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O\u003Cjats:sub>2\u003C\u002Fjats:sub>\u003Cjats:sup>−\u003C\u002Fjats:sup> in cytosolic, extracellular, and mitochondrial pools is detoxified by dedicated superoxide dismutase (SOD) isoforms. We tested the impact of each SOD isoform in \u003Cjats:italic>Caenorhabditis elegans\u003C\u002Fjats:italic> by manipulating its five \u003Cjats:italic>sod\u003C\u002Fjats:italic> genes and saw no major effects on life span. \u003Cjats:italic>sod\u003C\u002Fjats:italic> genes are not required for \u003Cjats:italic>daf-2\u003C\u002Fjats:italic> insulin\u002FIGF-1 receptor mutant longevity. However, loss of the extracellular Cu\u002FZnSOD \u003Cjats:italic>sod-4\u003C\u002Fjats:italic> enhances \u003Cjats:italic>daf-2\u003C\u002Fjats:italic> longevity and constitutive diapause, suggesting a signaling role for \u003Cjats:italic>sod-4\u003C\u002Fjats:italic>. 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Soc., 20, 145, 10.1111\u002Fj.1532-5415.1972.tb00787.x",{"doi":342},"10.1111\u002Fj.1532-5415.1972.tb00787.x",{"id":24,"text":344,"url":24,"identifiers":345},"Honda,, 1999, The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans, FASEB J., 13, 1385, 10.1096\u002Ffasebj.13.11.1385",{"doi":346},"10.1096\u002Ffasebj.13.11.1385",{"id":24,"text":348,"url":24,"identifiers":349},"Honda,, 2008, Modulation of longevity and diapause by redox regulation mechanisms under the insulin-like signaling control in Caenorhabditis elegans, Exp. Gerontol., 43, 520, 10.1016\u002Fj.exger.2008.02.009",{"doi":350},"10.1016\u002Fj.exger.2008.02.009",{"id":24,"text":352,"url":24,"identifiers":353},"Huang,, 2000, Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice, J. Gerontol., 55, B5, 10.1093\u002Fgerona\u002F55.1.B5",{"doi":354},"10.1093\u002Fgerona\u002F55.1.B5",{"id":24,"text":356,"url":24,"identifiers":357},"10.1074\u002Fjbc.272.45.28652",{"doi":356},{"id":24,"text":359,"url":24,"identifiers":360},"10.1074\u002Fjbc.M509142200",{"doi":359},{"id":24,"text":362,"url":24,"identifiers":363},"10.1016\u002Fj.cell.2005.02.002",{"doi":362},{"id":24,"text":365,"url":24,"identifiers":366},"10.1073\u002Fpnas.90.19.8905",{"doi":365},{"id":24,"text":368,"url":24,"identifiers":369},"Lenaerts,, 2002, A high-throughput microtiter plate assay for superoxide dismutase based on lucigenin chemiluminescence, Anal. 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We explored the pathogenic content of this harmful pathogen using a combination of DNA sequencing and insertional mutagenesis. The genome of this organism was sequenced using a strategy involving high-density pyrosequencing, a novel, rapid method of high-throughput sequencing. Excluding the rDNA repeats, the assembled genome is 3,976,746 base pairs (bp) and has 3830 ORFs. A significant fraction of ORFs (17.2%) are located in 28 putative alien islands, indicating that the genome has acquired a large amount of foreign DNA. Consistent with its role in pathogenesis, a remarkable number of the islands (16) contain genes implicated in virulence, indicating the organism devotes a considerable portion of its genes to pathogenesis. The largest island contains elements homologous to the Legionella\u002FCoxiella Type IV secretion apparatus. Type IV secretion systems have been demonstrated to be important for virulence in other organisms and thus are likely to help mediate pathogenesis of \u003Cjats:italic>A. baumannii\u003C\u002Fjats:italic>. Insertional mutagenesis generated avirulent isolates of \u003Cjats:italic>A. baumannii\u003C\u002Fjats:italic> and verified that six of the islands contain virulence genes, including two novel islands containing genes that lacked homology with others in the databases. The DNA sequencing approach described in this study allows the rapid elucidation of the DNA sequence of any microbe and, when combined with genetic screens, can identify many novel genes important for microbial pathogenesis.