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Patients with HF who are resistant to medication and device therapy are candidates for heart transplantation (HT). However, the shortage of donor hearts is a serious issue. As an alternative to HT, cardiac regenerative therapy using human pluripotent stem cells (hPSCs), such as human embryonic stem cells and induced pluripotent stem cells, is expected to be realized. Differentiation of hPSCs into cardiomyocytes (CMs) is facilitated by mimicking normal heart development. To prevent tumorigenesis after transplantation, it is important to eliminate non-CMs, including residual hPSCs, and select only CMs. Among many CM selection systems, metabolic selection based on the differences in metabolism between CMs and non-CMs is favorable in terms of cost and efficacy. Large-scale culture systems have been developed because a large number of hPSC-derived CMs (hPSC-CMs) are required for transplantation in clinical settings. In large animal models, hPSC-CMs transplanted into the myocardium improved cardiac function in a myocardial infarction model. Although post-transplantation arrhythmia and immune rejection remain problems, their mechanisms and solutions are under investigation. In this manner, the problems of cardiac regenerative therapy are being solved individually. Thus, cardiac regenerative therapy with hPSC-CMs is expected to become a safe and effective treatment for HF in the near future. In this review, we describe previous studies related to hPSC-CMs and discuss the future perspectives of cardiac regenerative therapy using hPSC-CMs.\u003C\u002Fjats:p>",{"EN":103},"The Present State and Future Perspectives of Cardiac Regenerative Therapy Using Human Pluripotent Stem Cells",{"VOID":105},"34957258",{"VOID":107},"10.3389\u002Ffcvm.2021.774389","PUBLICATION","VERIFIED","Auto 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Natl Acad Sci USA., 110, E3281, 10.1073\u002Fpnas.1303669110",{"doi":336},"10.1073\u002Fpnas.1303669110",{"id":23,"text":338,"url":23,"identifiers":339},"Tateno, 2015, Elimination of tumorigenic human pluripotent stem cells by a recombinant lectin-toxin fusion protein, Stem Cell Rep., 4, 811, 10.1016\u002Fj.stemcr.2015.02.016",{"doi":340},"10.1016\u002Fj.stemcr.2015.02.016",{"id":23,"text":342,"url":23,"identifiers":343},"Ben-David, 2013, Immunologic and chemical targeting of the tight-junction protein Claudin-6 eliminates tumorigenic human pluripotent stem cells, Nat Commun., 4, 1992, 10.1038\u002Fncomms2992",{"doi":344},"10.1038\u002Fncomms2992",{"id":23,"text":346,"url":23,"identifiers":347},"Tohyama, 2013, Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes, Cell Stem Cell., 12, 127, 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10.1038\u002Fnature13233",{"doi":483},"10.1038\u002Fnature13233",{"id":23,"text":485,"url":23,"identifiers":486},"Shiba, 2016, Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts, Nature., 538, 388, 10.1038\u002Fnature19815",{"doi":487},"10.1038\u002Fnature19815",{"id":23,"text":489,"url":23,"identifiers":490},"Liu, 2018, Human embryonic stem cell-derived cardiomyocytes restore function in infarcted hearts of non-human primates, Nat Biotechnol., 36, 597, 10.1038\u002Fnbt.4162",{"doi":491},"10.1038\u002Fnbt.4162",{"id":23,"text":493,"url":23,"identifiers":494},"Kawaguchi, 2021, Intramyocardial transplantation of human iPS cell-derived cardiac spheroids improves cardiac function in heart failure animals, JACC Basic Transl Sci., 6, 239, 10.1016\u002Fj.jacbts.2020.11.017",{"doi":495},"10.1016\u002Fj.jacbts.2020.11.017",{"id":23,"text":497,"url":23,"identifiers":498},"Cho, 2017, Neonatal transplantation confers maturation of PSC-derived cardiomyocytes conducive to modeling cardiomyopathy, Cell Rep., 18, 571, 10.1016\u002Fj.celrep.2016.12.040",{"doi":499},"10.1016\u002Fj.celrep.2016.12.040",{"id":23,"text":501,"url":23,"identifiers":502},"Kadota, 2017, In vivo maturation of human induced pluripotent stem cell-derived cardiomyocytes in neonatal and adult rat hearts, Stem Cell Reports., 8, 278, 10.1016\u002Fj.stemcr.2016.10.009",{"doi":503},"10.1016\u002Fj.stemcr.2016.10.009",{"id":23,"text":505,"url":23,"identifiers":506},"Romagnuolo, 2019, Human embryonic stem cell-derived