NDM-1 Strains Isolated from UTI, ABU, and the GI Tract, from One Hospital in Poland, in Relation to Strains Nationally and Worldwide",{"VOID":1269},"34440459",{"VOID":1271},"10.3390\u002Fgenes12081285",[131],"https:\u002F\u002Fwww.mdpi.com\u002F2073-4425\u002F12\u002F8\u002F1285",[1275,1294,1313,1330,1349,1366],{"id":1276,"sortIndex":22,"researcher":21,"roles":1277,"affiliations":1278,"properties":1287,"displayName":1291,"givenName":21,"familyName":21},"59f8a735-8161-4210-816f-14742b7ec09f",[],[1279],{"id":1280,"sortIndex":22,"affiliation":1281,"properties":21},"cee2b43a-abd0-4eef-91ee-9573ecb90aab",{"id":1280,"createTime":21,"updateTime":21,"relativeEntities":1282,"slug":21,"properties":1283,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":1286,"statistic":21},[],{"title":1284},{"EN":1285},"Department of Molecular Biotechnology and Microbiology, Faculty of Chemistry, Gdańsk University of Technology, ul. 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Dębinki 7, 80-952 Gdańsk, Poland",[],{"orcid":1343,"title":1345,"openalex":1347},{"VOID":1344},"https:\u002F\u002Forcid.org\u002F0000-0001-5346-8369",{"EN":1346},"Justyna Gołębiewska",{"VOID":1348},"A5015291027",{"id":1350,"sortIndex":230,"researcher":21,"roles":1351,"affiliations":1352,"properties":1361,"displayName":1363,"givenName":21,"familyName":21},"45e9707a-31e2-4c2f-86a3-74e76d78e606",[],[1353],{"id":1354,"sortIndex":22,"affiliation":1355,"properties":21},"cc961ac2-d8db-45f5-a149-9914c417d167",{"id":1354,"createTime":21,"updateTime":21,"relativeEntities":1356,"slug":21,"properties":1357,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":1360,"statistic":21},[],{"title":1358},{"EN":1359},"Laboratory of Clinical Microbiology, University Centre for Laboratory Diagnostics, Medical University of Gdańsk Clinical Centre, ul. 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Carbapenemase-producing Enterobacteriaceae in Europe: Assessment by national experts from 38 countries, May 2015, Eurosurveillance, 20, 30062, 10.2807\u002F1560-7917.ES.2015.20.45.30062",{"doi":1451},"10.2807\u002F1560-7917.ES.2015.20.45.30062",{"id":21,"text":1453,"url":21,"identifiers":1454},"Khan, 2017, Structure, Genetics and Worldwide Spread of New Delhi Metallo-β-lactamase (NDM): A threat to public health, BMC Microbiol., 17, 1, 10.1186\u002Fs12866-017-1012-8",{"doi":1455},"10.1186\u002Fs12866-017-1012-8",{"id":21,"text":1457,"url":21,"identifiers":1458},"Yong, 2009, Characterization of a new metallo-β-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India, Antimicrob. 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Infect., 16, 1699, 10.1111\u002Fj.1469-0691.2010.03385.x",{"doi":1775},"10.1111\u002Fj.1469-0691.2010.03385.x",{"id":1777,"createTime":1778,"updateTime":1778,"relativeEntities":1779,"slug":1780,"properties":1781,"entityType":126,"verifyStatus":127,"verifyTime":1796,"verifyNote":129,"languages":1797,"translateLanguages":21,"viewCount":22,"primaryUrl":1798,"fullTextUrl":21,"authors":1799,"publicationType":462,"publisherRelationship":1868,"citationCount":91,"citationInfo":1920,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":1922,"openAccess":21,"references":1923,"isForceReanalyzing":828},"158450bc-2f09-4e5c-8b8c-7cf02ce7d801","2025-01-02T14:01:51.730+00:00",[],"Morphological-Characterization-of-Flower-Buds-Development-and-Related-Gene-Expression-Profiling-at-Bud-Break-Stage-in-Heterodichogamous-Cyclocarya-paliurus-Batal-lljinskaja",{"mag":1782,"pmc":1784,"openalex":1786,"abstract":1788,"title":1790,"pm":1792,"doi":1794},{"VOID":1783},"2981088791",{"VOID":1785},"6827045",{"VOID":1787},"W2981088791",{"EN":1789},"\u003Cjats:p>Cyclocarya