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other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. 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The main objectives of the journal include: providing an intellectual platform for Vietnamese and international scholars; promoting interdisciplinary studies in social sciences and humanities; becoming the leading journal in social sciences and humanities in Vietnam; being indexed by worldwide databases and having academic recognition internationally in the near future.\\nThe journal is currently indexed by Google Scholar, WorldCat, Open Archives, Cosmos Impact Factor, Advanced Sciences Index, Scientific Indexing Services, CrossRef, EBSCO Information Services and Vietnam National University’s digital archive.\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Journal of Social Sciences and Humanities-Vietnam\"},{\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"ISSN 2354-1172, email: tapchikhxhnv@gmail.com, tckhxhnv@vnu.edu.vn\"},{\"insert\":\"\\n\"}]}","{\"ops\":[{\"insert\":\"Được thành lập ngày 31\u002F8\u002F2015 (giấy phép hoạt động số 155\u002FGP-BVHTT ngày 11 tháng 5 năm 2015 của Bộ Thông tin và Truyền thông, mã số tiêu chuẩn quốc tế ISSN 2354-1172), Tạp chí Khoa học Xã hội và Nhân văn (Journal of Social Sciences and Humanities) là ấn phẩm khoa học chính thức, duy nhất của Trường Đại học Khoa học Xã hội và Nhân văn, ĐHQG Hà Nội, phát triển và kế thừa Chuyên san Khoa học Xã hội và Nhân văn, Tạp chí Khoa học, ĐHQG Hà Nội.\\nTạp chí xuất bản định kỳ (04 số tiếng Việt\u002Fnăm và 02 số tiếng Anh\u002Fnăm), có nhiệm vụ \"},{\"attributes\":{\"italic\":true},\"insert\":\"công bố, giới thiệu các công trình nghiên cứu khoa học khoa học xã hội và nhân văn của các tác giả là các nhà khoa học trong và ngoài nước, phục vụ giảng dạy, học tập và nghiên cứu khoa học\"},{\"insert\":\". 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History\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Science and Technology Development Journal\"},{\"insert\":\" (STDJ) (ISSN 2734-9446), Vietnam National University - Ho Chi Minh City (VNU-HCM) was established in 1997. And the first issue was published in January 1998 with ISSN 1859-0128. Since then, STDJ has become the most important scientific forum of scientists from VNU-HCM as well as other universities. The magazine has undergone 20 years of development and has become a bridge for scientific exchanges, as well as enriching reference materials for the faculty, doctoral students, students of VNU-HCM in particular and other universities, institutes...\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Science and Technology Development Journal - Health Sciences (STDJ-HS) is a subjournal of Science and Technology Development Journal since 2020.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\" \"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"2. 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(WHO), Cancer, Fact sheet#297, updated February 2014.\nJ. L. Biedler and H. Riehm, “Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross resistance, radioaugraphic, and cytogenetic studies,” Cancer Res., vol. 30 (4), pp. 1174-1184, 1970.\nM. Lehnert, “Clinical multidrug resistance in cancer: a multifactorial problem,” Eur. J. Cancer, vol. 32A, pp. 912-920, 1996.\nS. M. Simon and M. Schindler, “Cell biological mechanisms of multidrug resistance in tumors,” Proc. Natl. Acad. Sci. USA., vol. 91, pp. 3497-3504, 1994.\nD. Longley and P. Johnston, “Molecular mechanisms of drug resistance,” J. Pathol., vol. 205 (2), pp. 275-292, 2005.\nR. Jaiswal, J. Gong, S. Sambasivam, V. Combes, J. M. Mathys, R. Davey, et al, “Microparticle-associated nucleic acids mediate trait dominance in cancer,” The FASEB J., vol. 26 (1), pp. 420-429, 2012.\nL. M. Breuninger, S. Paul, K. Gaughan, T. Miki, A. Chan, S. A. Aaronson, et al, “Expression of multidrug resistance-associated protein in NIH\u002F3T3 cells confer multidrug resistance associated with increased drug efflux and altered intracellular drug distribution,” Cancer Res., vol. 55 (22), pp. 5342-5347, 1995.\nV. Drinberg, R. Bitcover, W. Rajchenbach, and D. Peer, “Modulating cancer multidrug resistance by sertraline in combination with a nanomedicine,” Cancer Letters, vol. 354, pp. 290-298, 2014.\nM. Bebawy, M.B. Morris, and B. D. Roufogalis, “A continuous fluorescence assay for the study of p-gp mediated drug efflux using inside-out membrane vesicles,” Anal. Biochem., vol. 268, pp. 270-277, 1999.\nB. Tan, D. Piwnica-Worms, and L. Ratner, “Multidrug resistance transporters and modulation,” Curr. Opin. Oncol., vol. 12, pp. 450-458, 2002.\nM. M. Gottesman, T. Fojo, and S. E. Bates, “Multidrug resistance in cancer: role of ATP-dependent transporters,” Nat. Rev. Cancer., vol. 2 (1), pp. 48-58, 2002.\nR. Callaghan, E. Crowley, S. Potter, and I. 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Recently, microparticles (MP) were found to play a major role in mediating the resistance to antineoplastic agents. Microparticles can confer MDR phenotype to cancer cells though 3 complimentary pathways: 1) Intercellular transfer of P-gp and MRP1; 2) Intercellular transfer of regulatory nucleic acids that ensure acquisition of MDR phenotype; and 3) Internal sequestration of anticancer drugs to reduce the amount of free active drug. Compounds that inhibit MP formation that are currently under investigation include calpain inhibitors, RhoA inhibitors, ROCK inhibitors, calcium channel blockers, pantethine, glutaminase inhibitors, some anti-platelet drugs and some lipid-lowering agents. This area of research requires further development to select, improve and test those compounds that show the most promise in providing safe and effective treatment against MDR.",{"EN":690},"Overcoming cancer multidrug resistance through inhibition of microparticles",{"VOID":692},"10.7603\u002Fs40782-014-0023-8","PUBLICATION","2025-01-04T02:29:45.515+00:00","Auto Verify","http:\u002F\u002Fwww.globalsciencejournals.com\u002Farticle\u002F10.7603\u002Fs40782-014-0023-8",[698,714,729],{"id":699,"sortIndex":115,"researcher":26,"roles":700,"affiliations":702,"properties":711},"fb32c962-4148-4e35-8f31-9e26d00dccaa",[701],"AUTHOR",[703],{"id":26,"sortIndex":36,"affiliation":704,"properties":26},{"id":705,"createTime":706,"updateTime":706,"relativeEntities":707,"slug":26,"properties":708,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"7d89d5e0-e0ee-422b-8e3c-80dd91b11ea7","2023-12-18T08:23:00.739+00:00",[],{"title":709},{"VI":710},"Touro College of Pharmacy, New York, United States of America",{"title":712},{"VI":713},"Rivka Winzelberg",{"id":715,"sortIndex":114,"researcher":26,"roles":716,"affiliations":717,"properties":726},"2b9a9539-3bb2-4355-9a79-f6b1228fe842",[701],[718],{"id":26,"sortIndex":36,"affiliation":719,"properties":26},{"id":720,"createTime":721,"updateTime":721,"relativeEntities":722,"slug":26,"properties":723,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"1b36fde0-559f-4afb-866a-8b1b0c28ce3c","2023-12-18T08:22:43.251+00:00",[],{"title":724},{"VI":725},"Department of Biomedical and Pharmaceutical Sciences, Touro College of Pharmacy, New York, United States of America",{"title":727},{"VI":728},"Mariana Babayeva",{"id":730,"sortIndex":36,"researcher":26,"roles":731,"affiliations":732,"properties":738},"4bcf6c0a-8d05-4d4a-97cd-cf49f738b55a",[701],[733],{"id":26,"sortIndex":36,"affiliation":734,"properties":26},{"id":705,"createTime":706,"updateTime":706,"relativeEntities":735,"slug":26,"properties":736,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":737},{"VI":710},{"title":739},{"VI":740},"Sora Vysotski","ARTICLE",{"url":696,"publisher":743,"properties":752},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":744,"slug":663,"properties":745,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":749,"manageAffiliations":750,"indexDatabases":751,"url":26,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":746,"title":747,"url":748},{"VOID":666},{"EN":668},{"VOID":670},[],[],[],{"volume":753,"pages":755},{"VOID":754},"1",{"VOID":756},"1-9","2016-04-07",2016,false,{"id":761,"createTime":762,"updateTime":763,"relativeEntities":764,"slug":765,"properties":766,"entityType":693,"verifyStatus":25,"verifyTime":763,"verifyNote":695,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"primaryUrl":775,"fullTextUrl":26,"authors":776,"publicationType":741,"publisherRelationship":804,"citationCount":26,"citationInfo":26,"publishDate":818,"publishYear":819,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":26,"isForceReanalyzing":759},"f216c4aa-aee4-406d-99a1-5bb1d525680f","2024-01-17T04:41:17.525+00:00","2025-01-11T19:06:22.878+00:00",[],"Hemodynamic-Assessment-to-Evaluate-Pulmonary-Hypertension-in-Patients-with-Aortic-Stenosis",{"references":767,"abstract":769,"title":771,"doi":773},{"VOID":768},"Silver K, Aurigemma G, Krendel S, Barry N, Ockene I, Alpert J., Pulmonary artery hypertension in severe aortic stenosis: incidence and mechanism. Am Heart J 1993;125:146–50.\nNikhil Kapoor, Padmini Varadarajan, and Ramdas G. Pai, Echocardiographic predictors of pulmonary hypertension in patients with severe aortic stenosis. European Journal of Echocardiography (2008) 9, 31–33\nConnolly HM, Ballman KV, Roger VL, Tajik AJ, Aosrtic stenosis: no more hemodynamic cardiac catherization (letter). Mayo Clin Proc 2001;76:961\nC.M. Schannwell, S. Steiner, B-E. Strauer, Diagnostics in Pulmonary Hypertension, Journal of Physiology and Pharmacology 2008, 58, Suppl 5, 591–602\nHomma A, Anzueto A, Peters JI et al Pulmonary artery systolic pressures estimated by echocardiogram vs cardiac catherization in patients awaiting lung transplantation J Heart Lung Transplant, 2001; 20: 833–39\nTorbicki A, Skwarski K, Hawrylkiewics I et al Attempts at measuring pulmonary arterial pressure by means of Doppler echocardiography in patients with chronic lung disease. Eur Respir J, 1989; 2: 856–60\nJoseph F. Malouf, Maurice Enriquez-Sarano, Patricia Pellikka et al. Severe Pulmonary Hypertension in Patients With Severe Aortic Valve Stenosis : Clinical Profile and Prognostic Implications Journal of the American College of Cardiology, 2002 . Vol.40, No.4; 789–95\nG.P. Tracy, M.S. Proctor and C.S. Hizny Reversibility of pulmonary artery hypertension in aortic stenosis after aortic valve replacement. Ann Thorac Surg, 1990, Vol.50, 89–93\nPompilio Faggiono, Francesco Antionin-Canterin, Falvio Ribichini et al Pulmonary Artery Hypertension in Adult Patients With Symptomatic Valvular Aortic Stenosis Am J Cardiol 2000;85:204–208\nLeborgne L.;Tribouilloy C.;Otmani A;Peltier M.;Rey J.et al Comparative value of Doppler echocardiography