\u003C\u002Fjats:p>",{"EN":438},"New insights into \u003Ci>Acinetobacter baumannii\u003C\u002Fi> pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis",{"VOID":440},"17344419",{"VOID":442},"10.1101\u002Fgad.1510307","VERIFIED","Auto Verify",[136],"http:\u002F\u002Fgenesdev.cshlp.org\u002Flookup\u002Fdoi\u002F10.1101\u002Fgad.1510307",[448,470,487,507,538,561,584],{"id":449,"sortIndex":236,"researcher":24,"roles":450,"affiliations":451,"properties":463},"21be7ec4-4a20-4438-97aa-7b09f944fec1",[],[452],{"id":453,"sortIndex":25,"affiliation":454,"properties":24},"b73a23d2-81d3-46e3-a048-e693e1ce1ab0",{"id":455,"createTime":456,"updateTime":457,"relativeEntities":458,"slug":459,"properties":460,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"271aec84-4611-431d-94b3-2a53614557d3","2023-11-28T23:17:04.735+00:00","2024-10-07T23:56:35.774+00:00",[],"Harvard-Medical-School-Department-of-Microbiology-and-Molecular-Genetics-Boston-Massachusetts-02115-USA",{"title":461},{"VI":462},"Harvard Medical School Department of Microbiology and Molecular Genetics Boston, Massachusetts 02115, USA",{"openalex":464,"orcid":466,"title":468},{"VOID":465},"A5045253972",{"VOID":467},"https:\u002F\u002Forcid.org\u002F0000-0003-2792-9293",{"EN":469},"John J. 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This subunit displays weakstructure-specific endonuclease activity on its own, is stimulated 500-fold by Slx4, and requires the PHD finger for activity in vitro and in vivo. Both subunits are required in vivo for resistance to DNA damage by methylmethane sulfonate (MMS). 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We have shown previously that yeast cells lacking\u003Cjats:italic>SGS1\u003C\u002Fjats:italic> or \u003Cjats:italic>TOP3\u003C\u002Fjats:italic> require \u003Cjats:italic>MMS4\u003C\u002Fjats:italic> and \u003Cjats:italic>MUS81\u003C\u002Fjats:italic> for viability. Here we show that Mms4 and Mus81 form a heterodimeric structure-specific endonuclease that cleaves branched DNA. Both subunits are required for optimal expression, substrate binding, and nuclease activity. Mms4 and Mus81 are conserved proteins related to the Rad1–Rad10 (XPF\u002FERCC1) endonuclease required for nucleotide excision repair (NER). However, the Mms4–Mus81 endonuclease is 25 times more active on branched duplex DNA and replication fork substrates than simple Y-forms, the preferred substrate for the NER complexes. We also present genetic data that indicate a novel role for Mms4–Mus81 in meiotic recombination. Our results suggest that stalled replication forks are substrates for Mms4–Mus81 cleavage—particularly in the absence of Sgs1 or BLM. Repair of this double-strand break (DSB) by homologous recombination may be responsible for the elevated levels of sister chromatid exchange (SCE) found in BLM\u003Cjats:sup>−\u002F−\u003C\u002Fjats:sup> cells.\u003C\u002Fjats:p>",{"EN":1636},"Functional overlap between Sgs1–Top3 and the Mms4–Mus81 endonuclease",{"VOID":1638},"11641278",{"VOID":982},[136],"http:\u002F\u002Fgenesdev.cshlp.org\u002Flookup\u002Fdoi\u002F10.1101\u002Fgad.932201",[1643,1663,1676,1691,1708],{"id":1644,"sortIndex":224,"researcher":24,"roles":1645,"affiliations":1646,"properties":1658},"9724e1e1-febc-4835-91a7-a62802865016",[],[1647],{"id":1648,"sortIndex":25,"affiliation":1649,"properties":24},"f7014942-c6c3-4ed4-bc01-611d41d1c942",{"id":1650,"createTime":1651,"updateTime":1652,"relativeEntities":1653,"slug":1654,"properties":1655,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"ac16ae9d-16a5-4c45-93e0-97798187f852","2023-12-07T21:32:28.283+00:00","2024-12-25T23:56:03.383+00:00",[],"Department-of-Molecular-Biology-and-Biochemistry-Center-for-Advanced-Biotechnology-and-Medicine-Rutgers-University-Piscataway-New-Jersey-08854-USA",{"title":1656},{"VI":1657},"Department of Molecular Biology and Biochemistry, Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, USA",{"openalex":1659,"title":1661},{"VOID":1660},"A5069405349",{"EN":1662},"Janet R. 