cardiomyocytes regenerate the infarcted pig heart but induce ventricular tachyarrhythmias, Stem Cell Rep., 12, 967, 10.1016\u002Fj.stemcr.2019.04.005",{"doi":507},"10.1016\u002Fj.stemcr.2019.04.005",{"id":23,"text":509,"url":23,"identifiers":510},"Hattan, 2005, Purified cardiomyocytes from bone marrow mesenchymal stem cells produce stable intracardiac grafts in mice, Cardiovasc Res., 65, 334, 10.1016\u002Fj.cardiores.2004.10.004",{"doi":511},"10.1016\u002Fj.cardiores.2004.10.004",{"id":23,"text":513,"url":23,"identifiers":514},"Nakajima, 2015, Gelatin hydrogel enhances the engraftment of transplanted cardiomyocytes and angiogenesis to ameliorate cardiac function after myocardial infarction, PLoS ONE., 10, e0133308, 10.1371\u002Fjournal.pone.0133308",{"doi":515},"10.1371\u002Fjournal.pone.0133308",{"id":23,"text":517,"url":23,"identifiers":518},"Lee, 2018, Prolonged survival of transplanted stem cells after ischaemic injury via the slow release of pro-survival peptides from a collagen matrix, Nat Biomed Eng., 2, 104, 10.1038\u002Fs41551-018-0191-4",{"doi":519},"10.1038\u002Fs41551-018-0191-4",{"id":23,"text":521,"url":23,"identifiers":522},"Tabei, 2019, Development of a transplant injection device for optimal distribution and retention of human induced pluripotent stem cell–derived cardiomyocytes, J Heart Lung Transplant., 38, 203, 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10.1001\u002Fjama.2012.28726",{"doi":547},"10.1001\u002Fjama.2012.28726",{"id":23,"text":549,"url":23,"identifiers":550},"Nakamura, 2021, Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes, Stem Cell Reports, 16, 2473, 10.1016\u002Fj.stemcr.2021.08.005",{"doi":551},"10.1016\u002Fj.stemcr.2021.08.005",{"id":23,"text":553,"url":23,"identifiers":554},"Karbassi, 2020, Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine, Nat Rev Cardiol., 17, 341, 10.1038\u002Fs41569-019-0331-x",{"doi":555},"10.1038\u002Fs41569-019-0331-x",{"id":23,"text":557,"url":23,"identifiers":558},"Lu, 2013, Generating hypoimmunogenic human embryonic stem cells by the disruption of beta 2-microglobulin, Stem Cell Rev Rep., 9, 806, 10.1007\u002Fs12015-013-9457-0",{"doi":559},"10.1007\u002Fs12015-013-9457-0",{"id":23,"text":561,"url":23,"identifiers":562},"Deuse, 2019, Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients, Nat Biotechnol., 37, 252, 10.1038\u002Fs41587-019-0016-3",{"doi":563},"10.1038\u002Fs41587-019-0016-3",{"id":23,"text":565,"url":23,"identifiers":566},"Xu, 2019, Targeted disruption of HLA genes via CRISPR-Cas9 generates iPSCs with enhanced immune compatibility, Cell Stem Cell., 24, 566, 10.1016\u002Fj.stem.2019.02.005",{"doi":567},"10.1016\u002Fj.stem.2019.02.005",{"id":23,"text":569,"url":23,"identifiers":570},"Menasché, 2015, Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report, Eur Heart J., 36, 2011, 10.1093\u002Feurheartj\u002Fehv189",{"doi":571},"10.1093\u002Feurheartj\u002Fehv189",false,{"id":574,"createTime":575,"updateTime":575,"relativeEntities":576,"slug":577,"properties":578,"entityType":108,"verifyStatus":109,"verifyTime":590,"verifyNote":110,"syncStatus":22,"languages":591,"translateLanguages":23,"viewCount":24,"primaryUrl":592,"fullTextUrl":23,"authors":593,"publicationType":226,"publisherRelationship":900,"citationCount":929,"citationInfo":930,"publishDate":23,"publishYear":23,"citationAnalyzeStatus":22,"lastCitationAnalyze":23,"indexDatabases":23,"openAccess":23,"references":934,"isForceReanalyzing":572},"0d267e58-0650-4ccb-b541-ca0594d38295","2025-02-01T21:55:49.980+00:00",[],"Case-report-Transplantation-of-human-induced-pluripotent-stem-cell-derived-cardiomyocyte-patches-for-ischemic-cardiomyopathy",{"keywords":579,"openalex":580,"abstract":582,"title":584,"pm":586,"doi":588},{},{"VOID":581},"W4292184386",{"EN":583},"\u003Cjats:p>Despite major therapeutic advances, heart failure, as a non-communicable disease, remains a life-threatening disorder, with 26 million patients worldwide, causing more deaths than cancer. Therefore, novel strategies for the treatment of heart failure continue to be an important clinical need. Based on preclinical studies, allogenic human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) patches have been proposed as a potential therapeutic