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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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Acceptance decisions are based on the originality and quality of the research and its prospective interest to a wide readership. Papers submitted to The FEBS Journal should provide novel perspectives on a biologically relevant problem and be of interest to a broad readership. The scope of the Journal is broad and inclusive. We are particularly interested in papers in which state-of-the-art approaches are applied to bring novel insight into molecular and cellular mechanisms that underlie the functions of molecules, cells and organisms. The Journal also welcomes manuscripts of an interdisciplinary nature, including systems approaches that address fundamental concepts in molecular, cellular or organismal biology. The Journal does not accept papers that lack biological insight. Papers describing bioinformatic analysis, modelling or structural studies of specific systems or molecules should include experimental data. 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In addition, the Journal publishes Special Issues that provide detailed insight into a specific scientific field.","PENDING",[886,892,898],{"id":887,"createTime":28,"updateTime":28,"relativeEntities":888,"label":889,"description":891,"parentId":28,"standard":28,"scholarHubFieldId":28},"131e254e-0b02-478f-aa3e-0b27d8c7b9d1",[],{"EN":890},"Cell Biology",{},{"id":893,"createTime":28,"updateTime":28,"relativeEntities":894,"label":895,"description":897,"parentId":28,"standard":28,"scholarHubFieldId":28},"e28d6c37-225c-41f9-829b-a62e54bf45c7",[],{"EN":896},"Molecular Biology",{},{"id":899,"createTime":28,"updateTime":28,"relativeEntities":900,"label":901,"description":903,"parentId":28,"standard":28,"scholarHubFieldId":28},"73d2c682-bae9-48e0-a003-8e0ed8c9715d",[],{"EN":902},"Biochemistry",{},[905,912],{"id":906,"createTime":28,"updateTime":28,"relativeEntities":907,"slug":28,"properties":908,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":911,"statistic":28},"05e99a76-c414-4c8f-ae6d-56ed57566774",[],{"title":909},{"EN":910},"Wiley-Blackwell Publishing Ltd",[],{"id":913,"createTime":28,"updateTime":28,"relativeEntities":914,"slug":28,"properties":915,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":918,"statistic":28},"43d4a537-d044-4372-8544-ca45c3bea38f",[],{"title":916},{"EN":917},"WILEY",[],[920,936],{"id":921,"indexDatabase":922,"url":933,"indexYears":28,"academicFieldIds":934,"indexDatabaseRanking":28},"ae9214da-ff57-4e6b-ba11-609818fa06f6",{"id":923,"createTime":28,"updateTime":28,"relativeEntities":924,"label":925,"description":927,"key":930,"publicationTags":931,"standard":28},"a4921856-b128-4d9f-8f1f-e80813d3bbd4",[],{"EN":926,"VI":926},"ISI\u002FSCIE - Science Citation Index Expanded",{"EN":928,"VI":929},"SCIE database","Cơ sở dữ liệu SCIE","scie",[932,813],"SCIE","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=1742-464X",[935],"10e9c71e-2256-419c-bdd2-a39e436e76e3",{"id":937,"indexDatabase":938,"url":943,"indexYears":944,"academicFieldIds":945,"indexDatabaseRanking":949},"3365ec39-8ed9-4e2e-a675-f65f830fc387",{"id":775,"createTime":28,"updateTime":28,"relativeEntities":939,"label":940,"description":941,"key":781,"publicationTags":942,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],"https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F38597","2005-2025",[946,947,948],"0404956d-7818-4510-b67a-db80799a6ec0","578ed71b-dd6b-46c6-8851-2657dbd3629e","d2139bd1-2fdb-481b-a416-9c30dd0cc173","SCOPUS__Q1","https:\u002F\u002Ffebs.onlinelibrary.wiley.com\u002Fjournal\u002F17424658",{"meta":952,"data":954},{"total":953},"970",[955,1187,1335,1474,1661,1873,2042,2254,2641,2931],{"id":956,"createTime":957,"updateTime":958,"relativeEntities":959,"slug":960,"properties":961,"entityType":978,"verifyStatus":26,"verifyTime":957,"verifyNote":979,"languages":980,"translateLanguages":981,"viewCount":32,"primaryUrl":982,"fullTextUrl":28,"authors":983,"publicationType":1018,"publisherRelationship":1019,"citationCount":1073,"citationInfo":1074,"publishDate":1089,"publishYear":1075,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":1090,"openAccess":28,"references":1091,"isForceReanalyzing":1186},"4f67c502-d770-4400-b531-d8d1fe6efa91","2024-09-12T23:59:45.257+00:00","2025-02-14T02:57:03.547+00:00",[],"Involvement-of-the-Superoxide-Anion-Radical-in-the-Autoxidation-of-Pyrogallol-and-a-Convenient-Assay-for-Superoxide-Dismutase",{"mag":962,"keywords":964,"openalex":966,"abstract":968,"title":971,"pm":974,"doi":976},{"VOID":963},"2088866343",{"VI":965},"pyrogallol, autoxidation, superoxide dismutase, anion superoxide, catalase",{"VOID":967},"W2088866343",{"EN":969,"VI":970},"\u003Cjats:p>The autoxidation of pyrogallol was investigated in the presence of EDTA in the pH range 7.9–10.6.\u003C\u002Fjats:p>\u003Cjats:p>The rate of autoxidation increases with increasing pH. At pH 7.9 the reaction is inhibited to 99% by superoxide dismutase, indicating an almost total dependence on the participation of the superoxide anion radical, O\u003Cjats:sub>2\u003C\u002Fjats:sub>·\u003Cjats:sup>−\u003C\u002Fjats:sup>, in the reaction. Up to pH 9.1 the reaction is still inhibited to over 90% by superoxide dismutase, but at higher alkalinity, O\u003Cjats:sub>2\u003C\u002Fjats:sub>·\u003Cjats:sup>−\u003C\u002Fjats:sup> ‐independent mechanisms rapidly become dominant.\u003C\u002Fjats:p>\u003Cjats:p>Catalase has no effect on the autoxidation but decreases the oxygen consumption by half, showing that H\u003Cjats:sub>2\u003C\u002Fjats:sub>O\u003Cjats:sub>2\u003C\u002Fjats:sub> is the stable product of oxygen and that H\u003Cjats:sub>2\u003C\u002Fjats:sub>O\u003Cjats:sub>2\u003C\u002Fjats:sub> is not involved in the autoxidation mechanism.\u003C\u002Fjats:p>\u003Cjats:p>A simple and rapid method for the assay of superoxide dismutase is described, based on the ability of the enzyme to inhibit the autoxidation of pyrogallol.\u003C\u002Fjats:p>\u003Cjats:p>A plausible explanation is given for the non‐competitive part of the inhibition of catechol \u003Cjats:italic>O\u003C\u002Fjats:italic>‐methyltransferase brought about by pyrogallol.\u003C\u002Fjats:p>","\u003Cjats:p>Quá trình tự oxi hóa của pyrogallol đã được khảo sát trong sự hiện diện của EDTA trong khoảng pH từ 7,9 đến 10,6.\u003C\u002Fjats:p>\u003Cjats:p>Tốc độ tự oxi hóa tăng khi pH tăng. Tại pH 7,9, phản ứng bị ức chế tới 99% bởi superoxide dismutase, cho thấy sự phụ thuộc gần như hoàn toàn vào sự tham gia của gốc anion superoxide, O\u003Cjats:sub>2\u003C\u002Fjats:sub>·\u003Cjats:sup>−\u003C\u002Fjats:sup>, trong phản ứng. Cho đến pH 9,1, phản ứng vẫn bị ức chế trên 90% bởi superoxide dismutase, nhưng tại tính kiềm cao hơn, các cơ chế không phụ thuộc vào O\u003Cjats:sub>2\u003C\u002Fjats:sub>·\u003Cjats:sup>−\u003C\u002Fjats:sup> nhanh chóng trở nên chi phối.\u003C\u002Fjats:p>\u003Cjats:p>Catalase không có ảnh hưởng đến quá trình tự oxi hóa nhưng làm giảm tiêu thụ oxy đến một nửa, cho thấy rằng H\u003Cjats:sub>2\u003C\u002Fjats:sub>O\u003Cjats:sub>2\u003C\u002Fjats:sub> là sản phẩm ổn định của oxy và rằng H\u003Cjats:sub>2\u003C\u002Fjats:sub>O\u003Cjats:sub>2\u003C\u002Fjats:sub> không tham gia vào cơ chế tự oxi hóa.