and cardiac catherization in the decision to operate on patients with aortic stenosis International Journal of Cardiology, 1998, Vol. 65, No.2, 163–168\nArcasoy SM, Christie JD, Ferrari VA et al Echocardiographic assessment of pulmonary hypertension in patients with advanced lung disease Clinical risk factors for primary graft failure following lung transplantation. Am J Respir Crit Care Med, 2003, 167:735–40\nKaren L. Swanson, James P. Utz, Michael J. Krowka et al Doppler echocardiography – right heart catherization relationships in patients with idiopathic pulmonary fibrosis and suspected pulmonary hypertension Med Sci Monit, 2008; 14(4): CR177–182\nLW Johnson, MB Hapanowicz, C Buonanno, MA Browser et al Pulmonary hypertension in isolated aortic stenosis. Hemodynamic correlations and follow-up The Journal of Thoracic and Cardiovascular Surgery 1988, Vol 95, 603–607\nRobert S. Finkelhor, Moayyed Moallem, and Robert C. Bahler Characteristc and Impact of Obesity on the Outpatient Echocardiographic Laboratory J Cardiol 2006;97 :1082–1084)\nWylie BJ, Epps KC, Gaddipati S, Waksmonski CA Correlation of transthoracic echocardiography and right heart catherization in pregnancy J Perinat Med. 2007; 35(6):497–502\nVivien M. HSU, Abel E. Moreyra, Alan C. Wilson et al. Assessment of Pulmonary Arterial Hypertension in Patients with Systemic Sclerosis: Comparison of Noninvasive Testing with Reults of Right-Heart Catherization J Rheumatol 2008;35:458–65\nBiner S, Rafique AM, Goykhman P, Morrissey RP, Naghi J, Siegel RJ., Prognostic Value of E\u002FE’ Ratio in Patients With Unoperated Severe Aortic Stenosis JACC Cardiovasc Imaging. 2010 Sep;3(9):899–90\nMcQuillan BM, Picard MH, Leavitt M, Weyman AE., Clinical Correlates and Referenc Intervals for Pulmonary Artery Systolic Pressure Among Echocardiographically Normal Subjects, Circulation. 2001 Dec 4;104 (23):2797–802",{"EN":770},"Severe pulmonary hypertension is prevalent as high as 29% in patient with severe aortic stenosis and significantly increases morbidity and mortality in these patients (1). Early Aortic Valve Replacement (AVR) for this high-risk subset of patients with Aortic Stenosis (AS) has been recommended (1).The etiology of Pulmonary Hypertension (PHT) in severe AS remains unclear however left ventricular (LV) dysfunction may be of one important etiology (2).",{"EN":772},"Hemodynamic Assessment to Evaluate Pulmonary Hypertension in Patients with Aortic Stenosis",{"VOID":774},"10.7603\u002Fs40782-014-0001-1","http:\u002F\u002Fwww.globalsciencejournals.com\u002Farticle\u002F10.7603\u002Fs40782-014-0001-1",[777,792],{"id":778,"sortIndex":36,"researcher":26,"roles":779,"affiliations":780,"properties":789},"d8f16d4b-868a-46f5-87d9-cd4dc8d45546",[701],[781],{"id":26,"sortIndex":36,"affiliation":782,"properties":26},{"id":783,"createTime":784,"updateTime":784,"relativeEntities":785,"slug":26,"properties":786,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"f3d043ac-2b90-46ef-a05e-c6a7cbad2dd2","2024-01-17T04:41:17.542+00:00",[],{"title":787},{"VI":788},"Cardiology Fellow, University of Virginia, Charlottesville, USA",{"title":790},{"VI":791},"Yasir Akhtar",{"id":793,"sortIndex":115,"researcher":26,"roles":794,"affiliations":795,"properties":801},"eb3fd7ba-19a0-4cd7-b03c-0f2321d4600e",[701],[796],{"id":26,"sortIndex":36,"affiliation":797,"properties":26},{"id":783,"createTime":784,"updateTime":784,"relativeEntities":798,"slug":26,"properties":799,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":800},{"VI":788},{"title":802},{"VI":803},"Elisabeth von der Lohe",{"url":775,"publisher":805,"properties":814},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":806,"slug":663,"properties":807,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":811,"manageAffiliations":812,"indexDatabases":813,"url":26,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":808,"title":809,"url":810},{"VOID":666},{"EN":668},{"VOID":670},[],[],[],{"volume":815,"pages":816},{"VOID":754},{"VOID":817},"1-11","2014-06-05",2014,{"id":821,"createTime":822,"updateTime":823,"relativeEntities":824,"slug":825,"properties":826,"entityType":693,"verifyStatus":25,"verifyTime":823,"verifyNote":695,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"primaryUrl":835,"fullTextUrl":836,"authors":837,"publicationType":741,"publisherRelationship":883,"citationCount":26,"citationInfo":26,"publishDate":898,"publishYear":819,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":26,"isForceReanalyzing":759},"876e5d05-5b36-41d1-b450-6ab9c32e4c2f","2024-01-29T09:45:57.375+00:00","2025-02-25T10:20:52.129+00:00",[],"Isolated-Non-Compacted-Right-Ventricular-Myocardium-with-Severe-Pulmonary-Hypertension",{"references":827,"abstract":829,"title":831,"doi":833},{"VOID":828},"Maheshwari, Monika, RK Gokroo and SK Kaushik. CASE REPORT: Isolated Non-Compacted Right Ventricular Myocardium. JAPI: May 2012, VOL. 60\ncitation_journal_title=Circulation; citation_title=Noncompaction of the Ventricular Myocardium; citation_author=Brian C. Weiford, Vijay D. Subbarao, Kevin M. Mulhern; citation_volume=109; citation_publication_date=2004; citation_pages=2965-2971; citation_doi=10.1161\u002F01.CIR.0000132478.60674.D0; citation_id=CR2\ncitation_journal_title=Circulation; citation_title=Report of the 1995 World Health Organization\u002FInternational Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies; citation_author=P Richardson, W Mckenna, M Bristow, B Maisch, B Mautner, J O†²Connell; citation_volume=93; citation_publication_date=1996; citation_pages=841-842; citation_doi=10.1161\u002F01.CIR.93.5.841; citation_id=CR3\ncitation_journal_title=European Journal of Echocardiography; citation_title=An unusual case of isolated non-compacted right ventricular myocardium; citation_author=null Nilesh, S. Mullasari; citation_volume=9; citation_publication_date=2008; citation_pages=424-425; citation_doi=10.1093\u002Fejechocard\u002Fjen016; citation_id=CR4\ncitation_journal_title=European Heart Journal; citation_title=Bauersfeld. Myocardial ischaemia in children with isolated ventricular non-compaction; citation_author=G. Junga, S. Kneifel, A. Smekal; citation_volume=20; citation_publication_date=1999; citation_pages=910-916; citation_doi=10.1053\u002Feuhj.1998.1398; citation_id=CR5\ncitation_journal_title=Cardiovascular Ultrasound; citation_title=Non-compacted cardiomyopathy: clinical-echocardiographic study; citation_author=Nilda Espinola-Zavaleta, M Elena Soto, Luis Muñóz Castellanos, Silvio Játiva-Chávez, Keirns Candace; citation_volume=4; citation_publication_date=2006; citation_pages=35; citation_doi=10.1186\u002F1476-7120-4-35; citation_id=CR6\ncitation_journal_title=Pediatr Cardiol; citation_title=Noncompaction of the Right Ventricle; citation_author=; citation_volume=31; citation_publication_date=2010; citation_pages=576-578; citation_doi=10.1007\u002Fs00246-010-9652-6; citation_id=CR7\ncitation_journal_title=Heart; citation_title=Echocardiographic and path anatomical characteristics of isolated left ventricular non-compaction: a step towards classification as a distinct cardiomyopathy; citation_author=R Jenni, E Oechslin, J Schneider, C Attenhofer Jost, P A Kaufmann; citation_volume=86; citation_publication_date=2001; citation_pages=666-671; citation_doi=10.1136\u002Fheart.86.6.666; citation_id=CR8\ncitation_journal_title=HEART VIEWS; citation_title=Isolated Left Ventricular Noncompaction: Case Report and Review of the Literature; citation_author=Awad Alqahtani, Alnabti Abdulrahman; citation_volume=10; citation_publication_date=2009; citation_pages=30-37; citation_id=CR9\ncitation_journal_title=European Journal of Echocardiography; citation_title=Left ventricular non-compaction: is it really isolated?; citation_author=Stefano Muzzarelli, Peter Buser, Alain Bernheim, Linka. Andre; citation_volume=9; citation_publication_date=2008; citation_pages=321-322; citation_doi=10.1093\u002Fejechocard\u002Fjen065; citation_id=CR10\nOdiete, Oghenerukevwe, Ramanna Nagendra, Mark A. Lawson, and Henry Okafor. Biventricular Noncompaction Cardiomyopathy in a Patient Presenting with New Onset Seizure: Case Report. Hindawi Publishing Corporation: Case Reports in Cardiology: Volume 2012.\nOechslin, Erwin N., MD, Christine H. AttenhoferJost, MD, Jerry R. Rojas, MD, Philipp A. Kaufmann, MD, and Rolf Jenni, MD, MSEE. Long-Term Follow-up of 34 Adults With Isolated Left Ventricular Noncompaction: A Distinct Cardiomyopathy With Poor Prognosis. Switzerland: Elsevier Science Inc. Journal of the American College of Cardiology. Vol. 36, No. 2, 2000\ncitation_journal_title=Circulation; citation_title=AHA Scientific Statement. Contemporary Definition and Classification of the Cardiomyopathies; citation_author=BJ Maron, JA Towbin, G Thiene, C Antzelevich, D Corrado, D Arnett, AJ Moss, CE Seidman, JB Young; citation_volume=113; citation_publication_date=2006; citation_pages=1807-1816; citation_doi=10.1161\u002FCIRCULATIONAHA.106.174287; citation_id=CR13\ncitation_journal_title=Eur Heart J; citation_title=Cardiomyopathies: Is it time for a molecular classification?; citation_author=G Thiene, D Corrado, C Basso; citation_volume=25; citation_publication_date=2004; citation_pages=1772-1775; citation_doi=10.1016\u002Fj.ehj.2004.07.026; citation_id=CR14\ncitation_journal_title=Chin Med J; citation_title=A rare case of isolated non-compaction right ventricular myocardium; citation_author=Zhang Xiao-Juan, Guang Zhi; citation_volume=122; citation_issue=14; citation_publication_date=2009; citation_pages=1718-1720; citation_id=CR15\ncitation_journal_title=International Journal of Cardiology; citation_title=An isolated right ventricular hypertrabeculation and dyskinesia in an elderly man: A possible diagnosis of isolated right ventricular noncompaction?; citation_author=Ze Zhou Song; citation_volume=148; citation_issue=1; citation_publication_date=2011; citation_pages=e3-e6; citation_doi=10.1016\u002Fj.ijcard.2009.01.054; citation_id=CR16",{"EN":830},"There have been only at least seven cases of isolated right ventricular non-compaction reported in literature, hence, there are no definite criteria for diagnosis and recommendations for management of these patients. The reported clinical manifestations include heart failure, arrhythmias and cardioembolic events. Left ventricular and biventricular non-compaction are likewise rare but more common than isolated right ventricular non-compaction. Pulmonary hypertension is associated with biventricular non-compaction more commonly but not with isolated right ventricular non-compaction. University of Santo Tomas Hospital We report a case of a 25 year old female who presented with progressive dyspnea for one year accompanied