paliurus (Batal.) Iljinskaja, a unique species growing in southern China, is a multi-function tree species with medicinal, healthcare, material, and ornamental values. So far, sexual reproduction is the main method for extensive cultivation of C. paliurus plantations, but this is limited by low seed plumpness resulted from the character of heterodichogamy. Phenological observations have revealed the asynchronism of flower development in this species. However, its molecular mechanism remains largely unknown. To reveal molecular mechanism of heterodichogamy in C. paliurus, transcriptome of female (F) and male (M) buds from two mating types (protandry, PA; protogyny, PG) at bud break stage were sequenced using Illumina Hiseq 4000 platform. The expression patterns of both 32 genes related to flowering and 58 differentially expressed transcription factors (DETFs) selected from 6 families were divided four groups (PG-F, PG-M, PA-F, and PA-M) into two categories: first flowers (PG-F and PA-M) and later flowers (PA-F and PG-M). The results indicated that genes related to plant hormones (IAA, ABA, and GA) synthesis and response, glucose metabolism, and transcription factors (especially in MIKC family) played significant roles in regulating asynchronism of male and female flowers in the same mating type. The expression of DETFs showed two patterns. One contained DETFs up-regulated in first flowers in comparison to later flowers, and the other was the reverse. Nine genes related to flowering were selected for qRT-PCR to confirm the accuracy of RNA-seq, and generally, the RPKM values of these genes were consistent with the result of qRT-PCR. The results of this work could improve our understanding in asynchronism of floral development within one mating type in C. paliurus at transcriptional level, as well as lay a foundation for further study in heterodichogamous plants.\u003C\u002Fjats:p>",{"EN":1791},"Morphological Characterization of Flower Buds Development and Related Gene Expression Profiling at Bud Break Stage in Heterodichogamous Cyclocarya paliurus (Batal.) 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Plant Breed, 12, 1181",{},{"id":2234,"createTime":2235,"updateTime":2235,"relativeEntities":2236,"slug":2237,"properties":2238,"entityType":126,"verifyStatus":127,"verifyTime":2235,"verifyNote":129,"languages":2253,"translateLanguages":21,"viewCount":22,"primaryUrl":2254,"fullTextUrl":21,"authors":2255,"publicationType":462,"publisherRelationship":2309,"citationCount":2362,"citationInfo":2363,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":2367,"openAccess":21,"references":2368,"isForceReanalyzing":828},"2971cd95-2759-45fd-8523-80e52e408c40","2024-12-27T18:19:08.757+00:00",[],"Understanding-the-Relevance-of-DNA-Methylation-Changes-in-Immune-Differentiation-and-Disease",{"mag":2239,"pmc":2241,"openalex":2243,"abstract":2245,"title":2247,"pm":2249,"doi":2251},{"VOID":2240},"2999674525",{"VOID":2242},"7017047",{"VOID":2244},"W2999674525",{"EN":2246},"\u003Cjats:p>Immune cells are one of the most complex and diverse systems in the human organism. 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Recent technological advances have facilitated the generation of a vast amount of genome-wide DNA methylation data, providing profound insights into the roles of DNA methylation in health and disease. 