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Biol. Chem., 263, 13366, 10.1016\u002FS0021-9258(18)37713-5",{"doi":943},{"id":24,"text":957,"url":24,"identifiers":1803},{"doi":957},{"id":24,"text":1805,"url":24,"identifiers":1806},"Gangloff, 1994, The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: A potential eukaryotic reverse gyrase., Mol. Cell. Biol., 14, 8391",{},{"id":24,"text":1415,"url":24,"identifiers":1808},{"doi":1415},{"id":24,"text":1810,"url":24,"identifiers":1811},"10.1002\u002F(SICI)1097-0061(199910)15:14\u003C1541::AID-YEA476>3.0.CO;2-K",{"doi":1810},{"id":24,"text":1813,"url":24,"identifiers":1814},"10.1093\u002Fnar\u002F27.20.4050",{"doi":1813},{"id":24,"text":1816,"url":24,"identifiers":1817},"10.1093\u002Fnar\u002F24.13.2519",{"doi":1816},{"id":24,"text":1819,"url":24,"identifiers":1820},"10.1038\u002F371531a0",{"doi":1819},{"id":24,"text":966,"url":24,"identifiers":1822},{"doi":966},{"id":24,"text":1824,"url":24,"identifiers":1825},"10.1046\u002Fj.1365-2443.1999.00288.x",{"doi":1824},{"id":24,"text":969,"url":24,"identifiers":1827},{"doi":969},{"id":24,"text":1829,"url":24,"identifiers":1830},"10.1038\u002F2410",{"doi":1829},{"id":24,"text":1832,"url":24,"identifiers":1833},"10.1007\u002Fs004380000241",{"doi":1832},{"id":24,"text":1835,"url":24,"identifiers":1836},"Johnson, 2000, Association of the Bloom syndrome protein with topoisomerase IIIα in somatic and meiotic cells., Cancer Res., 60, 1162",{},{"id":24,"text":1838,"url":24,"identifiers":1839},"Kadyk, 1993, Replication-dependent sister chromatid recombination in rad1 mutants of Saccharomyces cerevisiae., Genetics, 133, 469, 10.1093\u002Fgenetics\u002F133.3.469",{"doi":1840},"10.1093\u002Fgenetics\u002F133.3.469",{"id":24,"text":1455,"url":24,"identifiers":1842},{"doi":1455},{"id":24,"text":1844,"url":24,"identifiers":1845},"Kim, 1992, Identification of the yeast TOP3 gene product as a single strand-specific DNA topoisomerase., J. Biol. Chem., 267, 17178, 10.1016\u002FS0021-9258(18)41910-2",{"doi":990},{"id":24,"text":1847,"url":24,"identifiers":1848},"10.1074\u002Fjbc.274.53.37795",{"doi":1847},{"id":24,"text":1850,"url":24,"identifiers":1851},"Malone, 1981, Recombinationless meiosis in Saccharomyces cerevisiae., Mol. Cell. Biol., 1, 891",{},{"id":24,"text":1853,"url":24,"identifiers":1854},"Mullen, 2000, Bipartite structure of the SGS1 DNA helicase in Saccharomyces cerevisiae., Genetics, 154, 1101, 10.1093\u002Fgenetics\u002F154.3.1101",{"doi":1003},{"id":24,"text":1856,"url":24,"identifiers":1857},"Mullen, 2001, Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae., Genetics, 157, 103, 10.1093\u002Fgenetics\u002F157.1.103",{"doi":1007},{"id":24,"text":1859,"url":24,"identifiers":1860},"Paques, 1999, Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae., Microbiol. Mol. Biol. Rev., 63, 349, 10.1128\u002FMMBR.63.2.349-404.1999",{"doi":1538},{"id":24,"text":1862,"url":24,"identifiers":1863},"10.1073\u002Fpnas.91.11.5017",{"doi":1862},{"id":24,"text":1865,"url":24,"identifiers":1866},"10.1038\u002F30037",{"doi":1865},{"id":24,"text":1868,"url":24,"identifiers":1869},"10.1074\u002Fjbc.271.34.20551",{"doi":1868},{"id":24,"text":1871,"url":24,"identifiers":1872},"Rose M.D. Winston F. Hieter P. (1990) Methods in yeast genetics. