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Trop Med Infect Dis 2(3):36. https:\u002F\u002Fdoi.org\u002Fhttps:\u002F\u002Fdoi.org\u002F10.3390\u002Ftropicalmed2030036\nWHO (2020) Fact sheets. Soil-transmitted helminth infections. https:\u002F\u002Fwww.who.int\u002Fnews-room\u002Ffact-sheets\u002Fdetail\u002Fsoil-transmitted-helminth-infections. Accessed 16 April 2020\nSalam N, Azam S (2017) Prevalence and distribution of soil-transmitted helminth infections in India. BMC Public Health 17(1):201. https:\u002F\u002Fdoi.org\u002Fhttps:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12889-017-4113-2\nDeori K, Yadav AK (2016) Anthelmintic effects of Oroxylum indicum stem bark extract on juvenile and adult stages of Hymenolepis diminuta (Cestoda), an in vitro and in vivo study. Parasitol Res 115(3):1275–1285. https:\u002F\u002Fdoi.org\u002Fhttps:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00436-015-4864-6\nOzioma EOJ, Chinwe OAN (2019) Herbal medicine. In: Builders P (ed) Herbal medicines in African traditional medicine. IntechOpen. http:\u002F\u002Fdx.doi.org\u002Fhttps:\u002F\u002Fdoi.org\u002F10.5772\u002Fintechopen.80348\nChanda S, Parekh J, Vaghasiya Y, Dave R, Baravalia Y, Nair R (2015) Medicinal plants - from traditional use to toxicity assessment: a review. Int J Pharm Sci Res 6(7):2652–2670. https:\u002F\u002Fdoi.org\u002Fhttps:\u002F\u002Fdoi.org\u002F10.13040\u002FIJPSR.0975-8232.6(7).2652-70\nGogoi S, Yadav AK (2017) Therapecutic efficacy of the leaf extract of Croton joufra Roxb. Against experimental cestodiasis in rats. J Parasit Dis 41(2):417–422. https:\u002F\u002Fdoi.org\u002Fhttps:\u002F\u002Fdoi.org\u002F10.1007\u002Fs12639-016-0819-9\nGogoi S, Yadav AK (2016) In vitro and in vivo anthelmintic effects of Caesalpinia bonducella (L.) Roxb. Leaf extract on Hymenolepis diminuta (Cestoda) and Syphacia obvelata (Nematoda). J Intercult Ethnopharmacol 5(4):427–433. https:\u002F\u002Fdoi.org\u002Fhttps:\u002F\u002Fdoi.org\u002F10.5455\u002Fjice.20160821024821\nBhandari MM (1978) Flora of Indian Desert. Jodhpur, India, Scientific Publishers\nIndia Biodiversity Portal (2020) Cyperus compressus. L. https:\u002F\u002Findiabiodiversity.org\u002Fspecies\u002Fshow\u002F229407. Accessed 23 July 2020.\nSoren AD, Yadav AK, Dhar ED (2019) Toxological evaluation of Cyperus compressus Linn. A traditionally used anthelmintic plant in India. Orient Pharm Exp Med 2019:1–6. https:\u002F\u002Fdoi.org\u002Fhttps:\u002F\u002Fdoi.org\u002F10.1007\u002Fs13596-019-00413-w\nDangol DR, Gurung SB (1991) Ethnobotany of the Tharu tribe of Chitwan district, Nepal. Int J Pharmacogn 29(3):203–209. https:\u002F\u002Fdoi.org\u002Fhttps:\u002F\u002Fdoi.org\u002F10.3109\u002F13880209109082879\nDavuluri T, Chennuru S, Pathipati M, Krovvidi S, Rao GS (2020) In vitro anthelmintic activity of three tropical plant extracts on Haemonchus contortus. Acta Parasitol 65(1):11–18. https:\u002F\u002Fdoi.org\u002Fhttps:\u002F\u002Fdoi.org\u002F10.2478\u002Fs11686-019-00116-x\nIshnava KB, Konar PS (2020) In vitro anthelmintic activity and phytochemical characterization of Corallocarpus epigaeus (Rottler) Hook. f. tuber from ethyl acetate extracts. Bull Natl res cent 44:33. https:\u002F\u002Fdoi.org\u002Fhttps:\u002F\u002Fdoi.org\u002F10.1186\u002Fs42269-020-00286-z\nYongwa G, Ngnoda BFNF, Ndjonka D, Saotoing P (2020) In vitro anthelmintic activity of aqueous and ethanolic extract of Senna italica (Caesalpiniaceae) on three-stages of Haemonchus contortus. J Pharm Res Int 32(3):25–34. https:\u002F\u002Fdoi.org\u002Fhttps:\u002F\u002Fdoi.org\u002F10.9734\u002Fjpri\u002F2020\u002Fv32i330411\nRates SMK (2001) Plants as source of drugs. Toxicon 39:603–613. https:\u002F\u002Fdoi.org\u002Fhttps:\u002F\u002Fdoi.org\u002F10.1016\u002FS0041-0101(00)00154-9\nOECD 407 (2008) OECD guidelines for testing of chemicals. Organization for Economic Co-operation and Development, Paris, France\nTrease GE, Evans WC (2002) Pharmacognosy, 15th edn. Saunders Publishers, London\nSofowora A (1993) Screening plants for bioactive agents, Medicinal plants and traditional medicine in Africa, 2nd edn. Spectrum Books Limited, Sunshine House, Ibadan, Nigeria\nGirach RD, Khan H, Ahmad M (2003) Botanical identification of Thuhar, seldom used as Unani medicine. Hamdard Med XLVI (1):27–33\nRameshkumar KB, Sudheesh N, George V, Mohanan N (2011) Volatile constituents of the roots of Cyperus compressus Linn. J Essent Oil Res 23(3):39–41. https:\u002F\u002Fdoi.org\u002Fhttps:\u002F\u002Fdoi.org\u002F10.1080\u002F10412905.2011.9700455\nDatta S, Seal T, Sinha BK, Bhattacharjee S (2018) RP-HPLC based evidences of rich sources of phenolics and water-soluble vitamins in an annual sedge Cyperus compressus. J Phytopharmacol 7(3):305–311",{"EN":107},"The decoction of the roots of Cyperus compressus (Cyperaceae) is used to treat helminth infection by the Santhal tribe of Assam. The study evaluated the anthelmintic efficacy claims of the plant C. compressus through pre-clinical in vitro and in vivo studies employing available parasite-animal models such as Hymenolepis diminuta-Wistar rat (cestode) and Syphacia obvelata-Swiss mice (nematode) models. Phytochemical analysis revealed the presence of alkaloids, glycosides, reducing sugars, flavonoids, terpenoids, tannins, and steroids. In vitro studies were conducted employing H. diminuta and S. obvelata. In vitro studies against H. diminuta revealed mortality of parasites at 8.3 ± 0.05 h at the highest concentration of C. compressus methanolic root extract (30 mg\u002Fml), whereas reference drug praziquantel (PZQ), showed mortality at 5.84 ± 0.01 h. Against S. obvelata, in the same concentration of the extract, mortality of parasites occurred in a much later time of 24.13 ± 0.03 h, whereas in the reference drug albendazole (ABZ), the parasites showed mortality at 7.24 ± 0.08 h. In vivo studies against H. diminuta revealed 61.74% reduction in the eggs per gram (EPG) counts and 24% reduction in worm counts at the highest dose of 700 mg\u002Fkg body weight (b.w.) of plant extract. Against S. obvelata, at 700 mg\u002Fkg b.w., 28.92% and 33.85% reduction in EPG and worm counts were recorded respectively. Although the reference drugs showed better in vitro and in vivo efficacy, the plant extract showed a better in vitro efficacy against cestode parasite compared to its nematode counterpart indicating that it possesses a better cestocidal efficacy. EPG reductions were higher against H. diminuta, whereas worm count reduction was higher against S. obvelata. The findings justify the use of C. compressus as an anthelmintic in the traditional medicine of the Santhals of India.",{"EN":109},"Evaluation of in vitro and in vivo anthelmintic efficacy of Cyperus compressus Linn., a traditionally used anthelmintic plant in parasite-animal models",{"VOID":111},"10.1186\u002Fs43094-020-00148-5","PUBLICATION","VERIFIED","2024-12-12T23:53:10.922+00:00","Auto Verify","https:\u002F\u002Ffjps.springeropen.com\u002Farticles\u002F10.1186\u002Fs43094-020-00148-5",[118,135],{"id":119,"sortIndex":21,"researcher":20,"roles":120,"affiliations":122,"properties":132},"9390d1e2-be92-4ec9-a435-2cbf95238cac",[121],"AUTHOR",[123],{"id":20,"sortIndex":21,"affiliation":124,"properties":20},{"id":125,"createTime":126,"updateTime":126,"relativeEntities":127,"slug":128,"properties":129,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"46b8fbb0-6356-4c18-9adc-382f256ea8d9","2024-04-07T19:55:03.283+00:00",[],"Department-of-Zoology-B-Borooah-College-Guwahati-India",{"title":130},{"VI":131},"Department of Zoology, B. Borooah College, Guwahati, India",{"title":133},{"VI":134},"Amar Deep Soren",{"id":136,"sortIndex":137,"researcher":20,"roles":138,"affiliations":139,"properties":148},"fc58d2b8-5e8c-4dcc-9f43-80d45f6433ee",1,[121],[140],{"id":20,"sortIndex":21,"affiliation":141,"properties":20},{"id":142,"createTime":143,"updateTime":143,"relativeEntities":144,"slug":20,"properties":145,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"3df5f0eb-36b6-42ff-b79a-93ca37d7904c","2023-12-13T05:21:32.104+00:00",[],{"title":146},{"VI":147},"Department of Zoology, North-Eastern Hill University, Shillong, India",{"title":149},{"VI":150},"Arun Kumar Yadav","ARTICLE",{"url":116,"publisher":153,"properties":174},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":154,"slug":10,"properties":155,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":159,"manageAffiliations":160,"indexDatabases":161,"url":20,"thumbnailPath":20,"statistic":169,"gsStatistic":20,"type":92,"analyzePriority":20},[],{"issn":156,"title":157,"url":158},{"VOID":13},{"EN":15},{"VOID":17},[],[],[162],{"id":44,"indexDatabase":163,"url":59,"indexYears":20,"academicFieldIds":168,"indexDatabaseRanking":20},{"id":46,"createTime":47,"updateTime":48,"relativeEntities":164,"label":165,"description":166,"key":55,"publicationTags":167,"standard":20},[],{"EN":51,"VI":51},{"VI":53,"EN":54},[57,58],[61],{"impactFactor":21,"impactFactorByYear":170,"i10Index":68,"i10IndexLast5Year":69,"totalPublication":70,"totalPublicationByYear":171,"totalCitation":80,"totalCitationByYear":172,"totalCitationPerPublication":86,"totalCitationPerPublicationByYear":173,"hindexLast5Year":68,"hindex":68},{"2020":64,"2021":65,"2022":66,"2023":67},{"2015":72,"2016":72,"2017":69,"2018":73,"2019":74,"2020":75,"2021":76,"2022":77,"2023":78,"2024":79},{"2019":82,"2020":83,"2021":84,"2022":85},{"2019":88,"2020":89,"2021":90,"2022":91},{"volume":175,"pages":177},{"VOID":176},"6",{"VOID":178},"1-6","2020-12-04",2020,false,{"id":183,"createTime":184,"updateTime":185,"relativeEntities":186,"slug":187,"properties":188,"entityType":112,"verifyStatus":113,"verifyTime":185,"verifyNote":115,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":197,"fullTextUrl":20,"authors":198,"publicationType":151,"publisherRelationship":244,"citationCount":20,"citationInfo":20,"publishDate":271,"publishYear":272,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":20,"isForceReanalyzing":181},"22add8d5-fcf7-4ea4-a2c4-39da4662743e","2023-12-28T18:38:03.989+00:00","2025-01-26T23:53:04.546+00:00",[],"In-vitro-free-radical-scavenging-and-antidiabetic-activity-of-aqueous-and-ethanolic-leaf-extracts-a-comparative-evaluation-of-Argyreia-pierreana-and-Matelea-denticulata",{"references":189,"abstract":191,"title":193,"doi":195},{"VOID":190},"Tilburt JC, Kaptchuk TJ (2008) Herbal medicine research and global health: an ethical analysis. Bull World Health Organization 86(8):594–599\nBodeker C, Bodeker G, Ong C.K, Grundy C.K, Burford G, Shein K (2005) WHO global atlas of traditional, complementary and alternative medicine, Geneva, Switzerland.\nBordeker G (2002) Medicinal plants-towards sustainability and securityA paper prepared for IDRC medicinal plants global network. IDRC, South Asia Regional Office, New Delhi, India\nAslam MS, Ahmad MS (2016) Worldwide importance of medicinal plants: Current and historical perspectives. Recent Adv Biol Med 88(2):88–93\nAkram M, Nawaz A (2017) Effects of medicinal plants on Alzheimer’s disease and memory deficits. Neural Regen Res 12(4):660–670\nJivad N, Rabiei Z (2014) A review study on medicinal plants used in the treatment of learning and memory impairments. Asian Pac J Trop Biomed 10(4):780–789\nKumar RS, Rajkapoor B, Perumal P (2012) Antioxidant activities of Indigofera cassioides Rottl. Ex. DC. using various in vitro assay models. Asian. Pac J Trop Biomed 2(4):256–261\nVenkatachalam U, Muthukrishnan S (2012) Free radical scavenging activity of ethanolic extract of Desmodium gangeticum. J Acute Med 2(2):36–42\nCarocho M, Ferreira IC (2013) A review on antioxidants, prooxidants and related controversy: Natural and synthetic compounds, screening and analysis methodologies and future perspectives. Food Chem Toxicol 51:15–25\nSylvie DD, Anatole PC, Cabral BP, Veronique PB (2014) Comparison of in vitro antioxidant properties of extracts from three plants used for medical purpose in Cameroon: Acalypharacemosa, Garcinia lucida and Hymenocardia lyrate. Asian Pac J Trop Biomed 4(2):S625–S632\nCai Y, Luo Q, Sun M, Corke H (2004) Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci 74(17):2157–2184\nAkinmoladun AC, Obuotor EM, Farombi EO (2010) Evaluation of antioxidant and free radical scavenging capacities of some Nigerian indigenous medicinal plants. 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Indian J Nat Prod Resour 9(2):85–96\nStaples GW, Traiperm P, Chow J (2015) Another new Thai Argyreia species (Convolvulaceae). Phytotaxa 204(3):223–229\nBois MDGJ (1906) Argyreia pierreana Bois. Revue Horticole 78:560\nFang RC, Staples G (1995) Convolvulaceae. Flora China 16:271–325\nRoxburgh L, Choisy M (1995) Argyreia. Flora of China16:313-321.\nMcDonnell A (2014) Non-twining milkweed vines of oklahoma: an overview of Matelea biflora and Matelea cynanchoides (apocynaceae). Oklahoma Native Plant Record 14:67–79\nHarborne JB (1998) Phytochemical Methods: A guide to modern techniques of plant analysis, 3rd edn. Springer; Germany; ISBN 0412572605, 9780412572609\nKameswara Rao B, Renuka Sudarshan P, Rajasekhar MD, Nagaraju N, Appa Rao C (2003) Antidiabetic activity of Terminalia pallida fruit in alloxan induced diabetic rats. J. Ethnopharmacol 85(1):169–172\nKhandewal KR (2000) Practical Pharmacognosy Technique and experiments. 9th edn. Nirali Publications Pune 149-156.