candidate for heart failure. We report the implantation of allogeneic hiPSC-CM patches in a patient with ischemic cardiomyopathy (\u003Cjats:ext-link>ClinicalTrials.gov\u003C\u002Fjats:ext-link>, #jRCT2053190081). The patches were produced under clinical-grade conditions and displayed cardiogenic phenotypes and safety \u003Cjats:italic>in vivo\u003C\u002Fjats:italic> (severe immunodeficient mice) without any genetic mutations in cancer-related genes. The patches were then implanted via thoracotomy into the left ventricle epicardium of the patient under immunosuppressive agents. Positron emission tomography and computed tomography confirmed the potential efficacy and did not detect tumorigenesis in either the heart or other organs. The clinical symptoms improved 6 months after surgery, without any major adverse events, suggesting that the patches were well-tolerated. Furthermore, changes in the wall motion in the transplanted site were recovered, suggesting a favorable prognosis and the potential tolerance to exercise. This study is the first report of a successful transplant of hiPSC-CMs for severe ischemic cardiomyopathy.\u003C\u002Fjats:p>",{"EN":585},"Case report: Transplantation of human induced pluripotent stem cell-derived cardiomyocyte patches for ischemic cardiomyopathy",{"VOID":587},"36051285",{"VOID":589},"10.3389\u002Ffcvm.2022.950829","2025-02-01T21:55:49.979+00:00",[112],"https:\u002F\u002Fwww.frontiersin.org\u002Farticles\u002F10.3389\u002Ffcvm.2022.950829\u002Ffull",[594,614,630,653,676,691,708,725,742,760,776,797,815,831,848,865,882],{"id":595,"sortIndex":45,"researcher":23,"roles":596,"affiliations":597,"properties":609},"d5dfe123-a419-4b2c-bc7f-4555895c8694",[],[598],{"id":599,"sortIndex":24,"affiliation":600,"properties":23},"b62d029f-4d78-44e2-bf64-f56bb1798648",{"id":601,"createTime":602,"updateTime":603,"relativeEntities":604,"slug":605,"properties":606,"entityType":44,"verifyStatus":22,"verifyTime":23,"verifyNote":23,"syncStatus":22,"languages":23,"translateLanguages":23,"viewCount":24},"17a04bc8-6932-4eb4-b7ee-cd160955193f","2023-12-28T14:48:39.429+00:00","2025-02-01T21:55:49.999+00:00",[],"Department-of-Cardiovascular-Surgery-Osaka-University-Graduate-School-of-Medicine-Suita-Japan",{"title":607},{"VI":608},"Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Japan",{"openalex":610,"title":612},{"VOID":611},"A5058195347",{"EN":613},"Hiroko Iseoka",{"id":615,"sortIndex":616,"researcher":23,"roles":617,"affiliations":618,"properties":625},"0ed107e3-c4c6-4847-8eee-8ccd76a25c1e",6,[],[619],{"id":620,"sortIndex":24,"affiliation":621,"properties":23},"ea99edd0-4cf8-4f6c-8b99-c7247f7459e1",{"id":601,"createTime":602,"updateTime":603,"relativeEntities":622,"slug":605,"properties":623,"entityType":44,"verifyStatus":22,"verifyTime":23,"verifyNote":23,"syncStatus":22,"languages":23,"translateLanguages":23,"viewCount":24},[],{"title":624},{"VI":608},{"openalex":626,"title":628},{"VOID":627},"A5111530181",{"EN":629},"Emiko 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Patients with diabetes have chronic, low-level systemic inflammation, which results in global cellular dysfunction underlying the wide variety of symptoms associated with the disease, including an increased risk of respiratory infection. While the increased severity of COVID-19 amongst patients with diabetes is not yet fully understood, the common features associated with both diseases are dysregulated immune and inflammatory responses. An additional key player in COVID-19 is the enzyme, angiotensin-converting enzyme 2 (ACE2), which is essential for adhesion and uptake of virus into cells prior to replication. Changes to the expression of ACE2 in diabetes have been documented, but they vary across different organs and the importance of such changes on COVID-19 severity are still under investigation. 