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Immunol., 13, 607, 10.1097\u002FACI.0000000000000010",{"doi":3052},"10.1097\u002FACI.0000000000000010",{"id":3054,"createTime":3055,"updateTime":3055,"relativeEntities":3056,"slug":3057,"properties":3058,"entityType":126,"verifyStatus":127,"verifyTime":3055,"verifyNote":129,"languages":3073,"translateLanguages":21,"viewCount":22,"primaryUrl":3074,"fullTextUrl":21,"authors":3075,"publicationType":462,"publisherRelationship":3129,"citationCount":3183,"citationInfo":3184,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":3190,"openAccess":21,"references":3191,"isForceReanalyzing":828},"ee47ccf7-b4fb-4c22-bacb-4e708c36f70d","2024-12-24T10:20:01.582+00:00",[],"The-Role-of-Mitogen-Activated-Protein-Kinase-Activated-Protein-Kinases-MAPKAPKs-in-Inflammation",{"mag":3059,"pmc":3061,"openalex":3063,"abstract":3065,"title":3067,"pm":3069,"doi":3071},{"VOID":3060},"2109862246",{"VOID":3062},"3899974",{"VOID":3064},"W2109862246",{"EN":3066},"\u003Cjats:p>Mitogen-activated protein kinase (MAPK) pathways are implicated in several cellular processes including proliferation, differentiation, apoptosis, cell survival, cell motility, metabolism, stress response and inflammation. MAPK pathways transmit and convert a plethora of extracellular signals by three consecutive phosphorylation events involving a MAPK kinase kinase, a MAPK kinase, and a MAPK. In turn MAPKs phosphorylate substrates, including other protein kinases referred to as MAPK-activated protein kinases (MAPKAPKs). Eleven mammalian MAPKAPKs have been identified: ribosomal-S6-kinases (RSK1-4), mitogen- and stress-activated kinases (MSK1-2), MAPK-interacting kinases (MNK1-2), MAPKAPK-2 (MK2), MAPKAPK-3 (MK3), and MAPKAPK-5 (MK5). The role of these MAPKAPKs in inflammation will be reviewed.\u003C\u002Fjats:p>",{"EN":3068},"The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation",{"VOID":3070},"24705157",{"VOID":3072},"10.3390\u002Fgenes4020101",[131],"https:\u002F\u002Fwww.mdpi.com\u002F2073-4425\u002F4\u002F2\u002F101",[3076,3095,3112],{"id":3077,"sortIndex":22,"researcher":21,"roles":3078,"affiliations":3079,"properties":3088,"displayName":3092,"givenName":21,"familyName":21},"f1dd4b5b-8702-4d81-b3cd-6c6a7dcc6252",[],[3080],{"id":3081,"sortIndex":22,"affiliation":3082,"properties":21},"917a6e46-9363-4c45-ab41-ee0035b419cf",{"id":3081,"createTime":21,"updateTime":21,"relativeEntities":3083,"slug":21,"properties":3084,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":3087,"statistic":21},[],{"title":3085},{"VI":3086},"Molecular Inflammation Research Group, Department of Medical 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Ethnopharmacol., 134, 251, 10.1016\u002Fj.jep.2010.12.003",{"doi":5227},"10.1016\u002Fj.jep.2010.12.003",{"id":21,"text":5229,"url":21,"identifiers":5230},"Anderson, M. (2015). As the Wind Blows: The Effects of Long-Term Exposure to Air Pollution on Mortality. NBEI Working Pap. Ser., 21578.",{"doi":5231},"10.3386\u002Fw21578",{"id":5233,"createTime":5234,"updateTime":5234,"relativeEntities":5235,"slug":5236,"properties":5237,"entityType":126,"verifyStatus":127,"verifyTime":5234,"verifyNote":129,"languages":5252,"translateLanguages":21,"viewCount":22,"primaryUrl":5253,"fullTextUrl":21,"authors":5254,"publicationType":462,"publisherRelationship":5344,"citationCount":90,"citationInfo":5396,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":5398,"openAccess":21,"references":5399,"isForceReanalyzing":828},"e5021cd6-5e3d-4075-a4a9-2f8586b89713","2024-11-26T16:10:53.442+00:00",[],"Annotation-of-Protein-Domains-Reveals-Remarkable-Conservation-in-the-Functional-Make-up-of-Proteomes-Across-Superkingdoms",{"mag":5238,"pmc":5240,"openalex":5242,"abstract":5244,"title":5246,"pm":5248,"doi":5250},{"VOID":5239},"2073261389",{"VOID":5241},"3927607",{"VOID":5243},"W2073261389",{"EN":5245},"\u003Cjats:p>The functional repertoire of a cell is largely