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Independent predictors of malignancy were identified and their performance were evaluated. Seven radiomics signatures (RSs) using maximum relevance minimum redundancy (mRMR), and the least absolute shrinkage selection operator (LASSO) algorithm were established. The radiomics nomograms, comprising the clinical model and the RS algorithms were built: one based on pre-contrast MRI (RNWOC); the other based on pre-contrast and post-contrast MRI (RNWC). The performances of the models were evaluated with area under the curve (AUC), calibration, and decision curve analysis (DCA) respectively.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>The efficacy of the clinical model (AUC=0.81) of RNWC was higher than that of the model (AUC=0.76) of RNWOC in the test set. There was no significant difference in the AUC of radiomic algorithms in the test set. The RS-T1T2 (AUC=0.74) and RS-T1T2T1C (RSWC, AUC=0.81) achieved a good distinction efficacy in the test set. The RNWC and the RNWOC showed excellent distinction (AUC=0.89 and 0.82 respectively) in the test set. The DCA of the nomograms showed better clinical usefulness than the clinical models and radiomics signatures.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>The radiomics nomograms combining the clinical model and RS can be accurately, safely and efficiently used to distinguish between benign and malignant sinonasal tumors.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":123},"Radiomics Nomograms Based on Multi-Parametric MRI for Preoperative Differential Diagnosis of Malignant and Benign Sinonasal Tumors: A Two-Centre Study",{"VOID":125},"34012922",{"VOID":127},"10.3389\u002Ffonc.2021.659905","PUBLICATION","VERIFIED","Auto 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by extrapleural pneumonectomy and radiation for malignant pleural mesothelioma, J Clin Oncol, 27, 3007, 10.1200\u002FJCO.2008.20.3943",{"doi":3067},"10.1200\u002FJCO.2008.20.3943",{"id":23,"text":3069,"url":23,"identifiers":3070},"Nelson, 2017, Long-term survival outcomes of cancer-directed surgery for malignant pleural mesothelioma: propensity score matching analysis, J Clin Oncol, 35, 3354, 10.1200\u002FJCO.2017.73.8401",{"doi":3071},"10.1200\u002FJCO.2017.73.8401",{"id":23,"text":3073,"url":23,"identifiers":3074},"Vogelzang, 2003, Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma, J Clin Oncol, 21, 2636, 10.1200\u002FJCO.2003.11.136",{"doi":3075},"10.1200\u002FJCO.2003.11.136",{"id":23,"text":3077,"url":23,"identifiers":3078},"Ujiie, 2015, The tumoral and stromal immune microenvironment in malignant pleural mesothelioma: a comprehensive analysis reveals prognostic immune markers, Oncoimmunol, 4, e1009285, 10.1080\u002F2162402X.2015.1009285",{"doi":3079},"10.1080\u002F2162402X.2015.1009285",{"id":23,"text":3081,"url":23,"identifiers":3082},"Batirel, 2017, Extrapeural pneumonectomy (EPP) vs. pleurectomy decorication (P\u002FD), Ann Transl Med, 5, 232, 10.21037\u002Fatm.2017.03.82",{"doi":3083},"10.21037\u002Fatm.2017.03.82",{"id":23,"text":3085,"url":23,"identifiers":3086},"Eguchi, 2017, Cancer antigen profiling for malignant pleural mesothelioma immunotherapy: expression and coexpression of mesothelin, cancer antigen 125, and Wilms tumor 1, Oncotarget, 8, 77872, 10.18632\u002Foncotarget.20845",{"doi":3087},"10.18632\u002Foncotarget.20845",{"id":23,"text":3089,"url":23,"identifiers":3090},"2015, WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart",{},{"id":23,"text":3092,"url":23,"identifiers":3093},"Krishnamurti, 