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY).",{},{"id":24,"text":1874,"url":24,"identifiers":1875},"10.1016\u002FS0092-8674(00)81772-9",{"doi":1874},{"id":24,"text":1028,"url":24,"identifiers":1877},{"doi":1028},{"id":24,"text":1879,"url":24,"identifiers":1880},"10.1016\u002F0076-6879(90)85008-C",{"doi":1879},{"id":24,"text":1882,"url":24,"identifiers":1883},"Wang, 1991, DNA topoisomerases: Why so many?, J. Biol. Chem., 266, 6659, 10.1016\u002FS0021-9258(20)89545-3",{"doi":1048},{"id":24,"text":1885,"url":24,"identifiers":1886},"10.1016\u002F0092-8674(90)90002-V",{"doi":1885},{"id":24,"text":1888,"url":24,"identifiers":1889},"Watt, 1996, SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae., Genetics, 144, 935, 10.1093\u002Fgenetics\u002F144.3.935",{"doi":1055},{"id":24,"text":1057,"url":24,"identifiers":1891},{"doi":1057},{"id":24,"text":1060,"url":24,"identifiers":1893},{"doi":1060},{"id":24,"text":1895,"url":24,"identifiers":1896},"10.1007\u002Fs004380050689",{"doi":1895},{"id":24,"text":1898,"url":24,"identifiers":1899},"10.1038\u002Fsj.onc.1203367",{"doi":1898},{"id":1901,"createTime":1902,"updateTime":1902,"relativeEntities":1903,"slug":1904,"properties":1905,"entityType":133,"verifyStatus":443,"verifyTime":1902,"verifyNote":444,"syncStatus":23,"languages":1921,"translateLanguages":24,"viewCount":25,"primaryUrl":1922,"fullTextUrl":24,"authors":1923,"publicationType":244,"publisherRelationship":1967,"citationCount":1998,"citationInfo":1999,"publishDate":884,"publishYear":885,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":2001,"isForceReanalyzing":421},"f42986f4-ec3b-4cd0-9bad-645acb08373e","2024-12-25T23:56:02.714+00:00",[],"Chromosome-integrity-in-i-Saccharomyces-cerevisiae-i-the-interplay-of-DNA-replication-initiation-factors-elongation-factors-and-origins",{"mag":1906,"keywords":1908,"pmc":1909,"openalex":1911,"abstract":1913,"title":1915,"pm":1917,"doi":1919},{"VOID":1907},"2033517491",{},{"VOID":1910},"196182",{"VOID":1912},"W2033517491",{"EN":1914},"\u003Cjats:p>The integrity of chromosomes during cell division is ensured by both\u003Cjats:italic>trans\u003C\u002Fjats:italic>-acting factors and\u003Cjats:italic>cis\u003C\u002Fjats:italic>-acting chromosomal sites. Failure of either these chromosome integrity determinants (CIDs) can cause chromosomes to be broken and subsequently misrepaired to form gross chromosomal rearrangements (GCRs). We developed a simple and rapid assay for GCRs, exploiting yeast artificial chromosomes (YACs) in\u003Cjats:italic>Saccharomyces cerevisiae\u003C\u002Fjats:italic>. We used this assay to screen a genome-wide pool of mutants for elevated rates of GCR. The analyses of these mutants define new CIDs (Orc3p, Orc5p, and Ycs4p) and new pathways required for chromosome integrity in DNA replication elongation (Dpb11p), DNA replication initiation (Orc3p and Orc5p), and mitotic condensation (Ycs4p). We show that the chromosome integrity function of Orc5p is associated with its ATP-binding motif and is distinct from its function in controlling the efficiency of initiation of DNA replication. Finally, we used our YAC assay to assess the interplay of\u003Cjats:italic>trans\u003C\u002Fjats:italic>and\u003Cjats:italic>cis\u003C\u002Fjats:italic>factors in chromosome integrity. Increasing the number of origins on a YAC suppresses GCR formation in our\u003Cjats:italic>dpb11\u003C\u002Fjats:italic>mutant but enhances it in our\u003Cjats:italic>orc\u003C\u002Fjats:italic>mutants. This result provides potential insights into the counterbalancing selective pressures necessary for the evolution of origin density on chromosomes.\u003C\u002Fjats:p>",{"EN":1916},"Chromosome integrity in\u003Ci>Saccharomyces cerevisiae\u003C\u002Fi>: the interplay of DNA replication initiation factors, elongation factors, and 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Institution of Washington, Department of Embryology, Baltimore, Maryland , Johns Hopkins University, Department of Biology, Baltimore, Maryland 21218, USA",{"openalex":1939,"orcid":1941,"title":1943},{"VOID":1940},"A5055710477",{"VOID":1942},"https:\u002F\u002Forcid.org\u002F0000-0003-4053-0148",{"EN":1944},"Dongli 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Biol., 17, 7159, 