\nJin-Yuarn L, Ching-Yin T (2007) Determination of total phenolic and flavonoid contents in selected fruits and vegetables, as well as their stimulatory effects on mouse splenocyte proliferation. Food Chemistry 101:140–147\nBadami S, Gupta MK, Suresh B (2003) Antioxidant activity of the ethanolic extract of Striga orobanchioides. Journal of Ethnopharmacology 85:227–230\nWonyoung K, Heekyoung Y, Hyun JH, Chang HH, Young JL (2012) Anti-oxidant activities of kiwi fruit extract on carbon tetrachloride-induced liver injury in mice. Korean J Vet Res 52(4):270–280\nJaishree V, Shrishailappa B, Suresh B (2008) In vitro antioxidant activity of Enicostemma axillare J. Health Science 54(5):524–528\nNarasimharaju K, Nagarasanakote VT, Nagepally Venkataramareddy J, Ramaiah N, Sathyanarayana S, Bharat K (2015) Antifungal and antioxidant activities of organic and aqueous extracts of Annona squamosa Linn. leaves. J Food Drug Analysis 23:798–802\nFrancis D, Rita L (1986) Rapid colorometric assay for cell growth and survival modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 89(2):271–277\nTakigawa-Imamura H, Sekine T, Murata M, Takayama K, Nakazawa K, Nakagawa J (2003) Stimulation of glucose uptake in muscle cells by prolonged treatment with scriptide: a histone deacetylase inhibitor. Biosci Biotechnol Biochem 67(7):1499–1506\nKoivisto UM, Martinez-Valdez H, Bilan PJ, Burdett E, Ramlal T, Klip A (1991) Differential regulation of the GLUT1 and GLUT4 glucose transport systems by glucose and insulin in L6 muscle cells in culture. J Biol Chem 266(4):2615–2621\nIsakoff SJ, Taha C, Rose E, Marcuslon J, Klip A, Skolnik EY (1995) The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake. Proc Natl Acad Sci USA 92(22):10247–10251\nNeumann C, Yu A, Welge-Lüssen U, Lütjen-Drecoll E, Birke M (2008) The effect of TGF-beta2 on elastin, type VI collagen, and components of the proteolytic degradation system in human optic nerve astrocytes. Invest Ophthalmol Vis. Sci 49(4):1464–1472\nLobo V, Pati A, Phatak A, Chandra N (2010) Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev 4(8):118–126\nKunwar A, Priyadarsini KI (2011) Free radicals, oxidative stress and importance of antioxidants in human health. J Med Allied Sci 1(2):53–60\nKasote DM, Katyare SS, Hegde MV, Bae H (2015) Significance of antioxidant potential of plants and its relevance to therapeutic applications. Int J Biol Sci 11(8):982–991\nKaruna DS, Dey P, Das S, Kundu A, Bhakta T (2017) In vitro antioxidant activities of root extract of Asparagus racemosus Linn. J. Tradit Complement. Med 8(1):60–65\nPinto E, Sigaud-kutner T, Leitao MA, Okamoto OK, Morse D, Colepicolo P (2003) Heavy metal-induced oxidative stress in algae. J Phycol 39(6):1008–1018\nZhang YJ, Gan RY, Li S, Zhou Y, Li AN, Xu DP (2015) Antioxidant phytochemicals for the prevention and treatment of chronic diseases. Molecules 20(12):21138–21156\nPandey KB, Rizvi SI (2009) Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev 2(5):270–278\nMathew A, Abraham TE, Zakaria ZA (2015) Reactivity of phenolic compounds towards free radicals under in vitro conditions. J Food Sci Technol 52:5790–5798\nRavishankar M, Juliet Esther VC (2018) In vitro antioxidant activity of Hydrophila auriculata leaves extract and silver nanoparticles. J Nanosci Tech 4(5):549–551\nDe Oliveira AMF, Sousa Pinheiro L, Souto Pereira CK, Neves Matias W, Albuquerque Gomes R, Souza Chaves O (2012) Total phenolic content and antioxidant activity of some malvaceae family species. Antioxidants 1(1):33–43\nPiluzza G, Bullitta S (2011) Correlations between phenolic content and antioxidant properties in twenty-four plant species of traditional ethnoveterinary use in the Mediterranean area. Pharm Biol 49(3):240–247\nLiang T, Yue W, Li Q (2010) Comparison of the phenolic content and antioxidant activities of Apocynum venetum L. (Luo-Bu-Ma) and two of its alternative species. Int J Mol Sci 11(11):4452–4464\nGupta RN, Pareek A, Suthar M, Rathore GS, Basniwal PK, Jain D (2009) Study of glucose uptake activity of Helicteres isora Linn. fruits in L-6 cell lines. Int. J. Diabetes Dev. Ctries 29(4):170–173\nRajeswari R, Sriidevi M (2014) Study of in vitro glucose uptake activity of isolated compounds from hydro alcoholic leaf extract of Cardiospermum Halicacabum Linn. Int J Pharm Pharm Sci 6(11):181–185\nZhao P, Ming Q, Qiu J, Tian D, Liu J, Shen J (2018) Ethanolic extract of Folium Sennae mediates the glucose uptake of L6 cells by GLUT4 and Ca2+. Molecules 23(11):E2934\nKumar PM, Venkataranganna MV, Manjunath K, Viswanatha GL, Ashok A (2014) Methanolic extract of Momordica cymbalaria enhances glucose uptake in L6 myotubes in vitro by up-regulating PPAR-γ and GLUT-4. Chin J Nat Med 12(12):895–900",{"EN":192},"Oxidation is believed to play a vital role in the pathogenesis of diabetes mellitus by lipid peroxidation; DNA and protein damage leads to the development of vascular complications like coronary heart disease, stroke, neuropathy, retinopathy, and nephropathy. The herbal preparations are complementary and alternative medicines to allopathic drugs which are believed to cause adverse events. Therefore, the current study was aimed to identify the novel plants, which belong to the genera Argyreia (Argyreia pierreana (AP)) and Matelea (Matelea denticulata (MD)), and assess the aqueous and ethanolic leaf extracts for in vitro antioxidant and antidiabetic potential by DPPH, OH•, superoxide, and glucose uptake and gene expression (GLUT-4 and PPARγ) studies using the L-6 cell line respectively. The preliminary scrutiny revealed the presence of polyphenols, flavonoids, terpenoids, steroids, tannins, alkaloids, and glycosides. The total phenolic and flavonoid contents of ethanolic extracts were found higher than those of aqueous extracts. The ethanolic extracts exhibited the superior antioxidant capacity when compared with aqueous extracts. However, the ethanolic extract of MD was shown superlative glucose uptake activity (72.54%) over control (0.037%) and GLUT-4 and PPARγ gene expressions (1.17 and 1.20) in term of folds respectively over cell control (1.00). The ethanolic leaf extracts of both plants showed significant in vitro antioxidant and antidiabetic activities compare to aqueous extracts. The Matelea denticulata ethanolic leaf extract exhibited superior activity. This superior activity might be due to their higher phenolic and flavonoid content. However, further approaches are needed to define these activities.",{"EN":194},"In vitro free radical scavenging and antidiabetic activity of aqueous and ethanolic leaf extracts: a comparative evaluation of Argyreia pierreana and Matelea denticulata",{"VOID":196},"10.1186\u002Fs43094-019-0014-9","https:\u002F\u002Ffjps.springeropen.com\u002Farticles\u002F10.1186\u002Fs43094-019-0014-9",[199,214,229],{"id":200,"sortIndex":21,"researcher":20,"roles":201,"affiliations":202,"properties":211},"d4f717fb-1c51-4802-bf88-42dfef74d2e2",[121],[203],{"id":20,"sortIndex":21,"affiliation":204,"properties":20},{"id":205,"createTime":206,"updateTime":206,"relativeEntities":207,"slug":20,"properties":208,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"1517e672-0ff1-4a3e-8e42-c3da41ca226a","2023-12-28T18:38:04.002+00:00",[],{"title":209},{"VI":210},"Department of Pharmacology, SSJ College of Pharmacy, Hyderabad, India",{"title":212},{"VI":213},"Venkataiah Gudise",{"id":215,"sortIndex":85,"researcher":20,"roles":216,"affiliations":217,"properties":226},"faadfd7f-3836-4834-b372-aac44a88c042",[121],[218],{"id":20,"sortIndex":21,"affiliation":219,"properties":20},{"id":220,"createTime":221,"updateTime":221,"relativeEntities":222,"slug":20,"properties":223,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"de7808c7-20c9-4ded-bf25-63ed08cec596","2023-12-28T18:38:04.053+00:00",[],{"title":224},{"VI":225},"Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Kodoli, India",{"title":227},{"VI":228},"Arehalli S. Manjappa",{"id":230,"sortIndex":137,"researcher":20,"roles":231,"affiliations":232,"properties":241},"f919177e-4a56-4477-844e-f568078b62b4",[121],[233],{"id":20,"sortIndex":21,"affiliation":234,"properties":20},{"id":235,"createTime":236,"updateTime":236,"relativeEntities":237,"slug":20,"properties":238,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"3974708d-0095-41d9-838f-5d9959b4a5d0","2024-02-02T05:45:37.449+00:00",[],{"title":239},{"VI":240},"Department of Pharmacology, Roland Institute of Pharmaceutical Sciences, Berhampur, India",{"title":242},{"VI":243},"Bimalendu Chowdhury",{"url":197,"publisher":245,"properties":266},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":246,"slug":10,"properties":247,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":251,"manageAffiliations":252,"indexDatabases":253,"url":20,"thumbnailPath":20,"statistic":261,"gsStatistic":20,"type":92,"analyzePriority":20},[],{"issn":248,"title":249,"url":250},{"VOID":13},{"EN":15},{"VOID":17},[],[],[254],{"id":44,"indexDatabase":255,"url":59,"indexYears":20,"academicFieldIds":260,"indexDatabaseRanking":20},{"id":46,"createTime":47,"updateTime":48,"relativeEntities":256,"label":257,"description":258,"key":55,"publicationTags":259,"standard":20},[],{"EN":51,"VI":51},{"VI":53,"EN":54},[57,58],[61],{"impactFactor":21,"impactFactorByYear":262,"i10Index":68,"i10IndexLast5Year":69,"totalPublication":70,"totalPublicationByYear":263,"totalCitation":80,"totalCitationByYear":264,"totalCitationPerPublication":86,"totalCitationPerPublicationByYear":265,"hindexLast5Year":68,"hindex":68},{"2020":64,"2021":65,"2022":66,"2023":67},{"2015":72,"2016":72,"2017":69,"2018":73,"2019":74,"2020":75,"2021":76,"2022":77,"2023":78,"2024":79},{"2019":82,"2020":83,"2021":84,"2022":85},{"2019":88,"2020":89,"2021":90,"2022":91},{"volume":267,"pages":269},{"VOID":268},"5",{"VOID":270},"1-11","2019-12-19",2019,{"id":274,"createTime":275,"updateTime":276,"relativeEntities":277,"slug":278,"properties":279,"entityType":112,"verifyStatus":113,"verifyTime":276,"verifyNote":115,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":284,"fullTextUrl":20,"authors":285,"publicationType":151,"publisherRelationship":316,"citationCount":20,"citationInfo":20,"publishDate":343,"publishYear":344,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":20,"isForceReanalyzing":181},"11706f20-c182-4280-9622-2aca2964a349","2024-01-27T23:59:22.933+00:00","2025-01-05T23:49:28.416+00:00",[],"Development-and-validation-of-stability-indicating-HPLC-method-for-simeltaneous-determination-of-Lamivudine-Tenofovir-and-Dolutegravir-in-bulk-and-their-tablet-dosage-form",{"title":280,"doi":282},{"EN":281},"Development and validation of stability-indicating HPLC method for simeltaneous determination of Lamivudine, Tenofovir, and Dolutegravir in bulk and their tablet dosage form",{"VOID":283},"10.1016\u002Fj.fjps.2015.11.002","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS2314724515300182",[286,301],{"id":287,"sortIndex":21,"researcher":20,"roles":288,"affiliations":289,"properties":298},"63b8ab7d-565f-424e-bd10-d72493a91ec8",[121],[290],{"id":20,"sortIndex":21,"affiliation":291,"properties":20},{"id":292,"createTime":293,"updateTime":293,"relativeEntities":294,"slug":20,"properties":295,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"4156244a-a4ff-4eb4-8e0f-e40b1f29d213","2024-01-27T23:59:22.944+00:00",[],{"title":296},{"VI":297},"Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, India",{"title":299},{"VI":300},"Nagasarapu Mallikarjuna Rao",{"id":302,"sortIndex":137,"researcher":20,"roles":303,"affiliations":304,"properties":313},"a945bf66-4395-4056-af50-ce7ba376a862",[121],[305],{"id":20,"sortIndex":21,"affiliation":306,"properties":20},{"id":307,"createTime":308,"updateTime":308,"relativeEntities":309,"slug":20,"properties":310,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"9e083b23-aa33-4f09-a656-420db0db4e61","2024-01-27T23:59:22.957+00:00",[],{"title":311},{"VI":312},"Department of Pharmaceutical Analysis & Quality Assurance, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India",{"title":314},{"VI":315},"Dannana Gowri Sankar",{"url":284,"publisher":317,"properties":338},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":318,"slug":10,"properties":319,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":323,"manageAffiliations":324,"indexDatabases":325,"url":20,"thumbnailPath":20,"statistic":333,"gsStatistic":20,"type":92,"analyzePriority":20},[],{"issn":320,"title":321,"url":322},{"VOID":13},{"EN":15},{"VOID":17},[],[],[326],{"id":44,"indexDatabase":327,"url":59,"indexYears":20,"academicFieldIds":332,"indexDatabaseRanking":20},{"id":46,"createTime":47,"updateTime":48,"relativeEntities":328,"label":329,"description":330,"key":55,"publicationTags":331,"standard":20},[],{"EN":51,"VI":51},{"VI":53,"EN":54},[57,58],[61],{"impactFactor":21,"impactFactorByYear":334,"i10Index":68,"i10IndexLast5Year":69,"totalPublication":70,"totalPublicationByYear":335,"totalCitation":80,"totalCitationByYear":336,"totalCitationPerPublication":86,"totalCitationPerPublicationByYear":337,"hindexLast5Year":68,"hindex":68},{"2020":64,"2021":65,"2022":66,"2023":67},{"2015":72,"2016":72,"2017":69,"2018":73,"2019":74,"2020":75,"2021":76,"2022":77,"2023":78,"2024":79},{"2019":82,"2020":83,"2021":84,"2022":85},{"2019":88,"2020":89,"2021":90,"2022":91},{"volume":339,"pages":341},{"VOID":340},"1",{"VOID":342},"73-77","2015-12-01",2015,{"id":346,"createTime":347,"updateTime":348,"relativeEntities":349,"slug":350,"properties":351,"entityType":112,"verifyStatus":113,"verifyTime":348,"verifyNote":115,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":360,"fullTextUrl":20,"authors":361,"publicationType":151,"publisherRelationship":389,"citationCount":20,"citationInfo":20,"publishDate":414,"publishYear":180,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":20,"isForceReanalyzing":181},"1381ce60-cde8-4bc9-9cc0-12d64e29afa5","2024-01-16T22:05:59.141+00:00","2025-01-16T23:46:58.981+00:00",[],"A-review-on-phytoconstituents-of-marine-brown-algae",{"references":352,"abstract":354,"title":356,"doi":358},{"VOID":353},"Kolanjinathan K, Ganesh P, Saranraj P (2014) Pharmacological importance of seaweeds: a review. World J Fish Marine Sci 6(1):01–15. https:\u002F\u002Fdoi.org\u002F10.5829\u002Fidosi.wjfms.2014.06.01.76195\nDawczynski C, Schubert R, Jahreis G (2007) Amino acids, fatty acids, and dietary fibre in edible seaweed products. Food Chem 103:891–899. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.foodchem.2006.09.041\nFleurence J (1999) Seaweed proteins: biochemical, nutritional aspects and potential uses. Trends Food Sci Technol 10:25–28. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0924-2244(99)00015-1\nAnantharaman P (2002) Manual on identification of seaweed. All India coordinate project on survey and Inventorization of coastal and marine biodiversity. J Mar Biol Assoc India 29:1–9\nDang TT, Michael CB, Ian A, Christopher JS (2018) Comparison of chemical profile and antioxidant properties of the brown algae. Int J Food Sci Technol 53:174–181. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fijfs.13571\nGupta S, Abu-Ghannam N (2011) Bioactive potential and possible health effects of edible brown seaweeds. Trends Food Sci Technol 22:315–326. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.tifs.2011.03.011\nSanchez-Machado DI, López-Cervantes J, López-Hernández J, Paseiro-Losada P (2004) An HPLC method for the quantification of sterols in edible seaweeds. Biomed Chromatogr 18:183–190. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fbmc.316\nWhittaker MH, Frankos VH, Wolterbeek AMP, Waalkens-Berendsen DH (2000) Effects of dietary phytosterols on cholesterol metabolism and atherosclerosis: clinical and experimental evidence. Am J Med 109:600–601. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0002-9343(00)00588-X\nPal A, Kamthania MC, Kumar A (2014) Bioactive compounds and properties of seaweeds- a review. OA Lib J 1:752. https:\u002F\u002Fdoi.org\u002F10.4236\u002Foalib.1100752\nWijesinghea JP, You JP (2012) Biological activities and potential industrial applications of fucose rich sulfated polysaccharides and fucoidans isolated from brown seaweeds: a review. Carbohydr Polym 88:13–20. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.carbpol.2011.12.029\nBlunt JW, Copp BR, Munro MHG, Northcote PT, Prinsep MR (2018) Marine natural products. Nat Prod Rep 23:26–78. https:\u002F\u002Fdoi.org\u002F10.1039\u002Fc3np70117d\nPaula JC, Pedrini AG, Pinheiro MD, Pereira RC, Teixeira VL (2001) Chemical similarity between the brown algae Dictyota cervicornis and D. pardalis (Dictyotales, Phaeophyta). Biochem Syst Ecol 29:425–427. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0305-1978(00)00066-1 PMID: 11182491\nCox S, Gupta S, Abu-Ghannam N (2012) Effect of different rehydration temperatures on the moisture, content of phenolic compounds, antioxidant capacity and textural properties of edible Irish brown seaweed. LWT-Food Sci Technol 47:300–307. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.lwt.2012.01.023\nChakaborty K, Joseph D, Praveen NK (2015) Antioxidant activities and phenolic contents of three red seaweeds (division: Rhodophyta) harvested from the Gulf of Mannar of peninsular India. J Food Sci Technol 52:1924–1935. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs13197-013-1189-2 PMID: 25829573\nDixit DC, Reddy CRK, Balar N, Suthar P, Gajaria T, Gadhavi DK (2018) Assessment of the nutritive, biochemical, antioxidant and antibacterial potential of eight tropical macro algae along Kachchh coast, India as human food supplements. J Aquat Food Prod T 27:61–79. https:\u002F\u002Fdoi.org\u002F10.1080\u002F10498850.2017.1396274\nCumashi A, Ushakova NA, Preobrazhenskaya ME, D’Incecco A, Piccoli A, Totani L (2007) A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds. Glycobiology 17:541–552. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fglycob\u002Fcwm014 PMID: 17296677\nDurig J, Bruhn T, Zurborn KH, Gutensohn K, Bruhn HD, Béress L (1997) Anticoagulant fucoidan fractions from Fucus vesiculosus induce platelet activation in vitro. Thromb Res 85:79–491. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0049-3848(97)00037-6\nGeneralić Mekinić I, Skroza D, Šimat V, Hamed I, Čagalj M, Popović Perković Z (2019) Phenolic content of brown algae (Pheophyceae) species: extraction, identification, and quantification. 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Fish Aquatic Sci 19:1–6. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs41240-016-0003-2\nKoivikko R, Loponen J, Pihlaja K, Jormalainen V (2007) High-performance liquid chromatographic analysis of phlorotannins from the brown alga Fucus vesiculosus. Phytochem Anal 18:326–332. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fpca.986 PMID: 17623367\nSaravana PS, Getachew AT, Cho YJ, Choi JH, Park YB, Woo HC, Chun BS (2017) Influence of co-solvents on fucoxanthin and phlorotannin recovery from brown seaweed using supercritical CO2. J Supercrit Fluids 120:295–303. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.supflu.2016.05.037\nSanchezCamargo AP, Montero L, Cifuentes A, Herrero M, Ibáñez E (2016) Application of Hansen solubility approach for the subcritical and supercritical selective extraction of phlorotannins from Cystoseira abies-marina. 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Fisheries Sci 72:1292–1299. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1444-2906.2006.01288.x\nJoe MJ, Kim SN, Choi HY, Shin WS, Park GM, Kang DW, Kim YK (2006) The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts. Biol Pharm Bull 29:1735–1739. https:\u002F\u002Fdoi.org\u002F10.1248\u002Fbpb.29.1735 PMID: 16880634\nSugiura Y, Matsuda K, Yamada Y, Nishikawa M, Shoiya K, Katsuzaki H, Imai K, Amano H (2006) Isolation of a new anti-allergic phlorotannin, phlorofucofuroeckol-b, from an edible brown alga Eisenia arborea. Biosci. Biotechnol. Biochem 70(11):2807–2811. https:\u002F\u002Fdoi.org\u002F10.1271\u002Fbbb.60417\nKoch M, Gregson RP (1984) Brominated phlorethols and nonhalogenated phlorotannins from the brown alga Cystophora congesta. 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Future J Pharmaceutical Sci 6(1):1–14. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs43094-020-00039-9",{"EN":355},"From the last few years, the development and discovery of bioactive compounds and their potential properties from marine algae have been enhanced significantly. The coastal area is a huge storehouse for propitious algae. It has been the genuine reality that the consequence of marine algae as a source of different compounds is increasing. Numerous advanced research devices are available for the discovery of synthetic compounds but still many researchers are working on natural bioactive compounds to discover their biological properties, which are useful to society. Marine algae are taking the preponderance of consideration from investigators owing to its phenomenon of biological activity like anti-cancer, anti-viral, cholesterol-reducing, and many more. A variety of compounds are collected from algae with specific purposes as they remain in an extremely ambitious and hard state; this condition is responsible for the synthesis of very particularly effective bioactive compounds. The present article is concentrating on the brown algae of the Gujarat coast, phlorotannins, polyphenol, phytosterol from brown algae, and their various applications. The main importance has been given to the secondary metabolites and various applications of marine brown algae. From this review, it can be concluded that the prominent bioactive compounds from brown algae can cure many serious diseases. Besides, the potential biological activities of a special bioactive compound may represent the interest in the industry of pharmaceuticals, cosmeceutical, and functional foods.",{"EN":357},"A review on phytoconstituents of marine brown algae",{"VOID":359},"10.1186\u002Fs43094-020-00147-6","https:\u002F\u002Ffjps.springeropen.com\u002Farticles\u002F10.1186\u002Fs43094-020-00147-6",[362,377],{"id":363,"sortIndex":21,"researcher":20,"roles":364,"affiliations":365,"properties":374},"13867e6f-87b5-44b1-820c-c96f1f0fa87f",[121],[366],{"id":20,"sortIndex":21,"affiliation":367,"properties":20},{"id":368,"createTime":369,"updateTime":369,"relativeEntities":370,"slug":20,"properties":371,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"0f049483-f737-4475-9a15-22e545d3280a","2023-12-07T18:28:33.004+00:00",[],{"title":372},{"VI":373},"Department of Life Sciences, Hemchandracharya North Gujarat University, Patan, India",{"title":375},{"VI":376},"Masuma M. Hakim",{"id":378,"sortIndex":137,"researcher":20,"roles":379,"affiliations":380,"properties":386},"8280b4b9-e42a-4dd6-b676-739f7d1f0067",[121],[381],{"id":20,"sortIndex":21,"affiliation":382,"properties":20},{"id":368,"createTime":369,"updateTime":369,"relativeEntities":383,"slug":20,"properties":384,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":385},{"VI":373},{"title":387},{"VI":388},"Illa C. Patel",{"url":360,"publisher":390,"properties":411},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":391,"slug":10,"properties":392,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":396,"manageAffiliations":397,"indexDatabases":398,"url":20,"thumbnailPath":20,"statistic":406,"gsStatistic":20,"type":92,"analyzePriority":20},[],{"issn":393,"title":394,"url":395},{"VOID":13},{"EN":15},{"VOID":17},[],[],[399],{"id":44,"indexDatabase":400,"url":59,"indexYears":20,"academicFieldIds":405,"indexDatabaseRanking":20},{"id":46,"createTime":47,"updateTime":48,"relativeEntities":401,"label":402,"description":403,"key":55,"publicationTags":404,"standard":20},[],{"EN":51,"VI":51},{"VI":53,"EN":54},[57,58],[61],{"impactFactor":21,"impactFactorByYear":407,"i10Index":68,"i10IndexLast5Year":69,"totalPublication":70,"totalPublicationByYear":408,"totalCitation":80,"totalCitationByYear":409,"totalCitationPerPublication":86,"totalCitationPerPublicationByYear":410,"hindexLast5Year":68,"hindex":68},{"2020":64,"2021":65,"2022":66,"2023":67},{"2015":72,"2016":72,"2017":69,"2018":73,"2019":74,"2020":75,"2021":76,"2022":77,"2023":78,"2024":79},{"2019":82,"2020":83,"2021":84,"2022":85},{"2019":88,"2020":89,"2021":90,"2022":91},{"volume":412,"pages":413},{"VOID":176},{"VOID":270},"2020-12-09",{"id":416,"createTime":417,"updateTime":418,"relativeEntities":419,"slug":420,"properties":421,"entityType":112,"verifyStatus":113,"verifyTime":434,"verifyNote":115,"syncStatus":19,"languages":20,"translateLanguages":435,"viewCount":21,"primaryUrl":437,"fullTextUrl":20,"authors":438,"publicationType":151,"publisherRelationship":545,"citationCount":20,"citationInfo":20,"publishDate":572,"publishYear":573,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":20,"isForceReanalyzing":181},"57e77848-5062-4830-9b47-fc03039f1e2c","2024-01-29T12:17:16.407+00:00","2025-01-20T23:46:24.413+00:00",[],"Insights-on-recent-approaches-in-drug-discovery-strategies-and-untapped-drug-targets-against-drug-resistance",{"references":422,"abstract":424,"title":427,"doi":430,"keywords":432},{"VOID":423},"Gerard D (2016) Antibiotic adjuvants: rescuing antibiotics from resistance. 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Biochem J 386:127–135\nIzard TA (2002) The crystal structures of phosphopantetheineadenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism. J Mol Biol 315:487–495\nIzard TA (2003) Novel adenylate binding site confers phosphopantetheineadenylyltransferase interactions with Coenzyme. J Bacteriol 185:4074–4080\nMarko Juki C, Stanislav G, Matej S (2019) Reaching toward underexplored targets in antibacterial. Drug Dev Res 80:6–10\nElif T, Cynthia W, Tina MK, Singh N, Mauricio CL, Robert D, Van MS, Pamela JY (2018) Prevalence and patterns of higher-order drug interactions in Escherichia coli. npj Syst Biol Appl 4:31",{"EN":425,"VI":426},"Despite the various strategies undertaken in the clinical practice, the mortality rate due to antibiotic-resistant microbes has been markedly increasing worldwide. In addition to multidrug-resistant (MDR) microbes, the “ESKAPE” bacteria are also emerging. Of course, the infection caused by ESKAPE cannot be treated even with lethal doses of antibiotics. Now, the drug resistance is also more prevalent in antiviral, anticancer, antimalarial and antifungal chemotherapies. To date, in the literature, the quantum of research reported on the discovery strategies for new antibiotics is remarkable but the milestone is still far away. Considering the need of the updated strategies and drug discovery approaches in the area of drug resistance among researchers, in this communication, we consolidated the insights pertaining to new drug development against drug-resistant microbes. It includes drug discovery void, gene paradox, transposon mutagenesis, vitamin biosynthesis inhibition, use of non-conventional media, host model, target through quorum sensing, genomic-chemical network, synthetic viability to targets, chemical versus biological space, combinational approach, photosensitization, antimicrobial peptides and transcriptome profiling. Furthermore, we optimally briefed about antievolution drugs, nanotheranostics and antimicrobial adjuvants and then followed by twelve selected new feasible drug targets for new drug design against drug resistance. Finally, we have also tabulated the chemical structures of potent molecules against antimicrobial resistance. It is highly recommended to execute the anti-drug resistance research as integrated approach where both molecular and genetic research needs to be as integrative objective of drug discovery. This is time to accelerate new drug discovery research with advanced genetic approaches instead of conventional blind screening.","Mặc dù đã có nhiều chiến lược được thực hiện trong thực hành lâm sàng, tỷ lệ tử vong do vi khuẩn kháng kháng sinh đã tăng đáng kể trên toàn cầu. Bên cạnh vi khuẩn kháng đa thuốc (MDR), các chủng vi khuẩn “ESKAPE” cũng đang nổi lên. Dĩ nhiên, nhiễm trùng do ESKAPE gây ra không thể được điều trị ngay cả với các liều kháng sinh cao nhất. Hiện nay, tình trạng kháng thuốc cũng đang gia tăng trong các liệu pháp kháng virus, hóa trị liệu chống ung thư, chống sốt rét và chống nấm. Tính đến nay, trong tài liệu hiện có, lượng nghiên cứu được báo cáo về các chiến lược khám phá kháng sinh mới là rất đáng kể nhưng cột mốc này vẫn còn xa vời. Cân nhắc đến nhu cầu về các chiến lược cập nhật và phương pháp khám phá thuốc trong lĩnh vực kháng thuốc trong giới nghiên cứu, trong bài viết này, chúng tôi đã tập hợp những hiểu biết liên quan đến phát triển thuốc mới chống lại các vi khuẩn kháng thuốc. Điều này bao gồm khoảng trống trong việc khám phá thuốc, nghịch lý gen, đột biến do transposon, ức chế tổng hợp vitamin, sử dụng môi trường không truyền thống, mô hình chủ, mục tiêu thông qua cảm nhận quần thể, mạng lưới hóa học-gen, khả năng tổng hợp nhắm đến mục tiêu, không gian hóa học so với sinh học, phương pháp kết hợp, quang cảm ứng, peptide kháng khuẩn và phân tích transcriptome. Hơn nữa, chúng tôi đã tóm tắt một cách tối ưu về các loại thuốc chống tiến hóa, nanotheranostics và phụ gia kháng khuẩn, sau đó là mười hai mục tiêu thuốc mới khả thi cho thiết kế thuốc mới chống lại tình trạng kháng thuốc. Cuối cùng, chúng tôi cũng đã tổng hợp cấu trúc hóa học của các phân tử tiềm năng chống lại kháng thuốc kháng khuẩn. Rất khuyến khích việc thực hiện nghiên cứu chống kháng thuốc như một phương pháp tiếp