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10.1152\u002Fjappl.1989.66.1.421",{"doi":4257},"10.1152\u002Fjappl.1989.66.1.421",{"id":23,"text":4259,"url":23,"identifiers":4260},"Bowles, 1998, Exercise training increases K+-channel contribution to regulation of coronary arterial tone, J Appl Physiol., 84, 1225, 10.1152\u002Fjappl.1998.84.4.1225",{"doi":4261},"10.1152\u002Fjappl.1998.84.4.1225",{"id":23,"text":4263,"url":23,"identifiers":4264},"Laughlin, 2001, Training induces nonuniform increases in eNOS content along the coronary arterial tree, J Appl Physiol., 90, 501, 10.1152\u002Fjappl.2001.90.2.501",{"doi":4265},"10.1152\u002Fjappl.2001.90.2.501",{"id":23,"text":4267,"url":23,"identifiers":4268},"Durand, 2015, Acute exertion elicits a H2O2-dependent vasodilator mechanism in the microvasculature of exercise-trained but not sedentary adults, Hypertension, 65, 140, 10.1161\u002FHYPERTENSIONAHA.114.04540",{"doi":4269},"10.1161\u002FHYPERTENSIONAHA.114.04540",{"id":23,"text":4271,"url":23,"identifiers":4272},"Robinson, 2016, Improved arterial flow-mediated dilation after exertion involves hydrogen peroxide in overweight and obese adults following aerobic exercise training, J Hypertens., 34, 1309, 10.1097\u002FHJH.0000000000000946",{"doi":4273},"10.1097\u002FHJH.0000000000000946",{"id":23,"text":4275,"url":23,"identifiers":4276},"Simpson, 2003, Walking trends among U.S. adults: the Behavioral Risk Factor Surveillance System, 1987-2000, Am J Prev Med., 25, 95, 10.1016\u002FS0749-3797(03)00112-0",{"doi":4277},"10.1016\u002FS0749-3797(03)00112-0",{"id":23,"text":4279,"url":23,"identifiers":4280},"Wen, 2011, Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study, Lancet, 378, 1244, 10.1016\u002FS0140-6736(11)60749-6",{"doi":4281},"10.1016\u002FS0140-6736(11)60749-6",{"id":23,"text":4283,"url":23,"identifiers":4284},"O'Keefe, 2012, Potential adverse cardiovascular effects from excessive endurance exercise, Mayo Clin Proc., 87, 587, 10.1016\u002Fj.mayocp.2012.04.005",{"doi":4285},"10.1016\u002Fj.mayocp.2012.04.005",{"id":23,"text":4287,"url":23,"identifiers":4288},"Roberts, 2017, Fifty men, 3510 marathons, cardiac risk factors, and coronary artery calcium scores, Med Sci Sports Exerc., 49, 2369, 10.1249\u002FMSS.0000000000001373",{"doi":4289},"10.1249\u002FMSS.0000000000001373",{"id":23,"text":4291,"url":23,"identifiers":4292},"Laddu, 2017, 25-Year physical activity trajectories and development of subclinical coronary artery disease as measured by coronary artery calcium: the Coronary Artery Risk Development in Young Adults (CARDIA) study, Mayo Clin Proc., 92, 1660, 10.1016\u002Fj.mayocp.2017.07.016",{"doi":4293},"10.1016\u002Fj.mayocp.2017.07.016",{"id":23,"text":4295,"url":23,"identifiers":4296},"Aengevaeren, 2017, Relationship between lifelong exercise volume and coronary atherosclerosis in athletes, Circulation, 136, 138, 10.1161\u002FCIRCULATIONAHA.117.027834",{"doi":4297},"10.1161\u002FCIRCULATIONAHA.117.027834",{"id":23,"text":4299,"url":23,"identifiers":4300},"Merghani, 2017, Prevalence of subclinical coronary artery disease in masters endurance athletes with a low atherosclerotic risk profile, Circulation, 136, 126, 10.1161\u002FCIRCULATIONAHA.116.026964",{"doi":4301},"10.1161\u002FCIRCULATIONAHA.116.026964",{"id":23,"text":4303,"url":23,"identifiers":4304},"Howden, 2018, Reversing the cardiac effects of sedentary aging in middle age-a randomized controlled trial: implications for heart failure prevention, Circulation, 137, 1549, 10.1161\u002FCIRCULATIONAHA.117.030617",{"doi":4305},"10.1161\u002FCIRCULATIONAHA.117.030617",{"id":23,"text":4307,"url":23,"identifiers":4308},"Mora, 2007, Physical activity and reduced risk of cardiovascular events: potential mediating mechanisms, Circulation, 116, 2110, 10.1161\u002FCIRCULATIONAHA.107.729939",{"doi":4309},"10.1161\u002FCIRCULATIONAHA.107.729939",{"id":23,"text":4311,"url":23,"identifiers":4312},"Fernandez, 2018, Physical activity, immune system, and the microbiome in cardiovascular disease, Front Physiol., 9, 763, 10.3389\u002Ffphys.2018.00763",{"doi":4313},"10.3389\u002Ffphys.2018.00763",{"id":23,"text":4315,"url":23,"identifiers":4316},"Fiuza-Luces, 2018, Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors, Nat Rev Cardiol., 10.1038\u002Fs41569-018-0065-1",{"doi":4317},"10.1038\u002Fs41569-018-0065-1",{"id":23,"text":4319,"url":23,"identifiers":4320},"Boldyrev, 2013, Physiology and pathophysiology of carnosine, Physiol Rev., 93, 1803, 