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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":576,"VI":577},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":579},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[583],{"id":584,"createTime":21,"updateTime":21,"relativeEntities":585,"slug":21,"properties":586,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":596,"parentIds":597,"statistic":21},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":587,"address":590,"country":593,"abbreviation":594},{"EN":588,"VI":589},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":591,"VI":592},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":111},{"VOID":595},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":22,"impactFactorByYear":601,"i10Index":22,"i10IndexLast5Year":22,"totalPublication":603,"totalPublicationByYear":604,"totalCitation":609,"totalCitationByYear":610,"totalCitationPerPublication":199,"totalCitationPerPublicationByYear":612,"hindexLast5Year":137,"hindex":137},{"2022":602,"2023":202,"2024":197},0.01,1556,{"2020":139,"2021":605,"2022":606,"2023":607,"2024":608,"2025":213},57,306,801,358,161,{"2021":235,"2022":369,"2023":611},99,{"2021":613,"2022":407,"2023":195},0.23,{"impactFactor":21,"impactFactorByYear":21,"i10Index":214,"i10IndexLast5Year":214,"totalPublication":615,"totalPublicationByYear":616,"totalCitation":615,"totalCitationByYear":617,"totalCitationPerPublication":93,"totalCitationPerPublicationByYear":620,"hindexLast5Year":141,"hindex":141},476,{"0":294,"2019":214,"2021":228,"2022":548,"2023":540,"2024":446,"2025":141,"2026":140},{"2021":134,"2022":214,"2023":250,"2024":618,"2025":449,"2026":619},136,83,{"2021":196,"2022":602,"2023":621,"2024":218,"2025":622,"2026":623},0.62,25.43,13.83,{"id":625,"createTime":626,"updateTime":471,"relativeEntities":627,"slug":628,"properties":629,"entityType":19,"verifyStatus":121,"verifyTime":21,"verifyNote":21,"languages":641,"translateLanguages":21,"viewCount":222,"subjectFields":642,"manageAffiliations":643,"indexDatabases":644,"url":645,"thumbnailPath":646,"statistic":647,"gsStatistic":683,"type":147,"analyzePriority":21},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":630,"issn":631,"title":633,"introduce":636,"gsId":639},{"VOID":111},{"VOID":632},"25252445",{"EN":634,"VI":635},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":637,"VI":638},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. Since then, the journal has grown in quality, size and scope and now comprises a dozen of serials spanning academic research. 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Although, the main text structure may vary based on the review subtopics, the articles should be formatted according to suitable Templates as research articles.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"\\n\"}]}","{\"ops\":[{\"insert\":\"Tạp chí Khoa học Trường ĐHSP Hà Nội 2 nhằm mục đích cung cấp một nền tảng liên ngành của sự phổ biến những tiến bộ của khoa học và công nghệ. Tạp chí xuất bản các bài báo gốc có giá trị khoa học hoặc công nghệ trong tất cả các lĩnh vực khoa học tự nhiên, xã hội hoặc giáo dục.\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Chuyên san Khoa học tự nhiên và công nghệ:\"},{\"insert\":\" Là các bài báo mô tả những phát hiện có giá trị trong vật lý, toán học, hóa học, sinh học; giải quyết các vấn đề kỹ thuật hoặc công nghệ.\"},{\"attributes\":{\"list\":\"bullet\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Chuyên san Khoa học Xã hội và Nhân văn:\"},{\"insert\":\" là các bài báo xuất bản chất lượng cao trong các lĩnh vực khác nhau của khoa học xã hội và nghiên cứu phát triển con người.\"},{\"attributes\":{\"list\":\"bullet\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Chuyên san Khoa học giáo dục:\"},{\"insert\":\" là các bài báo xuất bản trong lĩnh vực khoa học giáo dục và các ứng dụng của tiến bộ vào giáo dục để cải thiện và nâng cao giáo dục khoa học ở tất cả các cấp.\"},{\"attributes\":{\"list\":\"bullet\"},\"insert\":\"\\n\"},{\"insert\":\"Tạp chí trường ĐHSP Hà Nội 2 xuất bản được phản biện kín, xét duyệt bởi ít nhất 02 chuyên gia, và được đánh giá, chọn lựa từ ban biên tập và Tổng biên tập.\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Các loại bài báo\"},{\"insert\":\":\\nBài báo nghiên cứu:\"},{\"attributes\":{\"list\":\"ordered\"},\"insert\":\"\\n\"},{\"insert\":\"Báo cáo học thuật về nghiên cứu ban đầu chưa từng được xuất bản ở bất kỳ nơi nào, hay bằng bất kỳ ngôn ngữ nào khác. Bản thảo thích hợp, nên chứa các phần sau theo thứ tự: Tiêu đề, Tác giả, Liên kết tác giả, Địa chỉ email của tác giả tương ứng, Tóm tắt, Từ khóa, Danh pháp (nếu có), Giới thiệu, Thử nghiệm, Lý thuyết, Kết quả và thảo luận, Kết luận, Xung đột quan tâm, Lời cảm ơn (nếu có), Tài liệu tham khảo, Phụ lục (nếu có). Bản xuất bản trước phải được định dạng theo Mẫu (phiên bản MS-Word).\\n2. Bài báo tổng quan:\\nNgoài các bài phê bình được mời, các bài phê bình tài liệu, bài phê bình có hệ thống và bài phê bình sẽ được chấp nhận để xem xét. Bản thảo cần được soạn thảo và sắp xếp theo trình tự yêu cầu: Tên sách, Tên tác giả, Liên kết, Địa chỉ email, Tóm tắt, Từ khóa, Nội dung chính, Kết luận, Xung đột lợi ích, Lời cảm ơn (nếu có), Tài liệu tham khảo. Mặc dù, cấu trúc văn bản chính có thể thay đổi dựa trên các chủ đề phụ của bài đánh giá, các bài báo nên được định dạng theo các Mẫu phù hợp như các bài báo nghiên cứu.\\n\"}]}",{"VOID":815},"YPoBvsIAAAAJ",[],[],[],"https:\u002F\u002Fsj.hpu2.edu.vn\u002Findex.php\u002Fjournal","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F954132b5-ca74-461c-b819-45ad6e49a404\u002F2790ef1d0a7d7a40a504c2fc1647f670.jpg",{"impactFactor":22,"impactFactorByYear":822,"i10Index":22,"i10IndexLast5Year":22,"totalPublication":418,"totalPublicationByYear":824,"totalCitation":223,"totalCitationByYear":825,"totalCitationPerPublication":613,"totalCitationPerPublicationByYear":826,"hindexLast5Year":214,"hindex":214},{"2024":823},0.17,{"2022":225,"2023":367,"2024":231},{"2022":446,"2023":217,"2024":214},{"2022":258,"2023":313,"2024":254},{"impactFactor":21,"impactFactorByYear":21,"i10Index":137,"i10IndexLast5Year":137,"totalPublication":419,"totalPublicationByYear":828,"totalCitation":243,"totalCitationByYear":829,"totalCitationPerPublication":830,"totalCitationPerPublicationByYear":831,"hindexLast5Year":138,"hindex":138},{"0":214,"2022":223,"2023":225,"2024":91,"2025":234},{"2023":138,"2024":225,"2025":290,"2026":367},1.22,{"2023":204,"2024":429,"2025":832},4.56,{"id":834,"createTime":835,"updateTime":836,"relativeEntities":837,"slug":838,"properties":839,"entityType":19,"verifyStatus":121,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":91,"subjectFields":851,"manageAffiliations":852,"indexDatabases":860,"url":900,"thumbnailPath":21,"statistic":901,"gsStatistic":933,"type":147,"analyzePriority":21},"21ccdb34-414d-420f-8a60-a592a2fa848e","2023-05-29T10:42:53.358+00:00","2026-08-27T01:57:29.560+00:00",[],"Vietnam-Journal-of-Earth-Sciences",{"country":840,"eissn":841,"issn":843,"title":845,"introduce":847,"gsId":849},{"VOID":111},{"VOID":842},"26159783",{"VOID":844},"08667187",{"EN":846},"Vietnam Journal of Earth Sciences",{"EN":848},"Science of the Earth, formerly Vietnam Journal of Earth Sciences, is a peer-reviewed journal to publish high-quality articles on the entire range of earth sciences and the environment, focused on the Asia Pacific region and their correlations and connections to the globe. The journal publishes fundamental and applied research in earth sciences and the environment, including geology, geophysics, geography, soil science, hydrology, meteorology, oceanography, petroleum, geohazards, environmental sciences, environmental engineering, sustainable development, geoinformatics, geodesy, GIS, and remote sensing.",{"VOID":850},"5htfr3YAAAAJ",[],[853],{"id":164,"createTime":21,"updateTime":21,"relativeEntities":854,"slug":21,"properties":855,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":173,"parentIds":859,"statistic":21},[],{"title":856,"country":857,"abbreviation":858},{"EN":168,"VI":169},{"VOID":111},{"VOID":172},[],[861,873,884],{"id":862,"indexDatabase":863,"url":868,"indexYears":869,"academicFieldIds":870,"indexDatabaseRanking":872},"6ace2085-a177-4a27-b309-8813b832111e",{"id":55,"createTime":21,"updateTime":21,"relativeEntities":864,"label":865,"description":866,"key":61,"publicationTags":867,"standard":21},[],{"EN":58,"VI":58},{"EN":58,"VI":60},[63],"https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F21101039869","2018-2024",[871],"1689391c-5702-4349-aaa7-d720ee4321fc","NONE",{"id":874,"indexDatabase":875,"url":880,"indexYears":881,"academicFieldIds":882,"indexDatabaseRanking":21},"dadb15a8-ee22-41c2-a287-49e969d9a998",{"id":179,"createTime":21,"updateTime":21,"relativeEntities":876,"label":877,"description":878,"key":185,"publicationTags":879,"standard":21},[],{"EN":182,"VI":182},{"EN":184,"VI":184},[187],"https:\u002F\u002Fasean-cites.org\u002Fjournal_info?jid=10629","2016-2022",[883],"e04f14cf-280b-4aa8-b711-b77ddd79cbaf",{"id":885,"indexDatabase":886,"url":897,"indexYears":21,"academicFieldIds":898,"indexDatabaseRanking":21},"06f278ee-37b9-41eb-a9b0-3d2d77fa502b",{"id":887,"createTime":21,"updateTime":21,"relativeEntities":888,"label":889,"description":891,"key":894,"publicationTags":895,"standard":21},"88bab0f7-443b-476c-a72a-7fa5222da393",[],{"EN":890,"VI":890},"ISI\u002FESCI  - 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Native to the Korean Peninsula, Japan, and Dokdo Island in the Sea of Japan, it is the only fern present on Dokdo Island. We isolated and characterized the chloroplast (cp) genome of C. falcatum, and compared it with those of closely related species. The genes trnV-GAC and trnV-GAU were found to be present within the cp genome of C. falcatum, whereas trnP-GGG and rpl21 were lacking. Moreover, cp genomes of Cyrtomium devexiscapulae and Adiantum capillus-veneris lack trnP-GGG and rpl21, suggesting these are not conserved among angiosperm cp genomes. The deletion of trnR-UCG, trnR-CCG, and trnSeC in the cp genomes of C. falcatum and other eupolypod ferns indicates these genes are restricted to tree ferns, non-core leptosporangiates, and basal ferns. The C. falcatum cp genome also encoded ndhF and rps7, with GUG start codons that were only conserved in polypod ferns, and it shares two significant inversions with other ferns, including a minor inversion of the trnD-GUC region and an approximate 3 kb inversion of the trnG-trnT region. Phylogenetic analyses showed that Equisetum was found to be a sister clade to Psilotales-Ophioglossales with a 100% bootstrap (BS) value. The sister relationship between Pteridaceae and eupolypods was also strongly supported by a 100% BS, but Bayesian molecular clock analyses suggested that C. falcatum diversified in the mid-Paleogene period (45.15 ± 4.93 million years ago) and might have moved from Eurasia to Dokdo Island.","PUBLICATION","Author affiliation is blank",[125],"http:\u002F\u002Fwww.mdpi.com\u002F2073-4425\u002F7\u002F12\u002F115","https:\u002F\u002Fwww.mdpi.com\u002F2073-4425\u002F7\u002F12\u002F115\u002Fpdf?version=1481536912",[970,977,984],{"id":971,"sortIndex":22,"researcher":21,"roles":972,"affiliations":973,"properties":974,"displayName":976,"givenName":21,"familyName":21},"0ada5ad9-214b-4988-8916-9d18db7c554c",[],[],{"title":975},{"EN":976},"Raman, Gurusamy",{"id":978,"sortIndex":93,"researcher":21,"roles":979,"affiliations":980,"properties":981,"displayName":983,"givenName":21,"familyName":21},"235eef2d-2905-4661-b018-c1244ca67bdb",[],[],{"title":982},{"EN":983},"Choi, Kyoung Su",{"id":985,"sortIndex":214,"researcher":21,"roles":986,"affiliations":987,"properties":988,"displayName":990,"givenName":21,"familyName":21},"cd4ac4f5-4a40-417b-9c1f-15941cb1f856",[],[],{"title":989},{"EN":990},"Park, SeonJoo","ARTICLE",{"url":21,"publisher":993,"properties":1039},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":994,"slug":10,"properties":995,"entityType":19,"verifyStatus":20,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":22,"subjectFields":999,"manageAffiliations":1008,"indexDatabases":1019,"url":87,"thumbnailPath":21,"statistic":1034,"gsStatistic":21,"type":21,"analyzePriority":21},[],{"issn":996,"title":997,"country":998},{"VOID":15},{"EN":10},{"VOID":13},[1000,1004],{"id":25,"createTime":21,"updateTime":21,"relativeEntities":1001,"label":1002,"description":1003,"parentId":21,"standard":21,"scholarHubFieldId":21},[],{"EN":28},{},{"id":31,"createTime":21,"updateTime":21,"relativeEntities":1005,"label":1006,"description":1007,"parentId":21,"standard":21,"scholarHubFieldId":21},[],{"EN":34},{},[1009,1014],{"id":38,"createTime":21,"updateTime":21,"relativeEntities":1010,"slug":21,"properties":1011,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":1013,"statistic":21},[],{"title":1012},{"EN":42},[],{"id":45,"createTime":21,"updateTime":21,"relativeEntities":1015,"slug":21,"properties":1016,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":1018,"statistic":21},[],{"title":1017},{"EN":49},[],[1020,1027],{"id":53,"indexDatabase":1021,"url":64,"indexYears":65,"academicFieldIds":1026,"indexDatabaseRanking":69},{"id":55,"createTime":21,"updateTime":21,"relativeEntities":1022,"label":1023,"description":1024,"key":61,"publicationTags":1025,"standard":21},[],{"EN":58,"VI":58},{"EN":58,"VI":60},[63],[67,68],{"id":71,"indexDatabase":1028,"url":84,"indexYears":21,"academicFieldIds":1033,"indexDatabaseRanking":21},{"id":73,"createTime":21,"updateTime":21,"relativeEntities":1029,"label":1030,"description":1031,"key":80,"publicationTags":1032,"standard":21},[],{"EN":76,"VI":76},{"EN":78,"VI":79},[82,83],[86],{"impactFactor":22,"impactFactorByYear":1035,"i10Index":90,"i10IndexLast5Year":22,"totalPublication":91,"totalPublicationByYear":1036,"totalCitation":94,"totalCitationByYear":1037,"totalCitationPerPublication":96,"totalCitationPerPublicationByYear":1038,"hindexLast5Year":98,"hindex":98},{},{"2016":93},{},{},{"issue":1040,"pages":1042,"volume":1044},{"VOID":1041},"12",{"VOID":1043},"115",{"VOID":1045},"7","2016-12-01",2016,[69,82],[],false,{"id":1052,"createTime":1053,"updateTime":1053,"relativeEntities":1054,"slug":1055,"properties":1056,"entityType":964,"verifyStatus":121,"verifyTime":1053,"verifyNote":1071,"languages":1072,"translateLanguages":21,"viewCount":22,"primaryUrl":1073,"fullTextUrl":21,"authors":1074,"publicationType":991,"publisherRelationship":1274,"citationCount":1328,"citationInfo":1329,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":1331,"openAccess":21,"references":1332,"isForceReanalyzing":1050},"3bc124b0-7602-4781-b6d7-94291b851ecc","2024-10-06T00:38:57.956+00:00",[],"MYC-Deregulation-in-Primary-Human-Cancers",{"mag":1057,"pmc":1059,"openalex":1061,"abstract":1063,"title":1065,"pm":1067,"doi":1069},{"VOID":1058},"2618573553",{"VOID":1060},"5485515",{"VOID":1062},"W2618573553",{"EN":1064},"\u003Cjats:p>MYC regulates a complex biological program by transcriptionally activating and repressing its numerous target genes. As such, MYC is a master regulator of many processes, including cell cycle entry, ribosome biogenesis, and metabolism. In cancer, the activity of the MYC transcriptional network is frequently deregulated, contributing to the initiation and maintenance of disease. Deregulation often leads to constitutive overexpression of MYC, which can be achieved through gross genetic abnormalities, including copy number alterations, chromosomal translocations, increased enhancer activity, or through aberrant signal transduction leading to increased MYC transcription or increased MYC mRNA and protein stability. Herein, we summarize the frequency and modes of MYC deregulation and describe both well-established and more recent findings in a variety of cancer types. 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Biol., 13, 882, 10.1016\u002FS0960-9822(03)00297-5",{"doi":1348},"10.1016\u002FS0960-9822(03)00297-5",{"id":21,"text":1350,"url":21,"identifiers":1351},"Mateyak, 1997, Phenotypes of c-MYC-deficient rat fibroblasts isolated by targeted homologous recombination, Cell Growth Differ., 8, 1039",{},{"id":21,"text":1353,"url":21,"identifiers":1354},"Meyer, 2008, Reflecting on 25 years with MYC, Nat. Rev. Cancer, 8, 976, 10.1038\u002Fnrc2231",{"doi":1355},"10.1038\u002Fnrc2231",{"id":21,"text":1357,"url":21,"identifiers":1358},"Kelly, 1983, Cell-specific regulation of the c-MYC gene by lymphocyte mitogens and platelet-derived growth factor, Cell, 35, 603, 10.1016\u002F0092-8674(83)90092-2",{"doi":1359},"10.1016\u002F0092-8674(83)90092-2",{"id":21,"text":1361,"url":21,"identifiers":1362},"Eberhardy, 2001, C-MYC mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism, J. Biol. Chem., 276, 48562, 10.1074\u002Fjbc.M109014200",{"doi":1363},"10.1074\u002Fjbc.M109014200",{"id":21,"text":1365,"url":21,"identifiers":1366},"Eberhardy, 2002, MYC recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter, J. Biol. Chem., 277, 40156, 10.1074\u002Fjbc.M207441200",{"doi":1367},"10.1074\u002Fjbc.M207441200",{"id":21,"text":1369,"url":21,"identifiers":1370},"Rahl, 2010, C-MYC regulates transcriptional pause release, Cell, 141, 432, 10.1016\u002Fj.cell.2010.03.030",{"doi":1371},"10.1016\u002Fj.cell.2010.03.030",{"id":21,"text":1373,"url":21,"identifiers":1374},"Cowling, 2010, MYC regulation of mRNA cap methylation, Genes Cancer, 1, 576, 10.1177\u002F1947601910378025",{"doi":1375},"10.1177\u002F1947601910378025",{"id":21,"text":1377,"url":21,"identifiers":1378},"Cowling, 2007, The MYC transactivation domain promotes global phosphorylation of the RNA polymerase II carboxy-terminal domain independently of direct DNA binding, Mol. Cell. Biol., 27, 2059, 10.1128\u002FMCB.01828-06",{"doi":1379},"10.1128\u002FMCB.01828-06",{"id":21,"text":1381,"url":21,"identifiers":1382},"Lin, 2012, Transcriptional amplification in tumor cells with elevated c-MYC, Cell, 151, 56, 10.1016\u002Fj.cell.2012.08.026",{"doi":1383},"10.1016\u002Fj.cell.2012.08.026",{"id":21,"text":1385,"url":21,"identifiers":1386},"Henriksson, 1993, Phosphorylation sites mapping in the N-terminal domain of c-MYC modulate its transforming potential, Oncogene, 8, 3199",{},{"id":21,"text":1388,"url":21,"identifiers":1389},"Lutterbach, 1994, Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-MYC protein is regulated by mitogens and in mitosis, Mol. Cell. Biol., 14, 5510",{},{"id":21,"text":1391,"url":21,"identifiers":1392},"Hasmall, 1997, Expression of the immediate-early genes, c-FOS, c-JUN, and c-MYC: A comparison in rats of nongenotoxic hepatocarcinogens with noncarcinogenic liver mitogens, Fundam. Appl. Toxicol., 40, 129, 10.1006\u002Ffaat.1997.2371",{"doi":1393},"10.1006\u002Ffaat.1997.2371",{"id":21,"text":1395,"url":21,"identifiers":1396},"Beroukhim, 2010, The landscape of somatic copy-number alteration across human cancers, Nature, 463, 899, 10.1038\u002Fnature08822",{"doi":1397},"10.1038\u002Fnature08822",{"id":21,"text":1399,"url":21,"identifiers":1400},"Ciriello, 2013, Emerging landscape of oncogenic signatures across human cancers, Nat. Genet., 45, 1127, 10.1038\u002Fng.2762",{"doi":1401},"10.1038\u002Fng.2762",{"id":21,"text":1403,"url":21,"identifiers":1404},"Burrell, 2013, The causes and consequences of genetic heterogeneity in cancer evolution, Nature, 501, 338, 10.1038\u002Fnature12625",{"doi":1405},"10.1038\u002Fnature12625",{"id":21,"text":1407,"url":21,"identifiers":1408},"Collins, 1982, Amplification of endogenous MYC-related DNA sequences in a human myeloid leukaemia cell line, Nature, 298, 679, 10.1038\u002F298679a0",{"doi":1409},"10.1038\u002F298679a0",{"id":21,"text":1411,"url":21,"identifiers":1412},"Schwab, 1983, Amplified DNA with limited homology to MYC cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour, Nature, 305, 245, 10.1038\u002F305245a0",{"doi":1413},"10.1038\u002F305245a0",{"id":21,"text":1415,"url":21,"identifiers":1416},"Nau, 1985, L-MYC, a new MYC-related gene amplified and expressed in human small cell lung cancer, Nature, 318, 69, 10.1038\u002F318069a0",{"doi":1417},"10.1038\u002F318069a0",{"id":21,"text":1419,"url":21,"identifiers":1420},"Little, 1983, Amplification and expression of the c-MYC oncogene in human lung cancer cell lines, Nature, 306, 194, 10.1038\u002F306194a0",{"doi":1421},"10.1038\u002F306194a0",{"id":21,"text":1423,"url":21,"identifiers":1424},"Nau, 1986, Human small-cell lung cancers show amplification and expression of the N-myc gene, Proc. Natl. Acad. Sci. USA, 83, 1092, 10.1073\u002Fpnas.83.4.1092",{"doi":1425},"10.1073\u002Fpnas.83.4.1092",{"id":21,"text":1427,"url":21,"identifiers":1428},"Nakagawa, 2015, Cancer whole-genome sequencing: Present and future, Oncogene, 34, 5943, 10.1038\u002Fonc.2015.90",{"doi":1429},"10.1038\u002Fonc.2015.90",{"id":21,"text":1431,"url":21,"identifiers":1432},"Tomczak, 2015, The cancer genome atlas (TCGA): An immeasurable source of knowledge, Contemp. Oncol., 19, A68",{},{"id":21,"text":1434,"url":21,"identifiers":1435},"International Cancer Genome Consortium, Hudson, T.J., Anderson, W., Artez, A., Barker, A.D., Bell, C., Bernabe, R.R., Bhan, M.K., Calvo, F., and Eerola, I. (2010). International network of cancer genome projects. Nature, 464, 993–998.",{"doi":1436},"10.1038\u002Fnature08987",{"id":21,"text":1438,"url":21,"identifiers":1439},"Zack, 2013, Pan-cancer patterns of somatic copy number alteration, Nat. Genet., 45, 1134, 10.1038\u002Fng.2760",{"doi":1440},"10.1038\u002Fng.2760",{"id":21,"text":1442,"url":21,"identifiers":1443},"Curtis, 2012, The genomic and transcriptomic architecture of 2000 breast tumours reveals novel subgroups, Nature, 486, 346, 10.1038\u002Fnature10983",{"doi":1444},"10.1038\u002Fnature10983",{"id":21,"text":1446,"url":21,"identifiers":1447},"Cancer Genome Atlas Network (2012). Comprehensive molecular portraits of human breast tumours. Nature, 490, 61–70.",{"doi":1448},"10.1038\u002Fnature11412",{"id":21,"text":1450,"url":21,"identifiers":1451},"Balko, 2014, Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets, Cancer Discov., 4, 232, 10.1158\u002F2159-8290.CD-13-0286",{"doi":1452},"10.1158\u002F2159-8290.CD-13-0286",{"id":21,"text":1454,"url":21,"identifiers":1455},"Cancer Genome Atlas Research Network (2011). Integrated genomic analyses of ovarian carcinoma. Nature, 474, 609–615.",{"doi":1456},"10.1038\u002Fnature10166",{"id":21,"text":1458,"url":21,"identifiers":1459},"Murthy, 1990, Characterization of a solubilized malonyl-CoA-sensitive carnitine palmitoyltransferase from the mitochondrial outer membrane as a protein distinct from the malonyl-CoA-insensitive carnitine palmitoyltransferase of the inner membrane, Biochem. J., 268, 599, 10.1042\u002Fbj2680599",{"doi":1460},"10.1042\u002Fbj2680599",{"id":21,"text":1462,"url":21,"identifiers":1463},"Cerami, 2012, The cbio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data, Cancer Discov., 2, 401, 10.1158\u002F2159-8290.CD-12-0095",{"doi":1464},"10.1158\u002F2159-8290.CD-12-0095",{"id":21,"text":1466,"url":21,"identifiers":1467},"Gao, 2013, Integrative analysis of complex cancer genomics and clinical profiles using the cbioportal, Sci. Signal., 6, pl1, 10.1126\u002Fscisignal.2004088",{"doi":1468},"10.1126\u002Fscisignal.2004088",{"id":21,"text":1470,"url":21,"identifiers":1471},"Beltran, 2016, Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer, Nat. Medic., 22, 298, 10.1038\u002Fnm.4045",{"doi":1472},"10.1038\u002Fnm.4045",{"id":21,"text":1474,"url":21,"identifiers":1475},"Northcott, 2012, Subgroup-specific structural variation across 1,000 medulloblastoma genomes, Nature, 488, 49, 10.1038\u002Fnature11327",{"doi":1476},"10.1038\u002Fnature11327",{"id":21,"text":1478,"url":21,"identifiers":1479},"Robinson, 2015, Integrative clinical genomics of advanced prostate cancer, Cell, 161, 1215, 10.1016\u002Fj.cell.2015.05.001",{"doi":1480},"10.1016\u002Fj.cell.2015.05.001",{"id":21,"text":1482,"url":21,"identifiers":1483},"Guinney, 2015, The consensus molecular subtypes of colorectal cancer, Nat. Med., 21, 1350, 10.1038\u002Fnm.3967",{"doi":1484},"10.1038\u002Fnm.3967",{"id":21,"text":1486,"url":21,"identifiers":1487},"Cancer Genome Atlas Network (2012). Comprehensive molecular characterization of human colon and rectal cancer. Nature, 487, 330–337.",{"doi":1488},"10.1038\u002Fnature11252",{"id":21,"text":1490,"url":21,"identifiers":1491},"Seshagiri, 2012, Recurrent R-spondin fusions in colon cancer, Nature, 488, 660, 10.1038\u002Fnature11282",{"doi":1492},"10.1038\u002Fnature11282",{"id":21,"text":1494,"url":21,"identifiers":1495},"He, 1998, Identification of c-MYC as a target of the APC pathway, Science, 281, 1509, 10.1126\u002Fscience.281.5382.1509",{"doi":1496},"10.1126\u002Fscience.281.5382.1509",{"id":21,"text":1498,"url":21,"identifiers":1499},"Yada, 2004, Phosphorylation-dependent degradation of c-MYC is mediated by the F-box protein FBW7, EMBO J., 23, 2116, 10.1038\u002Fsj.emboj.7600217",{"doi":1500},"10.1038\u002Fsj.emboj.7600217",{"id":21,"text":1502,"url":21,"identifiers":1503},"Welcker, 2004, The FBW7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-MYC protein degradation, Proc. Natl. Acad. Sci. USA, 101, 9085, 10.1073\u002Fpnas.0402770101",{"doi":1504},"10.1073\u002Fpnas.0402770101",{"id":21,"text":1506,"url":21,"identifiers":1507},"Calonge, 1999, SMAD4\u002FDPC4 silencing and hyperactive ras jointly disrupt transforming growth factor-β antiproliferative responses in colon cancer cells, J. Biol. Chem., 274, 33637, 10.1074\u002Fjbc.274.47.33637",{"doi":1508},"10.1074\u002Fjbc.274.47.33637",{"id":21,"text":1510,"url":21,"identifiers":1511},"Seoane, 2001, TGFβ influences Myc, Miz-1 and smad to control the CDK inhibitor p15INK4b, Nat. Cell Biol., 3, 400, 10.1038\u002F35070086",{"doi":1512},"10.1038\u002F35070086",{"id":21,"text":1514,"url":21,"identifiers":1515},"Nagl, 2006, The c-MYC gene is a direct target of mammalian SWI\u002FSNF-related complexes during differentiation-associated cell cycle arrest, Cancer Res., 66, 1289, 10.1158\u002F0008-5472.CAN-05-3427",{"doi":1516},"10.1158\u002F0008-5472.CAN-05-3427",{"id":21,"text":1518,"url":21,"identifiers":1519},"Cancer Genome Atlas Research Network (2015). The molecular taxonomy of primary prostate cancer. Cell, 163, 1011–1025.",{},{"id":21,"text":1521,"url":21,"identifiers":1522},"Fraser, 2017, Genomic hallmarks of localized, non-indolent prostate cancer, Nature, 541, 359, 10.1038\u002Fnature20788",{"doi":1523},"10.1038\u002Fnature20788",{"id":21,"text":1525,"url":21,"identifiers":1526},"Scher, 2012, Increased survival with enzalutamide in prostate cancer after chemotherapy, N. Engl. J. Med., 367, 1187, 10.1056\u002FNEJMoa1207506",{"doi":1527},"10.1056\u002FNEJMoa1207506",{"id":21,"text":1529,"url":21,"identifiers":1530},"Berruti, 2011, Abiraterone and increased survival in metastatic prostate cancer, N. Engl. J. Med., 365, 766, 10.1056\u002FNEJMc1107198",{"doi":1531},"10.1056\u002FNEJMc1107198",{"id":21,"text":1533,"url":21,"identifiers":1534},"Sutherland, 2010, Cell of origin of lung cancer, Mol. Oncol., 4, 397, 10.1016\u002Fj.molonc.2010.05.002",{"doi":1535},"10.1016\u002Fj.molonc.2010.05.002",{"id":21,"text":1537,"url":21,"identifiers":1538},"Cancer Genome Atlas Research Network (2012). Comprehensive genomic characterization of squamous cell lung cancers. Nature, 489, 519–525.",{"doi":1539},"10.1038\u002Fnature11404",{"id":21,"text":1541,"url":21,"identifiers":1542},"Imielinski, 2012, Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing, Cell, 150, 1107, 10.1016\u002Fj.cell.2012.08.029",{"doi":1543},"10.1016\u002Fj.cell.2012.08.029",{"id":21,"text":1545,"url":21,"identifiers":1546},"Cancer Genome Atlas Research Network (2014). Comprehensive molecular profiling of lung adenocarcinoma. Nature, 511, 543–550.",{"doi":1547},"10.1038\u002Fnature13385",{"id":21,"text":1549,"url":21,"identifiers":1550},"Bailey, 2016, Genomic analyses identify molecular subtypes of pancreatic cancer, Nature, 531, 47, 10.1038\u002Fnature16965",{"doi":1551},"10.1038\u002Fnature16965",{"id":21,"text":1553,"url":21,"identifiers":1554},"Witkiewicz, 2015, Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets, Nat. Commun., 6, 6744, 10.1038\u002Fncomms7744",{"doi":1555},"10.1038\u002Fncomms7744",{"id":21,"text":1557,"url":21,"identifiers":1558},"Sato, 2013, Integrated molecular analysis of clear-cell renal cell carcinoma, Nat. Genet., 45, 860, 10.1038\u002Fng.2699",{"doi":1559},"10.1038\u002Fng.2699",{"id":21,"text":1561,"url":21,"identifiers":1562},"Cancer Genome Atlas Research Network (2013). Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature, 499, 43–49.",{"doi":1563},"10.1038\u002Fnature12222",{"id":21,"text":1565,"url":21,"identifiers":1566},"Northcott, 2011, Medulloblastoma comprises four distinct molecular variants, J. Clin. Oncol., 29, 1408, 10.1200\u002FJCO.2009.27.4324",{"doi":1567},"10.1200\u002FJCO.2009.27.4324",{"id":21,"text":1569,"url":21,"identifiers":1570},"Robinson, 2012, Novel mutations target distinct subgroups of medulloblastoma, Nature, 488, 43, 10.1038\u002Fnature11213",{"doi":1571},"10.1038\u002Fnature11213",{"id":21,"text":1573,"url":21,"identifiers":1574},"Pugh, 2012, Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations, Nature, 488, 106, 10.1038\u002Fnature11329",{"doi":1575},"10.1038\u002Fnature11329",{"id":21,"text":1577,"url":21,"identifiers":1578},"Jones, 2012, Dissecting the genomic complexity underlying medulloblastoma, Nature, 488, 100, 10.1038\u002Fnature11284",{"doi":1579},"10.1038\u002Fnature11284",{"id":21,"text":1581,"url":21,"identifiers":1582},"Lin, 2016, Active medulloblastoma enhancers reveal subgroup-specific cellular origins, Nature, 530, 57, 10.1038\u002Fnature16546",{"doi":1583},"10.1038\u002Fnature16546",{"id":21,"text":1585,"url":21,"identifiers":1586},"Swartling, 2012, Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC, Cancer Cell, 21, 601, 10.1016\u002Fj.ccr.2012.04.012",{"doi":1587},"10.1016\u002Fj.ccr.2012.04.012",{"id":21,"text":1589,"url":21,"identifiers":1590},"Kawauchi, 2012, A mouse model of the most aggressive subgroup of human medulloblastoma, Cancer Cell, 21, 168, 10.1016\u002Fj.ccr.2011.12.023",{"doi":1591},"10.1016\u002Fj.ccr.2011.12.023",{"id":21,"text":1593,"url":21,"identifiers":1594},"Wu, 2012, Clonal selection drives genetic divergence of metastatic medulloblastoma, Nature, 482, 529, 10.1038\u002Fnature10825",{"doi":1595},"10.1038\u002Fnature10825",{"id":21,"text":1597,"url":21,"identifiers":1598},"Hill, 2015, Combined MYC and p53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease, Cancer Cell, 27, 72, 10.1016\u002Fj.ccell.2014.11.002",{"doi":1599},"10.1016\u002Fj.ccell.2014.11.002",{"id":21,"text":1601,"url":21,"identifiers":1602},"Morrissy, 2016, Divergent clonal selection dominates medulloblastoma at recurrence, Nature, 529, 351, 10.1038\u002Fnature16478",{"doi":1603},"10.1038\u002Fnature16478",{"id":21,"text":1605,"url":21,"identifiers":1606},"Brodeur, 1984, Amplification of N-MYC in untreated human neuroblastomas correlates with advanced disease stage, Science, 224, 1121, 10.1126\u002Fscience.6719137",{"doi":1607},"10.1126\u002Fscience.6719137",{"id":21,"text":1609,"url":21,"identifiers":1610},"Schleiermacher, 2009, Overall genomic pattern is a predictor of outcome in neuroblastoma, J. Clin. Oncol., 27, 1026, 10.1200\u002FJCO.2008.16.0630",{"doi":1611},"10.1200\u002FJCO.2008.16.0630",{"id":21,"text":1613,"url":21,"identifiers":1614},"Westermann, 2008, Distinct transcriptional MYCN\u002Fc-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas, Genome Biol., 9, R150, 10.1186\u002Fgb-2008-9-10-r150",{"doi":1615},"10.1186\u002Fgb-2008-9-10-r150",{"id":21,"text":1617,"url":21,"identifiers":1618},"Pugh, 2013, The genetic landscape of high-risk neuroblastoma, Nat. Genet., 45, 279, 10.1038\u002Fng.2529",{"doi":1619},"10.1038\u002Fng.2529",{"id":21,"text":1621,"url":21,"identifiers":1622},"Molenaar, 2012, Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes, Nature, 483, 589, 10.1038\u002Fnature10910",{"doi":1623},"10.1038\u002Fnature10910",{"id":21,"text":1625,"url":21,"identifiers":1626},"Peifer, 2015, Telomerase activation by genomic rearrangements in high-risk neuroblastoma, Nature, 526, 700, 10.1038\u002Fnature14980",{"doi":1627},"10.1038\u002Fnature14980",{"id":21,"text":1629,"url":21,"identifiers":1630},"Blackwood, 1991, MAX: A helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with MYC, Science, 251, 1211, 10.1126\u002Fscience.2006410",{"doi":1631},"10.1126\u002Fscience.2006410",{"id":21,"text":1633,"url":21,"identifiers":1634},"Ribon, 1994, C-MYC does not require MAX for transcriptional activity in PC-12 cells, Mol. Cell. Neurosci., 5, 277, 10.1006\u002Fmcne.1994.1032",{"doi":1635},"10.1006\u002Fmcne.1994.1032",{"id":21,"text":1637,"url":21,"identifiers":1638},"Hopewell, 1995, The nerve growth factor-responsive PC12 cell line does not express the MYC dimerization partner MAX, Mol. Cell. Biol., 15, 3470, 10.1128\u002FMCB.15.7.3470",{"doi":1639},"10.1128\u002FMCB.15.7.3470",{"id":21,"text":1641,"url":21,"identifiers":1642},"Schiavi, 2011, Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma, Nat. Genet., 43, 663, 10.1038\u002Fng.861",{"doi":1643},"10.1038\u002Fng.861",{"id":21,"text":1645,"url":21,"identifiers":1646},"Fishbein, 2017, Comprehensive molecular characterization of pheochromocytoma and paraganglioma, Cancer Cell, 31, 181, 10.1016\u002Fj.ccell.2017.01.001",{"doi":1647},"10.1016\u002Fj.ccell.2017.01.001",{"id":21,"text":1649,"url":21,"identifiers":1650},"Romero, 2014, MAX inactivation in small cell lung cancer disrupts MYC-SWI\u002FSNF programs and is synthetic lethal with BRG1, Cancer Discov., 4, 292, 10.1158\u002F2159-8290.CD-13-0799",{"doi":1651},"10.1158\u002F2159-8290.CD-13-0799",{"id":21,"text":1653,"url":21,"identifiers":1654},"Kamoun, 2016, Integrated multi-omics analysis of oligodendroglial tumours identifies three subgroups of 1p\u002F19q co-deleted gliomas, Nat. Commun., 7, 11263, 10.1038\u002Fncomms11263",{"doi":1655},"10.1038\u002Fncomms11263",{"id":21,"text":1657,"url":21,"identifiers":1658},"Turner, 2017, Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity, Nature, 543, 122, 10.1038\u002Fnature21356",{"doi":1659},"10.1038\u002Fnature21356",{"id":21,"text":1661,"url":21,"identifiers":1662},"Escot, 1986, Genetic alteration of the c-MYC protooncogene (MYC) in human primary breast carcinomas, Proc. Natl. Acad. Sci. USA, 83, 4834, 10.1073\u002Fpnas.83.13.4834",{"doi":1663},"10.1073\u002Fpnas.83.13.4834",{"id":21,"text":1665,"url":21,"identifiers":1666},"Escot, 1988, In situ c-MYC expression and genomic status of the c-MYC locus in infiltrating ductal carcinomas of the breast, Cancer Res., 48, 199",{},{"id":21,"text":1668,"url":21,"identifiers":1669},"Slavc, 1990, MYC gene amplification and expression in primary human neuroblastoma, Cancer Res., 50, 1459",{},{"id":21,"text":1671,"url":21,"identifiers":1672},"Weng, 2006, C-MYC is an important direct target of NOTCH1 in T-cell acute lymphoblastic leukemia\u002Flymphoma, Genes Dev., 20, 2096, 10.1101\u002Fgad.1450406",{"doi":1673},"10.1101\u002Fgad.1450406",{"id":21,"text":1675,"url":21,"identifiers":1676},"Sears, 2000, Multiple RAS-dependent phosphorylation pathways regulate MYC protein stability, Genes Dev., 14, 2501, 10.1101\u002Fgad.836800",{"doi":1677},"10.1101\u002Fgad.836800",{"id":21,"text":1679,"url":21,"identifiers":1680},"Tseng, 2014, PVT1 dependence in cancer with MYC copy-number increase, Nature, 512, 82, 10.1038\u002Fnature13311",{"doi":1681},"10.1038\u002Fnature13311",{"id":21,"text":1683,"url":21,"identifiers":1684},"Ulz, 2016, Co-occurrence of MYC amplification and TP53 mutations in human cancer, Nat. Genet., 48, 104, 10.1038\u002Fng.3468",{"doi":1685},"10.1038\u002Fng.3468",{"id":21,"text":1687,"url":21,"identifiers":1688},"Pascale, 1996, C-MYC amplification in pre-malignant and malignant lesions induced in rat liver by the resistant hepatocyte model, Int. J. Cancer, 68, 136, 10.1002\u002F(SICI)1097-0215(19960927)68:1\u003C136::AID-IJC24>3.0.CO;2-8",{"doi":1689},"10.1002\u002F(SICI)1097-0215(19960927)68:1\u003C136::AID-IJC24>3.0.CO;2-8",{"id":21,"text":1691,"url":21,"identifiers":1692},"Murphy, 2008, Distinct thresholds govern MYC’s biological output in vivo, Cancer Cell, 14, 447, 10.1016\u002Fj.ccr.2008.10.018",{"doi":1693},"10.1016\u002Fj.ccr.2008.10.018",{"id":21,"text":1695,"url":21,"identifiers":1696},"Fernandez, 2003, Genomic targets of the human c-MYC protein, Genes Dev., 17, 1115, 10.1101\u002Fgad.1067003",{"doi":1697},"10.1101\u002Fgad.1067003",{"id":21,"text":1699,"url":21,"identifiers":1700},"Kim, J., Lee, J.H., and Iyer, V.R. (2008). Global identification of MYC target genes reveals its direct role in mitochondrial biogenesis and its E-box usage in vivo. PLoS ONE, 3.",{"doi":1701},"10.1371\u002Fjournal.pone.0001798",{"id":21,"text":1703,"url":21,"identifiers":1704},"Shim, 1997, MYC target genes in neoplastic transformation, Curr. Top. Microbiol. Immunol., 224, 181",{},{"id":21,"text":1706,"url":21,"identifiers":1707},"Dang, 1999, C-MYC target genes involved in cell growth, apoptosis, and metabolism, Mol. Cell. Biol., 19, 1, 10.1128\u002FMCB.19.1.1",{"doi":1708},"10.1128\u002FMCB.19.1.1",{"id":21,"text":1710,"url":21,"identifiers":1711},"Molyneux, 2012, Burkitt’s lymphoma, Lancet, 379, 1234, 10.1016\u002FS0140-6736(11)61177-X",{"doi":1712},"10.1016\u002FS0140-6736(11)61177-X",{"id":21,"text":1714,"url":21,"identifiers":1715},"Bregni, 1982, Human c-MYC onc gene is located on the region of chromosome 8 that is translocated in burkitt lymphoma cells, Proc. Natl. Acad. Sci. USA, 79, 7824, 10.1073\u002Fpnas.79.24.7824",{"doi":1716},"10.1073\u002Fpnas.79.24.7824",{"id":21,"text":1718,"url":21,"identifiers":1719},"Epstein, 1977, Chromosome 14 translocation in african and north american burkitt’s lymphoma, Int. J. Cancer, 19, 482, 10.1002\u002Fijc.2910190408",{"doi":1720},"10.1002\u002Fijc.2910190408",{"id":21,"text":1722,"url":21,"identifiers":1723},"Taub, 1982, Translocation of the c-MYC gene into the immunoglobulin heavy chain locus in human burkitt lymphoma and murine plasmacytoma cells, Proc. Natl. Acad. Sci. USA, 79, 7837, 10.1073\u002Fpnas.79.24.7837",{"doi":1724},"10.1073\u002Fpnas.79.24.7837",{"id":21,"text":1726,"url":21,"identifiers":1727},"Marcu, 1983, Transcriptionally active c-MYC oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia, Proc. Natl. Acad. Sci. USA, 80, 519, 10.1073\u002Fpnas.80.2.519",{"doi":1728},"10.1073\u002Fpnas.80.2.519",{"id":21,"text":1730,"url":21,"identifiers":1731},"Chng, 2011, Clinical and biological implications of MYC activation: A common difference between MGUS and newly diagnosed multiple myeloma, Leukemia, 25, 1026, 10.1038\u002Fleu.2011.53",{"doi":1732},"10.1038\u002Fleu.2011.53",{"id":21,"text":1734,"url":21,"identifiers":1735},"Mitsiades, 2004, Focus on multiple myeloma, Cancer Cell, 6, 439, 10.1016\u002Fj.ccr.2004.10.020",{"doi":1736},"10.1016\u002Fj.ccr.2004.10.020",{"id":21,"text":1738,"url":21,"identifiers":1739},"Stewart, 2005, Prognostic and therapeutic significance of myeloma genetics and gene expression profiling, J. Clin. Oncol., 23, 6339, 10.1200\u002FJCO.2005.05.023",{"doi":1740},"10.1200\u002FJCO.2005.05.023",{"id":21,"text":1742,"url":21,"identifiers":1743},"Singhal, 2006, Multiple myeloma, Clin. J. Am. Soc. Nephrol., 1, 1322, 10.2215\u002FCJN.03060906",{"doi":1744},"10.2215\u002FCJN.03060906",{"id":21,"text":1746,"url":21,"identifiers":1747},"Dib, A., Gabrea, A., Glebov, O.K., Bergsagel, P.L., and Kuehl, W.M. (2008). Characterization of MYC translocations in multiple myeloma cell lines. J. Natl. Cancer Inst. Monogr., 25–31.",{"doi":1748},"10.1093\u002Fjncimonographs\u002Flgn011",{"id":21,"text":1750,"url":21,"identifiers":1751},"Jimenez, 2017, A next-generation sequencing strategy for evaluating the most common genetic abnormalities in multiple myeloma, J. Mol. Diagn., 19, 99, 10.1016\u002Fj.jmoldx.2016.08.004",{"doi":1752},"10.1016\u002Fj.jmoldx.2016.08.004",{"id":21,"text":1754,"url":21,"identifiers":1755},"Grisanzio, 2010, Chromosome 8q24-associated cancers and MYC, Genes Cancer, 1, 555, 10.1177\u002F1947601910381380",{"doi":1756},"10.1177\u002F1947601910381380",{"id":21,"text":1758,"url":21,"identifiers":1759},"Easton, 2008, Genome-wide association studies in cancer, Hum. Mol. Genet., 17, R109, 10.1093\u002Fhmg\u002Fddn287",{"doi":1760},"10.1093\u002Fhmg\u002Fddn287",{"id":21,"text":1762,"url":21,"identifiers":1763},"Zhang, 2016, Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers, Nat. Genet., 48, 176, 10.1038\u002Fng.3470",{"doi":1764},"10.1038\u002Fng.3470",{"id":21,"text":1766,"url":21,"identifiers":1767},"Stone, 2015, DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer, Nat. Commun., 6, 7758, 10.1038\u002Fncomms8758",{"doi":1768},"10.1038\u002Fncomms8758",{"id":21,"text":1770,"url":21,"identifiers":1771},"Heyn, 2016, Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer, Genome Biol., 17, 11, 10.1186\u002Fs13059-016-0879-2",{"doi":1772},"10.1186\u002Fs13059-016-0879-2",{"id":21,"text":1774,"url":21,"identifiers":1775},"Corradin, 2014, Enhancer variants: Evaluating functions in common disease, Genome Med., 6, 85, 10.1186\u002Fs13073-014-0085-3",{"doi":1776},"10.1186\u002Fs13073-014-0085-3",{"id":21,"text":1778,"url":21,"identifiers":1779},"Wright, 2010, Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells, Mol. Cell. Biol., 30, 1411, 10.1128\u002FMCB.01384-09",{"doi":1780},"10.1128\u002FMCB.01384-09",{"id":21,"text":1782,"url":21,"identifiers":1783},"Ahmadiyeh, 2010, 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC, Proc. Natl. Acad. Sci. USA, 107, 9742, 10.1073\u002Fpnas.0910668107",{"doi":1784},"10.1073\u002Fpnas.0910668107",{"id":21,"text":1786,"url":21,"identifiers":1787},"Haiman, 2007, Multiple regions within 8q24 independently affect risk for prostate cancer, Nat. Genet., 39, 638, 10.1038\u002Fng2015",{"doi":1788},"10.1038\u002Fng2015",{"id":21,"text":1790,"url":21,"identifiers":1791},"Wasserman, 2010, An 8q24 gene desert variant associated with prostate cancer risk confers differential in vivo activity to a MYC enhancer, Genome Res., 20, 1191, 10.1101\u002Fgr.105361.110",{"doi":1792},"10.1101\u002Fgr.105361.110",{"id":21,"text":1794,"url":21,"identifiers":1795},"Oktay, 2016, IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation, Sci. Rep., 6, 27569, 10.1038\u002Fsrep27569",{"doi":1796},"10.1038\u002Fsrep27569",{"id":21,"text":1798,"url":21,"identifiers":1799},"Tomlinson, 2008, A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3, Nat. Genet., 40, 623, 10.1038\u002Fng.111",{"doi":1800},"10.1038\u002Fng.111",{"id":21,"text":1802,"url":21,"identifiers":1803},"Haiman, 2007, A common genetic risk factor for colorectal and prostate cancer, Nat. Genet., 39, 954, 10.1038\u002Fng2098",{"doi":1804},"10.1038\u002Fng2098",{"id":21,"text":1806,"url":21,"identifiers":1807},"Pomerantz, 2009, The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer, Nat. Genet., 41, 882, 10.1038\u002Fng.403",{"doi":1808},"10.1038\u002Fng.403",{"id":21,"text":1810,"url":21,"identifiers":1811},"Tuupanen, 2009, The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced WNT signaling, Nat. Genet., 41, 885, 10.1038\u002Fng.406",{"doi":1812},"10.1038\u002Fng.406",{"id":21,"text":1814,"url":21,"identifiers":1815},"Sur, 2016, The role of enhancers in cancer, Nat. Rev. Cancer, 16, 483, 10.1038\u002Fnrc.2016.62",{"doi":1816},"10.1038\u002Fnrc.2016.62",{"id":21,"text":1818,"url":21,"identifiers":1819},"Shi, 2013, Role of SWI\u002FSNF in acute leukemia maintenance and enhancer-mediated MYC regulation, Genes Dev., 27, 2648, 10.1101\u002Fgad.232710.113",{"doi":1820},"10.1101\u002Fgad.232710.113",{"id":21,"text":1822,"url":21,"identifiers":1823},"Pinz, S., Unser, S., and Rascle, A. (2016). Signal transducer and activator of transcription STAT5 is recruited to c-MYC super-enhancer. BMC Mol. Biol., 17.",{"doi":1824},"10.1186\u002Fs12867-016-0063-y",{"id":21,"text":1826,"url":21,"identifiers":1827},"Radtke, 2009, Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia, Proc. Natl. Acad. Sci. USA, 106, 12944, 10.1073\u002Fpnas.0903142106",{"doi":1828},"10.1073\u002Fpnas.0903142106",{"id":21,"text":1830,"url":21,"identifiers":1831},"Kuhn, 2012, High-resolution genomic profiling of adult and pediatric core-binding factor acute myeloid leukemia reveals new recurrent genomic alterations, Blood, 119, e67, 10.1182\u002Fblood-2011-09-380444",{"doi":1832},"10.1182\u002Fblood-2011-09-380444",{"id":21,"text":1834,"url":21,"identifiers":1835},"Hnisz, 2013, Super-enhancers in the control of cell identity and disease, Cell, 155, 934, 10.1016\u002Fj.cell.2013.09.053",{"doi":1836},"10.1016\u002Fj.cell.2013.09.053",{"id":21,"text":1838,"url":21,"identifiers":1839},"Rennoll, 2015, Regulation of MYC gene expression by aberrant WNT\u002Fβ-catenin signaling in colorectal cancer, World J. Biol. Chem., 6, 290, 10.4331\u002Fwjbc.v6.i4.290",{"doi":1840},"10.4331\u002Fwjbc.v6.i4.290",{"id":21,"text":1842,"url":21,"identifiers":1843},"Yochum, G.S. (2011). Multiple WNT\u002Fβ-catenin responsive enhancers align with the MYC promoter through long-range chromatin loops. PLoS ONE, 6.",{"doi":1844},"10.1371\u002Fjournal.pone.0018966",{"id":21,"text":1846,"url":21,"identifiers":1847},"Herranz, 2014, A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia, Nat. Med., 20, 1130, 10.1038\u002Fnm.3665",{"doi":1848},"10.1038\u002Fnm.3665",{"id":21,"text":1850,"url":21,"identifiers":1851},"Ryan, 2015, Detection of enhancer-associated rearrangements reveals mechanisms of oncogene dysregulation in B-cell lymphoma, Cancer Discov., 5, 1058, 10.1158\u002F2159-8290.CD-15-0370",{"doi":1852},"10.1158\u002F2159-8290.CD-15-0370",{"id":21,"text":1854,"url":21,"identifiers":1855},"Affer, 2014, Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma, Leukemia, 28, 1725, 10.1038\u002Fleu.2014.70",{"doi":1856},"10.1038\u002Fleu.2014.70",{"id":21,"text":1858,"url":21,"identifiers":1859},"Delmore, 2011, Bet bromodomain inhibition as a therapeutic strategy to target c-MYC, Cell, 146, 904, 10.1016\u002Fj.cell.2011.08.017",{"doi":1860},"10.1016\u002Fj.cell.2011.08.017",{"id":21,"text":1862,"url":21,"identifiers":1863},"Gregory, 2003, Phosphorylation by glycogen synthase kinase-3 controls c-MYC proteolysis and subnuclear localization, J. Biol. Chem., 278, 51606, 10.1074\u002Fjbc.M310722200",{"doi":1864},"10.1074\u002Fjbc.M310722200",{"id":21,"text":1866,"url":21,"identifiers":1867},"Yeh, 2004, A signalling pathway controlling c-MYC degradation that impacts oncogenic transformation of human cells, Nat. Cell Biol., 6, 308, 10.1038\u002Fncb1110",{"doi":1868},"10.1038\u002Fncb1110",{"id":21,"text":1870,"url":21,"identifiers":1871},"Popov, 2007, The ubiquitin-specific protease USP28 is required for MYC stability, Nat. Cell Biol., 9, 765, 10.1038\u002Fncb1601",{"doi":1872},"10.1038\u002Fncb1601",{"id":21,"text":1874,"url":21,"identifiers":1875},"Pan, 2015, USP37 directly deubiquitinates and stabilizes c-MYC in lung cancer, Oncogene, 34, 3957, 10.1038\u002Fonc.2014.327",{"doi":1876},"10.1038\u002Fonc.2014.327",{"id":21,"text":1878,"url":21,"identifiers":1879},"Kim, D., Hong, A., Park, H.I., Shin, W.H., Yoo, L., Jeon, S.J., and Chung, K.C. (2017). Deubiquitinating enzyme USP22 positively regulates c-MYC stability and tumorigenic activity in mammalian and breast cancer cells. J. Cell. Physiol.",{"doi":1880},"10.1002\u002Fjcp.25841",{"id":21,"text":1882,"url":21,"identifiers":1883},"Diefenbacher, 2014, The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer, J. Clin. Investig., 124, 3407, 10.1172\u002FJCI73733",{"doi":1884},"10.1172\u002FJCI73733",{"id":21,"text":1886,"url":21,"identifiers":1887},"Akhoondi, 2007, FBXW7\u002FhCDC4 is a general tumor suppressor in human cancer, Cancer Res., 67, 9006, 10.1158\u002F0008-5472.CAN-07-1320",{"doi":1888},"10.1158\u002F0008-5472.CAN-07-1320",{"id":21,"text":1890,"url":21,"identifiers":1891},"Sun, 2015, The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-MYC, Proc. Natl. Acad. Sci. USA, 112, 3734, 10.1073\u002Fpnas.1411713112",{"doi":1892},"10.1073\u002Fpnas.1411713112",{"id":21,"text":1894,"url":21,"identifiers":1895},"Welcker, 2004, A nucleolar isoform of the FBW7 ubiquitin ligase regulates c-MYC and cell size, Curr. Biol., 14, 1852, 10.1016\u002Fj.cub.2004.09.083",{"doi":1896},"10.1016\u002Fj.cub.2004.09.083",{"id":21,"text":1898,"url":21,"identifiers":1899},"Kim, 2003, SKP2 regulates MYC protein stability and activity, Mol. Cell, 11, 1177, 10.1016\u002FS1097-2765(03)00173-4",{"doi":1900},"10.1016\u002FS1097-2765(03)00173-4",{"id":21,"text":1902,"url":21,"identifiers":1903},"Kimura, 2007, MM-1 facilitates degradation of c-MYC by recruiting proteasome and a novel ubiquitin E3 ligase, Int. J. Oncol., 31, 829",{},{"id":21,"text":1905,"url":21,"identifiers":1906},"Johansson, 2003, Implication of the ubiquitin\u002Fproteasome system in MYC-regulated transcription, Cell Cycle, 2, 403",{},{"id":21,"text":1908,"url":21,"identifiers":1909},"Gstaiger, 2001, SKP2 is oncogenic and overexpressed in human cancers, Proc. Natl. Acad. Sci. USA, 98, 5043, 10.1073\u002Fpnas.081474898",{"doi":1910},"10.1073\u002Fpnas.081474898",{"id":21,"text":1912,"url":21,"identifiers":1913},"Cowling, 2014, Burkitt’s lymphoma-associated c-MYC mutations converge on a dramatically altered target gene response and implicate NOL5A\u002FNOP56 in oncogenesis, Oncogene, 33, 3519, 10.1038\u002Fonc.2013.338",{"doi":1914},"10.1038\u002Fonc.2013.338",{"id":21,"text":1916,"url":21,"identifiers":1917},"Bonilla, 2016, Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma, Nat. Genet., 48, 398, 10.1038\u002Fng.3525",{"doi":1918},"10.1038\u002Fng.3525",{"id":21,"text":1920,"url":21,"identifiers":1921},"Bhatia, 1993, Point mutations in the c-MYC transactivation domain are common in burkitt’s lymphoma and mouse plasmacytomas, Nat. Genet., 5, 56, 10.1038\u002Fng0993-56",{"doi":1922},"10.1038\u002Fng0993-56",{"id":21,"text":1924,"url":21,"identifiers":1925},"Love, 2012, The genetic landscape of mutations in burkitt lymphoma, Nat. Genet., 44, 1321, 10.1038\u002Fng.2468",{"doi":1926},"10.1038\u002Fng.2468",{"id":21,"text":1928,"url":21,"identifiers":1929},"Schmitz, 2012, Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics, Nature, 490, 116, 10.1038\u002Fnature11378",{"doi":1930},"10.1038\u002Fnature11378",{"id":21,"text":1932,"url":21,"identifiers":1933},"Richter, 2012, Recurrent mutation of the ID3 gene in burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing, Nat. Genet., 44, 1316, 10.1038\u002Fng.2469",{"doi":1934},"10.1038\u002Fng.2469",{"id":21,"text":1936,"url":21,"identifiers":1937},"Bahram, 2000, c-MYC hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover, Blood, 95, 2104, 10.1182\u002Fblood.V95.6.2104",{"doi":1938},"10.1182\u002Fblood.V95.6.2104",{"id":21,"text":1940,"url":21,"identifiers":1941},"Symonds, 1989, Transformation of murine myelomonocytic cells by MYC: Point mutations in v-MYC contribute synergistically to transforming potential, Oncogene, 4, 285",{},{"id":21,"text":1943,"url":21,"identifiers":1944},"Hemann, 2005, Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants, Nature, 436, 807, 10.1038\u002Fnature03845",{"doi":1945},"10.1038\u002Fnature03845",{"id":21,"text":1947,"url":21,"identifiers":1948},"Chang, 2000, The c-MYC transactivation domain is a direct modulator of apoptotic versus proliferative signals, Mol. Cell. Biol., 20, 4309, 10.1128\u002FMCB.20.12.4309-4319.2000",{"doi":1949},"10.1128\u002FMCB.20.12.4309-4319.2000",{"id":21,"text":1951,"url":21,"identifiers":1952},"Chakraborty, 2015, A common functional consequence of tumor-derived mutations within c-MYC, Oncogene, 34, 2406, 10.1038\u002Fonc.2014.186",{"doi":1953},"10.1038\u002Fonc.2014.186",{"id":21,"text":1955,"url":21,"identifiers":1956},"Richards, 2016, Structural basis of N-MYC binding by Aurora-A and its destabilization by kinase inhibitors, Proc. Natl. Acad. Sci. USA, 113, 13726, 10.1073\u002Fpnas.1610626113",{"doi":1957},"10.1073\u002Fpnas.1610626113",{"id":21,"text":1959,"url":21,"identifiers":1960},"Kandoth, 2013, Mutational landscape and significance across 12 major cancer types, Nature, 502, 333, 10.1038\u002Fnature12634",{"doi":1961},"10.1038\u002Fnature12634",{"id":21,"text":1963,"url":21,"identifiers":1964},"Stokoe, 1997, Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B, Science, 277, 567, 10.1126\u002Fscience.277.5325.567",{"doi":1965},"10.1126\u002Fscience.277.5325.567",{"id":21,"text":1967,"url":21,"identifiers":1968},"Maehama, 1998, The tumor suppressor, PTEN\u002FMMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate, J. Biol. Chem., 273, 13375, 10.1074\u002Fjbc.273.22.13375",{"doi":1969},"10.1074\u002Fjbc.273.22.13375",{"id":21,"text":1971,"url":21,"identifiers":1972},"Myers, 1998, The lipid phosphatase activity of pten is critical for its tumor supressor function, Proc. Natl. Acad. Sci. USA, 95, 13513, 10.1073\u002Fpnas.95.23.13513",{"doi":1973},"10.1073\u002Fpnas.95.23.13513",{"id":21,"text":1975,"url":21,"identifiers":1976},"Osaki, 2004, Pi3k-akt pathway: Its functions and alterations in human cancer, Apoptosis, 9, 667, 10.1023\u002FB:APPT.0000045801.15585.dd",{"doi":1977},"10.1023\u002FB:APPT.0000045801.15585.dd",{"id":21,"text":1979,"url":21,"identifiers":1980},"Cross, 1995, Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B, Nature, 378, 785, 10.1038\u002F378785a0",{"doi":1981},"10.1038\u002F378785a0",{"id":21,"text":1983,"url":21,"identifiers":1984},"Zhao, 2008, Helical domain and kinase domain mutations in p110α of phosphatidylinositol 3-kinase induce gain of function by different mechanisms, Proc. Natl. Acad. Sci. USA, 105, 2652, 10.1073\u002Fpnas.0712169105",{"doi":1985},"10.1073\u002Fpnas.0712169105",{"id":21,"text":1987,"url":21,"identifiers":1988},"Li, 1997, PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer, Science, 275, 1943, 10.1126\u002Fscience.275.5308.1943",{"doi":1989},"10.1126\u002Fscience.275.5308.1943",{"id":21,"text":1991,"url":21,"identifiers":1992},"Stambolic, 1998, Negative regulation of PKB\u002FAkt-dependent cell survival by the tumor suppressor PTEN, Cell, 95, 29, 10.1016\u002FS0092-8674(00)81780-8",{"doi":1993},"10.1016\u002FS0092-8674(00)81780-8",{"id":21,"text":1995,"url":21,"identifiers":1996},"Chardin, 1993, Human SOS1: A guanine nucleotide exchange factor for ras that binds to GRB2, Science, 260, 1338, 10.1126\u002Fscience.8493579",{"doi":1997},"10.1126\u002Fscience.8493579",{"id":21,"text":1999,"url":21,"identifiers":2000},"Roberts, 2007, Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer, Oncogene, 26, 3291, 10.1038\u002Fsj.onc.1210422",{"doi":2001},"10.1038\u002Fsj.onc.1210422",{"id":21,"text":2003,"url":21,"identifiers":2004},"Hayes, 2016, Long-term ERK inhibition in KRAS-mutant pancreatic cancer is associated with MYC degradation and senescence-like growth suppression, Cancer Cell, 29, 75, 10.1016\u002Fj.ccell.2015.11.011",{"doi":2005},"10.1016\u002Fj.ccell.2015.11.011",{"id":21,"text":2007,"url":21,"identifiers":2008},"Suire, 2002, Activation of phosphoinositide 3-kinase gamma by RAS, Curr. Biol., 12, 1068, 10.1016\u002FS0960-9822(02)00933-8",{"doi":2009},"10.1016\u002FS0960-9822(02)00933-8",{"id":21,"text":2011,"url":21,"identifiers":2012},"Warne, 1994, Phosphatidylinositol-3-OH kinase as a direct target of RAS, Nature, 370, 527, 10.1038\u002F370527a0",{"doi":2013},"10.1038\u002F370527a0",{"id":21,"text":2015,"url":21,"identifiers":2016},"Kodaki, 1994, The activation of phosphatidylinositol 3-kinase by RAS, Curr. Biol., 4, 798, 10.1016\u002FS0960-9822(00)00177-9",{"doi":2017},"10.1016\u002FS0960-9822(00)00177-9",{"id":21,"text":2019,"url":21,"identifiers":2020},"Rottmann, 2006, The mad side of the MAX network: Antagonizing the function of MYC and more, Curr. Top. Microbiol. Immunol., 302, 63",{},{"id":21,"text":2022,"url":21,"identifiers":2023},"Ayer, 1993, Mad: A heterodimeric partner for MAX that antagonizes MYC transcriptional activity, Cell, 72, 211, 10.1016\u002F0092-8674(93)90661-9",{"doi":2024},"10.1016\u002F0092-8674(93)90661-9",{"id":21,"text":2026,"url":21,"identifiers":2027},"Zhu, 2008, Activation of PI3K\u002FAKT and MAPK pathways regulates MYC-mediated transcription by phosphorylating and promoting the degradation of MAD1, Proc. Natl. Acad. Sci. USA, 105, 6584, 10.1073\u002Fpnas.0802785105",{"doi":2028},"10.1073\u002Fpnas.0802785105",{"id":21,"text":2030,"url":21,"identifiers":2031},"Prior, 2012, A comprehensive survey of RAS mutations in cancer, Cancer Res., 72, 2457, 10.1158\u002F0008-5472.CAN-11-2612",{"doi":2032},"10.1158\u002F0008-5472.CAN-11-2612",{"id":21,"text":2034,"url":21,"identifiers":2035},"Gibbs, 1988, Purification of RAS GTPase activating protein from bovine brain, Proc. Natl. Acad. Sci. USA, 85, 5026, 10.1073\u002Fpnas.85.14.5026",{"doi":2036},"10.1073\u002Fpnas.85.14.5026",{"id":21,"text":2038,"url":21,"identifiers":2039},"Vogel, 1988, Cloning of bovine GAP and its interaction with oncogenic RAS p21, Nature, 335, 90, 10.1038\u002F335090a0",{"doi":2040},"10.1038\u002F335090a0",{"id":21,"text":2042,"url":21,"identifiers":2043},"Franken, 1993, Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-RAS, Biochemistry, 32, 8411, 10.1021\u002Fbi00084a005",{"doi":2044},"10.1021\u002Fbi00084a005",{"id":21,"text":2046,"url":21,"identifiers":2047},"Gremer, 2008, Fluoride complexes of oncogenic RAS mutants to study the RAS-RASGAP interaction, Biol. Chem., 389, 1163, 10.1515\u002FBC.2008.132",{"doi":2048},"10.1515\u002FBC.2008.132",{"id":21,"text":2050,"url":21,"identifiers":2051},"Davies, 2002, Mutations of the braf gene in human cancer, Nature, 417, 949, 10.1038\u002Fnature00766",{"doi":2052},"10.1038\u002Fnature00766",{"id":21,"text":2054,"url":21,"identifiers":2055},"Rizzo, 2016, BRAF and MEK inhibitors in pediatric glioma: New therapeutic strategies, new toxicities, Expert Opin. Drug Metab. Toxicol., 12, 1397, 10.1080\u002F17425255.2016.1214710",{"doi":2056},"10.1080\u002F17425255.2016.1214710",{"id":21,"text":2058,"url":21,"identifiers":2059},"Bartram, 1983, Translocation of c-ab1 oncogene correlates with the presence of a philadelphia chromosome in chronic myelocytic leukaemia, Nature, 306, 277, 10.1038\u002F306277a0",{"doi":2060},"10.1038\u002F306277a0",{"id":21,"text":2062,"url":21,"identifiers":2063},"Sawyers, 1992, Dominant negative MYC blocks transformation by ABL oncogenes, Cell, 70, 901, 10.1016\u002F0092-8674(92)90241-4",{"doi":2064},"10.1016\u002F0092-8674(92)90241-4",{"id":21,"text":2066,"url":21,"identifiers":2067},"Ratajczak, 1994, The role of c-MYC protooncogene in chronic myelogenous leukemia, Folia Histochem. Cytobiol., 32, 231",{},{"id":21,"text":2069,"url":21,"identifiers":2070},"Miyamoto, 2001, The JAK2 inhibitor AG490 predominantly abrogates the growth of human B-precursor leukemic cells with 11q23 translocation or philadelphia chromosome, Leukemia, 15, 1758, 10.1038\u002Fsj.leu.2402260",{"doi":2071},"10.1038\u002Fsj.leu.2402260",{"id":21,"text":2073,"url":21,"identifiers":2074},"Ariyoshi, 2000, Constitutive activation of STAT5 by a point mutation in the SH2 domain, J. Biol. Chem., 275, 24407, 10.1074\u002Fjbc.M909771199",{"doi":2075},"10.1074\u002Fjbc.M909771199",{"id":21,"text":2077,"url":21,"identifiers":2078},"Oliver, 2012, BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia, Nat. Chem. Biol., 8, 285, 10.1038\u002Fnchembio.775",{"doi":2079},"10.1038\u002Fnchembio.775",{"id":21,"text":2081,"url":21,"identifiers":2082},"Lord, 2000, The IL-2 receptor promotes lymphocyte proliferation and induction of the c-MYC, Bcl-2, and Bcl-x genes through the trans-activation domain of STAT5, J. Immunol., 164, 2533, 10.4049\u002Fjimmunol.164.5.2533",{"doi":2083},"10.4049\u002Fjimmunol.164.5.2533",{"id":21,"text":2085,"url":21,"identifiers":2086},"Nosaka, 1999, STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells, EMBO J., 18, 4754, 10.1093\u002Femboj\u002F18.17.4754",{"doi":2087},"10.1093\u002Femboj\u002F18.17.4754",{"id":21,"text":2089,"url":21,"identifiers":2090},"Beth, 2008, In vivo identification of novel STAT5 target genes, Nucleic Acids Res., 36, 3802, 10.1093\u002Fnar\u002Fgkn271",{"doi":2091},"10.1093\u002Fnar\u002Fgkn271",{"id":21,"text":2093,"url":21,"identifiers":2094},"Pinz, 2015, Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (bet) protein function, Nucleic Acids Res., 43, 3524, 10.1093\u002Fnar\u002Fgkv188",{"doi":2095},"10.1093\u002Fnar\u002Fgkv188",{"id":21,"text":2097,"url":21,"identifiers":2098},"Kralovics, 2008, Genetic complexity of myeloproliferative neoplasms, Leukemia, 22, 1841, 10.1038\u002Fleu.2008.233",{"doi":2099},"10.1038\u002Fleu.2008.233",{"id":21,"text":2101,"url":21,"identifiers":2102},"James, 2005, A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera, Nature, 434, 1144, 10.1038\u002Fnature03546",{"doi":2103},"10.1038\u002Fnature03546",{"id":21,"text":2105,"url":21,"identifiers":2106},"Hassan, 2015, Coexistence of JAK2 and BCR-ABL mutation in patient with myeloproliferative neoplasm, Niger. Med. J., 56, 74, 10.4103\u002F0300-1652.149177",{"doi":2107},"10.4103\u002F0300-1652.149177",{"id":21,"text":2109,"url":21,"identifiers":2110},"Pahore, 2011, JAK2V617F mutation in chronic myeloid leukemia predicts early disease progression, J. Coll. Phys. Surg. Pak., 21, 472",{},{"id":21,"text":2112,"url":21,"identifiers":2113},"Dubik, 1987, Stimulation of c-MYC oncogene expression associated with estrogen-induced proliferation of human breast cancer cells, Cancer Res., 47, 6517",{},{"id":21,"text":2115,"url":21,"identifiers":2116},"Dubik, 1992, Mechanism of estrogen activation of c-MYC oncogene expression, Oncogene, 7, 1587",{},{"id":21,"text":2118,"url":21,"identifiers":2119},"Carroll, 2006, Genome-wide analysis of estrogen receptor binding sites, Nat. Genet., 38, 1289, 10.1038\u002Fng1901",{"doi":2120},"10.1038\u002Fng1901",{"id":21,"text":2122,"url":21,"identifiers":2123},"Butt, 2008, Cell cycle machinery: Links with genesis and treatment of breast cancer, Adv. Exp. Med. Biol., 630, 189, 10.1007\u002F978-0-387-78818-0_12",{"doi":2124},"10.1007\u002F978-0-387-78818-0_12",{"id":21,"text":2126,"url":21,"identifiers":2127},"Alles, M.C., Margaret, G.