cận tích hợp, nơi nghiên cứu cả về phân tử và di truyền cần được coi là mục tiêu tích hợp trong việc khám phá thuốc. Đây là thời điểm để tăng tốc nghiên cứu khám phá thuốc mới với các phương pháp di truyền tiên tiến thay vì sàng lọc mù theo cách thông thường.",{"EN":428,"VI":429},"Insights on recent approaches in drug discovery strategies and untapped drug targets against drug resistance","Những hiểu biết về các phương pháp gần đây trong chiến lược khám phá thuốc và các mục tiêu thuốc chưa được khai thác chống lại tình trạng kháng thuốc",{"VOID":431},"10.1186\u002Fs43094-021-00196-5",{"VI":433},"","2025-01-14T12:52:08.997+00:00",[436],"VI","https:\u002F\u002Ffjps.springeropen.com\u002Farticles\u002F10.1186\u002Fs43094-021-00196-5",[439,455,467,479,491,506,519,532],{"id":440,"sortIndex":441,"researcher":20,"roles":442,"affiliations":443,"properties":452},"57aa1b62-4092-4f48-98b1-4ed76e25bef6",4,[121],[444],{"id":20,"sortIndex":21,"affiliation":445,"properties":20},{"id":446,"createTime":447,"updateTime":447,"relativeEntities":448,"slug":20,"properties":449,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"93bb8454-ffdd-4968-8696-0c3a41b60c9a","2024-01-29T12:17:16.527+00:00",[],{"title":450},{"VI":451},"RERDS-CPR, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Anantapur, India",{"title":453},{"VI":454},"Padmanabha Reddy Yiragamreddy",{"id":456,"sortIndex":21,"researcher":20,"roles":457,"affiliations":458,"properties":464},"f0e6eebf-f06d-43de-9970-cca771d061ac",[121],[459],{"id":20,"sortIndex":21,"affiliation":460,"properties":20},{"id":446,"createTime":447,"updateTime":447,"relativeEntities":461,"slug":20,"properties":462,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":463},{"VI":451},{"title":465},{"VI":466},"Ramalingam Peraman",{"id":468,"sortIndex":137,"researcher":20,"roles":469,"affiliations":470,"properties":476},"0165a081-f87b-40d5-9224-265f9cee7ee6",[121],[471],{"id":20,"sortIndex":21,"affiliation":472,"properties":20},{"id":446,"createTime":447,"updateTime":447,"relativeEntities":473,"slug":20,"properties":474,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":475},{"VI":451},{"title":477},{"VI":478},"Sathish Kumar Sure",{"id":480,"sortIndex":72,"researcher":20,"roles":481,"affiliations":482,"properties":488},"229483ba-b0b2-450d-a97c-964d8cc3f09a",[121],[483],{"id":20,"sortIndex":21,"affiliation":484,"properties":20},{"id":446,"createTime":447,"updateTime":447,"relativeEntities":485,"slug":20,"properties":486,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":487},{"VI":451},{"title":489},{"VI":490},"Vinay Kumar Kutagulla",{"id":492,"sortIndex":85,"researcher":20,"roles":493,"affiliations":494,"properties":503},"54f253b2-f7c3-4b46-b0ec-75a6fb96a65b",[121],[495],{"id":20,"sortIndex":21,"affiliation":496,"properties":20},{"id":497,"createTime":498,"updateTime":498,"relativeEntities":499,"slug":20,"properties":500,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"d9e3ba70-288f-43a3-8a4d-c5e841ab1952","2024-01-29T12:17:16.462+00:00",[],{"title":501},{"VI":502},"ICMR-National Institute of Research in Tuberculosis, Chennai, India",{"title":504},{"VI":505},"V. N. Azger Dusthackeer",{"id":507,"sortIndex":508,"researcher":20,"roles":509,"affiliations":510,"properties":516},"275cb897-b314-45e7-9b4a-b7c3911f163e",3,[121],[511],{"id":20,"sortIndex":21,"affiliation":512,"properties":20},{"id":446,"createTime":447,"updateTime":447,"relativeEntities":513,"slug":20,"properties":514,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":515},{"VI":451},{"title":517},{"VI":518},"Naresh Babu Chilamakuru",{"id":520,"sortIndex":521,"researcher":20,"roles":522,"affiliations":523,"properties":529},"bf5cfcdf-e58c-4884-8cb5-87c628292e16",7,[121],[524],{"id":20,"sortIndex":21,"affiliation":525,"properties":20},{"id":446,"createTime":447,"updateTime":447,"relativeEntities":526,"slug":20,"properties":527,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":528},{"VI":451},{"title":530},{"VI":531},"Santhivardhan Chinni",{"id":533,"sortIndex":534,"researcher":20,"roles":535,"affiliations":536,"properties":542},"a1ea3a8c-d6c1-4368-b815-39103d45b7af",5,[121],[537],{"id":20,"sortIndex":21,"affiliation":538,"properties":20},{"id":446,"createTime":447,"updateTime":447,"relativeEntities":539,"slug":20,"properties":540,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":541},{"VI":451},{"title":543},{"VI":544},"Chiranjeevi Pokuri",{"url":437,"publisher":546,"properties":567},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":547,"slug":10,"properties":548,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":552,"manageAffiliations":553,"indexDatabases":554,"url":20,"thumbnailPath":20,"statistic":562,"gsStatistic":20,"type":92,"analyzePriority":20},[],{"issn":549,"title":550,"url":551},{"VOID":13},{"EN":15},{"VOID":17},[],[],[555],{"id":44,"indexDatabase":556,"url":59,"indexYears":20,"academicFieldIds":561,"indexDatabaseRanking":20},{"id":46,"createTime":47,"updateTime":48,"relativeEntities":557,"label":558,"description":559,"key":55,"publicationTags":560,"standard":20},[],{"EN":51,"VI":51},{"VI":53,"EN":54},[57,58],[61],{"impactFactor":21,"impactFactorByYear":563,"i10Index":68,"i10IndexLast5Year":69,"totalPublication":70,"totalPublicationByYear":564,"totalCitation":80,"totalCitationByYear":565,"totalCitationPerPublication":86,"totalCitationPerPublicationByYear":566,"hindexLast5Year":68,"hindex":68},{"2020":64,"2021":65,"2022":66,"2023":67},{"2015":72,"2016":72,"2017":69,"2018":73,"2019":74,"2020":75,"2021":76,"2022":77,"2023":78,"2024":79},{"2019":82,"2020":83,"2021":84,"2022":85},{"2019":88,"2020":89,"2021":90,"2022":91},{"volume":568,"pages":570},{"VOID":569},"7",{"VOID":571},"1-25","2021-03-03",2021,{"id":575,"createTime":576,"updateTime":577,"relativeEntities":578,"slug":579,"properties":580,"entityType":112,"verifyStatus":113,"verifyTime":577,"verifyNote":115,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":589,"fullTextUrl":20,"authors":590,"publicationType":151,"publisherRelationship":633,"citationCount":20,"citationInfo":20,"publishDate":658,"publishYear":573,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":20,"isForceReanalyzing":181},"893628fe-15f1-4297-a35c-00a638b5136d","2023-12-14T03:14:56.870+00:00","2025-01-27T23:42:51.702+00:00",[],"A-novel-LC-MS-method-development-and-validation-for-the-determination-of-phenyl-vinyl-sulfone-in-eletriptan-hydrobromide",{"references":581,"abstract":583,"title":585,"doi":587},{"VOID":582},"Derry S, Moore RA, Mcquay HJ (2010) Eletriptan for acute migraine headaches in adults. Cochrane Database Syst Rev 4\nSandrini G, Perrotta A, Nappi G (2006) Eletriptan: a review and new perspectives. Expert Rev Neurother 6:1413–1421\nTakiya L, Piccininni LC, Kamath V (2006) Safety and efficacy of eletriptan in the treatment of acute migraine. Pharmacother J Hum Pharmacol Drug Ther 26:115–128\nPubchem, Eletriptan. Https:\u002F\u002FPubchem.Ncbi.Nlm.Nih.Gov\u002FCompound\u002F77993 (Accessed 24 Apr 2020).\nPubchem, Phenyl vinyl sulfone. Https:\u002F\u002FPubchem.Ncbi.Nlm.Nih.Gov\u002FCompound\u002F79664 (Accessed 24 Apr 2020).\nMadasu SB, Vekariya NA, Kiran MN, Gupta B, Islam A, Douglas PS, Babu KR (2012) Synthesis of compounds related to the anti-migraine drug eletriptan hydrobromide. Beilstein J Org Chem 8:1400–1405\nQ3a(R) Impurities in new drug substances, FDA. Https:\u002F\u002FWww.Fda.Gov\u002FRegulatory-Information\u002FSearch-Fda-Guidance-Documents\u002FQ3ar-Impurities-New-Drug-Substances (Accessed 25 Apr 2020).\nSingh PK, Dinda SC (2013) Development and validation of a stability indicating RP-HPLC method for determination of eletriptan in eletriptan hydrobromide orally disintegrating tablets. Int Res J Pharm 4:179–182\nJocić B, Zečević M, Živanović L, Protić A, Jadranin M, Vajs V (2009) Study of forced degradation behavior of eletriptan hydrobromide by LC and LC–MS and development of stability-indicating method. J Pharm Biomed Anal 50:622–629\nRao PVSRM, Babu RK, Murthy CHVR, Acharyulu MLN (2016) Analytical application of E.B.T in spectrophotometric determination of eletriptan hydrobromide. Innovare J Sci 5:538–540\nRambabu CH, Venugopal V, Ramu G, Bikshan A (2012) An isocratic reverse phase HPLC method development for the determination of eletriptan hydrobromide in pure and pharmaceutical formulations. Int J Pharm Tech.Res 4:1504–1507",{"EN":584},"The aim of the present method is to develop and validate a specific, sensitive, precise, and accurate liquid chromatography-mass spectrometry (LC-MS) method for the estimation of the phenyl vinyl sulfone in the eletriptan hydrobromide. The effective separation of the phenyl vinyl sulfone was achieved by the Symmetry C18 (50 × 4.6 mm, 3.5 μm) column and a mobile phase composition of 0.1%v\u002Fv ammonia buffer to methanol (5:95 v\u002Fv), using 0.45 ml\u002Fmin flow rate and 20 μl of injection volume, with methanol used as diluent. The phenyl vinyl sulfone was monitored on atomic pressure chemical ionization mode mass spectrometer with positive polarity mode. The retention time of phenyl vinyl sulfone was found at 2.13 min. The limit of detection (LOD) and limit of quantification (LOQ) were observed at 1.43 ppm and 4.77 ppm concentration respectively; the linear range was found in the concentration ranges from 4.77 to 27.00 ppm with regression coefficient of 0.9990 and accuracy in the range of 97.50–102.10%. The percentage relative standard deviation (% RSD) for six replicates said to be injections were less than 10%. The proposed method was validated successfully as per ICH guidelines. Hence, this is employed for the determination of phenyl vinyl sulfone in the eletriptan hydrobromide.",{"EN":586},"A novel LC-MS method development and validation for the determination of phenyl vinyl sulfone in eletriptan hydrobromide",{"VOID":588},"10.1186\u002Fs43094-020-00175-2","https:\u002F\u002Ffjps.springeropen.com\u002Farticles\u002F10.1186\u002Fs43094-020-00175-2",[591,606,618],{"id":592,"sortIndex":85,"researcher":20,"roles":593,"affiliations":594,"properties":603},"16731751-6411-48c7-a75f-cf87adfea10f",[121],[595],{"id":20,"sortIndex":21,"affiliation":596,"properties":20},{"id":597,"createTime":598,"updateTime":598,"relativeEntities":599,"slug":20,"properties":600,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"56851dad-466b-4acc-8b88-4dbcca6c20f5","2023-12-14T03:14:56.894+00:00",[],{"title":601},{"VI":602},"Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Anantapur, India",{"title":604},{"VI":605},"N. Devanna",{"id":607,"sortIndex":21,"researcher":20,"roles":608,"affiliations":609,"properties":615},"6428c979-220e-4b5a-afc9-dfa9658ca60c",[121],[610],{"id":20,"sortIndex":21,"affiliation":611,"properties":20},{"id":597,"createTime":598,"updateTime":598,"relativeEntities":612,"slug":20,"properties":613,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":614},{"VI":602},{"title":616},{"VI":617},"Indhu Priya Mabbu",{"id":619,"sortIndex":137,"researcher":20,"roles":620,"affiliations":621,"properties":630},"a836c3e8-a26e-480c-a442-78109d765430",[121],[622],{"id":20,"sortIndex":21,"affiliation":623,"properties":20},{"id":624,"createTime":625,"updateTime":625,"relativeEntities":626,"slug":20,"properties":627,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"25330dc5-cce0-4b3c-bf50-b400850fda8a","2023-12-14T03:14:56.885+00:00",[],{"title":628},{"VI":629},"Department of Chemistry, Anantha Lakshmi Institute of Technology and Sciences, Anantapur, India",{"title":631},{"VI":632},"G. Sumathi",{"url":589,"publisher":634,"properties":655},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":635,"slug":10,"properties":636,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":640,"manageAffiliations":641,"indexDatabases":642,"url":20,"thumbnailPath":20,"statistic":650,"gsStatistic":20,"type":92,"analyzePriority":20},[],{"issn":637,"title":638,"url":639},{"VOID":13},{"EN":15},{"VOID":17},[],[],[643],{"id":44,"indexDatabase":644,"url":59,"indexYears":20,"academicFieldIds":649,"indexDatabaseRanking":20},{"id":46,"createTime":47,"updateTime":48,"relativeEntities":645,"label":646,"description":647,"key":55,"publicationTags":648,"standard":20},[],{"EN":51,"VI":51},{"VI":53,"EN":54},[57,58],[61],{"impactFactor":21,"impactFactorByYear":651,"i10Index":68,"i10IndexLast5Year":69,"totalPublication":70,"totalPublicationByYear":652,"totalCitation":80,"totalCitationByYear":653,"totalCitationPerPublication":86,"totalCitationPerPublicationByYear":654,"hindexLast5Year":68,"hindex":68},{"2020":64,"2021":65,"2022":66,"2023":67},{"2015":72,"2016":72,"2017":69,"2018":73,"2019":74,"2020":75,"2021":76,"2022":77,"2023":78,"2024":79},{"2019":82,"2020":83,"2021":84,"2022":85},{"2019":88,"2020":89,"2021":90,"2022":91},{"volume":656,"pages":657},{"VOID":569},{"VOID":178},"2021-01-14",{"id":660,"createTime":661,"updateTime":662,"relativeEntities":663,"slug":664,"properties":665,"entityType":112,"verifyStatus":113,"verifyTime":662,"verifyNote":115,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":674,"fullTextUrl":20,"authors":675,"publicationType":151,"publisherRelationship":751,"citationCount":20,"citationInfo":20,"publishDate":776,"publishYear":573,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":20,"isForceReanalyzing":181},"29229923-34a7-440d-8158-587af8763aa6","2024-01-16T09:24:05.392+00:00","2024-06-24T23:41:40.923+00:00",[],"Qualitative-and-quantitative-phytochemical-composition-antimicrobial-activity-and-brine-shrimp-cytotoxicity-of-different-solvent-extracts-of-Acanthus-polystachyus-Keetia-gueinzii-and-Rhynchosia-elegans",{"references":666,"abstract":668,"title":670,"doi":672},{"VOID":667},"Antimicrobial resistance. http:\u002F\u002Fwww.who.int\u002Fnews-room\u002Ffact-sheets\u002Fdetail\u002Fantimicrobial-resistance. Accessed 31 July 2021\nChalmers G, Cormier AC, Nadeau M, Côté G, Reid-Smith RJ, Boerlin P (2017) Determinants of virulence and of resistance to ceftiofur, gentamicin, and spectinomycin in clinical Escherichia coli from broiler chickens in Québec, Canada. Vet Microbiol 203:149–157\nAbd El Tawab AA, El-Hofy FI, El-Ekhnawy KI, El-Shora HE (2019) Detection of some virulence and resistance genes of S. aureus and B. cereus isolated from some meat products. Nat Sci 17:85–91. https:\u002F\u002Fdoi.org\u002F10.7537\u002Fmarsnsj170219.09\nFreire JCP, de Júnior JKO, de Silva DF, de Sousa JP, Guerra FQS, de Oliveira LE (2017) Antifungal activity of essential oils against Candida albicans strains isolated from users of dental prostheses. Evid Based Complement Altern Med. https:\u002F\u002Fdoi.org\u002F10.1155\u002F2017\u002F7158756\nRuhsam M, Hollingsworth PM (2018) Authentication of Eleutherococcus and Rhodiola herbal supplement products in the United Kingdom. J Pharm Biomed Anal 149:403–409. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jpba.2017.11.025\nWHO releases new International Classification of Diseases (ICD 11). http:\u002F\u002Fwww.who.int\u002Fnews-room\u002Fdetail\u002F18-06-2018-who-releases-new-international-classification-of-diseases-(icd-11). Accessed 1 May 2020\nSubramani R, Narayanasamy M, Feussner KD (2017) Plant-derived antimicrobials to fight against multi-drug-resistant human pathogens. 3 Biotech 7:1–15\nKhan S, Imran M, Imran M, Pindari N (2017) Antimicrobial activity of various ethanolic plant extracts against pathogenic multi drug resistant Candida spp. Bioinformation 13:67\nMulat M, Pandita A, Khan F (2019) Medicinal plant compounds for combating the multi-drug resistant pathogenic bacteria: a review. Curr Pharm Biotechnol 20:183–196\nGishen NZ, Taddese S, Zenebe T, Dires K, Tedla A, Mengiste B, Shenkute D, Tesema A, Shiferaw Y, Lulekal E (2020) In vitro antimicrobial activity of six Ethiopian medicinal plants against Staphylococcus aureus, Escherichia coli and Candida albicans. Eur J Integr Med 36:101121. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.eujim.2020.101121\nMailu JK, Nguta JM, Mbaria JM, Okumu MO (2020) Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya. Chin Med 15:95. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs13020-020-00374-2\nDemilew W, Adinew GM, Asrade S (2018) Evaluation of the wound healing activity of the crude extract of leaves of Acanthus polystachyus Delile (Acanthaceae). Evid Based Complement Altern Med 2018:1–9. https:\u002F\u002Fdoi.org\u002F10.1155\u002F2018\u002F2047896\nAsnake S, Teklehaymanot T, Hymete A, Erko B, Giday M (2016) Antimalarial medicinal plants used by Gumuz people of mandura woreda, benishangul-gumuz regional state, Ethiopia. Indian J Tradit Knowl 15(4):546–552\nTeklehaymanot T, Giday M, Medhin G, Mekonnen Y (2007) Knowledge and use of medicinal plants by people around Debre Libanos monastery in Ethiopia. J Ethnopharmacol 111:271–283\nRhynchosia elegans in Global Plants on JSTOR. https:\u002F\u002Fplants.jstor.org\u002Fcompilation\u002FRhynchosia.elegans. Accessed 1 May 2020\nKidane B, van Andel T, van der Maesen LJG, Asfaw Z (2014) Use and management of traditional medicinal plants by Maale and Ari ethnic communities in southern Ethiopia. J Ethnobiol Ethnomed 10:46. https:\u002F\u002Fdoi.org\u002F10.1186\u002F1746-4269-10-46\nKeetia gueinzii in Global Plants on JSTOR. https:\u002F\u002Fplants.jstor.org\u002Fcompilation\u002FKeetia.gueinzii. Accessed 1 May 2020\nNjoroge GN, Bussmann RW (2006) Diversity and utilization of antimalarial ethnophytotherapeutic remedies among the Kikuyus (Central Kenya). J Ethnobiol Ethnomed 2:1–7. https:\u002F\u002Fdoi.org\u002F10.1186\u002F1746-4269-2-8\nTadesse E, Engidawork E, Nedi T, Mengistu G (2017) Evaluation of the anti-diarrheal activity of the aqueous stem extract of Lantana camara Linn (Verbenaceae) in mice. BMC Complement Altern Med 17:1–8. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12906-017-1696-1\nYong YK, Zakaria ZA, Kadir AA, Somchit MN, Ee Cheng Lian G, Ahmad Z (2013) Chemical constituents and antihistamine activity of Bixa orellana leaf extract. BMC Complement Altern Med 13:32. https:\u002F\u002Fdoi.org\u002F10.1186\u002F1472-6882-13-32\nMostafa AA, Al-Askar AA, Almaary KS, Dawoud TM, Sholkamy EN, Bakri MM (2018) Antimicrobial activity of some plant extracts against bacterial strains causing food poisoning diseases. Saudi J Biol Sci 25:361–366. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.sjbs.2017.02.004\nNaz R, Ayub H, Nawaz S, Islam ZU, Yasmin T, Bano A, Wakeel A, Zia S, Roberts TH (2017) Antimicrobial activity, toxicity and anti-inflammatory potential of methanolic extracts of four ethnomedicinal plant species from Punjab, Pakistan. BMC Complement Altern Med 17:1–13. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12906-017-1815-z\nIqbal E, Salim KA, Lim LBL (2015) Phytochemical screening, total phenolics and antioxidant activities of bark and leaf extracts of Goniothalamus velutinus (Airy Shaw) from Brunei Darussalam. J King Saud Univ Sci 27:224–232. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jksus.2015.02.003\nPandey S (2015) Preliminary phytochemical screening and in vitro antibacterial activity of Bauhinia variegata Linn. against human pathogens. Asian Pac J Trop Dis 5:123–129. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS2222-1808(14)60639-3\nJaradat N, Hussen F, Al Ali A, Alniss H, Dweikat M (2015) Phytoconstituents, free radical scavenging potential, total phenols and total flavonoids assessments for Violet Horned Poppy from Jerusalem Mountains. J Mater Environ Sci 6:2958–2966\nUsman A, Abdulrahman FI, Usman A (2009) Qualitative phytochemical screening and in vitro antimicrobial effects of methanol stem bark extract of Ficus thonningii (Moraceae). AJTCAM 6:289–295. https:\u002F\u002Fdoi.org\u002F10.4314\u002Fajtcam.v6i3.57178\nHarnafi H, Caid HS, el Houda BN, Aziz M, Amrani S (2008) Hypolipemic activity of polyphenol-rich extracts from Ocimum basilicum in Triton WR-1339-induced hyperlipidemic mice. Food Chem 108:205–212\nSingleton VL, Orthofer R, Lamuela-Raventós RM (1999) Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent. Methods Enymol 1999:152–178\nOkumu MO, Mbaria JM, Kanja LW, Gakuya DW, Kiama SG, Ochola FO (2016) Phytochemical profile and antioxidant capacity of leaves of Moringa oleifera (lam) extracted using different solvent systems. J Pharmacogn Phytochem 5:302–308\nGouveia S, Castilho PC (2011) Antioxidant potential of Artemisia argentea L’Hér alcoholic extract and its relation with the phenolic composition. Food Res Int 44:1620–1631\nAtanassova M, Georgieva S, Ivancheva K (2011) Total phenolic and total flavonoid contents, antioxidant capacity and biological contaminants in medicinal herbs. JUCTM 46:81–88\nAmadi BA, Agomuo EN, Ibegbulem CO (2004) Proximate analysis. Research methods in biochemistry. Supreme Publishers, Owerri, pp 105–115\nEjikeme C, Ezeonu CS, Eboatu AN (2014) Determination of physical and phytochemical constituents of some tropical timbers indigenous to nigerdelta area of Nigeria. Eur Sci J 10:247–270\nSheikh N, Kumar Y, Misra AK, Pfoze L (2013) Phytochemical screening to validate the ethnobotanical importance of root tubers of Dioscorea species of Meghalaya North East India. J Med Plants 1:62–69\nTeh CH, Nazni WA, Nurulhusna AH, Norazah A, Lee HL (2017) Determination of antibacterial activity and minimum inhibitory concentration of larval extract of fly via resazurin-based turbidometric assay. BMC Microbiol 17:36. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12866-017-0936-3\nTeke GN, Elisée KN, Roger KJ (2013) Chemical composition, antimicrobial properties and toxicity evaluation of the essential oil of Cupressus lusitanica Mill leaves from Cameroon. BMC Complement Altern Med 13:130. https:\u002F\u002Fdoi.org\u002F10.1186\u002F1472-6882-13-130\nBalouiri M, Sadiki M, Ibnsouda SK (2016) Methods for in vitro evaluating antimicrobial activity: a review. J Pharm Anal 6:71–79. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jpha.2015.11.005\nWayne PA (2002) Reference method for broth dilution antifungal susceptibility testing of yeasts, approved standard, CLSI Document M27-A2.\nMeyer BN, Ferrigni NR, Putnam JE, Jacobsen LB, Nichols DE, McLaughlin JL (1982) Brine shrimp: a convenient general bioassay for active plant constituents. Planta Med 45:31–34\nFinney DJ (1952) Probit analysis: a statistical treatment of the sigmoid response curve. Cambridge University Press, Cambridge\nHamidi MR, Jovanova B, Kadifkova Panovska T (2014) Toxicological evaluation of the plant products using Brine Shrimp (Artemia salina L.) model. Maced Pharm Bull 60:9–18. https:\u002F\u002Fdoi.org\u002F10.33320\u002Fmaced.pharm.bull.2014.60.01.002\nClarkson C, Maharaj VJ, Crouch NR, Grace OM, Pillay P, Matsabisa MG, Bhagwandin N, Smith PJ, Folb PI (2004) In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa. J Ethnopharmacol 92:177–191\nVentola CL (2015) The antibiotic resistance crisis: part 1: causes and threats. Pharm Ther 40:277\nSpellberg B, Gilbert DN (2014) The future of antibiotics and resistance: a tribute to a career of leadership by John Bartlett. Clin Infect Dis 59(Suppl 2):S71–S75. https:\u002F\u002Fdoi.org\u002F10.1093\u002FCID\u002FCIU392\nReygaert WC (2018) An overview of the antimicrobial resistance mechanisms of bacteria. AIMS Microbiol 4:482\nPoole K (2007) Efflux pumps as antimicrobial resistance mechanisms. Ann Med 39:162–176\nSantajit S, Indrawattana N (2016) Mechanisms of antimicrobial resistance in ESKAPE pathogens. BioMed Res Int. https:\u002F\u002Fdoi.org\u002F10.1155\u002F2016\u002F2475067\nGould IM, Bal AM (2013) New antibiotic agents in the pipeline and how they can help overcome microbial resistance. Virulence 4:185–191. https:\u002F\u002Fdoi.org\u002F10.4161\u002FVIRU.22507\nMichael CA, Dominey-Howes D, Labbate M (2014) The antimicrobial resistance crisis: causes, consequences, and management. Front Public Health. https:\u002F\u002Fdoi.org\u002F10.3389\u002FFPUBH.2014.00145\nAnand U, Jacobo-Herrera N, Altemimi A, Lakhssassi N (2019) A comprehensive review on medicinal plants as antimicrobial therapeutics: potential avenues of biocompatible drug discovery. Metabolites 9:258\nBouyahya A, Bakri Y, Khay EO, Edaoudi F, Talbaoui A, Et-Touys A, Abrini J, Dakka N (2017) Antibacterial, antioxidant and antitumor properties of Moroccan medicinal plants: a review. Asian Pac J Trop Dis 7:57–64\nSharma A, del Carmen F-V, Cardoso-Taketa A, Villarreal ML (2017) Antibacterial activities of medicinal plants used in Mexican traditional medicine. J Ethnopharmacol 208:264–329\nAkhalwaya S, Van Vuuren S, Patel M (2018) An in vitro investigation of indigenous South African medicinal plants used to treat oral infections. J Ethnopharmacol 210:359–371\nManandhar S, Luitel S, Dahal RK (2019) In vitro antimicrobial activity of some medicinal plants against human pathogenic bacteria. J Trop Med. https:\u002F\u002Fdoi.org\u002F10.1155\u002F2019\u002F1895340\nDirar AI, Alsaadi DHM, Wada M, Mohamed MA, Watanabe T, Devkota HP (2019) Effects of extraction solvents on total phenolic and flavonoid contents and biological activities of extracts from Sudanese medicinal plants. S Afr J Bot 120:261–267. https:\u002F\u002Fdoi.org\u002F10.1016\u002FJ.SAJB.2018.07.003\nFarooq A (2012) Effect of solvents extraction on total phenolics and antioxidant activity of extracts from flaxseed (Linum usitatissimum L.). Acta Sci Pol Technol Ailment 11(3):293–301\nNureye D, Assefa S, Nedi T, Engidawork E (2018) In vivo antimalarial activity of the 80% methanolic root bark extract and solvent fractions of Gardenia ternifolia Schumach. & Thonn. (Rubiaceae) against Plasmodium berghei. Evid Based Complement Altern Med. https:\u002F\u002Fdoi.org\u002F10.1155\u002F2018\u002F9217835\nNasr A, Zhou X, Huang SP, Wang Y, Li X, Zhu GP (2018) Comparative effects of some extraction solvents on the antimicrobial activity of Eucalyptus camaldulensis leaf, bud, capsule and seed crude extracts. Nat Prod Res 33:2560–2565. https:\u002F\u002Fdoi.org\u002F10.1080\u002F14786419.2018.1455049\nKuncharoen N, Mai Sci CJ, Nanasombat S, Ritcharoon B, Sukcharoen P (2018) Antibacterial activity of thai medicinal plant extracts against oral and gastrointestinal pathogenic bacteria and prebiotic effect on the growth of lactobacillus acidophilus. Chiang Mai J Sci 45(1):33–44\nJafari-Sales A, Jafari B, Khaneshpour H, Pashazadeh M (2020) Antibacterial effect of methanolic extract of rosa damascena on standard bacteria Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa in vitro. 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Saudi J Biol Sci 27:3221–3227\nNajee H, Kamerzan C, Marutescu L, Gheorghe I, Popa M, Grădișteanu G, Lazăr V (2018) Antifungal activity of some medicinal plant extracts against Candida albicans nosocomial isolates. Rom Biotechnol Lett 23:14073. https:\u002F\u002Fdoi.org\u002F10.26327\u002FRBL2018.190\nGuo N, Liu J, Wu X, Bi X, Meng R, Wang X, Xiang H, Deng X, Yu L (2009) Antifungal activity of thymol against clinical isolates of fluconazole-sensitive and-resistant Candida albicans. J Med Microbiol 58:1074–1079\nAryal S, Baniya MK, Danekhu K, Kunwar P, Gurung R, Koirala N (2019) Total phenolic content, flavonoid content and antioxidant potential of wild vegetables from western Nepal. Plants 8:96. https:\u002F\u002Fdoi.org\u002F10.3390\u002FPLANTS8040096\nNg ZX, Samsuri SN, Yong PH (2020) The antioxidant index and chemometric analysis of tannin, flavonoid, and total phenolic extracted from medicinal plant foods with the solvents of different polarities. J Food Process Preserv. https:\u002F\u002Fdoi.org\u002F10.1111\u002FJFPP.14680\nTlili H, Marino A, Ginestra G, Cacciola F, Mondello L, Miceli N, Taviano MF, Najjaa H, Nostro A (2021) Polyphenolic profile, antibacterial activity and brine shrimp toxicity of leaf extracts from six Tunisian spontaneous species. Nat Prod Res 35:1057–1063\nLestari MS, Himawan T, Abadi AL, Retnowati R (2015) Toxicity and phytochemistry test of methanol extract of several plants from Papua using the Brine Shrimp Lethality Test (BSLT). J Chem Pharm Res 7:866–872\nSeremet OC, Olaru OT, Gutu CM, Nitulescu GM, Ilie M, Negres S, Zbarcea CE, Purdel CN, Spandidos DA, Tsatsakis AM (2018) Toxicity of plant extracts containing pyrrolizidine alkaloids using alternative invertebrate models. Mol Med Rep 17:7757–7763\nPopovici V, Bucur L, Popescu A, Schröder V, Costache T, Rambu D, Cucolea IE, Gîrd CE, Caraiane A, Gherghel D, Vochita G, Badea V (2021) Antioxidant and cytotoxic activities of Usnea barbata (L.) F.H. Wigg. Dry extracts in different solvents. Plants 10:909. https:\u002F\u002Fdoi.org\u002F10.3390\u002FPLANTS10050909",{"EN":669},"The root, root bark, and root tubers of Acanthus