\u003C\u002Fjats:p>\u003Cjats:p>Một phương pháp đơn giản và nhanh chóng để xác định superoxide dismutase được mô tả, dựa trên khả năng của enzyme để ức chế quá trình tự oxi hóa của pyrogallol.\u003C\u002Fjats:p>\u003Cjats:p>Một lời giải thích hợp lý được đưa ra cho phần ức chế không cạnh tranh của catechol \u003Cjats:italic>O\u003C\u002Fjats:italic>-methyltransferase do pyrogallol gây ra.\u003C\u002Fjats:p>",{"EN":972,"VI":973},"Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase","Vai trò của gốc anion superoxide trong quá trình tự oxi hóa của pyrogallol và một phương pháp thử nghiệm thuận lợi cho superoxide dismutase",{"VOID":975},"4215654",{"VOID":977},"10.1111\u002Fj.1432-1033.1974.tb03714.x","PUBLICATION","Auto Verify",[31],[30],"https:\u002F\u002Ffebs.onlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1432-1033.1974.tb03714.x",[984,1003],{"id":985,"sortIndex":32,"researcher":28,"roles":986,"affiliations":987,"properties":996},"8ce75d37-1c0d-443a-abb2-6bd6e0d6fd89",[],[988],{"id":989,"sortIndex":32,"affiliation":990,"properties":28},"2014b8f7-6903-4623-b87e-60fc6d047d10",{"id":989,"createTime":28,"updateTime":28,"relativeEntities":991,"slug":28,"properties":992,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":995,"statistic":28},[],{"title":993},{"EN":994},"Kemiska Institutionen, Avdelningen för Medicinsk Kemi, Umeå Universitet, S-901 87 Umeå, Sweden",[],{"orcid":997,"title":999,"openalex":1001},{"VOID":998},"https:\u002F\u002Forcid.org\u002F0000-0002-3270-2854",{"EN":1000},"Stefan L. Marklund",{"VOID":1002},"A5031486216",{"id":1004,"sortIndex":40,"researcher":28,"roles":1005,"affiliations":1006,"properties":1013},"c47a8125-a137-4816-a068-d92fffc92b5b",[],[1007],{"id":989,"sortIndex":32,"affiliation":1008,"properties":28},{"id":989,"createTime":28,"updateTime":28,"relativeEntities":1009,"slug":28,"properties":1010,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1012,"statistic":28},[],{"title":1011},{"EN":994},[],{"title":1014,"openalex":1016},{"EN":1015},"Gudrun MARKLUND",{"VOID":1017},"A5089178503","ARTICLE",{"url":28,"publisher":1020,"properties":1066},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1021,"slug":872,"properties":1022,"entityType":25,"verifyStatus":884,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1027,"manageAffiliations":1040,"indexDatabases":1051,"url":950,"thumbnailPath":28,"statistic":28,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"country":1023,"eissn":1024,"issn":1025,"title":1026},{"VOID":875},{"VOID":877},{"VOID":879},{"EN":881},[1028,1032,1036],{"id":887,"createTime":28,"updateTime":28,"relativeEntities":1029,"label":1030,"description":1031,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},{"id":893,"createTime":28,"updateTime":28,"relativeEntities":1033,"label":1034,"description":1035,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":896},{},{"id":899,"createTime":28,"updateTime":28,"relativeEntities":1037,"label":1038,"description":1039,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":902},{},[1041,1046],{"id":906,"createTime":28,"updateTime":28,"relativeEntities":1042,"slug":28,"properties":1043,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1045,"statistic":28},[],{"title":1044},{"EN":910},[],{"id":913,"createTime":28,"updateTime":28,"relativeEntities":1047,"slug":28,"properties":1048,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1050,"statistic":28},[],{"title":1049},{"EN":917},[],[1052,1059],{"id":921,"indexDatabase":1053,"url":933,"indexYears":28,"academicFieldIds":1058,"indexDatabaseRanking":28},{"id":923,"createTime":28,"updateTime":28,"relativeEntities":1054,"label":1055,"description":1056,"key":930,"publicationTags":1057,"standard":28},[],{"EN":926,"VI":926},{"EN":928,"VI":929},[932,813],[935],{"id":937,"indexDatabase":1060,"url":943,"indexYears":944,"academicFieldIds":1065,"indexDatabaseRanking":949},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":1061,"label":1062,"description":1063,"key":781,"publicationTags":1064,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[946,947,948],{"issue":1067,"pages":1069,"volume":1071},{"VOID":1068},"3",{"VOID":1070},"469-474",{"VOID":1072},"47",9410,{"total":1073,"publishYear":1075,"statisticByYear":1076},1974,{"2012":1077,"2013":1078,"2014":1079,"2015":1080,"2016":1081,"2017":1082,"2018":1083,"2019":1084,"2020":1085,"2021":1086,"2022":1087,"2023":1088,"2024":276},450,448,580,478,490,459,502,477,510,582,598,539,"1974-09-01",[932],[1092,1095,1098,1102,1105,1108,1111,1114,1117,1120,1123,1126,1130,1134,1137,1140,1143,1146,1149,1152,1155,1158,1161,1164,1167,1170,1173,1176,1179,1182],{"id":28,"text":1093,"url":28,"identifiers":1094},"Taube H., 1965, Oxygen, 29",{},{"id":28,"text":1096,"url":28,"identifiers":1097},"10.1016\u002FS0021-9258(18)63504-5",{"doi":1096},{"id":28,"text":1099,"url":28,"identifiers":1100},"Mc Cord J. M., 1969, J. Biol. Chem., 244, 6056, 10.1016\u002FS0021-9258(18)63505-7",{"doi":1101},"10.1016\u002FS0021-9258(18)63505-7",{"id":28,"text":1103,"url":28,"identifiers":1104},"10.1016\u002FS0021-9258(19)45228-9",{"doi":1103},{"id":28,"text":1106,"url":28,"identifiers":1107},"10.1126\u002Fscience.181.4098.456",{"doi":1106},{"id":28,"text":1109,"url":28,"identifiers":1110},"10.1016\u002FS0021-9258(19)44987-9",{"doi":1109},{"id":28,"text":1112,"url":28,"identifiers":1113},"10.1016\u002F0005-2744(72)90359-2",{"doi":1112},{"id":28,"text":1115,"url":28,"identifiers":1116},"10.1016\u002F0005-2795(71)90077-8",{"doi":1115},{"id":28,"text":1118,"url":28,"identifiers":1119},"10.1016\u002FS0021-9258(18)48655-3",{"doi":1118},{"id":28,"text":1121,"url":28,"identifiers":1122},"Kortüm G., 1961, Dissociation Constants of Organic Acids in Aqueous Solution, 443",{},{"id":28,"text":1124,"url":28,"identifiers":1125},"10.1002\u002Fcber.19130460398",{"doi":1124},{"id":28,"text":1127,"url":28,"identifiers":1128},"Barltrop J. A.&Nicholson J. S.(1948)J. Chem. Soc.116–120.",{"doi":1129},"10.1039\u002Fjr9480000116",{"id":28,"text":1131,"url":28,"identifiers":1132},"Miyahara S., 1971, J. Biochem. (Tokyo), 69, 231, 10.1093\u002Foxfordjournals.jbchem.a129450",{"doi":1133},"10.1093\u002Foxfordjournals.jbchem.a129450",{"id":28,"text":1135,"url":28,"identifiers":1136},"10.1038\u002F1811153a0",{"doi":1135},{"id":28,"text":1138,"url":28,"identifiers":1139},"10.1042\u002Fbj1350379",{"doi":1138},{"id":28,"text":1141,"url":28,"identifiers":1142},"10.1016\u002FS0021-9258(19)43969-0",{"doi":1141},{"id":28,"text":1144,"url":28,"identifiers":1145},"10.1016\u002F0003-9861(74)90320-8",{"doi":1144},{"id":28,"text":1147,"url":28,"identifiers":1148},"10.3891\u002Facta.chem.scand.27-1458",{"doi":1147},{"id":28,"text":1150,"url":28,"identifiers":1151},"Ghosh J. C., 1937, Biochem. Z., 294, 330",{},{"id":28,"text":1153,"url":28,"identifiers":1154},"10.1016\u002F0014-5793(72)80132-7",{"doi":1153},{"id":28,"text":1156,"url":28,"identifiers":1157},"10.1016\u002F0014-5793(72)80632-X",{"doi":1156},{"id":28,"text":1159,"url":28,"identifiers":1160},"Paschen W., 1973, Biochim. Biophys. Acta, 327, 211",{},{"id":28,"text":1162,"url":28,"identifiers":1163},"10.1126\u002Fscience.168.3930.476",{"doi":1162},{"id":28,"text":1165,"url":28,"identifiers":1166},"10.1111\u002Fj.1751-1097.1972.tb06241.x",{"doi":1165},{"id":28,"text":1168,"url":28,"identifiers":1169},"10.1111\u002Fj.1751-1097.1973.tb06449.x",{"doi":1168},{"id":28,"text":1171,"url":28,"identifiers":1172},"10.1021\u002Fja00776a003",{"doi":1171},{"id":28,"text":1174,"url":28,"identifiers":1175},"10.1016\u002F0006-2952(61)90067-3",{"doi":1174},{"id":28,"text":1177,"url":28,"identifiers":1178},"10.1016\u002F0006-2952(73)90277-3",{"doi":1177},{"id":28,"text":1180,"url":28,"identifiers":1181},"10.1098\u002Frspa.1934.0221",{"doi":1180},{"id":28,"text":1183,"url":28,"identifiers":1184},"Axelrod