by easy fatigability. She denied chest pain, palpitations, pedal edema, paroxysmal nocturnal dyspnea and orthopnea. She had a brother who died at a young age reportedly due to a cardiac illness which was not fully worked-up. Her 2D echocardiogram showed excessive prominent trabeculations and deep inter-trabecular recesses in the right ventricular wall with depressed right ventricular systolic function by tricuspid annular plane systolic excursion and fractional area change. Color Doppler studies also showed severe tricuspid regurgitation, pulmonic regurgitation and severe pulmonary hypertension. Secondary causes of pulmonary hypertension like connective tissue diseases, left heart disease, chronic thrombotic\u002Fembolic disease, anomalous cardiac and pulmonary shunts and lung disease were excluded. She was given diltiazem, sildenafil, digoxin, warfarin overlapped with subcutaneous enoxaparin and oxygen supplementation which provided symptomatic relief.",{"EN":832},"Isolated Non-Compacted Right Ventricular Myocardium with Severe Pulmonary Hypertension",{"VOID":834},"10.7603\u002Fs40782-014-0002-0","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.7603\u002Fs40782-014-0002-0","https:\u002F\u002Flink.springer.com\u002Fcontent\u002Fpdf\u002F10.7603\u002Fs40782-014-0002-0.pdf",[838,853,868],{"id":839,"sortIndex":114,"researcher":26,"roles":840,"affiliations":841,"properties":850},"7d991cec-ddbb-4e62-ac53-521d6884926a",[701],[842],{"id":26,"sortIndex":36,"affiliation":843,"properties":26},{"id":844,"createTime":845,"updateTime":845,"relativeEntities":846,"slug":26,"properties":847,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"649d1ebe-0667-4b50-8f03-7a7b658d852c","2024-01-29T09:45:57.432+00:00",[],{"title":848},{"VI":849},"Department of Medicine and the Medical Director, University of Santo Tomas Hospital, Metro Manila, Philippines",{"title":851},{"VI":852},"Caguioa, Eduardo Vicente",{"id":854,"sortIndex":36,"researcher":26,"roles":855,"affiliations":856,"properties":865},"0a0a455e-2980-44d0-8868-df11b876cda5",[701],[857],{"id":26,"sortIndex":36,"affiliation":858,"properties":26},{"id":859,"createTime":860,"updateTime":860,"relativeEntities":861,"slug":26,"properties":862,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"fd80d883-3d55-490b-8ad2-09dc6f21d58c","2024-01-29T09:45:57.406+00:00",[],{"title":863},{"VI":864},"Department of Medicine, University of Santo Tomas Hospital, Metro Manila, Philippines",{"title":866},{"VI":867},"Vicera, Jennifer Jeanne B.",{"id":869,"sortIndex":115,"researcher":26,"roles":870,"affiliations":871,"properties":880},"19d73959-c214-4454-82b5-606065ad6035",[701],[872],{"id":26,"sortIndex":36,"affiliation":873,"properties":26},{"id":874,"createTime":875,"updateTime":875,"relativeEntities":876,"slug":26,"properties":877,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"b4c51422-ec97-4ac8-8ce8-c5190db6f082","2024-01-29T09:45:57.419+00:00",[],{"title":878},{"VI":879},"Department of Medicine and the Head of the Catheterization Laboratory, University of Santo Tomas Hospital, Metro Manila, Philippines",{"title":881},{"VI":882},"Tan-De Guzman, Wilson",{"url":835,"publisher":884,"properties":893},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":885,"slug":663,"properties":886,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":890,"manageAffiliations":891,"indexDatabases":892,"url":26,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":887,"title":888,"url":889},{"VOID":666},{"EN":668},{"VOID":670},[],[],[],{"volume":894,"pages":895,"issue":897},{"VOID":754},{"VOID":896},"1-8",{"VOID":754},"2014-05-01",{"id":900,"createTime":901,"updateTime":902,"relativeEntities":903,"slug":904,"properties":905,"entityType":693,"verifyStatus":25,"verifyTime":902,"verifyNote":695,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"primaryUrl":914,"fullTextUrl":26,"authors":915,"publicationType":741,"publisherRelationship":942,"citationCount":26,"citationInfo":26,"publishDate":956,"publishYear":819,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":26,"isForceReanalyzing":759},"78e10fe1-eb52-47ee-8379-72431b43b07a","2023-12-31T04:41:56.562+00:00","2024-10-11T07:30:37.357+00:00",[],"Use-of-Mass-Spectrometric-Approaches-to-Tackle-Challenges-in-Drug-Discovery-The-Beta-Amyloid-Paradigm",{"references":906,"abstract":908,"title":910,"doi":912},{"VOID":907},"E. von Strauss, M. Viitanen, D. De Ronchi, B. Winblad, and L. Fratiglioni, “Aging and the occurrence of dementia: Findings from a population-based cohort with a large sample of nonagenarians,” Arch Neurol 1999, 56, 587–592.\nWorld Alzheimer’s Report 2013.\nKarolinska Institute Report on Dementia 2010.\nC. Behl, “Alzheimer’s disease and oxidative stress: implications for novel therapeutic approaches,” Prog. Neurobiol. 1999, 57, 301–323.\nC.A. Ross and M.A. Poirier, “Protein aggregation and neurodegenerative disease,” Nat. Med. 2004, 10 (Suppl), S10–S17.\nJ.A. Hardy and G.A. Higgins, “Alzheimer’s disease: the amyloid cascade hypothesis,” Science 1992, 256, 184–185.\nJ. Hardy, “Has the amyloid cascade hypothesis for Alzheimer’s disease been proved?”, Curr. Alzheimer Res. 2006, 3, 71–73.\nW. Retz, W. Gsell, G. Munch, M. Rosler and P. Riederer, “Free radicals in Alzheimer’s disease,” J. Neural Transm. 1998, 54, 221–236.\nG. Aliev, M.A. Smith, D. Seyidov, M.L. Neal, B.T. Lamb, A. Nunomura, E.K. Gasimov, H.V. Vinters, G. Perry, J.C. LaManna, and R.P. Friedland, “The Role of Oxidative Stress in the Pathophysiology of Cerebrovascular Lesions in Alzheimer’s Disease,” Brain Pathol. 2002, 12, 21–35.\nP.L. McGeer, M. Schulzer, and E.G. McGeer, “Arthritis and Anti-Inflammatory Agents as Possible Protective Factors for Alzheimer’s Disease: A Review of 17 Epidemiologic Studies,” Neurology 1996, 47, 425–432.\nE. Giacobini and G. Gold, “One hundred years after discovery of Alzheimer’s disease. A turning point for therapy?” J. Alzheimers Dis. 2007, 12, 37–52.\nR.E. Becker and H.H. Greig, “Increasing the success rate for Alzheimer’s disease drug discovery and development,” Expert Opin. Drug Discov. 2012, 4, 367–370.\nJ. Walter, and C. Haass, “Secretases as Targets for ß-Amyloid Lowering Drugs,” Drug Dev. Res. 2002, 56, 201– 210.\nD.M. Walsh, I. Klyubin, J.V. Fadeeva, M.J. Rowan, and D.J. Selkoe, “Amyloid- ß Oligomers: Their Production, Toxicity, and Therapeutic Inhibition,” Biochem. Soc. Trans. 2002, 30, 552–557.\nV. Chesneau, K. Verkellis, M.R. Rosner, and D.J. Selkoe, “Purified Recombinant Insulin-Degrading Enzyme Degrades Amyloid ß-Protein but Does Not Promote Its Oligomerization,” Biochem. J. 2000, 351, 509–516.\nD.K. Lahiri, M.R. Farlow, N.H. Greig, and K. Sambamurti, “Current Drug Targets for Alzheimer’s Disease Treatment,” Drug. Dev. Res. 2002, 56, 267–281.\nD.J. Selkoe, “Deciphering the Genesis and Fate of Amyloid ß –Protein Yields Novel Therapies for Alzheimer Disease,” J. Clin. Invest. 2002, 110, 1375–1381.\nP.T. Lansbury Jr., “Back to the Future: The Old-Fashioned Way to New Medications for Neurodegeneration,” Nat. Rev. Neurosci. 2004, 5, S51–S57.\nP.T. Lansbury Jr., “Following Nature’s Anti-Amyloid Strategy,” Nat. Biotechnol. 2001, 19, 112–113.\nS.T. DeKosky and K. Marek “Looking backward to move forward: Early detection of neurodegenerative disorders,” Science 2003, 302, 830–834.\nM.J.R. Howes, N.S.L. Perry, and P. Houghton, “Plants with Traditional Uses and Activities Relevant to the Management of Alzheimer’s Disease and Other Cognitive Disorders,” J. Phytother. Res. 2003, 17, 1–18.\nM.M. Essa et al. “Neuroprotective Effect of Natural Products Against Alzheimer’s Disease.” Neurochem. Res., 2012, 37, 1829–1842.\nN. Myers, R.A. Mittermeier, C.G. Mittermeier, G.A. da Fonseca, and J. Kent, “Biodiversity hotspots for conservation priorities,” Nature 2000, 403, 853–858.\nW.V. Reid, “Biodiversity hotspots,” Trends Ecol. Evol., 1998, 13, 275–280.\nK. Biemann and S.A. Martin, “Mass spectrometric determination of the amino acid sequence of peptides and proteins,” Mass Spectrom. Rev. 1987, 6, 1–76.\nJ.A. Loo, “Electrospray Ionization Mass Spectrometry: A Technology for Studying Noncovalent Macromolecular Complexes,” Int. J. Mass Spectrom. 2000, 200, 175–186.\nA. Ganguly, B.N. Pramanik, G. Chen and A. Tsarbopoulos, “Detection of Non-covalent Complexes by Electrospray Ionization Mass Spectrometry” in Applied Electrospray Mass Spectrometry, Marcel Dekker: New York, 2002; p. 361–387.\nB.N. Pramanik, P.L. Bartner, U.A. Mirza, Y.H. Liu and A.K. Ganguly, “Electrospray Ionization Mass Spectrometry for the Study of Noncovalent Complexes: an Emerging Technology,” J. Mass Spectrom. 1998, 33, 911–920.\nB. Ganem, Y.T. Li, and J.D. Henion, “Detection of Noncovalent Receptor Ligand Complexes by Mass-Spectrometry,” J. Am. Chem. Soc. 1991, 113, 6294–6296.\nA.K. Ganguly, B.N. Pramanik, A. Tsarbopoulos, T.R. Covey, E. Huang and S.A. Fuhrman, “Mass Spectrometric Detection of the Noncovalent GDP-bound Conformational State of the Human H-Ras Protein”, J. Am. Chem. Soc. 1992, 114, 6559–6560.\nS. Mathur, M. Badertscher, M. Scott and R. Zenobi, “Critical Evaluation of Mass Spectrometric Measurement of Dissociation Constants: Accuracy and Cross-validation against Surface Plasmon Resonance and Circular Dichroism for the Calmodulin-Melittin System,” Phys. Chem. Phys. 2007, 9, 6187–6198.\nA. Wortmann, M.C. Jecklin, D. Touboul, M. Badertscher and R. Zenobi, “Binding Constant Determination of High- Affinity Protein–Ligand Complexes by Electrospray Ionization Mass Spectrometry and Ligand Competition,” J. Mass Spectrom. 2008, 43, 600–608.\nB. Shasha, J. Leibowityz, “On the Oleuropein, the Bitter Principle of Olives,” J. Org. Chem. 1961, 26, 1948– 1954.\nN.S. Koulakiotis, E. Pittenauer, M. Halabalaki, A. Tsarbopoulos, G. Allmaier, “Comparison of different tandem mass spectrometric techniques (ESI-IT, ESI- and IP-MALDI-QRTOF and VMALDITOF\u002FRTOF) for the analysis of crocins and picrocrocin from the stigmas of Crocus sativus L.,” Rapid Commun. Mass Spectrom. 2012, 26, 670–678.\nF.N. Bazoti, A. Tsarbopoulos, K. Markides and J. Bergquist, “Study of the Non-Covalent Interaction between Amyloid-ß Peptide and Melatonin using Electrospray Ionization Mass Spectrometry,” J. Mass Spectrom. 2005, 40, 182–192.\nF.N. Bazoti, J. Bergquist, K. Markides and A. Tsarbopoulos, “Detection of the Non-Covalent Complex between Amyloid-ß Peptide (1-40) and Oleuropein using Electrospray Ionization Mass Spectrometry,” J. Am. Soc. Mass Spectrom. 2006, 17, 568–575.\nF.N. Bazoti, J. Bergquist, K. Markides and A. Tsarbopoulos, “Localization of the Binding Site in the Non- Covalent Interaction between Amyloid-ß Peptide (1-40) and Oleuropein Using Electrospray Ionization FTICR Mass Spectrometry,” J. Am. Soc. Mass Spectrom. 