-G., David, J.N., Yixin, W., John, A.F., Robert, L.S., Elizabeth, A.M., and Christopher, J.O. (2009). Meta-analysis and gene set enrichment relative to er status reveal elevated activity of MYC and E2F in the “basal” breast cancer subgroup. PLoS ONE, 4.",{"doi":2128},"10.1371\u002Fjournal.pone.0004710",{"id":21,"text":2130,"url":21,"identifiers":2131},"Musgrove, E.A., Sergio, C.M., Loi, S., Inman, C.K., Anderson, L.R., Alles, M.C., Pinese, M., Caldon, C.E., Schütte, J., and Gardiner-Garden, M. (2008). Identification of functional networks of estrogen- and c-MYC-responsive genes and their relationship to response to tamoxifen therapy in breast cancer. PLoS ONE, 3.",{"doi":2132},"10.1371\u002Fjournal.pone.0002987",{"id":21,"text":2134,"url":21,"identifiers":2135},"Chandriani, S., Frengen, E., Cowling, V.H., Pendergrass, S.A., Perou, C.M., Whitfield, M.L., and Cole, M.D. (2009). A core MYC gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response. PLoS ONE, 4.",{"doi":2136},"10.1371\u002Fjournal.pone.0006693",{"id":21,"text":2138,"url":21,"identifiers":2139},"Tanaka, 1999, Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast, Cancer Res., 59, 2041",{},{"id":21,"text":2141,"url":21,"identifiers":2142},"Zheng, 2016, Nuclear aurka acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype, Nat. Commun., 7, 10180, 10.1038\u002Fncomms10180",{"doi":2143},"10.1038\u002Fncomms10180",{"id":21,"text":2145,"url":21,"identifiers":2146},"Zhou, 1998, Tumour amplified kinase STK15\u002FBTAK induces centrosome amplification, aneuploidy and transformation, Nat. Genet., 20, 189, 10.1038\u002F2496",{"doi":2147},"10.1038\u002F2496",{"id":21,"text":2149,"url":21,"identifiers":2150},"Frederick, 2004, Transforming growth factor β-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element, Mol. Cell. Biol., 24, 2546, 10.1128\u002FMCB.24.6.2546-2559.2004",{"doi":2151},"10.1128\u002FMCB.24.6.2546-2559.2004",{"id":21,"text":2153,"url":21,"identifiers":2154},"Yagi, 2001, C-MYC is a downstream target of the SMAD pathway, J. Biol. Chem., 277, 854, 10.1074\u002Fjbc.M104170200",{"doi":2155},"10.1074\u002Fjbc.M104170200",{"id":21,"text":2157,"url":21,"identifiers":2158},"Jeruss, 2003, Down-regulation of activin, activin receptors, and SMADS in high-grade breast cancer, Cancer Res., 63, 3783",{},{"id":21,"text":2160,"url":21,"identifiers":2161},"Sekimoto, 2007, Reversible SMAD-dependent signaling between tumor suppression and oncogenesis, Cancer Res., 67, 5090, 10.1158\u002F0008-5472.CAN-06-4629",{"doi":2162},"10.1158\u002F0008-5472.CAN-06-4629",{"id":21,"text":2164,"url":21,"identifiers":2165},"Chen, 2001, Defective repression of c-MYC in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program, Proc. Natl. Acad. Sci. USA, 98, 992, 10.1073\u002Fpnas.98.3.992",{"doi":2166},"10.1073\u002Fpnas.98.3.992",{"id":21,"text":2168,"url":21,"identifiers":2169},"Shi, 2017, Research of the relationship between β-catenin and c-myc-mediated Wnt pathway and laterally spreading tumors occurrence, Eur. Rev. Med. Pharmacol. Sci., 21, 252",{},{"id":21,"text":2171,"url":21,"identifiers":2172},"Zhan, 2017, WNT signaling in cancer, Oncogene, 36, 1461, 10.1038\u002Fonc.2016.304",{"doi":2173},"10.1038\u002Fonc.2016.304",{"id":21,"text":2175,"url":21,"identifiers":2176},"Myant, 2011, WNT\u002FMYC interactions in intestinal cancer: Partners in crime, Exp. Cell Res., 317, 2725, 10.1016\u002Fj.yexcr.2011.08.001",{"doi":2177},"10.1016\u002Fj.yexcr.2011.08.001",{"id":21,"text":2179,"url":21,"identifiers":2180},"Najdi, 2011, WNT signaling and colon carcinogenesis: Beyond APC, J. Carcinog., 10, 5, 10.4103\u002F1477-3163.78111",{"doi":2181},"10.4103\u002F1477-3163.78111",{"id":21,"text":2183,"url":21,"identifiers":2184},"Morin, 1997, Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC, Science, 275, 1787, 10.1126\u002Fscience.275.5307.1787",{"doi":2185},"10.1126\u002Fscience.275.5307.1787",{"id":21,"text":2187,"url":21,"identifiers":2188},"Liu, 2000, Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin\u002FTCF signalling, Nat. Genet., 26, 146, 10.1038\u002F79859",{"doi":2189},"10.1038\u002F79859",{"id":21,"text":2191,"url":21,"identifiers":2192},"Mazzoni, 2014, AXIN1 and AXIN2 variants in gastrointestinal cancers, Cancer Lett., 355, 1, 10.1016\u002Fj.canlet.2014.09.018",{"doi":2193},"10.1016\u002Fj.canlet.2014.09.018",{"id":21,"text":2195,"url":21,"identifiers":2196},"Schlaeger, 2008, Etiology-dependent molecular mechanisms in human hepatocarcinogenesis, Hepatology, 47, 511, 10.1002\u002Fhep.22033",{"doi":2197},"10.1002\u002Fhep.22033",{"id":21,"text":2199,"url":21,"identifiers":2200},"Nesbit, 1999, MYC oncogenes and human neoplastic disease, Oncogene, 18, 3004, 10.1038\u002Fsj.onc.1202746",{"doi":2201},"10.1038\u002Fsj.onc.1202746",{"id":21,"text":2203,"url":21,"identifiers":2204},"Dolezal, J.M., Wang, H., Kulkarni, S., Jackson, L., Lu, J., Ranganathan, S., Goetzman, E.S., Bharathi, S., Beezhold, K., and Byersdorfer, C.A. (2017). Sequential adaptive changes in a c-MYC-driven model of hepatocellular carcinoma. J. Biol. Chem.",{"doi":2205},"10.1074\u002Fjbc.M117.782052",{"id":21,"text":2207,"url":21,"identifiers":2208},"Aretz, 2006, Should children at risk for familial adenomatous polyposis be screened for hepatoblastoma and children with apparently sporadic hepatoblastoma be screened for APC germline mutations?, Pediatr. Blood Cancer, 47, 811, 10.1002\u002Fpbc.20698",{"doi":2209},"10.1002\u002Fpbc.20698",{"id":21,"text":2211,"url":21,"identifiers":2212},"Cairo, 2008, Hepatic stem-like phenotype and interplay of WNT\u002Fβ-catenin and MYC signaling in aggressive childhood liver cancer, Cancer Cell, 14, 471, 10.1016\u002Fj.ccr.2008.11.002",{"doi":2213},"10.1016\u002Fj.ccr.2008.11.002",{"id":21,"text":2215,"url":21,"identifiers":2216},"Wang, 2016, Coordinated activities of multiple MYC-dependent and MYC-independent biosynthetic pathways in hepatoblastoma, J. Biol. Chem., 291, 26241, 10.1074\u002Fjbc.M116.754218",{"doi":2217},"10.1074\u002Fjbc.M116.754218",{"id":21,"text":2219,"url":21,"identifiers":2220},"Kan, 2013, Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma, Genome Res., 23, 1422, 10.1101\u002Fgr.154492.113",{"doi":2221},"10.1101\u002Fgr.154492.113",{"id":21,"text":2223,"url":21,"identifiers":2224},"Ding, X., Yang, Y., Han, B., Du, C., Xu, N., Huang, H., Cai, T., Zhang, A., Han, Z.G., and Zhou, W. (2014). Transcriptomic characterization of hepatocellular carcinoma with CTNNB1 mutation. PLoS ONE, 9.",{"doi":2225},"10.1371\u002Fjournal.pone.0095307",{"id":21,"text":2227,"url":21,"identifiers":2228},"Ferrando, 2017, The NOTCH1-MYC highway towards T-cell acute lymphoblastic leukemia, Blood, 129, 1124, 10.1182\u002Fblood-2016-09-692582",{"doi":2229},"10.1182\u002Fblood-2016-09-692582",{"id":21,"text":2231,"url":21,"identifiers":2232},"Kopan, 2012, Notch signaling, Cold Spring Harb. Perspect. Biol., 4, a011213, 10.1101\u002Fcshperspect.a011213",{"doi":2233},"10.1101\u002Fcshperspect.a011213",{"id":21,"text":2235,"url":21,"identifiers":2236},"Ellisen, 1991, TAN-1, the human homolog of the drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms, Cell, 66, 649, 10.1016\u002F0092-8674(91)90111-B",{"doi":2237},"10.1016\u002F0092-8674(91)90111-B",{"id":21,"text":2239,"url":21,"identifiers":2240},"Weng, 2004, Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia, Science, 306, 269, 10.1126\u002Fscience.1102160",{"doi":2241},"10.1126\u002Fscience.1102160",{"id":21,"text":2243,"url":21,"identifiers":2244},"Grim, 2007, FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors, J. Exp. Med., 204, 1813, 10.1084\u002Fjem.20070876",{"doi":2245},"10.1084\u002Fjem.20070876",{"id":21,"text":2247,"url":21,"identifiers":2248},"Thompson, 2007, The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia, J. Exp. Med., 204, 1825, 10.1084\u002Fjem.20070872",{"doi":2249},"10.1084\u002Fjem.20070872",{"id":21,"text":2251,"url":21,"identifiers":2252},"King, 2013, The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability, Cell, 153, 1552, 10.1016\u002Fj.cell.2013.05.041",{"doi":2253},"10.1016\u002Fj.cell.2013.05.041",{"id":21,"text":2255,"url":21,"identifiers":2256},"Mertins, 2016, Proteogenomics connects somatic mutations to signalling in breast cancer, Nature, 534, 55, 10.1038\u002Fnature18003",{"doi":2257},"10.1038\u002Fnature18003",{"id":21,"text":2259,"url":21,"identifiers":2260},"Zhang, 2014, Proteogenomic characterization of human colon and rectal cancer, Nature, 513, 382, 10.1038\u002Fnature13438",{"doi":2261},"10.1038\u002Fnature13438",{"id":21,"text":2263,"url":21,"identifiers":2264},"Zhang, 2016, Integrated proteogenomic characterization of human high-grade serous ovarian cancer, Cell, 166, 755, 10.1016\u002Fj.cell.2016.05.069",{"doi":2265},"10.1016\u002Fj.cell.2016.05.069",{"id":21,"text":2267,"url":21,"identifiers":2268},"Wasylishen, 2013, MYC phosphorylation at novel regulatory regions suppresses transforming activity, Cancer Res., 73, 6504, 10.1158\u002F0008-5472.CAN-12-4063",{"doi":2269},"10.1158\u002F0008-5472.CAN-12-4063",{"id":21,"text":2271,"url":21,"identifiers":2272},"Huang, 2004, Negative control of the MYC protein by the stress-responsive kinase PAK2, Mol. Cell. Biol., 24, 1582, 10.1128\u002FMCB.24.4.1582-1594.2004",{"doi":2273},"10.1128\u002FMCB.24.4.1582-1594.2004",{"id":21,"text":2275,"url":21,"identifiers":2276},"Pulverer, 1994, Site-specific modulation of c-MYC cotransformation by residues phosphorylated in vivo, Oncogene, 9, 59",{},{"id":21,"text":2278,"url":21,"identifiers":2279},"Luscher, 1989, MYC oncoproteins are phosphorylated by casein kinase II, EMBO J, 8, 1111, 10.1002\u002Fj.1460-2075.1989.tb03481.x",{"doi":2280},"10.1002\u002Fj.1460-2075.1989.tb03481.x",{"id":21,"text":2282,"url":21,"identifiers":2283},"Kalkat, M., Chan, P.K., Wasylishen, A.R., Srikumar, T., Kim, S.S., Ponzielli, R., Bazett-Jones, D.P., Raught, B., and Penn, L.Z. (2014). Identification of c-MYC sumoylation by mass spectrometry. PLoS ONE, 9.",{"doi":2284},"10.1371\u002Fjournal.pone.0115337",{"id":21,"text":2286,"url":21,"identifiers":2287},"Cuijpers, 2015, c-MYC is targeted to the proteasome for degradation in a sumoylation-dependent manner, regulated by PIAS1, SENP7 and RNF4, Cell Cycle, 14, 1859, 10.1080\u002F15384101.2015.1040965",{"doi":2288},"10.1080\u002F15384101.2015.1040965",{"id":21,"text":2290,"url":21,"identifiers":2291},"Sabo, A., Doni, M., and Amati, B. (2014). Sumoylation of MYC-family proteins. PLoS ONE, 9.",{"doi":2292},"10.1371\u002Fjournal.pone.0091072",{"id":21,"text":2294,"url":21,"identifiers":2295},"Zhang, 2005, Six lysine residues on c-MYC are direct substrates for acetylation by p300, Biochem. Biophys. Res. Commun., 336, 274, 10.1016\u002Fj.bbrc.2005.08.075",{"doi":2296},"10.1016\u002Fj.bbrc.2005.08.075",{"id":21,"text":2298,"url":21,"identifiers":2299},"Faiola, 2005, Dual regulation of c-MYC by p300 via acetylation-dependent control of MYC protein turnover and coactivation of MYC-induced transcription, Mol. Cell. Biol., 25, 10220, 10.1128\u002FMCB.25.23.10220-10234.2005",{"doi":2300},"10.1128\u002FMCB.25.23.10220-10234.2005",{"id":21,"text":2302,"url":21,"identifiers":2303},"(2017, February 27). Phosphositeplus: Myc (human). Available online: http:\u002F\u002Fwww.phosphosite.org\u002FproteinAction.action?id=947&showAllSites=true.",{},{"id":21,"text":2305,"url":21,"identifiers":2306},"Fletcher, 2015, Small-molecule inhibitors of the MYC oncoprotein, Biochim. Biophys. Acta, 1849, 525, 10.1016\u002Fj.bbagrm.2014.03.005",{"doi":2307},"10.1016\u002Fj.bbagrm.2014.03.005",{"id":21,"text":2309,"url":21,"identifiers":2310},"Soucek, 2002, Omomyc, a potential MYC dominant negative, enhances MYC-induced apoptosis, Cancer Res., 62, 3507",{},{"id":21,"text":2312,"url":21,"identifiers":2313},"Soucek, 2008, Modelling MYC inhibition as a cancer therapy, Nature, 455, 679, 10.1038\u002Fnature07260",{"doi":2314},"10.1038\u002Fnature07260",{"id":21,"text":2316,"url":21,"identifiers":2317},"Li, 2014, Inactivation of MYC reverses tumorigenesis, J. Intern. Med., 276, 52, 10.1111\u002Fjoim.12237",{"doi":2318},"10.1111\u002Fjoim.12237",{"id":2320,"createTime":2321,"updateTime":2321,"relativeEntities":2322,"slug":2323,"properties":2324,"entityType":964,"verifyStatus":121,"verifyTime":2321,"verifyNote":1071,"languages":2339,"translateLanguages":21,"viewCount":22,"primaryUrl":2340,"fullTextUrl":21,"authors":2341,"publicationType":991,"publisherRelationship":2412,"citationCount":2464,"citationInfo":2465,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":2467,"openAccess":21,"references":2468,"isForceReanalyzing":1050},"9fd19bc2-33a3-409d-a412-445f7a0885bc","2024-10-09T20:56:58.798+00:00",[],"CpG-and-Non-CpG-Methylation-in-Epigenetic-Gene-Regulation-and-Brain-Function",{"mag":2325,"pmc":2327,"openalex":2329,"abstract":2331,"title":2333,"pm":2335,"doi":2337},{"VOID":2326},"2618782736",{"VOID":2328},"5485512",{"VOID":2330},"W2618782736",{"EN":2332},"\u003Cjats:p>DNA methylation is a major epigenetic mark with important roles in genetic regulation. Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non-CpG sites (CpA, CpT, and CpC). The general functions of CpG and non-CpG methylation include gene silencing or activation depending on the methylated regions. CpG and non-CpG methylation are found throughout the whole genome, including repetitive sequences, enhancers, promoters, and gene bodies. Interestingly, however, non-CpG methylation is restricted to specific cell types, such as pluripotent stem cells, oocytes, neurons, and glial cells. Thus, accumulation of methylation at non-CpG sites and CpG sites in neurons seems to be involved in development and disease etiology. Here, we provide an overview of CpG and non-CpG methylation and their roles in neurological diseases.\u003C\u002Fjats:p>",{"EN":2334},"CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function",{"VOID":2336},"28545252",{"VOID":2338},"10.3390\u002Fgenes8060148",[125],"https:\u002F\u002Fwww.mdpi.com\u002F2073-4425\u002F8\u002F6\u002F148",[2342,2361,2378,2395],{"id":2343,"sortIndex":22,"researcher":21,"roles":2344,"affiliations":2345,"properties":2354,"displayName":2358,"givenName":21,"familyName":21},"7a27ab96-f604-47a8-9f99-c449664534b2",[],[2346],{"id":2347,"sortIndex":22,"affiliation":2348,"properties":21},"7afa9353-87e5-4027-865f-670bdef8b1ba",{"id":2347,"createTime":21,"updateTime":21,"relativeEntities":2349,"slug":21,"properties":2350,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":2353,"statistic":21},[],{"title":2351},{"EN":2352},"Department of Stem Cell and Regenerative Biotechnology, KU Institute of Science and Technology, Konkuk University, Seoul 143-701, Korea.",[],{"orcid":2355,"title":2357,"openalex":2359},{"VOID":2356},"https:\u002F\u002Forcid.org\u002F0000-0002-5267-4360",{"EN":2358},"Hyun Gyung Jang",{"VOID":2360},"A5040083297",{"id":2362,"sortIndex":93,"researcher":21,"roles":2363,"affiliations":2364,"properties":2371,"displayName":2375,"givenName":21,"familyName":21},"239b09ff-5421-42d0-8d51-118f885d67f9",[],[2365],{"id":2347,"sortIndex":22,"affiliation":2366,"properties":21},{"id":2347,"createTime":21,"updateTime":21,"relativeEntities":2367,"slug":21,"properties":2368,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":2370,"statistic":21},[],{"title":2369},{"EN":2352},[],{"orcid":2372,"title":2374,"openalex":2376},{"VOID":2373},"https:\u002F\u002Forcid.org\u002F0000-0001-5588-6919",{"EN":2375},"Woo Yong 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V.E., Martienssen, R.A., and Riggs, A.D. (1996). Epigenetic Mechanisms of Gene Regulation, Cold Spring Harbor Laboratory Press.",{},{"id":21,"text":2473,"url":21,"identifiers":2474},"Portela, 2010, Epigenetic modifications and human disease, Nat. Biotechnol., 28, 1057, 10.1038\u002Fnbt.1685",{"doi":2475},"10.1038\u002Fnbt.1685",{"id":21,"text":2477,"url":21,"identifiers":2478},"Riggs, 1975, X inactivation, differentiation, and DNA methylation, Cytogenet. Genome Res., 14, 9, 10.1159\u002F000130315",{"doi":2479},"10.1159\u002F000130315",{"id":21,"text":2481,"url":21,"identifiers":2482},"Holliday, 1975, DNA modification mechanisms and gene activity during development, Science, 187, 226, 10.1126\u002Fscience.187.4173.226",{"doi":2483},"10.1126\u002Fscience.187.4173.226",{"id":21,"text":2485,"url":21,"identifiers":2486},"Christman, 2002, 5-azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: Mechanistic studies and their implications for cancer therapy, Oncogene, 21, 5483, 10.1038\u002Fsj.onc.1205699",{"doi":2487},"10.1038\u002Fsj.onc.1205699",{"id":21,"text":2489,"url":21,"identifiers":2490},"Lindroth, 2001, Requirement of chromomethylase3 for maintenance of cpxpg methylation, Science, 292, 2077, 10.1126\u002Fscience.1059745",{"doi":2491},"10.1126\u002Fscience.1059745",{"id":21,"text":2493,"url":21,"identifiers":2494},"Laurent, 2010, Dynamic changes in the human methylome during differentiation, Genome Res., 20, 320, 10.1101\u002Fgr.101907.109",{"doi":2495},"10.1101\u002Fgr.101907.109",{"id":21,"text":2497,"url":21,"identifiers":2498},"Lister, 2009, Human DNA methylomes at base resolution show widespread epigenomic differences, Nature, 462, 315, 10.1038\u002Fnature08514",{"doi":2499},"10.1038\u002Fnature08514",{"id":21,"text":2501,"url":21,"identifiers":2502},"Lister, 2013, Global epigenomic reconfiguration during mammalian brain development, Science, 341, 1237905, 10.1126\u002Fscience.1237905",{"doi":2503},"10.1126\u002Fscience.1237905",{"id":21,"text":2505,"url":21,"identifiers":2506},"Gowher, 2001, Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: The enzyme modifies DNA in a non-processive manner and also methylates non-CpG [correction of non-CpA] sites, J. Mol. Biol., 309, 1201, 10.1006\u002Fjmbi.2001.4710",{"doi":2507},"10.1006\u002Fjmbi.2001.4710",{"id":21,"text":2509,"url":21,"identifiers":2510},"Ramsahoye, 2000, Non-cpg methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a, Proc. Natl. Acad. Sci. USA, 97, 5237, 10.1073\u002Fpnas.97.10.5237",{"doi":2511},"10.1073\u002Fpnas.97.10.5237",{"id":21,"text":2513,"url":21,"identifiers":2514},"Schofield, 2003, DNA mismatch repair: Molecular mechanisms and biological function, Ann. Rev. Microbiol., 57, 579, 10.1146\u002Fannurev.micro.57.030502.090847",{"doi":2515},"10.1146\u002Fannurev.micro.57.030502.090847",{"id":21,"text":2517,"url":21,"identifiers":2518},"Ito, 2011, Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine, Science, 333, 1300, 10.1126\u002Fscience.1210597",{"doi":2519},"10.1126\u002Fscience.1210597",{"id":21,"text":2521,"url":21,"identifiers":2522},"He, 2011, Tet-mediated formation of 5-carboxylcytosine and its excision by tdg in mammalian DNA, Science, 333, 1303, 10.1126\u002Fscience.1210944",{"doi":2523},"10.1126\u002Fscience.1210944",{"id":21,"text":2525,"url":21,"identifiers":2526},"Mellen, 2012, MeCP2 binds to 5hmc enriched within active genes and accessible chromatin in the nervous system, Cell, 151, 1417, 10.1016\u002Fj.cell.2012.11.022",{"doi":2527},"10.1016\u002Fj.cell.2012.11.022",{"id":21,"text":2529,"url":21,"identifiers":2530},"Berger, 2009, An operational definition of epigenetics, Genes Dev., 23, 781, 10.1101\u002Fgad.1787609",{"doi":2531},"10.1101\u002Fgad.1787609",{"id":21,"text":2533,"url":21,"identifiers":2534},"Law, 2010, Establishing, maintaining and modifying DNA methylation patterns in plants and animals, Nat. Rev. Genet., 11, 204, 10.1038\u002Fnrg2719",{"doi":2535},"10.1038\u002Fnrg2719",{"id":21,"text":2537,"url":21,"identifiers":2538},"Jaenisch, 2003, Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals, Nat. Genet., 33, 245, 10.1038\u002Fng1089",{"doi":2539},"10.1038\u002Fng1089",{"id":21,"text":2541,"url":21,"identifiers":2542},"Smith, 2013, DNA methylation: Roles in mammalian development, Nat. Rev. Genet., 14, 204, 10.1038\u002Fnrg3354",{"doi":2543},"10.1038\u002Fnrg3354",{"id":21,"text":2545,"url":21,"identifiers":2546},"Illingworth, R., Kerr, A., Desousa, D., Jorgensen, H., Ellis, P., Stalker, J., Jackson, D., Clee, C., Plumb, R., and Rogers, J. (2008). A novel CpG island set identifies tissue-specific methylation at developmental gene loci. PLoS Biol., 6.",{"doi":2547},"10.1371\u002Fjournal.pbio.0060022",{"id":21,"text":2549,"url":21,"identifiers":2550},"Felsenfeld, 2014, A brief history of epigenetics, Cold Spring Harb. Perspect. Biol., 6, a018200, 10.1101\u002Fcshperspect.a018200",{"doi":2551},"10.1101\u002Fcshperspect.a018200",{"id":21,"text":2553,"url":21,"identifiers":2554},"Yang, 2014, Gene body methylation can alter gene expression and is a therapeutic target in cancer, Cancer Cell, 26, 577, 10.1016\u002Fj.ccr.2014.07.028",{"doi":2555},"10.1016\u002Fj.ccr.2014.07.028",{"id":21,"text":2557,"url":21,"identifiers":2558},"Jones, 2012, Functions of DNA methylation: Islands, start sites, gene bodies and beyond, Nat. Rev. Genet., 13, 484, 10.1038\u002Fnrg3230",{"doi":2559},"10.1038\u002Fnrg3230",{"id":21,"text":2561,"url":21,"identifiers":2562},"Chodavarapu, 2010, Relationship between nucleosome positioning and DNA methylation, Nature, 466, 388, 10.1038\u002Fnature09147",{"doi":2563},"10.1038\u002Fnature09147",{"id":21,"text":2565,"url":21,"identifiers":2566},"Shukla, 2011, Ctcf-promoted rna polymerase ii pausing links DNA methylation to splicing, Nature, 479, 74, 10.1038\u002Fnature10442",{"doi":2567},"10.1038\u002Fnature10442",{"id":21,"text":2569,"url":21,"identifiers":2570},"Irizarry, 2009, The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores, Nat. Genet., 41, 178, 10.1038\u002Fng.298",{"doi":2571},"10.1038\u002Fng.298",{"id":21,"text":2573,"url":21,"identifiers":2574},"Alisch, 2012, Age-associated DNA methylation in pediatric populations, Genome Res., 22, 623, 10.1101\u002Fgr.125187.111",{"doi":2575},"10.1101\u002Fgr.125187.111",{"id":21,"text":2577,"url":21,"identifiers":2578},"Pirazzini, 2012, Space\u002Fpopulation and time\u002Fage in DNA methylation variability in humans: A study on igf2\u002Fh19 locus in different italian populations and in mono- and di-zygotic twins of different age, Aging, 4, 509, 10.18632\u002Faging.100476",{"doi":2579},"10.18632\u002Faging.100476",{"id":21,"text":2581,"url":21,"identifiers":2582},"Heyn, 2012, Distinct DNA methylomes of newborns and centenarians, Proc. Natl. Acad. Sci. USA, 109, 10522, 10.1073\u002Fpnas.1120658109",{"doi":2583},"10.1073\u002Fpnas.1120658109",{"id":21,"text":2585,"url":21,"identifiers":2586},"Shimoda, 2014, Decrease in cytosine methylation at CpG island shores and increase in DNA fragmentation during zebrafish aging, Age, 36, 103, 10.1007\u002Fs11357-013-9548-5",{"doi":2587},"10.1007\u002Fs11357-013-9548-5",{"id":21,"text":2589,"url":21,"identifiers":2590},"Yen, 1992, Isolation and characterization of the cdna encoding human DNA methyltransferase, Nucleic Acids Res., 20, 2287, 10.1093\u002Fnar\u002F20.9.2287",{"doi":2591},"10.1093\u002Fnar\u002F20.9.2287",{"id":21,"text":2593,"url":21,"identifiers":2594},"Feng, 2009, The role of DNA methylation in the central nervous system and neuropsychiatric disorders, Int. Rev. Neurobiol., 89, 67, 10.1016\u002FS0074-7742(09)89004-1",{"doi":2595},"10.1016\u002FS0074-7742(09)89004-1",{"id":21,"text":2597,"url":21,"identifiers":2598},"Chen, 2003, Derepression of Bdnf transcription involves calcium-dependent phosphorylation of MeCP2, Science, 302, 885, 10.1126\u002Fscience.1086446",{"doi":2599},"10.1126\u002Fscience.1086446",{"id":21,"text":2601,"url":21,"identifiers":2602},"Tohgi, 1999, Reduction with age in methylcytosine in the promoter region -224 approximately -101 of the amyloid precursor protein gene in autopsy human cortex, Mol. Brain Res., 70, 288, 10.1016\u002FS0169-328X(99)00163-1",{"doi":2603},"10.1016\u002FS0169-328X(99)00163-1",{"id":21,"text":2605,"url":21,"identifiers":2606},"Okano, 1998, Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases, Nat. Genet., 19, 219, 10.1038\u002F890",{"doi":2607},"10.1038\u002F890",{"id":21,"text":2609,"url":21,"identifiers":2610},"Okano, 1999, DNA methyltransferases DNMT3A and DNMT3B are essential for de novo methylation and mammalian development, Cell, 99, 247, 10.1016\u002FS0092-8674(00)81656-6",{"doi":2611},"10.1016\u002FS0092-8674(00)81656-6",{"id":21,"text":2613,"url":21,"identifiers":2614},"Klein, 2011, Mutations in dnmt1 cause hereditary sensory neuropathy with dementia and hearing loss, Nat. Genet., 43, 595, 10.1038\u002Fng.830",{"doi":2615},"10.1038\u002Fng.830",{"id":21,"text":2617,"url":21,"identifiers":2618},"Jurkowska, 2011, Structure and function of mammalian DNA methyltransferases, ChemBioChem, 12, 206, 10.1002\u002Fcbic.201000195",{"doi":2619},"10.1002\u002Fcbic.201000195",{"id":21,"text":2621,"url":21,"identifiers":2622},"Goll, 2005, Eukaryotic cytosine methyltransferases, Ann. Rev. Biochem., 74, 481, 10.1146\u002Fannurev.biochem.74.010904.153721",{"doi":2623},"10.1146\u002Fannurev.biochem.74.010904.153721",{"id":21,"text":2625,"url":21,"identifiers":2626},"Reik, 2001, Epigenetic reprogramming in mammalian development, Science, 293, 1089, 10.1126\u002Fscience.1063443",{"doi":2627},"10.1126\u002Fscience.1063443",{"id":21,"text":2629,"url":21,"identifiers":2630},"Reik, 2007, Stability and flexibility of epigenetic gene regulation in mammalian development, Nature, 447, 425, 10.1038\u002Fnature05918",{"doi":2631},"10.1038\u002Fnature05918",{"id":21,"text":2633,"url":21,"identifiers":2634},"Patil, 2014, The evidence for functional non-CpG methylation in mammalian cells, Epigenetics, 9, 823, 10.4161\u002Fepi.28741",{"doi":2635},"10.4161\u002Fepi.28741",{"id":21,"text":2637,"url":21,"identifiers":2638},"Ziller, M.J., Muller, F., Liao, J., Zhang, Y., Gu, H., Bock, C., Boyle, P., Epstein, C.B., Bernstein, B.E., and Lengauer, T. (2011). Genomic distribution and inter-sample variation of non-CpG methylation across human cell types. PLoS Genet., 7.",{"doi":2639},"10.1371\u002Fjournal.pgen.1002389",{"id":21,"text":2641,"url":21,"identifiers":2642},"Barres, 2009, Non-cpg methylation of the PGC-1alpha promoter through dnmt3b controls mitochondrial density, Cell Metabol., 10, 189, 10.1016\u002Fj.cmet.2009.07.011",{"doi":2643},"10.1016\u002Fj.cmet.2009.07.011",{"id":21,"text":2645,"url":21,"identifiers":2646},"Lister, 2011, Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells, Nature, 471, 68, 10.1038\u002Fnature09798",{"doi":2647},"10.1038\u002Fnature09798",{"id":21,"text":2649,"url":21,"identifiers":2650},"Ma, 2014, Abnormalities in human pluripotent cells due to reprogramming mechanisms, Nature, 511, 177, 10.1038\u002Fnature13551",{"doi":2651},"10.1038\u002Fnature13551",{"id":21,"text":2653,"url":21,"identifiers":2654},"Guo, 2014, Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain, Nat. Neurosci., 17, 215, 10.1038\u002Fnn.3607",{"doi":2655},"10.1038\u002Fnn.3607",{"id":21,"text":2657,"url":21,"identifiers":2658},"Barres, 2013, Weight loss after gastric bypass surgery in human obesity remodels promoter methylation, Cell Rep., 3, 1020, 10.1016\u002Fj.celrep.2013.03.018",{"doi":2659},"10.1016\u002Fj.celrep.2013.03.018",{"id":21,"text":2661,"url":21,"identifiers":2662},"Xie, 2012, Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome, Cell, 148, 816, 10.1016\u002Fj.cell.2011.12.035",{"doi":2663},"10.1016\u002Fj.cell.2011.12.035",{"id":21,"text":2665,"url":21,"identifiers":2666},"Inoue, 2005, Effects of methylation of non-CpG sequence in the promoter region on the expression of human synaptotagmin XI (syt11), Gene, 348, 123, 10.1016\u002Fj.gene.2004.12.044",{"doi":2667},"10.1016\u002Fj.gene.2004.12.044",{"id":21,"text":2669,"url":21,"identifiers":2670},"Guo, 2014, The DNA methylation landscape of human early embryos, Nature, 511, 606, 10.1038\u002Fnature13544",{"doi":2671},"10.1038\u002Fnature13544",{"id":21,"text":2673,"url":21,"identifiers":2674},"Tomizawa, 2011, Dynamic stage-specific changes in imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes, Development, 138, 811, 10.1242\u002Fdev.061416",{"doi":2675},"10.1242\u002Fdev.061416",{"id":21,"text":2677,"url":21,"identifiers":2678},"Varley, 2013, Dynamic DNA methylation across diverse human cell lines and tissues, Genome Res., 23, 555, 10.1101\u002Fgr.147942.112",{"doi":2679},"10.1101\u002Fgr.147942.112",{"id":21,"text":2681,"url":21,"identifiers":2682},"Zvetkova, 2005, Global hypomethylation of the genome in XX embryonic stem cells, Nat. Genet., 37, 1274, 10.1038\u002Fng1663",{"doi":2683},"10.1038\u002Fng1663",{"id":21,"text":2685,"url":21,"identifiers":2686},"Arand, J., Spieler, D., Karius, T., Branco, M.R., Meilinger, D., Meissner, A., Jenuwein, T., Xu, G., Leonhardt, H., and Wolf, V. (2012). In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases. PLoS Genet., 8.",{"doi":2687},"10.1371\u002Fjournal.pgen.1002750",{"id":21,"text":2689,"url":21,"identifiers":2690},"Ichiyanagi, 2013, Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development, Nucleic Acids Res., 41, 738, 10.1093\u002Fnar\u002Fgks1117",{"doi":2691},"10.1093\u002Fnar\u002Fgks1117",{"id":21,"text":2693,"url":21,"identifiers":2694},"Liao, 2015, Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells, Nat. Genet., 47, 469, 10.1038\u002Fng.3258",{"doi":2695},"10.1038\u002Fng.3258",{"id":21,"text":2697,"url":21,"identifiers":2698},"Pevsner, 2007, DNA methylation signatures within the human brain, Am. J. Hum. Genet., 81, 1304, 10.1086\u002F524110",{"doi":2699},"10.1086\u002F524110",{"id":21,"text":2701,"url":21,"identifiers":2702},"Kozlenkov, 2016, Substantial DNA methylation differences between two major neuronal subtypes in human brain, Nucleic acids Res., 44, 2593, 10.1093\u002Fnar\u002Fgkv1304",{"doi":2703},"10.1093\u002Fnar\u002Fgkv1304",{"id":21,"text":2705,"url":21,"identifiers":2706},"Guo, 2011, Neuronal activity modifies the DNA methylation landscape in the adult brain, Nat. Neurosci., 14, 1345, 10.1038\u002Fnn.2900",{"doi":2707},"10.1038\u002Fnn.2900",{"id":21,"text":2709,"url":21,"identifiers":2710},"Xie, 2013, Epigenomic analysis of multilineage differentiation of human embryonic stem cells, Cell, 153, 1134, 10.1016\u002Fj.cell.2013.04.022",{"doi":2711},"10.1016\u002Fj.cell.2013.04.022",{"id":21,"text":2713,"url":21,"identifiers":2714},"Reubinoff, 2000, Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro, Nat. Biotechnol., 18, 399, 10.1038\u002F74447",{"doi":2715},"10.1038\u002F74447",{"id":21,"text":2717,"url":21,"identifiers":2718},"Zhang, 2001, In vitro differentiation of transplantable neural precursors from human embryonic stem cells, Nat. Biotechnol., 19, 1129, 10.1038\u002Fnbt1201-1129",{"doi":2719},"10.1038\u002Fnbt1201-1129",{"id":21,"text":2721,"url":21,"identifiers":2722},"He, 2015, Non-CG methylation in the human genome, Ann. Rev. Genom. Hum. Genet., 16, 55, 10.1146\u002Fannurev-genom-090413-025437",{"doi":2723},"10.1146\u002Fannurev-genom-090413-025437",{"id":21,"text":2725,"url":21,"identifiers":2726},"Kozlenkov, 2014, Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites, Nucleic Acids Res., 42, 109, 10.1093\u002Fnar\u002Fgkt838",{"doi":2727},"10.1093\u002Fnar\u002Fgkt838",{"id":21,"text":2729,"url":21,"identifiers":2730},"Klose, 2006, Genomic DNA methylation: The mark and its mediators, Trends Biochem. Sci., 31, 89, 10.1016\u002Fj.tibs.2005.12.008",{"doi":2731},"10.1016\u002Fj.tibs.2005.12.008",{"id":21,"text":2733,"url":21,"identifiers":2734},"Shahbazian, 2002, Insight into rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation, Hum. Mol. Genet., 11, 115, 10.1093\u002Fhmg\u002F11.2.115",{"doi":2735},"10.1093\u002Fhmg\u002F11.2.115",{"id":21,"text":2737,"url":21,"identifiers":2738},"Guy, 2011, The role of MeCP2 in the brain, Ann. Rev. Cell Dev. Biol., 27, 631, 10.1146\u002Fannurev-cellbio-092910-154121",{"doi":2739},"10.1146\u002Fannurev-cellbio-092910-154121",{"id":21,"text":2741,"url":21,"identifiers":2742},"Kishi, 2004, MeCP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions, Mol. Cell. Neurosci., 27, 306, 10.1016\u002Fj.mcn.2004.07.006",{"doi":2743},"10.1016\u002Fj.mcn.2004.07.006",{"id":21,"text":2745,"url":21,"identifiers":2746},"Skene, 2010, Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state, Mol. Cell, 37, 457, 10.1016\u002Fj.molcel.2010.01.030",{"doi":2747},"10.1016\u002Fj.molcel.2010.01.030",{"id":21,"text":2749,"url":21,"identifiers":2750},"Nan, 1998, Transcriptional repression by the methyl-cpg-binding protein MeCP2 involves a histone deacetylase complex, Nature, 393, 386, 10.1038\u002F30764",{"doi":2751},"10.1038\u002F30764",{"id":21,"text":2753,"url":21,"identifiers":2754},"Jones, 1998, Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription, Nat. Genet., 19, 187, 10.1038\u002F561",{"doi":2755},"10.1038\u002F561",{"id":21,"text":2757,"url":21,"identifiers":2758},"Kriaucionis, 2009, The nuclear DNA base 5-hydroxymethylcytosine is present in purkinje neurons and the brain, Science, 324, 929, 10.1126\u002Fscience.1169786",{"doi":2759},"10.1126\u002Fscience.1169786",{"id":21,"text":2761,"url":21,"identifiers":2762},"Globisch, D., Munzel, M., Muller, M., Michalakis, S., Wagner, M., Koch, S., Bruckl, T., Biel, M., and Carell, T. (2010). Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates. PLoS ONE, 5.",{"doi":2763},"10.1371\u002Fjournal.pone.0015367",{"id":21,"text":2765,"url":21,"identifiers":2766},"Munzel, 2010, Quantification of the sixth DNA base hydroxymethylcytosine in the brain, Angew. Chem., 49, 5375, 10.1002\u002Fanie.201002033",{"doi":2767},"10.1002\u002Fanie.201002033",{"id":21,"text":2769,"url":21,"identifiers":2770},"Song, 2011, Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine, Nat. Biotechnol., 29, 68, 10.1038\u002Fnbt.1732",{"doi":2771},"10.1038\u002Fnbt.1732",{"id":21,"text":2773,"url":21,"identifiers":2774},"Dawlaty, 2011, TET1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development, Cell Stem Cell, 9, 166, 10.1016\u002Fj.stem.2011.07.010",{"doi":2775},"10.1016\u002Fj.stem.2011.07.010",{"id":21,"text":2777,"url":21,"identifiers":2778},"Hahn, 2013, Dynamics of 5-hydroxymethylcytosine and chromatin marks in mammalian neurogenesis, Cell Rep., 3, 291, 10.1016\u002Fj.celrep.2013.01.011",{"doi":2779},"10.1016\u002Fj.celrep.2013.01.011",{"id":21,"text":2781,"url":21,"identifiers":2782},"Zhang, 2013, TET1 regulates adult hippocampal neurogenesis and cognition, Cell Stem Cell, 13, 237, 10.1016\u002Fj.stem.2013.05.006",{"doi":2783},"10.1016\u002Fj.stem.2013.05.006",{"id":21,"text":2785,"url":21,"identifiers":2786},"Li, 2015, Critical role of tet3 in neural progenitor cell maintenance and terminal differentiation, Mol. Neurobiol., 51, 142, 10.1007\u002Fs12035-014-8734-5",{"doi":2787},"10.1007\u002Fs12035-014-8734-5",{"id":21,"text":2789,"url":21,"identifiers":2790},"Szwagierczak, 2010, Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA, Nucleic Acids Res., 38, e181, 10.1093\u002Fnar\u002Fgkq684",{"doi":2791},"10.1093\u002Fnar\u002Fgkq684",{"id":21,"text":2793,"url":21,"identifiers":2794},"Szulwach, K.E., Li, X., Li, Y., Song, C.X., Han, J.W., Kim, S., Namburi, S., Hermetz, K., Kim, J.J., and Rudd, M.K. (2011). Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells. PLoS Genet., 7.",{"doi":2795},"10.1371\u002Fjournal.pgen.1002154",{"id":21,"text":2797,"url":21,"identifiers":2798},"Ruzov, 2011, Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development, Cell Res., 21, 1332, 10.1038\u002Fcr.2011.113",{"doi":2799},"10.1038\u002Fcr.2011.113",{"id":21,"text":2801,"url":21,"identifiers":2802},"Tan, 2013, Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hmedip-seq method, Nucleic Acids Res., 41, e84, 10.1093\u002Fnar\u002Fgkt091",{"doi":2803},"10.1093\u002Fnar\u002Fgkt091",{"id":21,"text":2805,"url":21,"identifiers":2806},"Colquitt, 2013, Alteration of genic 5-hydroxymethylcytosine patterning in olfactory neurons correlates with changes in gene expression and cell identity, Proc. Natl. Acad. Sci. USA, 110, 14682, 10.1073\u002Fpnas.1302759110",{"doi":2807},"10.1073\u002Fpnas.1302759110",{"id":21,"text":2809,"url":21,"identifiers":2810},"Gan, 2013, Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis, Nat. Commun., 4, 1995, 10.1038\u002Fncomms2995",{"doi":2811},"10.1038\u002Fncomms2995",{"id":21,"text":2813,"url":21,"identifiers":2814},"Wen, 2014, Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain, Genome Biol., 15, R49, 10.1186\u002Fgb-2014-15-3-r49",{"doi":2815},"10.1186\u002Fgb-2014-15-3-r49",{"id":21,"text":2817,"url":21,"identifiers":2818},"Gabel, 2015, Disruption of DNA-methylation-dependent long gene repression in rett syndrome, Nature, 522, 89, 10.1038\u002Fnature14319",{"doi":2819},"10.1038\u002Fnature14319",{"id":21,"text":2821,"url":21,"identifiers":2822},"Spruijt, 2013, Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives, Cell, 152, 1146, 10.1016\u002Fj.cell.2013.02.004",{"doi":2823},"10.1016\u002Fj.cell.2013.02.004",{"id":21,"text":2825,"url":21,"identifiers":2826},"Minor, 2013, Ascorbate induces ten-eleven translocation (TET) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine, J. Biol. Chem., 288, 13669, 10.1074\u002Fjbc.C113.464800",{"doi":2827},"10.1074\u002Fjbc.C113.464800",{"id":21,"text":2829,"url":21,"identifiers":2830},"Spector, 2014, The nexus of vitamin homeostasis and DNA synthesis and modification in mammalian brain, Mol. Brain, 7, 3, 10.1186\u002F1756-6606-7-3",{"doi":2831},"10.1186\u002F1756-6606-7-3",{"id":21,"text":2833,"url":21,"identifiers":2834},"Sherwani, 2015, Role of 5-hydroxymethylcytosine in neurodegeneration, Gene, 570, 17, 10.1016\u002Fj.gene.2015.06.052",{"doi":2835},"10.1016\u002Fj.gene.2015.06.052",{"id":21,"text":2837,"url":21,"identifiers":2838},"Wheldon, 2014, Transient accumulation of 5-carboxylcytosine indicates involvement of active demethylation in lineage specification of neural stem cells, Cell Rep., 7, 1353, 10.1016\u002Fj.celrep.2014.05.003",{"doi":2839},"10.1016\u002Fj.celrep.2014.05.003",{"id":21,"text":2841,"url":21,"identifiers":2842},"Miller, 2007, Covalent modification of DNA regulates memory formation, Neuron, 53, 857, 10.1016\u002Fj.neuron.2007.02.022",{"doi":2843},"10.1016\u002Fj.neuron.2007.02.022",{"id":21,"text":2845,"url":21,"identifiers":2846},"Schanen, 2006, Epigenetics of autism spectrum disorders, Hum. Mol. Genet., 15, R138, 10.1093\u002Fhmg\u002Fddl213",{"doi":2847},"10.1093\u002Fhmg\u002Fddl213",{"id":21,"text":2849,"url":21,"identifiers":2850},"LaSalle, 2009, Evolving role of MeCP2 in rett syndrome and autism, Epigenomics, 1, 119, 10.2217\u002Fepi.09.13",{"doi":2851},"10.2217\u002Fepi.09.13",{"id":21,"text":2853,"url":21,"identifiers":2854},"Nicolia, 2017, DNA methylation profiles of selected pro-inflammatory cytokines in alzheimer disease, J. Neuropathol. Exp. Neurol., 76, 27",{},{"id":21,"text":2856,"url":21,"identifiers":2857},"Bird, 2002, DNA methylation patterns and epigenetic memory, Genes Dev., 16, 6, 10.1101\u002Fgad.947102",{"doi":2858},"10.1101\u002Fgad.947102",{"id":21,"text":2860,"url":21,"identifiers":2861},"Robertson, 2000, DNA methylation in health and disease, Nat. Rev. Genet., 1, 11, 10.1038\u002F35049533",{"doi":2862},"10.1038\u002F35049533",{"id":21,"text":2864,"url":21,"identifiers":2865},"Urdinguio, 2009, Epigenetic mechanisms in neurological diseases: Genes, syndromes, and therapies, Lancet Neurol., 8, 1056, 10.1016\u002FS1474-4422(09)70262-5",{"doi":2866},"10.1016\u002FS1474-4422(09)70262-5",{"id":21,"text":2868,"url":21,"identifiers":2869},"Iqbal, 2008, Alzheimer neurofibrillary degeneration: Significance, etiopathogenesis, therapeutics and prevention, J. Cell. Mol. Med., 12, 38, 10.1111\u002Fj.1582-4934.2008.00225.x",{"doi":2870},"10.1111\u002Fj.1582-4934.2008.00225.x",{"id":21,"text":2872,"url":21,"identifiers":2873},"Aso, 2013, DNA methylation map of mouse and human brain identifies target genes in Alzheimer’s disease, Brain, 136, 3018, 10.1093\u002Fbrain\u002Fawt237",{"doi":2874},"10.1093\u002Fbrain\u002Fawt237",{"id":21,"text":2876,"url":21,"identifiers":2877},"Blanch, 2016, Altered mitochondrial DNA methylation pattern in Alzheimer disease-related pathology and in parkinson disease, Am. J. Pathol., 186, 385, 10.1016\u002Fj.ajpath.2015.10.004",{"doi":2878},"10.1016\u002Fj.ajpath.2015.10.004",{"id":21,"text":2880,"url":21,"identifiers":2881},"Liu, 2016, Cpg methylation patterns of human mitochondrial DNA, Sci. Rep., 6, 23421, 10.1038\u002Fsrep23421",{"doi":2882},"10.1038\u002Fsrep23421",{"id":21,"text":2884,"url":21,"identifiers":2885},"Chouliaras, 2013, Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer’s disease patients, Neurobiol. Aging, 34, 2091, 10.1016\u002Fj.neurobiolaging.2013.02.021",{"doi":2886},"10.1016\u002Fj.neurobiolaging.2013.02.021",{"id":21,"text":2888,"url":21,"identifiers":2889},"Condliffe, 2014, Cross-region reduction in 5-hydroxymethylcytosine in alzheimer’s disease brain, Neurobiol. Aging, 35, 1850, 10.1016\u002Fj.neurobiolaging.2014.02.002",{"doi":2890},"10.1016\u002Fj.neurobiolaging.2014.02.002",{"id":21,"text":2892,"url":21,"identifiers":2893},"Coppieters, 2014, Global changes in DNA methylation and hydroxymethylation in Alzheimer’s disease human brain, Neurobiol. Aging, 35, 1334, 10.1016\u002Fj.neurobiolaging.2013.11.031",{"doi":2894},"10.1016\u002Fj.neurobiolaging.2013.11.031",{"id":21,"text":2896,"url":21,"identifiers":2897},"Lovell, 2013, Epigenetic changes in the progression of Alzheimer’s disease, Mech. Ageing Dev., 134, 486, 10.1016\u002Fj.mad.2013.08.005",{"doi":2898},"10.1016\u002Fj.mad.2013.08.005",{"id":21,"text":2900,"url":21,"identifiers":2901},"Hagberg, 1985, Rett’s syndrome: Prevalence and impact on progressive severe mental retardation in girls, Acta Paediatr. Scand., 74, 405, 10.1111\u002Fj.1651-2227.1985.tb10993.x",{"doi":2902},"10.1111\u002Fj.1651-2227.1985.tb10993.x",{"id":21,"text":2904,"url":21,"identifiers":2905},"Rett, 1966, On a unusual brain atrophy syndrome in hyperammonemia in childhood, Wiener Medizinische Wochenschrift, Volume 116, 723",{},{"id":21,"text":2907,"url":21,"identifiers":2908},"Martinowich, 2003, DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation, Science, 302, 890, 10.1126\u002Fscience.1090842",{"doi":2909},"10.1126\u002Fscience.1090842",{"id":21,"text":2911,"url":21,"identifiers":2912},"Nuber, 2005, Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome, Hum. Mol. Genet., 14, 2247, 10.1093\u002Fhmg\u002Fddi229",{"doi":2913},"10.1093\u002Fhmg\u002Fddi229",{"id":21,"text":2915,"url":21,"identifiers":2916},"Horike, 2005, Loss of silent-chromatin looping and impaired imprinting of Dlx5 in Rett syndrome, Nat. Genet., 37, 31, 10.1038\u002Fng1491",{"doi":2917},"10.1038\u002Fng1491",{"id":21,"text":2919,"url":21,"identifiers":2920},"Klose, 2005, DNA binding selectivity of MeCP2 due to a requirement for A\u002FT sequences adjacent to methyl-CpG, Mol. Cell, 19, 667, 10.1016\u002Fj.molcel.2005.07.021",{"doi":2921},"10.1016\u002Fj.molcel.2005.07.021",{"id":21,"text":2923,"url":21,"identifiers":2924},"Makedonski, 2005, MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS\u002FAS imprinting center that affects UBE3A expression, Hum. Mol. Genet., 14, 1049, 10.1093\u002Fhmg\u002Fddi097",{"doi":2925},"10.1093\u002Fhmg\u002Fddi097",{"id":21,"text":2927,"url":21,"identifiers":2928},"Amir, 1999, Rett syndrome is caused by mutations in X-linked MeCP2, encoding methyl-CpG-binding protein 2, Nat. Genet., 23, 185, 10.1038\u002F13810",{"doi":2929},"10.1038\u002F13810",{"id":21,"text":2931,"url":21,"identifiers":2932},"Chen, 2015, MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome, Proc. Natl. Acad. Sci. USA, 112, 5509, 10.1073\u002Fpnas.1505909112",{"doi":2933},"10.1073\u002Fpnas.1505909112",{"id":21,"text":2935,"url":21,"identifiers":2936},"Irwin, 2000, Dendritic spine structural anomalies in fragile-X mental retardation syndrome, Cereb. Cortex, 10, 1038, 10.1093\u002Fcercor\u002F10.10.1038",{"doi":2937},"10.1093\u002Fcercor\u002F10.10.1038",{"id":21,"text":2939,"url":21,"identifiers":2940},"Huber, 2002, Altered synaptic plasticity in a mouse model of fragile X mental retardation, Proc. Natl. Acad. Sci. USA, 99, 7746, 10.1073\u002Fpnas.122205699",{"doi":2941},"10.1073\u002Fpnas.122205699",{"id":21,"text":2943,"url":21,"identifiers":2944},"Garber, 2008, Fragile X syndrome, Eur. J. Hum. Genet., 16, 666, 10.1038\u002Fejhg.2008.61",{"doi":2945},"10.1038\u002Fejhg.2008.61",{"id":21,"text":2947,"url":21,"identifiers":2948},"Mostofsky, 1998, Decreased cerebellar posterior vermis size in fragile X syndrome: Correlation with neurocognitive performance, Neurology, 50, 121, 10.1212\u002FWNL.50.1.121",{"doi":2949},"10.1212\u002FWNL.50.1.121",{"id":21,"text":2951,"url":21,"identifiers":2952},"Nolin, 1996, Familial transmission of the FMR1 CgG repeat, Am. J. Hum. Genet., 59, 1252",{},{"id":21,"text":2954,"url":21,"identifiers":2955},"Kremer, 1991, Mapping of DNA instability at the fragile x to a trinucleotide repeat sequence p (CcG) n, Science, 252, 1711, 10.1126\u002Fscience.1675488",{"doi":2956},"10.1126\u002Fscience.1675488",{"id":21,"text":2958,"url":21,"identifiers":2959},"Oberle, 1991, Instability of a 550-base pair DNA segment and abnormal methylation in fragile x syndrome, Science, 252, 1097, 10.1126\u002Fscience.252.5009.1097",{"doi":2960},"10.1126\u002Fscience.252.5009.1097",{"id":21,"text":2962,"url":21,"identifiers":2963},"Coffee, 1999, Acetylated histones are associated with fmr1 in normal but not fragile X-syndrome cells, Nat. Genet., 22, 98, 10.1038\u002F8807",{"doi":2964},"10.1038\u002F8807",{"id":21,"text":2966,"url":21,"identifiers":2967},"Tabolacci, E., Palumbo, F., Nobile, V., and Neri, G. (2016). Transcriptional reactivation of the fmr1 gene. A possible approach to the treatment of the fragile X syndrome. Genes, 7.",{"doi":2968},"10.3390\u002Fgenes7080049",{"id":21,"text":2970,"url":21,"identifiers":2971},"Lees, 2009, Parkinson’s disease, Lancet, 373, 2055, 10.1016\u002FS0140-6736(09)60492-X",{"doi":2972},"10.1016\u002FS0140-6736(09)60492-X",{"id":21,"text":2974,"url":21,"identifiers":2975},"Volta, 2015, Insights from late-onset familial parkinsonism on the pathogenesis of idiopathic parkinson’s disease, Lancet Neurol., 14, 1054, 10.1016\u002FS1474-4422(15)00186-6",{"doi":2976},"10.1016\u002FS1474-4422(15)00186-6",{"id":21,"text":2978,"url":21,"identifiers":2979},"Grundemann, 2008, Elevated alpha-synuclein mrna levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic parkinson’s disease, Nucleic Acids Res., 36, e38, 10.1093\u002Fnar\u002Fgkn084",{"doi":2980},"10.1093\u002Fnar\u002Fgkn084",{"id":21,"text":2982,"url":21,"identifiers":2983},"Schmitt, 2015, L-dopa increases alpha-synuclein DNA methylation in parkinson’s disease patients in vivo and in vitro, Mov. Disord., 30, 1794, 10.1002\u002Fmds.26319",{"doi":2984},"10.1002\u002Fmds.26319",{"id":21,"text":2986,"url":21,"identifiers":2987},"Zhang, 2016, Reduced plasma taurine level in parkinson’s disease: Association with motor severity and levodopa treatment, Int. J. Neurosci., 126, 630",{},{"id":21,"text":2989,"url":21,"identifiers":2990},"Desplats, 2011, Alpha-synuclein sequesters DNMT1 from the nucleus: A novel mechanism for epigenetic alterations in lewy body diseases, J. Biol. Chem., 286, 9031, 10.1074\u002Fjbc.C110.212589",{"doi":2991},"10.1074\u002Fjbc.C110.212589",{"id":21,"text":2993,"url":21,"identifiers":2994},"Carvey, 2005, Intra-parenchymal injection of tumor necrosis factor-alpha and interleukin 1-beta produces dopamine neuron loss in the rat, J. Neural Transm., 112, 601, 10.1007\u002Fs00702-004-0222-z",{"doi":2995},"10.1007\u002Fs00702-004-0222-z",{"id":21,"text":2997,"url":21,"identifiers":2998},"Pieper, 2008, Different methylation of the tnf-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability, Neurobiol. Dis., 32, 521, 10.1016\u002Fj.nbd.2008.09.010",{"doi":2999},"10.1016\u002Fj.nbd.2008.09.010",{"id":21,"text":3001,"url":21,"identifiers":3002},"Pringsheim, 2012, The incidence and prevalence of Huntington’s disease: A systematic review and meta-analysis, Mov. Disord., 27, 1083, 10.1002\u002Fmds.25075",{"doi":3003},"10.1002\u002Fmds.25075",{"id":21,"text":3005,"url":21,"identifiers":3006},"MacDonald, 1993, A novel gene containing a trinucleotide repeat that is expanded and unstable on huntington’s disease chromosomes, Cell, 72, 971, 10.1016\u002F0092-8674(93)90585-E",{"doi":3007},"10.1016\u002F0092-8674(93)90585-E",{"id":21,"text":3009,"url":21,"identifiers":3010},"Kremer, 1994, A worldwide study of the Huntington’s disease mutation: The sensitivity and specificity of measuring cag repeats, N. Engl. J. Med., 330, 1401, 10.1056\u002FNEJM199405193302001",{"doi":3011},"10.1056\u002FNEJM199405193302001",{"id":21,"text":3013,"url":21,"identifiers":3014},"Islam, 2016, DNA methylation profiling in human Huntington’s disease brain, Hum. Mol. Genet., 25, 2013, 10.1093\u002Fhmg\u002Fddw076",{"doi":3015},"10.1093\u002Fhmg\u002Fddw076",{"id":21,"text":3017,"url":21,"identifiers":3018},"Blanch, 2013, Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington’s disease, Neuromol. Med., 15, 295, 10.1007\u002Fs12017-013-8219-0",{"doi":3019},"10.1007\u002Fs12017-013-8219-0",{"id":21,"text":3021,"url":21,"identifiers":3022},"Thomas, 2013, A novel method for detecting 7-methyl guanine reveals aberrant methylation levels in Huntington disease, Anal. Biochem., 436, 112, 10.1016\u002Fj.ab.2013.01.035",{"doi":3023},"10.1016\u002Fj.ab.2013.01.035",{"id":21,"text":3025,"url":21,"identifiers":3026},"Wang, 2013, Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington’s disease, Hum. Mol. Genet., 22, 3641, 10.1093\u002Fhmg\u002Fddt214",{"doi":3027},"10.1093\u002Fhmg\u002Fddt214",{"id":21,"text":3029,"url":21,"identifiers":3030},"Bai, 2014, Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains, Hum. Mol. Genet., 24, 1441, 10.1093\u002Fhmg\u002Fddu561",{"doi":3031},"10.1093\u002Fhmg\u002Fddu561",{"id":21,"text":3033,"url":21,"identifiers":3034},"McFarland, 2014, MeCP2: A novel huntingtin interactor, Hum. Mol. Genet., 23, 1036, 10.1093\u002Fhmg\u002Fddt499",{"doi":3035},"10.1093\u002Fhmg\u002Fddt499",{"id":21,"text":3037,"url":21,"identifiers":3038},"Rowland, 2001, Amyotrophic lateral sclerosis, N. Engl. J. 