2017, Tumor-infiltrating lymphocytes are significantly associated with better overall survival and disease-free survival in triple-negative but not estrogen receptor-positive breast cancers, Hum Pathol, 64, 7, 10.1016\u002Fj.humpath.2017.01.004",{"doi":3094},"10.1016\u002Fj.humpath.2017.01.004",{"id":23,"text":3096,"url":23,"identifiers":3097},"Suzuki, 2011, Chronic inflammation in tumor stroma is an independent predictor of prolonged survival in epithelioid malignant pleural mesothelioma patients, Cancer Immunol. Immunother, 60, 1721, 10.1007\u002Fs00262-011-1073-8",{"doi":3098},"10.1007\u002Fs00262-011-1073-8",{"id":23,"text":3100,"url":23,"identifiers":3101},"Ghebrehiwet, 1996, Identification of functional domains on gClQ-R, a cell surface protein that binds to the globular “heads” of C1Q, using monoclonal antibodies and synthetic peptides, Hybridoma, 15, 333, 10.1089\u002Fhyb.1996.15.333",{"doi":3102},"10.1089\u002Fhyb.1996.15.333",{"id":23,"text":3104,"url":23,"identifiers":3105},"Kadota, 2012, A nuclear grading system is a strong predictor of survival in epitheloid diffuse malignant pleural mesothelioma, Mod Pathol, 25, 260, 10.1038\u002Fmodpathol.2011.146",{"doi":3106},"10.1038\u002Fmodpathol.2011.146",{"id":23,"text":3108,"url":23,"identifiers":3109},"Penault-Llorca, 2009, Ki67 expression and docetaxel efficacy in patients with estrogen receptor–positive breast cancer, J Clin Oncol, 27, 2809, 10.1200\u002FJCO.2008.18.2808",{"doi":3110},"10.1200\u002FJCO.2008.18.2808",{"id":23,"text":3112,"url":23,"identifiers":3113},"Enomoto, 2016, Impact of biomarker changes during neoadjuvant chemotherapy for clinical response in patients with residual breast cancers, Inter J Clin Oncol, 21, 254, 10.1007\u002Fs10147-015-0897-1",{"doi":3114},"10.1007\u002Fs10147-015-0897-1",{"id":23,"text":3116,"url":23,"identifiers":3117},"Yerushalmi, 2010, Ki67 in breast cancer: prognostic and predictive potential, Lancet Oncol, 11, 174, 10.1016\u002FS1470-2045(09)70262-1",{"doi":3118},"10.1016\u002FS1470-2045(09)70262-1",{"id":23,"text":3120,"url":23,"identifiers":3121},"Ghanim, 2015, Ki67 index is an independent prognostic factor in epithelioid but not in non-epithelioid malignant pleural mesothelioma: a multicenter study, Brit J Cancer, 112, 783, 10.1038\u002Fbjc.2015.9",{"doi":3122},"10.1038\u002Fbjc.2015.9",{"id":23,"text":3124,"url":23,"identifiers":3125},"Chen, 1994, Human T cells express specific binding sites for C1q. Role in T cell activation and proliferation, J Immunol, 153, 1430, 10.4049\u002Fjimmunol.153.4.1430",{"doi":3126},"10.4049\u002Fjimmunol.153.4.1430",{"id":23,"text":3128,"url":23,"identifiers":3129},"Agostinis, 2017, Complement protein C1q binds to hyaluronic acid in the malignant pleural mesothelioma microenvironment and promotes tumor growth, Front Immunol, 10.3389\u002Ffimmu.2017.01559",{"doi":3130},"10.3389\u002Ffimmu.2017.01559",{"id":23,"text":3132,"url":23,"identifiers":3133},"Cortes-Dericks, 2017, CD44 and its ligand hyaluronan as potential biomarkers in malignant pleural mesothelioma: evidence and perspectives, Respir Res, 18, 58, 10.1186\u002Fs12931-017-0546-5",{"doi":3134},"10.1186\u002Fs12931-017-0546-5",{"id":23,"text":3136,"url":23,"identifiers":3137},"Creaney, 2013, Pleural effusion hyaluronic acid as a prognostic marker in pleural mesothelioma, Lung Cancer., 82, 491, 10.1016\u002Fj.lungcan.2013.09.016",{"doi":3138},"10.1016\u002Fj.lungcan.2013.09.016",{"id":23,"text":3140,"url":23,"identifiers":3141},"Knudson, 1998, The role of CD44 as