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Because of the relatively high recurrence rate of OC, it is crucial to understand the associated mechanisms of drug resistance and to discover potential target for rational targeted therapy. Cell death is a genetically determined process. Active and orderly cell death is prevalent during the development of living organisms and plays a critical role in regulating life homeostasis. Ferroptosis, a novel type of cell death discovered in recent years, is distinct from apoptosis and necrosis and is mainly caused by the imbalance between the production and degradation of intracellular lipid reactive oxygen species triggered by increased iron content. Necroptosis is a regulated non-cysteine protease–dependent programmed cell necrosis, morphologically exhibiting the same features as necrosis and occurring \u003Cjats:italic>via\u003C\u002Fjats:italic> a unique mechanism of programmed cell death different from the apoptotic signaling pathway. Pyroptosis is a form of programmed cell death that is characterized by the formation of membrane pores and subsequent cell lysis as well as release of pro-inflammatory cell contents mediated by the abscisin family. Studies have shown that ferroptosis, necroptosis, and pyroptosis are involved in the development and progression of a variety of diseases, including tumors. In this review, we summarized the recent advances in ferroptosis, necroptosis, and pyroptosis in the occurrence, development, and therapeutic potential of OC.\u003C\u002Fjats:p>",{"EN":1460},"Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian 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10.1073\u002Fpnas.1906346116",{"doi":4166},"10.1073\u002Fpnas.1906346116",{"id":4168,"createTime":4169,"updateTime":4169,"relativeEntities":4170,"slug":4171,"properties":4172,"entityType":118,"verifyStatus":119,"verifyTime":4169,"verifyNote":120,"languages":4183,"translateLanguages":23,"viewCount":24,"primaryUrl":4184,"fullTextUrl":23,"authors":4185,"publicationType":280,"publisherRelationship":4416,"citationCount":4461,"citationInfo":4462,"publishDate":23,"publishYear":23,"citationAnalyzeStatus":22,"lastCitationAnalyze":23,"indexDatabases":4466,"openAccess":23,"references":4467,"isForceReanalyzing":436},"0d0e5f5d-4397-4245-be49-295da6926cf4","2025-02-11T01:31:59.980+00:00",[],"Bone-Marrow-Derived-Mesenchymal-Stromal-Cell-Therapy-in-Severe-COVID-19-Preliminary-Results-of-a-Phase-I-II-Clinical-Trial",{"openalex":4173,"abstract":4175,"title":4177,"pm":4179,"doi":4181},{"VOID":4174},"W4283803740",{"EN":4176},"\u003Cjats:sec>\u003Cjats:title>Background\u003C\u002Fjats:title>\u003Cjats:p>Treatment of acute respiratory distress syndrome (ARDS) associated with COronaVIrus Disease-2019 (COVID-19) currently relies on dexamethasone and supportive mechanical ventilation, and remains associated with high mortality. Given their ability to limit inflammation, induce immune cells into a regulatory phenotype and stimulate tissue repair, mesenchymal stromal cells (MSCs) represent a promising therapy for severe and critical COVID-19 disease, which is associated with an uncontrolled immune-mediated inflammatory response.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>In this phase I-II trial, we aimed to evaluate the safety and efficacy of 3 intravenous infusions of bone marrow (BM)-derived MSCs at 3-day intervals in patients with severe COVID-19. All patients also received dexamethasone and standard supportive therapy. Between June 2020 and September 2021, 8 intensive care unit patients requiring supplemental oxygen (high-flow nasal oxygen in 7 patients, invasive mechanical ventilation in 1 patient) were treated with BM-MSCs. We retrospectively compared the outcomes of these MSC-treated patients with those of 24 matched control patients. Groups were compared by paired statistical tests.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>MSC infusions were well tolerated, and no adverse effect related to MSC infusions were reported (one patient had an ischemic stroke related to aortic endocarditis). Overall, 3 patients required invasive mechanical ventilation, including one who required extracorporeal membrane oxygenation, but all patients ultimately had a favorable outcome. Survival was significantly higher in the MSC group, both at 28 and 60 days (100% vs 79.2%, p = 0.025 and 100% vs 70.8%, p = 0.0082, respectively), while no significant difference was observed in the need for mechanical ventilation nor in the number of invasive ventilation-free days, high flow nasal oxygenation-free days, oxygen support-free days and ICU-free days. MSC-treated patients also had a significantly lower day-7 D-dimer value compared to control patients (median 821.0 µg\u002FL [IQR 362.0-1305.0] vs 3553 µg\u002FL [IQR 1155.0-6433.5], p = 0.0085).\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>BM-MSC therapy is safe and shows very promising efficacy in severe COVID-19, with a higher survival in our MSC cohort compared to matched control patients. These observations need to be confirmed in a randomized controlled trial designed to demonstrate the efficacy of BM-MSCs in COVID-19 ARDS.