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It is estimated that the prevalence of knee osteoarthritis (OA) among adults 60 years of age or older is approximately 10% in men and 13% in women, making knee OA one of the leading causes of disability in elderly population. Today, we know that osteoarthritis is not a disease characterized by loss of cartilage due to mechanical loading only, but a condition that affects all of the tissues in the joint, causing detectable changes in tissue architecture, its metabolism and function. All of these changes are mediated by a complex and not yet fully researched interplay of proinflammatory and anti-inflammatory cytokines, chemokines, growth factors and adipokines, all of which can be measured in the serum, synovium and histological samples, potentially serving as biomarkers of disease stage and progression. Another key aspect of disease progression is the epigenome that regulates all the genetic expression through DNA methylation, histone modifications, and mRNA interference. A lot of work has been put into developing non-surgical treatment options to slow down the natural course of osteoarthritis to postpone, or maybe even replace extensive surgeries such as total knee arthroplasty. At the moment, biological treatments such as platelet-rich plasma, bone marrow mesenchymal stem cells and autologous microfragmented adipose tissue containing stromal vascular fraction are ordinarily used. Furthermore, the latter two mentioned cell-based treatment options seem to be the only methods so far that increase the quality of cartilage in osteoarthritis patients. Yet, in the future, gene therapy could potentially become an option for orthopedic patients. 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2018, Osteoarthritis and its management—Epidemiology, nutritional aspects and environmental factors, Autoimmun. Rev., 17, 1097, 10.1016\u002Fj.autrev.2018.06.002",{"doi":3504},"10.1016\u002Fj.autrev.2018.06.002",{"id":21,"text":3506,"url":21,"identifiers":3507},"Mabey, 2015, Cytokines as biochemical markers for knee osteoarthritis, World J. Orthop., 6, 95, 10.5312\u002Fwjo.v6.i1.95",{"doi":3508},"10.5312\u002Fwjo.v6.i1.95",{"id":21,"text":3510,"url":21,"identifiers":3511},"Nelson, 2018, Osteoarthritis year in review 2017: Clinical, Osteoarthr. Cartil., 26, 319, 10.1016\u002Fj.joca.2017.11.014",{"doi":3512},"10.1016\u002Fj.joca.2017.11.014",{"id":21,"text":3514,"url":21,"identifiers":3515},"Loeser, 2012, Osteoarthritis: A disease of the joint as an organ, Arthritis Rheum., 64, 1697, 10.1002\u002Fart.34453",{"doi":3516},"10.1002\u002Fart.34453",{"id":21,"text":3518,"url":21,"identifiers":3519},"Barr, 2016, Osteoarthritis, Nat. Rev. Dis. Prim., 2, 1",{},{"id":21,"text":3521,"url":21,"identifiers":3522},"Swingler, 2019, The function of microRNAs in cartilage and osteoarthritis, Clin. Exp. Rheumatol., 37, 40",{},{"id":21,"text":3524,"url":21,"identifiers":3525},"Ilas, 2017, Targeting subchondral bone mesenchymal stem cell activities for intrinsic joint repair in osteoarthritis, Futur. Sci. OA, 3, FSO228, 10.4155\u002Ffsoa-2017-0055",{"doi":3526},"10.4155\u002Ffsoa-2017-0055",{"id":21,"text":3528,"url":21,"identifiers":3529},"Hunter, 2019, Osteoarthritis, Lancet, 393, 1745, 10.1016\u002FS0140-6736(19)30417-9",{"doi":3530},"10.1016\u002FS0140-6736(19)30417-9",{"id":21,"text":3532,"url":21,"identifiers":3533},"Carlson, 2019, Characterization of synovial fluid metabolomic phenotypes of cartilage morphological changes associated with osteoarthritis, Osteoarthr. Cartil., 27, 1174, 10.1016\u002Fj.joca.2019.04.007",{"doi":3534},"10.1016\u002Fj.joca.2019.04.007",{"id":21,"text":3536,"url":21,"identifiers":3537},"Nguyen, 2011, Increasing Prevalence of Knee Pain and Symptomatic Knee Osteoarthritis: Survey and Cohort Data, Ann. Intern. Med., 155, 725, 10.7326\u002F0003-4819-155-11-201112060-00004",{"doi":3538},"10.7326\u002F0003-4819-155-11-201112060-00004",{"id":21,"text":3540,"url":21,"identifiers":3541},"Zhang, 2010, Epidemiology of Osteoarthritis, Clin. Geriatr. Med., 26, 355, 10.1016\u002Fj.cger.2010.03.001",{"doi":3542},"10.1016\u002Fj.cger.2010.03.001",{"id":21,"text":3544,"url":21,"identifiers":3545},"(2016). GBD 2015 Disease and Injury Incidence and Prevalence Collaborators Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet, 388, 1545–1602.",{},{"id":21,"text":3547,"url":21,"identifiers":3548},"Prince, 2015, The burden of disease in older people and implications for health policy and practice, Lancet, 385, 549, 10.1016\u002FS0140-6736(14)61347-7",{"doi":3549},"10.1016\u002FS0140-6736(14)61347-7",{"id":21,"text":3551,"url":21,"identifiers":3552},"Loeser, 2010, Why is osteoarthritis an age-related disease?, Best Pract. Res. Clin. Rheumatol., 24, 15, 10.1016\u002Fj.berh.2009.08.006",{"doi":3553},"10.1016\u002Fj.berh.2009.08.006",{"id":21,"text":3555,"url":21,"identifiers":3556},"Felson, 2013, Osteoarthritis as a disease of mechanics, Osteoarthr. Cartil., 21, 10, 10.1016\u002Fj.joca.2012.09.012",{"doi":3557},"10.1016\u002Fj.joca.2012.09.012",{"id":21,"text":3559,"url":21,"identifiers":3560},"Vina, 2018, Epidemiology of osteoarthritis, Curr. Opin. Rheumatol., 30, 160, 10.1097\u002FBOR.0000000000000479",{"doi":3561},"10.1097\u002FBOR.0000000000000479",{"id":21,"text":3563,"url":21,"identifiers":3564},"Harris, 2015, HIP osteoarthritis and work, Best Pract. Res. Clin. Rheumatol., 29, 462, 10.1016\u002Fj.berh.2015.04.015",{"doi":3565},"10.1016\u002Fj.berh.2015.04.015",{"id":21,"text":3567,"url":21,"identifiers":3568},"Ezzat, 2014, Occupational Physical Loading Tasks and Knee Osteoarthritis: A Review of the Evidence, Physiother. Can., 66, 91, 10.3138\u002Fptc.2012-45BC",{"doi":3569},"10.3138\u002Fptc.2012-45BC",{"id":21,"text":3571,"url":21,"identifiers":3572},"Driban, 2017, Is Participation in Certain Sports Associated With Knee Osteoarthritis? A Systematic Review, J. Athl. Train., 52, 497, 10.4085\u002F1062-6050-50.2.08",{"doi":3573},"10.4085\u002F1062-6050-50.2.08",{"id":21,"text":3575,"url":21,"identifiers":3576},"Berenbaum, 2018, Modern-day environmental factors in the pathogenesis of osteoarthritis, Nat. Rev. Rheumatol., 14, 674, 10.1038\u002Fs41584-018-0073-x",{"doi":3577},"10.1038\u002Fs41584-018-0073-x",{"id":21,"text":3579,"url":21,"identifiers":3580},"Hame, 2013, Knee osteoarthritis in women, Curr. Rev. Musculoskelet. Med., 6, 182, 10.1007\u002Fs12178-013-9164-0",{"doi":3581},"10.1007\u002Fs12178-013-9164-0",{"id":21,"text":3583,"url":21,"identifiers":3584},"Long, 2020, Burden of osteoarthritis in China, 1990–2017: Findings from the Global Burden of Disease Study 2017, Lancet Rheumatol., 2, e164, 10.1016\u002FS2665-9913(19)30145-6",{"doi":3585},"10.1016\u002FS2665-9913(19)30145-6",{"id":21,"text":3587,"url":21,"identifiers":3588},"Wang, 2016, Osteoarthritis and the risk of cardiovascular disease: A meta-analysis of observational studies, Sci. Rep., 6, 1, 10.1038\u002Fsrep39672",{"doi":3589},"10.1038\u002Fsrep39672",{"id":21,"text":3591,"url":21,"identifiers":3592},"Wallace, 2017, Knee osteoarthritis has doubled in prevalence since the mid-20th century, Proc. Natl. Acad. Sci. USA, 114, 9332, 10.1073\u002Fpnas.1703856114",{"doi":3593},"10.1073\u002Fpnas.1703856114",{"id":21,"text":3595,"url":21,"identifiers":3596},"Veronese, 2016, Osteoarthritis and mortality: A prospective cohort study and systematic review with meta-analysis, Semin. Arthritis Rheum., 46, 160, 10.1016\u002Fj.semarthrit.2016.04.002",{"doi":3597},"10.1016\u002Fj.semarthrit.2016.04.002",{"id":21,"text":3599,"url":21,"identifiers":3600},"Bianco, D., Todorov, A., Čengić, T., Pagenstert, G., Schären, S., Netzer, C., Hügle, T., and Geurts, J. (2018). Alterations of Subchondral Bone Progenitor Cells in Human Knee and Hip Osteoarthritis Lead to a Bone Sclerosis Phenotype. Int. J. Mol. Sci., 19.",{"doi":3601},"10.3390\u002Fijms19020475",{"id":21,"text":3603,"url":21,"identifiers":3604},"Reynard, 2020, Osteoarthritis year in review 2019: Genetics, genomics and epigenetics, Osteoarthr. Cartil., 28, 275, 10.1016\u002Fj.joca.2019.11.010",{"doi":3605},"10.1016\u002Fj.joca.2019.11.010",{"id":21,"text":3607,"url":21,"identifiers":3608},"Rice, 2020, Interplay between genetics and epigenetics in osteoarthritis, Nat. Rev. Rheumatol., 16, 268, 10.1038\u002Fs41584-020-0407-3",{"doi":3609},"10.1038\u002Fs41584-020-0407-3",{"id":21,"text":3611,"url":21,"identifiers":3612},"Emery, 2019, Establishing outcome measures in early knee osteoarthritis, Nat. Rev. Rheumatol., 15, 438, 10.1038\u002Fs41584-019-0237-3",{"doi":3613},"10.1038\u002Fs41584-019-0237-3",{"id":21,"text":3615,"url":21,"identifiers":3616},"Xia, 2014, Osteoarthritis Pathogenesis: A Review of Molecular Mechanisms, Calcif. Tissue Int., 95, 495, 10.1007\u002Fs00223-014-9917-9",{"doi":3617},"10.1007\u002Fs00223-014-9917-9",{"id":21,"text":3619,"url":21,"identifiers":3620},"Goldring, 2016, Changes in the osteochondral unit during osteoarthritis: Structure, function and cartilage bone crosstalk, Nat. Rev. Rheumatol., 12, 632, 10.1038\u002Fnrrheum.2016.148",{"doi":3621},"10.1038\u002Fnrrheum.2016.148",{"id":21,"text":3623,"url":21,"identifiers":3624},"Carballo, 2017, Basic Science of Articular Cartilage, Clin. Sports Med., 36, 413, 10.1016\u002Fj.csm.2017.02.001",{"doi":3625},"10.1016\u002Fj.csm.2017.02.001",{"id":21,"text":3627,"url":21,"identifiers":3628},"Primorac, 1994, Molecular basis of nanomelia, a heritable chondrodystrophy of chicken, Matrix Biol., 14, 297, 10.1016\u002F0945-053X(94)90195-3",{"doi":3629},"10.1016\u002F0945-053X(94)90195-3",{"id":21,"text":3631,"url":21,"identifiers":3632},"Primorac, 1995, Reduced Type II collagen mRNA in nanomelic cultured chondrocytes: An example of extracellular matrix\u002Fcollagen feedback regulation?, Croat. Med. J., 36, 85",{},{"id":21,"text":3634,"url":21,"identifiers":3635},"Primorac, 1999, Premature termination codon in the aggrecan gene of nanomelia and its influence on mRNA transport and stability, Croat. Med. J., 40, 528",{},{"id":21,"text":3637,"url":21,"identifiers":3638},"Houard, 2013, Homeostatic Mechanisms in Articular Cartilage and Role of Inflammation in Osteoarthritis, Curr. Rheumatol. Rep., 15, 375, 10.1007\u002Fs11926-013-0375-6",{"doi":3639},"10.1007\u002Fs11926-013-0375-6",{"id":21,"text":3641,"url":21,"identifiers":3642},"Goldring, 2009, Cartilage homeostasis in health and rheumatic diseases, Arthritis Res. Ther., 11, 224, 10.1186\u002Far2592",{"doi":3643},"10.1186\u002Far2592",{"id":21,"text":3645,"url":21,"identifiers":3646},"Musumeci, 2016, The Effect of Mechanical Loading on Articular Cartilage, J. Funct. Morphol. Kinesiol., 1, 154, 10.3390\u002Fjfmk1020154",{"doi":3647},"10.3390\u002Fjfmk1020154",{"id":21,"text":3649,"url":21,"identifiers":3650},"Jacobs, C.R., Huang, H., and Kwon, R.Y. (2012). Introduction to Cell Mechanics and Mechanobiology, Garland Science.",{"doi":3651},"10.1201\u002F9781135042653",{"id":21,"text":3653,"url":21,"identifiers":3654},"Vanwanseele, 2003, Longitudinal Analysis of Cartilage Atrophy in the Knees of Patients with Spinal Cord Injury, Arthritis Rheum., 48, 3377, 10.1002\u002Fart.11367",{"doi":3655},"10.1002\u002Fart.11367",{"id":21,"text":3657,"url":21,"identifiers":3658},"Mansfield, 2019, Collagen reorganization in cartilage under strain probed by polarization sensitive second harmonic generation microscopy, J. R. Soc. Interface, 16, 20180611, 10.1098\u002Frsif.2018.0611",{"doi":3659},"10.1098\u002Frsif.2018.0611",{"id":21,"text":3661,"url":21,"identifiers":3662},"Mansfield, 2015, The micromechanics of the superficial zone of articular cartilage, Osteoarthr. Cartil., 23, 1806, 10.1016\u002Fj.joca.2015.05.030",{"doi":3663},"10.1016\u002Fj.joca.2015.05.030",{"id":21,"text":3665,"url":21,"identifiers":3666},"Korhonen, 2008, Importance of Collagen Orientation and Depth-Dependent Fixed Charge Densities of Cartilage on Mechanical Behavior of Chondrocytes, J. Biomech. Eng., 130, 021003, 10.1115\u002F1.2898725",{"doi":3667},"10.1115\u002F1.2898725",{"id":21,"text":3669,"url":21,"identifiers":3670},"Wilson, 2006, Prediction of collagen orientation in articular cartilage by a collagen remodeling algorithm, Osteoarthr. Cartil., 14, 1196, 10.1016\u002Fj.joca.2006.05.006",{"doi":3671},"10.1016\u002Fj.joca.2006.05.006",{"id":21,"text":3673,"url":21,"identifiers":3674},"Wu, 2008, Study of the collagen structure in the superficial zone and physiological state of articular cartilage using a 3D confocal imaging technique, J. Orthop. Surg. Res., 3, 29, 10.1186\u002F1749-799X-3-29",{"doi":3675},"10.1186\u002F1749-799X-3-29",{"id":21,"text":3677,"url":21,"identifiers":3678},"Mansfield, 2012, A multi-modal multiphoton investigation of microstructure in the deep zone and calcified cartilage, J. Anat., 220, 405, 10.1111\u002Fj.1469-7580.2012.01479.x",{"doi":3679},"10.1111\u002Fj.1469-7580.2012.01479.x",{"id":21,"text":3681,"url":21,"identifiers":3682},"Ruhlen, 2014, The chondrocyte primary cilium, Osteoarthr. Cartil., 22, 1071, 10.1016\u002Fj.joca.2014.05.011",{"doi":3683},"10.1016\u002Fj.joca.2014.05.011",{"id":21,"text":3685,"url":21,"identifiers":3686},"Goldring, 2010, Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis, Ann. N. Y Acad. Sci., 1192, 230, 10.1111\u002Fj.1749-6632.2009.05240.x",{"doi":3687},"10.1111\u002Fj.1749-6632.2009.05240.x",{"id":21,"text":3689,"url":21,"identifiers":3690},"Stanton, 2005, ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro, Nature, 434, 648, 10.1038\u002Fnature03417",{"doi":3691},"10.1038\u002Fnature03417",{"id":21,"text":3693,"url":21,"identifiers":3694},"Pratta, 2006, Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments, Osteoarthr. Cartil., 14, 702, 10.1016\u002Fj.joca.2006.01.012",{"doi":3695},"10.1016\u002Fj.joca.2006.01.012",{"id":21,"text":3697,"url":21,"identifiers":3698},"Loeser, 2006, Molecular mechanisms of cartilage destruction: Mechanics, inflammatory mediators, and aging collide, Arthritis Rheum., 54, 1357, 10.1002\u002Fart.21813",{"doi":3699},"10.1002\u002Fart.21813",{"id":21,"text":3701,"url":21,"identifiers":3702},"Parrish, A.R. (2017). Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Target Tissues and Therapy, Elsevier. [1st ed.].",{},{"id":21,"text":3704,"url":21,"identifiers":3705},"Rolauffs, 2010, Proliferative Remodeling of the Spatial Organization of Human Superficial Chondrocytes Distant From Focal Early Osteoarthritis, Arthritis Rheum. Off. J. Am. Coll. Rheum., 62, 489",{},{"id":21,"text":3707,"url":21,"identifiers":3708},"Palmer, 2015, Osteoarthritis, Lancet, 386, 376, 10.1016\u002FS0140-6736(14)60802-3",{"doi":3709},"10.1016\u002FS0140-6736(14)60802-3",{"id":21,"text":3711,"url":21,"identifiers":3712},"Zhen, 2014, Targeting TGFβ signaling in subchondral bone and articular cartilage homeostasis, Trends Pharmacol. Sci., 35, 227, 10.1016\u002Fj.tips.2014.03.005",{"doi":3713},"10.1016\u002Fj.tips.2014.03.005",{"id":21,"text":3715,"url":21,"identifiers":3716},"Li, 2013, Subchondral bone in osteoarthritis: Insight into risk factors and microstructural changes, Arthritis Res. Ther., 15, 223, 10.1186\u002Far4405",{"doi":3717},"10.1186\u002Far4405",{"id":21,"text":3719,"url":21,"identifiers":3720},"2015, Subchondral bone and osteoarthritis, Curr. Opin. Rheumatol., 27, 420, 10.1097\u002FBOR.0000000000000181",{"doi":3721},"10.1097\u002FBOR.0000000000000181",{"id":21,"text":3723,"url":21,"identifiers":3724},"Sanchez, 2012, Regulation of subchondral bone osteoblast metabolism by cyclic compression, Arthritis Rheum., 64, 1193, 10.1002\u002Fart.33445",{"doi":3725},"10.1002\u002Fart.33445",{"id":21,"text":3727,"url":21,"identifiers":3728},"Burr, 2012, Bone remodelling in osteoarthritis, Nat. Rev. Rheumatol., 8, 665, 10.1038\u002Fnrrheum.2012.130",{"doi":3729},"10.1038\u002Fnrrheum.2012.130",{"id":21,"text":3731,"url":21,"identifiers":3732},"Goldring, 2009, Role of Bone in Osteoarthritis Pathogenesis, Med. Clin. N. Am., 93, 25, 10.1016\u002Fj.mcna.2008.09.006",{"doi":3733},"10.1016\u002Fj.mcna.2008.09.006",{"id":21,"text":3735,"url":21,"identifiers":3736},"Driban, 2012, Bone marrow lesions are associated with altered trabecular morphometry, Osteoarthr. Cartil., 20, 1519, 10.1016\u002Fj.joca.2012.08.013",{"doi":3737},"10.1016\u002Fj.joca.2012.08.013",{"id":21,"text":3739,"url":21,"identifiers":3740},"Bowes, 2016, Osteoarthritic bone marrow lesions almost exclusively colocate with denuded cartilage: A 3D study using data from the Osteoarthritis Initiative, Ann. Rheum. Dis., 75, 1852, 10.1136\u002Fannrheumdis-2015-208407",{"doi":3741},"10.1136\u002Fannrheumdis-2015-208407",{"id":21,"text":3743,"url":21,"identifiers":3744},"Cotofana, 2013, Relationship between knee pain and the presence, location, size and phenotype offemorotibial denuded areas of subchondral bone as visualized by MRI, Osteoarthr. Cartil., 21, 1214, 10.1016\u002Fj.joca.2013.04.001",{"doi":3745},"10.1016\u002Fj.joca.2013.04.001",{"id":21,"text":3747,"url":21,"identifiers":3748},"Crema, 2010, Subchondral cystlike lesions develop longitudinally in areas of bone marrow edema-like lesions in patients with or at risk for knee osteoarthritis: Detection with MR imaging—The MOST study, Radiology, 256, 855, 10.1148\u002Fradiol.10091467",{"doi":3749},"10.1148\u002Fradiol.10091467",{"id":21,"text":3751,"url":21,"identifiers":3752},"Yang, 2020, Comparison of early-stage changes of osteoarthritis in cartilage and subchondral bone between two different rat models, PeerJ, 8, e8934, 10.7717\u002Fpeerj.8934",{"doi":3753},"10.7717\u002Fpeerj.8934",{"id":21,"text":3755,"url":21,"identifiers":3756},"Crema, 2014, The relationship between subchondral sclerosis detected with MRI and cartilage loss in a cohort of subjects with knee pain: The knee osteoarthritis progression (KOAP) study, Osteoarthr. Cartil., 22, 540, 10.1016\u002Fj.joca.2014.01.006",{"doi":3757},"10.1016\u002Fj.joca.2014.01.006",{"id":21,"text":3759,"url":21,"identifiers":3760},"Wenham, 2010, The role of synovitis in osteoarthritis, Ther. Adv. Musculoskelet. Dis., 2, 349, 10.1177\u002F1759720X10378373",{"doi":3761},"10.1177\u002F1759720X10378373",{"id":21,"text":3763,"url":21,"identifiers":3764},"Schmidt, 2007, Boundary lubrication of articular cartilage: Role of synovial fluid constituents, Arthritis Rheum., 56, 882, 10.1002\u002Fart.22446",{"doi":3765},"10.1002\u002Fart.22446",{"id":21,"text":3767,"url":21,"identifiers":3768},"Griffin, 2019, Innate inflammation and synovial macrophages in osteoarthritis pathophysiology, Clin. Exp. Rheumatol., 37, 57",{},{"id":21,"text":3770,"url":21,"identifiers":3771},"Belluzzi, 2019, Contribution of Infrapatellar Fat Pad and Synovial Membrane to Knee Osteoarthritis Pain, Biomed. Res. Int., 2019, 1, 10.1155\u002F2019\u002F6390182",{"doi":3772},"10.1155\u002F2019\u002F6390182",{"id":21,"text":3774,"url":21,"identifiers":3775},"Sellam, 2010, The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis, Nat. Rev. Rheumatol., 6, 625, 10.1038\u002Fnrrheum.2010.159",{"doi":3776},"10.1038\u002Fnrrheum.2010.159",{"id":21,"text":3778,"url":21,"identifiers":3779},"Xie, 2019, Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee, Cytokine Growth Factor Rev., 46, 36, 10.1016\u002Fj.cytogfr.2019.03.004",{"doi":3780},"10.1016\u002Fj.cytogfr.2019.03.004",{"id":21,"text":3782,"url":21,"identifiers":3783},"Geurts, 2016, What drives osteoarthritis?-synovial versus subchondral bone pathology, Rheumatology, 56, 1461",{},{"id":21,"text":3785,"url":21,"identifiers":3786},"Ene, 2015, Synovial inflammation in patients with different stages of knee osteoarthritis, Rom. J. Morphol. Embryol., 56, 169",{},{"id":21,"text":3788,"url":21,"identifiers":3789},"Zuurmond, 2012, Synovial inflammation, immune cells and their cytokines in osteoarthritis: A review, Osteoarthr. Cartil., 20, 1484, 10.1016\u002Fj.joca.2012.08.027",{"doi":3790},"10.1016\u002Fj.joca.2012.08.027",{"id":21,"text":3792,"url":21,"identifiers":3793},"Ayral, 2005, Synovitis: A potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis - Results of a 1 year longitudinal arthroscopic study in 422 patients, Osteoarthr. Cartil., 13, 361, 10.1016\u002Fj.joca.2005.01.005",{"doi":3794},"10.1016\u002Fj.joca.2005.01.005",{"id":21,"text":3796,"url":21,"identifiers":3797},"Kapoor, 2011, Role of proinflammatory cytokines in the pathophysiology of osteoarthritis, Nat. Rev. Rheumatol., 7, 33, 10.1038\u002Fnrrheum.2010.196",{"doi":3798},"10.1038\u002Fnrrheum.2010.196",{"id":21,"text":3800,"url":21,"identifiers":3801},"Yang, 2017, Epigenetic modifications of interleukin-6 in synovial fibroblasts from osteoarthritis patients, Sci. Rep., 7, 1",{},{"id":21,"text":3803,"url":21,"identifiers":3804},"Baker, 2010, Relation of synovitis to knee pain using contrast-enhanced MRIs, Ann. Rheum. Dis., 69, 1779, 10.1136\u002Fard.2009.121426",{"doi":3805},"10.1136\u002Fard.2009.121426",{"id":21,"text":3807,"url":21,"identifiers":3808},"Roemer, 2010, Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRI, Osteoarthr. Cartil., 18, 1269, 10.1016\u002Fj.joca.2010.07.008",{"doi":3809},"10.1016\u002Fj.joca.2010.07.008",{"id":21,"text":3811,"url":21,"identifiers":3812},"Parkes, 2016, Synovial tissue volume: A treatment target in knee osteoarthritis (OA), Ann. Rheum. Dis., 75, 84, 10.1136\u002Fannrheumdis-2014-206927",{"doi":3813},"10.1136\u002Fannrheumdis-2014-206927",{"id":21,"text":3815,"url":21,"identifiers":3816},"Hunter, 2008, The Symptoms of Osteoarthritis and the Genesis of Pain, Rheum. Dis. Clin. N. Am., 34, 623, 10.1016\u002Fj.rdc.2008.05.004",{"doi":3817},"10.1016\u002Fj.rdc.2008.05.004",{"id":21,"text":3819,"url":21,"identifiers":3820},"Fusco, 2017, Degenerative Joint Diseases and Neuroinflammation, Pain. Pract., 17, 522, 10.1111\u002Fpapr.12551",{"doi":3821},"10.1111\u002Fpapr.12551",{"id":21,"text":3823,"url":21,"identifiers":3824},"Conaghan, 2005, EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 1: Prevalence of inflammation in osteoarthritis, Ann. Rheum. Dis., 64, 1703, 10.1136\u002Fard.2005.038026",{"doi":3825},"10.1136\u002Fard.2005.038026",{"id":21,"text":3827,"url":21,"identifiers":3828},"Karvonen, 1995, Synovial thickening detected by MR imaging in osteoarthritis of the knee confirmed by biopsy as synovitis, Magn. Reson. Imaging, 13, 177, 10.1016\u002F0730-725X(94)00119-N",{"doi":3829},"10.1016\u002F0730-725X(94)00119-N",{"id":21,"text":3831,"url":21,"identifiers":3832},"Loeuille, 2005, Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: Correlating magnetic resonance imaging findings with disease severity, Arthritis Rheum., 52, 3492, 10.1002\u002Fart.21373",{"doi":3833},"10.1002\u002Fart.21373",{"id":21,"text":3835,"url":21,"identifiers":3836},"Eymard, 2016, Inflammation of the infrapatellar fat pad, Jt. Bone Spine, 83, 389, 10.1016\u002Fj.jbspin.2016.02.016",{"doi":3837},"10.1016\u002Fj.jbspin.2016.02.016",{"id":21,"text":3839,"url":21,"identifiers":3840},"Gackowski, 2017, Hoffa’s Fat Pad Abnormality in the Development of Knee Osteoarthritis, Advances in Experimental Medicine and Biology, Volume 1039, 95, 10.1007\u002F5584_2017_77",{"doi":3841},"10.1007\u002F5584_2017_77",{"id":21,"text":3843,"url":21,"identifiers":3844},"Roemer, 2016, Magnetic resonance imaging of Hoffa’s fat pad and relevance for osteoarthritis research: A narrative review, Osteoarthr. Cartil., 24, 383, 10.1016\u002Fj.joca.2015.09.018",{"doi":3845},"10.1016\u002Fj.joca.2015.09.018",{"id":21,"text":3847,"url":21,"identifiers":3848},"Barboza, 2017, Profibrotic Infrapatellar Fat Pad Remodeling Without M1 Macrophage Polarization Precedes Knee Osteoarthritis in Mice With Diet-Induced Obesity, Arthritis Rheumatol., 69, 1221, 10.1002\u002Fart.40056",{"doi":3849},"10.1002\u002Fart.40056",{"id":21,"text":3851,"url":21,"identifiers":3852},"Wu, 2020, The role of macrophages in osteoarthritis and cartilage repair, Osteoarthr. Cartil., 28, 544, 10.1016\u002Fj.joca.2019.12.007",{"doi":3853},"10.1016\u002Fj.joca.2019.12.007",{"id":21,"text":3855,"url":21,"identifiers":3856},"Ushiyama, 2003, Cytokine production in the infrapatellar fat pad: Another source of cytokines in knee synovial fluids, Ann. Rheum. Dis., 62, 108, 10.1136\u002Fard.62.2.108",{"doi":3857},"10.1136\u002Fard.62.2.108",{"id":21,"text":3859,"url":21,"identifiers":3860},"Simopoulou, 2007, Differential expression of leptin and leptin’s receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism, Osteoarthr. Cartil., 15, 872, 10.1016\u002Fj.joca.2007.01.018",{"doi":3861},"10.1016\u002Fj.joca.2007.01.018",{"id":21,"text":3863,"url":21,"identifiers":3864},"Englund, 2012, Meniscus pathology, osteoarthritis and the treatment controversy, Nat. Rev. Rheumatol., 8, 412, 10.1038\u002Fnrrheum.2012.69",{"doi":3865},"10.1038\u002Fnrrheum.2012.69",{"id":21,"text":3867,"url":21,"identifiers":3868},"Hunter, 2006, The association of meniscal pathologic changes with cartilage loss in symptomatic knee osteoarthritis, Arthritis Rheum., 54, 795, 10.1002\u002Fart.21724",{"doi":3869},"10.1002\u002Fart.21724",{"id":21,"text":3871,"url":21,"identifiers":3872},"Ding, 2007, Meniscal tear as an osteoarthritis risk factor in a largely non-osteoarthritic cohort: A cross-sectional study, J. Rheumatol., 34, 776",{},{"id":21,"text":3874,"url":21,"identifiers":3875},"Crema, 2010, The association of prevalent medial meniscal pathology with cartilage loss in the medial tibiofemoral compartment over a 2-year period, Osteoarthr. Cartil., 18, 336, 10.1016\u002Fj.joca.2009.11.003",{"doi":3876},"10.1016\u002Fj.joca.2009.11.003",{"id":21,"text":3878,"url":21,"identifiers":3879},"Englund, 2010, The role of biomechanics in the initiation and progression of OA of the knee, Best Pract. Res. Clin. Rheumatol., 24, 39, 10.1016\u002Fj.berh.2009.08.008",{"doi":3880},"10.1016\u002Fj.berh.2009.08.008",{"id":21,"text":3882,"url":21,"identifiers":3883},"Roemer, 2009, The association of meniscal damage with joint effusion in persons without radiographic osteoarthritis: The Framingham and MOST osteoarthritis studies, Osteoarthr. Cartil., 17, 748, 10.1016\u002Fj.joca.2008.09.013",{"doi":3884},"10.1016\u002Fj.joca.2008.09.013",{"id":21,"text":3886,"url":21,"identifiers":3887},"Crema, 2012, Factors associated with meniscal extrusion in knees with or at risk for osteoarthritis: The multicenter osteoarthritis study, Radiology, 264, 494, 10.1148\u002Fradiol.12110986",{"doi":3888},"10.1148\u002Fradiol.12110986",{"id":21,"text":3890,"url":21,"identifiers":3891},"Stehling, 2012, Loading of the knee during 3.0 T MRI is associated with significantly increased medial meniscus extrusion in mild and moderate osteoarthritis, Eur. J. Radiol., 81, 1839, 10.1016\u002Fj.ejrad.2011.05.027",{"doi":3892},"10.1016\u002Fj.ejrad.2011.05.027",{"id":21,"text":3894,"url":21,"identifiers":3895},"Runhaar, 2017, Baseline meniscal extrusion associated with incident knee osteoarthritis after 30 months in overweight and obese women, Osteoarthr. Cartil., 25, 1299, 10.1016\u002Fj.joca.2017.03.014",{"doi":3896},"10.1016\u002Fj.joca.2017.03.014",{"id":21,"text":3898,"url":21,"identifiers":3899},"Liikavainio, 2008, Physical Function and Properties of Quadriceps Femoris Muscle in Men With Knee Osteoarthritis, Arch. Phys. Med. Rehabil., 89, 2185, 10.1016\u002Fj.apmr.2008.04.012",{"doi":3900},"10.1016\u002Fj.apmr.2008.04.012",{"id":21,"text":3902,"url":21,"identifiers":3903},"Alnahdi, 2012, Muscle impairments in patients with knee osteoarthritis, Sports Health, 4, 284, 10.1177\u002F1941738112445726",{"doi":3904},"10.1177\u002F1941738112445726",{"id":21,"text":3906,"url":21,"identifiers":3907},"Kim, J.-R., Yoo, J., and Kim, H. (2018). Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis. Int. J. Mol. Sci., 19.",{"doi":3908},"10.3390\u002Fijms19030674",{"id":21,"text":3910,"url":21,"identifiers":3911},"Roos, 2011, Muscle weakness, afferent sensory dysfunction and exercise in knee osteoarthritis, Nat. Rev. Rheumatol., 7, 57, 10.1038\u002Fnrrheum.2010.195",{"doi":3912},"10.1038\u002Fnrrheum.2010.195",{"id":21,"text":3914,"url":21,"identifiers":3915},"Raynauld, 2015, Magnetic Resonance Imaging-Assessed Vastus Medialis Muscle Fat Content and Risk for Knee Osteoarthritis Progression: Relevance From a Clinical Trial, Arthritis Care Res., 67, 1406, 10.1002\u002Facr.22590",{"doi":3916},"10.1002\u002Facr.22590",{"id":21,"text":3918,"url":21,"identifiers":3919},"Teichtahl, 2015, Vastus medialis fat infiltration—A modifiable determinant of knee cartilage loss, Osteoarthr. Cartil., 23, 2150, 10.1016\u002Fj.joca.2015.06.016",{"doi":3920},"10.1016\u002Fj.joca.2015.06.016",{"id":21,"text":3922,"url":21,"identifiers":3923},"Krishnasamy, 2018, The role of skeletal muscle in the pathophysiology and management of knee osteoarthritis, Rheumatology, 57, iv22, 10.1093\u002Frheumatology\u002Fkex515",{"doi":3924},"10.1093\u002Frheumatology\u002Fkex515",{"id":21,"text":3926,"url":21,"identifiers":3927},"Rothrauff, 2019, Anatomic ACL reconstruction reduces risk of post-traumatic osteoarthritis: A systematic review with minimum 10-year follow-up, Knee Surg. Sport Traumatol. Arthrosc., 28, 1072, 10.1007\u002Fs00167-019-05665-2",{"doi":3928},"10.1007\u002Fs00167-019-05665-2",{"id":21,"text":3930,"url":21,"identifiers":3931},"Wang, 2012, Increase in vastus medialis cross-sectional area is associated with reduced pain, cartilage loss, and joint replacement risk in knee osteoarthritis, Arthritis Rheum., 64, 3917, 10.1002\u002Fart.34681",{"doi":3932},"10.1002\u002Fart.34681",{"id":21,"text":3934,"url":21,"identifiers":3935},"Mobasheri, 2015, Biomarkers of (osteo)arthritis, Biomarkers, 20, 513, 10.3109\u002F1354750X.2016.1140930",{"doi":3936},"10.3109\u002F1354750X.2016.1140930",{"id":21,"text":3938,"url":21,"identifiers":3939},"Boehme, K.A., and Rolauffs, B. (2018). Onset and Progression of Human Osteoarthritis—Can Growth Factors, Inflammatory Cytokines, or Differential miRNA Expression Concomitantly Induce Proliferation, ECM Degradation, and Inflammation in Articular Cartilage?. Int. J. Mol. Sci., 19.",{"doi":3940},"10.3390\u002Fijms19082282",{"id":21,"text":3942,"url":21,"identifiers":3943},"Goldring, 2007, Osteoarthritis, J. Cell. Physiol., 213, 626, 10.1002\u002Fjcp.21258",{"doi":3944},"10.1002\u002Fjcp.21258",{"id":21,"text":3946,"url":21,"identifiers":3947},"Wojdasiewicz, 2014, The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis, Mediat. Inflamm., 2014, 1, 10.1155\u002F2014\u002F561459",{"doi":3948},"10.1155\u002F2014\u002F561459",{"id":21,"text":3950,"url":21,"identifiers":3951},"Mathiessen, 2017, Synovitis in osteoarthritis: Current understanding with therapeutic implications, Arthritis Res. Ther., 19, 1, 10.1186\u002Fs13075-017-1229-9",{"doi":3952},"10.1186\u002Fs13075-017-1229-9",{"id":21,"text":3954,"url":21,"identifiers":3955},"Nguyen, L., Sharma, A., Chakraborty, C., Saibaba, B., Ahn, M.-E., and Lee, S.-S. (2017). Review of Prospects of Biological Fluid Biomarkers in Osteoarthritis. Int. J. Mol. Sci., 18.",{"doi":3956},"10.3390\u002Fijms18030601",{"id":21,"text":3958,"url":21,"identifiers":3959},"Mabey, 2016, Plasma and synovial fluid inflammatory cytokine profiles in primary knee osteoarthritis, Biomarkers, 21, 639, 10.3109\u002F1354750X.2016.1171907",{"doi":3960},"10.3109\u002F1354750X.2016.1171907",{"id":21,"text":3962,"url":21,"identifiers":3963},"Zhu, 2017, Cross-sectional and longitudinal associations between serum inflammatory cytokines and knee bone marrow lesions in patients with knee osteoarthritis, Osteoarthr. Cartil., 25, 499, 10.1016\u002Fj.joca.2016.10.024",{"doi":3964},"10.1016\u002Fj.joca.2016.10.024",{"id":21,"text":3966,"url":21,"identifiers":3967},"Yang, 2016, Expression profile of cytokines and chemokines in osteoarthritis patients: Proinflammatory roles for CXCL8 and CXCL11 to chondrocytes, Int. Immunopharmacol., 40, 16, 10.1016\u002Fj.intimp.2016.08.005",{"doi":3968},"10.1016\u002Fj.intimp.2016.08.005",{"id":21,"text":3970,"url":21,"identifiers":3971},"Kassner, 2007, COMP acts as a catalyst in collagen fibrillogenesis, J. Biol. Chem., 282, 31166, 10.1074\u002Fjbc.M705735200",{"doi":3972},"10.1074\u002Fjbc.M705735200",{"id":21,"text":3974,"url":21,"identifiers":3975},"Ruan, 2018, Associations between knee structural measures, circulating inflammatory factors and MMP13 in patients with knee osteoarthritis, Osteoarthr. Cartil., 26, 1063, 10.1016\u002Fj.joca.2018.05.003",{"doi":3976},"10.1016\u002Fj.joca.2018.05.003",{"id":21,"text":3978,"url":21,"identifiers":3979},"Goldring, 2004, The Regulation of Chondrocyte Function by Proinflammatory Mediators, Clin. Orthop. Relat. Res., 427, S37, 10.1097\u002F01.blo.0000144484.69656.e4",{"doi":3980},"10.1097\u002F01.blo.0000144484.69656.e4",{"id":21,"text":3982,"url":21,"identifiers":3983},"Yang, 2019, Up-regulated HIF-2α contributes to the Osteoarthritis development through mediating the primary cilia loss, Int. Immunopharmacol., 75, 105762, 10.1016\u002Fj.intimp.2019.105762",{"doi":3984},"10.1016\u002Fj.intimp.2019.105762",{"id":21,"text":3986,"url":21,"identifiers":3987},"Alaaeddine, 2001, Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation, Arthritis Rheum., 44, 1633, 10.1002\u002F1529-0131(200107)44:7\u003C1633::AID-ART286>3.0.CO;2-Z",{"doi":3988},"10.1002\u002F1529-0131(200107)44:7\u003C1633::AID-ART286>3.0.CO;2-Z",{"id":21,"text":3990,"url":21,"identifiers":3991},"Akeson, G., and Malemud, C. (2017). A Role for Soluble IL-6 Receptor in Osteoarthritis. J. Funct. Morphol. Kinesiol., 2.",{"doi":3992},"10.3390\u002Fjfmk2030027",{"id":21,"text":3994,"url":21,"identifiers":3995},"Latourte, 2017, Systemic inhibition of IL-6\u002FStat3 signalling protects against experimental osteoarthritis, Ann. Rheum. Dis., 76, 748, 10.1136\u002Fannrheumdis-2016-209757",{"doi":3996},"10.1136\u002Fannrheumdis-2016-209757",{"id":21,"text":3998,"url":21,"identifiers":3999},"Qu, 2015, Correlation between interleukin-6 expression in articular cartilage bone and osteoarthritis, Genet. Mol. Res., 14, 14189, 10.4238\u002F2015.November.13.2",{"doi":4000},"10.4238\u002F2015.November.13.2",{"id":21,"text":4002,"url":21,"identifiers":4003},"Pearson, 2017, IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity, Sci. Rep., 7, 3451, 10.1038\u002Fs41598-017-03759-w",{"doi":4004},"10.1038\u002Fs41598-017-03759-w",{"id":21,"text":4006,"url":21,"identifiers":4007},"Saxne, 2011, The role of the cartilage matrix in osteoarthritis, Nat. Rev. Rheumatol., 7, 50, 10.1038\u002Fnrrheum.2010.198",{"doi":4008},"10.1038\u002Fnrrheum.2010.198",{"id":21,"text":4010,"url":21,"identifiers":4011},"Giordano, 2020, Serum Inflammatory Markers in Patients with Knee Osteoarthritis: A Proteomic Approach, Clin. J. Pain., 36, 229, 10.1097\u002FAJP.0000000000000804",{"doi":4012},"10.1097\u002FAJP.0000000000000804",{"id":21,"text":4014,"url":21,"identifiers":4015},"Larsson, 2009, Synovial fluid level of aggrecan ARGS fragments is a more sensitive marker of joint disease than glycosaminoglycan or aggrecan levels: A cross-sectional study, Arthritis Res. Ther., 11, R92, 10.1186\u002Far2735",{"doi":4016},"10.1186\u002Far2735",{"id":21,"text":4018,"url":21,"identifiers":4019},"Zhou, 2016, The relationship between HIF-2α and VEGF with radiographic severity in the primary osteoarthritic knee, Yonsei Med. J., 57, 735, 10.3349\u002Fymj.2016.57.3.735",{"doi":4020},"10.3349\u002Fymj.2016.57.3.735",{"id":21,"text":4022,"url":21,"identifiers":4023},"Venkatesan, 2013, rAAV-mediated overexpression of TGF-β stably restructures human osteoarthritic articular cartilage in situ, J. Transl. Med., 11, 211, 10.1186\u002F1479-5876-11-211",{"doi":4024},"10.1186\u002F1479-5876-11-211",{"id":21,"text":4026,"url":21,"identifiers":4027},"Carballo, C.B., Coelho, T.R.P., de Holanda Afonso, R.C., de O. Faria, J.C., Alves, T., Monte, S.M., Ventura Matioszek, G.M., Moura-Neto, V., and de Brito, J.M. (2018). Osteoarthritic Synovial Fluid and TGF-β1 Induce Interleukin-18 in Articular Chondrocytes. Cartilage, 194760351879614.",{"doi":4028},"10.1177\u002F1947603518796149",{"id":21,"text":4030,"url":21,"identifiers":4031},"Ruiz, 2020, TGFBI secreted by mesenchymal stromal cells ameliorates osteoarthritis and is detected in extracellular vesicles, Biomaterials, 226, 119544, 10.1016\u002Fj.biomaterials.2019.119544",{"doi":4032},"10.1016\u002Fj.biomaterials.2019.119544",{"id":21,"text":4034,"url":21,"identifiers":4035},"Zhen, 2013, Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis, Nat. Med., 19, 704, 10.1038\u002Fnm.3143",{"doi":4036},"10.1038\u002Fnm.3143",{"id":21,"text":4038,"url":21,"identifiers":4039},"Waly, 2017, IL-10 and TGF-β: Roles in chondroprotective effects of Glucosamine in experimental Osteoarthritis?, Pathophysiology, 24, 45, 10.1016\u002Fj.pathophys.2017.02.005",{"doi":4040},"10.1016\u002Fj.pathophys.2017.02.005",{"id":21,"text":4042,"url":21,"identifiers":4043},"Heard, 2014, A computational method to differentiate normal individuals, osteoarthritis and rheumatoid arthritis patients using serum biomarkers, J. R. Soc. Interface, 11, 20140428, 10.1098\u002Frsif.2014.0428",{"doi":4044},"10.1098\u002Frsif.2014.0428",{"id":21,"text":4046,"url":21,"identifiers":4047},"Kisand, 2018, New insights into the natural course of knee osteoarthritis: Early regulation of cytokines and growth factors, with emphasis on sex-dependent angiogenesis and tissue remodeling. A pilot study, Osteoarthr. Cartil., 26, 1045, 10.1016\u002Fj.joca.2018.05.009",{"doi":4048},"10.1016\u002Fj.joca.2018.05.009",{"id":21,"text":4050,"url":21,"identifiers":4051},"Leung, 2017, Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain, Osteoarthr. Cartil., 25, 1420, 10.1016\u002Fj.joca.2017.04.001",{"doi":4052},"10.1016\u002Fj.joca.2017.04.001",{"id":21,"text":4054,"url":21,"identifiers":4055},"Nees, T.A., Rosshirt, N., Zhang, J.A., Reiner, T., Sorbi, R., Tripel, E., Walker, T., Schiltenwolf, M., Hagmann, S., and Moradi, B. (2019). Synovial Cytokines Significantly Correlate with Osteoarthritis-Related Knee Pain and Disability: Inflammatory Mediators of Potential Clinical Relevance. J. Clin. Med., 8.",{"doi":4056},"10.3390\u002Fjcm8091343",{"id":21,"text":4058,"url":21,"identifiers":4059},"Grieshaber-Bouyer, R., Kämmerer, T., Rosshirt, N., Nees, T.A., Koniezke, P., Tripel, E., Schiltenwolf, M., Kirsch, J., Hagmann, S., and Moradi, B. (2019). Divergent Mononuclear Cell Participation and Cytokine Release Profiles Define Hip andKnee Osteoarthritis. J. Clin. Med., 8.",{"doi":4060},"10.3390\u002Fjcm8101631",{"id":21,"text":4062,"url":21,"identifiers":4063},"Ren, 2018, Serum and synovial fluid cytokine profiling in hip osteoarthritis: Distinct from knee osteoarthritis and correlated with pain, BMC Musculoskelet. Disord., 19, 1, 10.1186\u002Fs12891-018-1955-4",{"doi":4064},"10.1186\u002Fs12891-018-1955-4",{"id":21,"text":4066,"url":21,"identifiers":4067},"(2020, May 04). WHO | Obesity. Available online: https:\u002F\u002Fwww.who.int\u002Ftopics\u002Fobesity\u002Fen\u002F.",{},{"id":21,"text":4069,"url":21,"identifiers":4070},"2019, Obesity: Global epidemiology and pathogenesis, Nat. Rev. Endocrinol., 15, 288, 10.1038\u002Fs41574-019-0176-8",{"doi":4071},"10.1038\u002Fs41574-019-0176-8",{"id":21,"text":4073,"url":21,"identifiers":4074},"Murphy, 2008, Lifetime risk of symptomatic knee osteoarthritis, Arthritis Care Res., 59, 1207, 10.1002\u002Fart.24021",{"doi":4075},"10.1002\u002Fart.24021",{"id":21,"text":4077,"url":21,"identifiers":4078},"Powell, 2005, Obesity: A preventable risk factor for large joint osteoarthritis which may act through biomechanical factors, Br. J. Sports Med., 39, 4, 10.1136\u002Fbjsm.2004.011841",{"doi":4079},"10.1136\u002Fbjsm.2004.011841",{"id":21,"text":4081,"url":21,"identifiers":4082},"Aspden, 2011, Obesity punches above its weight in osteoarthritis, Nat. Rev. Rheumatol., 7, 65, 10.1038\u002Fnrrheum.2010.123",{"doi":4083},"10.1038\u002Fnrrheum.2010.123",{"id":21,"text":4085,"url":21,"identifiers":4086},"Sharma, 2001, The role of knee alignment in disease progression and functional decline in knee osteoarthritis, J. Am. Med. Assoc., 286, 188, 10.1001\u002Fjama.286.2.188",{"doi":4087},"10.1001\u002Fjama.286.2.188",{"id":21,"text":4089,"url":21,"identifiers":4090},"Urban, 2018, The role of fat and inflammation in the pathogenesis and management of osteoarthritis, Rheumatology, 57, iv10, 10.1093\u002Frheumatology\u002Fkex399",{"doi":4091},"10.1093\u002Frheumatology\u002Fkex399",{"id":21,"text":4093,"url":21,"identifiers":4094},"Kluzek, 2015, Adipokines as potential prognostic biomarkers in patients with acute knee injury, Biomarkers, 20, 519",{},{"id":21,"text":4096,"url":21,"identifiers":4097},"Collins, 2018, Obesity alters the in vivo mechanical response and biochemical properties of cartilage as measured by MRI, Arthritis Res. Ther., 20, 232, 10.1186\u002Fs13075-018-1727-4",{"doi":4098},"10.1186\u002Fs13075-018-1727-4",{"id":21,"text":4100,"url":21,"identifiers":4101},"Boyce, 2019, The outcomes of total knee arthroplasty in morbidly obese patients: A systematic review of the literature, Arch. Orthop. Trauma Surg., 139, 553, 10.1007\u002Fs00402-019-03127-5",{"doi":4102},"10.1007\u002Fs00402-019-03127-5",{"id":21,"text":4104,"url":21,"identifiers":4105},"Choi, 2019, Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs, Tissue Eng. Regen. Med., 16, 335, 10.1007\u002Fs13770-018-0172-4",{"doi":4106},"10.1007\u002Fs13770-018-0172-4",{"id":21,"text":4108,"url":21,"identifiers":4109},"Shen, 2017, DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism, JCI Insight, 2, e93612, 10.1172\u002Fjci.insight.93612",{"doi":4110},"10.1172\u002Fjci.insight.93612",{"id":21,"text":4112,"url":21,"identifiers":4113},"Cao, 2014, Decreased histone deacetylase 4 is associated with human osteoarthritis cartilage degeneration by releasing histone deacetylase 4 inhibition of runt-related transcription factor-2 and increasing osteoarthritis-related genes: A novel mechanism of human ost, Arthritis Res. Ther., 16, 491, 10.1186\u002Fs13075-014-0491-3",{"doi":4114},"10.1186\u002Fs13075-014-0491-3",{"id":21,"text":4116,"url":21,"identifiers":4117},"Richard, 2020, Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk, Cell, 181, 362, 10.1016\u002Fj.cell.2020.02.057",{"doi":4118},"10.1016\u002Fj.cell.2020.02.057",{"id":21,"text":4120,"url":21,"identifiers":4121},"Miyamoto, 2007, A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis, Nat. Genet., 39, 529, 10.1038\u002F2005",{"doi":4122},"10.1038\u002F2005",{"id":21,"text":4124,"url":21,"identifiers":4125},"Zengini, 2018, Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis, Nat. Genet., 50, 549, 10.1038\u002Fs41588-018-0079-y",{"doi":4126},"10.1038\u002Fs41588-018-0079-y",{"id":21,"text":4128,"url":21,"identifiers":4129},"Liu, 2018, Chromatin accessibility landscape of articular knee cartilage reveals aberrant enhancer regulation in osteoarthritis, Sci. Rep., 8, 15499, 10.1038\u002Fs41598-018-33779-z",{"doi":4130},"10.1038\u002Fs41598-018-33779-z",{"id":21,"text":4132,"url":21,"identifiers":4133},"Yu, 2015, MicroRNAs’ Involvement in Osteoarthritis and the Prospects for Treatments, Evid. Based Complement. Altern. Med., 2015, 1",{},{"id":21,"text":4135,"url":21,"identifiers":4136},"Zhang, 2017, Role of MicroRNA in Osteoarthritis, J. Arthritis, 06, 239, 10.4172\u002F2167-7921.1000239",{"doi":4137},"10.4172\u002F2167-7921.1000239",{"id":21,"text":4139,"url":21,"identifiers":4140},"Zhang, 2017, MiR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2, Cell Death Dis., 8, 1",{},{"id":21,"text":4142,"url":21,"identifiers":4143},"Ramos, 2019, TranslaTional science RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage, Ann. Rheum. Dis., 78, 270, 10.1136\u002Fannrheumdis-2018-213882",{"doi":4144},"10.1136\u002Fannrheumdis-2018-213882",{"id":21,"text":4146,"url":21,"identifiers":4147},"Miyaki, 2012, Macro view of microRNA function in osteoarthritis, Nat. Rev. Rheumatol., 8, 543, 10.1038\u002Fnrrheum.2012.128",{"doi":4148},"10.1038\u002Fnrrheum.2012.128",{"id":21,"text":4150,"url":21,"identifiers":4151},"Grigelioniene, 2019, Gain-of-function mutation of microRNA-140 in human skeletal dysplasia, Nat. Med., 25, 583, 10.1038\u002Fs41591-019-0353-2",{"doi":4152},"10.1038\u002Fs41591-019-0353-2",{"id":21,"text":4154,"url":21,"identifiers":4155},"Hu, 2019, MicroRNA-455-3p promotes TGF-β signaling and inhibits osteoarthritis development by directly targeting PAK2, Exp. Mol. Med., 51, 1, 10.1038\u002Fs12276-019-0322-3",{"doi":4156},"10.1038\u002Fs12276-019-0322-3",{"id":21,"text":4158,"url":21,"identifiers":4159},"Hu, 2017, MicroRNA-145 attenuates TNF-α-driven cartilage matrix degradation in osteoarthritis via direct suppression of MKK4, Cell Death Dis., 8, e3140, 10.1038\u002Fcddis.2017.522",{"doi":4160},"10.1038\u002Fcddis.2017.522",{"id":21,"text":4162,"url":21,"identifiers":4163},"Ragni, 2019, miR-22-5p and miR-29a-5p Are Reliable Reference Genes for Analyzing Extracellular Vesicle-Associated miRNAs in Adipose-Derived Mesenchymal Stem Cells and Are Stable under Inflammatory Priming Mimicking Osteoarthritis Condition, Stem Cell Rev. Rep., 15, 743, 10.1007\u002Fs12015-019-09899-y",{"doi":4164},"10.1007\u002Fs12015-019-09899-y",{"id":21,"text":4166,"url":21,"identifiers":4167},"Vicente, 2016, Deregulation and therapeutic potential of microRNAs in arthritic diseases, Nat. Rev. Rheumatol., 12, 211, 10.1038\u002Fnrrheum.2015.162",{"doi":4168},"10.1038\u002Fnrrheum.2015.162",{"id":21,"text":4170,"url":21,"identifiers":4171},"Huang, 2019, The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression, Nat. Commun., 10, 1",{},{"id":21,"text":4173,"url":21,"identifiers":4174},"Kang, 2019, Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development, Sci. Transl. Med., 11, eaar6659, 10.1126\u002Fscitranslmed.aar6659",{"doi":4175},"10.1126\u002Fscitranslmed.aar6659",{"id":21,"text":4177,"url":21,"identifiers":4178},"Bianchi, M., Renzini, A., Adamo, S., and Moresi, V. (2017). Coordinated Actions of MicroRNAs with other Epigenetic Factors Regulate Skeletal Muscle Development and Adaptation. Int. J. Mol. Sci., 18.",{"doi":4179},"10.3390\u002Fijms18040840",{"id":21,"text":4181,"url":21,"identifiers":4182},"Grover, 2015, Benefits of antioxidant supplements for knee osteoarthritis: Rationale and reality, Nutr. J., 15, 1, 10.1186\u002Fs12937-015-0115-z",{"doi":4183},"10.1186\u002Fs12937-015-0115-z",{"id":21,"text":4185,"url":21,"identifiers":4186},"Blanco, 2011, The role of mitochondria in osteoarthritis, Nat. Rev. Rheumatol., 7, 161, 10.1038\u002Fnrrheum.2010.213",{"doi":4187},"10.1038\u002Fnrrheum.2010.213",{"id":21,"text":4189,"url":21,"identifiers":4190},"Blanco, 2020, Mitochondrial Genetics and Epigenetics in Osteoarthritis, Front. Genet., 10, 1335, 10.3389\u002Ffgene.2019.01335",{"doi":4191},"10.3389\u002Ffgene.2019.01335",{"id":21,"text":4193,"url":21,"identifiers":4194},"Andia, 2013, Platelet-rich plasma for managing pain and inflammation in osteoarthritis, Nat. Rev. Rheumatol., 9, 721, 10.1038\u002Fnrrheum.2013.141",{"doi":4195},"10.1038\u002Fnrrheum.2013.141",{"id":21,"text":4197,"url":21,"identifiers":4198},"Andia, 2019, Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: Current consensus, clinical implications and perspectives, Muscle Ligaments Tendons J., 4, 3, 10.32098\u002Fmltj.01.2014.02",{"doi":4199},"10.32098\u002Fmltj.01.2014.02",{"id":21,"text":4201,"url":21,"identifiers":4202},"Wu, 2020, Platelet-rich plasma versus hyaluronic acid in knee osteoarthritis: A meta-analysis with the consistent ratio of injection, J. Orthop. Surg., 28, 1, 10.1177\u002F2309499019887660",{"doi":4203},"10.1177\u002F2309499019887660",{"id":21,"text":4205,"url":21,"identifiers":4206},"Magalhaes, 2019, Platelet-rich plasma in osteoarthritis treatment: Review of current evidence, Ther. Adv. Chronic Dis., 10, 1",{},{"id":21,"text":4208,"url":21,"identifiers":4209},"Sundaram, 2019, Are Subchondral Intraosseous Injections Effective and Safe for the Treatment of Knee Osteoarthritis? A Systematic Review, J. Knee Surg., 32, 1046, 10.1055\u002Fs-0039-1677792",{"doi":4210},"10.1055\u002Fs-0039-1677792",{"id":21,"text":4212,"url":21,"identifiers":4213},"Delgado, 2019, Treating Severe Knee Osteoarthritis with Combination of Intra-Osseous and Intra-Articular Infiltrations of Platelet-Rich Plasma: An Observational Study, Cartilage, 10, 245, 10.1177\u002F1947603518756462",{"doi":4214},"10.1177\u002F1947603518756462",{"id":21,"text":4216,"url":21,"identifiers":4217},"Ponchel, 2015, Changes in peripheral blood immune cell composition in osteoarthritis, Osteoarthr. Cartil., 23, 1870, 10.1016\u002Fj.joca.2015.06.018",{"doi":4218},"10.1016\u002Fj.joca.2015.06.018",{"id":21,"text":4220,"url":21,"identifiers":4221},"Daghestani, 2015, Inflammatory biomarkers in osteoarthritis, Osteoarthr. Cartil., 23, 1890, 10.1016\u002Fj.joca.2015.02.009",{"doi":4222},"10.1016\u002Fj.joca.2015.02.009",{"id":21,"text":4224,"url":21,"identifiers":4225},"Caplan, 2019, Medicinal signalling cells: They work, so use them, Nature, 566, 39, 10.1038\u002Fd41586-019-00490-6",{"doi":4226},"10.1038\u002Fd41586-019-00490-6",{"id":21,"text":4228,"url":21,"identifiers":4229},"Caplan, 2015, Body Management: Mesenchymal Stem Cells Control the Internal Regenerator, Stem Cells Transl. Med., 4, 695, 10.5966\u002Fsctm.2014-0291",{"doi":4230},"10.5966\u002Fsctm.2014-0291",{"id":21,"text":4232,"url":21,"identifiers":4233},"Caplan, 2010, What’s in a Name?, Tissue Eng. Part A, 16, 2415, 10.1089\u002Ften.tea.2010.0216",{"doi":4234},"10.1089\u002Ften.tea.2010.0216",{"id":21,"text":4236,"url":21,"identifiers":4237},"McGonagle, 2017, Native joint-resident mesenchymal stem cells for cartilage repair in osteoarthritis, Nat. Rev. Rheumatol., 13, 719, 10.1038\u002Fnrrheum.2017.182",{"doi":4238},"10.1038\u002Fnrrheum.2017.182",{"id":21,"text":4240,"url":21,"identifiers":4241},"Saris, 2015, Direct cell-cell contact with chondrocytes is a key mechanism in multipotent mesenchymal stromal cell-mediated chondrogenesis, Tissue Eng. Part A, 21, 2536, 10.1089\u002Ften.tea.2014.0673",{"doi":4242},"10.1089\u002Ften.tea.2014.0673",{"id":21,"text":4244,"url":21,"identifiers":4245},"Mancuso, 2019, Mesenchymal Stem Cell Therapy for Osteoarthritis: The Critical Role of the Cell Secretome, Front. Bioeng. Biotechnol., 7, 9, 10.3389\u002Ffbioe.2019.00009",{"doi":4246},"10.3389\u002Ffbioe.2019.00009",{"id":21,"text":4248,"url":21,"identifiers":4249},"Pittenger, 2019, Mesenchymal stem cell perspective: Cell biology to clinical progress, Npj Regen. Med., 4, 22, 10.1038\u002Fs41536-019-0083-6",{"doi":4250},"10.1038\u002Fs41536-019-0083-6",{"id":21,"text":4252,"url":21,"identifiers":4253},"Ren, 2008, Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide, Cell Stem Cell, 2, 141, 10.1016\u002Fj.stem.2007.11.014",{"doi":4254},"10.1016\u002Fj.stem.2007.11.014",{"id":21,"text":4256,"url":21,"identifiers":4257},"Wang, 2017, Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix, Stem Cell Res. Ther., 8, 189, 10.1186\u002Fs13287-017-0632-0",{"doi":4258},"10.1186\u002Fs13287-017-0632-0",{"id":21,"text":4260,"url":21,"identifiers":4261},"Kim, 2019, Intra-articular injection of mesenchymal stem cells for clinical outcomes and cartilage repair in osteoarthritis of the knee: A meta-analysis of randomized controlled trials, Arch. Orthop. Trauma Surg., 139, 971, 10.1007\u002Fs00402-019-03140-8",{"doi":4262},"10.1007\u002Fs00402-019-03140-8",{"id":21,"text":4264,"url":21,"identifiers":4265},"Caplan, 2011, The MSC: An Injury Drugstore, Cell Stem Cell, 9, 11, 10.1016\u002Fj.stem.2011.06.008",{"doi":4266},"10.1016\u002Fj.stem.2011.06.008",{"id":21,"text":4268,"url":21,"identifiers":4269},"Hass, 2011, Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC, Cell Commun. Signal., 9, 12, 10.1186\u002F1478-811X-9-12",{"doi":4270},"10.1186\u002F1478-811X-9-12",{"id":21,"text":4272,"url":21,"identifiers":4273},"Hassan, 2004, Adult bone-marrow stem cells and their potential in medicine, J. R. Soc. Med., 97, 465, 10.1177\u002F0141076809701003",{"doi":4274},"10.1177\u002F0141076809701003",{"id":21,"text":4276,"url":21,"identifiers":4277},"Chahal, 2019, Bone Marrow Mesenchymal Stromal Cell Treatment in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation, Stem Cells Transl. Med., 8, 746, 10.1002\u002Fsctm.18-0183",{"doi":4278},"10.1002\u002Fsctm.18-0183",{"id":21,"text":4280,"url":21,"identifiers":4281},"Gupta, 2016, Efficacy and safety of adult human bone marrow-derived, cultured, pooled, allogeneic mesenchymal stromal cells (Stempeucel®): Preclinical and clinical trial in osteoarthritis of the knee joint, Arthritis Res. Ther., 18, 301, 10.1186\u002Fs13075-016-1195-7",{"doi":4282},"10.1186\u002Fs13075-016-1195-7",{"id":21,"text":4284,"url":21,"identifiers":4285},"Vega, 2015, Treatment of knee osteoarthritis with allogeneic bone marrow mesenchymal stem cells: A randomized controlled trial, Transplantation, 99, 1681, 10.1097\u002FTP.0000000000000678",{"doi":4286},"10.1097\u002FTP.0000000000000678",{"id":21,"text":4288,"url":21,"identifiers":4289},"Awad, 2019, Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment, Stem Cells Int., 2019, 1, 10.1155\u002F2019\u002F3826054",{"doi":4290},"10.1155\u002F2019\u002F3826054",{"id":21,"text":4292,"url":21,"identifiers":4293},"Maumus, 2018, Cellules souches mésenchymateuses et médecine régénératrice, Méd. Sci., 34, 1092",{},{"id":21,"text":4295,"url":21,"identifiers":4296},"Bodiroga-Vukobrat, N., Rukavina, D., Pavelić, K., and Sander, G.G. (2019). The Future of Cartilage Repair. Personalized Medicine in Healthcare Systems: Legal, Medical and Economic Implications, Springer International Publishing.",{"doi":4297},"10.1007\u002F978-3-030-16465-2",{"id":21,"text":4299,"url":21,"identifiers":4300},"Hudetz, D., Borić, I., Rod, E., Jeleč, Ž., Radić, A., Vrdoljak, T., Skelin, A., Lauc, G., Trbojević-Akmačić, I., and Plečko, M. (2017). The Effect of Intra-articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis. Genes, 8.",{"doi":4301},"10.3390\u002Fgenes8100270",{"id":21,"text":4303,"url":21,"identifiers":4304},"Hudetz, 2019, Early results of intra-articular micro-fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: A prospective study, Croat. Med. J., 60, 227, 10.3325\u002Fcmj.2019.60.227",{"doi":4305},"10.3325\u002Fcmj.2019.60.227",{"id":21,"text":4307,"url":21,"identifiers":4308},"Polancec, D., Zenic, L., Hudetz, D., Boric, I., Jelec, Z., Rod, E., Vrdoljak, T., Skelin, A., Plecko, M., and Turkalj, M. (2019). Immunophenotyping of a Stromal Vascular Fraction from Microfragmented Lipoaspirate Used in Osteoarthritis Cartilage Treatment and Its Lipoaspirate Counterpart. Genes, 10.",{"doi":4309},"10.3390\u002Fgenes10060474",{"id":21,"text":4311,"url":21,"identifiers":4312},"Borić, I., Hudetz, D., Rod, E., Jeleč, Ž., Vrdoljak, T., Skelin, A., Polašek, O., Plečko, M., Trbojević-Akmačić, I., and Lauc, G. (2019). A 24-Month Follow-Up Study of the Effect of Intra-Articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis. Genes, 10.",{"doi":4313},"10.3390\u002Fgenes10121051",{"id":21,"text":4315,"url":21,"identifiers":4316},"Russo, 2018, Autologous micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis: An update at 3 year follow-up, J. Exp. Orthop., 5, 52, 10.1186\u002Fs40634-018-0169-x",{"doi":4317},"10.1186\u002Fs40634-018-0169-x",{"id":21,"text":4319,"url":21,"identifiers":4320},"Mautner, 2019, Functional Outcomes Following Microfragmented Adipose Tissue Versus Bone Marrow Aspirate Concentrate Injections for Symptomatic Knee Osteoarthritis, Stem Cells Transl. Med., 8, 1149, 10.1002\u002Fsctm.18-0285",{"doi":4321},"10.1002\u002Fsctm.18-0285",{"id":21,"text":4323,"url":21,"identifiers":4324},"Russo, 2017, Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis, J. Exp. Orthop., 4, 33, 10.1186\u002Fs40634-017-0108-2",{"doi":4325},"10.1186\u002Fs40634-017-0108-2",{"id":21,"text":4327,"url":21,"identifiers":4328},"Peretti, 2018, Evaluation of the use of autologous micro-fragmented adipose tissue in the treatment of knee osteoarthritis: Preliminary results of a randomized controlled trial, J. Biol. Regul. Homeost. Agents, 32, 193",{},{"id":21,"text":4330,"url":21,"identifiers":4331},"Freitag, 2019, Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: A randomized controlled trial, Regen. Med., 14, 213, 10.2217\u002Frme-2018-0161",{"doi":4332},"10.2217\u002Frme-2018-0161",{"id":21,"text":4334,"url":21,"identifiers":4335},"Yun, 2016, Adipose-derived mesenchymal stem cells and platelet-rich plasma synergistically ameliorate the surgical-induced osteoarthritis in Beagle dogs, J. Orthop. Surg. Res., 11, 9, 10.1186\u002Fs13018-016-0342-9",{"doi":4336},"10.1186\u002Fs13018-016-0342-9",{"id":21,"text":4338,"url":21,"identifiers":4339},"Pak, J., Chang, J.