J., 1958, J. Biol. Chem., 233, 702, 10.1016\u002FS0021-9258(18)64731-3",{"doi":1185},"10.1016\u002FS0021-9258(18)64731-3",false,{"id":1188,"createTime":1189,"updateTime":1190,"relativeEntities":1191,"slug":1192,"properties":1193,"entityType":978,"verifyStatus":26,"verifyTime":1189,"verifyNote":979,"languages":1210,"translateLanguages":1211,"viewCount":32,"primaryUrl":1212,"fullTextUrl":28,"authors":1213,"publicationType":1018,"publisherRelationship":1254,"citationCount":1308,"citationInfo":1309,"publishDate":1311,"publishYear":1075,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":1312,"openAccess":28,"references":1313,"isForceReanalyzing":1186},"3268bd03-379b-49a5-9598-603032a62808","2024-07-19T00:16:13.723+00:00","2025-02-14T02:57:59.636+00:00",[],"A-Film-Detection-Method-for-Tritium-Labelled-Proteins-and-Nucleic-Acids-in-Polyacrylamide-Gels",{"mag":1194,"keywords":1196,"openalex":1198,"abstract":1200,"title":1203,"pm":1206,"doi":1208},{"VOID":1195},"2034277598",{"VI":1197},"phát hiện tritium, gel polyacrylamide, phương pháp tự phát quang, protein gắn tritium, axit nucleic gắn tritium",{"VOID":1199},"W2034277598",{"EN":1201,"VI":1202},"\u003Cjats:p>A simple method is described for detecting \u003Cjats:sup>3\u003C\u002Fjats:sup>H in polyacrylamide gels by scintillation autography (fluorography) using X‐ray film. The gel is dehydrated in dimethyl sulphoxide, soaked in a solution of 2,5‐diphenyloxazole (PPO) in dimethylsulphoxide, dried and exposed to RP Royal “X‐Omat” film at ‐70 °C. Optimal conditions for each step are described. β‐particles from \u003Cjats:sup>3\u003C\u002Fjats:sup>H interact with the 2,5‐diphenyloxazole emitting light which causes local blackening of an X‐ray film. The image produced resembles that obtained by conventional autoradiography of isotopes with higher emission energies such as \u003Cjats:sup>14\u003C\u002Fjats:sup>C. 3000 dis. \u003Cjats:sup>3\u003C\u002Fjats:sup>H\u002Fmin in a band in a gel can be detected in a 24‐h exposure. Similarly 500 dis.\u002Fmin can be detected in one week.\u003C\u002Fjats:p>\u003Cjats:p>When applied to the detection of \u003Cjats:sup>35\u003C\u002Fjats:sup>S and \u003Cjats:sup>14\u003C\u002Fjats:sup>C in polyacrylamide gels, this method is ten times more sensitive than conventional autoradiography. 130 dis. \u003Cjats:sup>35\u003C\u002Fjats:sup>S or \u003Cjats:sup>14\u003C\u002Fjats:sup>C\u002Fmin in a band in a gel can be detected in 24 h.\u003C\u002Fjats:p>","\u003Cjats:p>Trong nghiên cứu này, một phương pháp đơn giản để phát hiện \u003Cjats:sup>3\u003C\u002Fjats:sup>H trong gel polyacrylamide bằng kỹ thuật tự phát quang (scintillation autography) sử dụng phim X-quang được mô tả. Gel được khử nước trong dimethyl sulfoxide, ngâm trong dung dịch 2,5-diphenyloxazole (PPO) trong dimethyl sulfoxide, sau đó được làm khô và tiếp xúc với phim RP Royal “X-Omat” ở nhiệt độ -70 °C. Các điều kiện tối ưu cho từng bước được mô tả chi tiết. Các hạt β từ \u003Cjats:sup>3\u003C\u002Fjats:sup>H tương tác với 2,5-diphenyloxazole phát ra ánh sáng, dẫn đến việc làm đen cục bộ trên phim X-quang. Hình ảnh được tạo ra tương tự như hình ảnh thu được từ autoradiography cổ điển của các đồng vị có năng lượng phát ra cao hơn như \u003Cjats:sup>14\u003C\u002Fjats:sup>C. Có thể phát hiện được 3000 dis. \u003Cjats:sup>3\u003C\u002Fjats:sup>H\u002Fphút trong một dải trong gel trong thời gian phơi sáng 24 giờ. Tương tự, 500 dis.\u002Fphút cũng có thể được phát hiện trong một tuần.\u003C\u002Fjats:p>\u003Cjats:p>Khi áp dụng để phát hiện \u003Cjats:sup>35\u003C\u002Fjats:sup>S và \u003Cjats:sup>14\u003C\u002Fjats:sup>C trong gel polyacrylamide, phương pháp này nhạy hơn gấp mười lần so với autoradiography thông thường. Có thể phát hiện 130 dis. \u003Cjats:sup>35\u003C\u002Fjats:sup>S hoặc \u003Cjats:sup>14\u003C\u002Fjats:sup>C\u002Fphút trong một dải trong gel trong thời gian 24 giờ.\u003C\u002Fjats:p>",{"EN":1204,"VI":1205},"A Film Detection Method for Tritium‐Labelled Proteins and Nucleic Acids in Polyacrylamide Gels","Phương Pháp Phát Hiện Bằng Phim Đối Với Các Protein và Axit Nucleic Gắn Tritium Trong Gel Polyacrylamide",{"VOID":1207},"4850204",{"VOID":1209},"10.1111\u002Fj.1432-1033.1974.tb03599.x",[31],[30],"https:\u002F\u002Ffebs.onlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1432-1033.1974.tb03599.x",[1214,1239],{"id":1215,"sortIndex":32,"researcher":28,"roles":1216,"affiliations":1217,"properties":1234},"3fa70bba-2abf-486b-bb48-47243d3b017f",[],[1218,1226],{"id":1219,"sortIndex":32,"affiliation":1220,"properties":28},"ff381b45-579a-4bbe-9557-6b5dfb1806b0",{"id":1219,"createTime":28,"updateTime":28,"relativeEntities":1221,"slug":28,"properties":1222,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1225,"statistic":28},[],{"title":1223},{"EN":1224},"Department of Health, Education and Welfare, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, U.S.A. 20014",[],{"id":1227,"sortIndex":40,"affiliation":1228,"properties":28},"31d4d673-877e-43f6-b77a-5d6bbbf777aa",{"id":1227,"createTime":28,"updateTime":28,"relativeEntities":1229,"slug":28,"properties":1230,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1233,"statistic":28},[],{"title":1231},{"EN":1232},"M. R. C. Laboratory of Molecular Biology, Postgraduate Medical School, University of Cambridge, Hills Road, Cambridge, Great Britain CB2 2QH",[],{"title":1235,"openalex":1237},{"EN":1236},"William M. Bonner",{"VOID":1238},"A5060968786",{"id":1240,"sortIndex":40,"researcher":28,"roles":1241,"affiliations":1242,"properties":1249},"08262039-f706-4262-8e77-2d0912f885ab",[],[1243],{"id":1227,"sortIndex":32,"affiliation":1244,"properties":28},{"id":1227,"createTime":28,"updateTime":28,"relativeEntities":1245,"slug":28,"properties":1246,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1248,"statistic":28},[],{"title":1247},{"EN":1232},[],{"title":1250,"openalex":1252},{"EN":1251},"Ronald A. 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T., 1958, Nature (Lond.), 182, 524, 10.1038\u002F182524a0",{"doi":1315},{"id":28,"text":1448,"url":28,"identifiers":1449},"Luthi U., 1965, Nature (Lond.), 205, 1190, 10.1038\u002F2051190a0",{"doi":1450},"10.1038\u002F2051190a0",{"id":28,"text":1452,"url":28,"identifiers":1453},"Contractor S.F., 1969, J. Chromatogr., 41, 483, 10.1016\u002F0021-9673(64)80172-2",{"doi":1454},"10.1016\u002F0021-9673(64)80172-2",{"id":28,"text":1318,"url":28,"identifiers":1456},{"doi":1318},{"id":28,"text":1458,"url":28,"identifiers":1459},"Shine J., 1974, Anal. Biochem., 59, 360, 10.1016\u002F0003-2697(74)90287-5",{"doi":1460},"10.1016\u002F0003-2697(74)90287-5",{"id":28,"text":1462,"url":28,"identifiers":1463},"Bonner W. M., 1974, Eur. J. Biochem., 46, 83, 10.1111\u002Fj.1432-1033.1974.tb03599.x",{"doi":1209},{"id":28,"text":1465,"url":28,"identifiers":1466},"Gurdon J. B., 1971, Nature (Lond.), 233, 177, 10.1038\u002F233177a0",{"doi":1467},"10.1038\u002F233177a0",{"id":28,"text":1469,"url":28,"identifiers":1470},"Laskey R. A., 1972, Proc. Natl Acad. Sci. U.S.A., 69, 3665, 10.1073\u002Fpnas.69.12.3665",{"doi":1324},{"id":28,"text":1472,"url":28,"identifiers":1473},"Mees