polystachyus, Keetia gueinzii, and Rhynchosia elegans are used for managing bacterial and fungal infections among the Luo community of Kisumu East Sub County in Kenya. However, data on the efficacy of these plants against common bacterial and fungal pathogens is not available. The safety of these plants is also not known. This study aimed to investigate the phytochemical composition, antimicrobial properties, and safety of different solvent extracts of the roots, root barks, and root tubers of Acanthus polystachyus, Keetia gueinzii, and Rhynchosia elegans. The broth microdilution method evaluated the antimicrobial activities of the root, root bark, and root tuber extracts (water, acetone, and methanol) of Acanthus polystachyus, Keetia gueinzii, and Rhynchosia elegans. Gram-positive (Bacillus cereus, Staphylococcus aureus), gram-negative (Escherichia coli), and fungal (Candida albicans) microorganisms were used in the evaluation. The safety of the extracts was evaluated in Artemia salina. The phytochemical composition of the extracts was determined using qualitative and quantitative assays. In general, the extracts of Acanthus polystachyus, Keetia gueinzii, and Rhynchosia elegans displayed poor antimicrobial properties relative to conventional antimicrobial agents including Amoxicillin, Gentamicin, and Nystatin. The aqueous extract of Acanthus polystachyus and the aqueous, acetone, and methanol extracts of Keetia gueinzii were safe in Artemia salina but all other extracts were cytotoxic to Artemia salina. These findings suggest that the use of the roots, root barks, and root tubers of Acanthus polystachyus, Keetia gueinzii, and Rhynchosia elegans is limited by poor antimicrobial efficacy and cytotoxicity.",{"EN":671},"Qualitative and quantitative phytochemical composition, antimicrobial activity, and brine shrimp cytotoxicity of different solvent extracts of Acanthus polystachyus, Keetia gueinzii, and Rhynchosia elegans",{"VOID":673},"10.1186\u002Fs43094-021-00342-z","https:\u002F\u002Ffjps.springeropen.com\u002Farticles\u002F10.1186\u002Fs43094-021-00342-z",[676,705,717,729],{"id":677,"sortIndex":508,"researcher":20,"roles":678,"affiliations":679,"properties":702},"341e6245-2f28-4c84-a4e2-854f20e26998",[121],[680,690],{"id":20,"sortIndex":21,"affiliation":681,"properties":20},{"id":682,"createTime":683,"updateTime":684,"relativeEntities":685,"slug":686,"properties":687,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"014f6cf3-6af6-4b92-930e-7b71667d28c8","2024-01-16T09:24:05.442+00:00","2025-06-11T14:46:23.638+00:00",[],"Department-of-Public-Health-Pharmacology-and-Toxicology-Faculty-of-Veterinary-Medicine-University-of-Nairobi-Nairobi-Kenya",{"title":688},{"VI":689},"Department of Public Health, Pharmacology, and Toxicology, Faculty of Veterinary Medicine, University of Nairobi, Nairobi, Kenya",{"id":691,"sortIndex":137,"affiliation":692,"properties":701},"fe0d29ae-d60b-42a9-a11a-08f91859a155",{"id":693,"createTime":694,"updateTime":695,"relativeEntities":696,"slug":697,"properties":698,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"fe8c3bba-78c7-4485-b5b6-325112280842","2024-01-16T09:24:05.459+00:00","2025-02-04T10:50:02.049+00:00",[],"Department-of-Pharmacy-Jaramogi-Oginga-Odinga-Teaching-and-Referral-Hospital-Kisumu-Kenya",{"title":699},{"VI":700},"Department of Pharmacy, Jaramogi Oginga Odinga Teaching and Referral Hospital, Kisumu, Kenya",{},{"title":703},{"VI":704},"Mitchel Otieno Okumu",{"id":706,"sortIndex":137,"researcher":20,"roles":707,"affiliations":708,"properties":714},"cfd2fb08-09c3-4b7c-a1de-1f96fab3f7eb",[121],[709],{"id":20,"sortIndex":21,"affiliation":710,"properties":20},{"id":682,"createTime":683,"updateTime":684,"relativeEntities":711,"slug":686,"properties":712,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":713},{"VI":689},{"title":715},{"VI":716},"Joseph Mwanzia Nguta",{"id":718,"sortIndex":85,"researcher":20,"roles":719,"affiliations":720,"properties":726},"0f37bae7-656f-48c8-915f-59384655d813",[121],[721],{"id":20,"sortIndex":21,"affiliation":722,"properties":20},{"id":682,"createTime":683,"updateTime":684,"relativeEntities":723,"slug":686,"properties":724,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":725},{"VI":689},{"title":727},{"VI":728},"James Mucunu Mbaria",{"id":730,"sortIndex":21,"researcher":20,"roles":731,"affiliations":732,"properties":748},"391156b6-e3bd-4593-a227-d2934f165adf",[121],[733,743],{"id":734,"sortIndex":137,"affiliation":735,"properties":742},"9e03e9e4-dc43-4958-9835-a03d2f86c73a",{"id":736,"createTime":737,"updateTime":737,"relativeEntities":738,"slug":20,"properties":739,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"f77914b5-779a-4a45-a8e5-6cb25e075d33","2024-01-25T22:05:31.802+00:00",[],{"title":740},{"VI":741},"Department of Pharmacy, Kenya Medical Training College, Kisumu Campus Kenya, Kisumu, Kenya",{},{"id":20,"sortIndex":21,"affiliation":744,"properties":20},{"id":682,"createTime":683,"updateTime":684,"relativeEntities":745,"slug":686,"properties":746,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":747},{"VI":689},{"title":749},{"VI":750},"James Kiamba Mailu",{"url":674,"publisher":752,"properties":773},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":753,"slug":10,"properties":754,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":758,"manageAffiliations":759,"indexDatabases":760,"url":20,"thumbnailPath":20,"statistic":768,"gsStatistic":20,"type":92,"analyzePriority":20},[],{"issn":755,"title":756,"url":757},{"VOID":13},{"EN":15},{"VOID":17},[],[],[761],{"id":44,"indexDatabase":762,"url":59,"indexYears":20,"academicFieldIds":767,"indexDatabaseRanking":20},{"id":46,"createTime":47,"updateTime":48,"relativeEntities":763,"label":764,"description":765,"key":55,"publicationTags":766,"standard":20},[],{"EN":51,"VI":51},{"VI":53,"EN":54},[57,58],[61],{"impactFactor":21,"impactFactorByYear":769,"i10Index":68,"i10IndexLast5Year":69,"totalPublication":70,"totalPublicationByYear":770,"totalCitation":80,"totalCitationByYear":771,"totalCitationPerPublication":86,"totalCitationPerPublicationByYear":772,"hindexLast5Year":68,"hindex":68},{"2020":64,"2021":65,"2022":66,"2023":67},{"2015":72,"2016":72,"2017":69,"2018":73,"2019":74,"2020":75,"2021":76,"2022":77,"2023":78,"2024":79},{"2019":82,"2020":83,"2021":84,"2022":85},{"2019":88,"2020":89,"2021":90,"2022":91},{"volume":774,"pages":775},{"VOID":569},{"VOID":270},"2021-09-28",{"id":778,"createTime":779,"updateTime":780,"relativeEntities":781,"slug":782,"properties":783,"entityType":112,"verifyStatus":113,"verifyTime":780,"verifyNote":115,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":137,"primaryUrl":792,"fullTextUrl":20,"authors":793,"publicationType":151,"publisherRelationship":856,"citationCount":20,"citationInfo":20,"publishDate":882,"publishYear":573,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":20,"isForceReanalyzing":181},"71db2923-9675-42b8-9326-c6053ba81e92","2023-11-18T06:10:55.748+00:00","2024-12-31T23:41:29.406+00:00",[],"Cocrystallization-of-gliclazide-with-improved-physicochemical-properties",{"references":784,"abstract":786,"title":788,"doi":790},{"VOID":785},"Kawabata Y, Wada K, Nakatani M, Yamada S, Onoue S (2011) Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications. Int J Pharm 420(1):1–10. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijpharm.2011.08.032\nGood DJ, Rodriguez-Hornedo N (2009) Solubility advantage of pharmaceutical cocrystals. Cryst Growth Des 9(5):2252–2264. https:\u002F\u002Fdoi.org\u002F10.1021\u002Fcg801039j\nSerajuddin ATM (2007) Salt formation to improve drug solubility. Adv Drug Deliv Rev 59(7):603–616. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.addr.2007.05.010\nTorchillin VP (2007) Micellar nanocarriers: pharmaceutical perspectives. Pharm Res 24:1–16\nZahra ZA, Sahar ZA (2019) Preparation and characterization of curcumin niosomal nanoparticles via a simple and eco-friendly route. J Nanostruct 9:784–790\nNader TQ, Zinatloo S (2011) Synthesis and characterization of gelatin nanoparticles using CDI\u002FNHS as a non-toxic cross-linking system. J Mater Sci Mater Med 22:63–69\nSahar ZA, Nader TQ (2014) Inverse miniemulsion method for synthesis of gelatin nanoparticles in presence of CDI\u002FNHS as a non-toxic cross-linking system. J Nanostruct 4:267–275\nSahar ZA, Nader TQ (2015) Effect of some synthetic parameters on size and polydispersity index of gelatin nanoparticles cross-linked by CDI\u002FNHS system. J Nanostruct 5:137–144\nMullauer FB, Van BL, Daalhuisen JB, Ten BMS, Storm G, Medema JP, Schiffelers RM, Kessler JH (2011) Betulinic acid delivered in liposomes reduces growth of human lung and colon cancers in mice without causing systemic toxicity. Anti-Cancer Drugs 22(3):223–233. https:\u002F\u002Fdoi.org\u002F10.1097\u002FCAD.0b013e3283421035\nHu L, Jia Y, Niu F, Zheng J, Yang X, Jiao K (2012) Preparation and enhancement of oral bioavailability of curcumin using microemulsions vehicle. J Agric Food Chem 60(29):7137–7141. https:\u002F\u002Fdoi.org\u002F10.1021\u002Fjf204078t\nDehelean CA, Feflea S, Gheorgheosu D, Ganta S, Cimpean AM, Muntean D, Amiji MM (2013) Anti-angiogenic and anti-cancer evaluation of betulin nanoemulsion in chicken chorioallantoic membrane and skin carcinoma in BALB\u002Fc mice. J Biomed Nanotechnol 9(4):577–589. https:\u002F\u002Fdoi.org\u002F10.1166\u002Fjbn.2013.1563\nTan JM, Govindarajan K, Arulselvan P, Fakurazi S, Hussein MZ (2014) Sustained release and cytotoxicity evaluation of carbon nanotube-mediated drug delivery system for betulinic acid. J Nanomater 2014:1–11. https:\u002F\u002Fdoi.org\u002F10.1155\u002F2014\u002F862148\nFrijlink HW, Eissens AC, Hefting NR, Poelstra K, Lerk CF, Meijer DKF (1991) The effect of parenterally administered cyclodextrins on cholesterol levels in the rat. Pharm Res 8(1):9–16. https:\u002F\u002Fdoi.org\u002F10.1023\u002FA:1015861719134\nSingh S, Baghel R, Yadav L (2011) A review on solid dispersion. Int J Pharm Life Sci 2:1078–1095\nDevarajan PV, Sonavane GS (2007) Preparation and in vitro\u002Fin vivo evaluation of gliclazide loaded Eudragit nanoparticles as sustained release carriers. Drug Dev Ind Pharm 33(2):101–111. https:\u002F\u002Fdoi.org\u002F10.1080\u002F03639040601096695\nPatel H, Pandey N, Patel B, Ranch K, Bodiwala K, Vyas B (2020) Enhancement of in vivo hypoglycemic effect of gliclazide by developing self-microemulsifying pellet dosage form. Future J Pharm Sci 6(1):17. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs43094-020-00034-0\nAitipamula S, Banerjee R, Bansal AK, Biradha K, Cheney ML, Choudhary AR, Desiraju GR, Dikundwar AG, Dubey R, Duggirala N, Ghogale PP, Gosh S, Goswami PK, Goud NR, Jetti RKR, Karpinski P, Kaushik P, Kumar D, Kumar V, Moulton B, Mukherjee A, Mukherjee G, Myerson AS, Puri V, Ramanan A, Rajamannar T, Reddy CM, Hornedo RN, Rogers RD, Row TNG, Sanphui P, Shan N, Shete G, Singh A, Sun CC, Swift JA, Thaimattam R, Thakur TS, Thaper RK, Thomas SP, Tothadi S, Vangala VR, Narayan V, Peddy V, Weyna D, Zawortko MJ (2012) Polymorphs, salts, and cocrystals: what’s in name? Cryst Growth Des 12(5):2147–2152. https:\u002F\u002Fdoi.org\u002F10.1021\u002Fcg3002948\nSrivastava D, Fatima Z, Kaur CD (2018) Multicomponent pharmaceutical cocrystals: a novel approach for combination therapy. Mini-Rev Med Chem 18(14):1160–1167. https:\u002F\u002Fdoi.org\u002F10.2174\u002F1389557518666180305163613\nVishweshwar P, McMahon JA, Bis JA, Zaworotko MJ (2006) Pharmaceutical co-crystals. J Pharm Sci 95(3):499–516. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fjps.20578\nThipparaboina R, Kumar D, Chavan RB, Shastri NR (2016) Multi drug cocrystals: towards the development of effective therapeutic hybrids. Drug Discov Today 21(3):481–490. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.drudis.2016.02.001\nMoulton B, Zaworotko MJ (2011) From molecules to crystal engineering: supramolecular isomerism and polymorphism in network solids. Chem Rev 101:1629–1658\nImamura M, Nakanishi K, Shiraki R, Onda K, Sasuga D, Yuda M (2012) Cocrystal of C-glycoside derivative and L-proline. US patent 8, 097, 592 B2 (17 January 2012).\nThipparaboina R, Kumar D, Chavan RB, Shastri NR (2016) Multi drug co-crytals: towards the development of effective therapeutic hybrids. Drug Discov Today 21(3):481–490. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.drudis.2016.02.001\nHarrison WT, Yathirajan HS, Bindya S, Anilkumar HG, Devaraju (2007) Escitalopram oxalate: co-existence of oxalate dianions and oxalic acid molecules in the same crystal. Acta Crystallogr C 63(Pt 2):12931\nMascitti V, Thuma BA, Smith AC, Robinson RP, Brandt T, Kalgutkar AS, Maurer TS, Samas B, Sharma R (2013) On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozin. Med Chem Commun 4(1):101–111. https:\u002F\u002Fdoi.org\u002F10.1039\u002FC2MD20163A\nChavan RB, Thipparaboina R, Yadav B, Shastri NR (2018) Continuous manufacturing of co-crystals: challenges and prospects. Drug Deliv Transl Res 19:1–4\nBhandaru JS, Malothu N, Akkinepally RR (2015) Characterization and solubility studies of pharmaceutical cocrystals of eprosartan mesylate cocrystals. Cryst Growth Des 15(3):1173–1179. https:\u002F\u002Fdoi.org\u002F10.1021\u002Fcg501532k\nEesam S, Bhandaru JS, Naliganti C, Bobbala RK, Akkinepally RR (2020) Solubility enhancement of carvedilol using drug–drug cocrystallization with hydrochlorothiazide. Futur J Pharm Sci 6(1):77. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs43094-020-00083-5\nGoogle Search on “glyclazide cocrystals”. 11, 300 citations on 04\u002F12\u002F2020.\nBruni G, Berbenni V, Maggi L, Mustarelli P, Friuli V, Ferrara C, Pardi F, Castagna F, Girella A, Milanese C, Marini A (2017) Multicomponent crystals of gliclazide and tromethamine: preparation, physico-chemical, and pharmaceutical characterization. Drug Dev Ind Pharm 44:243–250\nChadha R, Dimpy R, Goyal P (2016) Novel cocrystals of gliclazide: characterization and evaluation. CrystEngComm 18(13):2275–2283. https:\u002F\u002Fdoi.org\u002F10.1039\u002FC5CE02402A\nChadha R, Dimpy R, Goyal P (2017) Supramolecular cocrystals of gliclazide: synthesis, characterization and evaluation. Pharm Res 34(3):552–563. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11095-016-2075-1\nIbrahim AY, El-Malah Y, Abourehab MAS (2019) Solubility enhancement of gliclazide via co-crystallization with malonic acid. Life Sci J 16:49–53\nSamie A, Desiraju GR, Banik M (2017) Salts and cocrystals of the antidiabetic drugs gliclazide, tolbutamide, and glipizide: solubility enhancements through drug–coformer interactions. Cryst Growth Des 17(5):2406–2417. https:\u002F\u002Fdoi.org\u002F10.1021\u002Facs.cgd.6b01804\nPutra OD, Furuishi T, Yonemochi E, Terada K, Uekusa H (2016) Drug–drug multicomponent crystals as an effective technique to overcome weaknesses in parent drugs. Cryst Growth Des 16(7):3577–3581. https:\u002F\u002Fdoi.org\u002F10.1021\u002Facs.cgd.6b00639\nMarwah A, Pól MF, Patrick M, Andrea E (2019) Investigation of the formation of drug-drug cocrystals and coamorphous systems of the antidiabetic drug gliclazide. Int J Pharm 561:35–42\nMaggi L, Canobbio A, Bruni G, Musitelli G, Conte U (2015) Improvement of the dissolution behavior of gliclazide, a slightly soluble drug, using solid dispersions. J Drug Deliv Sci Technol 26:17–23. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jddst.2015.01.002\nNewman AW, Byrn SR (2003) Solid-state analysis of the active pharmaceutical ingredient in drug products. Drug Discov Today 8(19):898–905. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS1359-6446(03)02832-0\nNaqvi A, Ahmad M, Minhas MU, Khan KU, Batool F, Rizwan A (2020) Preparation and evaluation of pharmaceutical co-crystals for solubility enhancement of atorvastatin calcium. Polym Bull 77(12):6191–6211. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00289-019-02997-4\nBhalla Y, Chadha K, Chadha R, Karan M (2019) Daidzein cocrystals: an opportunity to improve its biopharmaceutical parameters. Heliyon 5(11):e02669. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.heliyon.2019.e02669\nICH Guideline Q1A(R) (2000) Stability testing of new drugs and products. ICH, Geneva www.eudra.org\u002Femea.html\nGlomme A, Marz J, Dressman JB (2005) Comparison of a miniaturized shake-flask solubility method with automated potentiometric acid\u002Fbase titrations and calculated solubilities. J Pharm Sci 94(1):1–16. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fjps.20212\nGadade DD, Kulkarni DA, Rathi PB, Pekamwar SS, Joshi SS (2017) Solubility enhancement of lornoxicam by crystal engineering. Indian J Pharm Sci 79:277–286",{"EN":787},"Cocrystallization is one of the crystal engineering strategies used to alter the physicochemical properties of drugs that are poorly water-soluble. Gliclazide (GLZ), an antidiabetic drug, belongs to Biopharmaceutical Classification System class-II (low solubility and high permeability) and has low bioavailability, resulting in poor therapeutic effects in patients. Therefore, to impart better solubility and bioavailability of GLZ, the study was carried out by preparing GLZ cocrystals using liquid-assisted grinding method with three coformers [3,5-dinitrosalicylic acid (DNS), 2,6-pyridine dicarboxylic acid (PDA), and L-proline (LPN)], and these were characterized using Differential Scanning Colorimetry (DSC), Powder X-ray diffraction (PXRD), Fourier Transform Infra-red spectroscopy (FTIR), and Raman spectral studies. Further, Scanning electron microscopy (SEM) analysis, accelerated stability, solubility, in vitro dissolution studies, and in vivo pharmacokinetic studies were performed in male Wistar rats. DSC and PXRD analysis confirmed the formation of the GLZ cocrystals. Hydrogen bonding between pure GLZ and its coformers was demonstrated based on FTIR and Raman analysis. SEM data showed morphological images for GLZ cocrystals differed from those of pure GLZ. In comparison with pure GLZ, these GLZ cocrystals have greatly improved solubility, in vitro dissolution, and in vivo profiles. Among the three, GLZ–DNS cocrystals outperformed the pure drug in terms of solubility (6.3 times), degradation (1.5 times), and relative bioavailability (1.8 times). Hence, cocrystallization of GLZ leads to improved physicochemical properties of poorly soluble drug gliclazide.",{"EN":789},"Cocrystallization of gliclazide with improved physicochemical properties",{"VOID":791},"10.1186\u002Fs43094-021-00261-z","https:\u002F\u002Ffjps.springeropen.com\u002Farticles\u002F10.1186\u002Fs43094-021-00261-z",[794,811,826,841],{"id":795,"sortIndex":21,"researcher":20,"roles":796,"affiliations":797,"properties":808},"00a76ecc-4c04-4fb2-a9b7-69fa053c2477",[121],[798],{"id":20,"sortIndex":21,"affiliation":799,"properties":20},{"id":800,"createTime":801,"updateTime":802,"relativeEntities":803,"slug":804,"properties":805,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"c0fb3e59-b670-4f3d-b487-7d33d4bb1cf6","2023-11-18T06:11:10.992+00:00","2023-12-22T15:06:47.893+00:00",[],"Piramal-Pharma-Limited-Zaheerabad-India",{"title":806},{"VI":807},"Piramal Pharma Limited, Zaheerabad, India",{"title":809},{"VI":810},"Jaswanth S. Bhandaru",{"id":812,"sortIndex":21,"researcher":20,"roles":813,"affiliations":814,"properties":823},"739d5f3d-66c9-4497-9c54-21a69d696a3f",[121],[815],{"id":20,"sortIndex":21,"affiliation":816,"properties":20},{"id":817,"createTime":818,"updateTime":818,"relativeEntities":819,"slug":20,"properties":820,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"1c1a1135-43bb-4b39-a540-6d14e6ba0db0","2024-01-19T04:34:01.064+00:00",[],{"title":821},{"VI":822},"Department of Medicinal Chemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India",{"title":824},{"VI":825},"Shivarani Eesam",{"id":827,"sortIndex":21,"researcher":20,"roles":828,"affiliations":829,"properties":838},"36a42216-cf37-4074-8214-021f991509ec",[121],[830],{"id":831,"sortIndex":21,"affiliation":832,"properties":836},"a451e98e-2fe9-4c7b-b3e8-4676fd9cc45f",{"id":817,"createTime":818,"updateTime":818,"relativeEntities":833,"slug":20,"properties":834,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":835},{"VI":822},{"title":837},{"VI":822},{"title":839},{"VI":840},"Raghuram Rao Akkinepally",{"id":842,"sortIndex":21,"researcher":20,"roles":843,"affiliations":844,"properties":853},"1ac275d4-585f-44b6-bf37-6a3a0831d541",[121],[845],{"id":846,"sortIndex":21,"affiliation":847,"properties":851},"d5078d18-4783-4704-995d-d83b711fa6fd",{"id":817,"createTime":818,"updateTime":818,"relativeEntities":848,"slug":20,"properties":849,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":850},{"VI":822},{"title":852},{"VI":822},{"title":854},{"VI":855},"Ravi Kumar Bobbala",{"url":792,"publisher":857,"properties":878},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":858,"slug":10,"properties":859,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":863,"manageAffiliations":864,"indexDatabases":865,"url":20,"thumbnailPath":20,"statistic":873,"gsStatistic":20,"type":92,"analyzePriority":20},[],{"issn":860,"title":861,"url":862},{"VOID":13},{"EN":15},{"VOID":17},[],[],[866],{"id":44,"indexDatabase":867,"url":59,"indexYears":20,"academicFieldIds":872,"indexDatabaseRanking":20},{"id":46,"createTime":47,"updateTime":48,"relativeEntities":868,"label":869,"description":870,"key":55,"publicationTags":871,"standard":20},[],{"EN":51,"VI":51},{"VI":53,"EN":54},[57,58],[61],{"impactFactor":21,"impactFactorByYear":874,"i10Index":68,"i10IndexLast5Year":69,"totalPublication":70,"totalPublicationByYear":875,"totalCitation":80,"totalCitationByYear":876,"totalCitationPerPublication":86,"totalCitationPerPublicationByYear":877,"hindexLast5Year":68,"hindex":68},{"2020":64,"2021":65,"2022":66,"2023":67},{"2015":72,"2016":72,"2017":69,"2018":73,"2019":74,"2020":75,"2021":76,"2022":77,"2023":78,"2024":79},{"2019":82,"2020":83,"2021":84,"2022":85},{"2019":88,"2020":89,"2021":90,"2022":91},{"volume":879,"pages":880},{"VOID":569},{"VOID":881},"1-13","2021-06-25",{"id":884,"createTime":885,"updateTime":886,"relativeEntities":887,"slug":888,"properties":889,"entityType":112,"verifyStatus":113,"verifyTime":886,"verifyNote":115,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":899,"fullTextUrl":20,"authors":900,"publicationType":151,"publisherRelationship":1000,"citationCount":20,"citationInfo":20,"publishDate":1022,"publishYear":1023,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":20,"isForceReanalyzing":181},"5091bf40-0a52-44a6-8405-567363346a0d","2024-04-08T00:20:06.317+00:00","2024-12-06T23:37:45.606+00:00",[],"Chlorzoxazone-reduced-the-paracetamol-induced-toxicity-via-competitive-inhibition-of-CYP2E1-mediated-metabolism",{"references":890,"keywords":892,"abstract":893,"title":895,"doi":897},{"VOID":891},"Jóźwiak-Bebenista M, Nowak JZ (2014) Paracetamol: mechanism of action, applications and safety concern. 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JAMA 272:1845–1850\nZimmerman HJ, Maddrey WC (1995) Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure. Hepatology 22:767–773\nBrackett CC, Bloch JD (2000) Phenytoin as a possible cause of acetaminophen hepatotoxicity: case report and review of the literature. Pharmacotherapy 20:229–233\nO’Shea D, Kim RB, Wilkinson GR (1997) Modulation of CYP2EI activity by isoniazid in rapid and slow N-acetylators. Br J Clin Pharmacol 43:99–103\nParacetamol interaction, reactions weekly, 2001;853:10.\nHenderson NC, Pollock KJ, Frew J, Mackinnon AC, Flavell RA, Davis RJ, Sethi T, Simpson KJ (2007) Critical role of c-jun (NH2) terminal kinase in paracetamol-induced acute liver failure. Gut 56:982–990\nSchmidt LE, Dalhoff K (2003) The impact of current tobacco use on the outcome of paracetamol poisoning. Aliment Pharmacol Ther 18:979–985",{"EN":433},{"EN":894},"Drug metabolism is crucial to attaining the therapeutic index of any drug. The metabolism and elimination of the drugs are governed mainly by P-glycoprotein (P-gp) and Cytochrome P450 (CYP). Paracetamol is mostly used as analgesic and antipyretic agent. The metabolism of paracetamol is primarily via Glucuronidation and sulphation at therapeutic doses. About 5–10% of paracetamol is metabolized via CYP mediated pathway. Cytochrome P450 2E1 (CYP2E1) is primarily responsible for forming a toxic metabolite of paracetamol called N-acetyl-p-benzoquinoneimine (NAPQI). Even at therapeutic doses, long-term usage of paracetamol leads to the hepatic and nephrotoxicity because of NAPQI. Several in-vitro and in-vivo studies conducted by different research groups and reported that chlorzoxazone is a substrate and inhibitor of CYP2E1. However, the effect of chlorzoxazone on the paracetamol (CYP2E1 substrate) metabolism via the CYP2E1 has not yet been reported. This study investigated the effect of chlorzoxazone on the CYP2E1-mediated metabolism of Paracetamol and NAPQI formation in Wistar rats. For 15 days, animals were orally administered with Paracetamol (300 mg\u002Fkg) with and without Silymarin (100 mg\u002Fkg) (standard CYP2E1 inhibitor) and Chlorzoxazone (50 and 100 mg\u002Fkg). Analysis was performed using RP-HPLC on the 15th day to determine paracetamol and NAPQI concentration in the plasma. Paracetamol combination with chlorzoxazone (50 and 100 mg\u002Fkg) showed a dose-dependent increase in the AUC0–∞ and the peak plasma concentration (Cmax) of Paracetamol and a dose-dependent decrease of AUC0–∞ and Cmax of NAPQI compared to paracetamol control (p \u003C 0.001). Chlorzoxazone significantly decreased the elevated liver and renal markers compared to paracetamol control. Simultaneously, Hepatic and nephrotic tissue studies showed that compared to the paracetamol control group, the combination of chlorzoxazone significantly ameliorated paracetamol-induced hepatotoxicity and nephrotoxicity. Finally, this study revealed that paracetamol in combination with chlorzoxazone led to a significant decrease in the plasma levels of NAPQI and enhanced absorption of paracetamol in rats via the inhibition of CYP2E1- mediated metabolism. In addition, chlorzoxazone significantly ameliorated paracetamol-induced hepatotoxicity and nephrotoxicity.",{"EN":896},"Chlorzoxazone reduced the paracetamol-induced toxicity via competitive inhibition of CYP2E1-mediated metabolism",{"VOID":898},"10.1186\u002Fs43094-023-00484-2","https:\u002F\u002Ffjps.springeropen.com\u002Farticles\u002F10.1186\u002Fs43094-023-00484-2",[901,916,936,948,960,972,988],{"id":902,"sortIndex":508,"researcher":20,"roles":903,"affiliations":904,"properties":913},"05947753-a693-48a5-bfff-2e19770e2f8d",[121],[905],{"id":20,"sortIndex":21,"affiliation":906,"properties":20},{"id":907,"createTime":908,"updateTime":908,"relativeEntities":909,"slug":20,"properties":910,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"470f261f-e723-49a8-ba98-df48d00e7097","2024-01-11T12:22:54.416+00:00",[],{"title":911},{"VI":912},"Department of Pharmaceutics and Pharmaceutical Biotechnology, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, India",{"title":914},{"VI":915},"Divya Presingu",{"id":917,"sortIndex":137,"researcher":20,"roles":918,"affiliations":919,"properties":933},"940fbb94-e424-4643-bf84-a8e60b7ccb34",[121],[920,925],{"id":20,"sortIndex":21,"affiliation":921,"properties":20},{"id":907,"createTime":908,"updateTime":908,"relativeEntities":922,"slug":20,"properties":923,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":924},{"VI":912},{"id":20,"sortIndex":21,"affiliation":926,"properties":20},{"id":927,"createTime":928,"updateTime":928,"relativeEntities":929,"slug":20,"properties":930,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"34f8f436-03c3-4a2f-9fe8-1974ab59ee42","2024-01-30T13:51:44.936+00:00",[],{"title":931},{"VI":932},"Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, USA",{"title":934},{"VI":935},"Sridhar Vemulapalli",{"id":937,"sortIndex":85,"researcher":20,"roles":938,"affiliations":939,"properties":945},"296acd35-bc33-4b95-8aff-1185a5aaf255",[121],[940],{"id":20,"sortIndex":21,"affiliation":941,"properties":20},{"id":907,"createTime":908,"updateTime":908,"relativeEntities":942,"slug":20,"properties":943,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":944},{"VI":912},{"title":946},{"VI":947},"Manideep V. V. N. Gadamsetty",{"id":949,"sortIndex":72,"researcher":20,"roles":950,"affiliations":951,"properties":957},"76a41ecc-5fa0-4e24-95c9-e0e8653a02e2",[121],[952],{"id":20,"sortIndex":21,"affiliation":953,"properties":20},{"id":907,"createTime":908,"updateTime":908,"relativeEntities":954,"slug":20,"properties":955,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":956},{"VI":912},{"title":958},{"VI":959},"Naveen