10.1152\u002Fphysrev.00039.2012",{"doi":4321},"10.1152\u002Fphysrev.00039.2012",{"id":4323,"createTime":4324,"updateTime":4324,"relativeEntities":4325,"slug":4326,"properties":4327,"entityType":108,"verifyStatus":109,"verifyTime":4341,"verifyNote":110,"syncStatus":22,"languages":4342,"translateLanguages":23,"viewCount":24,"primaryUrl":4343,"fullTextUrl":23,"authors":4344,"publicationType":226,"publisherRelationship":4650,"citationCount":632,"citationInfo":4678,"publishDate":23,"publishYear":23,"citationAnalyzeStatus":22,"lastCitationAnalyze":23,"indexDatabases":23,"openAccess":23,"references":4680,"isForceReanalyzing":572},"3963f9e2-dd2b-4626-ae91-196ea553ee7e","2025-01-01T08:57:54.820+00:00",[],"Prognostic-Significance-of-Feature-Tracking-Right-Ventricular-Global-Longitudinal-Strain-in-Non-ischemic-Dilated-Cardiomyopathy",{"mag":4328,"keywords":4330,"openalex":4331,"abstract":4333,"title":4335,"pm":4337,"doi":4339},{"VOID":4329},"3217421590",{},{"VOID":4332},"W3217421590",{"EN":4334},"\u003Cjats:p>\u003Cjats:bold>Aims:\u003C\u002Fjats:bold> Left ventricular global longitudinal strain (GLS) by cardiac magnetic resonance feature tracking (CMR-FT) analysis has shown an incremental prognostic value compared to classical parameters in non-ischemic dilated cardiomyopathy (NICM). However, less is known about the role of right ventricular (RV) GLS. Our objective was to evaluate the prognostic impact of RV-GLS by CMR-FT analysis in a population of NICM patients.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Methods:\u003C\u002Fjats:bold> In this multicenter study, we examined NICM patients evaluated with a comprehensive CMR-FT study. Major cardiac events (MACEs) were considered as the study primary outcome measure and were defined as a composite of (a) cardiovascular death, (b) cardiac transplant or destination therapy ventricular assist device, (c) hospitalization for life-threatening ventricular arrhythmias or implantable cardiac defibrillator appropriate intervention. Heart failure (HF) related events, including hospitalizations and life-threatening arrhythmia-related events were considered as secondary end-points. Receiver operating time-dependent analysis were used to calculate the possible additional effect of RV-GLS to standard evaluation.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Results:\u003C\u002Fjats:bold> We consecutively enrolled 273 patients. During a median follow-up of 39 months, 41 patients (15%) experienced MACEs. RV-GLS and LV late gadolinium emerged as the strongest prognostic CMR-FT variables: their association provided an estimated 3-year MACEs rate of 29%. The addition of RV-GLS significantly improved the prognostic accuracy in predicting MACEs with respect to the standard evaluation including LGE (areas under the curve from 0.71 [0.66–0.82] to 0.76 [0.66–0.86], \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.03). On competing risk analysis, RV-GLS showed a significant ability to reclassify overall both HF-related and life-threatening arrhythmia-related events, regardless of LV and RV ejection fraction.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Conclusions:\u003C\u002Fjats:bold> In NICM patients, RV-GLS showed a significant prognostic role in reclassifying the risk of MACEs, incremental with respect to standard evaluation with standard prognostic parameters.\u003C\u002Fjats:p>",{"EN":4336},"Prognostic Significance of Feature-Tracking Right Ventricular Global Longitudinal Strain in Non-ischemic Dilated 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2018, Evolving concepts in dilated cardiomyopathy, Eur J Heart Fail., 20, 228, 10.1002\u002Fejhf.1103",{"doi":4684},"10.1002\u002Fejhf.1103",{"id":23,"text":4686,"url":23,"identifiers":4687},"Gulati, 2013, The prevalence and prognostic significance of right ventricular systolic dysfunction in nonischemic dilated cardiomyopathy, Circulation., 128, 1623, 10.1161\u002FCIRCULATIONAHA.113.002518",{"doi":4688},"10.1161\u002FCIRCULATIONAHA.113.002518",{"id":23,"text":4690,"url":23,"identifiers":4691},"Di Marco, 2017, Late gadolinium enhancement and the risk for ventricular arrhythmias or sudden death in dilated cardiomyopathy: systematic review and meta-analysis, JACC: Heart Fail., 5, 28, 10.1016\u002Fj.jchf.2016.09.017",{"doi":4692},"10.1016\u002Fj.jchf.2016.09.017",{"id":23,"text":4694,"url":23,"identifiers":4695},"Perazzolo Marra, 2014, Impact