embodied in its proteome, the collection of proteins encoded in the genome of an organism. The molecular functions of proteins are the direct consequence of their structure and structure can be inferred from sequence using hidden Markov models of structural recognition. Here we analyze the functional annotation of protein domain structures in almost a thousand sequenced genomes, exploring the functional and structural diversity of proteomes. We find there is a remarkable conservation in the distribution of domains with respect to the molecular functions they perform in the three superkingdoms of life. In general, most of the protein repertoire is spent in functions related to metabolic processes but there are significant differences in the usage of domains for regulatory and extra-cellular processes both within and between superkingdoms. Our results support the hypotheses that the proteomes of superkingdom Eukarya evolved via genome expansion mechanisms that were directed towards innovating new domain architectures for regulatory and extra\u002Fintracellular process functions needed for example to maintain the integrity of multicellular structure or to interact with environmental biotic and abiotic factors (e.g., cell signaling and adhesion, immune responses, and toxin production). Proteomes of microbial superkingdoms Archaea and Bacteria retained fewer numbers of domains and maintained simple and smaller protein repertoires. Viruses appear to play an important role in the evolution of superkingdoms. We finally identify few genomic outliers that deviate significantly from the conserved functional design. These include Nanoarchaeum equitans, proteobacterial symbionts of insects with extremely reduced genomes, Tenericutes and Guillardia theta. These organisms spend most of their domains on information functions, including translation and transcription, rather than on metabolism and harbor a domain repertoire characteristic of parasitic organisms. In contrast, the functional repertoire of the proteomes of the Planctomycetes-Verrucomicrobia-Chlamydiae superphylum was no different than the rest of bacteria, failing to support claims of them representing a separate superkingdom. In turn, Protista and Bacteria shared similar functional distribution patterns suggesting an ancestral evolutionary link between these groups.\u003C\u002Fjats:p>",{"EN":5247},"Annotation of Protein Domains Reveals Remarkable Conservation in the Functional Make up of Proteomes Across Superkingdoms",{"VOID":5249},"24710297",{"VOID":5251},"10.3390\u002Fgenes2040869",[131],"https:\u002F\u002Fwww.mdpi.com\u002F2073-4425\u002F2\u002F4\u002F869",[5255,5274,5293,5310,5327],{"id":5256,"sortIndex":22,"researcher":21,"roles":5257,"affiliations":5258,"properties":5267,"displayName":5271,"givenName":21,"familyName":21},"23875349-a8b1-4003-99b5-3b5fbc505883",[],[5259],{"id":5260,"sortIndex":22,"affiliation":5261,"properties":21},"addbe96d-4872-4726-8a6f-5a5191e5900e",{"id":5260,"createTime":21,"updateTime":21,"relativeEntities":5262,"slug":21,"properties":5263,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":5266,"statistic":21},[],{"title":5264},{"VI":5265},"Evolutionary Bioinformatics Laboratory, Department of Crop Sciences, University of Illinois, Urbana, IL 61801, USA",[],{"orcid":5268,"title":5270,"openalex":5272},{"VOID":5269},"https:\u002F\u002Forcid.org\u002F0000-0001-7200-0788",{"EN":5271},"Arshan