-J., Lee, J.H., and Lee, S.H. (2013). Safety reporting on implantation of autologous adipose tissue-derived stem cells with platelet-rich plasma into human articular joints. BMC Musculoskelet. Disord., 14.",{"doi":4340},"10.1186\u002F1471-2474-14-337",{"id":21,"text":4342,"url":21,"identifiers":4343},"Jayaram, 2019, Bone Marrow-Derived and Adipose-Derived Mesenchymal Stem Cell Therapy in Primary Knee Osteoarthritis: A Narrative Review, PM&R, 11, 177, 10.1016\u002Fj.pmrj.2018.06.019",{"doi":4344},"10.1016\u002Fj.pmrj.2018.06.019",{"id":21,"text":4346,"url":21,"identifiers":4347},"Shariatzadeh, 2019, The efficacy of different sources of mesenchymal stem cells for the treatment of knee osteoarthritis, Cell Tissue Res., 378, 399, 10.1007\u002Fs00441-019-03069-9",{"doi":4348},"10.1007\u002Fs00441-019-03069-9",{"id":21,"text":4350,"url":21,"identifiers":4351},"Wu, 2020, Extracellular vesicles: Potential role in osteoarthritis regenerative medicine, J. Orthop. Transl., 21, 73",{},{"id":21,"text":4353,"url":21,"identifiers":4354},"Lener, 2015, Applying extracellular vesicles based therapeutics in clinical trials—An ISEV position paper, J. Extracell. Vesicles, 4, 30087, 10.3402\u002Fjev.v4.30087",{"doi":4355},"10.3402\u002Fjev.v4.30087",{"id":21,"text":4357,"url":21,"identifiers":4358},"Morrison, 2017, Mesenchymal Stromal Cells Modulate Macrophages in Clinically Relevant Lung Injury Models by Extracellular Vesicle Mitochondrial Transfer, Am. J. Respir. Crit. Care Med., 196, 1275, 10.1164\u002Frccm.201701-0170OC",{"doi":4359},"10.1164\u002Frccm.201701-0170OC",{"id":21,"text":4361,"url":21,"identifiers":4362},"Tan, 2020, Mesenchymal Stem Cell Exosomes for Cartilage Regeneration: A Systematic Review of Preclinical In Vivo Studies, Tissue Eng. Part B Rev., 2019, 0326",{},{"id":21,"text":4364,"url":21,"identifiers":4365},"Sun, 2008, Transforming Growth Factor-Beta-Regulated miR-24 Promotes Skeletal Muscle Differentiation, Nucleic Acids Res., 36, 2690, 10.1093\u002Fnar\u002Fgkn032",{"doi":4366},"10.1093\u002Fnar\u002Fgkn032",{"id":21,"text":4368,"url":21,"identifiers":4369},"Fleury, 2014, Extracellular Vesicles as Therapeutic Tools in Cardiovascular Diseases, Front. Immunol., 5, 370, 10.3389\u002Ffimmu.2014.00370",{"doi":4370},"10.3389\u002Ffimmu.2014.00370",{"id":21,"text":4372,"url":21,"identifiers":4373},"Goldie, 2014, Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons, Nucleic Acids Res., 42, 9195, 10.1093\u002Fnar\u002Fgku594",{"doi":4374},"10.1093\u002Fnar\u002Fgku594",{"id":21,"text":4376,"url":21,"identifiers":4377},"Allan, 2016, Identification of clinical phenotypes in knee osteoarthritis: A systematic review of the literature, BMC Musculoskelet. Disord., 17, 1",{},{"id":21,"text":4379,"url":21,"identifiers":4380},"Dell’Isola, A., Steultjens, M., Dell’Isola, A., Steultjens, M., Isola, A.D., and Steultjens, M. (2018). Classification of patients with knee osteoarthritis in clinical phenotypes: Data from the osteoarthritis initiative. PLoS ONE, 13.",{"doi":4381},"10.1371\u002Fjournal.pone.0191045",{"id":21,"text":4383,"url":21,"identifiers":4384},"Kubassova, 2019, Osteoarthritis phenotypes and novel therapeutic targets, Biochem. Pharmacol., 165, 41, 10.1016\u002Fj.bcp.2019.02.037",{"doi":4385},"10.1016\u002Fj.bcp.2019.02.037",{"id":21,"text":4387,"url":21,"identifiers":4388},"Chen, 2019, Fibroblast growth factors: Potential novel targets for regenerative therapy of osteoarthritis, Chin. J. Physiol., 62, 2, 10.4103\u002FCJP.CJP_11_19",{"doi":4389},"10.4103\u002FCJP.CJP_11_19",{"id":21,"text":4391,"url":21,"identifiers":4392},"Meloni, 2019, Recombinant human FGF18 preserves depth-dependent mechanical inhomogeneity in articular cartilage, Eur. Cells Mater., 38, 23, 10.22203\u002FeCM.v038a03",{"doi":4393},"10.22203\u002FeCM.v038a03",{"id":21,"text":4395,"url":21,"identifiers":4396},"Eckstein, 2020, Intra-articular sprifermin reduces cartilage loss in addition to increasing cartilage gain independent of location in the femorotibial joint: Post-hoc analysis of a randomised, placebo-controlled phase II clinical trial, Ann. Rheum. Dis., 79, 525, 10.1136\u002Fannrheumdis-2019-216453",{"doi":4397},"10.1136\u002Fannrheumdis-2019-216453",{"id":21,"text":4399,"url":21,"identifiers":4400},"Hochberg, 2019, Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis, JAMA, 322, 1360, 10.1001\u002Fjama.2019.14735",{"doi":4401},"10.1001\u002Fjama.2019.14735",{"id":21,"text":4403,"url":21,"identifiers":4404},"Gigout, 2017, Sprifermin (rhFGF18) enables proliferation of chondrocytes producing a hyaline cartilage matrix, Osteoarthr. Cartil., 25, 1858, 10.1016\u002Fj.joca.2017.08.004",{"doi":4405},"10.1016\u002Fj.joca.2017.08.004",{"id":21,"text":4407,"url":21,"identifiers":4408},"Gregori, 2018, Association of Pharmacological Treatments With Long-term Pain Control in Patients With Knee Osteoarthritis, JAMA, 320, 2564, 10.1001\u002Fjama.2018.19319",{"doi":4409},"10.1001\u002Fjama.2018.19319",{"id":21,"text":4411,"url":21,"identifiers":4412},"Scharf, 2006, Bone morphogenetic protein 7 (bmp-7) stimulates Proteoglycan synthesis in human osteoarthritic chondrocytes in vitro, Biomed. Pharmacother., 60, 639, 10.1016\u002Fj.biopha.2006.09.001",{"doi":4413},"10.1016\u002Fj.biopha.2006.09.001",{"id":21,"text":4415,"url":21,"identifiers":4416},"(2009). Bone morphogenetic protein 7 inhibits cartilage degradation in a rabbit model of osteoarthritis. Nat. Clin. Pract. Rheumatol., 5, 4.",{"doi":4417},"10.1038\u002Fncprheum0955",{"id":21,"text":4419,"url":21,"identifiers":4420},"Hayashi, 2008, Weekly intra-articular injections of bone morphogenetic protein-7 inhibits osteoarthritis progression, Arthritis Res. Ther., 10, R118, 10.1186\u002Far2521",{"doi":4421},"10.1186\u002Far2521",{"id":21,"text":4423,"url":21,"identifiers":4424},"Hunter, D.J., Pike, M.C., Jonas, B.L., Kissin, E., Krop, J., and McAlindon, T. (2010). Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis. BMC Musculoskelet. Disord., 11.",{"doi":4425},"10.1186\u002F1471-2474-11-232",{"id":21,"text":4427,"url":21,"identifiers":4428},"Mimpen, 2019, Chondroprotective Factors in Osteoarthritis: A Joint Affair, Curr. Rheumatol. Rep., 21, 1, 10.1007\u002Fs11926-019-0840-y",{"doi":4429},"10.1007\u002Fs11926-019-0840-y",{"id":21,"text":4431,"url":21,"identifiers":4432},"Oo, 2018, Disease-modifying drugs in osteoarthritis: Current understanding and future therapeutics, Expert Opin. Emerg. Drugs, 23, 331, 10.1080\u002F14728214.2018.1547706",{"doi":4433},"10.1080\u002F14728214.2018.1547706",{"id":21,"text":4435,"url":21,"identifiers":4436},"Shepard, 2017, Developments in therapy with monoclonal antibodies and related proteins, Clin. Med. J. R. Coll. Physicians Lond., 17, 220",{},{"id":21,"text":4438,"url":21,"identifiers":4439},"Das, 2018, Blockade of vascular endothelial growth factor receptor-1 (Flt-1), reveals a novel analgesic for osteoarthritis-induced joint pain, Gene Rep., 11, 94, 10.1016\u002Fj.genrep.2018.03.008",{"doi":4440},"10.1016\u002Fj.genrep.2018.03.008",{"id":21,"text":4442,"url":21,"identifiers":4443},"Kan, S.-L., Li, Y., Ning, G.-Z., Yuan, Z.-F., Chen, L.-X., Bi, M.-C., Sun, J.-C., and Feng, S.-Q. (2016). Tanezumab for Patients with Osteoarthritis of the Knee: A Meta-Analysis. PLoS ONE, 11.",{"doi":4444},"10.1371\u002Fjournal.pone.0157105",{"id":21,"text":4446,"url":21,"identifiers":4447},"Schnitzer, 2019, Effect of Tanezumab on Joint Pain, Physical Function, and Patient Global Assessment of Osteoarthritis among Patients with Osteoarthritis of the Hip or Knee: A Randomized Clinical Trial, JAMA J. Am. Med. Assoc., 322, 37, 10.1001\u002Fjama.2019.8044",{"doi":4448},"10.1001\u002Fjama.2019.8044",{"id":21,"text":4450,"url":21,"identifiers":4451},"Tiseo, 2014, Fasinumab (REGN475), an antibody against nerve growth factor for the treatment of pain: Results from a double-blind, placebo-controlled exploratory study in osteoarthritis of the knee, Pain, 155, 1245, 10.1016\u002Fj.pain.2014.03.018",{"doi":4452},"10.1016\u002Fj.pain.2014.03.018",{"id":21,"text":4454,"url":21,"identifiers":4455},"Gow, 2015, Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects, Arthritis Res. Ther., 17, 282, 10.1186\u002Fs13075-015-0797-9",{"doi":4456},"10.1186\u002Fs13075-015-0797-9",{"id":21,"text":4458,"url":21,"identifiers":4459},"Miller, 2016, Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis, Osteoarthr. Cartil., 24, 299, 10.1016\u002Fj.joca.2015.09.005",{"doi":4460},"10.1016\u002Fj.joca.2015.09.005",{"id":21,"text":4462,"url":21,"identifiers":4463},"Nixon, 2018, Disease-Modifying Osteoarthritis Treatment With Interleukin-1 Receptor Antagonist Gene Therapy in Small and Large Animal Models, Arthritis Rheumatol., 70, 1757, 10.1002\u002Fart.40668",{"doi":4464},"10.1002\u002Fart.40668",{"id":21,"text":4466,"url":21,"identifiers":4467},"Gersbach, 2019, The next generation of CRISPR–Cas technologies and applications, Nat. Rev. Mol. Cell Biol., 20, 490, 10.1038\u002Fs41580-019-0131-5",{"doi":4468},"10.1038\u002Fs41580-019-0131-5",{"id":21,"text":4470,"url":21,"identifiers":4471},"Zhao, 2019, Exploration of CRISPR\u002FCas9-based gene editing as therapy for osteoarthritis, Ann. Rheum. Dis., 78, 676, 10.1136\u002Fannrheumdis-2018-214724",{"doi":4472},"10.1136\u002Fannrheumdis-2018-214724",{"id":4474,"createTime":4475,"updateTime":4475,"relativeEntities":4476,"slug":4477,"properties":4478,"entityType":964,"verifyStatus":121,"verifyTime":4475,"verifyNote":1071,"languages":4493,"translateLanguages":21,"viewCount":22,"primaryUrl":4494,"fullTextUrl":21,"authors":4495,"publicationType":991,"publisherRelationship":4557,"citationCount":4611,"citationInfo":4612,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":4614,"openAccess":21,"references":4615,"isForceReanalyzing":1050},"62b2fcfe-52ee-4a4c-b97d-c4443d79cc29","2024-10-10T21:22:01.332+00:00",[],"Genetics-of-Charcot-Marie-Tooth-CMT-Disease-within-the-Frame-of-the-Human-Genome-Project-Success",{"mag":4479,"pmc":4481,"openalex":4483,"abstract":4485,"title":4487,"pm":4489,"doi":4491},{"VOID":4480},"2032806627",{"VOID":4482},"3978509",{"VOID":4484},"W2032806627",{"EN":4486},"\u003Cjats:p>Charcot-Marie-Tooth (CMT) neuropathies comprise a group of monogenic disorders affecting the peripheral nervous system. CMT is characterized by a clinically and genetically heterogeneous group of neuropathies, involving all types of Mendelian inheritance patterns. Over 1,000 different mutations have been discovered in 80  disease-associated genes. Genetic research of CMT has pioneered the discovery of genomic disorders and aided in understanding the effects of copy number variation and the mechanisms of genomic rearrangements. CMT genetic study also unraveled common pathomechanisms for peripheral nerve degeneration, elucidated gene networks, and initiated the development of therapeutic approaches. The reference genome, which became available thanks to the Human Genome Project, and the development of next generation sequencing tools, considerably accelerated gene and mutation discoveries. In fact, the first clinical whole genome sequence was reported in a patient with CMT. Here we review the history of CMT gene discoveries, starting with technologies from the early days in human genetics through the high-throughput application of modern DNA analyses. We highlight the most relevant examples of CMT genes and mutation mechanisms, some of which provide promising treatment strategies. Finally, we propose future initiatives to accelerate diagnosis of CMT patients through new ways of sharing large datasets and genetic variants, and at ever diminishing costs.\u003C\u002Fjats:p>",{"EN":4488},"Genetics of Charcot-Marie-Tooth (CMT) Disease within the Frame of the Human Genome Project Success",{"VOID":4490},"24705285",{"VOID":4492},"10.3390\u002Fgenes5010013",[125],"https:\u002F\u002Fwww.mdpi.com\u002F2073-4425\u002F5\u002F1\u002F13",[4496,4523,4540],{"id":4497,"sortIndex":22,"researcher":21,"roles":4498,"affiliations":4499,"properties":4516,"displayName":4520,"givenName":21,"familyName":21},"20c7d43c-8596-4d95-981c-436b5fee6ec5",[],[4500,4508],{"id":4501,"sortIndex":22,"affiliation":4502,"properties":21},"f490be29-9c14-400b-84aa-da01ff6924de",{"id":4501,"createTime":21,"updateTime":21,"relativeEntities":4503,"slug":21,"properties":4504,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":4507,"statistic":21},[],{"title":4505},{"EN":4506},"Neurogenetics Group, Institute Born Bunge, University of Antwerp, Antwerpen B2610, Belgium",[],{"id":4509,"sortIndex":93,"affiliation":4510,"properties":21},"ec2cdd49-e53f-4ef6-b004-81cd5c4ef8b5",{"id":4509,"createTime":21,"updateTime":21,"relativeEntities":4511,"slug":21,"properties":4512,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":4515,"statistic":21},[],{"title":4513},{"EN":4514},"Peripheral Neuropathy Group, Molecular Genetics Department, VIB, University of Antwerp, Universiteitsplein 1, Antwerpen B2610, Belgium",[],{"orcid":4517,"title":4519,"openalex":4521},{"VOID":4518},"https:\u002F\u002Forcid.org\u002F0000-0002-2162-0933",{"EN":4520},"Vincent Timmerman",{"VOID":4522},"A5000437761",{"id":4524,"sortIndex":93,"researcher":21,"roles":4525,"affiliations":4526,"properties":4535,"displayName":4537,"givenName":21,"familyName":21},"00d2b060-ad3b-4375-9d91-be2f2d0e8e38",[],[4527],{"id":4528,"sortIndex":22,"affiliation":4529,"properties":21},"b00150d4-01c0-46bf-b412-41722748293b",{"id":4528,"createTime":21,"updateTime":21,"relativeEntities":4530,"slug":21,"properties":4531,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":4534,"statistic":21},[],{"title":4532},{"EN":4533},"Department of Human Genetics, Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Biomedical Research Building, Room 523, LC: M-860, 1501 NW 10 Ave., Miami, FL 33136, USA",[],{"title":4536,"openalex":4538},{"EN":4537},"Alleene V. 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Med., 6, 97",{},{"id":21,"text":4620,"url":21,"identifiers":4621},"Tooth, H.H. (1886). The Peroneal Type of Progressive Muscular Atrophy, H.K. Lewis and Co.",{},{"id":21,"text":4623,"url":21,"identifiers":4624},"Dyck, P.J., Thomas, P.K., and Lambert, E.H. (1975). Peripheral Neuropathy, W.B. Saunders Company. [1st ed.].",{},{"id":21,"text":4626,"url":21,"identifiers":4627},"Dyck, P.J., Thomas, P.K., Griffin, J.W., Low, P.A., and Poduslo, J.F. (2005). Peripheral Neuropathy, WB Saunders. [4th ed.].",{},{"id":21,"text":4629,"url":21,"identifiers":4630},"Harding, 1980, The clinical features of hereditary motor and sensory neuropathy types I and II, Brain, 103, 259, 10.1093\u002Fbrain\u002F103.2.259",{"doi":4631},"10.1093\u002Fbrain\u002F103.2.259",{"id":21,"text":4633,"url":21,"identifiers":4634},"Timmerman, 2013, Overlapping molecular pathological themes link Charcot-Marie-Tooth neuropathies and hereditary spastic paraplegias, Exp. Neurol., 246, 14, 10.1016\u002Fj.expneurol.2012.01.010",{"doi":4635},"10.1016\u002Fj.expneurol.2012.01.010",{"id":21,"text":4637,"url":21,"identifiers":4638},"Reilly, 2011, Charcot-Marie-Tooth disease, J. Peripher. Nerv. Syst., 16, 1, 10.1111\u002Fj.1529-8027.2011.00324.x",{"doi":4639},"10.1111\u002Fj.1529-8027.2011.00324.x",{"id":21,"text":4641,"url":21,"identifiers":4642},"Saporta, 2013, Inherited peripheral neuropathies, Neurol. Clin., 31, 597, 10.1016\u002Fj.ncl.2013.01.009",{"doi":4643},"10.1016\u002Fj.ncl.2013.01.009",{"id":21,"text":4645,"url":21,"identifiers":4646},"Bird, 1982, Evidence for linkage of Charcot-Marie-Tooth neuropathy to the Duffy locus on chromosome 1, Am. J. Hum. Genet., 34, 388",{},{"id":21,"text":4648,"url":21,"identifiers":4649},"Venter, 2001, The sequence of the human genome, Science, 291, 1304, 10.1126\u002Fscience.1058040",{"doi":4650},"10.1126\u002Fscience.1058040",{"id":21,"text":4652,"url":21,"identifiers":4653},"Lander, 2001, Initial sequencing and analysis of the human genome, Nature, 409, 860, 10.1038\u002F35057062",{"doi":4654},"10.1038\u002F35057062",{"id":21,"text":4656,"url":21,"identifiers":4657},"Ng, 2009, Targeted capture and massively parallel sequencing of 12 human exomes, Nature, 461, 272, 10.1038\u002Fnature08250",{"doi":4658},"10.1038\u002Fnature08250",{"id":21,"text":4660,"url":21,"identifiers":4661},"Ng, 2010, Exome sequencing identifies the cause of a mendelian disorder, Nat. Genet., 42, 30, 10.1038\u002Fng.499",{"doi":4662},"10.1038\u002Fng.499",{"id":21,"text":4664,"url":21,"identifiers":4665},"Pitceathly, 2012, Genetic dysfunction of MT-ATP6 causes axonal Charcot-Marie-Tooth disease, Neurology, 79, 1145, 10.1212\u002FWNL.0b013e3182698d8d",{"doi":4666},"10.1212\u002FWNL.0b013e3182698d8d",{"id":21,"text":4668,"url":21,"identifiers":4669},"Suter, 2003, Disease mechanisms in inherited neuropathies, Nat. Rev. Neurosci., 4, 714, 10.1038\u002Fnrn1196",{"doi":4670},"10.1038\u002Fnrn1196",{"id":21,"text":4672,"url":21,"identifiers":4673},"Ingenuity Systems. Available online:http:\u002F\u002Fwww.ingenuity.com\u002F.",{},{"id":21,"text":4675,"url":21,"identifiers":4676},"Online Mendelian Inheritance in Man Database (OMIM). Available online:http:\u002F\u002Fncbi.nlm.nih.gov\u002Fomim\u002F.",{},{"id":21,"text":4678,"url":21,"identifiers":4679},"Inherited Peripheral Neuropathy Mutation Database (IPNMDB). Available online:http:\u002F\u002Fmolgen.vib-ua.be\u002FCMTMutations\u002F.",{},{"id":21,"text":4681,"url":21,"identifiers":4682},"Leiden Open (Source) Variation Database (LOVD). Available online:http:\u002F\u002Flovd.nl\u002F.",{},{"id":21,"text":4684,"url":21,"identifiers":4685},"Bird, 1999, Historical perspective of defining Charcot-Marie-Tooth type 1B, Ann. N. Y. Acad. Sci., 883, 6, 10.1111\u002Fj.1749-6632.1999.tb08561.x",{"doi":4686},"10.1111\u002Fj.1749-6632.1999.tb08561.x",{"id":21,"text":4688,"url":21,"identifiers":4689},"Vance, 1989, Linkage of Charcot-Marie-Tooth neuropathy type 1a to chromosome 17, Exp. Neurol., 104, 186, 10.1016\u002FS0014-4886(89)80013-5",{"doi":4690},"10.1016\u002FS0014-4886(89)80013-5",{"id":21,"text":4692,"url":21,"identifiers":4693},"Raeymaekers, 1989, Localization of the mutation in an extended family with Charcot- Marie-Tooth neuropathy (HMSN I), Am. J. Hum. Genet., 45, 953",{},{"id":21,"text":4695,"url":21,"identifiers":4696},"Harding, 1990, Linkage of hereditary motor and sensory neuropathy type I to the pericentromeric region of chromosome 17, Am. J. Hum. Genet., 46, 92",{},{"id":21,"text":4698,"url":21,"identifiers":4699},"Hayasaka, 1993, Charcot-Marie-Tooth neuropathy type 1B is associated with mutations of the myelin P0 gene, Nat. Genet., 5, 31, 10.1038\u002Fng0993-31",{"doi":4700},"10.1038\u002Fng0993-31",{"id":21,"text":4702,"url":21,"identifiers":4703},"Lacroix, 1999, The Roussy-Levy family: From the original description to the gene, Ann. Neurol., 46, 770, 10.1002\u002F1531-8249(199911)46:5\u003C770::AID-ANA13>3.0.CO;2-U",{"doi":4704},"10.1002\u002F1531-8249(199911)46:5\u003C770::AID-ANA13>3.0.CO;2-U",{"id":21,"text":4706,"url":21,"identifiers":4707},"Pareyson, 1999, Heterozygous null mutation in the P0 gene associated with mild Charcot-Marie-Tooth disease, Ann. N. Y. Acad. Sci., 883, 477, 10.1111\u002Fj.1749-6632.1999.tb08615.x",{"doi":4708},"10.1111\u002Fj.1749-6632.1999.tb08615.x",{"id":21,"text":4710,"url":21,"identifiers":4711},"Warner, 1996, Clinical phenotypes of different MPZ (P0) mutations may include Charcot-Marie-Tooth 1B, Dejerine-Sottas and congenital hypomyelination, Neuron, 17, 451, 10.1016\u002FS0896-6273(00)80177-4",{"doi":4712},"10.1016\u002FS0896-6273(00)80177-4",{"id":21,"text":4714,"url":21,"identifiers":4715},"Schiavon, 1998, Mutations of the same sequence of the myelin P0 gene causing two different phenotypes, Hum. Mutat., 11, S217, 10.1002\u002Fhumu.1380110170",{"doi":4716},"10.1002\u002Fhumu.1380110170",{"id":21,"text":4718,"url":21,"identifiers":4719},"Timmerman, 1999, The Thr124Met mutation in the peripheral myelin protein zero (MPZ) gene is associated with a clinically distinct Charcot-Marie-Tooth phenotype, Brain, 122, 281, 10.1093\u002Fbrain\u002F122.2.281",{"doi":4720},"10.1093\u002Fbrain\u002F122.2.281",{"id":21,"text":4722,"url":21,"identifiers":4723},"Nelis, 1996, Estimation of the mutation frequencies in Charcot-Marie-Tooth disease type 1 and hereditary neuropathy with liability to pressure palsies: A European collaborative study, Eur. J. Hum. Genet., 4, 25, 10.1159\u002F000472166",{"doi":4724},"10.1159\u002F000472166",{"id":21,"text":4726,"url":21,"identifiers":4727},"Szigeti, 2006, Charcot-Marie-Tooth disease and related hereditary polyneuropathies: Molecular diagnostics determine aspects of medical management, Genet. Med., 8, 86, 10.1097\u002F01.gim.0000200160.29385.73",{"doi":4728},"10.1097\u002F01.gim.0000200160.29385.73",{"id":21,"text":4730,"url":21,"identifiers":4731},"Patel, 1990, Genetic mapping of autosomal dominant Charcot-Marie-Tooth disease in a large French-Acadian kindred: Identification of new linked markers on chromosome 17, Am. J. Hum. Genet., 46, 801",{},{"id":21,"text":4733,"url":21,"identifiers":4734},"Timmerman, 1990, Assignment of the Charcot-Marie-Tooth neuropathy type 1 (CMT 1a) gene to 17p11.2-p12, Am. J. Hum. Genet., 47, 680",{},{"id":21,"text":4736,"url":21,"identifiers":4737},"Raeymaekers, 1991, HMSN Collaborative Research Group Duplication in chromosome 17p11.2 in Charcot-Marie-Tooth neuropathy type 1a (CMT 1a), Neuromuscul. Disord., 1, 93, 10.1016\u002F0960-8966(91)90055-W",{"doi":4738},"10.1016\u002F0960-8966(91)90055-W",{"id":21,"text":4740,"url":21,"identifiers":4741},"Lupski, 1991, DNA duplication associated with Charcot-Marie-Tooth disease type 1A, Cell, 66, 219, 10.1016\u002F0092-8674(91)90613-4",{"doi":4742},"10.1016\u002F0092-8674(91)90613-4",{"id":21,"text":4744,"url":21,"identifiers":4745},"Lupski, J.R., and Stankiewicz, P. (2006). Genomic Disorders: The Genomic Basis of Disease, Humana Press. [1st ed.].",{"doi":4746},"10.1007\u002F978-1-59745-039-3",{"id":21,"text":4748,"url":21,"identifiers":4749},"Chance, 1993, DNA deletion associated with hereditary neuropathy with liability to pressure palsies, Cell, 72, 143, 10.1016\u002F0092-8674(93)90058-X",{"doi":4750},"10.1016\u002F0092-8674(93)90058-X",{"id":21,"text":4752,"url":21,"identifiers":4753},"Reiter, 1996, A recombination hotspot responsible for two inherited peripheral neuropathies is located near a mariner transposon-like element, Nat. Genet., 12, 288, 10.1038\u002Fng0396-288",{"doi":4754},"10.1038\u002Fng0396-288",{"id":21,"text":4756,"url":21,"identifiers":4757},"Kennerson, 1997, The Charcot-Marie-Tooth binary repeat contains a gene transcribed from the opposite strand of a partially duplicated region of the COX10 gene, Genomics, 46, 61, 10.1006\u002Fgeno.1997.5012",{"doi":4758},"10.1006\u002Fgeno.1997.5012",{"id":21,"text":4760,"url":21,"identifiers":4761},"Inoue, 2001, The 1.4 Mb CMT1A duplication\u002FHNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes, Genome Res., 11, 1018, 10.1101\u002Fgr.180401",{"doi":4762},"10.1101\u002Fgr.180401",{"id":21,"text":4764,"url":21,"identifiers":4765},"Matsunami, 1992, Peripheral myelin protein-22 gene maps in the duplication in chromosome 17p11.2 associated with Charcot-Marie-Tooth 1A, Nat. Genet., 1, 176, 10.1038\u002Fng0692-176",{"doi":4766},"10.1038\u002Fng0692-176",{"id":21,"text":4768,"url":21,"identifiers":4769},"Patel, 1992, The gene for the peripheral myelin protein PMP-22 is a candidate for Charcot-Marie-Tooth disease type 1A, Nat. Genet., 1, 159, 10.1038\u002Fng0692-159",{"doi":4770},"10.1038\u002Fng0692-159",{"id":21,"text":4772,"url":21,"identifiers":4773},"Timmerman, 1992, The peripheral myelin protein gene PMP-22 is contained within the Charcot-Marie-Tooth disease type 1A duplication, Nat. Genet., 1, 171, 10.1038\u002Fng0692-171",{"doi":4774},"10.1038\u002Fng0692-171",{"id":21,"text":4776,"url":21,"identifiers":4777},"Valentijn, 1992, The peripheral myelin gene PMP-22\u002FGAS-3 is duplicated in Charcot- Marie-Tooth disease type 1A, Nat. Genet., 1, 166, 10.1038\u002Fng0692-166",{"doi":4778},"10.1038\u002Fng0692-166",{"id":21,"text":4780,"url":21,"identifiers":4781},"Lupski, 1992, Gene dosage is a mechanism for Charcot-Marie-Tooth disease type 1A, Nat. Genet., 1, 29, 10.1038\u002Fng0492-29",{"doi":4782},"10.1038\u002Fng0492-29",{"id":21,"text":4784,"url":21,"identifiers":4785},"Palau, 1993, Origin of the de novo duplication in Charcot-Marie-Tooth disease type 1A: Unequal nonsister chromatid exchange during spermatogenesis, Hum. Mol. Genet., 2, 2031, 10.1093\u002Fhmg\u002F2.12.2031",{"doi":4786},"10.1093\u002Fhmg\u002F2.12.2031",{"id":21,"text":4788,"url":21,"identifiers":4789},"Zhang, 2010, Mechanisms for nonrecurrent genomic rearrangements associated with CMT1A or HNPP: Rare CNVs as a cause for missing heritability, Am. J. Hum. Genet., 86, 892, 10.1016\u002Fj.ajhg.2010.05.001",{"doi":4790},"10.1016\u002Fj.ajhg.2010.05.001",{"id":21,"text":4792,"url":21,"identifiers":4793},"Boone, 2011, Genomic medicine and neurological disease, Hum. Genet., 130, 103, 10.1007\u002Fs00439-011-1001-1",{"doi":4794},"10.1007\u002Fs00439-011-1001-1",{"id":21,"text":4796,"url":21,"identifiers":4797},"Stankiewicz, 2010, Structural variation in the human genome and its role in disease, Annu. Rev. Med., 61, 437, 10.1146\u002Fannurev-med-100708-204735",{"doi":4798},"10.1146\u002Fannurev-med-100708-204735",{"id":21,"text":4800,"url":21,"identifiers":4801},"Suter, 1992, Trembler mouse carries a point mutation in a myelin gene, Nature, 356, 241, 10.1038\u002F356241a0",{"doi":4802},"10.1038\u002F356241a0",{"id":21,"text":4804,"url":21,"identifiers":4805},"Suter, 1992, A leucine-to-proline mutation in the putative first transmembrane domain of the 22-kDa peripheral myelin protein in the trembler-J mouse, Proc. Natl. Acad. Sci. USA, 89, 4382, 10.1073\u002Fpnas.89.10.4382",{"doi":4806},"10.1073\u002Fpnas.89.10.4382",{"id":21,"text":4808,"url":21,"identifiers":4809},"Fledrich, 2012, Murine therapeutic models for Charcot-Marie-Tooth (CMT) disease, Br. Med. Bull., 102, 89, 10.1093\u002Fbmb\u002Flds010",{"doi":4810},"10.1093\u002Fbmb\u002Flds010",{"id":21,"text":4812,"url":21,"identifiers":4813},"Sereda, 2003, Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-Tooth disease (CMT-1A), Nat. Med., 9, 1533, 10.1038\u002Fnm957",{"doi":4814},"10.1038\u002Fnm957",{"id":21,"text":4816,"url":21,"identifiers":4817},"Passage, 2004, Ascorbic acid treatment corrects the phenotype of a mouse model of Charcot-Marie-Tooth disease, Nat. Med., 10, 396, 10.1038\u002Fnm1023",{"doi":4818},"10.1038\u002Fnm1023",{"id":21,"text":4820,"url":21,"identifiers":4821},"Verhamme, 2009, Oral high dose ascorbic acid treatment for one year in young CMT1A patients: A randomised, double-blind, placebo-controlled phase II trial, BMC Med., 7, 70, 10.1186\u002F1741-7015-7-70",{"doi":4822},"10.1186\u002F1741-7015-7-70",{"id":21,"text":4824,"url":21,"identifiers":4825},"Pareyson, 2008, Clinical and electrophysiological evaluation of 222 patients with Charcot-Marie-Tooth disease type 1A recruited in the CMT-TRIAAL (ascorbic acid therapy for Charcot-Marie-Tooth 1A disease), J. Neurol., 255, 104",{},{"id":21,"text":4827,"url":21,"identifiers":4828},"Pareyson, 2006, A multicenter, randomized, double-blind, placebo-controlled trial of long-term ascorbic acid treatment in Charcot-Marie-Tooth disease type 1A (CMT-TRIAAL): The study protocol [EudraCT no.: 2006-000032-27], Pharmacol. Res., 54, 436, 10.1016\u002Fj.phrs.2006.09.001",{"doi":4829},"10.1016\u002Fj.phrs.2006.09.001",{"id":21,"text":4831,"url":21,"identifiers":4832},"Burns, 2009, Ascorbic acid for Charcot-Marie-Tooth disease type 1A in children: A randomised, double-blind, placebo-controlled, safety and efficacy trial, Lancet Neurol., 8, 537, 10.1016\u002FS1474-4422(09)70108-5",{"doi":4833},"10.1016\u002FS1474-4422(09)70108-5",{"id":21,"text":4835,"url":21,"identifiers":4836},"Lewis, 2013, High-dosage ascorbic acid treatment in Charcot-Marie-Tooth disease type 1A: Results of a randomized, double-masked, controlled trial, JAMA Neurol., 70, 981, 10.1001\u002Fjamaneurol.2013.3178",{"doi":4837},"10.1001\u002Fjamaneurol.2013.3178",{"id":21,"text":4839,"url":21,"identifiers":4840},"Micallef, 2009, Effect of ascorbic acid in patients with Charcot-Marie-Tooth disease type 1A: A multicentre, randomised, double-blind, placebo-controlled trial, Lancet Neurol., 8, 1103, 10.1016\u002FS1474-4422(09)70260-1",{"doi":4841},"10.1016\u002FS1474-4422(09)70260-1",{"id":21,"text":4843,"url":21,"identifiers":4844},"Saporta, 2011, Charcot-Marie-Tooth disease subtypes and genetic testing strategies, Ann. Neurol., 69, 22, 10.1002\u002Fana.22166",{"doi":4845},"10.1002\u002Fana.22166",{"id":21,"text":4847,"url":21,"identifiers":4848},"Aretz, S., Rautenstrauss, B., and Timmerman, V. (2010). Clinical utility gene card for: HMSN\u002FHNPP HMSN types 1, 2, 3, 6 (CMT1,2,4, DSN, CHN, GAN, CCFDN, HNA); HNPP. Eur. J. Hum. Genet., 18.",{"doi":4849},"10.1038\u002Fejhg.2010.75",{"id":21,"text":4851,"url":21,"identifiers":4852},"Harding, 1980, Hereditary distal spinal muscular atrophy. A report on 34 cases and a review of the literature, J. Neurol. Sci., 45, 337, 10.1016\u002F0022-510X(80)90177-X",{"doi":4853},"10.1016\u002F0022-510X(80)90177-X",{"id":21,"text":4855,"url":21,"identifiers":4856},"Irobi, 2006, Unravelling the genetics of distal hereditary motor neuronopathies, NeuroMol. Med., 8, 131, 10.1385\u002FNMM:8:1-2:131",{"doi":4857},"10.1385\u002FNMM:8:1-2:131",{"id":21,"text":4859,"url":21,"identifiers":4860},"Timmerman, 1992, Linkage analysis of distal hereditary motor neuropathy type II (distal HMN II) in a single pedigree, J. Neurol. Sci., 109, 41, 10.1016\u002F0022-510X(92)90091-X",{"doi":4861},"10.1016\u002F0022-510X(92)90091-X",{"id":21,"text":4863,"url":21,"identifiers":4864},"Gyapay, 1994, The 1993–94 Genethon human genetic linkage map [see comments], Nat. Genet., 7, 246, 10.1038\u002Fng0694supp-246",{"doi":4865},"10.1038\u002Fng0694supp-246",{"id":21,"text":4867,"url":21,"identifiers":4868},"Timmerman, 1996, Distal hereditary motor neuropathy type II (distal HMN II): Mapping of a locus to chromosome 12q24, Hum. Mol. Genet., 5, 1065, 10.1093\u002Fhmg\u002F5.7.1065",{"doi":4869},"10.1093\u002Fhmg\u002F5.7.1065",{"id":21,"text":4871,"url":21,"identifiers":4872},"Irobi, 2000, A clone contig of 12q24.3 encompassing the distal hereditary motor neuropathy type II gene, Genomics, 65, 34, 10.1006\u002Fgeno.2000.6149",{"doi":4873},"10.1006\u002Fgeno.2000.6149",{"id":21,"text":4875,"url":21,"identifiers":4876},"Irobi, 2004, Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy, Nat. Genet., 36, 597, 10.1038\u002Fng1328",{"doi":4877},"10.1038\u002Fng1328",{"id":21,"text":4879,"url":21,"identifiers":4880},"Ismailov, 2001, A new locus for autosomal dominant Charcot-Marie-Tooth disease type 2 (CMT2F) maps to chromosome 7q11-q21, Eur. J. Hum. Genet., 9, 646, 10.1038\u002Fsj.ejhg.5200686",{"doi":4881},"10.1038\u002Fsj.ejhg.5200686",{"id":21,"text":4883,"url":21,"identifiers":4884},"Evgrafov, 2004, Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy, Nat. Genet., 36, 602, 10.1038\u002Fng1354",{"doi":4885},"10.1038\u002Fng1354",{"id":21,"text":4887,"url":21,"identifiers":4888},"Holmgren, A., Bouhy, D., and Timmerman, V. (2012). Molecular Biology of small HSPs associated with Peripheral Neuropathies. eLS.",{"doi":4889},"10.1002\u002F9780470015902.a0024294",{"id":21,"text":4891,"url":21,"identifiers":4892},"Krishnan, 2011, HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease, Nat. Med., 17, 968, 10.1038\u002Fnm.2396",{"doi":4893},"10.1038\u002Fnm.2396",{"id":21,"text":4895,"url":21,"identifiers":4896},"Saito, 1997, Linkage mapping of the gene for Charcot-Marie-Tooth disease type 2 to chromosome 1p (CMT2A) and the clinical features of CMT2A, Neurology, 49, 1630, 10.1212\u002FWNL.49.6.1630",{"doi":4897},"10.1212\u002FWNL.49.6.1630",{"id":21,"text":4899,"url":21,"identifiers":4900},"Zhao, 2001, Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta, Cell, 105, 587, 10.1016\u002FS0092-8674(01)00363-4",{"doi":4901},"10.1016\u002FS0092-8674(01)00363-4",{"id":21,"text":4903,"url":21,"identifiers":4904},"Zuchner, 2004, Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A, Nat. Genet., 36, 449, 10.1038\u002Fng1341",{"doi":4905},"10.1038\u002Fng1341",{"id":21,"text":4907,"url":21,"identifiers":4908},"Verhoeven, 2006, Mitofusin 2 mutation distribution and genotype\u002Fphenotype correlation in Charcot-Marie-Tooth type 2, Brain, 129, 2093, 10.1093\u002Fbrain\u002Fawl126",{"doi":4909},"10.1093\u002Fbrain\u002Fawl126",{"id":21,"text":4911,"url":21,"identifiers":4912},"Lv, 2013, Mitofusin 2 gene mutation causing early-onset CMT2A with different progressive courses, Clin. Neuropathol., 32, 16, 10.5414\u002FNP300464",{"doi":4913},"10.5414\u002FNP300464",{"id":21,"text":4915,"url":21,"identifiers":4916},"Chung, 2006, Early onset severe and late-onset mild Charcot-Marie-Tooth disease with mitofusin 2 (MFN2) mutations, Brain, 129, 2103, 10.1093\u002Fbrain\u002Fawl174",{"doi":4917},"10.1093\u002Fbrain\u002Fawl174",{"id":21,"text":4919,"url":21,"identifiers":4920},"Feely, 2011, MFN2 mutations cause severe phenotypes in most patients with CMT2A, Neurology, 76, 1690, 10.1212\u002FWNL.0b013e31821a441e",{"doi":4921},"10.1212\u002FWNL.0b013e31821a441e",{"id":21,"text":4923,"url":21,"identifiers":4924},"Jordanova, 2006, Axonal neuropathy with optic atrophy (HMSN VI) is caused by mutations in mitofusin 2, Ann. Neurol., 59, 276, 10.1002\u002Fana.20797",{"doi":4925},"10.1002\u002Fana.20797",{"id":21,"text":4927,"url":21,"identifiers":4928},"Zhu, 2005, Charcot-Marie-Tooth with pyramidal signs is genetically heterogeneous: Families with and without MFN2 mutations, Neurology, 65, 496, 10.1212\u002F01.wnl.0000171345.62270.29",{"doi":4929},"10.1212\u002F01.wnl.0000171345.62270.29",{"id":21,"text":4931,"url":21,"identifiers":4932},"McCorquodale, 2011, Mutation screening of mitofusin 2 in Charcot-Marie-Tooth disease type 2, J. Neurol., 258, 1234, 10.1007\u002Fs00415-011-5910-7",{"doi":4933},"10.1007\u002Fs00415-011-5910-7",{"id":21,"text":4935,"url":21,"identifiers":4936},"Weger, 2011, Fibulin-5 mutations link inherited neuropathies, age-related macular degeneration and hyperelastic skin, Brain, 134, 1839, 10.1093\u002Fbrain\u002Fawr076",{"doi":4937},"10.1093\u002Fbrain\u002Fawr076",{"id":21,"text":4939,"url":21,"identifiers":4940},"Zimon, 2012, Loss-of-function mutations in HINT1 cause axonal neuropathy with neuromyotonia, Nat. Genet., 44, 1080, 10.1038\u002Fng.2406",{"doi":4941},"10.1038\u002Fng.2406",{"id":21,"text":4943,"url":21,"identifiers":4944},"Azzedine, 2012, Molecular genetics of charcot-marie-tooth disease: From genes to genomes, Mol. Syndromol., 3, 204, 10.1159\u002F000343487",{"doi":4945},"10.1159\u002F000343487",{"id":21,"text":4947,"url":21,"identifiers":4948},"Rossor, 2013, Clinical implications of genetic advances in Charcot-Marie-Tooth disease, Nat. Rev. Neurol., 9, 562, 10.1038\u002Fnrneurol.2013.179",{"doi":4949},"10.1038\u002Fnrneurol.2013.179",{"id":21,"text":4951,"url":21,"identifiers":4952},"Montenegro, 2011, Exome sequencing allows for rapid gene identification in a Charcot-Marie-Tooth family, Ann. Neurol., 69, 464, 10.1002\u002Fana.22235",{"doi":4953},"10.1002\u002Fana.22235",{"id":21,"text":4955,"url":21,"identifiers":4956},"Gonzales, 2013, Exome sequencing identifies a significant variant in methionyl-tRNA synthetase (MARS) in a family with late-onset CMT2, J. Neurol. Neurosurg. Psychiatry, 84, 1247, 10.1136\u002Fjnnp-2013-305049",{"doi":4957},"10.1136\u002Fjnnp-2013-305049",{"id":21,"text":4959,"url":21,"identifiers":4960},"Peeters, 2013, Molecular defects in the motor adaptor BICD2 Cause proximal spinal muscular atrophy with autosomal-dominant inheritance, Am. J. Hum. Genet., 92, 955, 10.1016\u002Fj.ajhg.2013.04.013",{"doi":4961},"10.1016\u002Fj.ajhg.2013.04.013",{"id":21,"text":4963,"url":21,"identifiers":4964},"Neveling, 2013, Mutations in BICD2, which encodes a golgin and important motor adaptor, cause congenital autosomal-dominant spinal muscular atrophy, Am. J. Hum. Genet., 92, 946, 10.1016\u002Fj.ajhg.2013.04.011",{"doi":4965},"10.1016\u002Fj.ajhg.2013.04.011",{"id":21,"text":4967,"url":21,"identifiers":4968},"Oates, 2013, Mutations in BICD2 cause dominant congenital spinal muscular atrophy and hereditary spastic paraplegia, Am. J. Hum. Genet., 92, 965, 10.1016\u002Fj.ajhg.2013.04.018",{"doi":4969},"10.1016\u002Fj.ajhg.2013.04.018",{"id":21,"text":4971,"url":21,"identifiers":4972},"Kennerson, 2013, A new locus for X-linked dominant Charcot-Marie-Tooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene, Hum. Mol. Genet., 22, 1404, 10.1093\u002Fhmg\u002Fdds557",{"doi":4973},"10.1093\u002Fhmg\u002Fdds557",{"id":21,"text":4975,"url":21,"identifiers":4976},"Leipold, 2013, A de novo gain-of-function mutation in SCN11A causes loss of pain perception, Nat. Genet., 45, 1399, 10.1038\u002Fng.2767",{"doi":4977},"10.1038\u002Fng.2767",{"id":21,"text":4979,"url":21,"identifiers":4980},"Barwick, 2012, Defective presynaptic choline transport underlies hereditary motor neuropathy, Am. J. Hum. Genet., 91, 1103, 10.1016\u002Fj.ajhg.2012.09.019",{"doi":4981},"10.1016\u002Fj.ajhg.2012.09.019",{"id":21,"text":4983,"url":21,"identifiers":4984},"Tischfield, 2010, Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance, Cell, 140, 74, 10.1016\u002Fj.cell.2009.12.011",{"doi":4985},"10.1016\u002Fj.cell.2009.12.011",{"id":21,"text":4987,"url":21,"identifiers":4988},"Lupski, 2010, Whole-genome sequencing in a patient with Charcot-Marie-Tooth neuropathy, N. Engl. J. Med., 362, 1181, 10.1056\u002FNEJMoa0908094",{"doi":4989},"10.1056\u002FNEJMoa0908094",{"id":21,"text":4991,"url":21,"identifiers":4992},"2010, Peripheral neuropathies: Whole genome sequencing identifies causal variants in CMT, Nat. Rev. Neurol., 6, 424, 10.1038\u002Fnrneurol.2010.108",{"doi":4993},"10.1038\u002Fnrneurol.2010.108",{"id":21,"text":4995,"url":21,"identifiers":4996},"Senderek, 2003, Mutations in a gene encoding a novel SH3\u002FTPR domain protein cause autosomal recessive Charcot-Marie-Tooth type 4C neuropathy, Am. J. Hum. Genet., 73, 1106, 10.1086\u002F379525",{"doi":4997},"10.1086\u002F379525",{"id":21,"text":4999,"url":21,"identifiers":5000},"Gonzalez, 2013, GEnomes Management Application (GEM.app): A new software tool for large-scale collaborative genome analysis, Hum. Mutat., 34, 842, 10.1002\u002Fhumu.22305",{"doi":5001},"10.1002\u002Fhumu.22305",{"id":21,"text":5003,"url":21,"identifiers":5004},"Genome Variant Database for Human Diseases. Available online:http:\u002F\u002Fwww.genomics.med.miami.edu\u002F.",{},{"id":21,"text":5006,"url":21,"identifiers":5007},"Human Gene Mutation Database. Available online:http:\u002F\u002Fwww.biobase-international.com\u002Fproduct\u002Fhgmd\u002F.",{},{"id":21,"text":5009,"url":21,"identifiers":5010},"Inherited Neuropathy Consortium. Available online:http:\u002F\u002Frarediseasesnetwork.epi.usf.edu\u002FINC\u002F.",{},{"id":21,"text":5012,"url":21,"identifiers":5013},"Niemann, 2006, Pathornechanisms of mutant proteins in Charcot-Marie-Tooth disease, NeuroMol. Med., 8, 217, 10.1385\u002FNMM:8:1-2:217",{"doi":5014},"10.1385\u002FNMM:8:1-2:217",{"id":21,"text":5016,"url":21,"identifiers":5017},"Bouhy, 2013, Animal models and therapeutic prospects for Charcot-Marie-Tooth disease, Ann. Neurol., 74, 391, 10.1002\u002Fana.23987",{"doi":5018},"10.1002\u002Fana.23987",{"id":5020,"createTime":5021,"updateTime":5021,"relativeEntities":5022,"slug":5023,"properties":5024,"entityType":964,"verifyStatus":121,"verifyTime":5021,"verifyNote":1071,"languages":5039,"translateLanguages":21,"viewCount":22,"primaryUrl":5040,"fullTextUrl":21,"authors":5041,"publicationType":991,"publisherRelationship":5095,"citationCount":5149,"citationInfo":5150,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":5152,"openAccess":21,"references":5153,"isForceReanalyzing":1050},"ee47ccf7-b4fb-4c22-bacb-4e708c36f70d","2024-12-24T10:20:01.582+00:00",[],"The-Role-of-Mitogen-Activated-Protein-Kinase-Activated-Protein-Kinases-MAPKAPKs-in-Inflammation",{"mag":5025,"pmc":5027,"openalex":5029,"abstract":5031,"title":5033,"pm":5035,"doi":5037},{"VOID":5026},"2109862246",{"VOID":5028},"3899974",{"VOID":5030},"W2109862246",{"EN":5032},"\u003Cjats:p>Mitogen-activated protein kinase (MAPK) pathways are implicated in several cellular processes including proliferation, differentiation, apoptosis, cell survival, cell motility, metabolism, stress response and inflammation. MAPK pathways transmit and convert a plethora of extracellular signals by three consecutive phosphorylation events involving a MAPK kinase kinase, a MAPK kinase, and a MAPK. In turn MAPKs phosphorylate substrates, including other protein kinases referred to as MAPK-activated protein kinases (MAPKAPKs). Eleven mammalian MAPKAPKs have been identified: ribosomal-S6-kinases (RSK1-4), mitogen- and stress-activated kinases (MSK1-2), MAPK-interacting kinases (MNK1-2), MAPKAPK-2 (MK2), MAPKAPK-3 (MK3), and MAPKAPK-5 (MK5). The role of these MAPKAPKs in inflammation will be reviewed.\u003C\u002Fjats:p>",{"EN":5034},"The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation",{"VOID":5036},"24705157",{"VOID":5038},"10.3390\u002Fgenes4020101",[125],"https:\u002F\u002Fwww.mdpi.com\u002F2073-4425\u002F4\u002F2\u002F101",[5042,5061,5078],{"id":5043,"sortIndex":22,"researcher":21,"roles":5044,"affiliations":5045,"properties":5054,"displayName":5058,"givenName":21,"familyName":21},"f1dd4b5b-8702-4d81-b3cd-6c6a7dcc6252",[],[5046],{"id":5047,"sortIndex":22,"affiliation":5048,"properties":21},"917a6e46-9363-4c45-ab41-ee0035b419cf",{"id":5047,"createTime":21,"updateTime":21,"relativeEntities":5049,"slug":21,"properties":5050,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":5053,"statistic":21},[],{"title":5051},{"VI":5052},"Molecular Inflammation Research Group, Department of Medical 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C.N., and Ward, P.A. (2010). Fundamentals of Inflammation, Cambridge University Press. [1st].",{},{"id":21,"text":5158,"url":21,"identifiers":5159},"DiDonato, 2012, NF-kB and the link between inflammation and cancer, Immunol. Rev., 246, 379, 10.1111\u002Fj.1600-065X.2012.01099.x",{"doi":5160},"10.1111\u002Fj.1600-065X.2012.01099.x",{"id":21,"text":5162,"url":21,"identifiers":5163},"Kyriakis, 2012, Mammalian MAPK signal transduction pathways activated by stress and inflammation: A 10-year update, Physiol. Rev., 92, 689, 10.1152\u002Fphysrev.00028.2011",{"doi":5164},"10.1152\u002Fphysrev.00028.2011",{"id":21,"text":5166,"url":21,"identifiers":5167},"Newton, 2012, Signaling in innate immunity and inflammation, Cold Spring Harb. Perspect. Biol., 4, a006049, 10.1101\u002Fcshperspect.a006049",{"doi":5168},"10.1101\u002Fcshperspect.a006049",{"id":21,"text":5170,"url":21,"identifiers":5171},"Plenge, 2012, JAK and STAT signaling molecules in immunoregulation and immune-mediated disease, Immunity, 36, 542, 10.1016\u002Fj.immuni.2012.03.014",{"doi":5172},"10.1016\u002Fj.immuni.2012.03.014",{"id":21,"text":5174,"url":21,"identifiers":5175},"Cargnello, 2011, Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases, Microbiol. Mol. Biol. Rev., 75, 50, 10.1128\u002FMMBR.00031-10",{"doi":5176},"10.1128\u002FMMBR.00031-10",{"id":21,"text":5178,"url":21,"identifiers":5179},"Anjum, 2008, The RSK family of kinases: Emerging roles in cellular signaling, Nat. Rev. Mol. Cell. Biol., 9, 747, 10.1038\u002Fnrm2509",{"doi":5180},"10.1038\u002Fnrm2509",{"id":21,"text":5182,"url":21,"identifiers":5183},"Arthur, 2008, MSK activation and physiological roles, Front. Biosci., 13, 5866, 10.2741\u002F3122",{"doi":5184},"10.2741\u002F3122",{"id":21,"text":5186,"url":21,"identifiers":5187},"Buxade, 2008, The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases), Front. Biosci., 13, 5359, 10.2741\u002F3086",{"doi":5188},"10.2741\u002F3086",{"id":21,"text":5190,"url":21,"identifiers":5191},"Carriere, 2008, The RSK factors of activating the Ras\u002FMAPK signaling cascade, Front. Biosci., 13, 4258, 10.2741\u002F3003",{"doi":5192},"10.2741\u002F3003",{"id":21,"text":5194,"url":21,"identifiers":5195},"Ronkina, 2008, MK2 and MK3—A pair of isoenzymes, Front Biosci., 13, 5511, 10.2741\u002F3095",{"doi":5196},"10.2741\u002F3095",{"id":21,"text":5198,"url":21,"identifiers":5199},"Kostenko, 2011, Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated\u002Factivated protein kinase, World J. Biol. Chem., 2, 73, 10.4331\u002Fwjbc.v2.i5.73",{"doi":5200},"10.4331\u002Fwjbc.v2.i5.73",{"id":21,"text":5202,"url":21,"identifiers":5203},"Gaestel, 2006, MAPKAP kinases- MKs- two’s company, three’s a crowd, Nat. Rev. Mol. Cell. Biol., 7, 120, 10.1038\u002Fnrm1834",{"doi":5204},"10.1038\u002Fnrm1834",{"id":21,"text":5206,"url":21,"identifiers":5207},"Kotlyarov, 1999, MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis, Nat. Cell. Biol., 1, 94, 10.1038\u002F10061",{"doi":5208},"10.1038\u002F10061",{"id":21,"text":5210,"url":21,"identifiers":5211},"Ronkina, 2007, The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK, Mol. Cell. Biol., 27, 170, 10.1128\u002FMCB.01456-06",{"doi":5212},"10.1128\u002FMCB.01456-06",{"id":21,"text":5214,"url":21,"identifiers":5215},"Shiryaev, 2010, Mitogen-activated protein kinase p38 and MK2, MK3 and MK5: ménage à trois or ménage à quatre?, Cell. Signal., 22, 1185, 10.1016\u002Fj.cellsig.2010.03.002",{"doi":5216},"10.1016\u002Fj.cellsig.2010.03.002",{"id":21,"text":5218,"url":21,"identifiers":5219},"Kostenko, 2012, Tumor promoting and suppressing roles of the atypical signalling pathway ERK3\u002F4-MK5, J. Mol. Signal., 7, 9, 10.1186\u002F1750-2187-7-9",{"doi":5220},"10.1186\u002F1750-2187-7-9",{"id":21,"text":5222,"url":21,"identifiers":5223},"Shiryaev, 2012, Septin 8 is an interaction partner and in vitro substrate of MK5, World J. Biol. Chem., 3, 98, 10.4331\u002Fwjbc.v3.i5.98",{"doi":5224},"10.4331\u002Fwjbc.v3.i5.98",{"id":21,"text":5226,"url":21,"identifiers":5227},"Baeuerle, 1997, NF-kB as a frequent target for immunosuppressive and  anti-inflammatory molecules, Adv. Immunol., 65, 111",{},{"id":21,"text":5229,"url":21,"identifiers":5230},"Barnes, 1997, Nuclear factor-kappab: A pivotal transcription factor in chronic inflammatory diseases, N. Engl. J. Med., 336, 1066, 10.1056\u002FNEJM199704103361506",{"doi":5231},"10.1056\u002FNEJM199704103361506",{"id":21,"text":5233,"url":21,"identifiers":5234},"Baeuerle, 1996, NF-kB: Ten years after, Cell, 87, 13, 10.1016\u002FS0092-8674(00)81318-5",{"doi":5235},"10.1016\u002FS0092-8674(00)81318-5",{"id":21,"text":5237,"url":21,"identifiers":5238},"Ghoda, 1997, The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of the IkappaBalpha and stimulates its degradation in vitro, J. Biol. Chem., 272, 21281, 10.1074\u002Fjbc.272.34.21281",{"doi":5239},"10.1074\u002Fjbc.272.34.21281",{"id":21,"text":5241,"url":21,"identifiers":5242},"Schouten, 1997, IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase, EMBO J., 16, 3133, 10.1093\u002Femboj\u002F16.11.3133",{"doi":5243},"10.1093\u002Femboj\u002F16.11.3133",{"id":21,"text":5245,"url":21,"identifiers":5246},"Han, 1999, Angiotensin II induces interleukin-6 transcription in vascular smooth muscle cells through pleiotropic activation of nuclear factor-kappa B transcription factor, Circ. Res., 84, 695, 10.1161\u002F01.RES.84.6.695",{"doi":5247},"10.1161\u002F01.RES.84.6.695",{"id":21,"text":5249,"url":21,"identifiers":5250},"Suzuki, 2003, Inflammation and angiotensin II, Int. J. Biochem. Cell Biol., 35, 881, 10.1016\u002FS1357-2725(02)00271-6",{"doi":5251},"10.1016\u002FS1357-2725(02)00271-6",{"id":21,"text":5253,"url":21,"identifiers":5254},"Xu, 2011, Angiotensin II modulates interleukin-1b-induced inflammatory gene expression in vascular smooth muscle cells via interfering with ERK-NF-kB crosstalk, Biochem. Biophys. Res. Commun., 410, 543, 10.1016\u002Fj.bbrc.2011.06.021",{"doi":5255},"10.1016\u002Fj.bbrc.2011.06.021",{"id":21,"text":5257,"url":21,"identifiers":5258},"Doyen, 2010, Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkB kinase complex in vascular smooth muscle cells, J. Biol. Chem., 285, 30708, 10.1074\u002Fjbc.M110.126433",{"doi":5259},"10.1074\u002Fjbc.M110.126433",{"id":21,"text":5261,"url":21,"identifiers":5262},"Panta, 2004, ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK\u002Fextracellular signal-regulated kinase\u002Fpp90(rsk) signaling pathway in response to distinct forms of DNA damage, Mol. Cell. Biol., 24, 1823, 10.1128\u002FMCB.24.5.1823-1835.2004",{"doi":5263},"10.1128\u002FMCB.24.5.1823-1835.2004",{"id":21,"text":5265,"url":21,"identifiers":5266},"Zhang, 2005, A new cellular signaling mechanism for angiotensin II activation of NF-kB: An IkB-independent, RSK-mediated phosphorylation of p65, Arterioscler. Thromb. Vasc. Biol., 25, 1148, 10.1161\u002F01.ATV.0000164624.00099.e7",{"doi":5267},"10.1161\u002F01.ATV.0000164624.00099.e7",{"id":21,"text":5269,"url":21,"identifiers":5270},"Zhang, 2005, Dual pathways for nuclear factor kappaB activation by angiotensin II in vascular smooth muscle: Phosphorylation of p65 by IkappaB kinase and ribosomal kinase, Circ. Res., 97, 975, 10.1161\u002F01.RES.0000190589.52286.41",{"doi":5271},"10.1161\u002F01.RES.0000190589.52286.41",{"id":21,"text":5273,"url":21,"identifiers":5274},"Bohuslav, 2004, p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1, J. Biol. Chem., 279, 26115, 10.1074\u002Fjbc.M313509200",{"doi":5275},"10.1074\u002Fjbc.M313509200",{"id":21,"text":5277,"url":21,"identifiers":5278},"Vergnolle, 2004, A role for proteinase-activated receptor-1 in inflammatory bowel disease, J. Clin. Invest., 114, 1444, 10.1172\u002FJCI21689",{"doi":5279},"10.1172\u002FJCI21689",{"id":21,"text":5281,"url":21,"identifiers":5282},"Hou, 1998, Immunolocalization of protease-activated receptor-2 in skin: Receptor activation stimulates interleukin-8 secretion by keratinocytes in vitro, Immunology, 94, 356, 10.1046\u002Fj.1365-2567.1998.00528.x",{"doi":5283},"10.1046\u002Fj.1365-2567.1998.00528.x",{"id":21,"text":5285,"url":21,"identifiers":5286},"Asokananthan, 2002, Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells, J. Immunol., 168, 3577, 10.4049\u002Fjimmunol.168.7.3577",{"doi":5287},"10.4049\u002Fjimmunol.168.7.3577",{"id":21,"text":5289,"url":21,"identifiers":5290},"Wang, 2010, Proteinase-activated receptors induce interleukin-8 expression by intestinal epithelial cells through ERK\u002FRSK90 activation and histone acetylation, FASEB J., 24, 1971, 10.1096\u002Ffj.09-137646",{"doi":5291},"10.1096\u002Ffj.09-137646",{"id":21,"text":5293,"url":21,"identifiers":5294},"Eliopoulos, 2002, Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals, EMBO J., 21, 4831, 10.1093\u002Femboj\u002Fcdf478",{"doi":5295},"10.1093\u002Femboj\u002Fcdf478",{"id":21,"text":5297,"url":21,"identifiers":5298},"Tiraloche, 1999, Lipopolysaccharide modulates cyclooxygenase-2 transcriptionally and posttranscriptionally in human macrophages independently from endogenous IL-1b and TNF-a, J. Immunol., 163, 963, 10.4049\u002Fjimmunol.163.2.963",{"doi":5299},"10.4049\u002Fjimmunol.163.2.963",{"id":21,"text":5301,"url":21,"identifiers":5302},"Gilroy, 2000, New insights into the role of COX2 in inflammation, J. Mol. Med., 78, 121, 10.1007\u002Fs001090000094",{"doi":5303},"10.1007\u002Fs001090000094",{"id":21,"text":5305,"url":21,"identifiers":5306},"Agarwal, 2009, Eicosanoids in inflammation and cancer: the role of COX-2, Expert Rev. Clin. Immunol., 5, 145, 10.1586\u002F1744666X.5.2.145",{"doi":5307},"10.1586\u002F1744666X.5.2.145",{"id":21,"text":5309,"url":21,"identifiers":5310},"Zaru, 2007, The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways, Nat. Immunol., 8, 1227, 10.1038\u002Fni1517",{"doi":5311},"10.1038\u002Fni1517",{"id":21,"text":5313,"url":21,"identifiers":5314},"Wang, 2010, Mapping of phosphorylation sites in human MSK1 activated by a novel interaction with MRK-beta, Electrophoresis, 31, 1283, 10.1002\u002Felps.200900637",{"doi":5315},"10.1002\u002Felps.200900637",{"id":21,"text":5317,"url":21,"identifiers":5318},"Vermeulen, 2003, Transcriptional activation of NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1), EMBO J., 22, 1313, 10.1093\u002Femboj\u002Fcdg139",{"doi":5319},"10.1093\u002Femboj\u002Fcdg139",{"id":21,"text":5321,"url":21,"identifiers":5322},"Chen, 2005, NF-kappaB RelA phosphorylation regulates RelA acetylation, Mol. Cell. Biol., 25, 7966, 10.1128\u002FMCB.25.18.7966-7975.2005",{"doi":5323},"10.1128\u002FMCB.25.18.7966-7975.2005",{"id":21,"text":5325,"url":21,"identifiers":5326},"Gorska, 2007, MK2 controls the level of negative feedback in the NF-kB pathway and is essential for vascular permeability and airway inflammation, J. Exp. Med., 204, 1637, 10.1084\u002Fjem.20062621",{"doi":5327},"10.1084\u002Fjem.20062621",{"id":21,"text":5329,"url":21,"identifiers":5330},"Reber, 2009, Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation, PLoS One, 4, e4393, 10.1371\u002Fjournal.pone.0004393",{"doi":5331},"10.1371\u002Fjournal.pone.0004393",{"id":21,"text":5333,"url":21,"identifiers":5334},"Quivy, 2004, Regulation at multiple levels of NF-kB-mediated transactivation by protein acetylation, Biochem. Pharmacol., 68, 1221, 10.1016\u002Fj.bcp.2004.05.039",{"doi":5335},"10.1016\u002Fj.bcp.2004.05.039",{"id":21,"text":5337,"url":21,"identifiers":5338},"Spooren, 2010, Hunting for serine 276-phosphorylated p65, J. Biomed. Biotechnol., 2010, 275892, 10.1155\u002F2010\u002F275892",{"doi":5339},"10.1155\u002F2010\u002F275892",{"id":21,"text":5341,"url":21,"identifiers":5342},"Gesser, 2007, Dimethylfumarate specifically inhibits the mitogen and stress activated kinases 1 and 2 (MSK1\u002F2). Possible role for its anti-psoriatic effect, J. Invest. Dermatol., 127, 2129, 10.1038\u002Fsj.jid.5700859",{"doi":5343},"10.1038\u002Fsj.jid.5700859",{"id":21,"text":5345,"url":21,"identifiers":5346},"Seidel, 2011, IkBa glutathionylation and reduced histone H3 phosphorylation inhibit eotaxin and RANTES, Eur. Respir. J., 38, 1444, 10.1183\u002F09031936.00129610",{"doi":5347},"10.1183\u002F09031936.00129610",{"id":21,"text":5349,"url":21,"identifiers":5350},"Terazawa, 2012, Astaxanthin attenuates the UVB-induced secretion of prostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletion-independent manner, Exp. Dermatol., 21, 11, 10.1111\u002Fj.1600-0625.2012.01496.x",{"doi":5351},"10.1111\u002Fj.1600-0625.2012.01496.x",{"id":21,"text":5353,"url":21,"identifiers":5354},"Ospelt, 2010, TLRs and chronic inflammation, Int. J. Biochem. Cell. Biol., 42, 495, 10.1016\u002Fj.biocel.2009.10.010",{"doi":5355},"10.1016\u002Fj.biocel.2009.10.010",{"id":21,"text":5357,"url":21,"identifiers":5358},"Drexler, 2010, The role of Toll-like receptors in chronic inflammation, Int. J. Biochem. Cell. Biol., 42, 506, 10.1016\u002Fj.biocel.2009.10.009",{"doi":5359},"10.1016\u002Fj.biocel.2009.10.009",{"id":21,"text":5361,"url":21,"identifiers":5362},"Ananieva, 2008, The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signalling, Nat. Immunol., 9, 1028, 10.1038\u002Fni.1644",{"doi":5363},"10.1038\u002Fni.1644",{"id":21,"text":5365,"url":21,"identifiers":5366},"Edwards, 2010, The multikinase inhibitor Sorafenib reverses the suppression of IL-12 and enhancement of IL-10 by PGE2 in murine macrophages, Int. Immunopharmacol., 10, 1220, 10.1016\u002Fj.intimp.2010.07.002",{"doi":5367},"10.1016\u002Fj.intimp.2010.07.002",{"id":21,"text":5369,"url":21,"identifiers":5370},"Kim, 2008, The kinase p38alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression, Nat. Immunol., 9, 1019, 10.1038\u002Fni.1640",{"doi":5371},"10.1038\u002Fni.1640",{"id":21,"text":5373,"url":21,"identifiers":5374},"Darragh, 2010, MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages, Biochem. J., 425, 595, 10.1042\u002FBJ20091062",{"doi":5375},"10.1042\u002FBJ20091062",{"id":21,"text":5377,"url":21,"identifiers":5378},"Carl, 2004, Role of endogenous IL-10 in LPS-induced STAT3 activation and IL-1 receptor antagonist gene expression, J. Leukoc. Biol., 76, 735, 10.1189\u002Fjlb.1003526",{"doi":5379},"10.1189\u002Fjlb.1003526",{"id":21,"text":5381,"url":21,"identifiers":5382},"Zheng, 2001, IL-11: Insights in asthma from overexpression transgenic modelling, J. Allergy Clin. Immunol., 108, 489, 