of the presence and amount of myocardial fibrosis by cardiac magnetic resonance on arrhythmic outcome and sudden cardiac death in nonischemic dilated cardiomyopathy, Heart Rhythm., 11, 856, 10.1016\u002Fj.hrthm.2014.01.014",{"doi":4696},"10.1016\u002Fj.hrthm.2014.01.014",{"id":23,"text":4698,"url":23,"identifiers":4699},"Buss, 2015, Assessment of myocardial deformation with Cardiac magnetic resonance strain imaging improves risk stratification in patients with dilated cardiomyopathy, Eur Heart J Cardiovasc Imaging., 16, 307, 10.1093\u002Fehjci\u002Fjeu181",{"doi":4700},"10.1093\u002Fehjci\u002Fjeu181",{"id":23,"text":4702,"url":23,"identifiers":4703},"Romano, 2018, Feature-tracking global longitudinal strain predicts death in a multicenter population of patients with ischemic and nonischemic dilated cardiomyopathy incremental to ejection fraction and late gadolinium enhancement, JACC Cardiovasc Imaging., 10, 1419, 10.1016\u002Fj.jcmg.2017.10.024",{"doi":4704},"10.1016\u002Fj.jcmg.2017.10.024",{"id":23,"text":4706,"url":23,"identifiers":4707},"Liu, 2020, Association between right ventricular strain and outcomes in patients with dilated cardiomyopathy, Heart., 107, 1233, 10.1136\u002Fheartjnl-2020-317949",{"doi":4708},"10.1136\u002Fheartjnl-2020-317949",{"id":23,"text":4710,"url":23,"identifiers":4711},"Mason, 2007, Recommendations for the standardization and interpretation of the electrocardiogram: part II: electrocardiography diagnostic statement list a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society Endorsed by the International Society for Computerized Electrocardiology, J Am Coll Cardiol., 49, 1128, 10.1161\u002FCIRCULATIONAHA.106.180201",{"doi":4712},"10.1161\u002FCIRCULATIONAHA.106.180201",{"id":23,"text":4714,"url":23,"identifiers":4715},"Pinto, 2016, Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases, Eur Heart J., 37, 1850, 10.1093\u002Feurheartj\u002Fehv727",{"doi":4716},"10.1093\u002Feurheartj\u002Fehv727",{"id":23,"text":4718,"url":23,"identifiers":4719},"Lazarević, 2000, Early changes in left ventricular function in chronic asymptomatic alcoholics: relation to the duration of heavy drinking, JACC., 35, 1599, 10.1016\u002FS0735-1097(00)00565-9",{"doi":4720},"10.1016\u002FS0735-1097(00)00565-9",{"id":23,"text":4722,"url":23,"identifiers":4723},"Yancy, 2017, 2017 ACC\u002FAHA\u002FHFSA Focused Update of the 2013 ACCF\u002FAHA Guideline for the Management of Heart Failure: a Report of the American College of Cardiology\u002FAmerican Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America, Circulation., 136, e137, 10.1161\u002FCIR.0000000000000509",{"doi":4724},"10.1161\u002FCIR.0000000000000509",{"id":23,"text":4726,"url":23,"identifiers":4727},"Rickham, 1964, Human Experimentation. Code of Ethics of the World Medical Association Declaration of Helsinki, Br Med J, 2, 177, 10.1136\u002Fbmj.2.5402.177",{"doi":4728},"10.1136\u002Fbmj.2.5402.177",{"id":23,"text":4730,"url":23,"identifiers":4731},"Schulz-Menger, 2013, Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) board of trustees task force on standardized post processing, J Cardiovasc Magn Reson., 15, 35, 10.1186\u002F1532-429X-15-35",{"doi":4732},"10.1186\u002F1532-429X-15-35",{"id":23,"text":4734,"url":23,"identifiers":4735},"Almehmadi, 2014, Prevalence of myocardial fibrosis patterns in patients with systolic dysfunction: prognostic significance for the prediction of sudden cardiac arrest or appropriate implantable cardiac defibrillator therapy, Circ Cardiovasc Imaging., 7, 593, 10.1161\u002FCIRCIMAGING.113.001768",{"doi":4736},"10.1161\u002FCIRCIMAGING.113.001768",{"id":23,"text":4738,"url":23,"identifiers":4739},"Spezzacatene, 2015, Arrhythmogenic phenotype in dilated cardiomyopathy: natural history and predictors of life-threatening arrhythmias, J Am Heart Ass., 4, 1, 10.1161\u002FJAHA.115.002149",{"doi":4740},"10.1161\u002FJAHA.115.002149",{"id":23,"text":4742,"url":23,"identifiers":4743},"Gray, 1998, A class of K-sample tests for comparing the cumulative incidence of a competing risk, Ann Stat., 16, 1141, 10.1214\u002Faos\u002F1176350951",{"doi":4744},"10.1214\u002Faos\u002F1176350951",{"id":23,"text":4746,"url":23,"identifiers":4747},"Goeman, 2010, L1 penalized estimation in