C. E. K., 1966, The Theory of the Photographic Process, 3",{},{"id":1475,"createTime":1476,"updateTime":1477,"relativeEntities":1478,"slug":1479,"properties":1480,"entityType":978,"verifyStatus":26,"verifyTime":1476,"verifyNote":979,"languages":1497,"translateLanguages":1498,"viewCount":32,"primaryUrl":1499,"fullTextUrl":28,"authors":1500,"publicationType":1018,"publisherRelationship":1537,"citationCount":1590,"citationInfo":1591,"publishDate":1594,"publishYear":1592,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":1595,"openAccess":28,"references":1596,"isForceReanalyzing":1186},"c4427dd1-1501-449e-9eeb-17a517533719","2024-09-13T05:14:57.594+00:00","2025-02-14T02:58:55.646+00:00",[],"An-Efficient-mRNA-Dependent-Translation-System-from-Reticulocyte-Lysates",{"mag":1481,"keywords":1483,"openalex":1485,"abstract":1487,"title":1490,"pm":1493,"doi":1495},{"VOID":1482},"1970403529",{"VI":1484},"",{"VOID":1486},"W1970403529",{"EN":1488,"VI":1489},"\u003Cjats:p>A simple method is described for converting a standard rabbit reticulocyte cell‐free extract (lysate) into an mRNA‐dependent protein synthesis system. The lysate is preincubated with CaCl\u003Cjats:sub>2\u003C\u002Fjats:sub> and micrococcal nuclease, and then excess ethyleneglycol‐bis(2‐aminoethylether)‐N,N′‐tetraacetic acid is added to chelate the Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup> and inactivate the nuclease. Lysates treated in this way have negligible endogenous amino acid incorporation activity, but 75% of the activity of the original lysate can be recovered by the addition of globin mRNA. The efficiency utilisation of added mRNA and the sensitivity of the system are both very high. No residual nuclease activity could be detected, and the tRNA is functionally unimpaired. Several different species of mRNA have been shown to be translated efficiently into full‐sized products of the expected molecular weight up to about 200 000, and there is no detectable accumulation of incomplete protein products. The efficient translation of RNA from two plant viruses (tobacco mosaic virus and cowpea mosaic virus) required heterologous tRNA.\u003C\u002Fjats:p>","\u003Cjats:p>Trong bài báo này, một phương pháp đơn giản được mô tả để chuyển đổi dịch chiết không tế bào (lysate) từ tế bào reticulocyte của thỏ thành một hệ thống tổng hợp protein phụ thuộc vào mRNA. Dịch lysate được tiền ấp với CaCl\u003Cjats:sub>2\u003C\u002Fjats:sub> và nuclease micrococcal, sau đó thêm một lượng lớn ethyleneglycol-bis(2-aminoethylether)-N,N′-tetraacetic acid để chelat hóa Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup> và làm bất hoạt nuclease. Các lysate được xử lý theo cách này có hoạt tính gắn amino acid nội sinh không đáng kể, nhưng 75% hoạt tính của lysate ban đầu có thể được phục hồi bằng cách thêm mRNA globin. Hiệu suất sử dụng mRNA bổ sung và độ nhạy của hệ thống đều rất cao. Không thể phát hiện hoạt tính nuclease còn lại, và tRNA vẫn hoạt động bình thường. Một số loại mRNA khác nhau đã được chứng minh là được dịch mã một cách hiệu quả thành các sản phẩm có kích thước đầy đủ với khối lượng phân tử như mong đợi lên đến khoảng 200 000, và không có sự tích tụ các sản phẩm protein chưa hoàn thiện. Việc dịch mã hiệu quả RNA từ hai loại virus thực vật (virus mosaic thuốc lá và virus mosaic đậu) yêu cầu tRNA dị hợp.\u003C\u002Fjats:p>",{"EN":1491,"VI":1492},"An Efficient mRNA‐Dependent Translation System from Reticulocyte Lysates","Một Hệ Thống Dịch MRNA Phụ Thuộc Hiệu Quả Từ Các Dịch Chuyển Tế Bào Reticulocyte",{"VOID":1494},"823012",{"VOID":1496},"10.1111\u002Fj.1432-1033.1976.tb10656.x",[31],[30],"https:\u002F\u002Ffebs.onlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1432-1033.1976.tb10656.x",[1501,1520],{"id":1502,"sortIndex":32,"researcher":28,"roles":1503,"affiliations":1504,"properties":1513},"2b2d34cd-7bd7-44c2-ab9a-aeb3c1264179",[],[1505],{"id":1506,"sortIndex":32,"affiliation":1507,"properties":28},"d7b3d3f9-b43c-4bef-a481-3a3ad7962674",{"id":1506,"createTime":28,"updateTime":28,"relativeEntities":1508,"slug":28,"properties":1509,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1512,"statistic":28},[],{"title":1510},{"EN":1511},"Department of Biochemistry, University of Camdridge, Tennis Court Road, Cambridge, Great Britain, CB2 IQW",[],{"orcid":1514,"title":1516,"openalex":1518},{"VOID":1515},"https:\u002F\u002Forcid.org\u002F0000-0002-8137-0278",{"EN":1517},"Hugh R.B. Pelham",{"VOID":1519},"A5053567351",{"id":1521,"sortIndex":40,"researcher":28,"roles":1522,"affiliations":1523,"properties":1530},"a70d7dd3-854b-4316-94c7-4d750e8ccf21",[],[1524],{"id":1506,"sortIndex":32,"affiliation":1525,"properties":28},{"id":1506,"createTime":28,"updateTime":28,"relativeEntities":1526,"slug":28,"properties":1527,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1529,"statistic":28},[],{"title":1528},{"EN":1511},[],{"orcid":1531,"title":1533,"openalex":1535},{"VOID":1532},"https:\u002F\u002Forcid.org\u002F0000-0002-8840-9198",{"EN":1534},"Richard J. 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G., 1972, J. Biol. Chem., 43, 5357, 10.1016\u002FS0021-9258(20)81113-2",{"doi":1606},"10.1016\u002FS0021-9258(20)81113-2",{"id":28,"text":1608,"url":28,"identifiers":1609},"Krystosek A., 1974, J. Biol. Chem., 250, 6077, 10.1016\u002FS0021-9258(19)41161-7",{"doi":1610},"10.1016\u002FS0021-9258(19)41161-7",{"id":28,"text":1612,"url":28,"identifiers":1613},"10.1016\u002FS0021-9258(18)96126-0",{"doi":1612},{"id":28,"text":1615,"url":28,"identifiers":1616},"10.1016\u002F0022-2836(73)90511-1",{"doi":1615},{"id":28,"text":1618,"url":28,"identifiers":1619},"10.1073\u002Fpnas.70.8.2330",{"doi":1618},{"id":28,"text":1621,"url":28,"identifiers":1622},"10.1016\u002F0022-2836(73)90003-X",{"doi":1621},{"id":28,"text":1321,"url":28,"identifiers":1624},{"doi":1321},{"id":28,"text":1350,"url":28,"identifiers":1626},{"doi":1350},{"id":28,"text":1628,"url":28,"identifiers":1629},"10.1016\u002F0042-6822(74)90345-6",{"doi":1628},{"id":28,"text":1631,"url":28,"identifiers":1632},"10.1016\u002F0006-291X(74)90668-8",{"doi":1631},{"id":28,"text":1634,"url":28,"identifiers":1635},"10.1016\u002F0006-291X(75)90325-3",{"doi":1634},{"id":28,"text":1637,"url":28,"identifiers":1638},"10.1073\u002Fpnas.50.5.924",{"doi":1637},{"id":28,"text":1640,"url":28,"identifiers":1641},"10.1016\u002FS0042-6822(72)80004-7",{"doi":1640},{"id":28,"text":1643,"url":28,"identifiers":1644},"10.1111\u002Fj.1432-1033.1976.tb10029.x",{"doi":1643},{"id":28,"text":1646,"url":28,"identifiers":1647},"10.1016\u002F0042-6822(75)90278-0",{"doi":1646},{"id":28,"text":1649,"url":28,"identifiers":1650},"Lane G. D., 1971, J. Mol. Biol., 43, 73, 10.1016\u002F0022-2836(71)90207-5",{"doi":1651},"10.1016\u002F0022-2836(71)90207-5",{"id":28,"text":1653,"url":28,"identifiers":1654},"10.1038\u002Fnewbio241150a0",{"doi":1653},{"id":28,"text":1656,"url":28,"identifiers":1657},"10.1016\u002FS0021-9258(19)41914-5",{"doi":1656},{"id":28,"text":1659,"url":28,"identifiers":1660},"10.1016\u002F0005-2787(75)90168-9",{"doi":1659},{"id":1662,"createTime":1663,"updateTime":1664,"relativeEntities":1665,"slug":1666,"properties":1667,"entityType":978,"verifyStatus":26,"verifyTime":1663,"verifyNote":979,"languages":1683,"translateLanguages":1684,"viewCount":32,"primaryUrl":1685,"fullTextUrl":28,"authors":1686,"publicationType":1018,"publisherRelationship":1753,"citationCount":1807,"citationInfo":1808,"publishDate":1821,"publishYear":1809,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":1822,"openAccess":28,"references":1823,"isForceReanalyzing":1186},"83d958ea-2329-495c-a9d7-030d4e30d693","2024-11-28T10:20:10.588+00:00","2025-02-14T02:59:53.028+00:00",[],"Investigation-of-the-Alamar-Blue-resazurin-fluorescent-dye-for-the-assessment-of-mammalian-cell-cytotoxicity",{"mag":1668,"keywords":1670,"openalex":1671,"abstract":1673,"title":1676,"pm":1679,"doi":1681},{"VOID":1669},"2154385453",{"VI":1484},{"VOID":1672},"W2154385453",{"EN":1674,"VI":1675},"\u003Cjats:p>We