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Clinical Trial Registration\u003C\u002Fjats:title>\u003Cjats:p>(\u003Cjats:uri>www.ClinicalTrials.gov\u003C\u002Fjats:uri>), identifier NCT04445454\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":4178},"Bone Marrow-Derived Mesenchymal Stromal Cell Therapy in Severe COVID-19: Preliminary Results of a Phase I\u002FII Clinical 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Neutrophils are professional phagocytes of the innate immune system that are critical in pathogen handling. Neutrophil responses to infection are dysregulated in diabetes, predominantly mediated by persistent hyperglycaemia; the chief biochemical abnormality in T1D and T2D. Therapeutically enhancing host immunity in diabetes to improve infection resolution is an expanding area of research. Individuals with diabetes are also at an increased risk of severe coronavirus disease 2019 (COVID-19), highlighting the need for re-invigorated and urgent focus on this field. The aim of this review is to explore the breadth of previous literature investigating neutrophil function in both T1D and T2D, in order to understand the complex neutrophil phenotype present in this disease and also to focus on the development of new therapies to improve aberrant neutrophil function in diabetes. Existing literature illustrates a dual neutrophil dysfunction in diabetes. Key pathogen handling mechanisms of neutrophil recruitment, chemotaxis, phagocytosis and intracellular reactive oxygen species (ROS) production are decreased in diabetes, weakening the immune response to infection. However, pro-inflammatory neutrophil pathways, mainly neutrophil extracellular trap (NET) formation, extracellular ROS generation and pro-inflammatory cytokine generation, are significantly upregulated, causing damage to the host and perpetuating inflammation. Reducing these proinflammatory outputs therapeutically is emerging as a credible strategy to improve infection resolution in diabetes, and also more recently COVID-19. Future research needs to drive forward the exploration of novel treatments to improve infection resolution in T1D and T2D to improve patient morbidity and mortality.\u003C\u002Fjats:p>",{"EN":5421},"A Bittersweet Response to Infection in Diabetes; Targeting Neutrophils to Modify Inflammation and Improve Host Immunity",{"VOID":5423},"34149714",{"VOID":5425},"10.3389\u002Ffimmu.2021.678771",[122],"https:\u002F\u002Fwww.frontiersin.org\u002Farticles\u002F10.3389\u002Ffimmu.2021.678771\u002Ffull",[5429,5446,5473,5496,5513],{"id":5430,"sortIndex":24,"researcher":23,"roles":5431,"affiliations":5432,"properties":5441},"48c8ff88-1311-4480-8542-774d255db5a1",[],[5433],{"id":5434,"sortIndex":24,"affiliation":5435,"properties":23},"88f8412a-0339-456c-bdcd-6f1af5518f95",{"id":5434,"createTime":23,"updateTime":23,"relativeEntities":5436,"slug":23,"properties":5437,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":5440,"statistic":23},[],{"title":5438},{"VI":5439},"Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom",[],{"title":5442,"openalex":5444},{"EN":5443},"Rebecca Dowey",{"VOID":5445},"A5021731689",{"id":5447,"sortIndex":139,"researcher":23,"roles":5448,"affiliations":5449,"properties":5466},"1fa4f6e2-c4bb-4046-a5d5-7652bd093e6f",[],[5450,5458],{"id":5451,"sortIndex":24,"affiliation":5452,"properties":23},"1bb5cd89-9d51-40b1-aae7-7b966aff3bf5",{"id":5451,"createTime":23,"updateTime":23,"relativeEntities":5453,"slug":23,"properties":5454,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":5457,"statistic":23},[],{"title":5455},{"VI":5456},"Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom",[],{"id":5459,"sortIndex":139,"affiliation":5460,"properties":23},"855acb17-b8fa-40d1-a11b-48df076ea04a",{"id":5459,"createTime":23,"updateTime":23,"relativeEntities":5461,"slug":23,"properties":5462,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":5465,"statistic":23},[],{"title":5463},{"EN":5464},"Sheffield Teaching Hospitals National Health Service (NHS) Foundation Trust, Sheffield, United Kingdom",[],{"orcid":5467,"title":5469,"openalex":5471},{"VOID":5468},"https:\u002F\u002Forcid.org\u002F0000-0002-5648-0539",{"EN":5470},"Ahmed Iqbal",{"VOID":5472},"A5061943349",{"id":5474,"sortIndex":180,"researcher":23,"roles":5475,"affiliations":5476,"properties":5489},"7e75f614-1d69-4a25-828f-6c8ded4f74ae",[],[5477,5483],{"id":5451,"sortIndex":24,"affiliation":5478,"properties":23},{"id":5451,"createTime":23,"updateTime":23,"relativeEntities":5479,"slug":23,"properties":5480,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":5482,"statistic":23},[],{"title":5481},{"VI":5456},[],{"id":5459,"sortIndex":139,"affiliation":5484,"properties":23},{"id":5459,"createTime":23,"updateTime":23,"relativeEntities":5485,"slug":23,"properties":5486,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":5488,"statistic":23},[],{"title":5487},{"EN":5464},[],{"orcid":5490,"title":5492,"openalex":5494},{"VOID":5491},"https:\u002F\u002Forcid.org\u002F0000-0002-2425-9565",{"EN":5493},"Simon Heller",{"VOID":5495},"A5052889466",{"id":5497,"sortIndex":202,"researcher":23,"roles":5498,"affiliations":5499,"properties":5506},"9adca8c2-ac71-4f1c-921c-e78e78e12749",[],[5500],{"id":5459,"sortIndex":24,"affiliation":5501,"properties":23},{"id":5459,"createTime":23,"updateTime":23,"relativeEntities":5502,"slug":23,"properties":5503,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":5505,"statistic":23},[],{"title":5504},{"EN":5464},[],{"orcid":5507,"title":5509,"openalex":5511},{"VOID":5508},"https:\u002F\u002Forcid.org\u002F0000-0001-9750-8975",{"EN":5510},"Ian Sabroe",{"VOID":5512},"A5032808351",{"id":5514,"sortIndex":230,"researcher":23,"roles":5515,"affiliations":5516,"properties":5523},"e76110e8-3ef5-4bd0-8367-6c9f59dc2cb7",[],[5517],{"id":5434,"sortIndex":24,"affiliation":5518,"properties":23},{"id":5434,"createTime":23,"updateTime":23,"relativeEntities":5519,"slug":23,"properties":5520,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":5522,"statistic":23},[],{"title":5521},{"VI":5439},[],{"orcid":5524,"title":5526,"openalex":5528},{"VOID":5525},"https:\u002F\u002Forcid.org\u002F0000-0001-6133-9372",{"EN":5527},"Lynne R. 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