Nasir",{"VOID":5273},"A5046843019",{"id":5275,"sortIndex":93,"researcher":21,"roles":5276,"affiliations":5277,"properties":5286,"displayName":5290,"givenName":21,"familyName":21},"d14c3cc9-bda3-4097-a477-6d38b254bc45",[],[5278],{"id":5279,"sortIndex":22,"affiliation":5280,"properties":21},"63b952b0-4298-417a-85a9-3b1be2c93355",{"id":5279,"createTime":21,"updateTime":21,"relativeEntities":5281,"slug":21,"properties":5282,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":5285,"statistic":21},[],{"title":5283},{"EN":5284},"Mammalian NutriPhysioGenomics Laboratory, Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA",[],{"orcid":5287,"title":5289,"openalex":5291},{"VOID":5288},"https:\u002F\u002Forcid.org\u002F0000-0002-3542-3383",{"EN":5290},"Aisha Naeem",{"VOID":5292},"A5014704995",{"id":5294,"sortIndex":184,"researcher":21,"roles":5295,"affiliations":5296,"properties":5303,"displayName":5307,"givenName":21,"familyName":21},"34167bc7-f18b-4f80-8971-325a2595b929",[],[5297],{"id":5279,"sortIndex":22,"affiliation":5298,"properties":21},{"id":5279,"createTime":21,"updateTime":21,"relativeEntities":5299,"slug":21,"properties":5300,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":5302,"statistic":21},[],{"title":5301},{"EN":5284},[],{"orcid":5304,"title":5306,"openalex":5308},{"VOID":5305},"https:\u002F\u002Forcid.org\u002F0000-0002-9570-1517",{"EN":5307},"Muhammad Jawad Khan",{"VOID":5309},"A5053577816",{"id":5311,"sortIndex":206,"researcher":21,"roles":5312,"affiliations":5313,"properties":5322,"displayName":5324,"givenName":21,"familyName":21},"97919bfb-963b-4c58-a20c-4c88ee843203",[],[5314],{"id":5315,"sortIndex":22,"affiliation":5316,"properties":21},"9842bf3f-09e9-4393-b919-c868455d206c",{"id":5315,"createTime":21,"updateTime":21,"relativeEntities":5317,"slug":21,"properties":5318,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":5321,"statistic":21},[],{"title":5319},{"EN":5320},"Plant Pathology Laboratory, Department of Crop Sciences, University of Illinois, Urbana, IL 61801, USA",[],{"title":5323,"openalex":5325},{"EN":5324},"Horacio D. Lopez Nicora",{"VOID":5326},"A5032974753",{"id":5328,"sortIndex":230,"researcher":21,"roles":5329,"affiliations":5330,"properties":5337,"displayName":5341,"givenName":21,"familyName":21},"8c4b472b-6106-4bb9-9e6b-eadbdc9c5867",[],[5331],{"id":5260,"sortIndex":22,"affiliation":5332,"properties":21},{"id":5260,"createTime":21,"updateTime":21,"relativeEntities":5333,"slug":21,"properties":5334,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":5336,"statistic":21},[],{"title":5335},{"VI":5265},[],{"orcid":5338,"title":5340,"openalex":5342},{"VOID":5339},"https:\u002F\u002Forcid.org\u002F0000-0001-5854-4121",{"EN":5341},"Gustavo Caetano‐Anollés",{"VOID":5343},"A5026404241",{"url":21,"publisher":5345,"properties":5391},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":5346,"slug":10,"properties":5347,"entityType":19,"verifyStatus":20,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":22,"subjectFields":5351,"manageAffiliations":5360,"indexDatabases":5371,"url":87,"thumbnailPath":21,"statistic":5386,"gsStatistic":21,"type":21,"analyzePriority":21},[],{"issn":5348,"title":5349,"country":5350},{"VOID":15},{"EN":10},{"VOID":13},[5352,5356],{"id":25,"createTime":21,"updateTime":21,"relativeEntities":5353,"label":5354,"description":5355,"parentId":21,"standard":21,"scholarHubFieldId":21},[],{"EN":28},{},{"id":31,"createTime":21,"updateTime":21,"relativeEntities":5357,"label":5358,"description":5359,"parentId":21,"standard":21,"scholarHubFieldId":21},[],{"EN":34},{},[5361,5366],{"id":38,"createTime":21,"updateTime":21,"relativeEntities":5362,"slug":21,"properties":5363,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":5365,"statistic":21},[],{"title":5364},{"EN":42},[],{"id":45,"createTime":21,"updateTime":21,"relativeEntities":5367,"slug":21,"properties":5368