show here the identity of Alamar Blue as resazurin. The ‘resazurin reduction test’ has been used for about 50 years to monitor bacterial and yeast contamination of milk, and also for assessing semen quality. Resazurin (blue and nonfluorescent) is reduced to resorufin (pink and highly fluorescent) which is further reduced to hydroresorufin (uncoloured and nonfluorescent). It is still not known how this reduction occurs, intracellularly via enzyme activity or in the medium as a chemical reaction, although the reduced fluorescent form of Alamar Blue was found in the cytoplasm and of living cells nucleus of dead cells. Recently, the dye has gained popularity as a very simple and versatile way of measuring cell proliferation and cytotoxicity. This dye presents numerous advantages over other cytotoxicity or proliferation tests but we observed several drawbacks to the routine use of Alamar Blue. Tests with several toxicants in different cell lines and rat primary hepatocytes have shown accumulation of the fluorescent product of Alamar Blue in the medium which could lead to an overestimation of cell population. Also, the extensive reduction of Alamar Blue by metabolically active cells led to a final nonfluorescent product, and hence an underestimation of cellular activity.\u003C\u002Fjats:p>","\u003Cjats:p>Chúng tôi đã chỉ ra rằng Alamar Blue chính là resazurin. ‘Thử nghiệm giảm resazurin’ đã được sử dụng trong khoảng 50 năm để theo dõi sự ô nhiễm vi khuẩn và nấm men trong sữa, cũng như để đánh giá chất lượng tinh trùng. Resazurin (màu xanh và không phát quang) được giảm thành resorufin (màu hồng và phát quang mạnh) và tiếp tục được giảm thành hydroresorufin (không màu và không phát quang). Vẫn chưa biết quá trình giảm này xảy ra như thế nào, bên trong tế bào thông qua hoạt động enzyme hay trong môi trường như một phản ứng hóa học, mặc dù dạng huỳnh quang đã được giảm của Alamar Blue đã được phát hiện trong tế bào chất và trong nhân của các tế bào sống và tế bào chết. Gần đây, thuốc nhuộm này đã trở nên phổ biến như một cách rất đơn giản và linh hoạt để đo lường sự phát triển của tế bào và tính độc tế bào. Thuốc nhuộm này có nhiều ưu điểm so với các thử nghiệm độc tế bào hay phát triển tế bào khác, nhưng chúng tôi đã quan sát thấy một số nhược điểm trong việc sử dụng Alamar Blue thường xuyên. Các thử nghiệm với một số chất độc hại trên các dòng tế bào khác nhau và tế bào gan sơ cấp của chuột đã cho thấy sự tích lũy sản phẩm huỳnh quang của Alamar Blue trong môi trường, điều này có thể dẫn đến việc ước lượng quá mức về dân số tế bào. Hơn nữa, việc giảm mạnh Alamar Blue bởi các tế bào có hoạt động trao đổi chất dẫn đến một sản phẩm cuối không phát quang, vì vậy có thể dẫn đến việc ước lượng thấp về hoạt động tế bào.\u003C\u002Fjats:p>",{"EN":1677,"VI":1678},"Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity","Nghiên cứu thuốc nhuộm huỳnh quang Alamar Blue (resazurin) để đánh giá tính độc tế bào của tế bào động vật có vú",{"VOID":1680},"10951200",{"VOID":1682},"10.1046\u002Fj.1432-1327.2000.01606.x",[31],[30],"https:\u002F\u002Ffebs.onlinelibrary.wiley.com\u002Fdoi\u002F10.1046\u002Fj.1432-1327.2000.01606.x",[1687,1706,1723,1738],{"id":1688,"sortIndex":32,"researcher":28,"roles":1689,"affiliations":1690,"properties":1699},"3c4783a2-b7e3-4a47-ab60-7d8cdf07a7d3",[],[1691],{"id":1692,"sortIndex":32,"affiliation":1693,"properties":28},"16a4aa7a-f7f9-400b-8739-c11f6e2f327d",{"id":1692,"createTime":28,"updateTime":28,"relativeEntities":1694,"slug":28,"properties":1695,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1698,"statistic":28},[],{"title":1696},{"VI":1697},"AstraZeneca, Alderley Park, Macclesfield, UK",[],{"orcid":1700,"title":1702,"openalex":1704},{"VOID":1701},"https:\u002F\u002Forcid.org\u002F0000-0002-0270-3442",{"EN":1703},"John O’Brien",{"VOID":1705},"A5064044258",{"id":1707,"sortIndex":40,"researcher":28,"roles":1708,"affiliations":1709,"properties":1716},"da473012-611d-43c6-a876-09b3ef2234d2",[],[1710],{"id":1692,"sortIndex":32,"affiliation":1711,"properties":28},{"id":1692,"createTime":28,"updateTime":28,"relativeEntities":1712,"slug":28,"properties":1713,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1715,"statistic":28},[],{"title":1714},{"VI":1697},[],{"orcid":1717,"title":1719,"openalex":1721},{"VOID":1718},"https:\u002F\u002Forcid.org\u002F0000-0002-8558-7394",{"EN":1720},"Ian D. 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Orton",{"VOID":1737},"A5111803716",{"id":1739,"sortIndex":42,"researcher":28,"roles":1740,"affiliations":1741,"properties":1748},"fecd58ee-1266-4eca-93a2-5ee971ac4d61",[],[1742],{"id":1692,"sortIndex":32,"affiliation":1743,"properties":28},{"id":1692,"createTime":28,"updateTime":28,"relativeEntities":1744,"slug":28,"properties":1745,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1747,"statistic":28},[],{"title":1746},{"VI":1697},[],{"title":1749,"openalex":1751},{"EN":1750},"François Pognan",{"VOID":1752},"A5055535343",{"url":28,"publisher":1754,"properties":1800},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1755,"slug":872,"properties":1756,"entityType":25,"verifyStatus":884,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1761,"manageAffiliations":1774,"indexDatabases":1785,"url":950,"thumbnailPath":28,"statistic":28,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"country":1757,"eissn":1758,"issn":1759,"title":1760},{"VOID":875},{"VOID":877},{"VOID":879},{"EN":881},[1762,1766,1770],{"id":887,"createTime":28,"updateTime":28,"relativeEntities":1763,"label":1764,"description":1765,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},{"id":893,"createTime":28,"updateTime":28,"relativeEntities":1767,"label":1768,"description":1769,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":896},{},{"id":899,"createTime":28,"updateTime":28,"relativeEntities":1771,"label":1772,"description":1773,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":902},{},[1775,1780],{"id":906,"createTime":28,"updateTime":28,"relativeEntities":1776,"slug":28,"properties":1777,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1779,"statistic":28},[],{"title":1778},{"EN":910},[],{"id":913,"createTime":28,"updateTime":28,"relativeEntities":1781,"slug":28,"properties":1782,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1784,"statistic":28},[],{"title":1783},{"EN":917},[],[1786,1793],{"id":921,"indexDatabase":1787,"url":933,"indexYears":28,"academicFieldIds":1792,"indexDatabaseRanking":28},{"id":923,"createTime":28,"updateTime":28,"relativeEntities":1788,"label":1789,"description":1790,"key":930,"publicationTags":1791,"standard":28},[],{"EN":926,"VI":926},{"EN":928,"VI":929},[932,813],[935],{"id":937,"indexDatabase":1794,"url":943,"indexYears":944,"academicFieldIds":1799,"indexDatabaseRanking":949},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":1795,"label":1796,"description":1797,"key":781,"publicationTags":1798,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[946,947,948],{"issue":1801,"pages":1803,"volume":1805},{"VOID":1802},"17",{"VOID":1804},"5421-5426",{"VOID":1806},"267",3153,{"total":1807,"publishYear":1809,"statisticByYear":1810},2000,{"2012":603,"2013":1811,"2014":1812,"2015":1813,"2016":216,"2017":1814,"2018":1815,"2019":1816,"2020":1817,"2021":1818,"2022":282,"2023":1819,"2024":1820},181,201,187,222,207,192,212,180,166,121,"2000-09-01",[932],[1824,1827,1830,1833,1836,1839,1842,1845,1848,1851,1854,1857,1860,1864,1867,1870],{"id":28,"text":1825,"url":28,"identifiers":1826},"Fields