Babu Kilaru",{"id":961,"sortIndex":441,"researcher":20,"roles":962,"affiliations":963,"properties":969},"ec28d3e2-d7a8-4245-bcf8-1937f6328792",[121],[964],{"id":20,"sortIndex":21,"affiliation":965,"properties":20},{"id":907,"createTime":908,"updateTime":908,"relativeEntities":966,"slug":20,"properties":967,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":968},{"VI":912},{"title":970},{"VI":971},"Ruthvik Katuri",{"id":973,"sortIndex":21,"researcher":20,"roles":974,"affiliations":975,"properties":985},"491f75e1-c5bb-41ca-a95e-fa249af23069",[121],[976],{"id":20,"sortIndex":21,"affiliation":977,"properties":20},{"id":978,"createTime":979,"updateTime":979,"relativeEntities":980,"slug":981,"properties":982,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"3b68181d-123c-429b-9fdc-6c64848f9033","2024-04-08T00:20:07.562+00:00",[],"School-of-Pharmacy-and-Technology-Management-SVKM-s-NMIMS-Babulde-Shirpur-India",{"title":983},{"VI":984},"School of Pharmacy and Technology Management, SVKM’s NMIMS, Babulde, Shirpur, India",{"title":986},{"VI":987},"Ravindra Babu Pingili",{"id":989,"sortIndex":534,"researcher":20,"roles":990,"affiliations":991,"properties":997},"13382bb0-2073-4490-9d04-d1cc3076efa1",[121],[992],{"id":20,"sortIndex":21,"affiliation":993,"properties":20},{"id":907,"createTime":908,"updateTime":908,"relativeEntities":994,"slug":20,"properties":995,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":996},{"VI":912},{"title":998},{"VI":999},"Vijayalakshmi Rachamsetty",{"url":20,"publisher":1001,"properties":20},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1002,"slug":10,"properties":1003,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1007,"manageAffiliations":1008,"indexDatabases":1009,"url":20,"thumbnailPath":20,"statistic":1017,"gsStatistic":20,"type":92,"analyzePriority":20},[],{"issn":1004,"title":1005,"url":1006},{"VOID":13},{"EN":15},{"VOID":17},[],[],[1010],{"id":44,"indexDatabase":1011,"url":59,"indexYears":20,"academicFieldIds":1016,"indexDatabaseRanking":20},{"id":46,"createTime":47,"updateTime":48,"relativeEntities":1012,"label":1013,"description":1014,"key":55,"publicationTags":1015,"standard":20},[],{"EN":51,"VI":51},{"VI":53,"EN":54},[57,58],[61],{"impactFactor":21,"impactFactorByYear":1018,"i10Index":68,"i10IndexLast5Year":69,"totalPublication":70,"totalPublicationByYear":1019,"totalCitation":80,"totalCitationByYear":1020,"totalCitationPerPublication":86,"totalCitationPerPublicationByYear":1021,"hindexLast5Year":68,"hindex":68},{"2020":64,"2021":65,"2022":66,"2023":67},{"2015":72,"2016":72,"2017":69,"2018":73,"2019":74,"2020":75,"2021":76,"2022":77,"2023":78,"2024":79},{"2019":82,"2020":83,"2021":84,"2022":85},{"2019":88,"2020":89,"2021":90,"2022":91},"2023-04-17",2023,{"id":1025,"createTime":1026,"updateTime":1027,"relativeEntities":1028,"slug":1029,"properties":1030,"entityType":112,"verifyStatus":113,"verifyTime":1027,"verifyNote":115,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":1039,"fullTextUrl":20,"authors":1040,"publicationType":151,"publisherRelationship":1068,"citationCount":20,"citationInfo":20,"publishDate":1095,"publishYear":1096,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":20,"isForceReanalyzing":181},"fe741084-db55-49a8-ac48-813085e2b054","2024-02-09T09:40:54.420+00:00","2025-02-11T23:36:58.795+00:00",[],"Synthesis-and-in-vitro-antimicrobial-activity-of-new-steroidal-hydrazone-derivatives",{"references":1031,"abstract":1033,"title":1035,"doi":1037},{"VOID":1032},"Rollas S, Kucukguzel SG (2007) Biological activities of hydrazone derivatives. Molecules 12:1910–1939\nSubhashini NJP, Janaki P, Bhadraiah B (2017) Synthesis of hydrazone derivatives of benzofuran and their antibacterial and antifungal activity. Russ J Gen Chem 87:2021–2026\nSridhar KS, Pandeya SN, Stables JP, Atmakuru R (2002) Anticonvulsant activity of hydrazones, Schiff and Mannich bases of isatin derivatives. Eur J Pharm Sci 16:129–132\nDebnatha U, Mukherjee S, Joardar N, Sinha BS, JanaMisra KAK (2019) Aryl quinolinyl hydrazone derivatives as anti-inflammatory agents that inhibit TLR4 activation in the macrophages. Eur J Pharm Sci 134:102–115\nKumar P, Kadyan K, Duhan M, Sindhu J, Singh V, Singh B, Kumar S (2017) Design, synthesis, conformational and molecular docking study of some novel acyl hydrazone based molecular hybrids as antimalarial and antimicrobial agents. Chem Cent J 11:115\nNogueira TM, Cruz LS, Lourenço M, Nora de Souza MV (2019) Design, synthesis and anti-tuberculosis activity of hydrazones and N-acylhydrazones containing vitamin b6 and different heteroaromatic nucleus. Lett Drug Des Discov 16:7\nSingh V, Srivastava VK, Palit G, Shanker K (1992) Coumarin congeners as antidepressants. Arzneim-Forsch Drug Res 42(8):993–996\nGan C, Liu L, Cui J, Liu Z, Shi H, Lin Q, Sheng H, Yang C, Huang Y (2017) Synthesis of some steroidal derivatives with side chain of 20- and 22-hydrazone aromatic hetero cycles and their antiproliferative activity. Med Chem 13(4):375–383\nLoncle C, Brunel JM, Vidal N, Dherbomez M, Letourneux Y (2004) Synthesis and antifungal activity of cholesterol-hydrazone derivatives. Eur J Med Chem 39:1067–1071\nVisbal G, San-Blas G, Maldonado A, Alvarez-Aular A, Capparelli MV, Murgich J (2011) Synthesis, in vitro antifungal activity and mechanism of action of four sterol hydrazone analogues against the dimorphic fungus Paracoccidioides brasiliensis. Steroids 76:1069–1081\nKhan SA, Kumar P, Joshi R, Iqbal PF, Saleem K (2008) Synthesis and in vitro antibacterial activity of new steroidal thiosemicarbazone derivatives. Eur J Med Chem 43(9):2029–2034\nGan C, Cui J, Su S, Lin Q, Jia L, Fan L, Huang Y (2014) Synthesis and antiproliferative activity of some steroidal thiosemicarbazones, semicarbazones and hydrozones. Steroids 87:99–107\nMerlani MI, Kemertelidze EP, Papadopoulos K, Men’shova NI (2004) Some derivatives of 5α ketosteroid hydrazones: synthesis from tigogenin and antituberculosis activity. Russ J Bioorgan Chem 30(5):497–501\nNadaraia NS, Onashvili EO, Kakhabrishvili ML, Barbakadze NN, Sylla B, Pichette A (2016) Synthesis and antiviral activity of several N-containing 5α-steroids. Chem Nat Compd 52(5):853–855\nNadaraia NS, Barbakadze NN, Kakhabrishvili ML, Sylla B, Pichette A, Makhmudov US (2018) Synthesis and biological activity of several modified 5α-androstanolone derivatives. Chem Nat Compd 54(2):310–314\nWang HJ, Bu M, Wang J, Liu L, Zhang S (2019) Synthesis and biological evaluation of novel steroidal 5α, 8α-endoperoxide steroidal derivatives with aromatic hydrazone side chain as potential anticancer agents. Russ J Bioorg Chem 45:585–590\nDhingra N, Bhardwaj TR, Mehta N, Mukhopadhyay T, Kumar A, Kumar M (2010) Synthesis, antiproliferative, acute toxicity and assessment of antiandrogenic activities of some newly synthesized steroidal lactams. Eur J Med Chem 45:2229–2236\nHuang Y, Cui J, Zheng Q, Zeng C, Chen Q, Zhou A (2012) 6-Hydroximino-4-aza-Ahomo-cholest-3-one and related analogue as a potent introducer of apoptosis in cancer cells. Steroids 77:829–834\nDuha CY, Loa IW, Wang SK, Dai CF (2007) New cytotoxic steroids from the soft coral Clavulariaviridis. Steroids 72:573–579\nMalika IO, Maurice S (2006) Recent advances in thiasteroids chemistry. Steroids 71:1025–1044\nHanson JR (2006) Steroids: partial synthesis in medicinal chemistry. Nat Prod Rep 23:100–107\nChen SJ, Cui JG, Li Y, Fan LH (2011) Recent advance of steroidal hydrazone with biological activities. Chin J Org Chem 31(2):187–192\nCui J, Liu L, Zhao D, Gan C, Huang X, Xiao Q, Qi B, Yang L, Huang Y (2015) Synthesis, characterization and antitumor activities of some steroidal derivatives with side chain of 17-hydrazone aromatic heterocycle. Steroids 95:32–38\nCui JG, Liu L, Gan CF, Xiao Q (2014) Synthesis and biological activity of steroids bearing aromatic rings and heterocycles. Prog Chem 26(2\u002F3):320–333\nXu H, Su X, Liu XQ, Zhang KP, Hou Z, Guo C (2019) Design, synthesis and biological evaluation of novel semicarbazone-selenochroman-4-ones hybrids as potent antifungal agents. Bioorg Med Chem Lett 29:126726\nStulov SV, Misharin AYu (2013) Synthesis of steroids with nitrogen-containing substituent’s in ring D. Chem Heterocycl Compd 48(10):1431–1472\nLi C, Qiu W, Yang Z, Luo J, Yang F, Liu M, Xie J, Tang J (2010) Stereoselective synthesis of some methyl-substituted steroid hormones and their in vitro cytotoxic activity against human gastric cancer cell line MGC-803. Steroids 75:859–869\nSchroder NA (1952) The effect of 1-hydrasinophthalasine in hypertension. Circulation 5(1):28–37\nSousa C, Freire C, De Castro B (2003) Synthesis and characterization of benzo-15-crown-5 ethers with appended N2O Schiff bases. Molecules 8:894–900\nKajal A, Bala S, Kamboj S, Saini V (2014) Synthesis, characterization, and computational studies on phthalic anhydride-based benzylidene-hydrazide derivatives as novel, potential anti-inflammatory agents. Med Chem Res 23:2676–2689\nCikla P, Tatar E, Kucukguzel I, Sahin F, Yurdakul D, Basu A, Krishnan R, KNicholsKaushik-BasuKucukguzel DBNSG (2013) Synthesis and characterization of flurbiprofen hydrazide derivatives as potential anti-HCV, anticancer and antimicrobial agents. Med Chem Res 22:5685–5699\nBedia KK, Oruc-Emre EE, Unsalan S, Rollas S (2009) Synthesis and anticancer activity of new hydrazide-hydrazones and their Pd(II) complexes. Med Chem Res 18:277–286\nAllah HMF, Soliman R (1987) Synthesis and spectra of some triazolo and triazin phthalazines of possible hypotensive activity. J Hetero Cycl Chem 24:667–671\nRasras AJM, Al-Tel TH, Al-Aboudi AF, Al-Qawasmeh RA (2010) Synthesis and antimicrobial activity of cholic acid hydrazone analogues. Eur J Med Chem 45:2307–2313\nMohareb RM, Al-Omran F (2012) Novel synthesis of hydrazide-hydrazone, pyrazole, pyridine, thiazole, thiophene derivatives and their cytotoxicity evaluations. Steroids 77:1551–1559\nNadaraia NS, Barbakadze NN, Kakhabrishvili ML, Mshvildadze VD (2019) Synthesis and biological activity of hydrazones of 5α-steroids. Res J Pharm Biol Chem Sci 10(1):238–242\nNadaraia NS, Barbakadze NN, Mshvildadze VD, Sylla B, Legault J, Pichette A (2020) Synthesis and cytotoxicity of epiandrosterone hydrazones. Chem Nat Compd 56(2):274–277\nMuafia J, Muhammad IC, Ghulam AM, Khondaker MR, Umer R, Khan HU, Arshiab F, Abdul S (2018) Synthesis, pharmacological evaluation and docking studies of progesterone and testosterone derivatives as anticancer agents. Steroids 136:22–31\nZivkovic MB, Matic IZ, Rodic MV, Novakovic IT, Sladic DM, Krstic NM (2016) Synthesis, characterization and in vitro cytotoxic activities of new steroidal thiosemicarbazones and thiadiazolines. RSC Adv 6:34312–34333\nWiegand I, Hilpert K, Hancock REW (2008) Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. Nat Protoc 3(2):165",{"EN":1034},"For many years, various drugs have been used for the treatment of infectious diseases but some bacterial microorganisms have induced resistance to several drugs. In a search of new antimicrobial agents, a series of new steroidal hydrazones were designed and synthesized. The structures of the compounds were established based on the spectral data. The in vitro antimicrobial activity of some newly synthesized compounds against bacteria and fungi was studied. New compounds showed better or similar antimicrobial activity. Designing more efficient steroidal hydrazones from ketosteroid based on the current study may successfully lead to the development of antimicrobial agent. \n                  \n                    \n                      \n                    \n                  \n                ",{"EN":1036},"Synthesis and in vitro antimicrobial activity of new steroidal hydrazone derivatives",{"VOID":1038},"10.1186\u002Fs43094-021-00391-4","https:\u002F\u002Ffjps.springeropen.com\u002Farticles\u002F10.1186\u002Fs43094-021-00391-4",[1041,1056],{"id":1042,"sortIndex":21,"researcher":20,"roles":1043,"affiliations":1044,"properties":1053},"90b53e87-ed69-48c3-bcb8-0a6c26118ce1",[121],[1045],{"id":20,"sortIndex":21,"affiliation":1046,"properties":20},{"id":1047,"createTime":1048,"updateTime":1048,"relativeEntities":1049,"slug":20,"properties":1050,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"e1b0b989-bf6a-46b8-8a67-9a30572d81e7","2024-02-09T09:40:54.439+00:00",[],{"title":1051},{"VI":1052},"Parul Institute of Applied Science, Parul University, Vadodara, India",{"title":1054},{"VI":1055},"Shailesh Mistry",{"id":1057,"sortIndex":137,"researcher":20,"roles":1058,"affiliations":1059,"properties":1065},"7a3b3f9a-dd78-4aee-91f5-cb36b679aac2",[121],[1060],{"id":20,"sortIndex":21,"affiliation":1061,"properties":20},{"id":1047,"createTime":1048,"updateTime":1048,"relativeEntities":1062,"slug":20,"properties":1063,"entityType":40,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1064},{"VI":1052},{"title":1066},{"VI":1067},"Akhilesh Kumar Singh",{"url":1039,"publisher":1069,"properties":1090},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1070,"slug":10,"properties":1071,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1075,"manageAffiliations":1076,"indexDatabases":1077,"url":20,"thumbnailPath":20,"statistic":1085,"gsStatistic":20,"type":92,"analyzePriority":20},[],{"issn":1072,"title":1073,"url":1074},{"VOID":13},{"EN":15},{"VOID":17},[],[],[1078],{"id":44,"indexDatabase":1079,"url":59,"indexYears":20,"academicFieldIds":1084,"indexDatabaseRanking":20},{"id":46,"createTime":47,"updateTime":48,"relativeEntities":1080,"label":1081,"description":1082,"key":55,"publicationTags":1083,"standard":20},[],{"EN":51,"VI":51},{"VI":53,"EN":54},[57,58],[61],{"impactFactor":21,"impactFactorByYear":1086,"i10Index":68,"i10IndexLast5Year":69,"totalPublication":70,"totalPublicationByYear":1087,"totalCitation":80,"totalCitationByYear":1088,"totalCitationPerPublication":86,"totalCitationPerPublicationByYear":1089,"hindexLast5Year":68,"hindex":68},{"2020":64,"2021":65,"2022":66,"2023":67},{"2015":72,"2016":72,"2017":69,"2018":73,"2019":74,"2020":75,"2021":76,"2022":77,"2023":78,"2024":79},{"2019":82,"2020":83,"2021":84,"2022":85},{"2019":88,"2020":89,"2021":90,"2022":91},{"volume":1091,"pages":1093},{"VOID":1092},"8",{"VOID":1094},"1-10","2022-01-06",2022]