,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":5370,"statistic":21},[],{"title":5369},{"EN":49},[],[5372,5379],{"id":53,"indexDatabase":5373,"url":64,"indexYears":65,"academicFieldIds":5378,"indexDatabaseRanking":69},{"id":55,"createTime":21,"updateTime":21,"relativeEntities":5374,"label":5375,"description":5376,"key":61,"publicationTags":5377,"standard":21},[],{"EN":58,"VI":58},{"EN":58,"VI":60},[63],[67,68],{"id":71,"indexDatabase":5380,"url":84,"indexYears":21,"academicFieldIds":5385,"indexDatabaseRanking":21},{"id":73,"createTime":21,"updateTime":21,"relativeEntities":5381,"label":5382,"description":5383,"key":80,"publicationTags":5384,"standard":21},[],{"EN":76,"VI":76},{"EN":78,"VI":79},[82,83],[86],{"impactFactor":22,"impactFactorByYear":5387,"i10Index":90,"i10IndexLast5Year":22,"totalPublication":91,"totalPublicationByYear":5388,"totalCitation":94,"totalCitationByYear":5389,"totalCitationPerPublication":96,"totalCitationPerPublicationByYear":5390,"hindexLast5Year":98,"hindex":98},{},{"2016":93},{},{},{"issue":5392,"pages":5393,"volume":5395},{"VOID":3182},{"VOID":5394},"869-911",{"VOID":3178},{"total":90,"publishYear":21,"statisticByYear":5397},{"2012":252,"2013":230,"2014":206,"2015":252,"2016":93,"2017":230,"2019":93,"2020":184},[],[5400,5404,5407,5411,5414,5418,5422,5426,5430,5434,5438,5442,5446,5450,5454,5458,5462,5466,5470,5474,5478,5482,5486,5489,5493,5497,5501,5505,5509,5513,5517,5521,5525,5529,5532,5536,5540,5544,5548,5552,5555,5559,5563,5567,5571,5575,5579,5583,5587,5591,5595,5599],{"id":21,"text":5401,"url":21,"identifiers":5402},"Kim, 2011, Proteome evolution and the metabolic origins of translation and cellular life, J. 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Opin. Struct. Biol., 14, 208, 10.1016\u002Fj.sbi.2004.03.011",{"doi":5421},"10.1016\u002Fj.sbi.2004.03.011",{"id":21,"text":5423,"url":21,"identifiers":5424},"Wang, 2007, Reductive evolution of architectural repertoires in proteomes and the birth of the tripartite world, Genome Res., 17, 1572, 10.1101\u002Fgr.6454307",{"doi":5425},"10.1101\u002Fgr.6454307",{"id":21,"text":5427,"url":21,"identifiers":5428},"Gerstein, 1998, Comparing genomes in terms of protein structure: Surveys of a finite parts list, FEMS Microbiol. 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Genet., 12, 393, 10.1038\u002Fnrg2984",{"doi":5598},"10.1038\u002Fnrg2984",{"id":21,"text":5600,"url":21,"identifiers":5601},"2008, Evolution of hedgehog and hedgehog-related genes, their origin from Hog proteins in ancestral eukaryotes and discovery of a novel Hint motif, BMC Genomics, 9, 127:1",{},{"id":5603,"createTime":5604,"updateTime":5604,"relativeEntities":5605,"slug":5606,"properties":5607,"entityType":126,"verifyStatus":127,"verifyTime":5604,"verifyNote":129,"languages":5622,"translateLanguages":21,"viewCount":22,"primaryUrl":5623,"fullTextUrl":21,"authors":5624,"publicationType":462,"publisherRelationship":5809,"citationCount":5862,"citationInfo":5863,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":5865,"openAccess":21,"references":5866,"isForceReanalyzing":828},"37fd76bc-715e-41fa-a409-a3ec04c0e845","2024-10-15T09:40:50.322+00:00",[],"A-Novel-G-Protein-Coupled-Receptors-Gene-from-Upland-Cotton-Enhances-Salt-Stress-Tolerance-in-Transgenic-Arabidopsis",{"mag":5608,"pmc":5610,"openalex":5612,"abstract":5614,"title":5616,"pm":5618,"doi":5620},{"VOID":5609},"2797144664",{"VOID":5611},"5924551",{"VOID":5613},"W2797144664",{"EN":5615},"\u003Cjats:p>Plants have developed a number of survival strategies which are significant for enhancing their adaptation to various biotic and abiotic stress factors. At the transcriptome