10.1067\u002Fmai.2001.118510",{"doi":5383},"10.1067\u002Fmai.2001.118510",{"id":21,"text":5385,"url":21,"identifiers":5386},"Suzuki, 2007, Expression of interleukin-17F in a mouse model of allergic asthma, Int. Arch. Allergy Immunol., 143, 89, 10.1159\u002F000101413",{"doi":5387},"10.1159\u002F000101413",{"id":21,"text":5389,"url":21,"identifiers":5390},"Barnes, 2008, Immunology of asthma and chronic obstructive pulmonary disease, Nat. Rev. Immunol., 8, 183, 10.1038\u002Fnri2254",{"doi":5391},"10.1038\u002Fnri2254",{"id":21,"text":5393,"url":21,"identifiers":5394},"Kawaguchi, 2009, Role of interleukin-17F in asthma, Inflamm. Allergy Drug Targets, 8, 383, 10.2174\u002F1871528110908050383",{"doi":5395},"10.2174\u002F1871528110908050383",{"id":21,"text":5397,"url":21,"identifiers":5398},"Kawaguchi, 2009, IL-17F-induced IL-11 release in bronchial epithelial cells via MSK1-CREB pathway, Am. J. Physiol. Lung Cell. Mol. Physiol., 296, L804, 10.1152\u002Fajplung.90607.2008",{"doi":5399},"10.1152\u002Fajplung.90607.2008",{"id":21,"text":5401,"url":21,"identifiers":5402},"Hoshino, 1998, Inhaled corticosteroid reduced lamina reticularis of the basement membrane by modulation of insulin-like growth factor (IGF)-I expression in bronchial asthma, Clin. Exp. Allergy, 28, 568, 10.1046\u002Fj.1365-2222.1998.00277.x",{"doi":5403},"10.1046\u002Fj.1365-2222.1998.00277.x",{"id":21,"text":5405,"url":21,"identifiers":5406},"Kawaguchi, 2010, Induction of insulin-like growth factor-I by interleukin-17F in bronchial epithelial cells, Clin. Exp. Allergy, 40, 1036, 10.1111\u002Fj.1365-2222.2010.03527.x",{"doi":5407},"10.1111\u002Fj.1365-2222.2010.03527.x",{"id":21,"text":5409,"url":21,"identifiers":5410},"Zhang, 2001, MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells, J. Biol. Chem., 276, 42534, 10.1074\u002Fjbc.M106044200",{"doi":5411},"10.1074\u002Fjbc.M106044200",{"id":21,"text":5413,"url":21,"identifiers":5414},"Wierenga, 2003, Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway, Exp. Hematol., 31, 398, 10.1016\u002FS0301-472X(03)00045-6",{"doi":5415},"10.1016\u002FS0301-472X(03)00045-6",{"id":21,"text":5417,"url":21,"identifiers":5418},"Hefner, 2000, Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinase, J. Biol. Chem., 275, 37542, 10.1074\u002Fjbc.M003395200",{"doi":5419},"10.1074\u002Fjbc.M003395200",{"id":21,"text":5421,"url":21,"identifiers":5422},"Bertelsen, 2011, The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice, Exp. Dermatol., 20, 140, 10.1111\u002Fj.1600-0625.2010.01153.x",{"doi":5423},"10.1111\u002Fj.1600-0625.2010.01153.x",{"id":21,"text":5425,"url":21,"identifiers":5426},"Chang, 2011, Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model, Cancer Invest., 29, 240, 10.3109\u002F07357907.2010.550594",{"doi":5427},"10.3109\u002F07357907.2010.550594",{"id":21,"text":5429,"url":21,"identifiers":5430},"Vermeulen, 2009, The versatile role of MSKs in transcriptional regulation, Trends Biochem. Sci., 34, 311, 10.1016\u002Fj.tibs.2009.02.007",{"doi":5431},"10.1016\u002Fj.tibs.2009.02.007",{"id":21,"text":5433,"url":21,"identifiers":5434},"Syrbu, 1999, Phosphorylation of cytosolic phospholipase A2 and the release of arachidonic acid in human neutrophils, J. Immunol., 162, 2334, 10.4049\u002Fjimmunol.162.4.2334",{"doi":5435},"10.4049\u002Fjimmunol.162.4.2334",{"id":21,"text":5437,"url":21,"identifiers":5438},"Niknami, 2009, Molecules in focus: Cytosolic phospholipase A2-alpha, Int. J. Biochem. Cell Biol., 41, 994, 10.1016\u002Fj.biocel.2008.07.017",{"doi":5439},"10.1016\u002Fj.biocel.2008.07.017",{"id":21,"text":5441,"url":21,"identifiers":5442},"Parra, 2005, The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1, Immunity, 23, 177, 10.1016\u002Fj.immuni.2005.06.009",{"doi":5443},"10.1016\u002Fj.immuni.2005.06.009",{"id":21,"text":5445,"url":21,"identifiers":5446},"Andersson, 2006, Posttranscriptional regulation of TNFalpha expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages, Cytokine, 33, 52, 10.1016\u002Fj.cyto.2005.11.017",{"doi":5447},"10.1016\u002Fj.cyto.2005.11.017",{"id":21,"text":5449,"url":21,"identifiers":5450},"Rowlett, 2008, MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages, Am. J. Physiol. Gastrointest. Liver Physiol., 294, G452, 10.1152\u002Fajpgi.00077.2007",{"doi":5451},"10.1152\u002Fajpgi.00077.2007",{"id":21,"text":5453,"url":21,"identifiers":5454},"Ziaei, 2012, MNK1 expression increases during cellular senescence and modulates the subcellular localization of hnRNP A1, Exp. Cell Res., 318, 500, 10.1016\u002Fj.yexcr.2011.12.015",{"doi":5455},"10.1016\u002Fj.yexcr.2011.12.015",{"id":21,"text":5457,"url":21,"identifiers":5458},"Lee, 1994, A protein kinase involved in the regulation of inflammatory cytokine biosynthesis, Nature, 372, 739, 10.1038\u002F372739a0",{"doi":5459},"10.1038\u002F372739a0",{"id":21,"text":5461,"url":21,"identifiers":5462},"Neininger, 2002, MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels, J. Biol. Chem., 277, 3065, 10.1074\u002Fjbc.C100685200",{"doi":5463},"10.1074\u002Fjbc.C100685200",{"id":21,"text":5465,"url":21,"identifiers":5466},"Culbert, 2006, MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity, J. Biol. Chem., 281, 23658, 10.1074\u002Fjbc.M513646200",{"doi":5467},"10.1074\u002Fjbc.M513646200",{"id":21,"text":5469,"url":21,"identifiers":5470},"Thomas, 2008, MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation—relevance in a mouse model of Parkinson’s disease, J. Neurochem., 105, 2039, 10.1111\u002Fj.1471-4159.2008.05310.x",{"doi":5471},"10.1111\u002Fj.1471-4159.2008.05310.x",{"id":21,"text":5473,"url":21,"identifiers":5474},"Tudor, 2009, The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages, FEBS Lett., 583, 1933, 10.1016\u002Fj.febslet.2009.04.039",{"doi":5475},"10.1016\u002Fj.febslet.2009.04.039",{"id":21,"text":5477,"url":21,"identifiers":5478},"Schottelius, 2010, The role of mitogen-activated protein kinase-activated protein kinase 2 in the p38\u002FTNF-a pathway of systemic and cutaneous inflammation, J. Invest. Dermatol., 130, 481, 10.1038\u002Fjid.2009.218",{"doi":5479},"10.1038\u002Fjid.2009.218",{"id":21,"text":5481,"url":21,"identifiers":5482},"Bode, 2012, The macrophage response towards LPS and its control through the p38MAPK-STAT3 axis, Cell. Signal., 24, 1185, 10.1016\u002Fj.cellsig.2012.01.018",{"doi":5483},"10.1016\u002Fj.cellsig.2012.01.018",{"id":21,"text":5485,"url":21,"identifiers":5486},"Johansen, 2006, Protein expression of TNF-alpha in psoriatic skin is regulated at a posttranscriptional level by MAPK-activated protein kinase 2, J. Immunol., 176, 1431, 10.4049\u002Fjimmunol.176.3.1431",{"doi":5487},"10.4049\u002Fjimmunol.176.3.1431",{"id":21,"text":5489,"url":21,"identifiers":5490},"Jagielska, 2012, Interleukin-1b assembles a proangiogenic signal module consisting of caveolin-1, tumor necrosis factor receptor-associated factor 6, p38-mitogen-activated protein kinase (MAPK), and MAPK-activated protein kinase 2 in endothelial cells, Arterioscler. Thromb. Vasc. Biol., 32, 1280, 10.1161\u002FATVBAHA.111.243477",{"doi":5491},"10.1161\u002FATVBAHA.111.243477",{"id":21,"text":5493,"url":21,"identifiers":5494},"Rousseau, 2002, Inhibition of SAPK2a\u002Fp38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs, EMBO J., 21, 6505, 10.1093\u002Femboj\u002Fcdf639",{"doi":5495},"10.1093\u002Femboj\u002Fcdf639",{"id":21,"text":5497,"url":21,"identifiers":5498},"Chrestensen, 2004, MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding, J. Biol. Chem., 279, 10176, 10.1074\u002Fjbc.M310486200",{"doi":5499},"10.1074\u002Fjbc.M310486200",{"id":21,"text":5501,"url":21,"identifiers":5502},"Clement, 2011, Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment, Mol. Cell. Biol., 31, 256, 10.1128\u002FMCB.00717-10",{"doi":5503},"10.1128\u002FMCB.00717-10",{"id":21,"text":5505,"url":21,"identifiers":5506},"Tran, 2003, Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by mitogen-activated protein kinase-activated protein kinase 2, Mol. Cell. Biol., 23, 7177, 10.1128\u002FMCB.23.20.7177-7188.2003",{"doi":5507},"10.1128\u002FMCB.23.20.7177-7188.2003",{"id":21,"text":5509,"url":21,"identifiers":5510},"Stoecklin, 2004, MK2-induced tristetraprolin: 14–3-3 complexes prevent stress granule association and ARE-mRNA decay, EMBO J., 23, 1313, 10.1038\u002Fsj.emboj.7600163",{"doi":5511},"10.1038\u002Fsj.emboj.7600163",{"id":21,"text":5513,"url":21,"identifiers":5514},"Ronkina, 2010, MAPKAP kinases MK2 and MK3 in inflammation: Complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin, Biochem. Pharmacol., 80, 1915, 10.1016\u002Fj.bcp.2010.06.021",{"doi":5515},"10.1016\u002Fj.bcp.2010.06.021",{"id":21,"text":5517,"url":21,"identifiers":5518},"Tiedje, 2012, The p38\u002FMK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation, PLoS Genet., 8, e1002977, 10.1371\u002Fjournal.pgen.1002977",{"doi":5519},"10.1371\u002Fjournal.pgen.1002977",{"id":21,"text":5521,"url":21,"identifiers":5522},"Marchese, 2010, MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibitingCAF1 deadenylase recruitment, J. Biol. Chem., 285, 27590, 10.1074\u002Fjbc.M110.136473",{"doi":5523},"10.1074\u002Fjbc.M110.136473",{"id":21,"text":5525,"url":21,"identifiers":5526},"Hitti, 2006, Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine\u002Furidine-rich element, Mol. Cell. Biol., 26, 2399, 10.1128\u002FMCB.26.6.2399-2407.2006",{"doi":5527},"10.1128\u002FMCB.26.6.2399-2407.2006",{"id":21,"text":5529,"url":21,"identifiers":5530},"Ronkina, 2011, Stress induced gene expression: A direct role for MAKAPK kinases in transcriptional activation of immediate early genes, Nucleic Acids Res., 39, 2503, 10.1093\u002Fnar\u002Fgkq1178",{"doi":5531},"10.1093\u002Fnar\u002Fgkq1178",{"id":21,"text":5533,"url":21,"identifiers":5534},"Winzen, 1999, The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism, EMBO J., 18, 4969, 10.1093\u002Femboj\u002F18.18.4969",{"doi":5535},"10.1093\u002Femboj\u002F18.18.4969",{"id":21,"text":5537,"url":21,"identifiers":5538},"Winzen, 2007, Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets, Mol. Cell. Biol., 27, 8388, 10.1128\u002FMCB.01493-07",{"doi":5539},"10.1128\u002FMCB.01493-07",{"id":21,"text":5541,"url":21,"identifiers":5542},"Stoecklin, 2008, Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolin, J. Biol. Chem., 283, 11689, 10.1074\u002Fjbc.M709657200",{"doi":5543},"10.1074\u002Fjbc.M709657200",{"id":21,"text":5545,"url":21,"identifiers":5546},"Ogilvie, 2009, Tristetraprolin mediates interferon-gamma mRNA decay, J. Biol. Chem., 284, 11216, 10.1074\u002Fjbc.M901229200",{"doi":5547},"10.1074\u002Fjbc.M901229200",{"id":21,"text":5549,"url":21,"identifiers":5550},"Zhao, 2011, Tristetraprolin regulates interleukin-6 expression through p38 MAPK-dependent affinity changes with mRNA 3’ untranslated region, J. Interferon Cytokine Res., 31, 629, 10.1089\u002Fjir.2010.0154",{"doi":5551},"10.1089\u002Fjir.2010.0154",{"id":21,"text":5553,"url":21,"identifiers":5554},"Xie, 2002, Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6, J. Biol. Chem., 277, 11802, 10.1074\u002Fjbc.M109296200",{"doi":5555},"10.1074\u002Fjbc.M109296200",{"id":21,"text":5557,"url":21,"identifiers":5558},"Wang, 2006, Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding, J. Biol. Chem., 281, 782, 10.1074\u002Fjbc.M505822200",{"doi":5559},"10.1074\u002Fjbc.M505822200",{"id":21,"text":5561,"url":21,"identifiers":5562},"Scheller, 2011, The pro- and anti-inflammatory properties of the cytokine interleukin-6, Biochim. Biophys. Acta, 1813, 878, 10.1016\u002Fj.bbamcr.2011.01.034",{"doi":5563},"10.1016\u002Fj.bbamcr.2011.01.034",{"id":21,"text":5565,"url":21,"identifiers":5566},"Radtke, 2010, Cross-regulation of cytokine signalling: Pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation, J. Cell Sci., 123, 947, 10.1242\u002Fjcs.065326",{"doi":5567},"10.1242\u002Fjcs.065326",{"id":21,"text":5569,"url":21,"identifiers":5570},"Heo, 2013, Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity, Arteriodcler. Thromb. Vasc. Biol., 33, 321, 10.1161\u002FATVBAHA.112.300619",{"doi":5571},"10.1161\u002FATVBAHA.112.300619",{"id":21,"text":5573,"url":21,"identifiers":5574},"Liu, 2005, Negative regulation of NF-kappaB signalling by PIAS1, Mol. Cell. Biol., 25, 1113, 10.1128\u002FMCB.25.3.1113-1123.2005",{"doi":5575},"10.1128\u002FMCB.25.3.1113-1123.2005",{"id":21,"text":5577,"url":21,"identifiers":5578},"Stokoe, 1992, Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins, FEBS Lett., 313, 307, 10.1016\u002F0014-5793(92)81216-9",{"doi":5579},"10.1016\u002F0014-5793(92)81216-9",{"id":21,"text":5581,"url":21,"identifiers":5582},"Clifton, 1996, A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress, FEBS Lett., 392, 209, 10.1016\u002F0014-5793(96)00816-2",{"doi":5583},"10.1016\u002F0014-5793(96)00816-2",{"id":21,"text":5585,"url":21,"identifiers":5586},"Kostenko, 2009, Heat shock protein 27 phosphorylation: Kinases, phosphatases, functions and pathology, Cell. Mol. Life Sci., 66, 3289, 10.1007\u002Fs00018-009-0086-3",{"doi":5587},"10.1007\u002Fs00018-009-0086-3",{"id":21,"text":5589,"url":21,"identifiers":5590},"Shiryaev, 2011, Distinct roles of MK2 and MK5 in cAMP\u002FPKA- and stress\u002Fp38MAPK-induced heat shock protein 27 phosphorylation, J. Mol. Signal., 6, 4, 10.1186\u002F1750-2187-6-4",{"doi":5591},"10.1186\u002F1750-2187-6-4",{"id":21,"text":5593,"url":21,"identifiers":5594},"Kato, 2011, Role of HSP27 in tumor necrosis factor-a-stimulated interleukin-6 synthesis in osteoblasts, Int. J. Mol. Med., 28, 887",{},{"id":21,"text":5596,"url":21,"identifiers":5597},"Tanabe, 2010, Phosphorylation status of heat shock protein 27 regulates the interleukin-1b-induced interleukin-6 synthesis in C6 glioma cells, Neuroscience, 170, 1028, 10.1016\u002Fj.neuroscience.2010.08.014",{"doi":5598},"10.1016\u002Fj.neuroscience.2010.08.014",{"id":21,"text":5600,"url":21,"identifiers":5601},"Alford, 2007, Heat shock protein 27 functions in inflammatory gene expression and transforming growth  factor-beta-activated kinase-1 (TAK-1)-mediated signaling, J. Biol. Chem., 282, 6232, 10.1074\u002Fjbc.M610987200",{"doi":5602},"10.1074\u002Fjbc.M610987200",{"id":21,"text":5604,"url":21,"identifiers":5605},"Lasa, 2000, Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade, Mol. Cell. Biol., 20, 4265, 10.1128\u002FMCB.20.12.4265-4274.2000",{"doi":5606},"10.1128\u002FMCB.20.12.4265-4274.2000",{"id":21,"text":5608,"url":21,"identifiers":5609},"De, 2000, Exaggerated human monocyte IL-10 concomitant to minimal TNF-alpha induction by heat-shock protein (Hsp27) suggests Hsp27 is primarily an antiinflammatory stimulus, J. Immunol., 165, 3951, 10.4049\u002Fjimmunol.165.7.3951",{"doi":5610},"10.4049\u002Fjimmunol.165.7.3951",{"id":21,"text":5612,"url":21,"identifiers":5613},"Park, 2003, Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation, J. Biol. Chem., 278, 35272, 10.1074\u002Fjbc.M305095200",{"doi":5614},"10.1074\u002Fjbc.M305095200",{"id":21,"text":5616,"url":21,"identifiers":5617},"Sinsimer, 2008, Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay, Mol. Cell. Biol., 28, 5223, 10.1128\u002FMCB.00431-08",{"doi":5618},"10.1128\u002FMCB.00431-08",{"id":21,"text":5620,"url":21,"identifiers":5621},"Kubisch, 2004, Overexpression of heat shock protein Hsp27 protects against cerulean-induced pancreatitis, Gastroenterology, 127, 275, 10.1053\u002Fj.gastro.2004.04.005",{"doi":5622},"10.1053\u002Fj.gastro.2004.04.005",{"id":21,"text":5624,"url":21,"identifiers":5625},"Funding, 2009, Reduced oxazolone-induced skin inflammation in MAPKAP kinase 2 knockout mice, J. Invest. Dermatol., 129, 891, 10.1038\u002Fjid.2008.322",{"doi":5626},"10.1038\u002Fjid.2008.322",{"id":21,"text":5628,"url":21,"identifiers":5629},"Johansen, 2009, MK2 regulates the early stages of skin tumor promotion, Carcinogenesis, 30, 2100, 10.1093\u002Fcarcin\u002Fbgp238",{"doi":5630},"10.1093\u002Fcarcin\u002Fbgp238",{"id":21,"text":5632,"url":21,"identifiers":5633},"Fyhrquist, 2010, MK2 signaling: lessons on tissue specificity in modulation of inflammation, J. Invest. Dermatol., 130, 342, 10.1038\u002Fjid.2009.372",{"doi":5634},"10.1038\u002Fjid.2009.372",{"id":21,"text":5636,"url":21,"identifiers":5637},"Li, 2011, Unfolded protein response signaling and MAP kinase pathways underlie pathogenesis of arsenic-induced cutaneous inflammation, Cancer Prev. Res., 4, 2101, 10.1158\u002F1940-6207.CAPR-11-0343",{"doi":5638},"10.1158\u002F1940-6207.CAPR-11-0343",{"id":21,"text":5640,"url":21,"identifiers":5641},"Pierce, 2011, Arsenic exposure, dietary patterns, and skin lesion risk in Bangladesh: A prospective study, Am. J. Epidemiol., 173, 345, 10.1093\u002Faje\u002Fkwq366",{"doi":5642},"10.1093\u002Faje\u002Fkwq366",{"id":21,"text":5644,"url":21,"identifiers":5645},"Tietz, 2006, Gene deletion of MK2 inhibits TNF-a and IL-6 and protects against cerulein-induced pancreatitis, Am. J. Physiol. Gastrointest. Liver Physiol., 290, G1298, 10.1152\u002Fajpgi.00530.2005",{"doi":5646},"10.1152\u002Fajpgi.00530.2005",{"id":21,"text":5648,"url":21,"identifiers":5649},"Li, 2009, Regulation of HSP60 and the role of MK2 in a new model of severe experimental pancreatitis, Am. J. Physiol. Gastrointest. Liver Physiol., 297, G981, 10.1152\u002Fajpgi.00225.2009",{"doi":5650},"10.1152\u002Fajpgi.00225.2009",{"id":21,"text":5652,"url":21,"identifiers":5653},"Michler, 2012, Activation of cannabinoid receptor 2 reduces inflammation in acute experimental pancreatitis via intra-acinar activation of p38 and MK2-dependent mechanisms, Am. J. Physiol. Gastrointest. Liver Physiol., 304, G181, 10.1152\u002Fajpgi.00133.2012",{"doi":5654},"10.1152\u002Fajpgi.00133.2012",{"id":21,"text":5656,"url":21,"identifiers":5657},"Wagner, 2000, CEP-1347 inhibits caerulein-induced rat pancreatic JNK activation and ameliorates caerulein pancreatitis, Am. J. Physiol. Gastrointest. Liver Physiol., 278, G165, 10.1152\u002Fajpgi.2000.278.1.G165",{"doi":5658},"10.1152\u002Fajpgi.2000.278.1.G165",{"id":21,"text":5660,"url":21,"identifiers":5661},"Yoshizuka, 2012, PRAK suppresses oncogenic ras-induced hematopoietic cancer development by antagonizing the JNK pathway, Mol. Cancer Res., 10, 810, 10.1158\u002F1541-7786.MCR-11-0576",{"doi":5662},"10.1158\u002F1541-7786.MCR-11-0576",{"id":21,"text":5664,"url":21,"identifiers":5665},"Lin, 2001, IL-6 inhibits apoptosis and retains oxidative DNA lesions in human gastric cancer AGS cells through up-regulation of anti-apoptotic gene mcl-1, Carcinogenesis, 22, 1947, 10.1093\u002Fcarcin\u002F22.12.1947",{"doi":5666},"10.1093\u002Fcarcin\u002F22.12.1947",{"id":21,"text":5668,"url":21,"identifiers":5669},"Poornima, 2006, Diabetic cardiomyopathy: The search for a unifying hypothesis, Circ. Res., 98, 596, 10.1161\u002F01.RES.0000207406.94146.c2",{"doi":5670},"10.1161\u002F01.RES.0000207406.94146.c2",{"id":21,"text":5672,"url":21,"identifiers":5673},"Thandavarayan, 2011, Depletion of 14–3-3 protein exacerbates cardiac oxidative stress, inflammation and remodelling process via modulation of MAPK\u002FNF-kB signalling pathways after streptozotocin-induced diabetes mellitus, Cell. Physiol. Biochem., 28, 911, 10.1159\u002F000335805",{"doi":5674},"10.1159\u002F000335805",{"id":21,"text":5676,"url":21,"identifiers":5677},"Wang, 2002, Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice, J. Biol. Chem., 277, 43969, 10.1074\u002Fjbc.M206837200",{"doi":5678},"10.1074\u002Fjbc.M206837200",{"id":21,"text":5680,"url":21,"identifiers":5681},"Trentham, 1977, Autoimmunity type II collagen and experimental model of arthritis, J. Exp. Med., 146, 857, 10.1084\u002Fjem.146.3.857",{"doi":5682},"10.1084\u002Fjem.146.3.857",{"id":21,"text":5684,"url":21,"identifiers":5685},"Hegen, 2006, MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis, J. Immunol., 177, 1913, 10.4049\u002Fjimmunol.177.3.1913",{"doi":5686},"10.4049\u002Fjimmunol.177.3.1913",{"id":21,"text":5688,"url":21,"identifiers":5689},"Jagavelu, 2007, Systemic deficiency of the MAP kinase-activated protein kinase 2 reduces atherosclerosis in hypercholesterolemic mice, Circ. Res., 101, 1104, 10.1161\u002FCIRCRESAHA.107.156075",{"doi":5690},"10.1161\u002FCIRCRESAHA.107.156075",{"id":21,"text":5692,"url":21,"identifiers":5693},"Ebrahimian, 2011, Mitogen-activated protein kinase-activated protein kinase 2 in angiotensin II-induced inflammation and hypertension: Regulation of oxidative stress, Hypertension, 57, 245, 10.1161\u002FHYPERTENSIONAHA.110.159889",{"doi":5694},"10.1161\u002FHYPERTENSIONAHA.110.159889",{"id":21,"text":5696,"url":21,"identifiers":5697},"Li, 2011, Silencing mitogen-activated protein kinase-activated protein kinase-2 arrests inflammatory bone loss, J. Pharmacol. Exp. Ther., 336, 633, 10.1124\u002Fjpet.110.172395",{"doi":5698},"10.1124\u002Fjpet.110.172395",{"id":21,"text":5700,"url":21,"identifiers":5701},"Jones, 2009, Mitogen-activated kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology, Ostearthritis Cartilage, 17, 124, 10.1016\u002Fj.joca.2008.05.001",{"doi":5702},"10.1016\u002Fj.joca.2008.05.001",{"id":21,"text":5704,"url":21,"identifiers":5705},"Braun, 2012, Mitogen-activated protein kinase 2 (MK2) regulates physiological and pathological bone turnover, J. Bone Miner. Res., 28, 936, 10.1002\u002Fjbmr.1816",{"doi":5706},"10.1002\u002Fjbmr.1816",{"id":21,"text":5708,"url":21,"identifiers":5709},"Feng, 2011, The role of p38 mitogen-activated protein kinase in the pathogenesis of inflammatory bowel disease, J. Dig. Dis., 12, 327, 10.1111\u002Fj.1751-2980.2011.00525.x",{"doi":5710},"10.1111\u002Fj.1751-2980.2011.00525.x",{"id":21,"text":5712,"url":21,"identifiers":5713},"Ghasemlou, 2010, Mitogen-activated protein kinase-activated protein kinase 2 (MK2) contributes to secondary damage after spinal cord injury, J. Neurosci., 30, 13750, 10.1523\u002FJNEUROSCI.2998-10.2010",{"doi":5714},"10.1523\u002FJNEUROSCI.2998-10.2010",{"id":21,"text":5716,"url":21,"identifiers":5717},"Ehlting, 2011, Distinct functions of the mitogen-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) by preventing negative regulatory effects of MK3, J. Biol. Chem., 286, 24113, 10.1074\u002Fjbc.M111.235275",{"doi":5718},"10.1074\u002Fjbc.M111.235275",{"id":21,"text":5720,"url":21,"identifiers":5721},"Lang, 2005, Tuning of macrophage responses by Stat3-inducing cytokines: molecular mechanisms and consequences in infection, Immunobiology, 210, 63, 10.1016\u002Fj.imbio.2005.05.001",{"doi":5722},"10.1016\u002Fj.imbio.2005.05.001",{"id":21,"text":5724,"url":21,"identifiers":5725},"Shi, 2003, Elimination of protein kinase MK5\u002FPRAK activity by targeted homologous recombination, Mol. Cell. Biol., 23, 7732, 10.1128\u002FMCB.23.21.7732-7741.2003",{"doi":5726},"10.1128\u002FMCB.23.21.7732-7741.2003",{"id":21,"text":5728,"url":21,"identifiers":5729},"Cohen, 2009, Targeting protein kinases for the development of anti-inflammatory drugs, Curr. Opin. Vell Biol., 21, 317, 10.1016\u002Fj.ceb.2009.01.015",{"doi":5730},"10.1016\u002Fj.ceb.2009.01.015",{"id":21,"text":5732,"url":21,"identifiers":5733},"Gaestel, 2009, Targeting innate immunity protein kinase signaling in inflammation, Nat. Rev. Drug Discov., 8, 480, 10.1038\u002Fnrd2829",{"doi":5734},"10.1038\u002Fnrd2829",{"id":21,"text":5736,"url":21,"identifiers":5737},"Cohen, 2005, Structural bioinformatics-based design of selective, irreversible kinase inhibitors, Science, 308, 1318, 10.1126\u002Fscience1108367",{"doi":5738},"10.1126\u002Fscience1108367",{"id":21,"text":5740,"url":21,"identifiers":5741},"Maloney, 2005, Synthesis of a potent and selective inhibitor of p90 Rsk, Org. Lett., 7, 1097, 10.1021\u002Fol0500463",{"doi":5742},"10.1021\u002Fol0500463",{"id":21,"text":5744,"url":21,"identifiers":5745},"Nguyen, 2006, Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore, Bioorg. Med. Chem., 14, 6097, 10.1016\u002Fj.bmc.2006.05.001",{"doi":5746},"10.1016\u002Fj.bmc.2006.05.001",{"id":21,"text":5748,"url":21,"identifiers":5749},"Smith, 2006, Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser\u002Fthr kinase, RSK, Bioorg. Med. Chem., 14, 6034, 10.1016\u002Fj.bmc.2006.05.009",{"doi":5750},"10.1016\u002Fj.bmc.2006.05.009",{"id":21,"text":5752,"url":21,"identifiers":5753},"Sapkota, 2007, BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo, Biochem. J., 401, 29, 10.1042\u002FBJ20061088",{"doi":5754},"10.1042\u002FBJ20061088",{"id":21,"text":5756,"url":21,"identifiers":5757},"Shan, 2010, Synthesis of SL0101 carbasugar analogues: carbasugars via Pd-catalyzed cyclitolization and post-cyclitolization transformations, Org. Lett., 12, 2986, 10.1021\u002Fol101009q",{"doi":5758},"10.1021\u002Fol101009q",{"id":21,"text":5760,"url":21,"identifiers":5761},"Hilinski, 2012, Analogs of the RSK inhibitor SL0101: Optimization of in vitro biological stability, Bioorg. Med. Chem. Lett., 22, 3244, 10.1016\u002Fj.bmcl.2012.03.033",{"doi":5762},"10.1016\u002Fj.bmcl.2012.03.033",{"id":21,"text":5764,"url":21,"identifiers":5765},"Bain, 2007, The selectivity of protein kinase inhibitors: A further update, Biochem. J., 408, 297, 10.1042\u002FBJ20070797",{"doi":5766},"10.1042\u002FBJ20070797",{"id":21,"text":5768,"url":21,"identifiers":5769},"Bamford, M.J., Alberti, M.J., Bailey, N., Davies, S., Dean, D.K., Gaiba, A., Garland, S., Harling, J.D., Jung, D.K., Panchal, T.A., Parr, C.A., Steadman, J.G., Takle, A.K., Townsend, J.T., Wilson, D.M., and Witherington, J. (1H-imidazo[4,5-c]pyridine-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors. Bioorg. Med. Chem. Lett., 15, 3402–3406.",{"doi":5770},"10.1016\u002Fj.bmcl.2005.05.021",{"id":21,"text":5772,"url":21,"identifiers":5773},"Bamford, M.J., Bailey, N., Davies, S., Dean, D.K., Francis, L., Panchal, T.A., Parr, C.A., Sehmi, S., Steadman, J.G., Takle, A.K., and Townsend, J.T. (1H-imidazo[4,5-c]pyridine-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: Further optimisation as highly potent and selective MSK-1-inhibitors. Bioorg. Med. Chem. Lett., 15, 3407–3411.",{"doi":5774},"10.1016\u002Fj.bmcl.2005.05.020",{"id":21,"text":5776,"url":21,"identifiers":5777},"Naqvi, 2012, Characterization of the cellular action of the MSK inhibitor SB-747651A, Biochem. J., 441, 347, 10.1042\u002FBJ20110970",{"doi":5778},"10.1042\u002FBJ20110970",{"id":21,"text":5780,"url":21,"identifiers":5781},"Beck, 2008, Altered subcellular distribution induced by glucocorticoids contributes to NF-kappaB inhibition, EMBO J., 27, 1682, 10.1038\u002Femboj.2008.95",{"doi":5782},"10.1038\u002Femboj.2008.95",{"id":21,"text":5784,"url":21,"identifiers":5785},"Barnes, 2009, Glucocorticoid resistance in inflammatory diseases, Lancet, 373, 1905, 10.1016\u002FS0140-6736(09)60326-3",{"doi":5786},"10.1016\u002FS0140-6736(09)60326-3",{"id":21,"text":5788,"url":21,"identifiers":5789},"Knauf, 2001, Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2, Mol. Cell. Biol., 21, 5500, 10.1128\u002FMCB.21.16.5500-5511.2001",{"doi":5790},"10.1128\u002FMCB.21.16.5500-5511.2001",{"id":21,"text":5792,"url":21,"identifiers":5793},"Cherla, 2006, Shiga toxin 1-induced cytokine production is mediated by MAP kinase pathways and translation initiation factor eIF4E in the macrophage-like THP-1 cells line, J. Leukoc. Biol., 79, 397, 10.1189\u002Fjlb.0605313",{"doi":5794},"10.1189\u002Fjlb.0605313",{"id":21,"text":5796,"url":21,"identifiers":5797},"Kjellerup, 2008, Pro-inflammatory cytokines release in keratinocytes is mediated through the MAPK signal-integrating kinases, Exp. Dermatol., 17, 498, 10.1111\u002Fj.1600-0625.2007.00672.x",{"doi":5798},"10.1111\u002Fj.1600-0625.2007.00672.x",{"id":21,"text":5800,"url":21,"identifiers":5801},"Mourey, 2010, A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha and has oral anti-inflammatory efficacy in acute and chronic models of inflammation, J. Pharmacol. Exp. Ther., 333, 797, 10.1124\u002Fjpet.110.166173",{"doi":5802},"10.1124\u002Fjpet.110.166173",{"id":21,"text":5804,"url":21,"identifiers":5805},"Kosugi, 2012, Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an anti-inflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach, J. Med. Chem., 55, 6700, 10.1021\u002Fjm300411k",{"doi":5806},"10.1021\u002Fjm300411k",{"id":21,"text":5808,"url":21,"identifiers":5809},"Wu, 2007, The discovery of carboline analogs as potent MAPKAP-K2 inhibitors, Bioorg. Med. Chem. Lett., 17, 4664, 10.1016\u002Fj.bmcl.2007.05.101",{"doi":5810},"10.1016\u002Fj.bmcl.2007.05.101",{"id":21,"text":5812,"url":21,"identifiers":5813},"Schlapbach, 2008, Pyrrolo-pyrimidones: a novel class of MK2 inhibitors with potent cellular activity, Bioorg. Med. Chem. Lett., 18, 6142, 10.1016\u002Fj.bmcl.2008.10.039",{"doi":5814},"10.1016\u002Fj.bmcl.2008.10.039",{"id":21,"text":5816,"url":21,"identifiers":5817},"Revesz, 2010, In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors, Part I, Bioorg. Med. Chem. Lett., 20, 4715, 10.1016\u002Fj.bmcl.2010.04.024",{"doi":5818},"10.1016\u002Fj.bmcl.2010.04.024",{"id":21,"text":5820,"url":21,"identifiers":5821},"Velcicky, 2010, Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy, Bioorg. Med. Chem. Lett., 20, 1293, 10.1016\u002Fj.bmcl.2009.10.138",{"doi":5822},"10.1016\u002Fj.bmcl.2009.10.138",{"id":21,"text":5824,"url":21,"identifiers":5825},"Kaptein, 2011, Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 inhibitors, Bioorg. Med. Chem. Lett., 21, 3823, 10.1016\u002Fj.bmcl.2011.04.016",{"doi":5826},"10.1016\u002Fj.bmcl.2011.04.016",{"id":21,"text":5828,"url":21,"identifiers":5829},"Huang, 2012, A three-step protocol for lead optimization: quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors, Bioorg. Med. Chem. Lett., 22, 65, 10.1016\u002Fj.bmcl.2011.11.074",{"doi":5830},"10.1016\u002Fj.bmcl.2011.11.074",{"id":21,"text":5832,"url":21,"identifiers":5833},"Coxon, 2003, MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils, Cell. Signal., 15, 993, 10.1016\u002FS0898-6568(03)00074-3",{"doi":5834},"10.1016\u002FS0898-6568(03)00074-3",{"id":21,"text":5836,"url":21,"identifiers":5837},"Lopes, 2009, Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP kinase 2 inhibitor, Biochem. Biophys. Res. Commun., 382, 539, 10.1016\u002Fj.bbrc.2009.03.056",{"doi":5838},"10.1016\u002Fj.bbrc.2009.03.056",{"id":21,"text":5840,"url":21,"identifiers":5841},"Brugnano, 2011, Cell-penetrating peptides can confer biological function: regulation of inflammatory cytokines in human monocytes by MK2 inhibitor peptides, J. Control Release, 155, 128, 10.1016\u002Fj.jconrel.2011.05.007",{"doi":5842},"10.1016\u002Fj.jconrel.2011.05.007",{"id":21,"text":5844,"url":21,"identifiers":5845},"Muto, 2012, Inhibition of mitogen activated protein kinase activated protein kinase II with MMI-0100 reduces intimal hyperplasia ex vivo and in vivo, Vascul. Pharmacol., 56, 47, 10.1016\u002Fj.vph.2011.07.008",{"doi":5846},"10.1016\u002Fj.vph.2011.07.008",{"id":21,"text":5848,"url":21,"identifiers":5849},"Kostenko, 2011, The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5\u002FPRAK) inhibitor, Cell. Mol. Life Sci., 68, 289, 10.1007\u002Fs00018-010-0452-1",{"doi":5850},"10.1007\u002Fs00018-010-0452-1",{"id":21,"text":5852,"url":21,"identifiers":5853},"Andrews, 2009, Small molecules against the novel target MAPKAPK5 show bone protection and anti-inflammatory activity in in vivo models of rheumatoid arthritis, Ann. Rheum. Dis., 68, 590",{},{"id":21,"text":5855,"url":21,"identifiers":5856},"Anwar, 2011, The kinase inhibitor SFV785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly, PLoS One, 6, e23246, 10.1371\u002Fjournal.pone.0023246",{"doi":5857},"10.1371\u002Fjournal.pone.0023246",{"id":21,"text":5859,"url":21,"identifiers":5860},"Andrews, 2012, Discovery of a series of imidazopyrazine small molecule inhibitors of the kinase MAPKAPK5, that show activity using in vitro and in vivo models of rheumatoid arthritis, Bioorg. Med. Chem. Lett., 22, 2266, 10.1016\u002Fj.bmcl.2012.01.077",{"doi":5861},"10.1016\u002Fj.bmcl.2012.01.077",{"id":21,"text":5863,"url":21,"identifiers":5864},"Namour, 2012, Pharmacokinetics, safety, and tolerability of GLPG0259, a mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5) inhibitor, given as single and multiple doses to healthy male subject, Drugs R D, 12, 141, 10.2165\u002F11633120-000000000-00000",{"doi":5865},"10.2165\u002F11633120-000000000-00000",{"id":21,"text":5867,"url":21,"identifiers":5868},"Westhovens, R., De Keyser, F., Rekalov, D., Nasonov, E.L., Beetens, J., Van der Aa, A., Wigerinck, P., Namour, F., Vanhoutte, F., and Durez, P. (2012). Oral administration of GLPG0259, an inhibitor of MAPKAPK5, a new target for the treatment of rheumatoid arthritis: A phase II, randomised double-blind, placebo-controlled, multicentre trial. Ann. Rheum. Dis.",{"doi":5869},"10.1136\u002Fannrheumdis-2012-202221",{"id":21,"text":5871,"url":21,"identifiers":5872},"Dong, 2008, Repression of gene expression by unphosphorylated NF-kappaB p65 through epigenetic mechanisms, Genes Dev., 22, 1159, 10.1101\u002Fgad.1657408",{"doi":5873},"10.1101\u002Fgad.1657408",{"id":5875,"createTime":5876,"updateTime":5876,"relativeEntities":5877,"slug":5878,"properties":5879,"entityType":964,"verifyStatus":121,"verifyTime":5876,"verifyNote":1071,"languages":5894,"translateLanguages":21,"viewCount":22,"primaryUrl":5895,"fullTextUrl":21,"authors":5896,"publicationType":991,"publisherRelationship":6003,"citationCount":6057,"citationInfo":6058,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":6060,"openAccess":21,"references":6061,"isForceReanalyzing":1050},"ba0aca38-7633-4044-82f3-174cbf31a04f","2024-09-17T13:55:27.557+00:00",[],"Dietary-Alteration-of-the-Gut-Microbiome-and-Its-Impact-on-Weight-and-Fat-Mass-A-Systematic-Review-and-Meta-Analysis",{"mag":5880,"pmc":5882,"openalex":5884,"abstract":5886,"title":5888,"pm":5890,"doi":5892},{"VOID":5881},"2790194570",{"VOID":5883},"5867888",{"VOID":5885},"W2790194570",{"EN":5887},"\u003Cjats:p>Dietary alteration of the gut microbiome is an important target in the treatment of obesity. Animal and human studies have shown bidirectional weight modulation based on the probiotic formulation used. In this study, we systematically reviewed the literature and performed a meta-analysis to assess the impact of prebiotics, probiotics and synbiotics on body weight, body mass index (BMI) and fat mass in adult human subjects. We searched Medline (PubMed), Embase, the Cochrane Library and the Web of Science to identify 4721 articles, of which 41 were subjected to full-text screening, yielding 21 included studies with 33 study arms. Probiotic use was associated with significant decreases in BMI, weight and fat mass. Studies of subjects consuming prebiotics demonstrated a significant reduction in body weight, whereas synbiotics did not show an effect. Overall, when the utilization of gut microbiome-modulating dietary agents (prebiotic\u002Fprobiotic\u002Fsynbiotic) was compared to placebo, there were significant decreases in BMI, weight and fat mass. In summary, dietary agents for the modulation of the gut microbiome are essential tools in the treatment of obesity and can lead to significant decreases in BMI, weight and fat mass. Further studies are needed to identify the ideal dose and duration of supplementation and to assess the durability of this effect.\u003C\u002Fjats:p>",{"EN":5889},"Dietary Alteration of the Gut Microbiome and Its Impact on Weight and Fat Mass: A Systematic Review and Meta-Analysis",{"VOID":5891},"29547587",{"VOID":5893},"10.3390\u002Fgenes9030167",[125],"https:\u002F\u002Fwww.mdpi.com\u002F2073-4425\u002F9\u002F3\u002F167",[5897,5916,5935,5952,5969,5986],{"id":5898,"sortIndex":22,"researcher":21,"roles":5899,"affiliations":5900,"properties":5909,"displayName":5913,"givenName":21,"familyName":21},"3d4af78b-c7e2-43de-a9b7-500f4ae3c15b",[],[5901],{"id":5902,"sortIndex":22,"affiliation":5903,"properties":21},"26ec0a33-f16b-44f8-8549-5001b6f13d9a",{"id":5902,"createTime":21,"updateTime":21,"relativeEntities":5904,"slug":21,"properties":5905,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":5908,"statistic":21},[],{"title":5906},{"VI":5907},"Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA",[],{"orcid":5910,"title":5912,"openalex":5914},{"VOID":5911},"https:\u002F\u002Forcid.org\u002F0000-0002-0595-5434",{"EN":5913},"George Kunnackal John",{"VOID":5915},"A5091750704",{"id":5917,"sortIndex":93,"researcher":21,"roles":5918,"affiliations":5919,"properties":5928,"displayName":5932,"givenName":21,"familyName":21},"683c8df2-e0f1-4654-a556-d0f4d2376b7f",[],[5920],{"id":5921,"sortIndex":22,"affiliation":5922,"properties":21},"ac4693e1-5a74-4fd6-b3a2-7444515d1fd8",{"id":5921,"createTime":21,"updateTime":21,"relativeEntities":5923,"slug":21,"properties":5924,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":5927,"statistic":21},[],{"title":5925},{"EN":5926},"Johns Hopkins School of Public Health, Baltimore, MD 21205, USA",[],{"orcid":5929,"title":5931,"openalex":5933},{"VOID":5930},"https:\u002F\u002Forcid.org\u002F0000-0003-2046-4366",{"EN":5932},"Lin Wang",{"VOID":5934},"A5100649560",{"id":5936,"sortIndex":214,"researcher":21,"roles":5937,"affiliations":5938,"properties":5945,"displayName":5949,"givenName":21,"familyName":21},"4ea4067c-59f2-4170-a8ab-4d8fc414450e",[],[5939],{"id":5902,"sortIndex":22,"affiliation":5940,"properties":21},{"id":5902,"createTime":21,"updateTime":21,"relativeEntities":5941,"slug":21,"properties":5942,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":5944,"statistic":21},[],{"title":5943},{"VI":5907},[],{"orcid":5946,"title":5948,"openalex":5950},{"VOID":5947},"https:\u002F\u002Forcid.org\u002F0000-0002-8356-0278",{"EN":5949},"Julie Nanavati",{"VOID":5951},"A5031870708",{"id":5953,"sortIndex":134,"researcher":21,"roles":5954,"affiliations":5955,"properties":5962,"displayName":5966,"givenName":21,"familyName":21},"3d2650d4-7090-4dbd-b88b-be5972d072f1",[],[5956],{"id":5902,"sortIndex":22,"affiliation":5957,"properties":21},{"id":5902,"createTime":21,"updateTime":21,"relativeEntities":5958,"slug":21,"properties":5959,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":5961,"statistic":21},[],{"title":5960},{"VI":5907},[],{"orcid":5963,"title":5965,"openalex":5967},{"VOID":5964},"https:\u002F\u002Forcid.org\u002F0000-0001-9667-076X",{"EN":5966},"Claire Twose",{"VOID":5968},"A5004309615",{"id":5970,"sortIndex":137,"researcher":21,"roles":5971,"affiliations":5972,"properties":5981,"displayName":5983,"givenName":21,"familyName":21},"744cabd6-f987-4890-9793-71f118619c4b",[],[5973],{"id":5974,"sortIndex":22,"affiliation":5975,"properties":21},"70914bc1-db6b-49b7-bb77-cc6525179884",{"id":5974,"createTime":21,"updateTime":21,"relativeEntities":5976,"slug":21,"properties":5977,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":5980,"statistic":21},[],{"title":5978},{"VI":5979},"Sinai Hospital, Baltimore, MD 21215 USA",[],{"title":5982,"openalex":5984},{"EN":5983},"Rajdeep Singh",{"VOID":5985},"A5015046118",{"id":5987,"sortIndex":138,"researcher":21,"roles":5988,"affiliations":5989,"properties":5996,"displayName":6000,"givenName":21,"familyName":21},"18a09a95-b991-4c86-b82f-1850b19f1f8b",[],[5990],{"id":5902,"sortIndex":22,"affiliation":5991,"properties":21},{"id":5902,"createTime":21,"updateTime":21,"relativeEntities":5992,"slug":21,"properties":5993,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":5995,"statistic":21},[],{"title":5994},{"VI":5907},[],{"orcid":5997,"title":5999,"openalex":6001},{"VOID":5998},"https:\u002F\u002Forcid.org\u002F0000-0001-5317-6788",{"EN":6000},"Gerard E. 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BMI Classification. Available online: http:\u002F\u002Fapps.who.int\u002Fbmi\u002Findex.jsp?introPage=intro_3.htm.",{},{"id":21,"text":6066,"url":21,"identifiers":6067},"Kivimaki, 2017, Overweight, obesity, and risk of cardiometabolic multimorbidity: Pooled analysis of individual-level data for 120,813 adults from 16 cohort studies from the USA and Europe, Lancet Public Health, 2, e277, 10.1016\u002FS2468-2667(17)30074-9",{"doi":6068},"10.1016\u002FS2468-2667(17)30074-9",{"id":21,"text":6070,"url":21,"identifiers":6071},"McMillan, 2006, Obesity and cancer, BMJ, 333, 1109, 10.1136\u002Fbmj.39042.565035.BE1",{"doi":6072},"10.1136\u002Fbmj.39042.565035.BE1",{"id":21,"text":6074,"url":21,"identifiers":6075},"Reilly, 2005, Early life risk factors for obesity in childhood: Cohort study, BMJ, 330, 1357, 10.1136\u002Fbmj.38470.670903.E0",{"doi":6076},"10.1136\u002Fbmj.38470.670903.E0",{"id":21,"text":6078,"url":21,"identifiers":6079},"Baquero, 2012, The microbiome as a human organ, Clin. Microbiol. Infect., 18, 2, 10.1111\u002Fj.1469-0691.2012.03916.x",{"doi":6080},"10.1111\u002Fj.1469-0691.2012.03916.x",{"id":21,"text":6082,"url":21,"identifiers":6083},"Okeke, 2014, The role of the gut microbiome in the pathogenesis and treatment of obesity, Glob. Adv. Health Med., 3, 44, 10.7453\u002Fgahmj.2014.018",{"doi":6084},"10.7453\u002Fgahmj.2014.018",{"id":21,"text":6086,"url":21,"identifiers":6087},"Flint, 1998, Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans, J. Clin. Investig., 101, 515, 10.1172\u002FJCI990",{"doi":6088},"10.1172\u002FJCI990",{"id":21,"text":6090,"url":21,"identifiers":6091},"Vinolo, 2011, Regulation of inflammation by short chain fatty acids, Nutrients, 3, 858, 10.3390\u002Fnu3100858",{"doi":6092},"10.3390\u002Fnu3100858",{"id":21,"text":6094,"url":21,"identifiers":6095},"Margolles, 2016, Intestinal short chain fatty acids and their link with diet and human health, Front. Microbiol., 7, 185",{},{"id":21,"text":6097,"url":21,"identifiers":6098},"Mandard, 2006, The fasting-induced adipose factor\u002Fangiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity, J. Biol. Chem., 281, 934, 10.1074\u002Fjbc.M506519200",{"doi":6099},"10.1074\u002Fjbc.M506519200",{"id":21,"text":6101,"url":21,"identifiers":6102},"Planer, 2016, Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice, Nature, 534, 263, 10.1038\u002Fnature17940",{"doi":6103},"10.1038\u002Fnature17940",{"id":21,"text":6105,"url":21,"identifiers":6106},"Everard, 2013, Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity, Proc. Natl. Acad. Sci. USA, 110, 9066, 10.1073\u002Fpnas.1219451110",{"doi":6107},"10.1073\u002Fpnas.1219451110",{"id":21,"text":6109,"url":21,"identifiers":6110},"Dao, 2016, Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: Relationship with gut microbiome richness and ecology, Gut, 65, 426, 10.1136\u002Fgutjnl-2014-308778",{"doi":6111},"10.1136\u002Fgutjnl-2014-308778",{"id":21,"text":6113,"url":21,"identifiers":6114},"Ding, 2004, The gut microbiota as an environmental factor that regulates fat storage, Proc. Natl. Acad. Sci. USA, 101, 15718, 10.1073\u002Fpnas.0407076101",{"doi":6115},"10.1073\u002Fpnas.0407076101",{"id":21,"text":6117,"url":21,"identifiers":6118},"Nieuwdorp, 2014, Role of the microbiome in energy regulation and metabolism, Gastroenterology, 146, 1525, 10.1053\u002Fj.gastro.2014.02.008",{"doi":6119},"10.1053\u002Fj.gastro.2014.02.008",{"id":21,"text":6121,"url":21,"identifiers":6122},"Turnbaugh, 2006, An obesity-associated gut microbiome with increased capacity for energy harvest, Nature, 444, 1027, 10.1038\u002Fnature05414",{"doi":6123},"10.1038\u002Fnature05414",{"id":21,"text":6125,"url":21,"identifiers":6126},"Ley, 2005, Obesity alters gut microbial ecology, Proc. Natl. Acad. Sci. USA, 102, 11070, 10.1073\u002Fpnas.0504978102",{"doi":6127},"10.1073\u002Fpnas.0504978102",{"id":21,"text":6129,"url":21,"identifiers":6130},"Groen, 2013, The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism, J. Lipid Res., 54, 2325, 10.1194\u002Fjlr.R036012",{"doi":6131},"10.1194\u002Fjlr.R036012",{"id":21,"text":6133,"url":21,"identifiers":6134},"John, 2016, The gut microbiome and obesity, Curr. Oncol. Rep., 18, 45, 10.1007\u002Fs11912-016-0528-7",{"doi":6135},"10.1007\u002Fs11912-016-0528-7",{"id":21,"text":6137,"url":21,"identifiers":6138},"Ley, 2010, Obesity and the human microbiome, Curr. Opin. Gastroenterol., 26, 5, 10.1097\u002FMOG.0b013e328333d751",{"doi":6139},"10.1097\u002FMOG.0b013e328333d751",{"id":21,"text":6141,"url":21,"identifiers":6142},"Turnbaugh, 2009, A core gut microbiome in obese and lean twins, Nature, 457, 480, 10.1038\u002Fnature07540",{"doi":6143},"10.1038\u002Fnature07540",{"id":21,"text":6145,"url":21,"identifiers":6146},"Park, 2015, Probiotics for weight loss: A systematic review and meta-analysis, Nutr. Res., 35, 566, 10.1016\u002Fj.nutres.2015.05.008",{"doi":6147},"10.1016\u002Fj.nutres.2015.05.008",{"id":21,"text":6149,"url":21,"identifiers":6150},"Dahiya, 2017, Gut microbiota modulation and its relationship with obesity using prebiotic fibers and probiotics: A review, Front. Microbiol., 8, 563, 10.3389\u002Ffmicb.2017.00563",{"doi":6151},"10.3389\u002Ffmicb.2017.00563",{"id":21,"text":6153,"url":21,"identifiers":6154},"Zhang, 2015, Effect of probiotics on body weight and body-mass index: A systematic review and meta-analysis of randomized, controlled trials, Int. J. Food Sci. Nutr., 67, 571, 10.1080\u002F09637486.2016.1181156",{"doi":6155},"10.1080\u002F09637486.2016.1181156",{"id":21,"text":6157,"url":21,"identifiers":6158},"Dror, 2017, Microbiota manipulation for weight change, Microb. Pathog., 106, 146, 10.1016\u002Fj.micpath.2016.01.002",{"doi":6159},"10.1016\u002Fj.micpath.2016.01.002",{"id":21,"text":6161,"url":21,"identifiers":6162},"Brahe, 2016, Can we prevent obesity-related metabolic diseases by dietary modulation of the gut microbiota?, Adv. Nutr., 7, 90, 10.3945\u002Fan.115.010587",{"doi":6163},"10.3945\u002Fan.115.010587",{"id":21,"text":6165,"url":21,"identifiers":6166},"Pineiro, 2008, FAO Technical Meeting on Prebiotics, J. Clin. Gastroenterol., 42, S156, 10.1097\u002FMCG.0b013e31817f184e",{"doi":6167},"10.1097\u002FMCG.0b013e31817f184e",{"id":21,"text":6169,"url":21,"identifiers":6170},"Rowland, 2010, Current level of consensus on probiotic science-Report of an expert meeting—London, 23 November 2009, Gut Microbes, 1, 436, 10.4161\u002Fgmic.1.6.13610",{"doi":6171},"10.4161\u002Fgmic.1.6.13610",{"id":21,"text":6173,"url":21,"identifiers":6174},"Million, 2012, Comparative meta-analysis of the effect of Lactobacillus species on weight gain in humans and animals, Microb. Pathog., 53, 100, 10.1016\u002Fj.micpath.2012.05.007",{"doi":6175},"10.1016\u002Fj.micpath.2012.05.007",{"id":21,"text":6177,"url":21,"identifiers":6178},"Kellow, 2014, Metabolic benefits of dietary prebiotics in human subjects: A systematic review of randomised controlled trials, Br. J. Nutr., 111, 1147, 10.1017\u002FS0007114513003607",{"doi":6179},"10.1017\u002FS0007114513003607",{"id":21,"text":6181,"url":21,"identifiers":6182},"Mullin, G., John, G., Singh, R., Nanavati, J., and Alammar, N. (2017, December 05). Dietary alteration of the gut microbiome and its impact on weight: A systematic review and meta-analysis. Available online: http:\u002F\u002Fwww.crd.york.ac.uk\u002FPROSPERO\u002Fdisplay_record.php?ID=CRD42017075883.",{},{"id":21,"text":6184,"url":21,"identifiers":6185},"Medline (PubMed) (2018, March 15). National Library of Medicine, Available online: https:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpubmed\u002F.",{},{"id":21,"text":6187,"url":21,"identifiers":6188},"Elsevier (2018, March 15). Embase. Available online: https:\u002F\u002Fwww.elsevier.com\u002Fsolutions\u002Fembase-biomedical-research.",{},{"id":21,"text":6190,"url":21,"identifiers":6191},"Clarivate Analytics (2018, March 15). Web of Science. Available online: http:\u002F\u002Fwww.webofknowledge.com.",{},{"id":21,"text":6193,"url":21,"identifiers":6194},"Higgins, 2011, The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials, BMJ, 343, d5928, 10.1136\u002Fbmj.d5928",{"doi":6195},"10.1136\u002Fbmj.d5928",{"id":21,"text":6197,"url":21,"identifiers":6198},"Higgins, J.P.T., and Green, S. (2011). Cochrane Handbook for Systematic Reviews of Interventions, John Wiley & Sons.",{},{"id":21,"text":6200,"url":21,"identifiers":6201},"Fu, R., Vandermeer, B.W., Shamliyan, T.A., O’Neil, M.E., Yazdi, F., Fox, S.H., and Morton, S.C. (2008). AHRQ methods for effective health carehandling continuous outcomes in quantitative synthesis, Methods Guide for Effectiveness and Comparative Effectiveness Reviews.",{},{"id":21,"text":6203,"url":21,"identifiers":6204},"Fernandes, 2016, Effects of prebiotic and synbiotic supplementation on inflammatory markers and anthropometric indices after Roux-en-Y gastric bypass: A randomized, triple-blind, placebo-controlled pilot study, J. Clin. Gastroenterol., 50, 208, 10.1097\u002FMCG.0000000000000328",{"doi":6205},"10.1097\u002FMCG.0000000000000328",{"id":21,"text":6207,"url":21,"identifiers":6208},"Asemi, 2013, Effect of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in patients with Type 2 diabetes, Ann. Nutr. Metab., 63, 1, 10.1159\u002F000349922",{"doi":6209},"10.1159\u002F000349922",{"id":21,"text":6211,"url":21,"identifiers":6212},"Canfora, 2017, Supplementation of diet with galacto-oligosaccharides increases bifidobacteria, but not insulin sensitivity, in obese prediabetic individuals, J. Pharm. Pharmacol., 153, 87",{},{"id":21,"text":6214,"url":21,"identifiers":6215},"Gomes, 2017, The additional effects of a probiotic mix on abdominal adiposity and antioxidant status: A double-blind, randomized trial, Obesity, 25, 30, 10.1002\u002Foby.21671",{"doi":6216},"10.1002\u002Foby.21671",{"id":21,"text":6218,"url":21,"identifiers":6219},"Higashikawa, 2016, Antiobesity effect of Pediococcus pentosaceus LP28 on overweight subjects: A randomized, double-blind, placebo-controlled clinical trial, Eur. J. Clin. Nutr., 70, 582, 10.1038\u002Fejcn.2016.17",{"doi":6220},"10.1038\u002Fejcn.2016.17",{"id":21,"text":6222,"url":21,"identifiers":6223},"Javadi, 2017, The potential role of probiotics or\u002Fand prebiotic on serum lipid profile and insulin resistance in alcoholic fatty liver disease: A double blind randomized clinical trial, Crescent J. Med. Biol. Sci., 4, 131",{},{"id":21,"text":6225,"url":21,"identifiers":6226},"Jung, 2015, Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduced body adiposity and Lp-PLA(2) activity in overweight subjects, J. Funct. Foods, 19, 744, 10.1016\u002Fj.jff.2015.10.006",{"doi":6227},"10.1016\u002Fj.jff.2015.10.006",{"id":21,"text":6229,"url":21,"identifiers":6230},"Jung, 2013, Effect of Lactobacillus gasseri BNR17 on overweight and obese adults: A randomized, double-blind clinical trial, Korean J. Fam. Med., 34, 80, 10.4082\u002Fkjfm.2013.34.2.80",{"doi":6231},"10.4082\u002Fkjfm.2013.34.2.80",{"id":21,"text":6233,"url":21,"identifiers":6234},"Kadooka, 2010, Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial, Eur. J. Clin. Nutr., 64, 636, 10.1038\u002Fejcn.2010.19",{"doi":6235},"10.1038\u002Fejcn.2010.19",{"id":21,"text":6237,"url":21,"identifiers":6238},"Kadooka, 2013, Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomised controlled trial, Br. J. Nutr., 110, 1696, 10.1017\u002FS0007114513001037",{"doi":6239},"10.1017\u002FS0007114513001037",{"id":21,"text":6241,"url":21,"identifiers":6242},"Kim, 2017, Effects of weight loss using supplementation with Lactobacillus strains on body fat and medium-chain acylcarnitines in overweight individuals, Food Funct., 8, 250, 10.1039\u002FC6FO00993J",{"doi":6243},"10.1039\u002FC6FO00993J",{"id":21,"text":6245,"url":21,"identifiers":6246},"Lambert, 2017, Consuming yellow pea fiber reduces voluntary energy intake and body fat in overweight\u002Fobese adults in a 12-week randomized controlled trial, Clin. Nutr., 36, 126, 10.1016\u002Fj.clnu.2015.12.016",{"doi":6247},"10.1016\u002Fj.clnu.2015.12.016",{"id":21,"text":6249,"url":21,"identifiers":6250},"Leber, 2012, The influence of probiotic supplementation on gut permeability in patients with metabolic syndrome: An open label, randomized pilot study, Eur. J. Clin. Nutr., 66, 1110, 10.1038\u002Fejcn.2012.103",{"doi":6251},"10.1038\u002Fejcn.2012.103",{"id":21,"text":6253,"url":21,"identifiers":6254},"Madjd, 2016, Comparison of the effect of daily consumption of probiotic compared with low-fat conventional yogurt on weight loss in healthy obese women following an energy-restricted diet: A randomized controlled trial, Am. J. Clin. Nutr., 103, 323, 10.3945\u002Fajcn.115.120170",{"doi":6255},"10.3945\u002Fajcn.115.120170",{"id":21,"text":6257,"url":21,"identifiers":6258},"Minami, 2015, Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomised controlled trial, J. Nutr. Sci., 4, e17, 10.1017\u002Fjns.2015.5",{"doi":6259},"10.1017\u002Fjns.2015.5",{"id":21,"text":6261,"url":21,"identifiers":6262},"Rabiei, 2015, The effects of symbiotic therapy on anthropometric measures, body composition and blood pressure in patient with metabolic syndrome: A triple blind RCT, Med. J. Islam. Repub. Iran, 29, 213",{},{"id":21,"text":6264,"url":21,"identifiers":6265},"Reimer, R.A., Willis, H.J., Tunnicliffe, J.M., Park, H., Madsen, K.L., and Soto-Vaca, A. (2017). Inulin-type fructans and whey protein both modulate appetite but only fructans alter gut microbiota in adults with overweight\u002Fobesity: A randomized controlled trial. Mol. Nutr. Food Res., 61.",{"doi":6266},"10.1002\u002Fmnfr.201700484",{"id":21,"text":6268,"url":21,"identifiers":6269},"Sanchez, 2013, Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women, Can. J. Diabetes, 37, S269, 10.1016\u002Fj.jcjd.2013.03.270",{"doi":6270},"10.1016\u002Fj.jcjd.2013.03.270",{"id":21,"text":6272,"url":21,"identifiers":6273},"Sharafedtinov, 2013, Hypocaloric diet supplemented with probiotic cheese improves body mass index and blood pressure indices of obese hypertensive patients—A randomized double-blind placebo-controlled pilot study, Nutr. J., 12, 138, 10.1186\u002F1475-2891-12-138",{"doi":6274},"10.1186\u002F1475-2891-12-138",{"id":21,"text":6276,"url":21,"identifiers":6277},"Stenman, 2016, Probiotic with or without fiber controls body fat mass, associated with serum zonulin, in overweight and obese adults-randomized controlled trial, PLoS ONE, 13, 190",{},{"id":21,"text":6279,"url":21,"identifiers":6280},"Zarrati, 2014, Effects of probiotic yogurt on fat distribution and gene expression of proinflammatory factors in peripheral blood mononuclear cells in overweight and obese people with or without weight-loss diet, J. Am. Coll. Nutr., 33, 417, 10.1080\u002F07315724.2013.874937",{"doi":6281},"10.1080\u002F07315724.2013.874937",{"id":21,"text":6283,"url":21,"identifiers":6284},"Jones, S.E., and Versalovic, J. (2009). Probiotic Lactobacillus reuteri biofilms produce antimicrobial and anti-inflammatory factors. BMC Microbiol., 9.",{"doi":6285},"10.1186\u002F1471-2180-9-35",{"id":21,"text":6287,"url":21,"identifiers":6288},"Madsen, 2001, Probiotic bacteria enhance murine and human intestinal epithelial barrier function, Gastroenterology, 121, 580, 10.1053\u002Fgast.2001.27224",{"doi":6289},"10.1053\u002Fgast.2001.27224",{"id":21,"text":6291,"url":21,"identifiers":6292},"He, 2017, Gut microbiota as a potential target of metabolic syndrome: The role of probiotics and prebiotics, Cell Biosci., 7, 54, 10.1186\u002Fs13578-017-0183-1",{"doi":6293},"10.1186\u002Fs13578-017-0183-1",{"id":21,"text":6295,"url":21,"identifiers":6296},"Cani, 2007, Metabolic endotoxemia initiates obesity and insulin resistance, Diabetes, 56, 1761, 10.2337\u002Fdb06-1491",{"doi":6297},"10.2337\u002Fdb06-1491",{"id":21,"text":6299,"url":21,"identifiers":6300},"Begley, 2006, Bile salt hydrolase activity in probiotics, Appl. Environ. Microbiol., 72, 1729, 10.1128\u002FAEM.72.3.1729-1738.2006",{"doi":6301},"10.1128\u002FAEM.72.3.1729-1738.2006",{"id":21,"text":6303,"url":21,"identifiers":6304},"Topping, 2001, Short-chain fatty acids and human colonic function: Roles of resistant starch and nonstarch polysaccharides, Physiol. Rev., 81, 1031, 10.1152\u002Fphysrev.2001.81.3.1031",{"doi":6305},"10.1152\u002Fphysrev.2001.81.3.1031",{"id":21,"text":6307,"url":21,"identifiers":6308},"Willemsen, 2003, Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E(1) and E(2) production by intestinal myofibroblasts, Gut, 52, 1442, 10.1136\u002Fgut.52.10.1442",{"doi":6309},"10.1136\u002Fgut.52.10.1442",{"id":21,"text":6311,"url":21,"identifiers":6312},"Wong, 2006, Colonic health: Fermentation and short chain fatty acids, J. Clin. Gastroenterol., 40, 235, 10.1097\u002F00004836-200603000-00015",{"doi":6313},"10.1097\u002F00004836-200603000-00015",{"id":21,"text":6315,"url":21,"identifiers":6316},"Cani, 2008, Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice, Diabetes, 57, 1470, 10.2337\u002Fdb07-1403",{"doi":6317},"10.2337\u002Fdb07-1403",{"id":21,"text":6319,"url":21,"identifiers":6320},"Ley, 2006, Microbial ecology: Human gut microbes associated with obesity, Nature, 444, 1022, 10.1038\u002F4441022a",{"doi":6321},"10.1038\u002F4441022a",{"id":21,"text":6323,"url":21,"identifiers":6324},"Turnbaugh, 2008, Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome, Cell Host Microbe, 3, 213, 10.1016\u002Fj.chom.2008.02.015",{"doi":6325},"10.1016\u002Fj.chom.2008.02.015",{"id":21,"text":6327,"url":21,"identifiers":6328},"Million, 2013, The role of the manipulation of the gut microbiota in obesity, Curr. Infect. Dis. Rep., 15, 25, 10.1007\u002Fs11908-012-0301-5",{"doi":6329},"10.1007\u002Fs11908-012-0301-5",{"id":6331,"createTime":6332,"updateTime":6332,"relativeEntities":6333,"slug":6334,"properties":6335,"entityType":964,"verifyStatus":121,"verifyTime":6332,"verifyNote":1071,"languages":6350,"translateLanguages":21,"viewCount":22,"primaryUrl":6351,"fullTextUrl":21,"authors":6352,"publicationType":991,"publisherRelationship":6420,"citationCount":6472,"citationInfo":6473,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":6475,"openAccess":21,"references":6476,"isForceReanalyzing":1050},"41c0da1e-7739-41d5-990f-dd27e6fc399b","2024-09-19T07:07:05.473+00:00",[],"Blueprints-for-Biosensors-Design-Limitations-and-Applications",{"mag":6336,"pmc":6338,"openalex":6340,"abstract":6342,"title":6344,"pm":6346,"doi":6348},{"VOID":6337},"2884156626",{"VOID":6339},"6115959",{"VOID":6341},"W2884156626",{"EN":6343},"\u003Cjats:p>Biosensors are enabling major advances in the field of analytics that are both facilitating and being facilitated by advances in synthetic biology. The ability of biosensors to rapidly and specifically detect a wide range of molecules makes them highly relevant to a range of industrial, medical, ecological, and scientific applications. Approaches to biosensor design are as diverse as their applications, with major biosensor classes including nucleic acids, proteins, and transcription factors. Each of these biosensor types has advantages and limitations based on the intended application, and the parameters that are required for optimal performance. Specifically, the choice of biosensor design must consider factors such as the ligand specificity, sensitivity, dynamic range, functional range, mode of output, time of activation, ease of use, and ease of engineering. 