the Cox proportional hazards model, Biom J., 52, 70, 10.1002\u002Fbimj.200900028",{"doi":4748},"10.1002\u002Fbimj.200900028",{"id":23,"text":4750,"url":23,"identifiers":4751},"Grambsch, 1994, Proportional hazards tests and diagnostics based on weighted residuals, Biometrica., 81, 515, 10.1093\u002Fbiomet\u002F81.3.515",{"doi":4752},"10.1093\u002Fbiomet\u002F81.3.515",{"id":23,"text":4754,"url":23,"identifiers":4755},"Blanche, 2013, Estimating and comparing time-dependent areas under receiver operating characteristic curves for censored event times with competing risks, Stat Med., 32, 5381, 10.1002\u002Fsim.5958",{"doi":4756},"10.1002\u002Fsim.5958",{"id":23,"text":4758,"url":23,"identifiers":4759},"Walter, 1998, Sample size and optimal designs for reliability studies, Stat Med., 17, 101, 10.1002\u002F(SICI)1097-0258(19980115)17:1\u003C101::AID-SIM727>3.0.CO;2-E",{"doi":4760},"10.1002\u002F(SICI)1097-0258(19980115)17:1\u003C101::AID-SIM727>3.0.CO;2-E",{"id":23,"text":4762,"url":23,"identifiers":4763},"Merlo, 2016, The prognostic impact of the evolution of RV function in idiopathic DCM, J Am Coll Cardiol Img., 9, 1034, 10.1016\u002Fj.jcmg.2016.01.027",{"doi":4764},"10.1016\u002Fj.jcmg.2016.01.027",{"id":23,"text":4766,"url":23,"identifiers":4767},"Houard, 2019, Additional prognostic value of 2D right ventricular speckle-tracking strain for prediction of survival in heart failure and reduced ejection fraction. a comparative study with cardiac magnetic resonance, JACC Cardiovasc Imaging., 12, 2373, 10.1016\u002Fj.jcmg.2018.11.028",{"doi":4768},"10.1016\u002Fj.jcmg.2018.11.028",{"id":23,"text":4770,"url":23,"identifiers":4771},"Seo, 2019, The prognostic value of 2D strain in assessment of the right ventricle in patients with dilated cardiomyopathy, Eur Heart J Cardiovasc Imaging., 20, 1043, 10.1093\u002Fehjci\u002Fjez015",{"doi":4772},"10.1093\u002Fehjci\u002Fjez015",{"id":23,"text":4774,"url":23,"identifiers":4775},"Vîjîiac, 2021, The prognostic value of right ventricular longitudinal strain and 3D ejection fraction in patients with dilated cardiomyopathy, Int J Cardiovasc Imaging., 24, 1, 10.1007\u002Fs10554-021-02322-z",{"doi":4776},"10.1007\u002Fs10554-021-02322-z",{"id":23,"text":4778,"url":23,"identifiers":4779},"Antoni, 2010, Prognostic value of right ventricular function in patients after acute myocardial infarction treated with primary percutaneous coronary intervention, Circ Cardiovasc Imaging., 3, 264, 10.1161\u002FCIRCIMAGING.109.914366",{"doi":4780},"10.1161\u002FCIRCIMAGING.109.914366",{"id":23,"text":4782,"url":23,"identifiers":4783},"Sanz, 2019, Anatomy, function, and dysfunction of the right ventricle, JACC State Art Rev., 73, 1463, 10.1016\u002Fj.jacc.2018.12.076",{"doi":4784},"10.1016\u002Fj.jacc.2018.12.076",{"id":23,"text":4786,"url":23,"identifiers":4787},"Naeije, , The overloaded right heart and ventricular Interdependence, Cardiovasc Res., 1474",{},{"id":23,"text":4789,"url":23,"identifiers":4790},"Cavigli, 2020, The right ventricle in “Left-sided” cardiomyopathies: the dark side of the moon, Trends Cardiovasc Med., 13, S1050, 10.1016\u002Fj.tcm.2020.10.003",{"doi":4791},"10.1016\u002Fj.tcm.2020.10.003",{"id":23,"text":4793,"url":23,"identifiers":4794},"Bourfiss, 2017, Feature tracking CMR reveals abnormal strain in preclinical arrhythmogenic right ventricular dysplasia\u002Fcardiomyopathy: a multisoftware feasibility and clinical implementation study, J Cardiovasc Magn Reson., 19, 66, 10.1186\u002Fs12968-017-0380-4",{"doi":4795},"10.1186\u002Fs12968-017-0380-4",{"id":23,"text":4797,"url":23,"identifiers":4798},"Focardi, 2015, Traditional and innovative echocardiographic parameters for the analysis of right ventricular performance in comparison with cardiac magnetic resonance, Eur Heart J Cardiovasc Imaging., 16, 47, 10.1093\u002Fehjci\u002Fjeu156",{"doi":4799},"10.1093\u002Fehjci\u002Fjeu156",{"id":23,"text":4801,"url":23,"identifiers":4802},"Romano, 2017, Association of feature-tracking cardiac magnetic resonance imaging left ventricular global longitudinal strain with all cause mortality in patients with reduced left ventricular ejection fraction, Circulation., 135, 2313, 10.1161\u002FCIRCULATIONAHA.117.027740",{"doi":4803},"10.1161\u002FCIRCULATIONAHA.117.027740",{"id":23,"text":4805,"url":23,"identifiers":4806},"Stolfo, 