10.1128\u002FMCB.17.12.7159",{"doi":2068},"10.1128\u002FMCB.17.12.7159",{"id":24,"text":2070,"url":24,"identifiers":2071},"10.1016\u002FS1097-2765(02)00513-0",{"doi":2070},{"id":24,"text":2073,"url":24,"identifiers":2074},"10.1016\u002F0092-8674(95)90528-6",{"doi":2073},{"id":24,"text":2076,"url":24,"identifiers":2077},"10.1091\u002Fmbc.6.6.741",{"doi":2076},{"id":24,"text":2079,"url":24,"identifiers":2080},"10.1128\u002FMCB.20.8.2809-2817.2000",{"doi":2079},{"id":24,"text":2082,"url":24,"identifiers":2083},"10.1073\u002Fpnas.25.8.405",{"doi":2082},{"id":24,"text":2085,"url":24,"identifiers":2086},"10.1016\u002FS0968-0004(00)01560-7",{"doi":2085},{"id":24,"text":1511,"url":24,"identifiers":2088},{"doi":1511},{"id":24,"text":2090,"url":24,"identifiers":2091},"10.1038\u002F35082608",{"doi":2090},{"id":24,"text":2093,"url":24,"identifiers":2094},"10.1016\u002FS0092-8674(01)00227-6",{"doi":2093},{"id":24,"text":2096,"url":24,"identifiers":2097},"Newlon C . and Burke, W. 1980. Replication of small chromosomal DNAs in yeast. In Mechanistic studies of DNA replication and recombination (eds. B. Alberts and C. Fox), pp. 399–409. Academic Press, New York.",{"doi":2098},"10.1016\u002FB978-0-12-048850-6.50042-9",{"id":24,"text":2100,"url":24,"identifiers":2101},"2001, Development, 128, 1697, 10.1242\u002Fdev.128.9.1697",{"doi":2102},"10.1242\u002Fdev.128.9.1697",{"id":24,"text":2104,"url":24,"identifiers":2105},"10.1091\u002Fmbc.12.11.3317",{"doi":2104},{"id":24,"text":2107,"url":24,"identifiers":2108},"10.1073\u002Fpnas.96.20.11440",{"doi":2107},{"id":24,"text":2110,"url":24,"identifiers":2111},"2000, Genetics, 155, 475, 10.1093\u002Fgenetics\u002F155.1.475",{"doi":2112},"10.1093\u002Fgenetics\u002F155.1.475",{"id":24,"text":1018,"url":24,"identifiers":2114},{"doi":1020},{"id":24,"text":2116,"url":24,"identifiers":2117},"10.1016\u002F0092-8674(84)90301-5",{"doi":2116},{"id":24,"text":2119,"url":24,"identifiers":2120},"10.1080\u002F095530098142653",{"doi":2119},{"id":24,"text":2122,"url":24,"identifiers":2123},"10.1006\u002Fgeno.1994.1352",{"doi":2122},{"id":24,"text":2125,"url":24,"identifiers":2126},"10.1101\u002Fgad.1011002",{"doi":2125},{"id":24,"text":2128,"url":24,"identifiers":2129},"10.1002\u002F(SICI)1097-0061(199602)12:2\u003C101::AID-YEA885>3.0.CO;2-2",{"doi":2128},{"id":24,"text":2131,"url":24,"identifiers":2132},"2002, Genetics, 160, 1363, 10.1093\u002Fgenetics\u002F160.4.1363",{"doi":2133},"10.1093\u002Fgenetics\u002F160.4.1363",{"id":24,"text":2135,"url":24,"identifiers":2136},"1999, Mol. Cell. Biol., 19, 4231, 10.1128\u002FMCB.19.6.4231",{"doi":2137},"10.1128\u002FMCB.19.6.4231",{"id":24,"text":2139,"url":24,"identifiers":2140},"10.1016\u002FS1097-2765(01)00216-7",{"doi":2139},{"id":24,"text":2142,"url":24,"identifiers":2143},"10.1073\u002Fpnas.96.7.3824",{"doi":2142},{"id":24,"text":2145,"url":24,"identifiers":2146},"10.1083\u002Fjcb.133.1.85",{"doi":2145},{"id":2148,"createTime":2149,"updateTime":2149,"relativeEntities":2150,"slug":2151,"properties":2152,"entityType":133,"verifyStatus":443,"verifyTime":2166,"verifyNote":444,"syncStatus":23,"languages":2167,"translateLanguages":24,"viewCount":25,"primaryUrl":2168,"fullTextUrl":24,"authors":2169,"publicationType":244,"publisherRelationship":2248,"citationCount":2281,"citationInfo":2282,"publishDate":2284,"publishYear":2285,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":2286,"isForceReanalyzing":421},"92324f82-d267-487c-8f0b-f937b3ff7f55","2024-09-30T23:55:44.366+00:00",[],"Activation-and-repression-of-mammalian-gene-expression-by-the-c-myc-protein-",{"mag":2153,"keywords":2155,"openalex":2156,"abstract":2158,"title":2160,"pm":2162,"doi":2164},{"VOID":2154},"2054876743",{},{"VOID":2157},"W2054876743",{"EN":2159},"\u003Cjats:p>One mechanism by which nuclear-localized oncogenes might transform cells is through an ability to regulate gene expression. We show that the c-myc protein stimulates the level of appropriately initiated expression from the human heat shock protein 70 (hsp70) promoter. Sequences required for full activation lie upstream of the transcription initiation site and are