2008, 19, 1078–1085.\nN.S. Koulakiotis, D. Anagnostopoulos and A. Tsarbopoulos, “Screening of Crocus sativus L.-derived components for noncovalent interaction with amyloid-ß peptide (1-40) using Electrospray Ionization Mass Spectrometry,” unpublished results.\nD.M. Walsh, A. Lomakin, G.B. Benedek, M.N. Condron, D.B. Teplow, “Amyloid Beta-Protein Fibrillogenesis. Detection of a Protofibrillar Intermediate,” J. Biol. Chem. 1997, 272, 22364–22372.",{"EN":909},"The origin of many neurodegenerative disorders like Alzheimer’s Disease (AD) lies in protein processing failures, which leads to protein aggregation and accumulation as amyloid fibrils. Abnormal accumulation and aggregation of beta amyloid peptide (Aβ) eventually lead to the formation and cerebral deposition of amyloid plaques, the major pathological hallmark in AD. Aβ1-40 and Aβ1-42 are the predominant components of senile plaques formed in AD brain. The aggregation of Aβ is associated with neurodegeneration, loss of cognitive ability, and premature death. Understanding the aggregation mechanism and how to inhibit aggregate formation is therefore crucial. In light of the proposed link between oxidative stress, unregulated immune response and neurodegeneration, it is suggested that use of antioxidants may be beneficial for inhibiting Aβ fibrillogenesis. Therefore, endogenous and dietary antioxidants may offer a protective or even therapeutic alternative against amyloidosis. In this study, several compounds isolated from natural products are screened for the in vitro antiamyloidogenic activity. Novel electrospray ionization (ESI) mass spectrometry (MS)-based methodologies are employed to assess the noncovalent interactions between the Aβ and isolated components from natural products. The specificity and the stability of these noncovalent complexes were examined under different experimental conditions, whereas their relative binding strength was assessed. In addition, MS proteolytic mapping was employed to provide information on the noncovalent binding site of the bioactive molecule on the Aβ residues. This may shed some light into the mechanisms of AD pathology and provide insights into novel agents that can be employed towards prevention or even treatment of AD.",{"EN":911},"Use of Mass Spectrometric Approaches to Tackle Challenges in Drug Discovery: The Beta-Amyloid Paradigm",{"VOID":913},"10.7603\u002Fs40782-014-0014-9","http:\u002F\u002Fwww.globalsciencejournals.com\u002Farticle\u002F10.7603\u002Fs40782-014-0014-9",[916],{"id":917,"sortIndex":36,"researcher":26,"roles":918,"affiliations":919,"properties":939},"1ca5657e-db31-4f7e-b174-0b2048ce950b",[701],[920,929],{"id":26,"sortIndex":36,"affiliation":921,"properties":26},{"id":922,"createTime":923,"updateTime":923,"relativeEntities":924,"slug":925,"properties":926,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"50877356-4207-4096-b1d4-ac783b47f986","2024-04-15T11:51:44.207+00:00",[],"Department-of-Pharmacology-University-of-Athens-Medical-School-Athens-Greece-",{"title":927},{"EN":928},"Department of Pharmacology, University of Athens Medical School, Athens, Greece.",{"id":930,"sortIndex":115,"affiliation":931,"properties":938},"741426a2-540c-4362-b6d1-ff7179fae5af",{"id":932,"createTime":933,"updateTime":933,"relativeEntities":934,"slug":26,"properties":935,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"c11cc7e9-50d4-44a2-9dc1-27e387edbda7","2023-12-31T04:41:56.580+00:00",[],{"title":936},{"VI":937},"GAIA Research Center, The Goulandris Natural History Museum, Kifissia, Greece",{},{"title":940},{"VI":941},"Anthony Tsarbopoulos",{"url":914,"publisher":943,"properties":952},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":944,"slug":663,"properties":945,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":949,"manageAffiliations":950,"indexDatabases":951,"url":26,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":946,"title":947,"url":948},{"VOID":666},{"EN":668},{"VOID":670},[],[],[],{"volume":953,"pages":954},{"VOID":754},{"VOID":955},"1-6","2014-06-04",{"id":958,"createTime":959,"updateTime":960,"relativeEntities":961,"slug":962,"properties":963,"entityType":693,"verifyStatus":25,"verifyTime":960,"verifyNote":695,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"primaryUrl":972,"fullTextUrl":26,"authors":973,"publicationType":741,"publisherRelationship":1016,"citationCount":26,"citationInfo":26,"publishDate":1030,"publishYear":1031,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":26,"isForceReanalyzing":759},"f337a51d-733b-458f-9986-b16715937845","2024-01-19T05:27:37.285+00:00","2025-01-11T14:22:01.131+00:00",[],"Troponin-Mutation-Caused-Diastolic-Dysfunction-and-Experimental-Treatment-in-Transgenic-Mice-with-Cardiomyopathy",{"references":964,"abstract":966,"title":968,"doi":970},{"VOID":965},"J. Wynne, “Restrictive cardiomyopathy,” Curr Treat Options Cardiovasc Med, vol.2, pp.431–438, 2000.\nX.P. Huang, Y. Pi, K. Lee, A. Henkel, R. Gregg, P. Powers, J. Walker, “Cardiac troponin I gene knockout, a mouse model of myocardial troponin I deficiency,’ Circ Res, vol. 84, pp1–8, 1999.\nJ. Du, “C. Zhang, J. Liu, C. Sidky, X.P. Huang, “A point mutation (R192H) in the C-terminus of human cardaic troponin I causes diastolic dysfunction in transgenic mice,” Arch Biochem Biophys, vol. 456, pp.143–150, 2006.\nP. Jean-Charles, C. Nan, L. Zhang, J. Tian, X.P. Huang, “Cardiac troponin mutations: Diastolic dysfunction and therapeutic options,” in Troponin, J.-P. Jin Eds. Nova Biomedical, 2014, pp. 259–281.\nJ. Mogensen, T. Hubo, M. Duque, W. Uribe, A. Shaw, R. Murphy, J.R. Gimeno, P. Elliott, W.J. McKenna, “Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations,” J Clin Invest, vol.111, pp.209–216, 2003.\nF. Gambarin, C. Ho, C. Semsarian, M. Baldi, M. Will, K. Baldini, F. Torricelli, L. Teates, F. Cecchi, M. Ackerman, I. Olivotto, “Clinical features and outcome of hypertrophic cardiomyopathy assocaited with triple sarcomere protein gene mutations. J Am Coll Cardiol, vol.55, pp.1444–1453, 2010.\nS. Yang, M. Hitz, G. Andelfinger, “Ventricular septal defect and restrictive cardiomyopathy in a pediatric TNNI3 mutationcarrier, Cardiol Young, vol.20, pp.574–576, 2001.\nY. Li, L. Zhang, P. Jean-Charles, C. Nan, G. Chen, J. Tian, J.-P. Jin, I. Gelb, X.P. Huang, “Dose-dependent diastolic dysfunction and early death in a mouse model with cardiac troponin mutations,” J Mol Cell Cardiology, vol.62, pp.227–236, 2013.\nJ. Du, J. Liu, H.Z. Feng, M.M. Houssain, N. Gobara, C. Zhang, Y. Li, P. Jean-Charles, J.P. Jin, X.P. Huang, “Impaired relaxation is the main manifestation in transgenic mice expressing a restrictive cardiomyopahty mutation, R193H, in cardiac TnI,” Am J Physiol Heart Circ Physiol, vol.294, pp.:H2604-H2613, 2008.\nY. Li, P. Jean-Charles, C. Nan, J. Pinto, Y. Wang, J Liang, G. Wu, J. Tian, H. Feng, J. Potter, J.-P. Jin, X.P. Huang, “Correcting diastolic dysfunction by Ca2+ desensitizing troponin in a transgenic mouse model of restrictive cardiomyopathy,” J Cell Mol Cardiol, vol. 49, pp.402–411, 2010.\nJ. Liu, J. Du, C. Zhang, J.W. Walker, X.P. Huang, “Progressive troponin I loss impaires cardiac relaxation and causes heart failure in mice,” Am J Physiol Heart Circ Physiol, vol.293, pp.H1273-H1281, 2007.\nS. Akhter, K. Bueltmann, Jr., X.P. Huang and J.-P. Jin , “Restrictive cardiomyopathy mutations demonstrate functional importance of the C-terminal end segment of troponin I,” Arch Biochem Biophys, 2013, doi:http:\u002F\u002Fdx.doi.org\u002F10.1016\u002Fj.abb.2013.12.001.\nZ. Yu, L. Zhang, J.-P. Jin, “A proteolytic NH2-terminal truncation of cardiac troponin I that is up-regulated in simulated microgravity, J Biol Chem, vol.276, pp.15753–15760, 2001.\nY. Liou, S. Kuo, S. Hsieh, \"Differential effects of a green tea-derived polyphenol (-)-epigallocatechin-3-gallate on the acidosis-induced decrease in the Ca(2+) sensitivity of cardiac and skeletal muscle,\" Pflugers Arch, vol.456, pp.787–800, 2008.\nIM. Robertson, MX. Li, BD. Sykes, “Solution structure of human cardiac troponin C in complex with the green tea polyphenol, (-)-epigallocatechin 3-gallate,” J Biol Chem, vol.284, pp.23012–23023, 2009.",{"EN":967},"Troponin, a contractile protein of the thin filament of striated muscle, consists of three subunits: troponin C (TnC), troponin T (TnT), and troponin I (TnI). Cardiac troponin I (cTnI) plays a critical role in regulation of cardiac function. The physiological effect of cTnI, as an inhibitory subunit of troponin complex, is to prevent the interaction between myosin heavy chain heads and actins, i.e. the cross-bridge formation, and to ensure a proper relaxation of cardiac myofilaments. In pathological conditions, the deficiency of cTnI or mutations in cTnI especially in the C-terminus of cTnI is associated with diastolic dysfunction caused by myofibril hypersensitivity to Ca2+. Our laboratory has generated cTnI knockout mouse model to investigate the cellular and molecular function of cTnI and created cTnI mutant disease mouse models to explore the pathophysiology caused by cTnI mutations in the heart. Here, we present our recent studies on physiological function of cTnI in the heart and the pathological consequences caused by the cTnI mutations in the diseased heart using the transgenic mouse models. The mechanisms underlying diastolic dysfunction and heart failure caused by cTnI mutations are explored in cell-based assays and in transgenic animal models. These studies provide us with useful information in searching for therapeutic strategies and target-oriented medication for the treatment of diastolic dysfunction and heart failure.",{"EN":969},"Troponin Mutation Caused Diastolic Dysfunction and Experimental Treatment in Transgenic Mice with Cardiomyopathy",{"VOID":971},"10.7603\u002Fs40782-014-0017-6","http:\u002F\u002Fwww.globalsciencejournals.com\u002Farticle\u002F10.7603\u002Fs40782-014-0017-6",[974,989,1004],{"id":975,"sortIndex":115,"researcher":26,"roles":976,"affiliations":977,"properties":986},"023674c9-0f74-4b22-b7bd-1a0033c035d2",[701],[978],{"id":26,"sortIndex":36,"affiliation":979,"properties":26},{"id":980,"createTime":981,"updateTime":981,"relativeEntities":982,"slug":26,"properties":983,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"2041aafc-2ae3-4f1a-8029-554c0fc6c61e","2024-01-17T21:36:16.149+00:00",[],{"title":984},{"VI":985},"Children’s hospital, Chongqing Medical University, Chongqing, China",{"title":987},{"VI":988},"Jie