2018, Arrhythmic risk stratification in patients with idiopathic dilated cardiomyopathy, Am J Cardiol., 121, 1601, 10.1016\u002Fj.amjcard.2018.02.055",{"doi":4807},"10.1016\u002Fj.amjcard.2018.02.055",{"id":23,"text":4809,"url":23,"identifiers":4810},"Gulati, 2013, Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy, JAMA, 309, 896, 10.1001\u002Fjama.2013.1363",{"doi":4811},"10.1001\u002Fjama.2013.1363",{"id":23,"text":4813,"url":23,"identifiers":4814},"Gigli, 2019, Genetic risk of arrhythmic phenotypes in patients with dilated cardiomyopathy, J Am Coll Cardiol., 74, 1480, 10.1016\u002Fj.jacc.2019.06.072",{"doi":4815},"10.1016\u002Fj.jacc.2019.06.072",{"id":23,"text":4817,"url":23,"identifiers":4818},"Køber, 2016, Defibrillator implantation in patients with nonischemic systolic heart failure, N Eng J Med., 375, 1221, 10.1056\u002FNEJMoa1608029",{"doi":4819},"10.1056\u002FNEJMoa1608029",{"id":4821,"createTime":4822,"updateTime":4822,"relativeEntities":4823,"slug":4824,"properties":4825,"entityType":108,"verifyStatus":109,"verifyTime":4822,"verifyNote":110,"syncStatus":22,"languages":4839,"translateLanguages":23,"viewCount":24,"primaryUrl":4840,"fullTextUrl":23,"authors":4841,"publicationType":226,"publisherRelationship":5029,"citationCount":158,"citationInfo":5057,"publishDate":23,"publishYear":23,"citationAnalyzeStatus":22,"lastCitationAnalyze":23,"indexDatabases":23,"openAccess":23,"references":5059,"isForceReanalyzing":572},"c3ded766-abc2-4a49-861d-31036aaa6dbf","2024-10-05T08:02:53.306+00:00",[],"Heart-Failure-Probability-and-Early-Outcomes-of-Critically-Ill-Patients-With-COVID-19-A-Prospective-Multicenter-Study",{"mag":4826,"keywords":4828,"openalex":4829,"abstract":4831,"title":4833,"pm":4835,"doi":4837},{"VOID":4827},"3217129130",{},{"VOID":4830},"W3217129130",{"EN":4832},"\u003Cjats:p>\u003Cjats:bold>Background:\u003C\u002Fjats:bold> The relationship between cardiac functions and the fatal outcome of coronavirus disease 2019 (COVID-19) is still largely underestimated. We aim to explore the role of heart failure (HF) and NT-proBNP in the prognosis of critically ill patients with COVID-19 and construct an easy-to-use predictive model using machine learning.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Methods:\u003C\u002Fjats:bold> In this multicenter and prospective study, a total of 1,050 patients with clinical suspicion of COVID-19 were consecutively screened. Finally, 402 laboratory-confirmed critically ill patients with COVID-19 were enrolled. A “triple cut-point” strategy of NT-proBNP was applied to assess the probability of HF. The primary outcome was 30-day all-cause in-hospital death. Prognostic risk factors were analyzed using the least absolute shrinkage and selection operator (LASSO) and multivariate logistic regression, further formulating a nomogram to predict mortality.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Results:\u003C\u002Fjats:bold> Within a 30-day follow-up, 27.4% of the 402 patients died. The mortality rate of patients with HF likely was significantly higher than that of the patient with gray zone and HF unlikely (40.8% vs. 25 and 16.5%, respectively, \u003Cjats:italic>P\u003C\u002Fjats:italic> < 0.001). HF likely [Odds ratio (OR) 1.97, 95% CI 1.13–3.42], age (OR 1.04, 95% CI 1.02–1.06), lymphocyte (OR 0.36, 95% CI 0.19–0.68), albumin (OR 0.92, 95% CI 0.87–0.96), and total bilirubin (OR 1.02, 95% CI 1–1.04) were independently associated with the prognosis of critically ill patients with COVID-19. Moreover, a nomogram was developed by bootstrap validation, and C-index was 0.8 (95% CI 0.74–0.86).\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Conclusions:\u003C\u002Fjats:bold> This study established a novel nomogram to predict the 30-day all-cause mortality of critically ill patients with COVID-19, highlighting the predominant role of the “triple cut-point” strategy of NT-proBNP, which could assist in risk stratification and improve clinical sequelae.\u003C\u002Fjats:p>",{"EN":4834},"Heart Failure Probability and Early Outcomes of Critically Ill Patients With COVID-19: A Prospective, Multicenter 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