distinct from sequences necessary for basal expression. These sequences also appear distinct from promoter sequences necessary for heat induction, serum induction, and induction by the papovavirus T antigens. The c-myc protein inhibits appropriately initiated expression from the mouse metallothionein I (MT-I) promoter. A mutation that removes 138 amino acids of exon 2 produces a c-myc gene product that is capable of activating the hsp70 promoter but is no longer capable of inhibiting MT-I expression, suggesting that these two properties reside in different domains of the c-myc protein. Expression from the adenovirus EII promoter is slightly inhibited, while expression from the SV40 early promoter is minimally affected by the c-myc protein. Both the spectrum of promoters regulated by the c-myc protein and the sequence requirements for that regulation differ from those of previously characterized viral trans-activating proteins. The data suggest that the c-myc protein can both stimulate and inhibit transcription from mammalian promoters in a novel manner.\u003C\u002Fjats:p>",{"EN":2161},"Activation and repression of mammalian gene expression by the c-myc protein.",{"VOID":2163},"3678827",{"VOID":2165},"10.1101\u002Fgad.1.4.347","2024-09-30T23:55:44.365+00:00",[136],"http:\u002F\u002Fgenesdev.cshlp.org\u002Flookup\u002Fdoi\u002F10.1101\u002Fgad.1.4.347",[2170,2189,2210,2227],{"id":2171,"sortIndex":224,"researcher":24,"roles":2172,"affiliations":2173,"properties":2184},"5f3c35b4-29de-4024-9e7e-d9b7158b400f",[],[2174],{"id":2175,"sortIndex":25,"affiliation":2176,"properties":24},"8eb5e2b2-de7f-4e4a-8425-d3f7db60ff2b",{"id":2177,"createTime":2178,"updateTime":2178,"relativeEntities":2179,"slug":2180,"properties":2181,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"e5b36d58-8ff0-4744-a50d-a8588eb557fd","2026-03-24T03:55:02.806+00:00",[],"Harvard-University",{"title":2182},{"EN":2183},"Harvard University",{"openalex":2185,"title":2187},{"VOID":2186},"A5087611452",{"EN":2188},"J. 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Greene",{"id":2190,"sortIndex":25,"researcher":24,"roles":2191,"affiliations":2192,"properties":2203},"3b00bcb5-d986-4998-a4bf-58ec1567bccd",[],[2193],{"id":2194,"sortIndex":25,"affiliation":2195,"properties":24},"04f49d1f-9d8a-4dfe-bd25-60d7cc06d653",{"id":2196,"createTime":2197,"updateTime":2197,"relativeEntities":2198,"slug":2199,"properties":2200,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"5064e0a1-5e17-42a2-9037-2c7d586fc074","2024-09-30T23:55:44.392+00:00",[],"Department-of-Genetics-Harvard-Medical-School-Massachusetts-General-Hospital-Boston-02114-",{"title":2201},{"EN":2202},"Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston 02114.",{"openalex":2204,"orcid":2206,"title":2208},{"VOID":2205},"A5025091889",{"VOID":2207},"https:\u002F\u002Forcid.org\u002F0000-0003-1858-5732",{"EN":2209},"Rima Kaddurah‐Daouk",{"id":2211,"sortIndex":236,"researcher":24,"roles":2212,"affiliations":2213,"properties":2220},"75f61d29-87bb-4491-88ec-63fd8ea9c109",[],[2214],{"id":2215,"sortIndex":25,"affiliation":2216,"properties":24},"785ec854-1310-4c66-ae47-1d4faa1d250c",{"id":2177,"createTime":2178,"updateTime":2178,"relativeEntities":2217,"slug":2180,"properties":2218,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2219},{"EN":2183},{"openalex":2221,"orcid":2223,"title":2225},{"VOID":2222},"A5014149423",{"VOID":2224},"https:\u002F\u002Forcid.org\u002F0000-0003-3628-4335",{"EN":2226},"Robert E. Kingston",{"id":2228,"sortIndex":161,"researcher":24,"roles":2229,"affiliations":2230,"properties":2241},"c8498067-48bc-4306-af6c-abfef38dba59",[],[2231],{"id":2232,"sortIndex":25,"affiliation":2233,"properties":24},"f831b24d-ab4a-4eaa-81b9-bd7e21e72b8e",{"id":2234,"createTime":2235,"updateTime":2236,"relativeEntities":2237,"slug":2238,"properties":2239,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"5b4ccb8e-2317-4be3-858d-c6466076d896","2024-04-11T12:35:27.470+00:00","2026-06-19T02:10:36.534+00:00",[],"Biology",{"title":2240},{"EN":2238},{"openalex":2242,"orcid":2244,"title":2246},{"VOID":2243},"A5034236608",{"VOID":2245},"https:\u002F\u002Forcid.org\u002F0000-0003-1246-1333",{"EN":2247},"Albert