Tian",{"id":990,"sortIndex":36,"researcher":26,"roles":991,"affiliations":992,"properties":1001},"5afde5fa-2fed-4f81-848c-3e003a20928b",[701],[993],{"id":26,"sortIndex":36,"affiliation":994,"properties":26},{"id":995,"createTime":996,"updateTime":996,"relativeEntities":997,"slug":26,"properties":998,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"9753ed20-a70e-440d-99d3-595cff6fd68d","2024-01-19T05:27:37.325+00:00",[],{"title":999},{"VI":1000},"pediatrics research institute in Children’s hospital, Chongqing Medical University, Chongqing, China",{"title":1002},{"VI":1003},"Yang Xu",{"id":1005,"sortIndex":114,"researcher":26,"roles":1006,"affiliations":1007,"properties":1013},"e242c615-3f07-48a1-932c-cfc7bf15d1c6",[701],[1008],{"id":26,"sortIndex":36,"affiliation":1009,"properties":26},{"id":980,"createTime":981,"updateTime":981,"relativeEntities":1010,"slug":26,"properties":1011,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1012},{"VI":985},{"title":1014},{"VI":1015},"Xupei Huang",{"url":972,"publisher":1017,"properties":1026},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":1018,"slug":663,"properties":1019,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":1023,"manageAffiliations":1024,"indexDatabases":1025,"url":26,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":1020,"title":1021,"url":1022},{"VOID":666},{"EN":668},{"VOID":670},[],[],[],{"volume":1027,"pages":1028},{"VOID":754},{"VOID":1029},"1-5","2015-07-09",2015,{"id":1033,"createTime":1034,"updateTime":1035,"relativeEntities":1036,"slug":1037,"properties":1038,"entityType":693,"verifyStatus":25,"verifyTime":1035,"verifyNote":695,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"primaryUrl":1047,"fullTextUrl":26,"authors":1048,"publicationType":741,"publisherRelationship":1079,"citationCount":26,"citationInfo":26,"publishDate":1092,"publishYear":819,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":26,"isForceReanalyzing":759},"90ecdcce-3055-49c4-9a6c-ea1bb141c085","2024-01-07T16:22:33.539+00:00","2025-01-12T23:35:36.109+00:00",[],"Maximal-Oxygen-Uptake-and-Ventilatory-Anaerobic-Threshold-with-Pediatrics-Aged-Group-in-Non-operated-Ventricular-Septal-Defect-and-Surgically-Repaired-Tetralogy-of-Fallot",{"references":1039,"abstract":1041,"title":1043,"doi":1045},{"VOID":1040},"Bar-or O, Rowland TW. Pediatrics exercise medicine: from physiologic principle to health care application. Champaign (IL): Human kinetics, 2004, 105-111,177–191\nHoffmann JL, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol 2002; 39: 1890–1900.\nGarson A, Allen HD, Gersony WM, Gillette PC, Hohn AR, Pinsky WW, Mikhail O. The cost of congenital heart disease in children and adults: a model for multicenter assessment of price and practice variation. Arch Pediatr Adolesc Med. 1994; 148(10):1039–45\nAdams HF, Emmanouilides GC, Riemenschneider AT, Moss’ Heart disease in infants, children, and adolescents (4th Ed).Baltimore: Williams and Wilkins. 1989, 189-207,273–289\nHirth A, Reybrouck T, Bjarnason-Wehrens B, Lawrenz W, Hoffmann A. Recommendations for participation in competitive and leisure sports in patients with congenital heart disease: a consensus document. Eur J Cardiovasc Prev Rehabil. 2006; 13(3):293–99\nMurphy JG, Gersch BJ, Phil D, Mair DD, Fuster V, McGoon MD, IIstrup DM, McGoon DC, Kirklin JW, Danielson GK. Long-Term Outcome in Patients Undergoing Surgical Repair of Tetralogy of Fallot.N Engl J Med. 1993; 329:593–99\nWasserman K, Hansen JE, Sue DY. Principle of exercise testing and interpretation: including pathophysiology and clinical application. (3rd Ed).Baltimore: Lippincott Williams and Wilkins 1999, 62-94,531–540\nNorozi K, Gravenhorst V, Hobbiebrunken E, Wessel A. Normality of cardiopulmonary capacity in children operated on to correct congenital heart defects. Arch Pediatr Adolesc Med 2005;159:1063–68\nEyskens B, Reybrouck T, Bogaert J, Dymarkowsky S, Daenen W, Dumoulin M, Gewillig M. Homograft insertion for pulmonary regurgitation after repair of tetralogy of fallot improve cardiorespiratory exercise performance. Am J Cardiol 2000; 85(2):221–25\nTomassoni, Teresa L. Role of exercise in the management of cardiovascular disease in children and youth. Med Sci Sports Exerc. 1996; 28(4):406–13\nWessel HU, Paul MH. Exercise studies in tetralogy of Fallot: A review. Pediatr Cardiol. 1999; 20:39–47\nReybrouck T, Weymens M, Stijns H, Van der Hauwaert LG..Ventilatory anaerobic threshold for evaluating exercise performance in children with congenital left to right intracardiac shunt. Pediatr Cardiol 1986;7:19–24\nReybrouck T, Deroost F, Van der Hauwaert LG.Evaluation of breath-by-breath measurement of respiratory gas exchange in paediatric exercise testing. Chest.1992; 102:147–52\nWeymans T, Reybouck T. Habitual level of physical activity and cardiorespiratory endurance capacity in children. Eur J Appl Physio.1989; 58:803–07.\nBeaver WL, Wasserman K, Whipp BJ. A new method for detecting the anaerobic threshold by gas exchange. J Appl Physiol.1986; 60:2020–27\nReybrouck T, Weymans M, Stijns H, Knops J, Van der Hauwaert L.Ventilatory anaerobic threshold in healthy children. Eur J Appl Physiol.1985;54:278–84\nStuart HC, Meredith HV.Use of body measurement in the school health program. Am J Publ Health 1946; 36: 1365–86\nReybrouck T, Roger R, Weymans M, Dumoulin M, Vanh ove M, Daenen W, Van der Hauwaert L, Gewillig M. Serial cardiorespiratory exercise testing in patients with congenital heart disease. Eur J Pediatr.1995;154:801–6\nBendien C, Bossina KK, Buurma AE, Gerding AM, Kuipers JR, Landsman ML, Mook GA, Zijlstra WG. Hemodynamic effects of dynamic exercise in children and adolescents with moderate-to small ventricular septal defects.Circulation.1984; 70:929–34\nReybrouck T, Weymans M, Stijns H, Van der Hauwaert LG. Exercise testing after correction of tetralogy of fallot: The fallacy of a reduced heart rate response. Am Heart J 1986; 112(5):998–1003\nFredriksen PM, Ingjer F, Nystad W, Thaulow E. A comparison of VO2peak between patients with congenital heart disease and healthy subjects all aged 8-17 years. Eur J Appl Physiol 1999; 80: 409–16\nGillette PC, Kugler JD, Garson A Jr, Gutgesell HP, Duff DF, McNamara DG. Mechanisms of cardiac arrhythmias after the mustard operation for transposition of the great arteries. Am J Cardiol. 1980; 45(6):1225–30\nButera G, Bonnet D, Sidi D, Kachaner J, Chessa M, Bossone E, Carminati M, Villain E. Patients operated for tetralogy of fallot and with non sustained ventricular tachycardia have reduced heart rate variability. Herz 2004; 29(3):304–9\nDaliento L, Folino AF, Menti L, Zanco P, Baratella MC, Dalla Volta S. Adrenergic nervous activity in patients after surgical correction of tetralogy of fallot. J Am Coll Cardiol 2001; 38: 2043–47\nRhodes J, Curran TJ, Camil L, Rabideau N, Fulton DR, Gauthier NS, Gauvreau K, Jenkins KJ.Impact of cardiac rehabilitation on the exercise function of children with serious congenital heart disease. Pediatrics 2005; 116: 1339–45\nSingh TP, Curran TJ, Rhodes J. Cardiac rehabilitation improve heart rate recovery following peak exercise in children with repaired congenital heart disease. Pediatr Cardiol 2007;28:276–79\nGoldberg B. Sports and exercise for children with chronic health conditions. Champaign (IL): Human kinetics, 1995, 4-7,208–223\nBjarnason-Wehrens B, Dordel S, Schickendantz S, Krumm C, Bott D, Sreeram N, Brockmeier K. Motor development in children with congential cardiac diseases compared to their healthy peers. Cardiol young 2007;17:487–98",{"EN":1042},"1) To determine there is a subnormal exercise performance in children with non-operated ventricular septal defect and operated tetralogy of fallot compared to normal controls and 2) To determine physical activity is an important factor for lower exercise performance in these conditions. Retrospective Study. The data were collected from the cardio pulmonary exercise testing and physical activity questionnaire at Department of Pediatrics Cardiology and Department of Cardiovascular Rehabilitation, U.Z. Hospital, Leuven, Belgium. Exercise testing was performed on a treadmill and respiratory gas exchange was measured on a breath by breath technique using mass spectrometry (Marquette MGA 1100, Milwaukee, USA). Exercise testing was performed on a motor driven treadmill. The treadmill speed was set at 5.6 km\u002Fhr for children six years or older. The exercise tests started at 0% inclination and systematically increased 2% per minute until the patient was exhausted or symptom-limited or at target heart rate of 170 beats \u002F min were reached. The habitual level of physical activity was measured using standardized physical activity questionnaire.19 subjects with non-operated ventricular septal defect (VSD) (mean (SD) age at testing 11.6 (2.7) years) and 24 subjects who undergone surgically repaired tetralogy of Fallot (TOF) (age 12.7 (2.5) years) performed graded exercise testing and completed physical activity questionnaire were compared with 257 age matched normal controls. Subjects with non-operated ventricular septal defects compared to normal have mean and standard deviation of ventilatory anaerobic threshold (VAT) averaged 32.70 (6.76) ml kg-1 min-1 and 29.39 (2.68) ml kg-1 min-1 and maximal oxygen uptake( peak vo2) averaged 46.57 (7.83) ml min-1 kg-1 and 47.43 (4.54) ml min-1 kg-1. The unpaired t-test value showed no significance difference for maximal oxygen uptake (p=0.0790) and ventilatory anaerobic threshold (p=0. 