level, G-protein-coupled receptors (GPCRs) are of great significance, enabling the plants to detect a wide range of endogenous and exogenous signals which are employed by the plants in regulating various responses in development and adaptation. In this research work, we carried out genome-wide analysis of target of Myb1 (TOM1), a member of the GPCR gene family. The functional role of TOM1 in salt stress tolerance was studied using a transgenic Arabidopsis plants over-expressing the gene. By the use of the functional domain PF06454, we obtained 16 TOM genes members in Gossypium hirsutum, 9 in Gossypium arboreum, and 11 in Gossypium raimondii. The genes had varying physiochemical properties, and it is significant to note that all the grand average of hydropathy (GRAVY) values were less than one, indicating that all are hydrophobic in nature. In all the genes analysed here, both the exonic and intronic regions were found. The expression level of Gh_A07G0747 (GhTOM) was significantly high in the transgenic lines as compared to the wild type; a similar trend in expression was observed in all the salt-related genes tested in this study. The study in epidermal cells confirmed the localization of the protein coded by the gene TOM1 in the plasma membrane. Analysis of anti-oxidant enzymes showed higher concentrations of antioxidants in transgenic lines and relatively lower levels of oxidant substances such as H2O2. The low malondialdehyde (MDA) level in transgenic lines indicated that the transgenic lines had relatively low level of oxidative damage compared to the wild types. The results obtained indicate that Gh_A07G0747 (GhTOM) can be a putative target gene for enhancing salt stress tolerance in plants and could be exploited in the future for the development of salt stress-tolerant cotton cultivars.\u003C\u002Fjats:p>",{"EN":5617},"A Novel G-Protein-Coupled Receptors Gene from Upland Cotton Enhances Salt Stress Tolerance in Transgenic Arabidopsis",{"VOID":5619},"29649144",{"VOID":5621},"10.3390\u002Fgenes9040209",[131],"https:\u002F\u002Fwww.mdpi.com\u002F2073-4425\u002F9\u002F4\u002F209",[5625,5644,5669,5688,5705,5724,5741,5758,5775,5792],{"id":5626,"sortIndex":22,"researcher":21,"roles":5627,"affiliations":5628,"properties":5637,"displayName":5641,"givenName":21,"familyName":21},"91d93b84-cb2f-403b-974e-227e6ff423bd",[],[5629],{"id":5630,"sortIndex":22,"affiliation":5631,"properties":21},"0a5246ac-9d67-4c7d-b1dc-d162e6080a65",{"id":5630,"createTime":21,"updateTime":21,"relativeEntities":5632,"slug":21,"properties":5633,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":5636,"statistic":21},[],{"title":5634},{"EN":5635},"Research Base in Anyang Institute of Technology, State Key Laboratory of Cotton Biology, Institute of Cotton Research, Chinese Academy of Agricultural Science (ICR, CAAS), Anyang 455000, Henan, China",[],{"orcid":5638,"title":5640,"openalex":5642},{"VOID":5639},"https:\u002F\u002Forcid.org\u002F0000-0001-6350-8416",{"EN":5641},"Pu Lu",{"VOID":5643},"A5086848389",{"id":5645,"sortIndex":93,"researcher":21,"roles":5646,"affiliations":5647,"properties":5662,"displayName":5666,"givenName":21,"familyName":21},"8666a17b-a086-4cb9-9e2f-eafcca68e1a2",[],[5648,5656],{"id":5649,"sortIndex":22,"affiliation":5650,"properties":21},"5714b138-5d74-477e-af7e-7361f631b16b",{"id":5649,"createTime":21,"updateTime":21,"relativeEntities":5651,"slug":21,"properties":5652,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":5655,"statistic":21},[],{"title":5653},{"EN":5654},"Jaramogi Oginga Odinga University of Science and Technology, P.O. 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