S. Baldwin",{"url":24,"publisher":2249,"properties":2274},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2250,"slug":10,"properties":2251,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":2257,"manageAffiliations":2258,"indexDatabases":2259,"url":107,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":2252,"issn":2253,"introduce":2254,"eissn":2255,"title":2256},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[2260,2267],{"id":87,"indexDatabase":2261,"url":102,"indexYears":24,"academicFieldIds":2266,"indexDatabaseRanking":24},{"id":89,"createTime":90,"updateTime":91,"relativeEntities":2262,"label":2263,"description":2264,"key":98,"publicationTags":2265,"standard":24},[],{"EN":94,"VI":94},{"VI":96,"EN":97},[100,101],[104,105,106],{"id":67,"indexDatabase":2268,"url":80,"indexYears":81,"academicFieldIds":2273,"indexDatabaseRanking":85},{"id":69,"createTime":70,"updateTime":71,"relativeEntities":2269,"label":2270,"description":2271,"key":77,"publicationTags":2272,"standard":24},[],{"EN":74,"VI":74},{"EN":74,"VI":76},[79],[83,84],{"volume":2275,"pages":2277,"issue":2279},{"VOID":2276},"1",{"VOID":2278},"347-357",{"VOID":2280},"4",143,{"total":2281,"publishYear":24,"statisticByYear":2283},{"2013":224,"2014":224,"2015":224,"2016":224,"2018":224},"1987-06-01",1987,[2287,2290,2293,2296,2299,2302,2305,2308,2311,2314,2317,2320,2323,2326,2329,2332,2335,2338,2341,2344,2347,2350,2353,2356,2359,2362,2365,2368,2371,2374,2378,2381,2384,2387,2390,2393,2396,2399,2402,2405,2408,2411,2414,2417,2420,2423,2426,2429,2432],{"id":24,"text":2288,"url":24,"identifiers":2289},"10.1016\u002F0092-8674(82)90159-3",{"doi":2288},{"id":24,"text":2291,"url":24,"identifiers":2292},"10.1038\u002F306274a0",{"doi":2291},{"id":24,"text":2294,"url":24,"identifiers":2295},"10.1016\u002F0092-8674(77)90272-0",{"doi":2294},{"id":24,"text":2297,"url":24,"identifiers":2298},"10.1016\u002F0092-8674(79)90333-7",{"doi":2297},{"id":24,"text":2300,"url":24,"identifiers":2301},"10.1038\u002F312608a0",{"doi":2300},{"id":24,"text":2303,"url":24,"identifiers":2304},"10.1073\u002Fpnas.82.21.7299",{"doi":2303},{"id":24,"text":2306,"url":24,"identifiers":2307},"10.1093\u002Fnar\u002F9.15.3719",{"doi":2306},{"id":24,"text":2309,"url":24,"identifiers":2310},"10.1038\u002F296262a0",{"doi":2309},{"id":24,"text":2312,"url":24,"identifiers":2313},"10.1073\u002Fpnas.77.11.6511",{"doi":2312},{"id":24,"text":2315,"url":24,"identifiers":2316},"1982, Recombinant genomes which express chloramphenicol acetyl transferase in mammalian cells., Mol. Cell. Biol., 2, 1044",{},{"id":24,"text":2318,"url":24,"identifiers":2319},"10.1016\u002F0042-6822(73)90341-3",{"doi":2318},{"id":24,"text":2321,"url":24,"identifiers":2322},"10.1016\u002F0092-8674(83)90216-7",{"doi":2321},{"id":24,"text":2324,"url":24,"identifiers":2325},"1982, Regulation in vivo of a mammalian gene: Cadmium induction of a mouse metallothionein gene in SV40 vectors., J. Mol. Appl. Genet., 1, 273",{},{"id":24,"text":2327,"url":24,"identifiers":2328},"10.1016\u002F0092-8674(83)90535-4",{"doi":2327},{"id":24,"text":2330,"url":24,"identifiers":2331},"10.1073\u002Fpnas.82.19.6455",{"doi":2330},{"id":24,"text":2333,"url":24,"identifiers":2334},"1984, Common control of the heat shock gene and early adenovirus genes: Evidence for a cellular EIa-like activity., Mol. Cell. Biol., 4, 867",{},{"id":24,"text":2336,"url":24,"identifiers":2337},"10.1073\u002Fpnas.76.8.3665",{"doi":2336},{"id":24,"text":2339,"url":24,"identifiers":2340},"1983, Transcriptional activation and subsequent control of the human heat shock gene during adenovirus infection., Mol. Cell. Biol., 3, 