7060) in patient with non-operated VSD compared to normal controls. Similarly, Subjects with surgically repaired tetralogy of fallot compared to normal have mean and standard deviation of ventilatory anaerobic threshold averaged 27.77 (3.09) ml kg-1 min-1 and 30.96 (2.76) ml kg-1 min-1 and maximal oxygen uptake (peak vo2) averaged 30.96 (2.76) ml min-1 kg-1 and 50.59 (4.97) ml min-1 kg-1.The unpaired t- test showed a significant difference for maximal oxygen uptake (p = 0.0005) and ventilator anaerobic threshold (p = \u003C0.0001) in patients with operated TOF compared to normal controls. The habitual level of physical activity was log transformed. There was no significance difference for physical activity (p = 0.9299) in patient with Non-operated VSD [averaged 0.68 (0.11)] compared to Normal controls [average 0.68 (0.07)]. There was a significant difference for physical activity (p =0.0043) in patients with surgically repaired TOF [averaged 0.63(0.12)] compared to normal control [averaged 0.72(0.05)] Exercise performance was reduced in patients with operated tetralogy of fallot .One of the contributing factor for reduced exercise performance seems to be reduced physical activity. Hence, physical activity has to be encouraged in subjects with reduced exercise performance namely surgically repaired tetralogy of fallot.",{"EN":1044},"Maximal Oxygen Uptake and Ventilatory Anaerobic Threshold with Pediatrics Aged Group in Non-operated Ventricular Septal Defect and Surgically Repaired Tetralogy of Fallot",{"VOID":1046},"10.7603\u002Fs40782-014-0003-z","http:\u002F\u002Fwww.globalsciencejournals.com\u002Farticle\u002F10.7603\u002Fs40782-014-0003-z",[1049,1064],{"id":1050,"sortIndex":115,"researcher":26,"roles":1051,"affiliations":1052,"properties":1061},"ae8fdde3-6957-4e6c-b8e7-b1c2f5e5b189",[701],[1053],{"id":26,"sortIndex":36,"affiliation":1054,"properties":26},{"id":1055,"createTime":1056,"updateTime":1056,"relativeEntities":1057,"slug":26,"properties":1058,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"9e71042e-9647-48b4-b2d1-757a217b869d","2024-01-07T16:22:33.555+00:00",[],{"title":1059},{"VI":1060},"Departments of Cardiovascular Rehabilitation and Paediatrics Cardiology, University Hospital Gasthuisberg and University, Leuven, Belgium",{"title":1062},{"VI":1063},"Tony Reybrouck",{"id":1065,"sortIndex":36,"researcher":26,"roles":1066,"affiliations":1067,"properties":1076},"24bd7175-a0bb-433b-921f-ef7e6a779a4a",[701],[1068],{"id":26,"sortIndex":36,"affiliation":1069,"properties":26},{"id":1070,"createTime":1071,"updateTime":1071,"relativeEntities":1072,"slug":26,"properties":1073,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"86a6f855-115e-4703-877c-3b90add7196f","2024-01-07T16:22:33.546+00:00",[],{"title":1074},{"VI":1075},"Department of Physiotherapy and Rehabilitation Pearls Health Centre, Madras Medical College, Chennai, India",{"title":1077},{"VI":1078},"Mohamed Sirajuddin Sulaiman",{"url":1047,"publisher":1080,"properties":1089},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":1081,"slug":663,"properties":1082,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":1086,"manageAffiliations":1087,"indexDatabases":1088,"url":26,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":1083,"title":1084,"url":1085},{"VOID":666},{"EN":668},{"VOID":670},[],[],[],{"volume":1090,"pages":1091},{"VOID":754},{"VOID":955},"2014-06-12",{"id":1094,"createTime":1095,"updateTime":1096,"relativeEntities":1097,"slug":1098,"properties":1099,"entityType":693,"verifyStatus":25,"verifyTime":1096,"verifyNote":695,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"primaryUrl":1108,"fullTextUrl":26,"authors":1109,"publicationType":741,"publisherRelationship":1161,"citationCount":26,"citationInfo":26,"publishDate":1174,"publishYear":819,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":26,"isForceReanalyzing":759},"0890b1ea-1d06-44c3-aad2-a3a30bc63c76","2024-02-19T23:48:42.053+00:00","2025-02-09T15:34:56.232+00:00",[],"Calcifying-Cystic-Odontogenic-Tumor-Review-with-Discussion",{"references":1100,"abstract":1102,"title":1104,"doi":1106},{"VOID":1101},"Praetorious F, Ledesma-Montes C. World Health Organization Odontogenic Tumors. Calcifying cystic odontogenic tumor. IARC Press: Lyon 2005: 313.\nSonawane K, Singaraju M, Gupta I, Singaraju S. Histopathologic diversity of Gorlin’s cyst: a study of four cases and review of literature. J Contemp Dent Pract 2011;12:392–397.\nSonone A, Sabane VS, Desai R. Calcifying ghost cell odontogenic cyst: report of a case and review of literature. Case Rep Dent. Epub 2011;3.\nDevilliers P, Talacko AA, Aldred MJ, Cure JK. Clinico- pathologic conference: case 3. Calcifying cystic odontogenic tumor (CCOT). Head Neck Pathol 2010;4: 339–342.\nAhn SG, Kim SA, Kim SG, Lee SH, Kim J, Yoon JH. Beta catenin gene alterations in a variety of so called calcifying odontogenic cysts. APIMS 2008;116:206–211.\nBuchner A, Mercell P W, Carpenter W M. Relative frequency of peripheral odontogenic tumors: A study of 45 new cases and comparison with studies from the literature. J Oral Pathol Med 2006;35:385–391.\nThinkaran M, Sivakumar P, Ramlingam S, Jeddy N, Balaguhan S. Calcifying ghost cell odontogenic cyst: A review on terminologies and classifications. J Oral Maxillofac Pathol 2012;16:450–453.\nUtumi ER, Pedron IG, Silva LP, Machado GG, Rocha AC. Different manifestation of calcifying cystic odontogenic tumor. Einstein (Sao Paulo) 2012;10:366–370.\nResende RG, Brito JA, Souza LN, Gomez RS, Mesquita RA. Peripheral calcifying odontogenic cyst: A case report and review of literature. Head and Neck Pathol 2011;5:76–80.\nUchiyama Y, Akiyama H, Murakami S, Koseki T, Kishino M, Fukuda Y, Shimizutani K, Furukawa S. Calcifying cystic odontogenic tumor: CT imaging. Br J Radiol 2012;85: 548–554.",{"EN":1103},"We report a case of calcifying cystic odontogenic tumor affecting maxilla in a 48 year old male patient presented with painless extensive intraoral swelling with unilocular radiolucency and marked resorption of roots on radiographs. Calcifying cystic odontogenic tumor (CCOT) is rare developmental odontogenic pathology. The first description of lesion was given in 1962. Various terminologies and classifications have been proposed for description of the lesion. CCOT has extraosseous and intraosseous variants. Clinically it usually presents as a slow growing painless swelling of maxilla or mandible. It commonly involves anterior region of jaws, shows no gender predilection. Radiographically the lesion has variable appearance. The most common presentation is a well defined unilocular radiolucency associated with irregular calcification. Presence of ghost cells with proliferative odontogenic epithelium is the characteristic feature of the lesion. Surgical enucleation is the treatment of choice.",{"EN":1105},"Calcifying Cystic Odontogenic Tumor: Review with Discussion",{"VOID":1107},"10.7603\u002Fs40782-014-0006-9","http:\u002F\u002Fwww.globalsciencejournals.com\u002Farticle\u002F10.7603\u002Fs40782-014-0006-9",[1110,1125,1137,1149],{"id":1111,"sortIndex":36,"researcher":26,"roles":1112,"affiliations":1113,"properties":1122},"5b2d5643-00c2-4ae7-9965-d957c848b1e1",[701],[1114],{"id":26,"sortIndex":36,"affiliation":1115,"properties":26},{"id":1116,"createTime":1117,"updateTime":1117,"relativeEntities":1118,"slug":26,"properties":1119,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"d6a96d69-7adc-482b-aaa2-7da959efb8ef","2023-12-13T00:53:12.375+00:00",[],{"title":1120},{"VI":1121},"Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, India",{"title":1123},{"VI":1124},"Ritika Jindal",{"id":1126,"sortIndex":114,"researcher":26,"roles":1127,"affiliations":1128,"properties":1134},"aeec3959-8b3d-4c50-a567-a3842994dc71",[701],[1129],{"id":26,"sortIndex":36,"affiliation":1130,"properties":26},{"id":1116,"createTime":1117,"updateTime":1117,"relativeEntities":1131,"slug":26,"properties":1132,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1133},{"VI":1121},{"title":1135},{"VI":1136},"Junaid Ahmed",{"id":1138,"sortIndex":115,"researcher":26,"roles":1139,"affiliations":1140,"properties":1146},"fcbf2c08-673a-4a01-8a34-a6027bf0e0ea",[701],[1141],{"id":26,"sortIndex":36,"affiliation":1142,"properties":26},{"id":1116,"createTime":1117,"updateTime":1117,"relativeEntities":1143,"slug":26,"properties":1144,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1145},{"VI":1121},{"title":1147},{"VI":1148},"Ravikiran Ongole",{"id":1150,"sortIndex":59,"researcher":26,"roles":1151,"affiliations":1152,"properties":1158},"f79ae0d6-6172-4c17-a379-b6cf114dbce7",[701],[1153],{"id":26,"sortIndex":36,"affiliation":1154,"properties":26},{"id":1116,"createTime":1117,"updateTime":1117,"relativeEntities":1155,"slug":26,"properties":1156,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1157},{"VI":1121},{"title":1159},{"VI":1160},"Cenna Denny",{"url":1108,"publisher":1162,"properties":1171},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":1163,"slug":663,"properties":1164,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":1168,"manageAffiliations":1169,"indexDatabases":1170,"url":26,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":1165,"title":1166,"url":1167},{"VOID":666},{"EN":668},{"VOID":670},[],[],[],{"volume":1172,"pages":1173},{"VOID":754},{"VOID":817},"2014-06-11",{"id":1176,"createTime":1177,"updateTime":1177,"relativeEntities":1178,"slug":1179,"properties":1180,"entityType":693,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"primaryUrl":1189,"fullTextUrl":26,"authors":1190,"publicationType":741,"publisherRelationship":1235,"citationCount":26,"citationInfo":26,"publishDate":1248,"publishYear":819,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":26,"isForceReanalyzing":759},"b0c0a82d-b2cf-47cf-b59d-fc39622c253c","2023-11-24T19:24:36.597+00:00",[],"Fabrication-of-Implant-Supported-Fixed-Dental-Prosthesis-Framework-CAD-CAM-as-a-Key-Player",{"references":1181,"abstract":1183,"title":1185,"doi":1187},{"VOID":1182},"Abduo J, Lyons K. Rationale for the use of CAD\u002FCAM technology in implant prosthodontics. Int J Dent. 2013;2013:768121. doi: 10.1155\u002F2013\u002F768121. Epub 2013 Apr 16.\nVult von Steyern P, Jonsson O, Nilner K. Five year evaluation of posterior all-ceramic three ï¼unit (In-Ceram) FPDs. Int J Prosthodont 2001; 14: 379-384\nOlsson KG, Furst B, Andersson B, Carlsson GE. A long-term retrospective and clinical follow-up study of In-Ceram Alumina FPDs. Int I Prosthodont 2003;16: 150-156\nSuarez MJ, Lozano JF, Paz Salido M, Martinez F. Three-year clinical evaluation of In-Ceram Zirconia posterior FPDs. Int J Prosthodont 2004; 17: 35-38\nEsquivel-Upshaw JF, Anusavice KJ, Young H, Jones J, Gibbs C. Clinical performance of Lithia disilicatebased core ceramic for three-unit posterior FPDs. Int J Prosthodont 2004; 17: 469-475\nOden A, Andersson M, Krystek-Ondracek I, Magnusson D. Five-year clinical evaluation of Procera AllCeram crowns. J Prosthet Dent 1998; 80: 450-456\nChristel P, Meunier A, Heller M, Torre JP, Peille CN. Mechanical properties and short-term in ï¼vitvo evaluation of yttrium-oxide-partially-stabilized zirconia. J Biomed Mater Res 1989; 23: 45-61\nFilser F, Kocher P, Weibe F, Luthy H, Scharer P, Gauckler LJ. Reliability and strength of all-ceramic dental restorations fabricated by direct ceramic machining (DCM). Int J Comput Dent 2001; 4: 89-106\nBesimo CE, Spielmann HP, Rohner HP. Computerassisted generation of all-ceramic crowns and fixed partial dentures. Int J Comput Dent 2001; 4: 43-62\nSuttor D, Bunke K, Hoescheler S, Hauptmann H, Hertlein G. LAVA-the system for all-ceramic ZrO2 crowns and bridge frameworks. Int J Comput Dent 2001; 4: 195-206\nTakashi MIYAZAKI, Yasuhiro HOTTA, Jun KUN II, Soichi KURIYAMA and Yukimichi TAMAKI A review of dental CAD\u002FCAM: current status and future perspectives from 20 years of experience. Dental Materials Journal 2009; 28(1):44-56\nDrago C, Saldarriaga RL, Domagala D, Almasri R. Volumetric determination of the amount of misfit in CAD\u002FCAM and cast implant frameworks: a multicenter laboratory study. Int J Oral Maxillofac Implants. 