R.D., 1993, Dual‐attribute continuous monitoring of cell proliferation\u002Fcytotoxicity, Am. Biotechnol. Lab., 11, 48",{},{"id":28,"text":1828,"url":28,"identifiers":1829},"10.1002\u002Fjcla.1860090203",{"doi":1828},{"id":28,"text":1831,"url":28,"identifiers":1832},"10.3168\u002Fjds.S0022-0302(50)91981-3",{"doi":1831},{"id":28,"text":1834,"url":28,"identifiers":1835},"10.3109\u002F01485019808987928",{"doi":1834},{"id":28,"text":1837,"url":28,"identifiers":1838},"10.1007\u002Fs11626-998-0130-x",{"doi":1837},{"id":28,"text":1840,"url":28,"identifiers":1841},"Pagé B., 1993, A new fluorimetric assay for cytotoxicity measurements in vitro, Int. J. Oncol., 3, 473",{},{"id":28,"text":1843,"url":28,"identifiers":1844},"10.1016\u002Fs0022-1759(97)00043-4",{"doi":1843},{"id":28,"text":1846,"url":28,"identifiers":1847},"10.1016\u002F0022-1759(94)90396-4",{"doi":1846},{"id":28,"text":1849,"url":28,"identifiers":1850},"10.1016\u002Fs0165-0270(96)00118-5",{"doi":1849},{"id":28,"text":1852,"url":28,"identifiers":1853},"10.1016\u002FB978-0-12-461201-3.50026-8",{"doi":1852},{"id":28,"text":1855,"url":28,"identifiers":1856},"10.1093\u002Fcarcin\u002F18.5.1021",{"doi":1855},{"id":28,"text":1858,"url":28,"identifiers":1859},"10.1046\u002Fj.1365-2605.1998.00126.x",{"doi":1858},{"id":28,"text":1861,"url":28,"identifiers":1862},"Matsumoto K., 1990, Fluorometric determination of carnitine in serum with immobilized carnitine dehydrogenase and diaphorase, Clin. Chem., 36, 2072, 10.1093\u002Fclinchem\u002F36.12.2072",{"doi":1863},"10.1093\u002Fclinchem\u002F36.12.2072",{"id":28,"text":1865,"url":28,"identifiers":1866},"10.1007\u002FBF00689804",{"doi":1865},{"id":28,"text":1868,"url":28,"identifiers":1869},"10.1006\u002Fbbrc.1994.1165",{"doi":1868},{"id":28,"text":1871,"url":28,"identifiers":1872},"10.1016\u002F0009-8981(80)90442-8",{"doi":1871},{"id":1874,"createTime":1875,"updateTime":1876,"relativeEntities":1877,"slug":1878,"properties":1879,"entityType":978,"verifyStatus":26,"verifyTime":1875,"verifyNote":979,"languages":1895,"translateLanguages":1896,"viewCount":32,"primaryUrl":1897,"fullTextUrl":28,"authors":1898,"publicationType":1018,"publisherRelationship":1931,"citationCount":1983,"citationInfo":1984,"publishDate":1987,"publishYear":1985,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":1988,"openAccess":28,"references":1989,"isForceReanalyzing":1186},"20c2d3ef-58ac-4bbf-b403-03d062ba7722","2024-09-19T22:17:28.644+00:00","2025-02-14T03:00:50.075+00:00",[],"A-Protein-Sequenator",{"mag":1880,"keywords":1882,"openalex":1883,"abstract":1885,"title":1888,"pm":1891,"doi":1893},{"VOID":1881},"2085474307",{"VI":1484},{"VOID":1884},"W2085474307",{"EN":1886,"VI":1887},"\u003Cjats:p>The protein sequenator is an instrument for the automatic determination of amino acid sequences in proteins and peptides. It operates on the principle of the phenylisothiocyanate degradation scheme. The automated process embraces the formation of the phenylthiocarbamyl derivative of the protein and the splitting off of the N‐terminal amino acid as thiazolinone. The degradation proceeds at a rate of 15.4 cycles in 24 hours and with a yield in the individual cycle in excess of 98%. The material requirements are approximately 0.25 μmoles of protein. The thiazolinones are converted to the corresponding phenylthiohydantoins in a separate operation, and the latter identified by thin layer chromatography. The process has been applied to the whole molecule of apomyoglobin from the humpback whale, and it has been possible to establish the sequence of the first 60 amino acids from the N‐terminal end.\u003C\u002Fjats:p>","\u003Cjats:p>Máy xác định chuỗi protein là một thiết bị dùng để xác định tự động các chuỗi axit amin trong protein và peptide. Thiết bị hoạt động dựa trên nguyên tắc của sơ đồ phân hủy phenylisothiocyanate. Quy trình tự động bao gồm việc hình thành dẫn xuất phenylthiocarbamyl của protein và việc cắt tách axit amin N‐terminal dưới dạng thiazolinone. Quá trình phân hủy diễn ra với tốc độ 15.4 chu kỳ trong 24 giờ và với tỷ lệ thu được trong từng chu kỳ vượt quá 98%. Các yêu cầu về vật liệu khoảng 0.25 μmol protein. Các thiazolinone được chuyển đổi thành phenylthiohydantoins tương ứng trong một quy trình riêng biệt, và các dẫn xuất này được xác định bằng phương pháp sắc ký lớp mỏng. Quy trình đã được áp dụng cho phân tử toàn bộ của apomyoglobin từ cá kình, và có thể xác định được chuỗi của 60 axit amin đầu tiên từ đầu N‐terminal.\u003C\u002Fjats:p>",{"EN":1889,"VI":1890},"A Protein Sequenator","Máy xác định chuỗi protein",{"VOID":1892},"6059350",{"VOID":1894},"10.1111\u002Fj.1432-1033.1967.tb00047.x",[31],[30],"https:\u002F\u002Ffebs.onlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1432-1033.1967.tb00047.x",[1899,1916],{"id":1900,"sortIndex":32,"researcher":28,"roles":1901,"affiliations":1902,"properties":1911},"5dc97561-b720-4533-aed6-cf52d93771a4",[],[1903],{"id":1904,"sortIndex":32,"affiliation":1905,"properties":28},"2f96af71-36d4-4a96-aed7-f9dde4700e0b",{"id":1904,"createTime":28,"updateTime":28,"relativeEntities":1906,"slug":28,"properties":1907,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1910,"statistic":28},[],{"title":1908},{"EN":1909},"St. Vincent's School of Medical Research Melbourne, N. 6, Victoria, Australia",[],{"title":1912,"openalex":1914},{"EN":1913},"Pehr Edman",{"VOID":1915},"A5075628987",{"id":1917,"sortIndex":40,"researcher":28,"roles":1918,"affiliations":1919,"properties":1926},"f5068b24-3919-4c0a-ac42-5850eb18820e",[],[1920],{"id":1904,"sortIndex":32,"affiliation":1921,"properties":28},{"id":1904,"createTime":28,"updateTime":28,"relativeEntities":1922,"slug":28,"properties":1923,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1925,"statistic":28},[],{"title":1924},{"EN":1909},[],{"title":1927,"openalex":1929},{"EN":1928},"Geoffrey