2058",{},{"id":24,"text":2342,"url":24,"identifiers":2343},"1985, Analysis of an activatable promoter: Sequences in the simian virus 40 late promoter required for T antigen mediated transactivation., Mol. Cell. Biol., 5, 1859",{},{"id":24,"text":2345,"url":24,"identifiers":2346},"1983, Simian virus 40 and polyomavirus induce synthesis of heat shock proteins in mammalian cells., Mol. Cell. Biol., 3, 1",{},{"id":24,"text":2348,"url":24,"identifiers":2349},"10.1038\u002F312280a0",{"doi":2348},{"id":24,"text":2351,"url":24,"identifiers":2352},"1984, Regulation of transcription of the adenovirus EII promoter by Ela gene products: Absence of sequence specificity., Mol. Cell. Biol., 4, 1970",{},{"id":24,"text":2354,"url":24,"identifiers":2355},"10.1016\u002F0092-8674(85)90049-2",{"doi":2354},{"id":24,"text":2357,"url":24,"identifiers":2358},"1986, Binding of polyomavirus large T antigen to the human hsp70 promoter is not required for trans-activation., Mol. Cell. Biol., 6, 3180",{},{"id":24,"text":2360,"url":24,"identifiers":2361},"10.1126\u002Fscience.2935935",{"doi":2360},{"id":24,"text":2363,"url":24,"identifiers":2364},"10.1038\u002F304596a0",{"doi":2363},{"id":24,"text":2366,"url":24,"identifiers":2367},"10.1016\u002F0092-8674(86)90704-X",{"doi":2366},{"id":24,"text":2369,"url":24,"identifiers":2370},"1986, Stimulation of the adenovirus E2 promoter by simian virus 40 T antigen or EIa occurs by different mechanisms., Mol. Cell. Biol., 6, 2020",{},{"id":24,"text":2372,"url":24,"identifiers":2373},"Maniatis, T., E. Fritsch, and J. Sambrook. 1982. Molecular cloning: A laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.",{},{"id":24,"text":2375,"url":24,"identifiers":2376},"1982, Regulation of heat shock genes: A DNA sequence upstream of Drosophila hsp70 genes is essential for their induction in monkey cells., EMBO J., 1, 1279, 10.1002\u002Fj.1460-2075.1982.tb00025.x",{"doi":2377},"10.1002\u002Fj.1460-2075.1982.tb00025.x",{"id":24,"text":2379,"url":24,"identifiers":2380},"10.1016\u002F0092-8674(82)90453-6",{"doi":2379},{"id":24,"text":2382,"url":24,"identifiers":2383},"10.1016\u002F0092-8674(82)90249-5",{"doi":2382},{"id":24,"text":2385,"url":24,"identifiers":2386},"10.1016\u002F0168-9525(85)90012-5",{"doi":2385},{"id":24,"text":2388,"url":24,"identifiers":2389},"10.1016\u002F0092-8674(86)90693-8",{"doi":2388},{"id":24,"text":2391,"url":24,"identifiers":2392},"10.1126\u002Fscience.6463648",{"doi":2391},{"id":24,"text":2394,"url":24,"identifiers":2395},"10.1038\u002F306803a0",{"doi":2394},{"id":24,"text":2397,"url":24,"identifiers":2398},"10.1073\u002Fpnas.77.10.5706",{"doi":2397},{"id":24,"text":2400,"url":24,"identifiers":2401},"10.1038\u002F304602a0",{"doi":2400},{"id":24,"text":2403,"url":24,"identifiers":2404},"10.1073\u002Fpnas.84.1.170",{"doi":2403},{"id":24,"text":2406,"url":24,"identifiers":2407},"1986, Human growth hormone as a receptor gene in regulation studies using transient growth expression., Mol. Cell. Biol., 6, 3173",{},{"id":24,"text":2409,"url":24,"identifiers":2410},"10.1016\u002F0092-8674(82)90137-4",{"doi":2409},{"id":24,"text":2412,"url":24,"identifiers":2413},"10.1073\u002Fpnas.83.16.5914",{"doi":2412},{"id":24,"text":2415,"url":24,"identifiers":2416},"10.1126\u002Fscience.325648",{"doi":2415},{"id":24,"text":2418,"url":24,"identifiers":2419},"10.1016\u002F0092-8674(85)90219-3",{"doi":2418},{"id":24,"text":2421,"url":24,"identifiers":2422},"10.1073\u002Fpnas.82.18.6070",{"doi":2421},{"id":24,"text":2424,"url":24,"identifiers":2425},"1985, Structure and expression of the human gene encoding major heat shock protein hsp70., Mol. Cell. Biol., 5, 330",{},{"id":24,"text":2427,"url":24,"identifiers":2428},"10.1073\u002Fpnas.83.3.629",{"doi":2427},{"id":24,"text":2430,"url":24,"identifiers":2431},"1986, The EIA 13S product of adenovirus 5 activates transcription of the cellular human hsp70 gene., Mol. Cell. 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