2010 Sep-Oct;25(5):920-9.\nKatsoulis J, Mericske-Stern R, Rotkina L, Zbären C, Enkling N, Blatz MB. Precision of fit of implant-supported screw-retained 10-unit computer-aided-designed and computer-aided-manufactured frameworks made from zirconium dioxide and titanium: an in vitro study. Clin Oral Implants Res. 2014 Feb;25(2):165-74.\nHassel AJ, Shahin R, Kreuter A, Rammelsberg P. Rehabilitation of an edentulous mandible with an implant-supported fixed prosthesis using an all-ceramic framework: a case report. Quintessence Int. 2008 May;39(5):421-6.\nZaghloul HH, Younis JF. Marginal fit of implant-supported all-ceramic zirconia frameworks. J Oral Implantol. 2013 Aug;39(4):417-24.\nDittmer MP, Nensa M, Stiesch M, Kohorst P. J Appl Oral Sci. 2013 Jul-Aug;21(4):307-13.\nAbduo J, Bennani V, Lyons K, Waddell N, Swain M. A novel in vitro approach to assess the fit of implant frameworks. Clin Oral Implants Res. 2011 Jun;22(6):658-63.\nSpazzin AO, Dos Santos MB, Sobrinho LC, Consani RL, Mesquita MF. Effects of horizontal misfit and bar framework material on the stress distribution of an overdenture-retaining bar system: a 3D finite element analysis. J Prosthodont. 2011 Oct;20(7):517-22.\nTurkyilmaz I, Asar NV A technique for fabricating a milled titanium complete-arch framework using a new CAD\u002FCAM software and scanner with laser probe. Tex Dent J. 2013 Jul;130(7):586-92.\nTakaba M, Tanaka S, Ishiura Y, Baba K. Implant-supported fixed dental prostheses with CAD\u002FCAM-fabricated porcelain crown and zirconia-based framework. J Prosthodont. 2013 Jul;22(5):402-7.\nIlser Turkyilmaz and Roxanna J. Nicoll State-of-the-Art Technology in Implant Dentistry: CAD\u002FCAM www.intechopen.com 219-250",{"EN":1184},"To know the importance of CAD\u002FCAM in the fabrication of implant retained prosthesis framework Review of the studies showing the fit of the implant prosthesis framework fabricated by CAD\u002FCAM Initially, CAD\u002FCAM was used to fabricate implant components from titanium and titanium alloy. To date, CAD\u002FCAM is the only way of producing implant components from high-strength ceramics such as densely sintered alumina and partially stabilized zirconia. The accuracy can be measured by vertical fit of CAD\u002FCAM frameworks ranged from 1 to 27μm which was significantly better than cast implant frameworks. In addition, a similar level of fit was observed for implant CAD\u002FCAM frameworks produced from zirconia and titanium. CAD\u002FCAM produces zirconia workpieces that require no subsequent alteration, unnecessary weakening is avoided. This ensures durability of the prosthesis. Maximal abutment and framework thickness is desirable and increases the fracture resistance. The risk of veneering ceramic fracture is expected to be minimized in the future by the continuously improving veneering strategies. In comparison to the lost wax\u002Fcasting protocol, CAD\u002FCAM is much simpler and requires less technical time and involvement. The whole CAD\u002FCAM process is fully automated following the scanning step. CAD\u002FCAM plays a key role in fabrication of implant prosthesis framework because of bypassing most of the laboratory works and manual handling. By using CAD\u002FCAM frameworks, fixed partial or full-arch dental prostheses can be fabricated. Application of CAD\u002FCAM is cost effective as well as less chair-side adjustments required especially with prosthesis requiring frameworks.",{"EN":1186},"Fabrication of Implant Supported Fixed Dental Prosthesis Framework - CAD\u002FCAM as a Key Player",{"VOID":1188},"10.7603\u002Fs40782-014-0005-x","http:\u002F\u002Fwww.globalsciencejournals.com\u002Farticle\u002F10.7603\u002Fs40782-014-0005-x",[1191,1206,1223],{"id":1192,"sortIndex":36,"researcher":26,"roles":1193,"affiliations":1194,"properties":1203},"662c3f76-eb2e-4c0c-a3a4-e1749134a49d",[701],[1195],{"id":26,"sortIndex":36,"affiliation":1196,"properties":26},{"id":1197,"createTime":1198,"updateTime":1198,"relativeEntities":1199,"slug":26,"properties":1200,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"8977d6f4-4a3c-40a3-a93f-7944ead5a6e9","2023-12-23T21:49:09.772+00:00",[],{"title":1201},{"VI":1202},"Department of Prosthodontics, Manipal College of Dental Sciences, Manipal University, Mangalore, India",{"title":1204},{"VI":1205},"Mahesh Mundathaje",{"id":1207,"sortIndex":114,"researcher":26,"roles":1208,"affiliations":1209,"properties":1220},"5e55d9fd-ed2d-46bb-901b-842719873aa6",[701],[1210],{"id":26,"sortIndex":36,"affiliation":1211,"properties":26},{"id":1212,"createTime":1213,"updateTime":1214,"relativeEntities":1215,"slug":1216,"properties":1217,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"fa38ae55-58cd-4437-a71f-ed5432c936d0","2023-05-09T03:39:08.789+00:00","2026-06-18T23:32:15.386+00:00",[],"Khoa%20Ho%C3%A1%20tr%E1%BB%8B%20-%20Trung%20t%C3%A2m%20Ung%20b%C6%B0%E1%BB%9Bu%20-%20B%E1%BB%87nh%20vi%E1%BB%87n%20Qu%C3%A2n%20y%20103",{"title":1218},{"VI":1219},"Khoa Hoá trị - Trung tâm Ung bướu - Bệnh viện Quân y 103",{"title":1221},{"VI":1222},"Lakshmipallavi Kabekkodu",{"id":1224,"sortIndex":115,"researcher":26,"roles":1225,"affiliations":1226,"properties":1232},"1e1b50ce-e12c-402f-b3d8-9a1209678aa8",[701],[1227],{"id":26,"sortIndex":36,"affiliation":1228,"properties":26},{"id":1212,"createTime":1213,"updateTime":1214,"relativeEntities":1229,"slug":1216,"properties":1230,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1231},{"VI":1219},{"title":1233},{"VI":1234},"Shobha Rodrigues",{"url":1189,"publisher":1236,"properties":1245},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":1237,"slug":663,"properties":1238,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":1242,"manageAffiliations":1243,"indexDatabases":1244,"url":26,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":1239,"title":1240,"url":1241},{"VOID":666},{"EN":668},{"VOID":670},[],[],[],{"volume":1246,"pages":1247},{"VOID":754},{"VOID":955},"2014-06-09",{"id":1250,"createTime":1251,"updateTime":1252,"relativeEntities":1253,"slug":1254,"properties":1255,"entityType":693,"verifyStatus":25,"verifyTime":1252,"verifyNote":695,"syncStatus":28,"languages":1264,"translateLanguages":26,"viewCount":36,"primaryUrl":1265,"fullTextUrl":26,"authors":1266,"publicationType":741,"publisherRelationship":1335,"citationCount":26,"citationInfo":26,"publishDate":1248,"publishYear":819,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":1345,"isForceReanalyzing":759},"b190663d-d352-45d7-a5fe-cf841eaab7c5","2024-04-11T08:05:55.631+00:00","2025-01-22T11:25:35.818+00:00",[],"A-Functional-Univentricle-Large-Ventricular-Septal-Defect-Atrioventricular-Discordance-Malposition-of-the-Great-Arteries-Pulmonary-Stenosis-and-Major-Aorto-Pulmonary-Collaterals",{"keywords":1256,"abstract":1258,"title":1260,"doi":1262},{"EN":1257},"",{"EN":1259},"We report a case of a 25 year-old male with a functionally univentricular heart. He underwent consult for clearance prior to employment and has been asymptomatic since childhood with good functional capacity, his 6 minute walk test was normal at 300 meters. Pertinent physical findings were a right ventricular heave, a grade 3\u002F6 systolic murmur over the 2nd-3rd intercostal spaces left parasternal border, a continuous murmur over the interscapular area and cyanosis of the nailbeds. Laboratory exams showed mild erythrocytosis and hypoxemia. Transthoracic and transesophageal echocardiographic findings showed a large ventricular septal defect (apical intraventricular septum remnant), atrioventricular discordance, malposition of the great arteries and severe pulmonary stenosis. Major aorto-pulmonary collaterals were demonstrated on hemodynamics study. Patient is stable and living a normal life but advised to avoid moderate to heavy strenuous activities. He is on a regular follow – up at our out patient clinic and there are no planned immediate surgical interventions at present.",{"EN":1261},"A Functional Univentricle: Large Ventricular Septal Defect, Atrioventricular Discordance, Malposition of the Great Arteries, Pulmonary Stenosis, and Major Aorto Pulmonary Collaterals",{"VOID":1263},"10.7603\u002Fs40782-014-0004-y",[102],"http:\u002F\u002Fwww.globalsciencejournals.com\u002Farticle\u002F10.7603\u002Fs40782-014-0004-y",[1267,1283,1299,1311,1323],{"id":1268,"sortIndex":59,"researcher":26,"roles":1269,"affiliations":1270,"properties":1280},"9de33e35-6f26-4449-9a33-01d203fecd15",[],[1271],{"id":26,"sortIndex":36,"affiliation":1272,"properties":26},{"id":1273,"createTime":1274,"updateTime":1274,"relativeEntities":1275,"slug":1276,"properties":1277,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"d6cdbda1-d966-4b65-8962-2d07eb078da2","2024-04-11T08:05:55.695+00:00",[],"Section-of-Pedriatric-Cardiology-University-of-the-Philippines-Philippine-General-Hospital-UP-PGH-Manila-Philippines",{"title":1278},{"EN":1279},"Section of Pedriatric Cardiology, University of the Philippines- Philippine General Hospital (UP-PGH), Manila, Philippines",{"title":1281},{"EN":1282},"Maycibel Macadaeg-Capero",{"id":1284,"sortIndex":36,"researcher":26,"roles":1285,"affiliations":1286,"properties":1296},"1f049973-8fc4-4bbc-917f-ab28eb3843e2",[],[1287],{"id":26,"sortIndex":36,"affiliation":1288,"properties":26},{"id":1289,"createTime":1290,"updateTime":1290,"relativeEntities":1291,"slug":1292,"properties":1293,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"a334b7e3-9b6e-43c3-a89a-d1e432c04e19","2024-04-11T08:05:55.664+00:00",[],"Section-of-Cardiology-University-of-the-Philippines-Philippine-General-Hospital-UP-PGH-Manila-Philippines",{"title":1294},{"EN":1295},"Section of Cardiology, University of the Philippines- Philippine General Hospital (UP-PGH), Manila, Philippines",{"title":1297},{"EN":1298},"Cristine Catindig-Santelices",{"id":1300,"sortIndex":111,"researcher":26,"roles":1301,"affiliations":1302,"properties":1308},"a157f545-e490-47e2-aac4-91c709d39f8c",[],[1303],{"id":26,"sortIndex":36,"affiliation":1304,"properties":26},{"id":1289,"createTime":1290,"updateTime":1290,"relativeEntities":1305,"slug":1292,"properties":1306,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1307},{"EN":1295},{"title":1309},{"EN":1310},"Frederick P. Gloria",{"id":1312,"sortIndex":115,"researcher":26,"roles":1313,"affiliations":1314,"properties":1320},"93ca8a71-c823-4045-904d-81d47c79e124",[],[1315],{"id":26,"sortIndex":36,"affiliation":1316,"properties":26},{"id":1289,"createTime":1290,"updateTime":1290,"relativeEntities":1317,"slug":1292,"properties":1318,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1319},{"EN":1295},{"title":1321},{"EN":1322},"Michael Joseph T. Reyes",{"id":1324,"sortIndex":114,"researcher":26,"roles":1325,"affiliations":1326,"properties":1332},"aedafdc9-ed31-4a26-a047-a46ef0611a5c",[],[1327],{"id":26,"sortIndex":36,"affiliation":1328,"properties":26},{"id":1289,"createTime":1290,"updateTime":1290,"relativeEntities":1329,"slug":1292,"properties":1330,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1331},{"EN":1295},{"title":1333},{"EN":1334},"Melgar Matulac",{"url":26,"publisher":1336,"properties":26},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":1337,"slug":663,"properties":1338,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":1342,"manageAffiliations":1343,"indexDatabases":1344,"url":26,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":1339,"title":1340,"url":1341},{"VOID":666},{"EN":668},{"VOID":670},[],[],[],[1346,1348,1350,1352,1354,1356,1358,1360],{"id":26,"text":1347,"url":26,"identifiers":26},"Khairy P, Poirier N, Mercier LA. Univentricular Heart. Circulation 2007; 115:800– 812.",{"id":26,"text":1349,"url":26,"identifiers":26},"Anderson RH, Becker AE, Wilkinson JL. Proceedings: morphogenesis and nomenclature of univentricular hearts. Br Heart J. 1975; 37:781– 782.",{"id":26,"text":1351,"url":26,"identifiers":26},"Anderson HA, Baker EJ, Penny D, et al… Pedriatric Cardiology. 