S. Begg",{"VOID":1930},"A5078372616",{"url":28,"publisher":1932,"properties":1978},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1933,"slug":872,"properties":1934,"entityType":25,"verifyStatus":884,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1939,"manageAffiliations":1952,"indexDatabases":1963,"url":950,"thumbnailPath":28,"statistic":28,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"country":1935,"eissn":1936,"issn":1937,"title":1938},{"VOID":875},{"VOID":877},{"VOID":879},{"EN":881},[1940,1944,1948],{"id":887,"createTime":28,"updateTime":28,"relativeEntities":1941,"label":1942,"description":1943,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},{"id":893,"createTime":28,"updateTime":28,"relativeEntities":1945,"label":1946,"description":1947,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":896},{},{"id":899,"createTime":28,"updateTime":28,"relativeEntities":1949,"label":1950,"description":1951,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":902},{},[1953,1958],{"id":906,"createTime":28,"updateTime":28,"relativeEntities":1954,"slug":28,"properties":1955,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1957,"statistic":28},[],{"title":1956},{"EN":910},[],{"id":913,"createTime":28,"updateTime":28,"relativeEntities":1959,"slug":28,"properties":1960,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1962,"statistic":28},[],{"title":1961},{"EN":917},[],[1964,1971],{"id":921,"indexDatabase":1965,"url":933,"indexYears":28,"academicFieldIds":1970,"indexDatabaseRanking":28},{"id":923,"createTime":28,"updateTime":28,"relativeEntities":1966,"label":1967,"description":1968,"key":930,"publicationTags":1969,"standard":28},[],{"EN":926,"VI":926},{"EN":928,"VI":929},[932,813],[935],{"id":937,"indexDatabase":1972,"url":943,"indexYears":944,"academicFieldIds":1977,"indexDatabaseRanking":949},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":1973,"label":1974,"description":1975,"key":781,"publicationTags":1976,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[946,947,948],{"issue":1979,"pages":1980,"volume":1982},{"VOID":1303},{"VOID":1981},"80-91",{"VOID":1303},2824,{"total":1983,"publishYear":1985,"statisticByYear":1986},1967,{"2012":135,"2013":135,"2014":131,"2015":135,"2016":147,"2017":130,"2018":133,"2019":122,"2020":146,"2021":135,"2022":323,"2023":323,"2024":45},"1967-03-01",[932],[1990,1993,1996,1999,2002,2006,2009,2012,2015,2018,2021,2024,2027,2030,2033,2036,2039],{"id":28,"text":1991,"url":28,"identifiers":1992},"10.3891\u002Facta.chem.scand.10-0761",{"doi":1991},{"id":28,"text":1994,"url":28,"identifiers":1995},"Bethell D., 1965, Chem. Comm., 10, 189",{},{"id":28,"text":1997,"url":28,"identifiers":1998},"10.1071\u002FCH9630411",{"doi":1997},{"id":28,"text":2000,"url":28,"identifiers":2001},"Edman P., 1963, Thromb. et Diath. Haemorrhag., 17",{},{"id":28,"text":2003,"url":28,"identifiers":2004},"Fischer A., 1954, Z. Naturforsch., 9, 508, 10.1515\u002Fzna-1954-0604",{"doi":2005},"10.1515\u002Fzna-1954-0604",{"id":28,"text":2007,"url":28,"identifiers":2008},"10.1016\u002F0304-4165(66)90437-5",{"doi":2007},{"id":28,"text":2010,"url":28,"identifiers":2011},"10.1039\u002Fjr9560000188",{"doi":2010},{"id":28,"text":2013,"url":28,"identifiers":2014},"Edman P., 1957, Proc. Roy. Australian Chem. Inst., 434",{},{"id":28,"text":2016,"url":28,"identifiers":2017},"Teremoto S., 1954, Hakko Kogaku Zasshi, 32, 350",{},{"id":28,"text":2019,"url":28,"identifiers":2020},"10.1098\u002Frspa.1957.0002",{"doi":2019},{"id":28,"text":2022,"url":28,"identifiers":2023},"10.3891\u002Facta.chem.scand.13-1542",{"doi":2022},{"id":28,"text":2025,"url":28,"identifiers":2026},"Theorell H., 1954, Ann. Acad. Sci. Fennicae Ser. A II, 60, 303",{},{"id":28,"text":2028,"url":28,"identifiers":2029},"10.3891\u002Facta.chem.scand.10-1507",{"doi":2028},{"id":28,"text":2031,"url":28,"identifiers":2032},"10.1002\u002Fhlca.19610440123",{"doi":2031},{"id":28,"text":2034,"url":28,"identifiers":2035},"10.1038\u002F205883a0",{"doi":2034},{"id":28,"text":2037,"url":28,"identifiers":2038},"10.1021\u002Fjo01094a627",{"doi":2037},{"id":28,"text":2040,"url":28,"identifiers":2041},"10.1021\u002Fbi00887a031",{"doi":2040},{"id":2043,"createTime":2044,"updateTime":2045,"relativeEntities":2046,"slug":2047,"properties":2048,"entityType":978,"verifyStatus":26,"verifyTime":2044,"verifyNote":979,"languages":2064,"translateLanguages":2065,"viewCount":32,"primaryUrl":2066,"fullTextUrl":28,"authors":2067,"publicationType":1018,"publisherRelationship":2102,"citationCount":2155,"citationInfo":2156,"publishDate":2159,"publishYear":2157,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":2160,"openAccess":28,"references":2161,"isForceReanalyzing":1186},"3a798345-596c-4fd5-bbe9-fdda6b92b0ea","2024-10-14T23:35:42.579+00:00","2025-02-14T03:01:50.625+00:00",[],"Purification-of-Mouse-Immunoglobulin-Heavy-Chain-Messenger-RNAs-from-Total-Myeloma-Tumor-RNA",{"mag":2049,"keywords":2051,"openalex":2052,"abstract":2054,"title":2057,"pm":2060,"doi":2062},{"VOID":2050},"1990205754",{"VI":1484},{"VOID":2053},"W1990205754",{"EN":2055,"VI":2056},"\u003Cjats:p>A procedure is described for the large‐scale purification of light (L) and heavy (H) chain mRNAs from plasmacytomas produced in mice. Intact RNA is selectively precipitated in high yield from frozen tumors homogenized in 3 M LiCl and 6 M urea. L and H‐chain mRNAs were purified by oligo(dT)‐cellulose chromatography and either sucrose gradient centrifugation in conditions preventing aggregation or by means of high‐resolution preparative gel electrophoresis under non‐denaturing conditions. γ2a and α H‐chain mRNAs sedimented as major components at 15.5 S and 16.5 S respectively, when L‐chain mRNAs sedimented as 12‐S species. H‐chain mRNAs isolated by continuous elution during preparative gel electrophoresis were completely separated from both L‐chain mRNA and residual 18‐S rRNA, and migrated as single components of 1900 ± 50 nucleotides on analytical denaturing gels. The partially purified H‐chain mRNAs were translated into major components of molecular weights of 56000 (γ2a) and 60000 (α) in an mRNA‐dependent rabbit reticulocyte lysate, whereas L‐chain mRNAs yielded polypeptides of molecular weights of 25000 (λ) and 27000 (к). Up to 95% of the translation products directed by the purified mRNAs were immunoprecipitated using specific antisera. The purity of L and H‐chain mRNAs was assessed by hybridization of corresponding cDNAs with excess recombinant plasmid DNA. The results indicated a minimum purity of 47% (γ2a), 62% (α), for H‐chain mRNAs and 60% (к), for L‐chain mRNAs.\u003C\u002Fjats:p>","\u003Cjats:p>Một quy trình được mô tả để tinh chế quy mô lớn RNA mRNA chuỗi nhẹ (L) và chuỗi nặng (H) từ các khối u plasmacytoma được sản xuất ở chuột. RNA nguyên vẹn được kết tủa chọn lọc với hiệu suất cao từ các khối u đông lạnh được đồng hóa trong 3 M LiCl và 6 M urê. RNA mRNA chuỗi L và H được tinh chế bằng sắc ký oligo(dT)-cellulose và hoặc bằng ly tâm gradient sucrose trong các điều kiện ngăn ngừa sự kết tụ hoặc bằng phương pháp điện di gel chuẩn bị phân giải cao trong điều kiện không biến tính. RNA mRNA γ2a và α chuỗi nặng lắng đọng như các thành phần chính ở 15,5 S và 16,5 S tương ứng, khi RNA mRNA chuỗi L lắng đọng ở dạng 12-S. RNA mRNA chuỗi H được tách ra bằng cách rửa liên tục trong quá trình điện di gel chuẩn bị hoàn toàn phân lập khỏi cả RNA mRNA chuỗi L và rRNA 18-S còn lại, và di chuyển như các thành phần đơn lẻ có kích thước 1900 ± 50 nucleotide trên các gel phân giải biệt hóa phân tích. Các RNA mRNA chuỗi H đã được tinh chế một phần được dịch mã thành các thành phần chính có trọng lượng phân tử 56000 (γ2a) và 60000 (α) trong lysate reticulocyte thỏ phụ thuộc vào mRNA, trong khi RNA mRNA chuỗi L tạo ra các polypeptide có trọng lượng phân tử 25000 (λ) và 27000 (к). Tối đa 95% các sản phẩm dịch mã do các mRNA tinh chế hướng dẫn đã được kết tủa miễn dịch bằng cách sử dụng huyết thanh kháng thể đặc hiệu. Độ tinh khiết của các RNA mRNA chuỗi L và H được đánh giá bằng cách lai cDNA tương ứng với DNA plasmid tái tổ hợp dư thừa. Các kết quả cho thấy độ tinh khiết tối thiểu là 47% (γ2a), 62% (α) đối với RNA mRNA chuỗi H và 60% (к) đối với RNA mRNA chuỗi L.