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Eng., 42, 98, 10.1016\u002Fj.ymben.2017.06.003",{"doi":6484},"10.1016\u002Fj.ymben.2017.06.003",{"id":21,"text":6486,"url":21,"identifiers":6487},"Hughes, R.A., and Ellington, A.D. (2017). Synthetic DNA synthesis and assembly: Putting the synthetic in synthetic biology. Cold Spring Harb. Perspect. Biol., 9.",{"doi":6488},"10.1101\u002Fcshperspect.a023812",{"id":21,"text":6490,"url":21,"identifiers":6491},"Marcellin, 2018, Advances in analytical tools for high throughput strain engineering, Curr. Opin. Biotechnol., 54, 33, 10.1016\u002Fj.copbio.2018.01.027",{"doi":6492},"10.1016\u002Fj.copbio.2018.01.027",{"id":21,"text":6494,"url":21,"identifiers":6495},"Turner, 2013, Biosensors: Sense and sensibility, Chem. Soc. Rev., 42, 3184, 10.1039\u002Fc3cs35528d",{"doi":6496},"10.1039\u002Fc3cs35528d",{"id":21,"text":6498,"url":21,"identifiers":6499},"Tian, 2009, Imaging neural activity in worms, flies and mice with improved GAaMP calcium indicators, Nat. Methods, 6, 875, 10.1038\u002Fnmeth.1398",{"doi":6500},"10.1038\u002Fnmeth.1398",{"id":21,"text":6502,"url":21,"identifiers":6503},"Xiao, 2005, Label-free electronic detection of thrombin in blood serum by using an aptamer-based sensor, Angew. Chem. Int. Ed. Engl., 44, 5456, 10.1002\u002Fanie.200500989",{"doi":6504},"10.1002\u002Fanie.200500989",{"id":21,"text":6506,"url":21,"identifiers":6507},"Scognamiglio, 2014, Biosensing technology for sustainable food safety, TrAC Trends Anal. Chem., 62, 1, 10.1016\u002Fj.trac.2014.07.007",{"doi":6508},"10.1016\u002Fj.trac.2014.07.007",{"id":21,"text":6510,"url":21,"identifiers":6511},"Venugopal, 2002, Biosensors in fish production and quality control, Biosens. Bioelectron., 17, 147, 10.1016\u002FS0956-5663(01)00180-4",{"doi":6512},"10.1016\u002FS0956-5663(01)00180-4",{"id":21,"text":6514,"url":21,"identifiers":6515},"Verma, 2003, A disposable microbial based biosensor for quality control in milk, Biosens. Bioelectron., 18, 1219, 10.1016\u002FS0956-5663(03)00085-X",{"doi":6516},"10.1016\u002FS0956-5663(03)00085-X",{"id":21,"text":6518,"url":21,"identifiers":6519},"Hesari, N., Kıratlı Yılmazçoban, N., Elzein, M., Alum, A., and Abbaszadegan, M. (2017). A strategy to establish a quality assurance\u002Fquality control plan for the application of biosensors for the detection of E. Coli in water. Biosensors, 7.",{"doi":6520},"10.3390\u002Fbios7010003",{"id":21,"text":6522,"url":21,"identifiers":6523},"Orgel, 2008, Biosensor-based on-site explosives detection using aptamers as recognition elements, Anal. Bioanal. Chem., 391, 1793, 10.1007\u002Fs00216-008-2150-5",{"doi":6524},"10.1007\u002Fs00216-008-2150-5",{"id":21,"text":6526,"url":21,"identifiers":6527},"Dekker, 2017, Sense and sensitivity in bioprocessing—Detecting cellular metabolites with biosensors, Curr. Opin. Chem. Biol., 40, 31, 10.1016\u002Fj.cbpa.2017.05.014",{"doi":6528},"10.1016\u002Fj.cbpa.2017.05.014",{"id":21,"text":6530,"url":21,"identifiers":6531},"Biechele, 2015, Sensor systems for bioprocess monitoring, Eng. Life Sci., 15, 469, 10.1002\u002Felsc.201500014",{"doi":6532},"10.1002\u002Felsc.201500014",{"id":21,"text":6534,"url":21,"identifiers":6535},"Fang, 2015, Current and prospective methods for plant disease detection, Biosensors, 5, 537, 10.3390\u002Fbios5030537",{"doi":6536},"10.3390\u002Fbios5030537",{"id":21,"text":6538,"url":21,"identifiers":6539},"Ahn, 2004, Disposable smart lab on a chip for point-of-care clinical diagnostics, Proc. IEEE, 92, 154, 10.1109\u002FJPROC.2003.820548",{"doi":6540},"10.1109\u002FJPROC.2003.820548",{"id":21,"text":6542,"url":21,"identifiers":6543},"Soper, 2006, Point-of-care biosensor systems for cancer diagnostics\u002Fprognostics, Biosens. Bioelectron., 21, 1932, 10.1016\u002Fj.bios.2006.01.006",{"doi":6544},"10.1016\u002Fj.bios.2006.01.006",{"id":21,"text":6546,"url":21,"identifiers":6547},"Amano, 2005, Detection of influenza virus: Traditional approaches and development of biosensors, Anal. Bioanal. Chem., 381, 156, 10.1007\u002Fs00216-004-2927-0",{"doi":6548},"10.1007\u002Fs00216-004-2927-0",{"id":21,"text":6550,"url":21,"identifiers":6551},"Smith, 2008, A review of biosensors and biologically-inspired systems for explosives detection, Analyst, 133, 571, 10.1039\u002Fb717933m",{"doi":6552},"10.1039\u002Fb717933m",{"id":21,"text":6554,"url":21,"identifiers":6555},"Tegos, 2013, Biodefense: Trends and challenges in combating biological warfare agents, Virulence, 4, 740, 10.4161\u002Fviru.27170",{"doi":6556},"10.4161\u002Fviru.27170",{"id":21,"text":6558,"url":21,"identifiers":6559},"Klenkar, 2008, A microarray chip for label-free detection of narcotics, Anal. Bioanal. Chem., 391, 1679, 10.1007\u002Fs00216-008-1839-9",{"doi":6560},"10.1007\u002Fs00216-008-1839-9",{"id":21,"text":6562,"url":21,"identifiers":6563},"Zhang, 2015, Graphene oxide-based optical biosensor functionalized with peptides for explosive detection, Biosens. Bioelectron., 68, 494, 10.1016\u002Fj.bios.2015.01.040",{"doi":6564},"10.1016\u002Fj.bios.2015.01.040",{"id":21,"text":6566,"url":21,"identifiers":6567},"Klutz, 2016, Cost evaluation of antibody production processes in different operation modes, Chem. Eng. Sci., 141, 63, 10.1016\u002Fj.ces.2015.10.029",{"doi":6568},"10.1016\u002Fj.ces.2015.10.029",{"id":21,"text":6570,"url":21,"identifiers":6571},"Williams, 2016, Synthetic evolution of metabolic productivity using biosensors, Trends Biotechnol., 34, 371, 10.1016\u002Fj.tibtech.2016.02.002",{"doi":6572},"10.1016\u002Fj.tibtech.2016.02.002",{"id":21,"text":6574,"url":21,"identifiers":6575},"Mehrotra, 2016, Biosensors and their applications—A review, J. Oral Biol. Craniofac. Res., 6, 153, 10.1016\u002Fj.jobcr.2015.12.002",{"doi":6576},"10.1016\u002Fj.jobcr.2015.12.002",{"id":21,"text":6578,"url":21,"identifiers":6579},"Zhang, 2015, Development of biosensors and their application in metabolic engineering, Curr. Opin. Chem. Biol., 28, 1, 10.1016\u002Fj.cbpa.2015.05.013",{"doi":6580},"10.1016\u002Fj.cbpa.2015.05.013",{"id":21,"text":6582,"url":21,"identifiers":6583},"Kotula, 2014, Programmable bacteria detect and record an environmental signal in the mammalian gut, Proc. Natl. Acad. Sci. USA, 111, 4838, 10.1073\u002Fpnas.1321321111",{"doi":6584},"10.1073\u002Fpnas.1321321111",{"id":21,"text":6586,"url":21,"identifiers":6587},"Birkedal, 2015, Construction of a fuzzy and boolean logic gates based on DNA, Small, 11, 1811, 10.1002\u002Fsmll.201402755",{"doi":6588},"10.1002\u002Fsmll.201402755",{"id":21,"text":6590,"url":21,"identifiers":6591},"Casadaban, 1976, Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu, J. Mol. Biol., 104, 541, 10.1016\u002F0022-2836(76)90119-4",{"doi":6592},"10.1016\u002F0022-2836(76)90119-4",{"id":21,"text":6594,"url":21,"identifiers":6595},"Kenyon, 1980, DNA-damaging agents stimulate gene expression at specific loci in Escherichia coli, Proc. Natl. Acad. Sci. USA, 77, 2819, 10.1073\u002Fpnas.77.5.2819",{"doi":6596},"10.1073\u002Fpnas.77.5.2819",{"id":21,"text":6598,"url":21,"identifiers":6599},"Karig, 2017, Cell-free synthetic biology for environmental sensing and remediation, Curr. Opin. Biotechnol., 45, 69, 10.1016\u002Fj.copbio.2017.01.010",{"doi":6600},"10.1016\u002Fj.copbio.2017.01.010",{"id":21,"text":6602,"url":21,"identifiers":6603},"Pardee, 2014, Paper-based synthetic gene networks, Cell, 159, 940, 10.1016\u002Fj.cell.2014.10.004",{"doi":6604},"10.1016\u002Fj.cell.2014.10.004",{"id":21,"text":6606,"url":21,"identifiers":6607},"Jensen, 2017, Lighting up yeast cell factories by transcription factor-based biosensors, FEMS Yeast Res., 17, fox076",{},{"id":21,"text":6609,"url":21,"identifiers":6610},"Williams, 2017, Positive-feedback, ratiometric biosensor expression improves high-throughput metabolite-producer screening efficiency in yeast, Synth. Biol., 2, ysw002, 10.1093\u002Fsynbio\u002Fysw002",{"doi":6611},"10.1093\u002Fsynbio\u002Fysw002",{"id":21,"text":6613,"url":21,"identifiers":6614},"Siedler, 2014, SoxR as a single-cell biosensor for NADPH consuming enzymes in Escherichia coli, ACS Synth. Biol., 3, 41, 10.1021\u002Fsb400110j",{"doi":6615},"10.1021\u002Fsb400110j",{"id":21,"text":6617,"url":21,"identifiers":6618},"Zhang, 2016, Engineering an NADPH\u002FNADP+ redox biosensor in yeast, ACS Synth. Biol., 5, 1546, 10.1021\u002Facssynbio.6b00135",{"doi":6619},"10.1021\u002Facssynbio.6b00135",{"id":21,"text":6621,"url":21,"identifiers":6622},"Leavitt, J.M., Wagner, J.M., Tu, C.C., Tong, A., Liu, Y., and Alper, H.S. (2017). Biosensor-enabled directed evolution to improve muconic acid production in Saccharomyces cerevisiae. Biotechnol. J., 12.",{"doi":6623},"10.1002\u002Fbiot.201600687",{"id":21,"text":6625,"url":21,"identifiers":6626},"Zhang, 2012, Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids, Nat. Biotechnol., 30, 354, 10.1038\u002Fnbt.2149",{"doi":6627},"10.1038\u002Fnbt.2149",{"id":21,"text":6629,"url":21,"identifiers":6630},"Binder, 2012, A high-throughput approach to identify genomic variants of bacterial metabolite producers at the single-cell level, Genome Biol., 13, R40, 10.1186\u002Fgb-2012-13-5-r40",{"doi":6631},"10.1186\u002Fgb-2012-13-5-r40",{"id":21,"text":6633,"url":21,"identifiers":6634},"Seok, 2018, Directed evolution of the 3-hydroxypropionic acid production pathway by engineering aldehyde dehydrogenase using a synthetic selection device, Metab. Eng., 47, 113, 10.1016\u002Fj.ymben.2018.03.009",{"doi":6635},"10.1016\u002Fj.ymben.2018.03.009",{"id":21,"text":6637,"url":21,"identifiers":6638},"Mahr, 2015, Biosensor-driven adaptive laboratory evolution of l-valine production in Corynebacterium glutamicum, Metab. Eng., 32, 184, 10.1016\u002Fj.ymben.2015.09.017",{"doi":6639},"10.1016\u002Fj.ymben.2015.09.017",{"id":21,"text":6641,"url":21,"identifiers":6642},"Johnson, 2017, Design and application of genetically-encoded malonyl-CoAa biosensors for metabolic engineering of microbial cell factories, Metab. Eng., 44, 253, 10.1016\u002Fj.ymben.2017.10.011",{"doi":6643},"10.1016\u002Fj.ymben.2017.10.011",{"id":21,"text":6645,"url":21,"identifiers":6646},"Kasey, 2018, Development of transcription factor-based designer macrolide biosensors for metabolic engineering and synthetic biology, ACS Synth. Biol., 7, 227, 10.1021\u002Facssynbio.7b00287",{"doi":6647},"10.1021\u002Facssynbio.7b00287",{"id":21,"text":6649,"url":21,"identifiers":6650},"Chen, 2018, Engineering tunable biosensors for monitoring putrescine in Escherichia coli, Biotechnol. Bioeng., 115, 1014, 10.1002\u002Fbit.26521",{"doi":6651},"10.1002\u002Fbit.26521",{"id":21,"text":6653,"url":21,"identifiers":6654},"Ruiz, 2015, Transcription factor-based biosensors enlightened by the analyte, Front. Microbiol., 6, 648",{},{"id":21,"text":6656,"url":21,"identifiers":6657},"Gallegos, 1997, Arac\u002FXylS family of transcriptional regulators, Microbiol. Mol. Biol. Rev., 61, 393",{},{"id":21,"text":6659,"url":21,"identifiers":6660},"Ramos, 2005, The TetR family of transcriptional repressors, Microbiol. Mol. Biol. Rev., 69, 326, 10.1128\u002FMMBR.69.2.326-356.2005",{"doi":6661},"10.1128\u002FMMBR.69.2.326-356.2005",{"id":21,"text":6663,"url":21,"identifiers":6664},"Shi, 2017, Discovery and engineering of a 1-butanol biosensor in Saccharomyces cerevisiae, Bioresour. Technol., 245, 1343, 10.1016\u002Fj.biortech.2017.06.114",{"doi":6665},"10.1016\u002Fj.biortech.2017.06.114",{"id":21,"text":6667,"url":21,"identifiers":6668},"Dahl, 2013, Engineering dynamic pathway regulation using stress-response promoters, Nat. Biotechnol., 31, 1039, 10.1038\u002Fnbt.2689",{"doi":6669},"10.1038\u002Fnbt.2689",{"id":21,"text":6671,"url":21,"identifiers":6672},"Dietrich, 2013, Transcription factor-based screens and synthetic selections for microbial small-molecule biosynthesis, ACS Synth. Biol., 2, 47, 10.1021\u002Fsb300091d",{"doi":6673},"10.1021\u002Fsb300091d",{"id":21,"text":6675,"url":21,"identifiers":6676},"Kurth, 2008, Involvement of BmoR and BmoG in n-alkane metabolism in Ppseudomonas butanovora, Microbiology, 154, 139, 10.1099\u002Fmic.0.2007\u002F012724-0",{"doi":6677},"10.1099\u002Fmic.0.2007\u002F012724-0",{"id":21,"text":6679,"url":21,"identifiers":6680},"Wang, 2016, Design and engineering of intracellular-metabolite-sensing\u002Fregulation gene circuits in Saccharomyces cerevisiae, Biotechnol. Bioeng., 113, 206, 10.1002\u002Fbit.25676",{"doi":6681},"10.1002\u002Fbit.25676",{"id":21,"text":6683,"url":21,"identifiers":6684},"Lutz, 1997, Independent and tight regulation of transcriptional units in Escherichia coli via the LacR\u002FO, the TetR\u002FO and AraC\u002FI1-I2 regulatory elements, Nucleic Acids Res., 25, 1203, 10.1093\u002Fnar\u002F25.6.1203",{"doi":6685},"10.1093\u002Fnar\u002F25.6.1203",{"id":21,"text":6687,"url":21,"identifiers":6688},"Chou, 2013, Programming adaptive control to evolve increased metabolite production, Nat. Commun., 4, 2595, 10.1038\u002Fncomms3595",{"doi":6689},"10.1038\u002Fncomms3595",{"id":21,"text":6691,"url":21,"identifiers":6692},"Cherf, 2015, Applications of yeast surface display for protein engineering, Methods Mol. Biol., 1319, 155, 10.1007\u002F978-1-4939-2748-7_8",{"doi":6693},"10.1007\u002F978-1-4939-2748-7_8",{"id":21,"text":6695,"url":21,"identifiers":6696},"Pande, 2010, Phage display: Concept, innovations, applications and future, Biotechnol. Adv., 28, 849, 10.1016\u002Fj.biotechadv.2010.07.004",{"doi":6697},"10.1016\u002Fj.biotechadv.2010.07.004",{"id":21,"text":6699,"url":21,"identifiers":6700},"Belkin, 2010, Where microbiology meets microengineering: Design and applications of reporter bacteria, Nat. Rev. Microbiol., 8, 511, 10.1038\u002Fnrmicro2392",{"doi":6701},"10.1038\u002Fnrmicro2392",{"id":21,"text":6703,"url":21,"identifiers":6704},"Polizzi, 2015, Genetically-encoded biosensors for monitoring cellular stress in bioprocessing, Curr. Opin. Biotechnol., 31, 50, 10.1016\u002Fj.copbio.2014.07.011",{"doi":6705},"10.1016\u002Fj.copbio.2014.07.011",{"id":21,"text":6707,"url":21,"identifiers":6708},"Mahr, 2016, Transcription factor-based biosensors in biotechnology: Current state and future prospects, Appl. Microbiol. Biotechnol., 100, 79, 10.1007\u002Fs00253-015-7090-3",{"doi":6709},"10.1007\u002Fs00253-015-7090-3",{"id":21,"text":6711,"url":21,"identifiers":6712},"Rogers, 2016, Biosensor-based engineering of biosynthetic pathways, Curr. Opin. Biotechnol., 42, 84, 10.1016\u002Fj.copbio.2016.03.005",{"doi":6713},"10.1016\u002Fj.copbio.2016.03.005",{"id":21,"text":6715,"url":21,"identifiers":6716},"Tuerk, 1990, Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase, Science, 249, 505, 10.1126\u002Fscience.2200121",{"doi":6717},"10.1126\u002Fscience.2200121",{"id":21,"text":6719,"url":21,"identifiers":6720},"Ellington, 1990, In Vitro selection of RNA molecules that bind specific ligands, Nature, 346, 818, 10.1038\u002F346818a0",{"doi":6721},"10.1038\u002F346818a0",{"id":21,"text":6723,"url":21,"identifiers":6724},"Ellington, 1992, Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures, Nature, 355, 850, 10.1038\u002F355850a0",{"doi":6725},"10.1038\u002F355850a0",{"id":21,"text":6727,"url":21,"identifiers":6728},"Song, 2008, Aptamer-based biosensors, TrAC Trends Anal. Chem., 27, 108, 10.1016\u002Fj.trac.2007.12.004",{"doi":6729},"10.1016\u002Fj.trac.2007.12.004",{"id":21,"text":6731,"url":21,"identifiers":6732},"McKeague, M., Velu, R., Hill, K., Bardóczy, V., Mészáros, T., and DeRosa, M. (2014). Selection and characterization of a novel DNA aptamer for label-free fluorescence biosensing of Ochratoxin A. Toxins, 6.",{"doi":6733},"10.3390\u002Ftoxins6082435",{"id":21,"text":6735,"url":21,"identifiers":6736},"Yingfu, L., and Yi, L. (2009). Artificial functional nucleic acids: Aptamers, ribozymes, and deoxyribozymes identified by in vitro selection. Functional Nucleic Acids for Analytical Applications, Springer.",{"doi":6737},"10.1007\u002F978-0-387-73711-9",{"id":21,"text":6739,"url":21,"identifiers":6740},"McKeague, 2012, Challenges and opportunities for small molecule aptamer development, J. Nucleic Acids, 2012, 20, 10.1155\u002F2012\u002F748913",{"doi":6741},"10.1155\u002F2012\u002F748913",{"id":21,"text":6743,"url":21,"identifiers":6744},"Sefah, 2010, Development of DNA aptamers using cell-selex, Nat. Protoc., 5, 1169, 10.1038\u002Fnprot.2010.66",{"doi":6745},"10.1038\u002Fnprot.2010.66",{"id":21,"text":6747,"url":21,"identifiers":6748},"Ruscito, A., and DeRosa, M.C. (2016). Small-molecule binding aptamers: Selection strategies, characterization, and applications. Front. Chem., 4.",{"doi":6749},"10.3389\u002Ffchem.2016.00014",{"id":21,"text":6751,"url":21,"identifiers":6752},"Michener, 2012, Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways, Metab. Eng., 14, 212, 10.1016\u002Fj.ymben.2011.09.004",{"doi":6753},"10.1016\u002Fj.ymben.2011.09.004",{"id":21,"text":6755,"url":21,"identifiers":6756},"Gong, S., Wang, Y., Wang, Z., and Zhang, W. (2017). Computational methods for modeling aptamers and designing riboswitches. Int. J. Mol. Sci., 18.",{"doi":6757},"10.3390\u002Fijms18112442",{"id":21,"text":6759,"url":21,"identifiers":6760},"McKeague, 2015, Comprehensive analytical comparison of strategies used for small molecule aptamer evaluation, Anal. Chem., 87, 8608, 10.1021\u002Facs.analchem.5b02102",{"doi":6761},"10.1021\u002Facs.analchem.5b02102",{"id":21,"text":6763,"url":21,"identifiers":6764},"Alsaafin, 2017, Functional nucleic acids as in vivo metabolite and ion biosensors, Biosens. Bioelectron., 94, 94, 10.1016\u002Fj.bios.2017.02.030",{"doi":6765},"10.1016\u002Fj.bios.2017.02.030",{"id":21,"text":6767,"url":21,"identifiers":6768},"Findeiss, S., Etzel, M., Will, S., Morl, M., and Stadler, P.F. (2017). Design of artificial riboswitches as biosensors. Sensors, 17.",{"doi":6769},"10.3390\u002Fs17091990",{"id":21,"text":6771,"url":21,"identifiers":6772},"Hejazi, 2016, Riboswitches: From living biosensors to novel targets of antibiotics, Gene, 592, 244, 10.1016\u002Fj.gene.2016.07.035",{"doi":6773},"10.1016\u002Fj.gene.2016.07.035",{"id":21,"text":6775,"url":21,"identifiers":6776},"Machtel, 2016, Emerging applications of riboswitches—from antibacterial targets to molecular tools, J. Appl. Genet., 57, 531, 10.1007\u002Fs13353-016-0341-x",{"doi":6777},"10.1007\u002Fs13353-016-0341-x",{"id":21,"text":6779,"url":21,"identifiers":6780},"Muranaka, 2009, Efficient design strategy for whole-cell and cell-free biosensors based on engineered riboswitches, Anal. Lett., 42, 108, 10.1080\u002F00032710802568556",{"doi":6781},"10.1080\u002F00032710802568556",{"id":21,"text":6783,"url":21,"identifiers":6784},"Paige, 2012, Fluorescence imaging of cellular metabolites with RNA, Science, 335, 1194, 10.1126\u002Fscience.1218298",{"doi":6785},"10.1126\u002Fscience.1218298",{"id":21,"text":6787,"url":21,"identifiers":6788},"Kundert, K., Lucas, J.E., Watters, K.E., Fellmann, C., Ng, A.H., Heineike, B.M., Fitzsimmons, C.M., Oakes, B.L., Savage, D.F., and El-Samad, H. (2018). Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs. bioRxiv.",{"doi":6789},"10.1101\u002F323105",{"id":21,"text":6791,"url":21,"identifiers":6792},"Gilbert, 2009, Adaptive ligand binding by the purine riboswitch in the recognition of guanine and adenine analogs, Structure, 17, 857, 10.1016\u002Fj.str.2009.04.009",{"doi":6793},"10.1016\u002Fj.str.2009.04.009",{"id":21,"text":6795,"url":21,"identifiers":6796},"Mironov, 2002, Sensing small molecules by nascent RNA: A mechanism to control transcription in bacteria, Cell, 111, 747, 10.1016\u002FS0092-8674(02)01134-0",{"doi":6797},"10.1016\u002FS0092-8674(02)01134-0",{"id":21,"text":6799,"url":21,"identifiers":6800},"Thore, 2006, Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand, Science, 312, 1208, 10.1126\u002Fscience.1128451",{"doi":6801},"10.1126\u002Fscience.1128451",{"id":21,"text":6803,"url":21,"identifiers":6804},"Hallberg, 2017, Engineering and in vivo applications of riboswitches, Annu. Rev. Biochem., 86, 515, 10.1146\u002Fannurev-biochem-060815-014628",{"doi":6805},"10.1146\u002Fannurev-biochem-060815-014628",{"id":21,"text":6807,"url":21,"identifiers":6808},"Palchetti, 2012, Electrochemical nanomaterial-based nucleic acid aptasensors, Anal. Bioanal. Chem., 402, 3103, 10.1007\u002Fs00216-012-5769-1",{"doi":6809},"10.1007\u002Fs00216-012-5769-1",{"id":21,"text":6811,"url":21,"identifiers":6812},"Crulhas, 2017, An electrochemical aptasensor for detection of bovine interferon gamma, Anal. Methods, 9, 4527, 10.1039\u002FC7AY01313B",{"doi":6813},"10.1039\u002FC7AY01313B",{"id":21,"text":6815,"url":21,"identifiers":6816},"Meirinho, 2014, Development of an electrochemical aptasensor for the detection of human osteopontin, Procedia Eng., 87, 316, 10.1016\u002Fj.proeng.2014.11.671",{"doi":6817},"10.1016\u002Fj.proeng.2014.11.671",{"id":21,"text":6819,"url":21,"identifiers":6820},"Song, 2013, Imaging bacterial protein expression using genetically encoded RNA sensors, Nat. Methods, 10, 873, 10.1038\u002Fnmeth.2568",{"doi":6821},"10.1038\u002Fnmeth.2568",{"id":21,"text":6823,"url":21,"identifiers":6824},"Stein, 2015, Synthetic protein switches: Design principles and applications, Trends Biotechnol., 33, 101, 10.1016\u002Fj.tibtech.2014.11.010",{"doi":6825},"10.1016\u002Fj.tibtech.2014.11.010",{"id":21,"text":6827,"url":21,"identifiers":6828},"Ostermeier, 2000, Evolution of protein function by domain swapping, Adv. Protein Chem., 55, 29, 10.1016\u002FS0065-3233(01)55002-0",{"doi":6829},"10.1016\u002FS0065-3233(01)55002-0",{"id":21,"text":6831,"url":21,"identifiers":6832},"Nagai, 2001, Circularly permuted green fluorescent proteins engineered to sense Ca2+, Proc. Natl. Acad. Sci. USA, 98, 3197, 10.1073\u002Fpnas.051636098",{"doi":6833},"10.1073\u002Fpnas.051636098",{"id":21,"text":6835,"url":21,"identifiers":6836},"Yu, 2011, Circular permutation: A different way to engineer enzyme structure and function, Trends Biotechnol., 29, 18, 10.1016\u002Fj.tibtech.2010.10.004",{"doi":6837},"10.1016\u002Fj.tibtech.2010.10.004",{"id":21,"text":6839,"url":21,"identifiers":6840},"Guntas, 2004, A molecular switch created by in vitro recombination of nonhomologous genes, Chem. Biol., 11, 1483, 10.1016\u002Fj.chembiol.2004.08.020",{"doi":6841},"10.1016\u002Fj.chembiol.2004.08.020",{"id":21,"text":6843,"url":21,"identifiers":6844},"Baird, 1999, Circular permutation and receptor insertion within green fluorescent proteins, Proc. Natl. Acad. Sci. USA, 96, 11241, 10.1073\u002Fpnas.96.20.11241",{"doi":6845},"10.1073\u002Fpnas.96.20.11241",{"id":21,"text":6847,"url":21,"identifiers":6848},"Ikura, 1992, Solution structure of a calmodulin-target peptide complex by multidimensional NMR, Science, 256, 632, 10.1126\u002Fscience.1585175",{"doi":6849},"10.1126\u002Fscience.1585175",{"id":21,"text":6851,"url":21,"identifiers":6852},"Guo, 2016, Engineered PQQ-glucose dehydrogenase as a universal biosensor platform, J. Am. Chem. Soc., 138, 10108, 10.1021\u002Fjacs.6b06342",{"doi":6853},"10.1021\u002Fjacs.6b06342",{"id":21,"text":6855,"url":21,"identifiers":6856},"Okuda, 2004, PQQ glucose dehydrogenase with novel electron transfer ability, Biochem. Biophys. Res. Commun., 314, 793, 10.1016\u002Fj.bbrc.2003.12.167",{"doi":6857},"10.1016\u002Fj.bbrc.2003.12.167",{"id":21,"text":6859,"url":21,"identifiers":6860},"Igarashi, 2004, Molecular engineering of PQQGDH and its applications, Arch. Biochem. Biophys., 428, 52, 10.1016\u002Fj.abb.2004.06.001",{"doi":6861},"10.1016\u002Fj.abb.2004.06.001",{"id":21,"text":6863,"url":21,"identifiers":6864},"Psoma, 2010, A novel enzyme entrapment in SU-8 microfabricated films for glucose micro-biosensors, Biosens. Bioelectron., 26, 1582, 10.1016\u002Fj.bios.2010.07.117",{"doi":6865},"10.1016\u002Fj.bios.2010.07.117",{"id":21,"text":6867,"url":21,"identifiers":6868},"Guo, 2016, Engineering PQQ-glucose dehydrogenase into an allosteric electrochemical Ca2+ sensor, Chem. Commun., 52, 485, 10.1039\u002FC5CC07824E",{"doi":6869},"10.1039\u002FC5CC07824E",{"id":21,"text":6871,"url":21,"identifiers":6872},"Huang, 2010, Rational conversion of affinity reagents into label-free sensors for peptide motifs by designed allostery, ACS Chem. Biol., 5, 273, 10.1021\u002Fcb900284c",{"doi":6873},"10.1021\u002Fcb900284c",{"id":21,"text":6875,"url":21,"identifiers":6876},"Huang, 2009, Structural basis for exquisite specificity of affinity clamps, synthetic binding proteins generated through directed domain-interface evolution, J. Mol. Biol., 392, 1221, 10.1016\u002Fj.jmb.2009.07.067",{"doi":6877},"10.1016\u002Fj.jmb.2009.07.067",{"id":21,"text":6879,"url":21,"identifiers":6880},"Stein, 2014, Protease-based synthetic sensing and signal amplification, Proc. Natl. Acad. Sci. USA, 111, 15934, 10.1073\u002Fpnas.1405220111",{"doi":6881},"10.1073\u002Fpnas.1405220111",{"id":21,"text":6883,"url":21,"identifiers":6884},"Sharma, 2016, Antibodies and antibody-derived analytical biosensors, Essays Biochem., 60, 9, 10.1042\u002FEBC20150002",{"doi":6885},"10.1042\u002FEBC20150002",{"id":6887,"createTime":6888,"updateTime":6888,"relativeEntities":6889,"slug":6890,"properties":6891,"entityType":964,"verifyStatus":121,"verifyTime":6888,"verifyNote":1071,"languages":6906,"translateLanguages":21,"viewCount":22,"primaryUrl":6907,"fullTextUrl":21,"authors":6908,"publicationType":991,"publisherRelationship":7041,"citationCount":663,"citationInfo":7094,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":7096,"openAccess":21,"references":7097,"isForceReanalyzing":1050},"1680a481-5166-4739-8769-75966a03707b","2024-11-27T23:21:37.626+00:00",[],"Air-Quality-Effects-on-Human-Health-and-Approaches-for-Its-Assessment-through-Microfluidic-Chips",{"mag":6892,"pmc":6894,"openalex":6896,"abstract":6898,"title":6900,"pm":6902,"doi":6904},{"VOID":6893},"2760339158",{"VOID":6895},"5664094",{"VOID":6897},"W2760339158",{"EN":6899},"\u003Cjats:p>Air quality depends on the various gases and particles present in it. Both natural phenomena and human activities affect the cleanliness of air. In the last decade, many countries experienced an unprecedented industrial growth, resulting in changing air quality values, and correspondingly, affecting our life quality. Air quality can be accessed by employing microchips that qualitatively and quantitatively determine the present gases and dust particles. The so-called particular matter 2.5 (PM2.5) values are of high importance, as such small particles can penetrate the human lung barrier and enter the blood system. There are cancer cases related to many air pollutants, and especially to PM2.5, contributing to exploding costs within the healthcare system. We focus on various current and potential future air pollutants, and propose solutions on how to protect our health against such dangerous substances. Recent developments in the Organ-on-Chip (OoC) technology can be used to study air pollution as well. 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2008, Nanotoxicology: The asbestos analogy revisited, Nat. Nanotechnol., 3, 378, 10.1038\u002Fnnano.2008.182",{"doi":7101},"10.1038\u002Fnnano.2008.182",{"id":21,"text":7103,"url":21,"identifiers":7104},"Qu, H. (2016). CMOS MEMS Fabrication Technologies and Devices. Micromachines, 7.",{"doi":7105},"10.3390\u002Fmi7010014",{"id":21,"text":7107,"url":21,"identifiers":7108},"Bhatia, 2014, Microfluidic organs-on-chips, Nat. Biotechnol., 32, 760, 10.1038\u002Fnbt.2989",{"doi":7109},"10.1038\u002Fnbt.2989",{"id":21,"text":7111,"url":21,"identifiers":7112},"Hajati, 2012, Three-dimensional micro electromechanical system piezoelectric ultrasound transducer, Appl. Phys. Lett., 101, 253101, 10.1063\u002F1.4772469",{"doi":7113},"10.1063\u002F1.4772469",{"id":21,"text":7115,"url":21,"identifiers":7116},"Hajati, 2013, Monolithic ultrasonic integrated circuits based on micromachined semi-ellipsoidal piezoelectric domes, Appl Phys. Lett, 103, 202906, 10.1063\u002F1.4831988",{"doi":7117},"10.1063\u002F1.4831988",{"id":21,"text":7119,"url":21,"identifiers":7120},"Louizos, 2012, Microelectromechanical systems and nanotechnology: A platform for the next stent technological era, Vasc. Endovascular. Surg., 46, 605, 10.1177\u002F1538574412462637",{"doi":7121},"10.1177\u002F1538574412462637",{"id":21,"text":7123,"url":21,"identifiers":7124},"Nalayanda, 2009, An open-access microfluidic model for lung-specific functional studies at an air-liquid interface, Biomed. Microdevices, 11, 1081, 10.1007\u002Fs10544-009-9325-5",{"doi":7125},"10.1007\u002Fs10544-009-9325-5",{"id":21,"text":7127,"url":21,"identifiers":7128},"Zhu, 2017, Formaldehyde (HCHO) As a Hazardous Air Pollutant: Mapping Surface Air Concentrations from Satellite and Inferring Cancer Risks in the United States, Environ. Sci. Technol., 51, 5650, 10.1021\u002Facs.est.7b01356",{"doi":7129},"10.1021\u002Facs.est.7b01356",{"id":21,"text":7131,"url":21,"identifiers":7132},"Fiedziuszko, S.J. (2000, January 22–24). Applications of MEMS in communication satellites. Proceedings of the 13th International Conference on Microwaves, Radar and Wireless Communications, MIKON-2000, Conference Proceedings (IEEE Cat. No.00EX428), Wrocław, Poland.",{},{"id":21,"text":7134,"url":21,"identifiers":7135},"Kong, 2016, The empirical correlations between PM2.5, PM10 and AOD in the Beijing metropolitan region and the PM2.5, PM10 distributions retrieved by MODIS, Environ. Pollut., 216, 350, 10.1016\u002Fj.envpol.2016.05.085",{"doi":7136},"10.1016\u002Fj.envpol.2016.05.085",{"id":21,"text":7138,"url":21,"identifiers":7139},"World Air Quality Index Team (2017, September 25). The World Air Quality Index Project. Available online: http:\u002F\u002Faqicn.org\u002Fcontact\u002F.",{},{"id":21,"text":7141,"url":21,"identifiers":7142},"Castell, 2017, Can commercial low-cost sensor platforms contribute to air quality monitoring and exposure estimates?, Environ. Int., 99, 293, 10.1016\u002Fj.envint.2016.12.007",{"doi":7143},"10.1016\u002Fj.envint.2016.12.007",{"id":21,"text":7145,"url":21,"identifiers":7146},"Knight, 2007, Systematic reviews of animal experiments demonstrate poor human clinical and toxicological utility, Altern. Lab. Anim., 35, 641, 10.1177\u002F026119290703500610",{"doi":7147},"10.1177\u002F026119290703500610",{"id":21,"text":7149,"url":21,"identifiers":7150},"Akhtar, 2015, The flaws and human harms of animal experimentation, Camb. Q. Healthc. Ethics, 24, 407, 10.1017\u002FS0963180115000079",{"doi":7151},"10.1017\u002FS0963180115000079",{"id":21,"text":7153,"url":21,"identifiers":7154},"Zheng, 2016, Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems, Small, 12, 2253, 10.1002\u002Fsmll.201503208",{"doi":7155},"10.1002\u002Fsmll.201503208",{"id":21,"text":7157,"url":21,"identifiers":7158},"Capulli, 2014, Approaching the in vitro clinical trial: Engineering organs on chips, Lab Chip, 14, 3181, 10.1039\u002FC4LC00276H",{"doi":7159},"10.1039\u002FC4LC00276H",{"id":21,"text":7161,"url":21,"identifiers":7162},"Konar, 2016, Lung-On-A-Chip Technologies for Disease Modeling and Drug Development, Biomed. Eng. Comput. Biol., 7, 17",{},{"id":21,"text":7164,"url":21,"identifiers":7165},"Benam, 2016, Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip, Cell Syst., 3, 456, 10.1016\u002Fj.cels.2016.10.003",{"doi":7166},"10.1016\u002Fj.cels.2016.10.003",{"id":21,"text":7168,"url":21,"identifiers":7169},"Holland, 2006, The oxygenation of the atmosphere and oceans, Philos. Trans. R. Soc. Lond. B Biol. Sci., 361, 903, 10.1098\u002Frstb.2006.1838",{"doi":7170},"10.1098\u002Frstb.2006.1838",{"id":21,"text":7172,"url":21,"identifiers":7173},"Berner, 1999, Atmospheric oxygen over Phanerozoic time, Proc. Natl. Acad. Sci. USA, 96, 10955, 10.1073\u002Fpnas.96.20.10955",{"doi":7174},"10.1073\u002Fpnas.96.20.10955",{"id":21,"text":7176,"url":21,"identifiers":7177},"Ward, P.D. (2006). Out of Thin Air: Dinosaurs, Birds, and Earth’s Ancient Atmosphere, The National Academies Press.",{},{"id":21,"text":7179,"url":21,"identifiers":7180},"Crowe, 2013, Atmospheric oxygenation three billion years ago, Nature, 501, 535, 10.1038\u002Fnature12426",{"doi":7181},"10.1038\u002Fnature12426",{"id":21,"text":7183,"url":21,"identifiers":7184},"Fischer, 2014, Breathing Life into Oxygen, Science, 343, 840, 10.1126\u002Fscience.1248669",{"doi":7185},"10.1126\u002Fscience.1248669",{"id":21,"text":7187,"url":21,"identifiers":7188},"Chen, 2007, Estimates of atmospheric dry deposition and associated input of nutrients to Gulf of Aqaba seawater, J. Geophys. Res., 112, D04309",{},{"id":21,"text":7190,"url":21,"identifiers":7191},"Walsh, 2001, Saharan dust and Florida red tides: The cyanophyte connection, J. Geophys. Res. Oceans, 106, 11597, 10.1029\u002F1999JC000123",{"doi":7192},"10.1029\u002F1999JC000123",{"id":21,"text":7194,"url":21,"identifiers":7195},"Stenchikov, 2015, The impact of dust storms on the Arabian Peninsula and the Red Sea, Atmos. Chem. Phys., 15, 199, 10.5194\u002Facp-15-199-2015",{"doi":7196},"10.5194\u002Facp-15-199-2015",{"id":21,"text":7198,"url":21,"identifiers":7199},"Klepeis, 2001, The National Human Activity Pattern Survey (NHAPS): A resource for assessing exposure to environmental pollutants, J. Expo. Anal. Environ. Epidemiol., 11, 231, 10.1038\u002Fsj.jea.7500165",{"doi":7200},"10.1038\u002Fsj.jea.7500165",{"id":21,"text":7202,"url":21,"identifiers":7203},"Ezzati, 2005, Indoor air pollution and health in developing countries, Lancet, 366, 104, 10.1016\u002FS0140-6736(05)66845-6",{"doi":7204},"10.1016\u002FS0140-6736(05)66845-6",{"id":21,"text":7206,"url":21,"identifiers":7207},"Guan, 2016, Impact of air pollution on the burden of chronic respiratory diseases in China: Time for urgent action, Lancet, 388, 1939, 10.1016\u002FS0140-6736(16)31597-5",{"doi":7208},"10.1016\u002FS0140-6736(16)31597-5",{"id":21,"text":7210,"url":21,"identifiers":7211},"The, 2014, Improving air quality starts at home, Lancet, 384, 1821, 10.1016\u002FS0140-6736(14)62227-3",{"doi":7212},"10.1016\u002FS0140-6736(14)62227-3",{"id":21,"text":7214,"url":21,"identifiers":7215},"Duflo, E., Greenstone, M., and Hanna, R. (2008). Indoor air pollution, health and economic well-being. SAPIENS [Online], 1.",{"doi":7216},"10.5194\u002Fsapiens-1-1-2008",{"id":21,"text":7218,"url":21,"identifiers":7219},"Bruce, 2000, Indoor air pollution in developing countries: A major environmental and public health challenge, Bull. World Health Organ., 78, 1078",{},{"id":21,"text":7221,"url":21,"identifiers":7222},"Kilpatrick, K. (2017, September 25). Sick Classrooms Caused by Rising CO2 Levels. Available online: http:\u002F\u002Fenergyalliancegroup.org\u002Fsick-classrooms-require-energy-efficient-solutions-2\u002F.",{},{"id":21,"text":7224,"url":21,"identifiers":7225},"The National Institute for Occupational Safety and Health (NIOSH) (2017, September 25). Indoor Environmental Quality, Available online: https:\u002F\u002Fwww.cdc.gov\u002Fniosh\u002Ftopics\u002Findoorenv\u002FBuildingVentilation.html.",{},{"id":21,"text":7227,"url":21,"identifiers":7228},"(EPD), T.E.B.a.t.E.P.D (2017, September 25). Hong Kong Government Initiatives to Improve Indoor Air Quality. Available online: https:\u002F\u002Fweb.archive.org\u002Fweb\u002F20160108175015\u002Fhttp:\u002Fzcada.net\u002Fhk-government-initiatives-improve-iaq\u002F.",{},{"id":21,"text":7230,"url":21,"identifiers":7231},"Arc Suppression Technologies (Environmental Impact—Of Arc Suppression, 2013). Environmental Impact—Of Arc Suppression, Lab. Note #106.",{},{"id":21,"text":7233,"url":21,"identifiers":7234},"United States Environmental Protection Agency (EPA) (2017, September 25). Ozone Generators that Are Sold as Air Cleaners, Available online: https:\u002F\u002Fwww.epa.gov\u002Findoor-air-quality-iaq\u002Fozone-generators-are-sold-air-cleaners.",{},{"id":21,"text":7236,"url":21,"identifiers":7237},"Apte, 2008, Outdoor ozone and building-related symptoms in the BASE study, Indoor Air, 18, 156, 10.1111\u002Fj.1600-0668.2008.00521.x",{"doi":7238},"10.1111\u002Fj.1600-0668.2008.00521.x",{"id":21,"text":7240,"url":21,"identifiers":7241},"Talk of the Nation (2007). Study: Bad In-Flight Air Exacerbated by Passengers, Research News.",{},{"id":21,"text":7243,"url":21,"identifiers":7244},"Kusky, T.M. (2003). Geological Hazards: A Sourcebook, Greenwood Publishing Group.",{},{"id":21,"text":7246,"url":21,"identifiers":7247},"Godish, T. (2000). Indoor Environment Quality, CRC Press.",{},{"id":21,"text":7249,"url":21,"identifiers":7250},"Ubysz, 2017, Radon—Occurrence and Health Risks in Civil Engineering, Proc. Eng., 172, 1184, 10.1016\u002Fj.proeng.2017.02.138",{"doi":7251},"10.1016\u002Fj.proeng.2017.02.138",{"id":21,"text":7253,"url":21,"identifiers":7254},"United States Environmental Protection Agency (2017, September 25). A Citizen’s Guide to Radon: The Guide to Protecting Yourself and Your Family from Radon, Available online: https:\u002F\u002Fwww.epa.gov\u002Fradon\u002Fcitizens-guide-radon-guide-protecting-yourself-and-your-family-radon.",{},{"id":21,"text":7256,"url":21,"identifiers":7257},"WHO (2017, September 25). Radon and Health, Fact Sheet. Available online: http:\u002F\u002Fwww.who.int\u002Fmediacentre\u002Ffactsheets\u002Ffs291\u002Fen\u002F.",{},{"id":21,"text":7259,"url":21,"identifiers":7260},"American Cancer Society (ACS) (2017, September 25). Known and Probable Human Carcinogens. Available online: https:\u002F\u002Fwww.cancer.org\u002Fcancer\u002Fcancer-causes\u002Fgeneral-info\u002Fknown-and-probable-human-carcinogens.html#additional_resources.",{},{"id":21,"text":7262,"url":21,"identifiers":7263},"Roscoe, 1989, Lung Cancer Mortality Among Nonsmoking Uranium Miners Exposed to Radon Daughters, JAMA J. Am. Med. Assoc., 262, 629, 10.1001\u002Fjama.1989.03430050045024",{"doi":7264},"10.1001\u002Fjama.1989.03430050045024",{"id":21,"text":7266,"url":21,"identifiers":7267},"Tirmarche, M., Laurier, D., Mitton, N., and Gelas, J. (2000, January 14–19). Lung cancer risk associated with low chronic radon exposure. Results from the French uranium miners cohort and the European project. Proceedings of the 10th International Congress of the International Radiation Protection\u002FAssociation on Harmonization of Radiation, Human Life and the Ecosystem, Tokyo, Japan.",{},{"id":21,"text":7269,"url":21,"identifiers":7270},"Darby, 2001, Radon: A likely carcinogen at all exposures, Ann. Oncol., 12, 1341, 10.1023\u002FA:1012518223463",{"doi":7271},"10.1023\u002FA:1012518223463",{"id":21,"text":7273,"url":21,"identifiers":7274},"Catelinois, 2006, Lung cancer attributable to indoor radon exposure in france: Impact of the risk models and uncertainty analysis, Environ. Health Perspect., 114, 1361, 10.1289\u002Fehp.9070",{"doi":7275},"10.1289\u002Fehp.9070",{"id":21,"text":7277,"url":21,"identifiers":7278},"Darby, 2005, Radon in homes and risk of lung cancer: Collaborative analysis of individual data from 13 European case-control studies, BMJ, 330, 223, 10.1136\u002Fbmj.38308.477650.63",{"doi":7279},"10.1136\u002Fbmj.38308.477650.63",{"id":21,"text":7281,"url":21,"identifiers":7282},"Rericha, 2006, Incidence of leukemia, lymphoma, and multiple myeloma in Czech uranium miners: A case-cohort study, Environ. Health Perspect., 114, 818, 10.1289\u002Fehp.8476",{"doi":7283},"10.1289\u002Fehp.8476",{"id":21,"text":7285,"url":21,"identifiers":7286},"Wolkoff, 2007, The dichotomy of relative humidity on indoor air quality, Environ. Int., 33, 850, 10.1016\u002Fj.envint.2007.04.004",{"doi":7287},"10.1016\u002Fj.envint.2007.04.004",{"id":21,"text":7289,"url":21,"identifiers":7290},"Cosgrove-Mather, B. (2017, September 25). FDA: Too Much Benzene in Some Drinks. Available online: http:\u002F\u002Fwww.cbsnews.com\u002Fnews\u002Ffda-too-much-benzene-in-some-drinks\u002F.",{},{"id":21,"text":7292,"url":21,"identifiers":7293},"Wexler, P. (2005). Encyclopedia of Toxicology, “Chloroform”, Elsevier. [2nd ed.].",{},{"id":21,"text":7295,"url":21,"identifiers":7296},"United States Environmental Protection Agency (2017, September 25). Organic Chemicals, Plastics and Synthetic Fibers Effluent Guidelines, Available online: https:\u002F\u002Fwww.epa.gov\u002Feg\u002Forganic-chemicals-plastics-and-synthetic-fibers-effluent-guidelines.",{},{"id":21,"text":7298,"url":21,"identifiers":7299},"Meruva, 2004, Rapid identification of microbial VOCs from tobacco molds using closed-loop stripping and gas chromatography\u002Ftime-of-flight mass spectrometry, J. Ind. Microbiol. Biotechnol., 31, 482, 10.1007\u002Fs10295-004-0175-0",{"doi":7300},"10.1007\u002Fs10295-004-0175-0",{"id":21,"text":7302,"url":21,"identifiers":7303},"Bioidea.net, a.B.C. (2017, September 25). Smelly, Musty, Moldy Houses. Available online: https:\u002F\u002Fwww.bioidea.net\u002Fresources\u002Fsmelly-musty-moldy-houses\u002F.",{},{"id":21,"text":7305,"url":21,"identifiers":7306},"Buszewski, 2007, Human exhaled air analytics: Biomarkers of diseases, Biomed. Chromatogr. BMC, 21, 553, 10.1002\u002Fbmc.835",{"doi":7307},"10.1002\u002Fbmc.835",{"id":21,"text":7309,"url":21,"identifiers":7310},"Renner, 2007, US EPA to revisit asbestos toxicity, Environ. Sci. Technol., 41, 1808",{},{"id":21,"text":7312,"url":21,"identifiers":7313},"Alleman, 1997, Asbestos revisited, Sci. Am., 277, 70, 10.1038\u002Fscientificamerican0797-70",{"doi":7314},"10.1038\u002Fscientificamerican0797-70",{"id":21,"text":7316,"url":21,"identifiers":7317},"Cooke, 1924, Fibrosis of the Lungs Due to the Inhalation of Asbestos Dust, BMJ, 2, 147, 10.1136\u002Fbmj.2.3317.147",{"doi":7318},"10.1136\u002Fbmj.2.3317.147",{"id":21,"text":7320,"url":21,"identifiers":7321},"Selikoff, 1991, A landmark case in asbestosis, JAMA, 265, 898, 10.1001\u002Fjama.1991.03460070080047",{"doi":7322},"10.1001\u002Fjama.1991.03460070080047",{"id":21,"text":7324,"url":21,"identifiers":7325},"Burke, B. (2001). Shipbuilding’s Deadly Legacy: Introduction: Horrible Toll Could Have Been Avoided, Virginian-Pilot Norfolk.",{},{"id":21,"text":7327,"url":21,"identifiers":7328},"Gualtieri, 2000, Thermal decomposition of asbestos and recycling in traditional ceramics, J. Eur. Ceram. Soc., 20, 1409, 10.1016\u002FS0955-2219(99)00290-3",{"doi":7329},"10.1016\u002FS0955-2219(99)00290-3",{"id":21,"text":7331,"url":21,"identifiers":7332},"2007, Adaptive immunity: Care for the community, Nature, 445, 153, 10.1038\u002F445153a",{"doi":7333},"10.1038\u002F445153a",{"id":21,"text":7335,"url":21,"identifiers":7336},"Pluschke, P. (2004). Indoor Air Pollution by Microorganisms and Their Metabolites. Air Pollution: Indoor Air Pollution, Springer.",{},{"id":21,"text":7338,"url":21,"identifiers":7339},"Levin, H. (1992). Can House Plants Solve IAQ Problems, Building Ecology Research Group.",{},{"id":21,"text":7341,"url":21,"identifiers":7342},"Wolverton, B.C., Johnson, A., and Bounds, K. (1989). Interior Landscape Plants for Indoor Air Pollution Abatement, NASA Stennis Space Center.",{},{"id":21,"text":7344,"url":21,"identifiers":7345},"Down, S. (2017, September 25). Houseplants as Air Fresheners. Available online: http:\u002F\u002Fwww.spectroscopynow.com\u002Fdetails\u002Fezine\u002Fsepspec22493ezine\u002FHouseplants-as-air-fresheners.html.",{},{"id":21,"text":7347,"url":21,"identifiers":7348},"Girman, J., Phillips, T., and Levin, H. (2017, September 25). Critical Review: How Well Do House Plants Perform as Indoor Air Cleaners?. Available online: http:\u002F\u002Fwww.buildingecology.com\u002Farticles\u002Fcritical-review-how-well-do-house-plants-perform-as-indoor-air-cleaners\u002F.",{},{"id":21,"text":7350,"url":21,"identifiers":7351},"Institute of Medicine (US) Committee on Damp Indoor Spaces and Health (2004). Damp Indoor Spaces and Health, The National Academies Press.",{},{"id":21,"text":7353,"url":21,"identifiers":7354},"Johnson, K. (2017, September 25). How Carbon Dioxide Became a ‘Pollutant’. Available online: https:\u002F\u002Fwww.wsj.com\u002Farticles\u002FSB124001537515830975.",{},{"id":21,"text":7356,"url":21,"identifiers":7357},"Goldstein, 2009, Biogenic carbon and anthropogenic pollutants combine to form a cooling haze over the southeastern United States, Proc. Natl. Acad. Sci. USA, 106, 8835, 10.1073\u002Fpnas.0904128106",{"doi":7358},"10.1073\u002Fpnas.0904128106",{"id":21,"text":7360,"url":21,"identifiers":7361},"Fischetti, M. (2014). The Paradox of Pollution-Producing Trees—Why some greenery can make smog worse. Sci. Am., 310.",{"doi":7362},"10.1038\u002Fscientificamerican0614-14",{"id":21,"text":7364,"url":21,"identifiers":7365},"Tomasi, C., and Lupi, A. (2017). Primary and Secondary Sources of Atmospheric Aerosol. Atmospheric Aerosols, Wiley-VCH Verlag GmbH & Co. KGaA.",{"doi":7366},"10.1002\u002F9783527336449.ch1",{"id":21,"text":7368,"url":21,"identifiers":7369},"Penner, J.E. (2001). Primary and Secondary Sources of Aerosols, The Intergovernmental Panel on Climate Change (IPCC).",{},{"id":21,"text":7371,"url":21,"identifiers":7372},"Rosenfeld, 2002, The role of sea spray in cleansing air pollution over ocean via cloud processes, Science, 297, 1667, 10.1126\u002Fscience.1073869",{"doi":7373},"10.1126\u002Fscience.1073869",{"id":21,"text":7375,"url":21,"identifiers":7376},"2008, Atmospheric chemistry: Pollution meets sea salt, Nat. Geosci., 1, 292, 10.1038\u002Fngeo192",{"doi":7377},"10.1038\u002Fngeo192",{"id":21,"text":7379,"url":21,"identifiers":7380},"Perraud, 2012, Nonequilibrium atmospheric secondary organic aerosol formation and growth, Proc. Natl. Acad. Sci. USA, 109, 2836, 10.1073\u002Fpnas.1119909109",{"doi":7381},"10.1073\u002Fpnas.1119909109",{"id":21,"text":7383,"url":21,"identifiers":7384},"Ilan, 2006, The Bodélé depression: A single spot in the Sahara that provides most of the mineral dust to the Amazon forest, Environ. Res. Lett., 1, 014005, 10.1088\u002F1748-9326\u002F1\u002F1\u002F014005",{"doi":7385},"10.1088\u002F1748-9326\u002F1\u002F1\u002F014005",{"id":21,"text":7387,"url":21,"identifiers":7388},"Sissakian, 2013, Sand and dust storm events in Iraq, Nat. Sci., 5, 1084",{},{"id":21,"text":7390,"url":21,"identifiers":7391},"Lee, 2013, Effect of Asian dust storms on daily mortality in seven metropolitan cities of Korea, Atmos. Environ., 79, 510, 10.1016\u002Fj.atmosenv.2013.06.046",{"doi":7392},"10.1016\u002Fj.atmosenv.2013.06.046",{"id":21,"text":7394,"url":21,"identifiers":7395},"Park, 2005, Effects of ambient particulate matter on peak expiratory flow rates and respiratory symptoms of asthmatics during Asian dust periods in Korea, Respirology, 10, 470, 10.1111\u002Fj.1440-1843.2005.00728.x",{"doi":7396},"10.1111\u002Fj.1440-1843.2005.00728.x",{"id":21,"text":7398,"url":21,"identifiers":7399},"Sandstrom, 2008, Desert dust: An unrecognized source of dangerous air pollution?, Epidemiology, 19, 808, 10.1097\u002FEDE.0b013e31818809e0",{"doi":7400},"10.1097\u002FEDE.0b013e31818809e0",{"id":21,"text":7402,"url":21,"identifiers":7403},"Raloff, 2001, Ill Winds, Sci. News, 160, 218, 10.2307\u002F4012814",{"doi":7404},"10.2307\u002F4012814",{"id":21,"text":7406,"url":21,"identifiers":7407},"Buzea, 2007, Nanomaterials and nanoparticles: Sources and toxicity, Biointerphases, 2, MR17-71, 10.1116\u002F1.2815690",{"doi":7408},"10.1116\u002F1.2815690",{"id":21,"text":7410,"url":21,"identifiers":7411},"Marques, 2007, A call to arms: Coevolution of animal viruses and host innate immune responses, Trends Genet., 23, 359, 10.1016\u002Fj.tig.2007.04.004",{"doi":7412},"10.1016\u002Fj.tig.2007.04.004",{"id":21,"text":7414,"url":21,"identifiers":7415},"Kampa, 2008, Human health effects of air pollution, Environ. Pollut., 151, 362, 10.1016\u002Fj.envpol.2007.06.012",{"doi":7416},"10.1016\u002Fj.envpol.2007.06.012",{"id":21,"text":7418,"url":21,"identifiers":7419},"Omidvarborna, 2015, Recent studies on soot modeling for diesel combustion, Renew. Sustain. Energy Rev., 48, 635, 10.1016\u002Fj.rser.2015.04.019",{"doi":7420},"10.1016\u002Fj.rser.2015.04.019",{"id":21,"text":7422,"url":21,"identifiers":7423},"Horwitz, C., and Buchanan, M. (2017, September 25). Pollution and Society. Available online: http:\u002F\u002Fwww.umich.edu\u002F~gs265\u002Findex.html.",{},{"id":21,"text":7425,"url":21,"identifiers":7426},"Ritter, L., International Program on Chemical Safety, and Inter-Organization Programme for the Sound Management of Chemicals (1995). A Review of Selected Persistent Organic Pollutants: DDT, Aldrin, Dieldrin, Endrin, Chlordane, Heptachlor, Hexachlorobenzene, Mirex, Toxaphene, Polycholorinated Biphenyls, Dioxins and Furans, publisher not identified.",{},{"id":21,"text":7428,"url":21,"identifiers":7429},"Ritter, L., Solomon, K., Forget, J., Stemeroff, M., and O’Leary, C. (1995). Persistent Organic Pollutants, United Nations Environment Programme.",{},{"id":21,"text":7431,"url":21,"identifiers":7432},"Kelly, 2007, Food web-specific biomagnification of persistent organic pollutants, Science, 317, 236, 10.1126\u002Fscience.1138275",{"doi":7433},"10.1126\u002Fscience.1138275",{"id":21,"text":7435,"url":21,"identifiers":7436},"Beyer, 2000, Assessing Long-Range Transport Potential of Persistent Organic Pollutants, Environ. Sci. Technol., 34, 699, 10.1021\u002Fes990207w",{"doi":7437},"10.1021\u002Fes990207w",{"id":21,"text":7439,"url":21,"identifiers":7440},"Vallack, 1998, Controlling persistent organic pollutants-what next?, Environ. Toxicol. Pharmacol., 6, 143, 10.1016\u002FS1382-6689(98)00036-2",{"doi":7441},"10.1016\u002FS1382-6689(98)00036-2",{"id":21,"text":7443,"url":21,"identifiers":7444},"Breivik, 2016, Tracking the Global Distribution of Persistent Organic Pollutants Accounting for E-Waste Exports to Developing Regions, Environ. Sci. Technol., 50, 798, 10.1021\u002Facs.est.5b04226",{"doi":7445},"10.1021\u002Facs.est.5b04226",{"id":21,"text":7447,"url":21,"identifiers":7448},"Walker, C.H. (2008). Organic Pollutants: An Ecotoxicological Perspective, CRC Press. [2nd ed.].",{"doi":7449},"10.1201\u002F9781420062595",{"id":21,"text":7451,"url":21,"identifiers":7452},"Szabo, D.T., and Loccisano, A.E. (4141). POPs and Human Health Risk Assessment. Dioxins and Health, John Wiley & Sons, Inc.",{},{"id":21,"text":7454,"url":21,"identifiers":7455},"Barringer, F. (2012). Scientists Find New Dangers in Tiny but Pervasive Particles in Air Pollution, New York Times.",{},{"id":21,"text":7457,"url":21,"identifiers":7458},"Brown, 2013, Thoracic and respirable particle definitions for human health risk assessment, Part. Fibre Toxicol., 10, 12, 10.1186\u002F1743-8977-10-12",{"doi":7459},"10.1186\u002F1743-8977-10-12",{"id":21,"text":7461,"url":21,"identifiers":7462},"Yamago, 1995, In vivo biological behavior of a water-miscible fullerene: 14C labeling, absorption, distribution, excretion and acute toxicity, Chem. Biol., 2, 385, 10.1016\u002F1074-5521(95)90219-8",{"doi":7463},"10.1016\u002F1074-5521(95)90219-8",{"id":21,"text":7465,"url":21,"identifiers":7466},"National PEP Weighing Laboratory, US-EPA, Region 4 (2017, September 25). PM2.5 Objectives and History, Available online: https:\u002F\u002Farchive.epa.gov\u002Fpesticides\u002Fregion4\u002Fsesd\u002Fpm25\u002Fweb\u002Fhtml\u002Fp2.html.",{},{"id":21,"text":7468,"url":21,"identifiers":7469},"Olsson, 1999, Atmospheric Chemistry and Physics: From Air Pollution to Climate Change, J. Am. Chem. Soc., 121, 1423, 10.1021\u002Fja985605y",{"doi":7470},"10.1021\u002Fja985605y",{"id":21,"text":7472,"url":21,"identifiers":7473},"Seinfeld, J.H., and Pandis, S.N. (1998). Atmospheric Chemistry and Physics: From Air Pollution to Climate Change, Wiley.",{"doi":7474},"10.1063\u002F1.882420",{"id":21,"text":7476,"url":21,"identifiers":7477},"Hamra, 2014, Outdoor particulate matter exposure and lung cancer: A systematic review and meta-analysis, Environ. Health Perspect., 122, 906, 10.1289\u002Fehp\u002F1408092",{"doi":7478},"10.1289\u002Fehp\u002F1408092",{"id":21,"text":7480,"url":21,"identifiers":7481},"Andersen, 2013, Air pollution and lung cancer incidence in 17 European cohorts: Prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE), Lancet Oncol., 14, 813, 10.1016\u002FS1470-2045(13)70279-1",{"doi":7482},"10.1016\u002FS1470-2045(13)70279-1",{"id":21,"text":7484,"url":21,"identifiers":7485},"Beelen, 2016, Particulate matter air pollution components and risk for lung cancer, Environ. Int., 87, 66, 10.1016\u002Fj.envint.2015.11.007",{"doi":7486},"10.1016\u002Fj.envint.2015.11.007",{"id":21,"text":7488,"url":21,"identifiers":7489},"Cesaroni, 2014, Long term exposure to ambient air pollution and incidence of acute coronary events: Prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE Project, BMJ, 348, f7412, 10.1136\u002Fbmj.f7412",{"doi":7490},"10.1136\u002Fbmj.f7412",{"id":21,"text":7492,"url":21,"identifiers":7493},"Helmholtz Zentrum München-German Research Center for Environmental Health (2014). Particulate Air Pollution Leads to Increased Heart Attack Risk, Science Daily.",{},{"id":21,"text":7495,"url":21,"identifiers":7496},"Doyle, K. (2016). Pollution Particles Damage Blood Vessels, May Lead to Heart Disease, Reuters.",{},{"id":21,"text":7498,"url":21,"identifiers":7499},"Du, 2015, Air particulate matter and cardiovascular disease: The epidemiological, biomedical and clinical evidence, J. Thorac. Dis., 8, E8",{},{"id":21,"text":7501,"url":21,"identifiers":7502},"Silverman, 2012, The Diesel Exhaust in Miners study: A nested case-control study of lung cancer and diesel exhaust, J. Natl. Cancer Inst., 104, 855, 10.1093\u002Fjnci\u002Fdjs034",{"doi":7503},"10.1093\u002Fjnci\u002Fdjs034",{"id":21,"text":7505,"url":21,"identifiers":7506},"Attfield, 2012, The Diesel Exhaust in Miners study: A cohort mortality study with emphasis on lung cancer, J. Natl. Cancer Inst., 104, 869, 10.1093\u002Fjnci\u002Fdjs035",{"doi":7507},"10.1093\u002Fjnci\u002Fdjs035",{"id":21,"text":7509,"url":21,"identifiers":7510},"Neslen, A. (2016). Diesel Cars May Be Worse Than Petrol for