a cell surface hyaluronan receptor during tumor invasion of connective tissue, Front Biosci, 3, d604, 10.2741\u002FA305",{"doi":3142},"10.2741\u002FA305",{"id":23,"text":3144,"url":23,"identifiers":3145},"Ghebrehiwet, 2004, cC1qR (calreticulin) and gC1qR (p33): ubiquitously expressed multiligand binding cellular proteins involved in inflammation and infection, Mol Immunol, 41, 73, 10.1016\u002FS0161-5890(04)00076-8",{"doi":3146},"10.1016\u002FS0161-5890(04)00076-8",{"id":3148,"createTime":3149,"updateTime":3149,"relativeEntities":3150,"slug":3151,"properties":3152,"entityType":128,"verifyStatus":129,"verifyTime":3149,"verifyNote":130,"syncStatus":22,"languages":3164,"translateLanguages":23,"viewCount":24,"primaryUrl":3165,"fullTextUrl":23,"authors":3166,"publicationType":271,"publisherRelationship":3466,"citationCount":3337,"citationInfo":3500,"publishDate":23,"publishYear":23,"citationAnalyzeStatus":22,"lastCitationAnalyze":23,"indexDatabases":23,"openAccess":23,"references":3502,"isForceReanalyzing":469},"62903da0-fea5-47d8-b2f3-272a9585883a","2024-10-05T22:27:47.510+00:00",[],"Safety-of-Rapid-Daratumumab-Infusion-A-Retrospective-Multicenter-Real-Life-Analysis-on-134-Patients-With-Multiple-Myeloma",{"keywords":3153,"openalex":3154,"abstract":3156,"title":3158,"pm":3160,"doi":3162},{},{"VOID":3155},"W4220655725",{"EN":3157},"\u003Cjats:sec>\u003Cjats:title>Background\u003C\u002Fjats:title>\u003Cjats:p>The anti-CD38 monoclonal antibody daratumumab is the backbone of most anti-multiple myeloma (MM) regimens. To mitigate the risk of infusion-related reactions (IRRs), intravenous daratumumab administration requires 7 hours for the first infusion and 3.5-4 hours thereafter, thus making daratumumab-containing regimens burdensome for patients and health care resources. Preliminary data suggest that a rapid (90-minute) infusion of daratumumab is safe and does not increase IRRs. The rapid schedule was adopted by our centers since 2019.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>We conducted an observational multi-center, real-life study to assess the safety of rapid daratumumab infusion protocol from the third administration in relapsed MM patients receiving daratumumab alone or in combination with lenalidomide-dexamethasone or bortezomib-dexamethasone. The primary endpoint was the safety of the rapid infusion protocol, particularly in terms of IRRs.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>A total of 134 MM patients were enrolled. IRRs occurred in 7 (5%) patients and were mostly mild (6\u002F7 of grade 1-2), with only 1 patient experiencing a grade 3 IRR. Due to the IRRs, 5 (3.7%) patients discontinued the rapid infusions and resumed daratumumab at the standard infusion rate, while 1 patient permanently discontinued daratumumab. In 4\u002F7 patients (57%), IRRs occurred while resuming rapid daratumumab infusions after a temporary interruption (2-4 months). No other adverse event was considered related to the rapid infusion protocol.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>Our findings confirmed the safety of rapid daratumumab infusions starting from the third administration. In case of prolonged daratumumab interruption, it is advisable to resume infusions at the standard rate (3.5 hours) before switching to the rapid infusion.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":3159},"Safety of Rapid Daratumumab Infusion: A Retrospective, Multicenter, Real-Life Analysis on 134 Patients With Multiple 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