3rd edition; Elsevier; 2010.",{"id":26,"text":1353,"url":26,"identifiers":26},"Samanek M. Children with congenital heart disease: probability of natural survival. Pediatr Cardiol. 1992; 13:152– 8.",{"id":26,"text":1355,"url":26,"identifiers":26},"Hager A, Laemmerer H, Eicken A, Fratz S, Hess J et al… Long-term survival of patients with Univentricular heart not treated surgically. The Journal of Thoracic and Cardiovascular Surgery 2002; 123:1214– 1217.",{"id":26,"text":1357,"url":26,"identifiers":26},"Van Praagh R, Papagiannis, Grunenfelder J, et al… Pathologic anatomy of corrected transposition of the great arteries: Medical and surgical implications. Am Heart J 1998; 135: 772– 785.",{"id":26,"text":1359,"url":26,"identifiers":26},"Allwork SP, Bentall HH, Becker AE, et al… Congenitally corrected transposition of the great arteries: morphologic study of 32 cases. Am J Cardiol 1976; 38: 910– 923.",{"id":26,"text":1361,"url":26,"identifiers":26},"Michael, S. Chen; Adel, Younoszai; Hitinder, S. Gurm; Craig, R. Asher: Images in Cardiovascular Medicine: Univentricular Heart. Circulation. 2004; 109:2030.",{"id":1363,"createTime":1364,"updateTime":1365,"relativeEntities":1366,"slug":1367,"properties":1368,"entityType":693,"verifyStatus":25,"verifyTime":1365,"verifyNote":695,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"primaryUrl":1377,"fullTextUrl":26,"authors":1378,"publicationType":741,"publisherRelationship":1430,"citationCount":26,"citationInfo":26,"publishDate":1174,"publishYear":819,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":26,"isForceReanalyzing":759},"45b8a365-2bdb-4ed4-addd-dd639e2c3022","2024-01-04T06:20:38.894+00:00","2025-02-14T16:36:23.364+00:00",[],"Manual-and-Electronic-Detection-of-Subgingival-Calculus-Reliability-and-Accuracy",{"references":1369,"abstract":1371,"title":1373,"doi":1375},{"VOID":1370},"D. J. White, “Dental calculus: recent insights into occurrence, formation, prevention, removal and oral health effect of supragingival and subgingival deposits”. Eur J Oral Sci. 1997;105:pp. 508–522.\nJ. Lindhe, E. Westfelt, S. Nyman, “Long term effect of surgical and nonsurgical treatment of periodontal disease”. Journal of Clinical Periodontology 1984;11: pp. 448–58.\nJ. Friskopp, G. A. Isacsson, “Quantitative icroradiographic study of the mineral content of supragingival and subgingival dental calculus”. Scandinavian Journal of Dental Research 1984;92: pp. 25–32.\nB. Orban, F. M. Wentz, F. G. Everett, D. A. Grant, “Periodontics, A Concept Theory and Practice”. St Louis: CV Mosby Co; 1958:103.\nS. B. Low, “Clinical considerations in non surgical mechanical therapy”, Periodontology 2000, 1995;9: pp. 23–26.\nK. H. Calley and K. O. Hodges, “ Automat your probing process: how technical advances are changing the way probing depths are measured and recorded, The Journal of Professional Excellence - Dimention of Dental Hygiene 2011;9(2): pp. 44–47.\nD. J. Pippin and P. Feil, “Intepreter agreement on subgingival calculus detection following scaling”, J Dent Educ 1992;56: pp. 322–6.\nR. S. Johansson and K.J. Cole, “Sensory-motor coordination during grasping and manipulative actions”. Curr Opin Neurobiol 1992;2 (June): pp. 815–23.\nG. Atilla and S. Kandemir, “Evaluation of surface smoothness detected by a periodontal probe”, J. Nihon Univ Sch Dent 1994;36(Apr): pp. 2615.\nF. Matthias, H. Richard, M. Albert M, and R. Hickel, “ The effectiveness of InGaAsp Diode Laser Radiation to detect subgingival calculus as compared to an explorer”, J Periodontal 2004;75:pp.744–749.\nPerioscan Sirona Australia - Ultrasonic instrument; Code 6030337 “The first ultrasonic unit for diagnosis and therapy all-in-one.\nT. W.Cutress, J. Ainam, J. Sardo-Infirri, “ The community periodontal index of treatment need (CPITN) procedure for population groups and individuals, International Dental Journal 1987; 37(4): pp. 222–233.\nG. Meissner, B. Oehme, J. Strackeljan and T. Kocher, “A new system to detect residual subgingival calculus: in vitro detection limits”, Journal of Clinical Periodontology 2006;33(March): pp. 195–199.\nV. Benhamou, “Calculus detection goes high tech.” Dimensions of dental hygiene 2003;1(March): pp. 16–18.\nB. M. Bushari, P. J. Chitnis and K. A. Banavali, “Advances in calculus detection and removal technologies - a review”, Indian Journal of Research 2013; Volume 2(January) issue 1: pp. 124–125.\nS. R. Srinivas, S. M. Dhoom, S. Nagarajappa, B. Vidya and A. Janardhan, “A periodontal probing”, Dentistry India Compendium 2009;3(May): pp. 32–40.\nC. F. Becherer, K. H. Rateitschak and A. F. Hefti, “Comparative probing with an electronic and a manual periodontal probe”, Pubmed 2008;8: 651–657.\nC. H. Ray, “Accurate calculus detection: is it possible?”, ADEA\u002FAADR\u002FCADR Meeting and Exhibition 2006: Educational Research Presentation.\nJ. Mascarenhas, S. Blanchard, D. Newell, B Hancock, M. Kowolick, and G. Eckert, “Use of optical detection system for detecting subgingival calculus”:http:\u002F\u002Fiadr.confex.com\u002Fiadr\u002F2006Orld\u002Ftechprogramforcd\u002FA763.htm.",{"EN":1372},"Calculus consists of mineralised dental biofilm on the surfaces of teeth and dental prosthesis, the location of which can be detected by using a periodontal or an electronic probe. Detection of subgingival calculus is critical for successful treatment outcome in the management of periodontal patients. The aim of this study was to detect subgingival calculus using manual and electronic probe and to compare the reliability and the accuracy of both methods. The study was carried out in vitro on thirty-two extracted teeth with calculus mounted in frasaco model. A total of 192 sites on six surfaces of the teeth bucally and lingually were recorded for the presence of subgingival calculus. Manual probing of calculus depended on tactile sensation and experience; where as electronic probing gave sound and light signal. The results showed that at the depth of 1-3 mm, manual probing could detect 62.7% of calculus and electronic probing could detect more at 77.1%. At the deeper sites of 4-6mm, the ability for detection using electronic probing reduced to 14.1% with failure for detection at ≥ 7mm depth. However manual probing recorded more at 25% for 4-6 mm calculus and 4.7% at ≥7mm. Manual and electronic probing has different sensitivity in detecting subgingival calculus with electronic probing being more sensitive at shallow sites and failed to detect calculus at deeper sites. It also has difficulty to differentiate between calculus and other roughness on tooth surfaces. These findings highlighted the accuracy and reliability of manual detection for deeper calculus. Redesigning calibration and length of electronic probe can improve its usage. Further study on clinical application to assess the impact of both probing may benefit clinical teaching of subgingival calculus detection and the outcome of periodontal patient’s management.",{"EN":1374},"Manual and Electronic Detection of Subgingival Calculus: Reliability and Accuracy",{"VOID":1376},"10.7603\u002Fs40782-014-0008-7","http:\u002F\u002Fwww.globalsciencejournals.com\u002Farticle\u002F10.7603\u002Fs40782-014-0008-7",[1379,1394,1406,1418],{"id":1380,"sortIndex":59,"researcher":26,"roles":1381,"affiliations":1382,"properties":1391},"642c8f8d-de9b-4142-b9e8-3f9b976ca67e",[701],[1383],{"id":26,"sortIndex":36,"affiliation":1384,"properties":26},{"id":1385,"createTime":1386,"updateTime":1386,"relativeEntities":1387,"slug":26,"properties":1388,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"3f5e79e4-1087-43c9-b058-b2781c66bdeb","2024-01-04T06:20:38.929+00:00",[],{"title":1389},{"VI":1390},"Faculty of Dentistry, University Teknologi MARA, Kuala Lumpur, Malaysia",{"title":1392},{"VI":1393},"N. A. H. Mohamed",{"id":1395,"sortIndex":36,"researcher":26,"roles":1396,"affiliations":1397,"properties":1403},"c1378851-c6d6-4ab1-9f57-341eb6a3101d",[701],[1398],{"id":26,"sortIndex":36,"affiliation":1399,"properties":26},{"id":1385,"createTime":1386,"updateTime":1386,"relativeEntities":1400,"slug":26,"properties":1401,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1402},{"VI":1390},{"title":1404},{"VI":1405},"M. Masud",{"id":1407,"sortIndex":114,"researcher":26,"roles":1408,"affiliations":1409,"properties":1415},"bfde7a76-604d-4441-ade9-518b4ddee969",[701],[1410],{"id":26,"sortIndex":36,"affiliation":1411,"properties":26},{"id":1385,"createTime":1386,"updateTime":1386,"relativeEntities":1412,"slug":26,"properties":1413,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1414},{"VI":1390},{"title":1416},{"VI":1417},"A. S. N. Sameon",{"id":1419,"sortIndex":115,"researcher":26,"roles":1420,"affiliations":1421,"properties":1427},"6e59d39a-1c04-4698-a581-d877da1f5b40",[701],[1422],{"id":26,"sortIndex":36,"affiliation":1423,"properties":26},{"id":1385,"createTime":1386,"updateTime":1386,"relativeEntities":1424,"slug":26,"properties":1425,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1426},{"VI":1390},{"title":1428},{"VI":1429},"H. I. M. Zahari",{"url":1377,"publisher":1431,"properties":1440},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":1432,"slug":663,"properties":1433,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":1437,"manageAffiliations":1438,"indexDatabases":1439,"url":26,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":1434,"title":1435,"url":1436},{"VOID":666},{"EN":668},{"VOID":670},[],[],[],{"volume":1441,"pages":1442},{"VOID":754},{"VOID":1029}]