Carbon Emissions, Report Claims, Guardian.",{},{"id":21,"text":7512,"url":21,"identifiers":7513},"Brugge, 2007, Near-highway pollutants in motor vehicle exhaust: A review of epidemiologic evidence of cardiac and pulmonary health risks, Environ. Health, 6, 23, 10.1186\u002F1476-069X-6-23",{"doi":7514},"10.1186\u002F1476-069X-6-23",{"id":21,"text":7516,"url":21,"identifiers":7517},"Garshick, 2008, Lung cancer and vehicle exhaust in trucking industry workers, Environ. Health Perspect., 116, 1327, 10.1289\u002Fehp.11293",{"doi":7518},"10.1289\u002Fehp.11293",{"id":21,"text":7520,"url":21,"identifiers":7521},"Garshick, 2012, Lung cancer and elemental carbon exposure in trucking industry workers, Environ. Health Perspect., 120, 1301, 10.1289\u002Fehp.1204989",{"doi":7522},"10.1289\u002Fehp.1204989",{"id":21,"text":7524,"url":21,"identifiers":7525},"Lee, 2012, Ambient air pollution exposure and blood pressure changes during pregnancy, Environ. Res., 117, 46, 10.1016\u002Fj.envres.2012.05.011",{"doi":7526},"10.1016\u002Fj.envres.2012.05.011",{"id":21,"text":7528,"url":21,"identifiers":7529},"Fleischer, 2014, Outdoor air pollution, preterm birth, and low birth weight: Analysis of the world health organization global survey on maternal and perinatal health, Environ. Health Perspect., 122, 425, 10.1289\u002Fehp.1306837",{"doi":7530},"10.1289\u002Fehp.1306837",{"id":21,"text":7532,"url":21,"identifiers":7533},"Erickson, 2014, The shared pathoetiological effects of particulate air pollution and the social environment on fetal-placental development, J. Environ. Public Health, 2014, 901017, 10.1155\u002F2014\u002F901017",{"doi":7534},"10.1155\u002F2014\u002F901017",{"id":21,"text":7536,"url":21,"identifiers":7537},"Byrne, 2000, Fetal origins of adult disease: Epidemiology and mechanisms, J. Clin. Pathol., 53, 822, 10.1136\u002Fjcp.53.11.822",{"doi":7538},"10.1136\u002Fjcp.53.11.822",{"id":21,"text":7540,"url":21,"identifiers":7541},"Woodruff, 2009, Methodological issues in studies of air pollution and reproductive health, Environ. Res., 109, 311, 10.1016\u002Fj.envres.2008.12.012",{"doi":7542},"10.1016\u002Fj.envres.2008.12.012",{"id":21,"text":7544,"url":21,"identifiers":7545},"Cohen, 2005, The global burden of disease due to outdoor air pollution, J. Toxicol. Environ. Health A, 68, 1301, 10.1080\u002F15287390590936166",{"doi":7546},"10.1080\u002F15287390590936166",{"id":21,"text":7548,"url":21,"identifiers":7549},"McGrath, M. (2016). Four Major Cities Move to Ban Diesel Vehicles by 2025, BBC News.",{},{"id":21,"text":7551,"url":21,"identifiers":7552},"Harte, J., Holdren, C., Schneider, R., and Shirley, C. (1991). Toxics A to Z: A Guide to Everyday Pollution Hazards, University of California Press.",{},{"id":21,"text":7554,"url":21,"identifiers":7555},"Gordon, B., Mackay, R., and Rehfuess, E. (2004). Polluted Cities: The Air Children Breathe. Inheriting the World: The Atlas of Children’s Health & the Environment, WHO.",{},{"id":21,"text":7557,"url":21,"identifiers":7558},"Delorme, 2016, A NEMS-Array Control IC for Subattogram Mass Sensing Applications in 28 nm CMOS Technology, IEEE J. Solid-State Circuits, 51, 249, 10.1109\u002FJSSC.2015.2492782",{"doi":7559},"10.1109\u002FJSSC.2015.2492782",{"id":21,"text":7561,"url":21,"identifiers":7562},"Lussac, 2016, Review on Micro-Gas Analyzer Systems: Feasibility, Separations and Applications, Crit. Rev. Anal. Chem., 46, 455, 10.1080\u002F10408347.2016.1150153",{"doi":7563},"10.1080\u002F10408347.2016.1150153",{"id":21,"text":7565,"url":21,"identifiers":7566},"Wetchakun, 2011, Semiconducting metal oxides as sensors for environmentally hazardous gases, Sens. Actuators B Chem., 160, 580, 10.1016\u002Fj.snb.2011.08.032",{"doi":7567},"10.1016\u002Fj.snb.2011.08.032",{"id":21,"text":7569,"url":21,"identifiers":7570},"Fanget, 2011, Gas sensors based on gravimetric detection—A review, Sens. Actuators B Chem., 160, 804, 10.1016\u002Fj.snb.2011.08.066",{"doi":7571},"10.1016\u002Fj.snb.2011.08.066",{"id":21,"text":7573,"url":21,"identifiers":7574},"Lee, 2012, Functionalization layers for CO2 sensing using capacitive micromachined ultrasonic transducers, Sens. Actuators B Chem., 174, 87, 10.1016\u002Fj.snb.2012.08.025",{"doi":7575},"10.1016\u002Fj.snb.2012.08.025",{"id":21,"text":7577,"url":21,"identifiers":7578},"Barauskas, 2016, Greenhouse Gas Molecule CO2 Detection Using a Capacitive Micromachined Ultrasound Transducer, Anal. Chem., 88, 6662, 10.1021\u002Facs.analchem.6b02085",{"doi":7579},"10.1021\u002Facs.analchem.6b02085",{"id":21,"text":7581,"url":21,"identifiers":7582},"Kanan, 2009, Semiconducting metal oxide based sensors for selective gas pollutant detection, Sensors, 9, 8158, 10.3390\u002Fs91008158",{"doi":7583},"10.3390\u002Fs91008158",{"id":21,"text":7585,"url":21,"identifiers":7586},"Mirzaei, A., Janghorban, K., Hashemi, B., and Neri, G. (2015). Metal-core@metal oxide-shell nanomaterials for gas-sensing applications: A review. J. Nanopart. Res., 17.",{"doi":7587},"10.1007\u002Fs11051-015-3164-5",{"id":21,"text":7589,"url":21,"identifiers":7590},"Ding, 2004, Electrospun nanofibrous membranes coated quartz crystal microbalance as gas sensor for NH3 detection, Sens. Actuators B Chem., 101, 373, 10.1016\u002Fj.snb.2004.04.008",{"doi":7591},"10.1016\u002Fj.snb.2004.04.008",{"id":21,"text":7593,"url":21,"identifiers":7594},"Xianfeng, 2010, A highly sensitive humidity sensor based on a nanofibrous membrane coated quartz crystal microbalance, Nanotechnology, 21, 055502, 10.1088\u002F0957-4484\u002F21\u002F5\u002F055502",{"doi":7595},"10.1088\u002F0957-4484\u002F21\u002F5\u002F055502",{"id":21,"text":7597,"url":21,"identifiers":7598},"Venstra, 2014, Nanomechanical gas sensing with nonlinear resonant cantilevers, Nanotechnology, 25, 425501, 10.1088\u002F0957-4484\u002F25\u002F42\u002F425501",{"doi":7599},"10.1088\u002F0957-4484\u002F25\u002F42\u002F425501",{"id":21,"text":7601,"url":21,"identifiers":7602},"Fraiwan, 2016, A paper-based cantilever array sensor: Monitoring volatile organic compounds with naked eye, Talanta, 158, 57, 10.1016\u002Fj.talanta.2016.05.048",{"doi":7603},"10.1016\u002Fj.talanta.2016.05.048",{"id":21,"text":7605,"url":21,"identifiers":7606},"Lee, H.J., Park, K.K., Kupnik, M., Oralkan, O., and Khuri-Yakub, B.T. (2010, January 1–4). Highly sensitive detection of DMMP using a CMUT-based chemical sensor. Proceedings of the Sensors, Kona, HI, USA.",{"doi":7607},"10.1109\u002FICSENS.2010.5690493",{"id":21,"text":7609,"url":21,"identifiers":7610},"Kwon, 2016, Carboxylic Acid-Functionalized Conducting-Polymer Nanotubes as Highly Sensitive Nerve-Agent Chemiresistors, Sci. Rep., 6, 33724, 10.1038\u002Fsrep33724",{"doi":7611},"10.1038\u002Fsrep33724",{"id":21,"text":7613,"url":21,"identifiers":7614},"Cavallo, 2016, Functionalized polyanilines made by nucleophilic addition reaction, applied in gas sensors field, Synth. Met., 215, 127, 10.1016\u002Fj.synthmet.2016.02.013",{"doi":7615},"10.1016\u002Fj.synthmet.2016.02.013",{"id":21,"text":7617,"url":21,"identifiers":7618},"Krichevsky, 2016, A low-symmetrical zinc phthalocyanine-based Langmuir-Blodgett thin films for NO2 gas sensor applications, J. Phys. Conf. Ser., 737, 012030, 10.1088\u002F1742-6596\u002F737\u002F1\u002F012030",{"doi":7619},"10.1088\u002F1742-6596\u002F737\u002F1\u002F012030",{"id":21,"text":7621,"url":21,"identifiers":7622},"Akiyama, 2016, A sensor array based on trigonal-selenium nanowires for the detection of gas mixtures, Sens. Actuators B Chem., 223, 131, 10.1016\u002Fj.snb.2015.09.043",{"doi":7623},"10.1016\u002Fj.snb.2015.09.043",{"id":21,"text":7625,"url":21,"identifiers":7626},"Ma, 2017, The study on methane sensing with high-temperature low-power CMOS compatible silicon microheater, Sens. Actuators B Chem., 244, 17, 10.1016\u002Fj.snb.2016.12.115",{"doi":7627},"10.1016\u002Fj.snb.2016.12.115",{"id":21,"text":7629,"url":21,"identifiers":7630},"Puigcorb, 2003, High temperature degradation of Pt\u002FTi electrodes in micro-hotplate gas sensors, J. Micromech. Microeng., 13, S119, 10.1088\u002F0960-1317\u002F13\u002F4\u002F320",{"doi":7631},"10.1088\u002F0960-1317\u002F13\u002F4\u002F320",{"id":21,"text":7633,"url":21,"identifiers":7634},"Karpov, 2013, Energy efficient planar catalytic sensor for methane measurement, Sens. Actuators A Phys., 194, 176, 10.1016\u002Fj.sna.2013.01.057",{"doi":7635},"10.1016\u002Fj.sna.2013.01.057",{"id":21,"text":7637,"url":21,"identifiers":7638},"Asgharian, 2014, Computational modeling of nanoscale and microscale particle deposition, retention and dosimetry in the mouse respiratory tract, Inhal. Toxicol., 26, 829, 10.3109\u002F08958378.2014.935535",{"doi":7639},"10.3109\u002F08958378.2014.935535",{"id":21,"text":7641,"url":21,"identifiers":7642},"Nichols, 2014, Modeling the lung: Design and development of tissue engineered macro- and micro-physiologic lung models for research use, Exp. Biol. Med. (Maywood), 239, 1135, 10.1177\u002F1535370214536679",{"doi":7643},"10.1177\u002F1535370214536679",{"id":21,"text":7645,"url":21,"identifiers":7646},"Geiser, 2010, Deposition and biokinetics of inhaled nanoparticles, Part. Fibre Toxicol., 7, 2, 10.1186\u002F1743-8977-7-2",{"doi":7647},"10.1186\u002F1743-8977-7-2",{"id":21,"text":7649,"url":21,"identifiers":7650},"Nalayanda, 2010, Engineering an artificial alveolar-capillary membrane: A novel continuously perfused model within microchannels, J. Pediatr. Surg., 45, 45, 10.1016\u002Fj.jpedsurg.2009.10.008",{"doi":7651},"10.1016\u002Fj.jpedsurg.2009.10.008",{"id":21,"text":7653,"url":21,"identifiers":7654},"Benam, 2016, Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro, Nat. Methods, 13, 151, 10.1038\u002Fnmeth.3697",{"doi":7655},"10.1038\u002Fnmeth.3697",{"id":21,"text":7657,"url":21,"identifiers":7658},"Punde, 2015, A biologically inspired lung-on-a-chip device for the study of protein-induced lung inflammation, Integr. Biol., 7, 162, 10.1039\u002Fc4ib00239c",{"doi":7659},"10.1039\u002Fc4ib00239c",{"id":21,"text":7661,"url":21,"identifiers":7662},"Sellgren, 2014, A biomimetic multicellular model of the airways using primary human cells, Lab Chip, 14, 3349, 10.1039\u002FC4LC00552J",{"doi":7663},"10.1039\u002FC4LC00552J",{"id":21,"text":7665,"url":21,"identifiers":7666},"Huh, 2010, Reconstituting Organ-Level Lung Functions on a Chip, Science, 328, 1662, 10.1126\u002Fscience.1188302",{"doi":7667},"10.1126\u002Fscience.1188302",{"id":21,"text":7669,"url":21,"identifiers":7670},"Waters, 2012, Mechanobiology in lung epithelial cells: Measurements, perturbations, and responses, Compr. Phys., 2, 1",{},{"id":21,"text":7672,"url":21,"identifiers":7673},"Stucki, 2015, A lung-on-a-chip array with an integrated bio-inspired respiration mechanism, Lab Chip, 15, 1302, 10.1039\u002FC4LC01252F",{"doi":7674},"10.1039\u002FC4LC01252F",{"id":21,"text":7676,"url":21,"identifiers":7677},"Douville, 2011, Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model, Lab Chip, 11, 609, 10.1039\u002FC0LC00251H",{"doi":7678},"10.1039\u002FC0LC00251H",{"id":21,"text":7680,"url":21,"identifiers":7681},"Nesmith, 2014, Human airway musculature on a chip: An in vitro model of allergic asthmatic bronchoconstriction and bronchodilation, Lab Chip, 14, 3925, 10.1039\u002FC4LC00688G",{"doi":7682},"10.1039\u002FC4LC00688G",{"id":21,"text":7684,"url":21,"identifiers":7685},"Skolimowski, 2012, Modular microfluidic system as a model of cystic fibrosis airways, Biomicrofluidics, 6, 34109, 10.1063\u002F1.4742911",{"doi":7686},"10.1063\u002F1.4742911",{"id":21,"text":7688,"url":21,"identifiers":7689},"Tavana, 2011, Epithelium damage and protection during reopening of occluded airways in a physiologic microfluidic pulmonary airway model, Biomed. Microdevices, 13, 731, 10.1007\u002Fs10544-011-9543-5",{"doi":7690},"10.1007\u002Fs10544-011-9543-5",{"id":21,"text":7692,"url":21,"identifiers":7693},"Huh, 2012, A Human Disease Model of Drug Toxicity-Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice, Sci. Transl. Med., 4, ARTN, 10.1126\u002Fscitranslmed.3004249",{"doi":7694},"10.1126\u002Fscitranslmed.3004249",{"id":21,"text":7696,"url":21,"identifiers":7697},"Morrow, 1988, Possible mechanisms to explain dust overloading of the lungs, Fundam. Appl. Toxicol., 10, 369, 10.1016\u002F0272-0590(88)90284-9",{"doi":7698},"10.1016\u002F0272-0590(88)90284-9",{"id":21,"text":7700,"url":21,"identifiers":7701},"Pope, 2002, Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution, JAMA, 287, 1132, 10.1001\u002Fjama.287.9.1132",{"doi":7702},"10.1001\u002Fjama.287.9.1132",{"id":21,"text":7704,"url":21,"identifiers":7705},"Zhang, 2016, The movement and deposition of PM2.5 in the upper respiratory tract for the patients with heart failure: An elementary CFD study, Biomed. Eng. Online, 15, 138, 10.1186\u002Fs12938-016-0281-z",{"doi":7706},"10.1186\u002Fs12938-016-0281-z",{"id":21,"text":7708,"url":21,"identifiers":7709},"Schins, 2004, Inflammatory effects of coarse and fine particulate matter in relation to chemical and biological constituents, Toxicol. Appl. Pharmacol., 195, 1, 10.1016\u002Fj.taap.2003.10.002",{"doi":7710},"10.1016\u002Fj.taap.2003.10.002",{"id":21,"text":7712,"url":21,"identifiers":7713},"Lewtas, 2007, Air pollution combustion emissions: Characterization of causative agents and mechanisms associated with cancer, reproductive, and cardiovascular effects, Mutat. Res., 636, 95, 10.1016\u002Fj.mrrev.2007.08.003",{"doi":7714},"10.1016\u002Fj.mrrev.2007.08.003",{"id":21,"text":7716,"url":21,"identifiers":7717},"Dagher, 2006, Activation of different pathways of apoptosis by air pollution particulate matter (PM2.5) in human epithelial lung cells (L132) in culture, Toxicology, 225, 12, 10.1016\u002Fj.tox.2006.04.038",{"doi":7718},"10.1016\u002Fj.tox.2006.04.038",{"id":21,"text":7720,"url":21,"identifiers":7721},"Deng, 2013, PM2.5-induced oxidative stress triggers autophagy in human lung epithelial A549 cells, Toxicol In Vitro, 27, 1762, 10.1016\u002Fj.tiv.2013.05.004",{"doi":7722},"10.1016\u002Fj.tiv.2013.05.004",{"id":21,"text":7724,"url":21,"identifiers":7725},"Mahalingaiah, 2014, Air pollution and risk of uterine leiomyomata, Epidemiology, 25, 682, 10.1097\u002FEDE.0000000000000126",{"doi":7726},"10.1097\u002FEDE.0000000000000126",{"id":21,"text":7728,"url":21,"identifiers":7729},"Nursan, 2014, Parent’s knowledge and perceptions of the health effects of environmental hazards in Sakarya, Turkey, J. Pak. Med. Assoc., 64, 38",{},{"id":21,"text":7731,"url":21,"identifiers":7732},"Puett, 2014, Particulate matter air pollution exposure, distance to road, and incident lung cancer in the nurses’ health study cohort, Environ. Health Perspect., 122, 926, 10.1289\u002Fehp.1307490",{"doi":7733},"10.1289\u002Fehp.1307490",{"id":21,"text":7735,"url":21,"identifiers":7736},"Billet, 2008, Genotoxic potential of Polycyclic Aromatic Hydrocarbons-coated onto airborne Particulate Matter (PM 2.5) in human lung epithelial A549 cells, Cancer Lett., 270, 144, 10.1016\u002Fj.canlet.2008.04.044",{"doi":7737},"10.1016\u002Fj.canlet.2008.04.044",{"id":21,"text":7739,"url":21,"identifiers":7740},"Travis, W.D., Brambilla, E., Burke, A.P., Marx, A., and Nicholson, A.G. (2015). WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart, International Agency for Research on Cancer. [4th ed.].",{},{"id":21,"text":7742,"url":21,"identifiers":7743},"Socinski, 2004, Clinical issues in the management of non-small-cell lung cancer and the role of platinum-based therapy, Clin. Lung Cancer, 5, 274, 10.3816\u002FCLC.2004.n.007",{"doi":7744},"10.3816\u002FCLC.2004.n.007",{"id":21,"text":7746,"url":21,"identifiers":7747},"Hensing, 2003, The impact of age on toxicity, response rate, quality of life, and survival in patients with advanced, Stage IIIB or IV nonsmall cell lung carcinoma treated with carboplatin and paclitaxel, Cancer, 98, 779, 10.1002\u002Fcncr.11548",{"doi":7748},"10.1002\u002Fcncr.11548",{"id":21,"text":7750,"url":21,"identifiers":7751},"Culy, 2002, Gefitinib, Drugs, 62, 2237, 10.2165\u002F00003495-200262150-00008",{"doi":7752},"10.2165\u002F00003495-200262150-00008",{"id":21,"text":7754,"url":21,"identifiers":7755},"Su, 2011, Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha, J. Ethnopharmacol., 134, 251, 10.1016\u002Fj.jep.2010.12.003",{"doi":7756},"10.1016\u002Fj.jep.2010.12.003",{"id":21,"text":7758,"url":21,"identifiers":7759},"Anderson, M. (2015). As the Wind Blows: The Effects of Long-Term Exposure to Air Pollution on Mortality. NBEI Working Pap. Ser., 21578.",{"doi":7760},"10.3386\u002Fw21578",{"id":7762,"createTime":7763,"updateTime":7763,"relativeEntities":7764,"slug":7765,"properties":7766,"entityType":964,"verifyStatus":121,"verifyTime":7763,"verifyNote":1071,"languages":7781,"translateLanguages":21,"viewCount":22,"primaryUrl":7782,"fullTextUrl":21,"authors":7783,"publicationType":991,"publisherRelationship":7822,"citationCount":700,"citationInfo":7874,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":7876,"openAccess":21,"references":7877,"isForceReanalyzing":1050},"615a5f89-29cf-47c8-a78b-a0538e9b4d3a","2024-08-09T08:24:49.662+00:00",[],"At-the-Beginning-of-the-End-and-in-the-Middle-of-the-Beginning-Structure-and-Maintenance-of-Telomeric-DNA-Repeats-and-Interstitial-Telomeric-Sequences",{"mag":7767,"pmc":7769,"openalex":7771,"abstract":7773,"title":7775,"pm":7777,"doi":7779},{"VOID":7768},"2912710546",{"VOID":7770},"6410037",{"VOID":7772},"W2912710546",{"EN":7774},"\u003Cjats:p>Tandem DNA repeats derived from the ancestral (TTAGGG)n run were first detected at chromosome ends of the majority of living organisms, hence the name telomeric DNA repeats. Subsequently, it has become clear that telomeric motifs are also present within chromosomes, and they were suitably called interstitial telomeric sequences (ITSs). It is well known that telomeric DNA repeats play a key role in chromosome stability, preventing end-to-end fusions and precluding the recurrent DNA loss during replication. Recent data suggest that ITSs are also important genomic elements as they confer its karyotype plasticity. In fact, ITSs appeared to be among the most unstable microsatellite sequences as they are highly length polymorphic and can trigger chromosomal fragility and gross chromosomal rearrangements. Importantly, mechanisms responsible for their instability appear to be similar to the mechanisms that maintain the length of genuine telomeres. This review compares the mechanisms of maintenance and dynamic properties of telomeric repeats and ITSs and discusses the implications of these dynamics on genome stability.\u003C\u002Fjats:p>",{"EN":7776},"At the Beginning of the End and in the Middle of the Beginning: Structure and Maintenance of Telomeric DNA Repeats and Interstitial Telomeric Sequences",{"VOID":7778},"30764567",{"VOID":7780},"10.3390\u002Fgenes10020118",[125],"https:\u002F\u002Fwww.mdpi.com\u002F2073-4425\u002F10\u002F2\u002F118",[7784,7803],{"id":7785,"sortIndex":22,"researcher":21,"roles":7786,"affiliations":7787,"properties":7796,"displayName":7800,"givenName":21,"familyName":21},"6c2c8844-f356-4816-ad1e-aeba17a4f646",[],[7788],{"id":7789,"sortIndex":22,"affiliation":7790,"properties":21},"e2c47e61-e7dd-4743-aa98-f04a1e836415",{"id":7789,"createTime":21,"updateTime":21,"relativeEntities":7791,"slug":21,"properties":7792,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":7795,"statistic":21},[],{"title":7793},{"EN":7794},"Laboratory of Amyloid Biology, St. Petersburg State University, 199034 St. Petersburg, Russia",[],{"orcid":7797,"title":7799,"openalex":7801},{"VOID":7798},"https:\u002F\u002Forcid.org\u002F0000-0002-1601-1615",{"EN":7800},"Anna Y. Aksenova",{"VOID":7802},"A5003521011",{"id":7804,"sortIndex":93,"researcher":21,"roles":7805,"affiliations":7806,"properties":7815,"displayName":7819,"givenName":21,"familyName":21},"4cec352f-bf2f-467b-b1bd-18834d34ab19",[],[7807],{"id":7808,"sortIndex":22,"affiliation":7809,"properties":21},"18ea0d6c-7aa6-47ec-ae99-aab24bae84b4",{"id":7808,"createTime":21,"updateTime":21,"relativeEntities":7810,"slug":21,"properties":7811,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":7814,"statistic":21},[],{"title":7812},{"VI":7813},"Department of Biology, Tufts University, Medford, MA 02421, USA",[],{"orcid":7816,"title":7818,"openalex":7820},{"VOID":7817},"https:\u002F\u002Forcid.org\u002F0000-0003-4576-7582",{"EN":7819},"Sergei M. 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Net, 13, 181",{},{"id":21,"text":7882,"url":21,"identifiers":7883},"McClintock, 1938, The fusion of broken ends of sister half chromatids following chromatid breakage at meiotic anaphase, Miss. Agric. Exp. Stn. Res. Bull, 190, 1",{},{"id":21,"text":7885,"url":21,"identifiers":7886},"Muller, 1941, Induced mutations in Drosophila, Cold Spring Harb. Symp. Quant. Biol., 9, 151, 10.1101\u002FSQB.1941.009.01.019",{"doi":7887},"10.1101\u002FSQB.1941.009.01.019",{"id":21,"text":7889,"url":21,"identifiers":7890},"McClintock, 1941, The stability of broken ends of chromosomes in Zea Mays, Genetics, 26, 234, 10.1093\u002Fgenetics\u002F26.2.234",{"doi":7891},"10.1093\u002Fgenetics\u002F26.2.234",{"id":21,"text":7893,"url":21,"identifiers":7894},"Watson, 1972, Origin of Concatemeric T7 DNA, Nat. New Biol., 239, 197, 10.1038\u002Fnewbio239197a0",{"doi":7895},"10.1038\u002Fnewbio239197a0",{"id":21,"text":7897,"url":21,"identifiers":7898},"Olovnikov, 1973, A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon, J. Theor. Biol., 41, 181, 10.1016\u002F0022-5193(73)90198-7",{"doi":7899},"10.1016\u002F0022-5193(73)90198-7",{"id":21,"text":7901,"url":21,"identifiers":7902},"Greider, 1985, Identification of a specific telomere terminal transferase activity in Tetrahymena extracts, Cell, 43, 405, 10.1016\u002F0092-8674(85)90170-9",{"doi":7903},"10.1016\u002F0092-8674(85)90170-9",{"id":21,"text":7905,"url":21,"identifiers":7906},"Lundblad, 1993, An alternative pathway for yeast telomere maintenance rescues est1-senescence, Cell, 73, 347, 10.1016\u002F0092-8674(93)90234-H",{"doi":7907},"10.1016\u002F0092-8674(93)90234-H",{"id":21,"text":7909,"url":21,"identifiers":7910},"Zakian, 1995, Telomeres: Beginning to understand the end, Science, 270, 1601, 10.1126\u002Fscience.270.5242.1601",{"doi":7911},"10.1126\u002Fscience.270.5242.1601",{"id":21,"text":7913,"url":21,"identifiers":7914},"Wellinger, 1997, The DNA structures at the ends of eukaryotic chromosomes, Eur. J. Cancer, 33, 735, 10.1016\u002FS0959-8049(97)00067-1",{"doi":7915},"10.1016\u002FS0959-8049(97)00067-1",{"id":21,"text":7917,"url":21,"identifiers":7918},"Gomes, 2010, Telomere biology in Metazoa, FEBS Lett., 584, 3741, 10.1016\u002Fj.febslet.2010.07.031",{"doi":7919},"10.1016\u002Fj.febslet.2010.07.031",{"id":21,"text":7921,"url":21,"identifiers":7922},"Traut, 2005, The evolutionary origin of insect telomeric repeats, (TTAGG) N, Chromosom. Res., 13, 145, 10.1007\u002Fs10577-005-7721-0",{"doi":7923},"10.1007\u002Fs10577-005-7721-0",{"id":21,"text":7925,"url":21,"identifiers":7926},"Grossmann, 2004, Phylogenetic distribution of TTAGG telomeric repeats in insects, Genome, 47, 163, 10.1139\u002Fg03-100",{"doi":7927},"10.1139\u002Fg03-100",{"id":21,"text":7929,"url":21,"identifiers":7930},"Fuchs, 1995, Telomere sequence localization and karyotype evolution in higher plants, Plant Syst. Evol., 196, 227, 10.1007\u002FBF00982962",{"doi":7931},"10.1007\u002FBF00982962",{"id":21,"text":7933,"url":21,"identifiers":7934},"Fajkus, 2016, Telomere- and Telomerase-Associated Proteins and Their Functions in the Plant Cell, Front. Plant Sci., 7, 851",{},{"id":21,"text":7936,"url":21,"identifiers":7937},"Delany, 2003, Telomeres in the chicken: Genome stability and chromosome ends, Poult. Sci., 82, 917, 10.1093\u002Fps\u002F82.6.917",{"doi":7938},"10.1093\u002Fps\u002F82.6.917",{"id":21,"text":7940,"url":21,"identifiers":7941},"Wellinger, 2012, Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: Beginning to end, Genetics, 191, 1073, 10.1534\u002Fgenetics.111.137851",{"doi":7942},"10.1534\u002Fgenetics.111.137851",{"id":21,"text":7944,"url":21,"identifiers":7945},"Makarov, 1997, Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening, Cell, 88, 657, 10.1016\u002FS0092-8674(00)81908-X",{"doi":7946},"10.1016\u002FS0092-8674(00)81908-X",{"id":21,"text":7948,"url":21,"identifiers":7949},"Wright, 1997, Normal human chromosomes have long G-rich telomeric overhangs at one end, Genes Dev., 11, 2801, 10.1101\u002Fgad.11.21.2801",{"doi":7950},"10.1101\u002Fgad.11.21.2801",{"id":21,"text":7952,"url":21,"identifiers":7953},"Zhao, 2008, Quantitative telomeric overhang determination using a double-strand specific nuclease, Nucleic Acids Res., 36, e14, 10.1093\u002Fnar\u002Fgkm1063",{"doi":7954},"10.1093\u002Fnar\u002Fgkm1063",{"id":21,"text":7956,"url":21,"identifiers":7957},"Yang, T.-L.B., Song, S., and Johnson, F.B. (2016). Contributions of telomere biology to human age-related disease. Handbook of the Biology of Aging, Elsevier.",{"doi":7958},"10.1016\u002FB978-0-12-411596-5.00007-1",{"id":21,"text":7960,"url":21,"identifiers":7961},"Traverse, 1988, A spontaneously opened ring chromosome of Drosophila melanogaster has acquired He-T DNA sequences at both new telomeres, Proc. Natl. Acad. Sci. USA, 85, 8116, 10.1073\u002Fpnas.85.21.8116",{"doi":7962},"10.1073\u002Fpnas.85.21.8116",{"id":21,"text":7964,"url":21,"identifiers":7965},"Levis, 1993, Transposons in place of telomeric repeats at a Drosophila telomere, Cell, 75, 1083, 10.1016\u002F0092-8674(93)90318-K",{"doi":7966},"10.1016\u002F0092-8674(93)90318-K",{"id":21,"text":7968,"url":21,"identifiers":7969},"Nielsen, 1996, Terminal long tandem repeats in chromosomes form Chironomus pallidivittatus, Mol. Cell. Biol., 16, 3285, 10.1128\u002FMCB.16.7.3285",{"doi":7970},"10.1128\u002FMCB.16.7.3285",{"id":21,"text":7972,"url":21,"identifiers":7973},"Villasante, 2007, Drosophila telomeric retrotransposons derived from an ancestral element that was recruited to replace telomerase, Genome Res., 17, 1909, 10.1101\u002Fgr.6365107",{"doi":7974},"10.1101\u002Fgr.6365107",{"id":21,"text":7976,"url":21,"identifiers":7977},"Anzai, 2001, Sequence-specific recognition and cleavage of telomeric repeat (TTAGG)n by endonuclease of non-long terminal repeat retrotransposon TRAS1, Mol. Cell. Biol., 21, 100, 10.1128\u002FMCB.21.1.100-108.2001",{"doi":7978},"10.1128\u002FMCB.21.1.100-108.2001",{"id":21,"text":7980,"url":21,"identifiers":7981},"Fujiwara, 2011, Coevolution of telomeric repeats and telomeric repeat-specific non-LTR retrotransposons in insects, Mol. Biol. Evol., 28, 2983, 10.1093\u002Fmolbev\u002Fmsr135",{"doi":7982},"10.1093\u002Fmolbev\u002Fmsr135",{"id":21,"text":7984,"url":21,"identifiers":7985},"Henderson, 1987, Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine·guanine base pairs, Cell, 51, 899, 10.1016\u002F0092-8674(87)90577-0",{"doi":7986},"10.1016\u002F0092-8674(87)90577-0",{"id":21,"text":7988,"url":21,"identifiers":7989},"Williamson, 1989, Monovalent cation-induced structure of telomeric DNA: The G-quartet model, Cell, 59, 871, 10.1016\u002F0092-8674(89)90610-7",{"doi":7990},"10.1016\u002F0092-8674(89)90610-7",{"id":21,"text":7992,"url":21,"identifiers":7993},"Sundquist, 1989, Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops, Nature, 342, 825, 10.1038\u002F342825a0",{"doi":7994},"10.1038\u002F342825a0",{"id":21,"text":7996,"url":21,"identifiers":7997},"Wang, 1993, Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex, Structure, 1, 263, 10.1016\u002F0969-2126(93)90015-9",{"doi":7998},"10.1016\u002F0969-2126(93)90015-9",{"id":21,"text":8000,"url":21,"identifiers":8001},"Parkinson, 2002, Crystal structure of parallel quadruplexes from human telomeric DNA, Nature, 417, 876, 10.1038\u002Fnature755",{"doi":8002},"10.1038\u002Fnature755",{"id":21,"text":8004,"url":21,"identifiers":8005},"Chen, Y., and Yang, D. (2012). Sequence, stability, and structure of G-quadruplexes and their interactions with drugs. Current Protocols in Nucleic Acid Chemistry, John Wiley & Sons, Inc.",{"doi":8006},"10.1002\u002F0471142700.nc1705s50",{"id":21,"text":8008,"url":21,"identifiers":8009},"Zahler, 1991, Inhibition of telomerase by G-quartet DMA structures, Nature, 350, 718, 10.1038\u002F350718a0",{"doi":8010},"10.1038\u002F350718a0",{"id":21,"text":8012,"url":21,"identifiers":8013},"Smith, 2011, Rudimentary G-quadruplex–based telomere capping in Saccharomyces cerevisiae, Nat. Struct. Mol. Biol., 18, 478, 10.1038\u002Fnsmb.2033",{"doi":8014},"10.1038\u002Fnsmb.2033",{"id":21,"text":8016,"url":21,"identifiers":8017},"Sen, 1988, Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis, Nature, 334, 364, 10.1038\u002F334364a0",{"doi":8018},"10.1038\u002F334364a0",{"id":21,"text":8020,"url":21,"identifiers":8021},"Schaffitzel, 2001, In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei, Proc. Natl. Acad. Sci. USA, 98, 8572, 10.1073\u002Fpnas.141229498",{"doi":8022},"10.1073\u002Fpnas.141229498",{"id":21,"text":8024,"url":21,"identifiers":8025},"Biffi, 2013, Quantitative visualization of DNA G-quadruplex structures in human cells, Nat. Chem., 5, 182, 10.1038\u002Fnchem.1548",{"doi":8026},"10.1038\u002Fnchem.1548",{"id":21,"text":8028,"url":21,"identifiers":8029},"Lam, 2013, G-quadruplex structures are stable and detectable in human genomic DNA, Nat. Commun., 4, 1796, 10.1038\u002Fncomms2792",{"doi":8030},"10.1038\u002Fncomms2792",{"id":21,"text":8032,"url":21,"identifiers":8033},"Paeschke, 2011, DNA Replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase, Cell, 145, 678, 10.1016\u002Fj.cell.2011.04.015",{"doi":8034},"10.1016\u002Fj.cell.2011.04.015",{"id":21,"text":8036,"url":21,"identifiers":8037},"Marsh, 1962, IUCr The crystal structure of cytosine-5-acetic acid, Acta Crystallogr., 15, 310, 10.1107\u002FS0365110X62000791",{"doi":8038},"10.1107\u002FS0365110X62000791",{"id":21,"text":8040,"url":21,"identifiers":8041},"Gehring, 1993, A tetrameric DNA structure with protonated cytosine-cytosine base pairs, Nature, 363, 561, 10.1038\u002F363561a0",{"doi":8042},"10.1038\u002F363561a0",{"id":21,"text":8044,"url":21,"identifiers":8045},"Day, 2014, i-Motif DNA: Structure, stability and targeting with ligands, Bioorg. Med. Chem., 22, 4407, 10.1016\u002Fj.bmc.2014.05.047",{"doi":8046},"10.1016\u002Fj.bmc.2014.05.047",{"id":21,"text":8048,"url":21,"identifiers":8049},"Griffith, 1999, Mammalian telomeres end in a large duplex loop, Cell, 97, 503, 10.1016\u002FS0092-8674(00)80760-6",{"doi":8050},"10.1016\u002FS0092-8674(00)80760-6",{"id":21,"text":8052,"url":21,"identifiers":8053},"Hecht, 1997, SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast, Genes Dev., 11, 83, 10.1101\u002Fgad.11.1.83",{"doi":8054},"10.1101\u002Fgad.11.1.83",{"id":21,"text":8056,"url":21,"identifiers":8057},"Zaman, 2001, Telomere looping permits gene activation by a downstream UAS in yeast, Nature, 409, 109, 10.1038\u002F35051119",{"doi":8058},"10.1038\u002F35051119",{"id":21,"text":8060,"url":21,"identifiers":8061},"Poschke, 2012, Getting in (and out of) the loop: Regulating higher order telomere structures, Front. Oncol., 2, 180",{},{"id":21,"text":8063,"url":21,"identifiers":8064},"Kupiec, 2014, Biology of telomeres: Lessons from budding yeast, FEMS Microbiol. Rev., 38, 144, 10.1111\u002F1574-6976.12054",{"doi":8065},"10.1111\u002F1574-6976.12054",{"id":21,"text":8067,"url":21,"identifiers":8068},"Ceccaldi, 2016, Repair pathway choices and consequences at the double-strand break, Trends Cell Biol., 26, 52, 10.1016\u002Fj.tcb.2015.07.009",{"doi":8069},"10.1016\u002Fj.tcb.2015.07.009",{"id":21,"text":8071,"url":21,"identifiers":8072},"Kramara, 2018, Break-induced replication: The where, the why, and the how, Trends Genet., 34, 518, 10.1016\u002Fj.tig.2018.04.002",{"doi":8073},"10.1016\u002Fj.tig.2018.04.002",{"id":21,"text":8075,"url":21,"identifiers":8076},"Heyer, 2015, Regulation of recombination and genomic maintenance, Cold Spring Harb. Perspect. Biol., 7, a016501, 10.1101\u002Fcshperspect.a016501",{"doi":8077},"10.1101\u002Fcshperspect.a016501",{"id":21,"text":8079,"url":21,"identifiers":8080},"Seol, 2018, Microhomology-mediated end joining: Good, bad and ugly, Mutat. Res. Mol. Mech. Mutagen., 809, 81, 10.1016\u002Fj.mrfmmm.2017.07.002",{"doi":8081},"10.1016\u002Fj.mrfmmm.2017.07.002",{"id":21,"text":8083,"url":21,"identifiers":8084},"Rodgers, 2016, Error-prone repair of DNA double-strand breaks, J. Cell. Physiol., 231, 15, 10.1002\u002Fjcp.25053",{"doi":8085},"10.1002\u002Fjcp.25053",{"id":21,"text":8087,"url":21,"identifiers":8088},"Broccoli, 1997, Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2, Nat. Genet., 17, 231, 10.1038\u002Fng1097-231",{"doi":8089},"10.1038\u002Fng1097-231",{"id":21,"text":8091,"url":21,"identifiers":8092},"Cesare, 2006, The basic domain of TRF2 directs binding to DNA junctions irrespective of the presence of TTAGGG repeats, J. Biol. Chem., 281, 37486, 10.1074\u002Fjbc.M608778200",{"doi":8093},"10.1074\u002Fjbc.M608778200",{"id":21,"text":8095,"url":21,"identifiers":8096},"Palm, 2008, How shelterin protects mammalian telomeres, Annu. Rev. Genet., 42, 301, 10.1146\u002Fannurev.genet.41.110306.130350",{"doi":8097},"10.1146\u002Fannurev.genet.41.110306.130350",{"id":21,"text":8099,"url":21,"identifiers":8100},"Feuerhahn, 2015, No DDRama at chromosome ends: TRF2 takes centre stage, Trends Biochem. Sci., 40, 275, 10.1016\u002Fj.tibs.2015.03.003",{"doi":8101},"10.1016\u002Fj.tibs.2015.03.003",{"id":21,"text":8103,"url":21,"identifiers":8104},"Gao, 2007, RPA-like proteins mediate yeast telomere function, Nat. Struct. Mol. Biol., 14, 208, 10.1038\u002Fnsmb1205",{"doi":8105},"10.1038\u002Fnsmb1205",{"id":21,"text":8107,"url":21,"identifiers":8108},"Miyake, 2009, RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway, Mol. Cell, 36, 193, 10.1016\u002Fj.molcel.2009.08.009",{"doi":8109},"10.1016\u002Fj.molcel.2009.08.009",{"id":21,"text":8111,"url":21,"identifiers":8112},"Surovtseva, 2009, Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes, Mol. Cell, 36, 207, 10.1016\u002Fj.molcel.2009.09.017",{"doi":8113},"10.1016\u002Fj.molcel.2009.09.017",{"id":21,"text":8115,"url":21,"identifiers":8116},"Wellinger, 2009, The CST complex and telomere maintenance: The exception becomes the rule, Mol. Cell, 36, 168, 10.1016\u002Fj.molcel.2009.10.001",{"doi":8117},"10.1016\u002Fj.molcel.2009.10.001",{"id":21,"text":8119,"url":21,"identifiers":8120},"Sun, 2009, Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres, Genes Dev., 23, 2900, 10.1101\u002Fgad.1851909",{"doi":8121},"10.1101\u002Fgad.1851909",{"id":21,"text":8123,"url":21,"identifiers":8124},"Bryan, C., Rice, C., Harkisheimer, M., Schultz, D.C., and Skordalakes, E. (2013). Structure of the human telomeric Stn1-Ten1 capping complex. PLoS ONE, 8.",{"doi":8125},"10.2210\u002Fpdb4joi\u002Fpdb",{"id":21,"text":8127,"url":21,"identifiers":8128},"Wan, 2015, The Tetrahymena telomerase p75–p45–p19 subcomplex is a unique CST complex, Nat. Struct. Mol. Biol., 22, 1023, 10.1038\u002Fnsmb.3126",{"doi":8129},"10.1038\u002Fnsmb.3126",{"id":21,"text":8131,"url":21,"identifiers":8132},"Rice, 2016, Structure and function of the telomeric CST complex, Comput. Struct. Biotechnol. J., 14, 161, 10.1016\u002Fj.csbj.2016.04.002",{"doi":8133},"10.1016\u002Fj.csbj.2016.04.002",{"id":21,"text":8135,"url":21,"identifiers":8136},"Murzin, 1993, OB(oligonucleotide\u002Foligosaccharide binding)-fold: Common structural and functional solution for non-homologous sequences, EMBO J., 12, 861, 10.1002\u002Fj.1460-2075.1993.tb05726.x",{"doi":8137},"10.1002\u002Fj.1460-2075.1993.tb05726.x",{"id":21,"text":8139,"url":21,"identifiers":8140},"Arcus, 2002, OB-fold domains: A snapshot of the evolution of sequence, structure and function, Curr. Opin. Struct. Biol., 12, 794, 10.1016\u002FS0959-440X(02)00392-5",{"doi":8141},"10.1016\u002FS0959-440X(02)00392-5",{"id":21,"text":8143,"url":21,"identifiers":8144},"Shore, 1994, RAP1: A protean regulator in yeast, Trends Genet., 10, 408, 10.1016\u002F0168-9525(94)90058-2",{"doi":8145},"10.1016\u002F0168-9525(94)90058-2",{"id":21,"text":8147,"url":21,"identifiers":8148},"Gilson, E., and Gasser, S.M. (1995). Repressor activator protein 1 and its ligands: organising chromatin domains. Nucleic Acids and Molecular Biology, Springer.",{"doi":8149},"10.1007\u002F978-3-642-79488-9_16",{"id":21,"text":8151,"url":21,"identifiers":8152},"Konig, 1996, The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA, Cell, 85, 125, 10.1016\u002FS0092-8674(00)81088-0",{"doi":8153},"10.1016\u002FS0092-8674(00)81088-0",{"id":21,"text":8155,"url":21,"identifiers":8156},"Taylor, 2000, How the multifunctional yeast Rap1p discriminates between DNA target sites: A crystallographic analysis, J. Mol. Biol., 303, 693, 10.1006\u002Fjmbi.2000.4161",{"doi":8157},"10.1006\u002Fjmbi.2000.4161",{"id":21,"text":8159,"url":21,"identifiers":8160},"Li, 2000, Identification of human Rap1: Implications for telomere evolution, Cell, 101, 471, 10.1016\u002FS0092-8674(00)80858-2",{"doi":8161},"10.1016\u002FS0092-8674(00)80858-2",{"id":21,"text":8163,"url":21,"identifiers":8164},"Safari, 2004, The human Rap1 protein complex and modulation of telomere length, J. Biol. Chem., 279, 28585, 10.1074\u002Fjbc.M312913200",{"doi":8165},"10.1074\u002Fjbc.M312913200",{"id":21,"text":8167,"url":21,"identifiers":8168},"Kabir, 2010, Taking apart Rap1: An adaptor protein with telomeric and non-telomeric functions, Cell Cycle, 9, 4061, 10.4161\u002Fcc.9.20.13579",{"doi":8169},"10.4161\u002Fcc.9.20.13579",{"id":21,"text":8171,"url":21,"identifiers":8172},"Sarthy, 2009, Human RAP1 inhibits non-homologous end joining at telomeres, EMBO J., 28, 3390, 10.1038\u002Femboj.2009.275",{"doi":8173},"10.1038\u002Femboj.2009.275",{"id":21,"text":8175,"url":21,"identifiers":8176},"Sfeir, 2010, Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal, Science, 327, 1657, 10.1126\u002Fscience.1185100",{"doi":8177},"10.1126\u002Fscience.1185100",{"id":21,"text":8179,"url":21,"identifiers":8180},"Martinez, 2010, Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites, Nat. Cell Biol., 12, 768, 10.1038\u002Fncb2081",{"doi":8181},"10.1038\u002Fncb2081",{"id":21,"text":8183,"url":21,"identifiers":8184},"Yeung, 2013, Nontelomeric role for Rap1 in regulating metabolism and protecting against obesity, Cell Rep., 3, 1847, 10.1016\u002Fj.celrep.2013.05.032",{"doi":8185},"10.1016\u002Fj.celrep.2013.05.032",{"id":21,"text":8187,"url":21,"identifiers":8188},"Teixeira, 2005, Telomere maintenance, function and evolution: The yeast paradigm, Chromosom. Res., 13, 535, 10.1007\u002Fs10577-005-0999-0",{"doi":8189},"10.1007\u002Fs10577-005-0999-0",{"id":21,"text":8191,"url":21,"identifiers":8192},"Brigati, 1993, An essential yeast gene encoding a TTAGGG repeat-binding protein, Mol. Cell. Biol., 13, 1306",{},{"id":21,"text":8194,"url":21,"identifiers":8195},"Koering, 2000, Identification of high affinity Tbf1p-binding sites within the budding yeast genome, Nucleic Acids Res., 28, 2519, 10.1093\u002Fnar\u002F28.13.2519",{"doi":8196},"10.1093\u002Fnar\u002F28.13.2519",{"id":21,"text":8198,"url":21,"identifiers":8199},"Liu, 1991, A yeast protein that binds to vertebrate telomeres and conserved yeast telomeric junctions, Genes Dev., 5, 49, 10.1101\u002Fgad.5.1.49",{"doi":8200},"10.1101\u002Fgad.5.1.49",{"id":21,"text":8202,"url":21,"identifiers":8203},"Fourel, 1999, Cohabitation of insulators and silencing elements in yeast subtelomeric regions, EMBO J., 18, 2522, 10.1093\u002Femboj\u002F18.9.2522",{"doi":8204},"10.1093\u002Femboj\u002F18.9.2522",{"id":21,"text":8206,"url":21,"identifiers":8207},"Gottschling, 1990, Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription, Cell, 63, 751, 10.1016\u002F0092-8674(90)90141-Z",{"doi":8208},"10.1016\u002F0092-8674(90)90141-Z",{"id":21,"text":8210,"url":21,"identifiers":8211},"Bilaud, 1996, The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human, Nucleic Acids Res., 24, 1294, 10.1093\u002Fnar\u002F24.7.1294",{"doi":8212},"10.1093\u002Fnar\u002F24.7.1294",{"id":21,"text":8214,"url":21,"identifiers":8215},"Brevet, 2003, The number of vertebrate repeats can be regulated at yeast telomeres by Rap1-independent mechanisms, EMBO J., 22, 1697, 10.1093\u002Femboj\u002Fcdg155",{"doi":8216},"10.1093\u002Femboj\u002Fcdg155",{"id":21,"text":8218,"url":21,"identifiers":8219},"Alexander, 2003, Rap1p telomere association is not required for mitotic stability of a C(3)TA(2) telomere in yeast, EMBO J., 22, 1688, 10.1093\u002Femboj\u002Fcdg154",{"doi":8220},"10.1093\u002Femboj\u002Fcdg154",{"id":21,"text":8222,"url":21,"identifiers":8223},"Ribaud, 2012, DNA-end capping by the budding yeast transcription factor and subtelomeric binding protein Tbf1, EMBO J., 31, 138, 10.1038\u002Femboj.2011.349",{"doi":8224},"10.1038\u002Femboj.2011.349",{"id":21,"text":8226,"url":21,"identifiers":8227},"Lingner, 2007, Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast, EMBO Rep., 8, 1080, 10.1038\u002Fsj.embor.7401082",{"doi":8228},"10.1038\u002Fsj.embor.7401082",{"id":21,"text":8230,"url":21,"identifiers":8231},"Preti, 2010, The telomere-binding protein Tbf1 demarcates snoRNA gene promoters in Saccharomyces cerevisiae, Mol. Cell, 38, 614, 10.1016\u002Fj.molcel.2010.04.016",{"doi":8232},"10.1016\u002Fj.molcel.2010.04.016",{"id":21,"text":8234,"url":21,"identifiers":8235},"Ichikawa, 2015, Nucleosome organization and chromatin dynamics in telomeres, Biomol. Concepts, 6, 67, 10.1515\u002Fbmc-2014-0035",{"doi":8236},"10.1515\u002Fbmc-2014-0035",{"id":21,"text":8238,"url":21,"identifiers":8239},"Ichikawa, 2014, Telomeric repeats act as nucleosome-disfavouring sequences in vivo, Nucleic Acids Res., 42, 1541, 10.1093\u002Fnar\u002Fgkt1006",{"doi":8240},"10.1093\u002Fnar\u002Fgkt1006",{"id":21,"text":8242,"url":21,"identifiers":8243},"Yarragudi, 2004, Comparison of ABF1 and RAP1 in chromatin opening and transactivator potentiation in the budding yeast Saccharomyces cerevisiae, Mol. Cell. Biol., 24, 9152, 10.1128\u002FMCB.24.20.9152-9164.2004",{"doi":8244},"10.1128\u002FMCB.24.20.9152-9164.2004",{"id":21,"text":8246,"url":21,"identifiers":8247},"Badis, 2008, A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters, Mol. Cell, 32, 878, 10.1016\u002Fj.molcel.2008.11.020",{"doi":8248},"10.1016\u002Fj.molcel.2008.11.020",{"id":21,"text":8250,"url":21,"identifiers":8251},"Kubik, 2018, Sequence-directed action of RSC remodeler and general regulatory factors modulates +1 nucleosome position to facilitate transcription, Mol. Cell, 71, 89, 10.1016\u002Fj.molcel.2018.05.030",{"doi":8252},"10.1016\u002Fj.molcel.2018.05.030",{"id":21,"text":8254,"url":21,"identifiers":8255},"Kaplan, 2009, The DNA-encoded nucleosome organization of a eukaryotic genome, Nature, 458, 362, 10.1038\u002Fnature07667",{"doi":8256},"10.1038\u002Fnature07667",{"id":21,"text":8258,"url":21,"identifiers":8259},"Ganapathi, 2011, Extensive role of the general regulatory factors, Abf1 and Rap1, in determining genome-wide chromatin structure in budding yeast, Nucleic Acids Res., 39, 2032, 10.1093\u002Fnar\u002Fgkq1161",{"doi":8260},"10.1093\u002Fnar\u002Fgkq1161",{"id":21,"text":8262,"url":21,"identifiers":8263},"Tsankov, 2011, Evolutionary divergence of intrinsic and trans-regulated nucleosome positioning sequences reveals plastic rules for chromatin organization, Genome Res., 21, 1851, 10.1101\u002Fgr.122267.111",{"doi":8264},"10.1101\u002Fgr.122267.111",{"id":21,"text":8266,"url":21,"identifiers":8267},"Struhl, 2013, Determinants of nucleosome positioning, Nat. Struct. Mol. Biol., 20, 267, 10.1038\u002Fnsmb.2506",{"doi":8268},"10.1038\u002Fnsmb.2506",{"id":21,"text":8270,"url":21,"identifiers":8271},"Van Bakel, H., Tsui, K., Gebbia, M., Mnaimneh, S., Hughes, T.R., and Nislow, C. (2013). A compendium of nucleosome and transcript profiles reveals determinants of chromatin architecture and transcription. PLoS Genet., 9.",{"doi":8272},"10.1371\u002Fjournal.pgen.1003479",{"id":21,"text":8274,"url":21,"identifiers":8275},"Kubik, 2015, Nucleosome stability distinguishes two different promoter types at all protein-coding genes in yeast, Mol. Cell, 60, 422, 10.1016\u002Fj.molcel.2015.10.002",{"doi":8276},"10.1016\u002Fj.molcel.2015.10.002",{"id":21,"text":8278,"url":21,"identifiers":8279},"Krietenstein, 2016, Genomic nucleosome organization reconstituted with pure proteins, Cell, 167, 709, 10.1016\u002Fj.cell.2016.09.045",{"doi":8280},"10.1016\u002Fj.cell.2016.09.045",{"id":21,"text":8282,"url":21,"identifiers":8283},"Yan, 2018, Systematic study of nucleosome-displacing factors in budding yeast, Mol. Cell, 71, 294, 10.1016\u002Fj.molcel.2018.06.017",{"doi":8284},"10.1016\u002Fj.molcel.2018.06.017",{"id":21,"text":8286,"url":21,"identifiers":8287},"Bonetti, 2013, Tbf1 and Vid22 promote resection and non-homologous end joining of DNA double-strand break ends, EMBO J., 32, 275, 10.1038\u002Femboj.2012.327",{"doi":8288},"10.1038\u002Femboj.2012.327",{"id":21,"text":8290,"url":21,"identifiers":8291},"Bi, 1999, UASrpg can function as a heterochromatin boundary element in yeast, Genes Dev., 13, 1089, 10.1101\u002Fgad.13.9.1089",{"doi":8292},"10.1101\u002Fgad.13.9.1089",{"id":21,"text":8294,"url":21,"identifiers":8295},"Bi, 2004, Formation of boundaries of transcriptionally silent chromatin by nucleosome-excluding structures, Mol. Cell. Biol., 24, 2118, 10.1128\u002FMCB.24.5.2118-2131.2004",{"doi":8296},"10.1128\u002FMCB.24.5.2118-2131.2004",{"id":21,"text":8298,"url":21,"identifiers":8299},"Donze, 2001, RNA polymerase III and RNA polymerase II promoter complexes are heterochromatin barriers in Saccharomyces cerevisiae, EMBO J., 20, 520, 10.1093\u002Femboj\u002F20.3.520",{"doi":8300},"10.1093\u002Femboj\u002F20.3.520",{"id":21,"text":8302,"url":21,"identifiers":8303},"Gartenberg, 2016, The nuts and bolts of transcriptionally silent chromatin in Saccharomyces cerevisiae, Genetics, 203, 1563, 10.1534\u002Fgenetics.112.145243",{"doi":8304},"10.1534\u002Fgenetics.112.145243",{"id":21,"text":8306,"url":21,"identifiers":8307},"Fourel, 2002, General regulatory factors (GRFs) as genome partitioners, J. Biol. Chem., 277, 41736, 10.1074\u002Fjbc.M202578200",{"doi":8308},"10.1074\u002Fjbc.M202578200",{"id":21,"text":8310,"url":21,"identifiers":8311},"Tommerup, 1994, Unusual chromatin in human telomeres, Mol. Cell. Biol., 14, 5777",{},{"id":21,"text":8313,"url":21,"identifiers":8314},"Tardat, 2018, Telomere chromatin establishment and its maintenance during mammalian development, Chromosoma, 127, 3, 10.1007\u002Fs00412-017-0656-3",{"doi":8315},"10.1007\u002Fs00412-017-0656-3",{"id":21,"text":8317,"url":21,"identifiers":8318},"Cubiles, 2018, Epigenetic features of human telomeres, Nucleic Acids Res., 46, 2347, 10.1093\u002Fnar\u002Fgky006",{"doi":8319},"10.1093\u002Fnar\u002Fgky006",{"id":21,"text":8321,"url":21,"identifiers":8322},"Ernst, 2011, Mapping and analysis of chromatin state dynamics in nine human cell types, Nature, 473, 43, 10.1038\u002Fnature09906",{"doi":8323},"10.1038\u002Fnature09906",{"id":21,"text":8325,"url":21,"identifiers":8326},"Rosenfeld, J.A., Wang, Z., Schones, D.E., Zhao, K., DeSalle, R., and Zhang, M.Q. (2009). Determination of enriched histone modifications in non-genic portions of the human genome. BMC Genom., 10.",{"doi":8327},"10.1186\u002F1471-2164-10-143",{"id":21,"text":8329,"url":21,"identifiers":8330},"Kubicek, 2010, Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres, Nat. Struct. Mol. Biol., 17, 1218, 10.1038\u002Fnsmb.1897",{"doi":8331},"10.1038\u002Fnsmb.1897",{"id":21,"text":8333,"url":21,"identifiers":8334},"2011, Arabidopsis thaliana telomeres exhibit euchromatic features, Nucleic Acids Res., 39, 2007, 10.1093\u002Fnar\u002Fgkq1119",{"doi":8335},"10.1093\u002Fnar\u002Fgkq1119",{"id":21,"text":8337,"url":21,"identifiers":8338},"Ivessa, 2002, Saccharomyces Rrm3p, a 5’ to 3’ DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA, Genes Dev., 16, 1383, 10.1101\u002Fgad.982902",{"doi":8339},"10.1101\u002Fgad.982902",{"id":21,"text":8341,"url":21,"identifiers":8342},"Makovets, 2004, Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions, Mol. Cell. Biol., 24, 4019, 10.1128\u002FMCB.24.9.4019-4031.2004",{"doi":8343},"10.1128\u002FMCB.24.9.4019-4031.2004",{"id":21,"text":8345,"url":21,"identifiers":8346},"Miller, 2006, Semi-conservative DNA replication through telomeres requires Taz1, Nature, 440, 824, 10.1038\u002Fnature04638",{"doi":8347},"10.1038\u002Fnature04638",{"id":21,"text":8349,"url":21,"identifiers":8350},"Sfeir, 2009, Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication, Cell, 138, 90, 10.1016\u002Fj.cell.2009.06.021",{"doi":8351},"10.1016\u002Fj.cell.2009.06.021",{"id":21,"text":8353,"url":21,"identifiers":8354},"Lopes, 2011, G-quadruplex-induced instability during leading-strand replication, EMBO J., 30, 4033, 10.1038\u002Femboj.2011.316",{"doi":8355},"10.1038\u002Femboj.2011.316",{"id":21,"text":8357,"url":21,"identifiers":8358},"Bah, 2011, Telomerase is required to protect chromosomes with vertebrate-type T2AG3 3’ ends in Saccharomyces cerevisiae, J. Biol. Chem., 286, 27132, 10.1074\u002Fjbc.M111.220186",{"doi":8359},"10.1074\u002Fjbc.M111.220186",{"id":21,"text":8361,"url":21,"identifiers":8362},"Anand, 2012, Overcoming natural replication barriers: Differential helicase requirements, Nucleic Acids Res., 40, 1091, 10.1093\u002Fnar\u002Fgkr836",{"doi":8363},"10.1093\u002Fnar\u002Fgkr836",{"id":21,"text":8365,"url":21,"identifiers":8366},"Lormand, 2013, DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation, Nucleic Acids Res., 41, 10323, 10.1093\u002Fnar\u002Fgkt813",{"doi":8367},"10.1093\u002Fnar\u002Fgkt813",{"id":21,"text":8369,"url":21,"identifiers":8370},"Geronimo, 2016, Getting it done at the ends: Pif1 family DNA helicases and telomeres, DNA Repair, 44, 151, 10.1016\u002Fj.dnarep.2016.05.021",{"doi":8371},"10.1016\u002Fj.dnarep.2016.05.021",{"id":21,"text":8373,"url":21,"identifiers":8374},"Croteau, 2014, Human RecQ helicases in DNA repair, recombination, and replication, Annu. Rev. Biochem., 83, 519, 10.1146\u002Fannurev-biochem-060713-035428",{"doi":8375},"10.1146\u002Fannurev-biochem-060713-035428",{"id":21,"text":8377,"url":21,"identifiers":8378},"Mendoza, 2016, G-quadruplexes and helicases, Nucleic Acids Res., 44, 1989, 10.1093\u002Fnar\u002Fgkw079",{"doi":8379},"10.1093\u002Fnar\u002Fgkw079",{"id":21,"text":8381,"url":21,"identifiers":8382},"Whitby, 2010, The FANCM family of DNA helicases\u002Ftranslocases, DNA Repair, 9, 224, 10.1016\u002Fj.dnarep.2009.12.012",{"doi":8383},"10.1016\u002Fj.dnarep.2009.12.012",{"id":21,"text":8385,"url":21,"identifiers":8386},"Vannier, 2014, RTEL1: Functions of a disease-associated helicase, Trends Cell Biol., 24, 416, 10.1016\u002Fj.tcb.2014.01.004",{"doi":8387},"10.1016\u002Fj.tcb.2014.01.004",{"id":21,"text":8389,"url":21,"identifiers":8390},"Poole, 2016, SMARCAL1 and telomeres: Replicating the troublesome ends, Nucleus, 7, 270, 10.1080\u002F19491034.2016.1179413",{"doi":8391},"10.1080\u002F19491034.2016.1179413",{"id":21,"text":8393,"url":21,"identifiers":8394},"Niu, 2016, Multifunctional roles of Saccharomyces cerevisiae Srs2 protein in replication, recombination and repair, FEMS Yeast Res., 17, fow111, 10.1093\u002Ffemsyr\u002Ffow111",{"doi":8395},"10.1093\u002Ffemsyr\u002Ffow111",{"id":21,"text":8397,"url":21,"identifiers":8398},"Bianchi, 2007, Early replication of short telomeres in budding yeast, Cell, 128, 1051, 10.1016\u002Fj.cell.2007.01.041",{"doi":8399},"10.1016\u002Fj.cell.2007.01.041",{"id":21,"text":8401,"url":21,"identifiers":8402},"Cooley, 2014, Protein phosphatase 1 recruitment by Rif1 regulates DNA replication origin firing by counteracting DDK activity, Cell Rep., 7, 53, 10.1016\u002Fj.celrep.2014.02.019",{"doi":8403},"10.1016\u002Fj.celrep.2014.02.019",{"id":21,"text":8405,"url":21,"identifiers":8406},"Hiraga, 2014, Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex, Genes Dev., 28, 372, 10.1101\u002Fgad.231258.113",{"doi":8407},"10.1101\u002Fgad.231258.113",{"id":21,"text":8409,"url":21,"identifiers":8410},"Mattarocci, 2014, Rif1 controls DNA replication timing in yeast through the PP1 phosphatase Glc7, Cell Rep., 7, 62, 10.1016\u002Fj.celrep.2014.03.010",{"doi":8411},"10.1016\u002Fj.celrep.2014.03.010",{"id":21,"text":8413,"url":21,"identifiers":8414},"Hafner, 2018, Rif1 binding and control of chromosome-internal DNA replication origins is limited by telomere sequestration, Cell Rep., 23, 983, 10.1016\u002Fj.celrep.2018.03.113",{"doi":8415},"10.1016\u002Fj.celrep.2018.03.113",{"id":21,"text":8417,"url":21,"identifiers":8418},"Hafner, L., Shore, D., and Mattarocci, S. (2018). ChECing out Rif1 action in freely cycling cells. Curr. Genet., 1–6.",{"doi":8419},"10.1007\u002Fs00294-018-0902-0",{"id":21,"text":8421,"url":21,"identifiers":8422},"Hiraga, 2018, Budding yeast Rif1 binds to replication origins and protects DNA at blocked replication forks, EMBO Rep., 19, e46222, 10.15252\u002Fembr.201846222",{"doi":8423},"10.15252\u002Fembr.201846222",{"id":21,"text":8425,"url":21,"identifiers":8426},"Arnoult, N., Schluth-Bolard, C., Letessier, A., Drascovic, I., Bouarich-Bourimi, R., Campisi, J., Kim, S., Boussouar, A., Ottaviani, A., and Magdinier, F. (2010). Replication timing of human telomeres is chromosome arm-specific, influenced by subtelomeric structures and connected to nuclear localization. PLoS Genet., 6.",{"doi":8427},"10.1371\u002Fjournal.pgen.1000920",{"id":21,"text":8429,"url":21,"identifiers":8430},"Azzalin, 2007, Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends, Science, 318, 798, 10.1126\u002Fscience.1147182",{"doi":8431},"10.1126\u002Fscience.1147182",{"id":21,"text":8433,"url":21,"identifiers":8434},"Schoeftner, 2008, Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II, Nat. Cell Biol., 10, 228, 10.1038\u002Fncb1685",{"doi":8435},"10.1038\u002Fncb1685",{"id":21,"text":8437,"url":21,"identifiers":8438},"Xu, 2010, Telomeric repeat-containing RNA structure in living cells, Proc. Natl. Acad. Sci. USA, 107, 14579, 10.1073\u002Fpnas.1001177107",{"doi":8439},"10.1073\u002Fpnas.1001177107",{"id":21,"text":8441,"url":21,"identifiers":8442},"Xu, 2008, G-quadruplex formation by human telomeric repeats-containing RNA in Na + solution, J. Am. Chem. Soc., 130, 11179, 10.1021\u002Fja8031532",{"doi":8443},"10.1021\u002Fja8031532",{"id":21,"text":8445,"url":21,"identifiers":8446},"Martadinata, 2009, Structure of propeller-type parallel-stranded RNA G-quadruplexes, formed by human telomeric RNA sequences in K + solution, J. Am. Chem. Soc., 131, 2570, 10.1021\u002Fja806592z",{"doi":8447},"10.1021\u002Fja806592z",{"id":21,"text":8449,"url":21,"identifiers":8450},"Collie, 2010, A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex, Nucleic Acids Res., 38, 5569, 10.1093\u002Fnar\u002Fgkq259",{"doi":8451},"10.1093\u002Fnar\u002Fgkq259",{"id":21,"text":8453,"url":21,"identifiers":8454},"Balk, 2013, Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence, Nat. Struct. Mol. Biol., 20, 1199, 10.1038\u002Fnsmb.2662",{"doi":8455},"10.1038\u002Fnsmb.2662",{"id":21,"text":8457,"url":21,"identifiers":8458},"Aguilera, 2015, R loops: New modulators of genome dynamics and function, Nat. Rev. Genet., 16, 583, 10.1038\u002Fnrg3961",{"doi":8459},"10.1038\u002Fnrg3961",{"id":21,"text":8461,"url":21,"identifiers":8462},"Gan, 2011, R-loop-mediated genomic instability is caused by impairment of replication fork progression, Genes Dev., 25, 2041, 10.1101\u002Fgad.17010011",{"doi":8463},"10.1101\u002Fgad.17010011",{"id":21,"text":8465,"url":21,"identifiers":8466},"Maicher, 2014, Breaking new ground: Digging into TERRA function, Biochim. Biophys. Acta, 1839, 387, 10.1016\u002Fj.bbagrm.2014.03.012",{"doi":8467},"10.1016\u002Fj.bbagrm.2014.03.012",{"id":21,"text":8469,"url":21,"identifiers":8470},"Arora, 2015, Telomere elongation chooses TERRA ALTernatives, RNA Biol., 12, 938, 10.1080\u002F15476286.2015.1065374",{"doi":8471},"10.1080\u002F15476286.2015.1065374",{"id":21,"text":8473,"url":21,"identifiers":8474},"Arora, 2014, RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells, Nat. Commun., 5, 5220, 10.1038\u002Fncomms6220",{"doi":8475},"10.1038\u002Fncomms6220",{"id":21,"text":8477,"url":21,"identifiers":8478},"Dilley, 2015, ALTernative telomere maintenance and cancer, Trends Cancer, 1, 145, 10.1016\u002Fj.trecan.2015.07.007",{"doi":8479},"10.1016\u002Fj.trecan.2015.07.007",{"id":21,"text":8481,"url":21,"identifiers":8482},"Cusanelli, 2013, Telomeric noncoding RNA TERRA is induced by telomere shortening to nucleate telomerase molecules at short telomeres, Mol. Cell, 51, 780, 10.1016\u002Fj.molcel.2013.08.029",{"doi":8483},"10.1016\u002Fj.molcel.2013.08.029",{"id":21,"text":8485,"url":21,"identifiers":8486},"Moravec, 2016, TERRA promotes telomerase-mediated telomere elongation in Schizosaccharomyces pombe, EMBO Rep., 17, 999, 10.15252\u002Fembr.201541708",{"doi":8487},"10.15252\u002Fembr.201541708",{"id":21,"text":8489,"url":21,"identifiers":8490},"Graf, 2017, Telomere length determines TERRA and R-Loop regulation through the cell cycle, Cell, 170, 72, 10.1016\u002Fj.cell.2017.06.006",{"doi":8491},"10.1016\u002Fj.cell.2017.06.006",{"id":21,"text":8493,"url":21,"identifiers":8494},"Deng, 2009, TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres, Mol. Cell, 35, 403, 10.1016\u002Fj.molcel.2009.06.025",{"doi":8495},"10.1016\u002Fj.molcel.2009.06.025",{"id":21,"text":8497,"url":21,"identifiers":8498},"Bah, 2012, The telomeric transcriptome: From fission yeast to mammals, Int. J. Biochem. Cell Biol., 44, 1055, 10.1016\u002Fj.biocel.2012.03.021",{"doi":8499},"10.1016\u002Fj.biocel.2012.03.021",{"id":21,"text":8501,"url":21,"identifiers":8502},"Rippe, 2015, TERRA and the state of the telomere, Nat. Struct. Mol. Biol., 22, 853, 10.1038\u002Fnsmb.3078",{"doi":8503},"10.1038\u002Fnsmb.3078",{"id":21,"text":8505,"url":21,"identifiers":8506},"Luke, 2008, The Rat1p 5’ to 3’ exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae, Mol. Cell, 32, 465, 10.1016\u002Fj.molcel.2008.10.019",{"doi":8507},"10.1016\u002Fj.molcel.2008.10.019",{"id":21,"text":8509,"url":21,"identifiers":8510},"Redon, 2010, The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase, Nucleic Acids Res., 38, 5797, 10.1093\u002Fnar\u002Fgkq296",{"doi":8511},"10.1093\u002Fnar\u002Fgkq296",{"id":21,"text":8513,"url":21,"identifiers":8514},"Farnung, B.O., Brun, C.M., Arora, R., Lorenzi, L.E., and Azzalin, C.M. (2012). Telomerase efficiently elongates highly transcribing telomeres in human cancer cells. PLoS ONE, 7.",{"doi":8515},"10.1371\u002Fjournal.pone.0035714",{"id":21,"text":8517,"url":21,"identifiers":8518},"Cusanelli, 2015, Telomeric repeat-containing RNA TERRA: A noncoding RNA connecting telomere biology to genome integrity, Front. Genet., 6, 143, 10.3389\u002Ffgene.2015.00143",{"doi":8519},"10.3389\u002Ffgene.2015.00143",{"id":21,"text":8521,"url":21,"identifiers":8522},"Vrbsky, J., Akimcheva, S., Watson, J.M., Turner, T.L., Daxinger, L., Vyskot, B., Aufsatz, W., and Riha, K. (2010). siRNA–mediated methylation of Arabidopsis telomeres. PLoS Genet., 6.",{"doi":8523},"10.1371\u002Fjournal.pgen.1000986",{"id":21,"text":8525,"url":21,"identifiers":8526},"Bah, 2012, The telomeric transcriptome of Schizosaccharomyces pombe, Nucleic Acids Res., 40, 2995, 10.1093\u002Fnar\u002Fgkr1153",{"doi":8527},"10.1093\u002Fnar\u002Fgkr1153",{"id":21,"text":8529,"url":21,"identifiers":8530},"Vu, 2014, Chromatin features of plant telomeric sequences at terminal vs. internal positions, Front. Plant Sci., 5, 593",{},{"id":21,"text":8532,"url":21,"identifiers":8533},"Huang, 2014, Telomere regulation in pluripotent stem cells, Protein Cell, 5, 194, 10.1007\u002Fs13238-014-0028-1",{"doi":8534},"10.1007\u002Fs13238-014-0028-1",{"id":21,"text":8536,"url":21,"identifiers":8537},"Liu, 2017, Linking telomere regulation to stem cell pluripotency, Trends Genet., 33, 16, 10.1016\u002Fj.tig.2016.10.007",{"doi":8538},"10.1016\u002Fj.tig.2016.10.007",{"id":21,"text":8540,"url":21,"identifiers":8541},"Bodnar, 1998, Extension of life-span by introduction of telomerase into normal human cells, Science, 279, 349, 10.1126\u002Fscience.279.5349.349",{"doi":8542},"10.1126\u002Fscience.279.5349.349",{"id":21,"text":8544,"url":21,"identifiers":8545},"Grossi, 2004, Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation, Genes Dev., 18, 992, 10.1101\u002Fgad.300004",{"doi":8546},"10.1101\u002Fgad.300004",{"id":21,"text":8548,"url":21,"identifiers":8549},"Qi, 2000, The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein, Genes Dev., 14, 1777, 10.1101\u002Fgad.14.14.1777",{"doi":8550},"10.1101\u002Fgad.14.14.1777",{"id":21,"text":8552,"url":21,"identifiers":8553},"Diede, 1999, Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta, Cell, 99, 723, 10.1016\u002FS0092-8674(00)81670-0",{"doi":8554},"10.1016\u002FS0092-8674(00)81670-0",{"id":21,"text":8556,"url":21,"identifiers":8557},"Carson, 1985, CDC17: An essential gene that prevents telomere elongation in yeast, Cell, 42, 249, 10.1016\u002FS0092-8674(85)80120-3",{"doi":8558},"10.1016\u002FS0092-8674(85)80120-3",{"id":21,"text":8560,"url":21,"identifiers":8561},"Adams, 1996, Specific DNA replication mutations affect telomere length in Saccharomyces cerevisiae, Mol. Cell. Biol., 16, 4614, 10.1128\u002FMCB.16.9.4614",{"doi":8562},"10.1128\u002FMCB.16.9.4614",{"id":21,"text":8564,"url":21,"identifiers":8565},"Dionne, 2000, The function of DNA polymerase alpha at telomeric G tails is important for telomere homeostasis, Mol. Cell. Biol., 20, 786, 10.1128\u002FMCB.20.3.786-796.2000",{"doi":8566},"10.1128\u002FMCB.20.3.786-796.2000",{"id":21,"text":8568,"url":21,"identifiers":8569},"Parenteau, 2002, Differential processing of leading- and lagging-strand ends at Saccharomyces cerevisiae telomeres revealed by the absence of Rad27p nuclease, Genetics, 162, 1583, 10.1093\u002Fgenetics\u002F162.4.1583",{"doi":8570},"10.1093\u002Fgenetics\u002F162.4.1583",{"id":21,"text":8572,"url":21,"identifiers":8573},"Casteel, 2009, A DNA polymerase alpha- primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells, J. Biol. Chem., 284, 5807, 10.1074\u002Fjbc.M807593200",{"doi":8574},"10.1074\u002Fjbc.M807593200",{"id":21,"text":8576,"url":21,"identifiers":8577},"Wang, 2012, Human CST has independent functions during telomere duplex replication and C-strand fill-in, Cell Rep., 2, 1096, 10.1016\u002Fj.celrep.2012.10.007",{"doi":8578},"10.1016\u002Fj.celrep.2012.10.007",{"id":21,"text":8580,"url":21,"identifiers":8581},"Chen, 2012, The human CST complex is a terminator of telomerase activity, Nature, 488, 540, 10.1038\u002Fnature11269",{"doi":8582},"10.1038\u002Fnature11269",{"id":21,"text":8584,"url":21,"identifiers":8585},"Price, 2010, Evolution of CST function in telomere maintenance, Cell Cycle, 9, 3157, 10.4161\u002Fcc.9.16.12547",{"doi":8586},"10.4161\u002Fcc.9.16.12547",{"id":21,"text":8588,"url":21,"identifiers":8589},"Stewart, 2012, Human CST promotes telomere duplex replication and general replication restart after fork stalling, EMBO J., 31, 3537, 10.1038\u002Femboj.2012.215",{"doi":8590},"10.1038\u002Femboj.2012.215",{"id":21,"text":8592,"url":21,"identifiers":8593},"Wu, 2012, Telomeric 3′ overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST, Cell, 150, 39, 10.1016\u002Fj.cell.2012.05.026",{"doi":8594},"10.1016\u002Fj.cell.2012.05.026",{"id":21,"text":8596,"url":21,"identifiers":8597},"Chen, 2013, CST for the grand finale of telomere replication, Nucleus, 4, 277, 10.4161\u002Fnucl.25701",{"doi":8598},"10.4161\u002Fnucl.25701",{"id":21,"text":8600,"url":21,"identifiers":8601},"Goulian, 1990, The mechanism of action of an accessory protein for DNA polymerase alpha\u002Fprimase, J. Biol. Chem., 265, 13231, 10.1016\u002FS0021-9258(19)38289-4",{"doi":8602},"10.1016\u002FS0021-9258(19)38289-4",{"id":21,"text":8604,"url":21,"identifiers":8605},"Goulian, 1990, Purification and properties of an accessory protein for DNA polymerase alpha\u002Fprimase, J. Biol. Chem., 265, 13221, 10.1016\u002FS0021-9258(19)38288-2",{"doi":8606},"10.1016\u002FS0021-9258(19)38288-2",{"id":21,"text":8608,"url":21,"identifiers":8609},"Chandra, 2001, Cdc13 both positively and negatively regulates telomere replication, Genes Dev., 15, 404, 10.1101\u002Fgad.861001",{"doi":8610},"10.1101\u002Fgad.861001",{"id":21,"text":8612,"url":21,"identifiers":8613},"Pennock, 2001, Cdc13 delivers separate complexes to the telomere for end protection and replication, Cell, 104, 387, 10.1016\u002FS0092-8674(01)00226-4",{"doi":8614},"10.1016\u002FS0092-8674(01)00226-4",{"id":21,"text":8616,"url":21,"identifiers":8617},"Gopalakrishnan, 2017, Sequential phosphorylation of CST subunits by different cyclin-Cdk1 complexes orchestrate telomere replication, Cell Cycle, 16, 1271, 10.1080\u002F15384101.2017.1312235",{"doi":8618},"10.1080\u002F15384101.2017.1312235",{"id":21,"text":8620,"url":21,"identifiers":8621},"Tseng, 2006, The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p\u002FTel1p-dependent phosphorylation, Nucleic Acids Res., 34, 6327, 10.1093\u002Fnar\u002Fgkl786",{"doi":8622},"10.1093\u002Fnar\u002Fgkl786",{"id":21,"text":8624,"url":21,"identifiers":8625},"Shen, 2014, PP2A and Aurora differentially modify Cdc13 to promote telomerase release from telomeres at G2\u002FM phase, Nat. Commun., 5, 5312, 10.1038\u002Fncomms6312",{"doi":8626},"10.1038\u002Fncomms6312",{"id":21,"text":8628,"url":21,"identifiers":8629},"Hang, 2011, SUMOylation regulates telomere length homeostasis by targeting Cdc13, Nat. Struct. Mol. Biol., 18, 920, 10.1038\u002Fnsmb.2100",{"doi":8630},"10.1038\u002Fnsmb.2100",{"id":21,"text":8632,"url":21,"identifiers":8633},"Greider, 2016, Regulating telomere length from the inside out: The replication fork model, Genes Dev., 30, 1483, 10.1101\u002Fgad.280578.116",{"doi":8634},"10.1101\u002Fgad.280578.116",{"id":21,"text":8636,"url":21,"identifiers":8637},"Marcand, 1997, A protein-counting mechanism for telomere length regulation in yeast, Science, 275, 986, 10.1126\u002Fscience.275.5302.986",{"doi":8638},"10.1126\u002Fscience.275.5302.986",{"id":21,"text":8640,"url":21,"identifiers":8641},"Lundblad, 2002, Telomere maintenance without telomerase, Oncogene, 21, 522, 10.1038\u002Fsj.onc.1205079",{"doi":8642},"10.1038\u002Fsj.onc.1205079",{"id":21,"text":8644,"url":21,"identifiers":8645},"Cesare, 2010, Alternative lengthening of telomeres: Models, mechanisms and implications, Nat. Rev. Genet., 11, 319, 10.1038\u002Fnrg2763",{"doi":8646},"10.1038\u002Fnrg2763",{"id":21,"text":8648,"url":21,"identifiers":8649},"Bryan, 1995, Telomere elongation in immortal human cells without detectable telomerase activity, EMBO J., 14, 4240, 10.1002\u002Fj.1460-2075.1995.tb00098.x",{"doi":8650},"10.1002\u002Fj.1460-2075.1995.tb00098.x",{"id":21,"text":8652,"url":21,"identifiers":8653},"Bryan, 1997, Telomere dynamics and telomerase activity in in vitro immortalised human cells, Eur. J. Cancer, 33, 767, 10.1016\u002FS0959-8049(97)00065-8",{"doi":8654},"10.1016\u002FS0959-8049(97)00065-8",{"id":21,"text":8656,"url":21,"identifiers":8657},"Cerone, 2001, Telomere maintenance by telomerase and by recombination can coexist in human cells, Hum. Mol. Genet., 10, 1945, 10.1093\u002Fhmg\u002F10.18.1945",{"doi":8658},"10.1093\u002Fhmg\u002F10.18.1945",{"id":21,"text":8660,"url":21,"identifiers":8661},"Samassekou, 2013, Presence of alternative lengthening of telomeres associated circular extrachromosome telomere repeats in primary leukemia cells of chronic myeloid leukemia, J. Hematol. Oncol., 6, 26, 10.1186\u002F1756-8722-6-26",{"doi":8662},"10.1186\u002F1756-8722-6-26",{"id":21,"text":8664,"url":21,"identifiers":8665},"Slatter, 2012, The alternative lengthening of telomeres pathway may operate in non-neoplastic human cells, J. Pathol., 226, 509, 10.1002\u002Fpath.2981",{"doi":8666},"10.1002\u002Fpath.2981",{"id":21,"text":8668,"url":21,"identifiers":8669},"Neumann, 2013, Alternative lengthening of telomeres in normal mammalian somatic cells, Genes Dev., 27, 18, 10.1101\u002Fgad.205062.112",{"doi":8670},"10.1101\u002Fgad.205062.112",{"id":21,"text":8672,"url":21,"identifiers":8673},"Liu, 2007, Telomere lengthening early in development, Nat. Cell Biol., 9, 1436, 10.1038\u002Fncb1664",{"doi":8674},"10.1038\u002Fncb1664",{"id":21,"text":8676,"url":21,"identifiers":8677},"Friml, 2008, Role of alternative telomere lengthening unmasked in telomerase knock-out mutant plants, Plant Mol. Biol., 66, 637, 10.1007\u002Fs11103-008-9295-7",{"doi":8678},"10.1007\u002Fs11103-008-9295-7",{"id":21,"text":8680,"url":21,"identifiers":8681},"Yu, 1990, In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs, Nature, 344, 126, 10.1038\u002F344126a0",{"doi":8682},"10.1038\u002F344126a0",{"id":21,"text":8684,"url":21,"identifiers":8685},"Singer, 1994, TLC1: Template RNA component of Saccharomyces cerevisiae telomerase, Science, 266, 404, 10.1126\u002Fscience.7545955",{"doi":8686},"10.1126\u002Fscience.7545955",{"id":21,"text":8688,"url":21,"identifiers":8689},"McEachern, 1996, Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase, Genes Dev., 10, 1822, 10.1101\u002Fgad.10.14.1822",{"doi":8690},"10.1101\u002Fgad.10.14.1822",{"id":21,"text":8692,"url":21,"identifiers":8693},"Teng, 1999, Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae, Mol. Cell. Biol., 19, 8083, 10.1128\u002FMCB.19.12.8083",{"doi":8694},"10.1128\u002FMCB.19.12.8083",{"id":21,"text":8696,"url":21,"identifiers":8697},"Le, 1999, RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase, Genetics, 152, 143, 10.1093\u002Fgenetics\u002F152.1.143",{"doi":8698},"10.1093\u002Fgenetics\u002F152.1.143",{"id":21,"text":8700,"url":21,"identifiers":8701},"Chen, 2001, Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events, Mol. Cell. Biol., 21, 1819, 10.1128\u002FMCB.21.5.1819-1827.2001",{"doi":8702},"10.1128\u002FMCB.21.5.1819-1827.2001",{"id":21,"text":8704,"url":21,"identifiers":8705},"Huang, 2001, SGS1 is required for telomere elongation in the absence of telomerase, Curr. Biol., 11, 125, 10.1016\u002FS0960-9822(01)00021-5",{"doi":8706},"10.1016\u002FS0960-9822(01)00021-5",{"id":21,"text":8708,"url":21,"identifiers":8709},"Cohen, 2001, Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase, Proc. Natl. Acad. Sci. USA, 98, 3174, 10.1073\u002Fpnas.061579598",{"doi":8710},"10.1073\u002Fpnas.061579598",{"id":21,"text":8712,"url":21,"identifiers":8713},"Lydeard, 2007, Break-induced replication and telomerase-independent telomere maintenance require Pol32, Nature, 448, 820, 10.1038\u002Fnature06047",{"doi":8714},"10.1038\u002Fnature06047",{"id":21,"text":8716,"url":21,"identifiers":8717},"Teng, 2000, Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process, Mol. Cell, 6, 947, 10.1016\u002FS1097-2765(05)00094-8",{"doi":8718},"10.1016\u002FS1097-2765(05)00094-8",{"id":21,"text":8720,"url":21,"identifiers":8721},"Johnson, 2001, The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase, EMBO J., 20, 905, 10.1093\u002Femboj\u002F20.4.905",{"doi":8722},"10.1093\u002Femboj\u002F20.4.905",{"id":21,"text":8724,"url":21,"identifiers":8725},"Tsai, 2002, Involvement of replicative polymerases, Tel1p, Mec1p, Cdc13p, and the Ku complex in telomere-telomere recombination, Mol. Cell. Biol., 22, 5679, 10.1128\u002FMCB.22.16.5679-5687.2002",{"doi":8726},"10.1128\u002FMCB.22.16.5679-5687.2002",{"id":21,"text":8728,"url":21,"identifiers":8729},"Maringele, 2004, Telomerase- and recombination-independent immortalization of budding yeast, Genes Dev., 18, 2663, 10.1101\u002Fgad.316504",{"doi":8730},"10.1101\u002Fgad.316504",{"id":21,"text":8732,"url":21,"identifiers":8733},"Lee, 2008, Sgs1 RecQ helicase inhibits survival of Saccharomyces cerevisiae cells lacking telomerase and homologous recombination, J. Biol. Chem., 283, 29847, 10.1074\u002Fjbc.M804760200",{"doi":8734},"10.1074\u002Fjbc.M804760200",{"id":21,"text":8736,"url":21,"identifiers":8737},"Grandin, 2001, Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13, EMBO J., 20, 1173, 10.1093\u002Femboj\u002F20.5.1173",{"doi":8738},"10.1093\u002Femboj\u002F20.5.1173",{"id":21,"text":8740,"url":21,"identifiers":8741},"Murnane, 1994, Telomere dynamics in an immortal human cell line, EMBO J., 13, 4953, 10.1002\u002Fj.1460-2075.1994.tb06822.x",{"doi":8742},"10.1002\u002Fj.1460-2075.1994.tb06822.x",{"id":21,"text":8744,"url":21,"identifiers":8745},"Cazes, 2004, Alternative lengthening of telomeres is characterized by high rates of telomeric exchange, Cancer Res., 64, 2324, 10.1158\u002F0008-5472.CAN-03-4035",{"doi":8746},"10.1158\u002F0008-5472.CAN-03-4035",{"id":21,"text":8748,"url":21,"identifiers":8749},"Cesare, 2004, Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops, Mol. Cell. Biol., 24, 9948, 10.1128\u002FMCB.24.22.9948-9957.2004",{"doi":8750},"10.1128\u002FMCB.24.22.9948-9957.2004",{"id":21,"text":8752,"url":21,"identifiers":8753},"Nabetani, 2009, Unusual telomeric DNAs in human telomerase-negative immortalized cells, Mol. Cell. Biol., 29, 703, 10.1128\u002FMCB.00603-08",{"doi":8754},"10.1128\u002FMCB.00603-08",{"id":21,"text":8756,"url":21,"identifiers":8757},"Yeager, 1999, Telomerase-negative immortalized human cells contain a novel type of Promyelocytic Leukemia (PML) body, Cancer Res., 59, 4175",{},{"id":21,"text":8759,"url":21,"identifiers":8760},"Dilley, 2016, Break-induced telomere synthesis underlies alternative telomere maintenance, Nature, 539, 54, 10.1038\u002Fnature20099",{"doi":8761},"10.1038\u002Fnature20099",{"id":21,"text":8763,"url":21,"identifiers":8764},"Roumelioti, 2016, Alternative lengthening of human telomeres is a conservative DNA replication process with features of break-induced replication, EMBO Rep., 17, 1731, 10.15252\u002Fembr.201643169",{"doi":8765},"10.15252\u002Fembr.201643169",{"id":21,"text":8767,"url":21,"identifiers":8768},"Min, J., Wright, W.E., and Shay, J.W. (2017). Alternative lengthening of telomeres mediated by mitotic DNA synthesis engages break-induced replication processes. Mol. Cell. Biol.",{"doi":8769},"10.1128\u002FMCB.00226-17",{"id":21,"text":8771,"url":21,"identifiers":8772},"Sobinoff, 2017, BLM and SLX4 play opposing roles in recombination-dependent replication at human telomeres, EMBO J., 36, 2907, 10.15252\u002Fembj.201796889",{"doi":8773},"10.15252\u002Fembj.201796889",{"id":21,"text":8775,"url":21,"identifiers":8776},"Bournique, 2016, Proteomic profiling reveals a specific role for translesion DNA polymerase η in the alternative lengthening of telomeres, Cell Rep., 17, 1858, 10.1016\u002Fj.celrep.2016.10.048",{"doi":8777},"10.1016\u002Fj.celrep.2016.10.048",{"id":21,"text":8779,"url":21,"identifiers":8780},"Sobinoff, 2017, Alternative lengthening of telomeres: DNA repair pathways converge, Trends Genet., 33, 921, 10.1016\u002Fj.tig.2017.09.003",{"doi":8781},"10.1016\u002Fj.tig.2017.09.003",{"id":21,"text":8783,"url":21,"identifiers":8784},"Heaphy, 2011, Altered telomeres in tumors with ATRX and DAXX mutations, Science, 333, 425, 10.1126\u002Fscience.1207313",{"doi":8785},"10.1126\u002Fscience.1207313",{"id":21,"text":8787,"url":21,"identifiers":8788},"Lovejoy, C.A., Li, W., Reisenweber, S., Thongthip, S., Bruno, J., de Lange, T., De, S., Petrini, J.H.J., Sung, P.A., and Jasin, M. (2012). Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. PLoS Genet., 8.",{"doi":8789},"10.1371\u002Fjournal.pgen.1002772",{"id":21,"text":8791,"url":21,"identifiers":8792},"Schwartzentruber, 2012, Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma, Nature, 482, 226, 10.1038\u002Fnature10833",{"doi":8793},"10.1038\u002Fnature10833",{"id":21,"text":8795,"url":21,"identifiers":8796},"Haase, 2018, Mutant ATRX: Uncovering a new therapeutic target for glioma, Expert Opin. Ther. Targets, 22, 599, 10.1080\u002F14728222.2018.1487953",{"doi":8797},"10.1080\u002F14728222.2018.1487953",{"id":21,"text":8799,"url":21,"identifiers":8800},"Arnoult, 2014, Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1, Nat. Struct. Mol. Biol., 21, 167, 10.1038\u002Fnsmb.2754",{"doi":8801},"10.1038\u002Fnsmb.2754",{"id":21,"text":8803,"url":21,"identifiers":8804},"Episkopou, 2014, Alternative lengthening of telomeres is characterized by reduced compaction of telomeric chromatin, Nucleic Acids Res., 42, 4391, 10.1093\u002Fnar\u002Fgku114",{"doi":8805},"10.1093\u002Fnar\u002Fgku114",{"id":21,"text":8807,"url":21,"identifiers":8808},"Kingston, 2009, Purification of proteins associated with specific genomic loci, Cell, 136, 175, 10.1016\u002Fj.cell.2008.11.045",{"doi":8809},"10.1016\u002Fj.cell.2008.11.045",{"id":21,"text":8811,"url":21,"identifiers":8812},"Conomos, 2012, Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells, J. Cell Biol., 199, 893, 10.1083\u002Fjcb.201207189",{"doi":8813},"10.1083\u002Fjcb.201207189",{"id":21,"text":8815,"url":21,"identifiers":8816},"Marzec, 2015, Nuclear-receptor-mediated telomere insertion leads to genome instability in ALT cancers, Cell, 160, 913, 10.1016\u002Fj.cell.2015.01.044",{"doi":8817},"10.1016\u002Fj.cell.2015.01.044",{"id":21,"text":8819,"url":21,"identifiers":8820},"Conomos, 2014, NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination, Nat. Struct. Mol. Biol., 21, 760, 10.1038\u002Fnsmb.2877",{"doi":8821},"10.1038\u002Fnsmb.2877",{"id":21,"text":8823,"url":21,"identifiers":8824},"Iglesias, 2011, Subtelomeric repetitive elements determine TERRA regulation by Rap1\u002FRif and Rap1\u002FSir complexes in yeast, EMBO Rep., 12, 587, 10.1038\u002Fembor.2011.73",{"doi":8825},"10.1038\u002Fembor.2011.73",{"id":21,"text":8827,"url":21,"identifiers":8828},"Yu, 2014, Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase, Proc. Natl. Acad. Sci. USA, 111, 3377, 10.1073\u002Fpnas.1307415111",{"doi":8829},"10.1073\u002Fpnas.1307415111",{"id":21,"text":8831,"url":21,"identifiers":8832},"Wells, 1990, Telomere-related sequences at interstitial sites in the human genome, Genomics, 8, 699, 10.1016\u002F0888-7543(90)90257-U",{"doi":8833},"10.1016\u002F0888-7543(90)90257-U",{"id":21,"text":8835,"url":21,"identifiers":8836},"Azzalin, 2002, Distribution of intrachromosomal telomeric sequences (ITS) on Macaca fascicularis (Primates) chromosomes and their implication for chromosome evolution, Hum. Genet., 110, 578, 10.1007\u002Fs00439-002-0730-6",{"doi":8837},"10.1007\u002Fs00439-002-0730-6",{"id":21,"text":8839,"url":21,"identifiers":8840},"Giulotto, 2005, Evolutionary breakpoints are co-localized with fragile sites and intrachromosomal telomeric sequences in primates, Cytogenet. Genome Res., 108, 234, 10.1159\u002F000080822",{"doi":8841},"10.1159\u002F000080822",{"id":21,"text":8843,"url":21,"identifiers":8844},"Nergadze, 2008, Telomeric repeats far from the ends: Mechanisms of origin and role in evolution, Cytogenet. Genome Res., 122, 219, 10.1159\u002F000167807",{"doi":8845},"10.1159\u002F000167807",{"id":21,"text":8847,"url":21,"identifiers":8848},"He, 2013, Interstitial telomeric repeats are enriched in the centromeres of chromosomes in Solanum species, Chromosom. Res., 21, 5, 10.1007\u002Fs10577-012-9332-x",{"doi":8849},"10.1007\u002Fs10577-012-9332-x",{"id":21,"text":8851,"url":21,"identifiers":8852},"2017, Interstitial telomeric sequences in vertebrate chromosomes: Origin, function, instability and evolution, Mutat. Res. Mutat. Res., 773, 51, 10.1016\u002Fj.mrrev.2017.04.002",{"doi":8853},"10.1016\u002Fj.mrrev.2017.04.002",{"id":21,"text":8855,"url":21,"identifiers":8856},"Weber, 1990, Characterization and organization of DNA sequences adjacent to the human telomere associated repeat (TTAGGG)n, Nucleic Acids Res., 18, 3353, 10.1093\u002Fnar\u002F18.11.3353",{"doi":8857},"10.1093\u002Fnar\u002F18.11.3353",{"id":21,"text":8859,"url":21,"identifiers":8860},"Meyne, 1990, Distribution of non-telomeric sites of the (TTAGGG)n telomeric sequence in vertebrate chromosomes, Chromosoma, 99, 3, 10.1007\u002FBF01737283",{"doi":8861},"10.1007\u002FBF01737283",{"id":21,"text":8863,"url":21,"identifiers":8864},"Weber, 1991, Intrachromosomal location of the telomeric repeat (TTAGGG)n, Mamm. Genome, 1, 211, 10.1007\u002FBF00352327",{"doi":8865},"10.1007\u002FBF00352327",{"id":21,"text":8867,"url":21,"identifiers":8868},"Cox, 1993, Comparison of plant telomere locations using a PCR-generated synthetic probe, Ann. Bot., 72, 239, 10.1006\u002Fanbo.1993.1104",{"doi":8869},"10.1006\u002Fanbo.1993.1104",{"id":21,"text":8871,"url":21,"identifiers":8872},"Azzalin, 1997, Fluorescence in situ hybridization with a synthetic (T2AG3)n polynucleotide detects several intrachromosomal telomere-like repeats on human chromosomes, Cytogenet. Cell Genet., 78, 112, 10.1159\u002F000134640",{"doi":8873},"10.1159\u002F000134640",{"id":21,"text":8875,"url":21,"identifiers":8876},"Mondello, 2000, Instability of interstitial telomeric sequences in the human genome, Genomics, 68, 111, 10.1006\u002Fgeno.2000.6280",{"doi":8877},"10.1006\u002Fgeno.2000.6280",{"id":21,"text":8879,"url":21,"identifiers":8880},"Azzalin, 2001, Human intrachromosomal telomeric-like repeats: Sequence organization and mechanisms of origin, Chromosoma, 110, 75, 10.1007\u002Fs004120100135",{"doi":8881},"10.1007\u002Fs004120100135",{"id":21,"text":8883,"url":21,"identifiers":8884},"Uchida, 2002, Interstitial telomere-like repeats in the Arabidopsis thaliana genome, Genes Genet. Syst., 77, 63, 10.1266\u002Fggs.77.63",{"doi":8885},"10.1266\u002Fggs.77.63",{"id":21,"text":8887,"url":21,"identifiers":8888},"Flint, 1997, Sequence comparison of human and yeast telomeres identifies structurally distinct subtelomeric domains, Hum. Mol. Genet., 6, 1305, 10.1093\u002Fhmg\u002F6.8.1305",{"doi":8889},"10.1093\u002Fhmg\u002F6.8.1305",{"id":21,"text":8891,"url":21,"identifiers":8892},"Ambrosini, 2007, Human subtelomeric duplicon structure and organization, Genome Biol., 8, R151, 10.1186\u002Fgb-2007-8-7-r151",{"doi":8893},"10.1186\u002Fgb-2007-8-7-r151",{"id":21,"text":8895,"url":21,"identifiers":8896},"IJdo, 1991, Origin of human chromosome 2: An ancestral telomere-telomere fusion, Proc. Natl. Acad. Sci. USA, 88, 9051, 10.1073\u002Fpnas.88.20.9051",{"doi":8897},"10.1073\u002Fpnas.88.20.9051",{"id":21,"text":8899,"url":21,"identifiers":8900},"Fan, 2002, Genomic structure and evolution of the ancestral chromosome fusion site in 2q13-2q14.1 and paralogous regions on other human chromosomes, Genome Res., 12, 1651, 10.1101\u002Fgr.337602",{"doi":8901},"10.1101\u002Fgr.337602",{"id":21,"text":8903,"url":21,"identifiers":8904},"Slijepcevic, 1998, Telomeres and mechanisms of Robertsonian fusion, Chromosoma, 107, 136, 10.1007\u002Fs004120050289",{"doi":8905},"10.1007\u002Fs004120050289",{"id":21,"text":8907,"url":21,"identifiers":8908},"Capilla, 2015, On the origin of Robertsonian fusions in nature: Evidence of telomere shortening in wild house mice, J. Evol. Biol., 28, 241, 10.1111\u002Fjeb.12568",{"doi":8909},"10.1111\u002Fjeb.12568",{"id":21,"text":8911,"url":21,"identifiers":8912},"Rovatsos, 2011, Rapid, independent, and extensive amplification of telomeric repeats in pericentromeric regions in karyotypes of arvicoline rodents, Chromosom. Res., 19, 869, 10.1007\u002Fs10577-011-9242-3",{"doi":8913},"10.1007\u002Fs10577-011-9242-3",{"id":21,"text":8915,"url":21,"identifiers":8916},"Rovatsos, M., Kratochvíl, L., Altmanová, M., and Johnson Pokorná, M. (2015). Interstitial telomeric motifs in squamate reptiles: When the exceptions outnumber the rule. PLoS ONE, 10.",{"doi":8917},"10.1371\u002Fjournal.pone.0134985",{"id":21,"text":8919,"url":21,"identifiers":8920},"Nergadze, 2007, Contribution of telomerase RNA retrotranscription to DNA double-strand break repair during mammalian genome evolution, Genome Biol., 8, R260, 10.1186\u002Fgb-2007-8-12-r260",{"doi":8921},"10.1186\u002Fgb-2007-8-12-r260",{"id":21,"text":8923,"url":21,"identifiers":8924},"Lin, 2008, Endings in the middle: Current knowledge of interstitial telomeric sequences, Mutat. Res., 658, 95, 10.1016\u002Fj.mrrev.2007.08.006",{"doi":8925},"10.1016\u002Fj.mrrev.2007.08.006",{"id":21,"text":8927,"url":21,"identifiers":8928},"Nergadze, 2004, Insertion of telomeric repeats at intrachromosomal break sites during primate evolution, Genome Res., 14, 1704, 10.1101\u002Fgr.2778904",{"doi":8929},"10.1101\u002Fgr.2778904",{"id":21,"text":8931,"url":21,"identifiers":8932},"Simonet, 2011, The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats, Cell Res., 21, 1028, 10.1038\u002Fcr.2011.40",{"doi":8933},"10.1038\u002Fcr.2011.40",{"id":21,"text":8935,"url":21,"identifiers":8936},"Wood, 2014, TRF2 and lamin A\u002FC interact to facilitate the functional organization of chromosome ends, Nat. Commun., 5, 5467, 10.1038\u002Fncomms6467",{"doi":8937},"10.1038\u002Fncomms6467",{"id":21,"text":8939,"url":21,"identifiers":8940},"Jia, 2017, Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells, Nucleic Acids Res., 45, 1219, 10.1093\u002Fnar\u002Fgkw1170",{"doi":8941},"10.1093\u002Fnar\u002Fgkw1170",{"id":21,"text":8943,"url":21,"identifiers":8944},"Jia, 2018, The MLH1 ATPase domain is needed for suppressing aberrant formation of interstitial telomeric sequences, DNA Repair, 65, 20, 10.1016\u002Fj.dnarep.2018.03.002",{"doi":8945},"10.1016\u002Fj.dnarep.2018.03.002",{"id":21,"text":8947,"url":21,"identifiers":8948},"Lim, 2003, Telomere variability in the monocotyledonous plant order Asparagales, Proc. Biol. Sci., 270, 1893, 10.1098\u002Frspb.2003.2446",{"doi":8949},"10.1098\u002Frspb.2003.2446",{"id":21,"text":8951,"url":21,"identifiers":8952},"Souza, 2016, Interstitial telomeric sites and Robertsonian translocations in species of Ipheion and Nothoscordum (Amaryllidaceae), Genetica, 144, 157, 10.1007\u002Fs10709-016-9886-1",{"doi":8953},"10.1007\u002Fs10709-016-9886-1",{"id":21,"text":8955,"url":21,"identifiers":8956},"Lim, 2003, The signature of the Cestrum genome suggests an evolutionary response to the loss of (TTTAGGG)n telomeres, Chromosoma, 112, 164, 10.1007\u002Fs00412-003-0256-2",{"doi":8957},"10.1007\u002Fs00412-003-0256-2",{"id":21,"text":8959,"url":21,"identifiers":8960},"Fajkus, 2015, Characterisation of an unusual telomere motif (TTTTTTAGGG)n in the plant Cestrum elegans (Solanaceae), a species with a large genome, Plant J., 82, 644, 10.1111\u002Ftpj.12839",{"doi":8961},"10.1111\u002Ftpj.12839",{"id":21,"text":8963,"url":21,"identifiers":8964},"Dumas, 2016, Chromosomal distribution of interstitial telomeric sequences in nine neotropical primates (Platyrrhini): Possible implications in evolution and phylogeny, J. Zool. Syst. Evol. Res., 54, 226, 10.1111\u002Fjzs.12131",{"doi":8965},"10.1111\u002Fjzs.12131",{"id":21,"text":8967,"url":21,"identifiers":8968},"Mazzoleni, 2017, Distribution of interstitial telomeric sequences in Primates and the Pygmy tree shrew (Scandentia), Cytogenet. Genome Res., 151, 141, 10.1159\u002F000467634",{"doi":8969},"10.1159\u002F000467634",{"id":21,"text":8971,"url":21,"identifiers":8972},"Alvarez, 1993, Chromosomal radiosensitivity at intrachromosomal telomeric sites, Genes. Chromosomes Cancer, 8, 8, 10.1002\u002Fgcc.2870080103",{"doi":8973},"10.1002\u002Fgcc.2870080103",{"id":21,"text":8975,"url":21,"identifiers":8976},"Bertoni, 1996, Intrachromosomal telomere-like DNA sequences in Chinese hamster, Mamm. Genome, 7, 853, 10.1007\u002Fs003359900250",{"doi":8977},"10.1007\u002Fs003359900250",{"id":21,"text":8979,"url":21,"identifiers":8980},"Musio, 1996, Spontaneous and aphidicolin-sensitive fragile site 3cen co-localizes with the (TTAGGG)n telomeric sequence in Chinese hamster cells, Cytogenet. Genome Res., 75, 159, 10.1159\u002F000134469",{"doi":8981},"10.1159\u002F000134469",{"id":21,"text":8983,"url":21,"identifiers":8984},"Slijepcevic, 1996, Spontaneous and radiation-induced chromosomal breakage at interstitial telomeric sites, Chromosoma, 104, 596, 10.1007\u002FBF00352299",{"doi":8985},"10.1007\u002FBF00352299",{"id":21,"text":8987,"url":21,"identifiers":8988},"Camats, 2006, Genomic instability in rat: Breakpoints induced by ionising radiation and interstitial telomeric-like sequences, Mutat. Res., 595, 156, 10.1016\u002Fj.mrfmmm.2005.11.002",{"doi":8989},"10.1016\u002Fj.mrfmmm.2005.11.002",{"id":21,"text":8991,"url":21,"identifiers":8992},"Schneider, 2013, Chromosomal evolution of neotropical cichlids: The role of repetitive DNA sequences in the organization and structure of karyotype, Rev. Fish Biol. Fish., 23, 201, 10.1007\u002Fs11160-012-9285-3",{"doi":8993},"10.1007\u002Fs11160-012-9285-3",{"id":21,"text":8995,"url":21,"identifiers":8996},"Barros, 2017, Fragile sites, dysfunctional telomere and chromosome fusions: What is 5S rDNA role?, Gene, 608, 20, 10.1016\u002Fj.gene.2017.01.013",{"doi":8997},"10.1016\u002Fj.gene.2017.01.013",{"id":21,"text":8999,"url":21,"identifiers":9000},"Glugoski, 2018, Co-located hAT transposable element and 5S rDNA in an interstitial telomeric sequence suggest the formation of Robertsonian fusion in armored catfish, Gene, 650, 49, 10.1016\u002Fj.gene.2018.01.099",{"doi":9001},"10.1016\u002Fj.gene.2018.01.099",{"id":21,"text":9003,"url":21,"identifiers":9004},"Rosato, 2018, Inter- and intraspecific hypervariability in interstitial telomeric-like repeats (TTTAGGG)n in Anacyclus (Asteraceae), Ann. Bot., 122, 387, 10.1093\u002Faob\u002Fmcy079",{"doi":9005},"10.1093\u002Faob\u002Fmcy079",{"id":21,"text":9007,"url":21,"identifiers":9008},"Bosco, 2012, A TRF1-controlled common fragile site containing interstitial telomeric sequences, Chromosoma, 121, 465, 10.1007\u002Fs00412-012-0377-6",{"doi":9009},"10.1007\u002Fs00412-012-0377-6",{"id":21,"text":9011,"url":21,"identifiers":9012},"Bianchi, 2006, Telomeres, interstitial telomeric repeat sequences, and chromosomal aberrations, Mutat. Res., 612, 189, 10.1016\u002Fj.mrrev.2005.12.003",{"doi":9013},"10.1016\u002Fj.mrrev.2005.12.003",{"id":21,"text":9015,"url":21,"identifiers":9016},"Bianchi, 2010, Relationship between heterochromatic interstitial telomeric sequences and chromosome damage induced by the radiomimetic compound streptonigrin in Chinese hamster ovary cells, Mutat. Res., 684, 90, 10.1016\u002Fj.mrfmmm.2009.12.005",{"doi":9017},"10.1016\u002Fj.mrfmmm.2009.12.005",{"id":21,"text":9019,"url":21,"identifiers":9020},"2012, Chromosomal aberrations involving telomeres and interstitial telomeric sequences, Mutagenesis, 27, 1, 10.1093\u002Fmutage\u002Fger052",{"doi":9021},"10.1093\u002Fmutage\u002Fger052",{"id":21,"text":9023,"url":21,"identifiers":9024},"Swier, 2012, Do Time, heterochromatin, NORs, or chromosomal rearrangements correlate with distribution of interstitial telomeric repeats in Sigmodon (cotton rats)?, J. Hered., 103, 493, 10.1093\u002Fjhered\u002Fess029",{"doi":9025},"10.1093\u002Fjhered\u002Fess029",{"id":21,"text":9027,"url":21,"identifiers":9028},"Hastie, 1989, Human telomeres: Fusion and interstitial sites, Trends Genet., 5, 326, 10.1016\u002F0168-9525(89)90137-6",{"doi":9029},"10.1016\u002F0168-9525(89)90137-6",{"id":21,"text":9031,"url":21,"identifiers":9032},"Yen, 1996, A polymorphic interstitial telomere array near the center of mouse chromosome 8, Mamm. Genome, 7, 218, 10.1007\u002Fs003359900059",{"doi":9033},"10.1007\u002Fs003359900059",{"id":21,"text":9035,"url":21,"identifiers":9036},"Samassekou, 2011, Polymorphism in a human chromosome-specific interstitial telomere-like sequence at 22q11.2, Cytogenet. Genome Res., 134, 174, 10.1159\u002F000328862",{"doi":9037},"10.1159\u002F000328862",{"id":21,"text":9039,"url":21,"identifiers":9040},"Pluta, 1989, Recombination occurs during telomere formation in yeast, Nature, 337, 429, 10.1038\u002F337429a0",{"doi":9041},"10.1038\u002F337429a0",{"id":21,"text":9043,"url":21,"identifiers":9044},"Ashley, 1993, A “hot spot” of recombination coincides with an interstitial telomeric sequence in the Armenian hamster, Cytogenet. Cell Genet., 62, 169, 10.1159\u002F000133464",{"doi":9045},"10.1159\u002F000133464",{"id":21,"text":9047,"url":21,"identifiers":9048},"Goyanes, 1995, High frequency of mutagen-induced chromatid exchanges at interstitial telomere-like DNA sequence blocks of Chinese hamster cells, Chromosome Res., 3, 281, 10.1007\u002FBF00713065",{"doi":9049},"10.1007\u002FBF00713065",{"id":21,"text":9051,"url":21,"identifiers":9052},"Day, 1998, Recombination involving interstitial telomere repeat-like sequences promotes chromosomal instability in Chinese hamster cells, Carcinogenesis, 19, 259, 10.1093\u002Fcarcin\u002F19.2.259",{"doi":9053},"10.1093\u002Fcarcin\u002F19.2.259",{"id":21,"text":9055,"url":21,"identifiers":9056},"Wood, 2015, A beginning of the end: New insights into the functional organization of telomeres, Nucleus, 6, 172, 10.1080\u002F19491034.2015.1048407",{"doi":9057},"10.1080\u002F19491034.2015.1048407",{"id":21,"text":9059,"url":21,"identifiers":9060},"Kilburn, 2001, Insertion of a telomere repeat sequence into a mammalian gene causes chromosome instability, Mol. Cell. Biol., 21, 126, 10.1128\u002FMCB.21.1.126-135.2001",{"doi":9061},"10.1128\u002FMCB.21.1.126-135.2001",{"id":21,"text":9063,"url":21,"identifiers":9064},"Aksenova, 2013, Genome rearrangements caused by interstitial telomeric sequences in yeast, Proc. Natl. Acad. Sci. USA, 110, 19866, 10.1073\u002Fpnas.1319313110",{"doi":9065},"10.1073\u002Fpnas.1319313110",{"id":21,"text":9067,"url":21,"identifiers":9068},"Aksenova, 2015, Expansion of Interstitial Telomeric Sequences in Yeast, Cell Rep., 13, 1545, 10.1016\u002Fj.celrep.2015.10.023",{"doi":9069},"10.1016\u002Fj.celrep.2015.10.023",{"id":21,"text":9071,"url":21,"identifiers":9072},"Berger, 2007, Jumping translocations, Genes Chromosomes Cancer, 46, 717, 10.1002\u002Fgcc.20456",{"doi":9073},"10.1002\u002Fgcc.20456",{"id":21,"text":9075,"url":21,"identifiers":9076},"Park, 1992, The presence of interstitial telomeric sequences in constitutional chromosome abnormalities, Am. J. Hum. Genet., 50, 914",{},{"id":21,"text":9078,"url":21,"identifiers":9079},"Rossi, 1993, Types, stability, and phenotypic consequences of chromosome rearrangements leading to interstitial telomeric sequences, J. Med. Genet., 30, 926, 10.1136\u002Fjmg.30.11.926",{"doi":9080},"10.1136\u002Fjmg.30.11.926",{"id":21,"text":9082,"url":21,"identifiers":9083},"Devriendt, 1997, Trisomy 15 rescue with jumping translocation of distal 15q in Prader-Willi syndrome, J. Med. Genet., 34, 395, 10.1136\u002Fjmg.34.5.395",{"doi":9084},"10.1136\u002Fjmg.34.5.395",{"id":21,"text":9086,"url":21,"identifiers":9087},"Vermeesch, 1997, Interstitial telomeric sequences at the junction site of a jumping translocation, Hum. Genet., 99, 735, 10.1007\u002Fs004390050440",{"doi":9088},"10.1007\u002Fs004390050440",{"id":21,"text":9090,"url":21,"identifiers":9091},"Depetris, 2007, Recurrent rearrangements in the proximal 15q11-q14 region: A new breakpoint cluster specific to unbalanced translocations, Eur. J. Hum. Genet., 15, 432, 10.1038\u002Fsj.ejhg.5201775",{"doi":9092},"10.1038\u002Fsj.ejhg.5201775",{"id":21,"text":9094,"url":21,"identifiers":9095},"Fortin, 2009, Frequency of chromosome healing and interstitial telomeres in 40 cases of constitutional abnormalities, Cytogenet. Genome Res., 125, 176, 10.1159\u002F000230002",{"doi":9096},"10.1159\u002F000230002",{"id":21,"text":9098,"url":21,"identifiers":9099},"Lefort, 2001, Cytogenetic and molecular study of a jumping translocation in a baby with Dandy-Walker malformation, J. Med. Genet., 38, 67, 10.1136\u002Fjmg.38.1.67",{"doi":9100},"10.1136\u002Fjmg.38.1.67",{"id":21,"text":9102,"url":21,"identifiers":9103},"Hatakeyama, 1998, Shortened telomeres involved in a case with a jumping translocation at 1q21, Blood, 91, 1514, 10.1182\u002Fblood.V91.5.1514",{"doi":9104},"10.1182\u002Fblood.V91.5.1514",{"id":21,"text":9106,"url":21,"identifiers":9107},"Cuthbert, 1999, Jumping translocation at 11q23 with MLL gene rearrangement and interstitial telomeric sequences, Genes Chromosomes Cancer, 24, 295, 10.1002\u002F(SICI)1098-2264(199904)24:4\u003C295::AID-GCC1>3.0.CO;2-8",{"doi":9108},"10.1002\u002F(SICI)1098-2264(199904)24:4\u003C295::AID-GCC1>3.0.CO;2-8",{"id":21,"text":9110,"url":21,"identifiers":9111},"Brizard, 2000, Interstitial telomere repeats in translocations of hematopoietic disorders, Leukemia, 14, 1630, 10.1038\u002Fsj.leu.2401876",{"doi":9112},"10.1038\u002Fsj.leu.2401876",{"id":21,"text":9114,"url":21,"identifiers":9115},"Boutouil, 1996, Fragile site and interstitial telomere repeat sequences at the fusion point of a de novo (Y;13) translocation, Hum. Genet., 98, 323, 10.1007\u002Fs004390050216",{"doi":9116},"10.1007\u002Fs004390050216",{"id":21,"text":9118,"url":21,"identifiers":9119},"Receveur, 2015, Involvement of interstitial telomeric sequences in two new cases of mosaicism for autosomal structural rearrangements, Am. J. Med. Genet. A, 167A, 428",{},{"id":21,"text":9121,"url":21,"identifiers":9122},"Marlet, 2017, Prenatal diagnosis of trisomy 2p due to terminal 2p duplication including interstitial telomeric sequences, Cytogenet. Genome Res., 153, 117, 10.1159\u002F000485392",{"doi":9123},"10.1159\u002F000485392",{"id":21,"text":9125,"url":21,"identifiers":9126},"Schleiermacher, 2005, Stepwise occurrence of a complex unbalanced translocation in neuroblastoma leading to insertion of a telomere sequence and late chromosome 17q gain, Oncogene, 24, 3377, 10.1038\u002Fsj.onc.1208486",{"doi":9127},"10.1038\u002Fsj.onc.1208486",{"id":21,"text":9129,"url":21,"identifiers":9130},"Bodvarsdottir, 2012, Dysfunctional telomeres in human BRCA2 mutated breast tumors and cell lines, Mutat. Res. Mol. Mech. Mutagen., 729, 90, 10.1016\u002Fj.mrfmmm.2011.10.002",{"doi":9131},"10.1016\u002Fj.mrfmmm.2011.10.002",{"id":21,"text":9133,"url":21,"identifiers":9134},"Goto, G.H., Zencir, S., Hirano, Y., Ogi, H., Ivessa, A., and Sugimoto, K. (2015). Binding of multiple Rap1 proteins stimulates chromosome breakage induction during DNA replication. PLoS Genet., 11.",{"doi":9135},"10.1371\u002Fjournal.pgen.1005283",{"id":21,"text":9137,"url":21,"identifiers":9138},"Larcher, M.V., Pasquier, E., MacDonald, R.S., and Wellinger, R.J. (2016). Ku Binding on telomeres occurs at sites distal from the physical chromosome ends. PLoS Genet., 12.",{"doi":9139},"10.1371\u002Fjournal.pgen.1006479",{"id":21,"text":9141,"url":21,"identifiers":9142},"Yang, 2011, Human telomeric proteins occupy selective interstitial sites, Cell Res., 21, 1013, 10.1038\u002Fcr.2011.39",{"doi":9143},"10.1038\u002Fcr.2011.39",{"id":21,"text":9145,"url":21,"identifiers":9146},"Ye, 2010, TRF2 and Apollo cooperate with topoisomerase 2α to protect human telomeres from replicative damage, Cell, 142, 230, 10.1016\u002Fj.cell.2010.05.032",{"doi":9147},"10.1016\u002Fj.cell.2010.05.032",{"id":21,"text":9149,"url":21,"identifiers":9150},"Depetris, 2002, A human interstitial telomere associates in vivo with specific TRF2 and TIN2 proteins, Eur. J. Hum. Genet., 10, 107, 10.1038\u002Fsj.ejhg.5200775",{"doi":9151},"10.1038\u002Fsj.ejhg.5200775",{"id":21,"text":9153,"url":21,"identifiers":9154},"Krutilina, 2001, A negative regulator of telomere-length protein TRF1 is associated with interstitial (TTAGGG)n blocks in immortal Chinese hamster ovary cells, Biochem. Biophys. Res. Commun., 280, 471, 10.1006\u002Fbbrc.2000.4143",{"doi":9155},"10.1006\u002Fbbrc.2000.4143",{"id":21,"text":9157,"url":21,"identifiers":9158},"Krutilina, 2003, Protection of internal (TTAGGG)n repeats in Chinese hamster cells by telomeric protein TRF1, Oncogene, 22, 6690, 10.1038\u002Fsj.onc.1206745",{"doi":9159},"10.1038\u002Fsj.onc.1206745",{"id":21,"text":9161,"url":21,"identifiers":9162},"Gu, 2017, Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis, Oncogene, 36, 1939, 10.1038\u002Fonc.2016.405",{"doi":9163},"10.1038\u002Fonc.2016.405",{"id":21,"text":9165,"url":21,"identifiers":9166},"Ilic, 2017, Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites, Epigenetics Chromatin, 10, 54, 10.1186\u002Fs13072-017-0160-2",{"doi":9167},"10.1186\u002Fs13072-017-0160-2",{"id":21,"text":9169,"url":21,"identifiers":9170},"Robin, 2014, Telomere position effect: Regulation of gene expression with progressive telomere shortening over long distances, Genes Dev., 28, 2464, 10.1101\u002Fgad.251041.114",{"doi":9171},"10.1101\u002Fgad.251041.114",{"id":21,"text":9173,"url":21,"identifiers":9174},"Robin, 2015, SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy, Genome Res., 25, 1781, 10.1101\u002Fgr.190660.115",{"doi":9175},"10.1101\u002Fgr.190660.115",{"id":21,"text":9177,"url":21,"identifiers":9178},"Grunstein, 1997, Molecular model for telomeric heterochromatin in yeast, Curr. Opin. Cell Biol., 9, 383, 10.1016\u002FS0955-0674(97)80011-7",{"doi":9179},"10.1016\u002FS0955-0674(97)80011-7",{"id":21,"text":9181,"url":21,"identifiers":9182},"Kim, W., Ludlow, A.T., Min, J., Robin, J.D., Stadler, G., Mender, I., Lai, T.-P., Zhang, N., Wright, W.E., and Shay, J.W. (2016). Regulation of the human telomerase gene TERT by telomere position effect—over long distances (TPE-OLD): Implications for aging and cancer. PLoS Biol., 14.",{"doi":9183},"10.1371\u002Fjournal.pbio.2000016",{"id":21,"text":9185,"url":21,"identifiers":9186},"Shay, 2018, Telomeres and aging, Curr. Opin. Cell Biol., 52, 1, 10.1016\u002Fj.ceb.2017.12.001",{"doi":9187},"10.1016\u002Fj.ceb.2017.12.001",{"id":21,"text":9189,"url":21,"identifiers":9190},"Mukherjee, A.K., Sharma, S., Sengupta, S., Saha, D., Kumar, P., Hussain, T., Srivastava, V., Roy, S.D., Shay, J.W., and Chowdhury, S. (2018). Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends. PLoS Genet., 14.",{"doi":9191},"10.1371\u002Fjournal.pgen.1007782",{"id":21,"text":9193,"url":21,"identifiers":9194},"Berthiau, 2006, Subtelomeric proteins negatively regulate telomere elongation in budding yeast, EMBO J., 25, 846, 10.1038\u002Fsj.emboj.7600975",{"doi":9195},"10.1038\u002Fsj.emboj.7600975",{"id":21,"text":9197,"url":21,"identifiers":9198},"Huettel, 2007, RNA-directed DNA methylation mediated by DRD1 and Pol IVb: A versatile pathway for transcriptional gene silencing in plants, Biochim. Biophys. Acta Gene Struct. Expr., 1769, 358, 10.1016\u002Fj.bbaexp.2007.03.001",{"doi":9199},"10.1016\u002Fj.bbaexp.2007.03.001",{"id":21,"text":9201,"url":21,"identifiers":9202},"Matzke, 2014, RNA-directed DNA methylation: An epigenetic pathway of increasing complexity, Nat. Rev. Genet., 15, 394, 10.1038\u002Fnrg3683",{"doi":9203},"10.1038\u002Fnrg3683",{"id":21,"text":9205,"url":21,"identifiers":9206},"Marcomini, 2018, Asymmetric processing of DNA ends at a double-strand break leads to unconstrained dynamics and ectopic translocation, Cell Rep., 24, 2614, 10.1016\u002Fj.celrep.2018.07.102",{"doi":9207},"10.1016\u002Fj.celrep.2018.07.102",{"id":21,"text":9209,"url":21,"identifiers":9210},"Moore, 2018, Genetic control of genomic alterations induced in yeast by interstitial telomeric sequences, Genetics, 209, 425, 10.1534\u002Fgenetics.118.300950",{"doi":9211},"10.1534\u002Fgenetics.118.300950",{"id":21,"text":9213,"url":21,"identifiers":9214},"Adam, 1991, Telomeric location of Giardia rDNA genes, Mol. Cell. Biol., 11, 3326",{},{"id":21,"text":9216,"url":21,"identifiers":9217},"Yu, 1991, Developmentally programmed healing of chromosomes by telomerase in Tetrahymena, Cell, 67, 823, 10.1016\u002F0092-8674(91)90077-C",{"doi":9218},"10.1016\u002F0092-8674(91)90077-C",{"id":21,"text":9220,"url":21,"identifiers":9221},"Butler, 1992, Ribosomal DNA is a site of chromosome breakage in aneuploid strains of Neurospora, Genetics, 131, 581, 10.1093\u002Fgenetics\u002F131.3.581",{"doi":9222},"10.1093\u002Fgenetics\u002F131.3.581",{"id":21,"text":9224,"url":21,"identifiers":9225},"Salvadori, 1995, Colocalization of (TTAGGG)n telomeric sequences and ribosomal genes in Atlantic eels, Chromosom. Res., 3, 54, 10.1007\u002FBF00711162",{"doi":9226},"10.1007\u002FBF00711162",{"id":21,"text":9228,"url":21,"identifiers":9229},"1996, Localization of the repetitive telomeric sequence (TTAGGG) n in four salmonid species, Genome, 39, 1035, 10.1139\u002Fg96-129",{"doi":9230},"10.1139\u002Fg96-129",{"id":21,"text":9232,"url":21,"identifiers":9233},"Copenhaver, 1996, RFLP and physical mapping with an rDNA-specific endonuclease reveals that nucleolus organizer regions of Arabidopsis thaliana adjoin the telomeres on chromosomes 2 and 4, Plant J., 9, 259, 10.1046\u002Fj.1365-313X.1996.09020259.x",{"doi":9234},"10.1046\u002Fj.1365-313X.1996.09020259.x",{"id":21,"text":9236,"url":21,"identifiers":9237},"Liu, 1999, Telomeric (TTAGGG)n sequences are associated with nucleolus organizer regions (NORs) in the wood lemming, Chromosom. Res., 7, 235, 10.1023\u002FA:1009255517764",{"doi":9238},"10.1023\u002FA:1009255517764",{"id":21,"text":9240,"url":21,"identifiers":9241},"Stimpson, K.M., Sullivan, L.L., Kuo, M.E., and Sullivan, B.A. (2014). Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function. PLoS ONE, 9.",{"doi":9242},"10.1371\u002Fjournal.pone.0092432",{"id":21,"text":9244,"url":21,"identifiers":9245},"Villasante, 2007, Centromeres were derived from telomeres during the evolution of the eukaryotic chromosome, Proc. Natl. Acad. Sci. USA, 104, 10542, 10.1073\u002Fpnas.0703808104",{"doi":9246},"10.1073\u002Fpnas.0703808104",{"id":21,"text":9248,"url":21,"identifiers":9249},"Rocchi, 2012, Centromere repositioning in mammals, Heredity, 108, 59, 10.1038\u002Fhdy.2011.101",{"doi":9250},"10.1038\u002Fhdy.2011.101",{"id":21,"text":9252,"url":21,"identifiers":9253},"Mirkin, 2007, Replication fork stalling at natural impediments, Microbiol. Mol. Biol. Rev., 71, 13, 10.1128\u002FMMBR.00030-06",{"doi":9254},"10.1128\u002FMMBR.00030-06",{"id":21,"text":9256,"url":21,"identifiers":9257},"Yu, 1999, Chromatin opening and transactivator potentiation by RAP1 in Saccharomyces cerevisiae, Mol. Cell. Biol., 19, 5279, 10.1128\u002FMCB.19.8.5279",{"doi":9258},"10.1128\u002FMCB.19.8.5279",{"id":21,"text":9260,"url":21,"identifiers":9261},"Morse, 2000, RAP, RAP, open up! New wrinkles for RAP1 in yeast, Trends Genet., 16, 51, 10.1016\u002FS0168-9525(99)01936-8",{"doi":9262},"10.1016\u002FS0168-9525(99)01936-8",{"id":21,"text":9264,"url":21,"identifiers":9265},"Xie, 2019, DNA fragility in the parallel evolution of pelvic reduction in stickleback fish, Science, 363, 81, 10.1126\u002Fscience.aan1425",{"doi":9266},"10.1126\u002Fscience.aan1425",{"id":21,"text":9268,"url":21,"identifiers":9269},"Labib, 2007, Replication fork barriers: Pausing for a break or stalling for time?, EMBO Rep., 8, 346, 10.1038\u002Fsj.embor.7400940",{"doi":9270},"10.1038\u002Fsj.embor.7400940",{"id":21,"text":9272,"url":21,"identifiers":9273},"Hodgson, 2007, Mrc1 and Tof1 regulate DNA replication forks in different ways during normal S phase, Mol. Biol. Cell, 18, 3894, 10.1091\u002Fmbc.e07-05-0500",{"doi":9274},"10.1091\u002Fmbc.e07-05-0500",{"id":21,"text":9276,"url":21,"identifiers":9277},"Leman, 2012, Timeless preserves telomere length by promoting efficient DNA replication through human telomeres, Cell Cycle, 11, 2337, 10.4161\u002Fcc.20810",{"doi":9278},"10.4161\u002Fcc.20810",{"id":21,"text":9280,"url":21,"identifiers":9281},"Gadaleta, M.C., Das, M.M., Tanizawa, H., Chang, Y.-T., Noma, K., Nakamura, T.M., and Noguchi, E. (2016). Swi1Timeless prevents repeat instability at fission yeast telomeres. PLoS Genet., 12.",{"doi":9282},"10.1371\u002Fjournal.pgen.1005943",{"id":21,"text":9284,"url":21,"identifiers":9285},"Mazzoccoli, 2012, Altered expression of the clock gene machinery in kidney cancer patients, Biomed. Pharmacother., 66, 175, 10.1016\u002Fj.biopha.2011.11.007",{"doi":9286},"10.1016\u002Fj.biopha.2011.11.007",{"id":21,"text":9288,"url":21,"identifiers":9289},"Mao, Y., Fu, A., Leaderer, D., Zheng, T., Chen, K., and Zhu, Y. (2013). Potential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analyses. BMC Cancer, 13.",{"doi":9290},"10.1186\u002F1471-2407-13-498",{"id":21,"text":9292,"url":21,"identifiers":9293},"Relles, 2013, Circadian gene expression and clinicopathologic correlates in pancreatic cancer, J. Gastrointest. Surg., 17, 443, 10.1007\u002Fs11605-012-2112-2",{"doi":9294},"10.1007\u002Fs11605-012-2112-2",{"id":21,"text":9296,"url":21,"identifiers":9297},"Baldeyron, 2015, TIPIN depletion leads to apoptosis in breast cancer cells, Mol. Oncol., 9, 1580, 10.1016\u002Fj.molonc.2015.04.010",{"doi":9298},"10.1016\u002Fj.molonc.2015.04.010",{"id":21,"text":9300,"url":21,"identifiers":9301},"Chi, 2017, TIMELESS contributes to the progression of breast cancer through activation of MYC, Breast Cancer Res., 19, 53, 10.1186\u002Fs13058-017-0838-1",{"doi":9302},"10.1186\u002Fs13058-017-0838-1",{"id":21,"text":9304,"url":21,"identifiers":9305},"Zhang, 2017, Aberrant TIMELESS expression is associated with poor clinical survival and lymph node metastasis in early-stage cervical carcinoma, Int. J. Oncol., 50, 173, 10.3892\u002Fijo.2016.3784",{"doi":9306},"10.3892\u002Fijo.2016.3784",{"id":21,"text":9308,"url":21,"identifiers":9309},"Parenteau, 1999, Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27, Mol. Cell. Biol., 19, 4143, 10.1128\u002FMCB.19.6.4143",{"doi":9310},"10.1128\u002FMCB.19.6.4143",{"id":21,"text":9312,"url":21,"identifiers":9313},"Saharia, 2008, Flap endonuclease 1 contributes to telomere stability, Curr. Biol., 18, 496, 10.1016\u002Fj.cub.2008.02.071",{"doi":9314},"10.1016\u002Fj.cub.2008.02.071",{"id":21,"text":9316,"url":21,"identifiers":9317},"Moser, 2009, Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres, EMBO J., 28, 810, 10.1038\u002Femboj.2009.31",{"doi":9318},"10.1038\u002Femboj.2009.31",{"id":21,"text":9320,"url":21,"identifiers":9321},"Gatbonton, T., Imbesi, M., Nelson, M., Akey, J.M., Ruderfer, D.M., Kruglyak, L., Simon, J.A., and Bedalov, A. (2006). Telomere length as a quantitative trait: Genome-wide survey and genetic mapping of telomere length-control genes in yeast. PLoS Genet., 2.",{"doi":9322},"10.1371\u002Fjournal.pgen.0020104",{"id":21,"text":9324,"url":21,"identifiers":9325},"Fallet, 2014, Length-dependent processing of telomeres in the absence of telomerase, Nucleic Acids Res., 42, 3648, 10.1093\u002Fnar\u002Fgkt1328",{"doi":9326},"10.1093\u002Fnar\u002Fgkt1328",{"id":21,"text":9328,"url":21,"identifiers":9329},"Johnson, 1992, Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome, Mol. Cell. Biol., 12, 3807",{},{"id":21,"text":9331,"url":21,"identifiers":9332},"Luke-Glaser, S., and Luke, B. (2012). The Mph1 helicase can promote telomere uncapping and premature senescence in budding yeast. PLoS ONE, 7.",{"doi":9333},"10.1371\u002Fjournal.pone.0042028",{"id":21,"text":9335,"url":21,"identifiers":9336},"Donnianni, 2014, Template switching during break-induced replication is promoted by the mph1 helicase in Saccharomyces cerevisiae, Genetics, 196, 1017, 10.1534\u002Fgenetics.114.162297",{"doi":9337},"10.1534\u002Fgenetics.114.162297",{"id":21,"text":9339,"url":21,"identifiers":9340},"Motegi, 2008, Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks, Proc. Natl. Acad. Sci. USA, 105, 12411, 10.1073\u002Fpnas.0805685105",{"doi":9341},"10.1073\u002Fpnas.0805685105",{"id":21,"text":9343,"url":21,"identifiers":9344},"Unk, 2010, Role of yeast Rad5 and its human orthologs, HLTF and SHPRH in DNA damage tolerance, DNA Repair, 9, 257, 10.1016\u002Fj.dnarep.2009.12.013",{"doi":9345},"10.1016\u002Fj.dnarep.2009.12.013",{"id":21,"text":9347,"url":21,"identifiers":9348},"Vannier, 2013, RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication, Science, 342, 239, 10.1126\u002Fscience.1241779",{"doi":9349},"10.1126\u002Fscience.1241779",{"id":21,"text":9351,"url":21,"identifiers":9352},"Vannier, 2012, RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity, Cell, 149, 795, 10.1016\u002Fj.cell.2012.03.030",{"doi":9353},"10.1016\u002Fj.cell.2012.03.030",{"id":21,"text":9355,"url":21,"identifiers":9356},"Ballew, B.J., Joseph, V., De, S., Sarek, G., Vannier, J.-B., Stracker, T., Schrader, K.A., Small, T.N., O’Reilly, R., and Manschreck, C. (2013). A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome. PLoS Genet., 9.",{"doi":9357},"10.1371\u002Fjournal.pgen.1003695",{"id":21,"text":9359,"url":21,"identifiers":9360},"Deng, 2013, Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome, Proc. Natl. Acad. Sci. USA, 110, E3408, 10.1073\u002Fpnas.1300600110",{"doi":9361},"10.1073\u002Fpnas.1300600110",{"id":21,"text":9363,"url":21,"identifiers":9364},"Pan, 2017, FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres, Proc. Natl. Acad. Sci. USA, 114, E5940, 10.1073\u002Fpnas.1708065114",{"doi":9365},"10.1073\u002Fpnas.1708065114",{"id":21,"text":9367,"url":21,"identifiers":9368},"Neil, 2017, Precarious maintenance of simple DNA repeats in eukaryotes, BioEssays, 39, 1700077, 10.1002\u002Fbies.201700077",{"doi":9369},"10.1002\u002Fbies.201700077"]