\u003C\u002Fjats:p>",{"EN":2058,"VI":2059},"Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA","Tách chiết RNA thông tin chuỗi nặng của globulin miễn dịch từ RNA khối u đa gai ở chuột",{"VOID":2061},"6772444",{"VOID":2063},"10.1111\u002Fj.1432-1033.1980.tb06030.x",[31],[30],"https:\u002F\u002Ffebs.onlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1432-1033.1980.tb06030.x",[2068,2087],{"id":2069,"sortIndex":32,"researcher":28,"roles":2070,"affiliations":2071,"properties":2080},"aabe47d5-da86-4758-8767-21a8986a61de",[],[2072],{"id":2073,"sortIndex":32,"affiliation":2074,"properties":28},"2fb6b629-3b9b-4c0e-9188-de1d74b6dec0",{"id":2073,"createTime":28,"updateTime":28,"relativeEntities":2075,"slug":28,"properties":2076,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2079,"statistic":28},[],{"title":2077},{"EN":2078},"Groupe de Biologie Moléculaire du Gène, Equipe de Recherche Associée N° 201 du Centre National de la Recherche Scientifique, Unité de Génie Génétique, Institut Pasteur, 28 Rue du Docteur-Roux, F-75724 Paris-Cedex 15, France",[],{"orcid":2081,"title":2083,"openalex":2085},{"VOID":2082},"https:\u002F\u002Forcid.org\u002F0000-0003-2226-7411",{"EN":2084},"Charles Auffray",{"VOID":2086},"A5055008823",{"id":2088,"sortIndex":40,"researcher":28,"roles":2089,"affiliations":2090,"properties":2097},"d23069f8-2513-4c58-941e-4781843f0fcc",[],[2091],{"id":2073,"sortIndex":32,"affiliation":2092,"properties":28},{"id":2073,"createTime":28,"updateTime":28,"relativeEntities":2093,"slug":28,"properties":2094,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2096,"statistic":28},[],{"title":2095},{"EN":2078},[],{"title":2098,"openalex":2100},{"EN":2099},"François Rougeon",{"VOID":2101},"A5050874203",{"url":28,"publisher":2103,"properties":2149},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":2104,"slug":872,"properties":2105,"entityType":25,"verifyStatus":884,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":2110,"manageAffiliations":2123,"indexDatabases":2134,"url":950,"thumbnailPath":28,"statistic":28,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"country":2106,"eissn":2107,"issn":2108,"title":2109},{"VOID":875},{"VOID":877},{"VOID":879},{"EN":881},[2111,2115,2119],{"id":887,"createTime":28,"updateTime":28,"relativeEntities":2112,"label":2113,"description":2114,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},{"id":893,"createTime":28,"updateTime":28,"relativeEntities":2116,"label":2117,"description":2118,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":896},{},{"id":899,"createTime":28,"updateTime":28,"relativeEntities":2120,"label":2121,"description":2122,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":902},{},[2124,2129],{"id":906,"createTime":28,"updateTime":28,"relativeEntities":2125,"slug":28,"properties":2126,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2128,"statistic":28},[],{"title":2127},{"EN":910},[],{"id":913,"createTime":28,"updateTime":28,"relativeEntities":2130,"slug":28,"properties":2131,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2133,"statistic":28},[],{"title":2132},{"EN":917},[],[2135,2142],{"id":921,"indexDatabase":2136,"url":933,"indexYears":28,"academicFieldIds":2141,"indexDatabaseRanking":28},{"id":923,"createTime":28,"updateTime":28,"relativeEntities":2137,"label":2138,"description":2139,"key":930,"publicationTags":2140,"standard":28},[],{"EN":926,"VI":926},{"EN":928,"VI":929},[932,813],[935],{"id":937,"indexDatabase":2143,"url":943,"indexYears":944,"academicFieldIds":2148,"indexDatabaseRanking":949},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":2144,"label":2145,"description":2146,"key":781,"publicationTags":2147,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[946,947,948],{"issue":2150,"pages":2151,"volume":2153},{"VOID":1432},{"VOID":2152},"303-314",{"VOID":2154},"107",2688,{"total":2155,"publishYear":2157,"statisticByYear":2158},1980,{"2012":45,"2013":46,"2014":40,"2015":40,"2016":42,"2017":40,"2018":123,"2019":40,"2021":40,"2022":123,"2023":40},"1980-06-01",[932],[2162,2165,2168,2170,2173,2177,2180,2183,2186,2189,2192,2194,2196,2199,2201,2204,2208,2211,2214,2217,2220,2223,2226,2229,2233,2236,2239,2242,2245,2248,2251],{"id":28,"text":2163,"url":28,"identifiers":2164},"10.1126\u002Fscience.99815",{"doi":2163},{"id":28,"text":2166,"url":28,"identifiers":2167},"10.1038\u002F280370a0",{"doi":2166},{"id":28,"text":1643,"url":28,"identifiers":2169},{"doi":1643},{"id":28,"text":2171,"url":28,"identifiers":2172},"10.1021\u002Fbi00602a022",{"doi":2171},{"id":28,"text":2174,"url":28,"identifiers":2175},"Ono M., 1977, J. Biochem. (Tokyo), 81, 949, 10.1093\u002Foxfordjournals.jbchem.a131560",{"doi":2176},"10.1093\u002Foxfordjournals.jbchem.a131560",{"id":28,"text":2178,"url":28,"identifiers":2179},"10.1016\u002F0022-2836(76)90337-5",{"doi":2178},{"id":28,"text":2181,"url":28,"identifiers":2182},"10.1073\u002Fpnas.69.7.1967",{"doi":2181},{"id":28,"text":2184,"url":28,"identifiers":2185},"10.1016\u002F0003-9861(76)90049-7",{"doi":2184},{"id":28,"text":2187,"url":28,"identifiers":2188},"10.1073\u002Fpnas.59.3.777",{"doi":2187},{"id":28,"text":2190,"url":28,"identifiers":2191},"10.1016\u002FS0300-9084(77)80290-3",{"doi":2190},{"id":28,"text":1496,"url":28,"identifiers":2193},{"doi":1496},{"id":28,"text":1321,"url":28,"identifiers":2195},{"doi":1321},{"id":28,"text":2197,"url":28,"identifiers":2198},"10.1016\u002FS0021-9258(19)41496-8",{"doi":2197},{"id":28,"text":1209,"url":28,"identifiers":2200},{"doi":1209},{"id":28,"text":2202,"url":28,"identifiers":2203},"10.1021\u002Fbi00688a010",{"doi":2202},{"id":28,"text":2205,"url":28,"identifiers":2206},"Rougeon F., 1977, J. Biol. Chem., 252, 2209, 10.1016\u002FS0021-9258(17)40543-6",{"doi":2207},"10.1016\u002FS0021-9258(17)40543-6",{"id":28,"text":2209,"url":28,"identifiers":2210},"10.1016\u002F0378-1119(77)90000-2",{"doi":2209},{"id":28,"text":2212,"url":28,"identifiers":2213},"10.1128\u002Fjb.114.2.577-591.1973",{"doi":2212},{"id":28,"text":2215,"url":28,"identifiers":2216},"10.1038\u002Fnewbio230172a0",{"doi":2215},{"id":28,"text":2218,"url":28,"identifiers":2219},"10.1038\u002Fnewbio244236a0",{"doi":2218},{"id":28,"text":2221,"url":28,"identifiers":2222},"10.1016\u002F0005-2787(76)90228-8",{"doi":2221},{"id":28,"text":2224,"url":28,"identifiers":2225},"10.1016\u002F0003-2697(77)90647-9",{"doi":2224},{"id":28,"text":2227,"url":28,"identifiers":2228},"10.1016\u002F0005-2787(76)90355-5",{"doi":2227},{"id":28,"text":2230,"url":28,"identifiers":2231},"Barber B. H., 1978, J. Immunol., 122, 320, 10.4049\u002Fjimmunol.122.1.320",{"doi":2232},"10.4049\u002Fjimmunol.122.1.320",{"id":28,"text":2234,"url":28,"identifiers":2235},"10.1021\u002Fbi00706a016",{"doi":2234},{"id":28,"text":2237,"url":28,"identifiers":2238},"10.1016\u002F0076-6879(67)12123-X",{"doi":2237},{"id":28,"text":2240,"url":28,"identifiers":2241},"10.1021\u002Fbi00643a026",{"doi":2240},{"id":28,"text":2243,"url":28,"identifiers":2244},"10.1016\u002F0092-8674(78)90072-7",{"doi":2243},{"id":28,"text":2246,"url":28,"identifiers":2247},"10.1016\u002FS0021-9258(19)41035-1",{"doi":2246},{"id":28,"text":2249,"url":28,"identifiers":2250},"10.1111\u002Fj.1432-1033.1978.tb20897.x",{"doi":2249},{"id":28,"text":2252,"url":28,"identifiers":2253},"10.1021\u002Fbi00670a013",{"doi":2252},{"id":2255,"createTime":2256,"updateTime":2257,"relativeEntities":2258,"slug":2259,"properties":2260,"entityType":978,"verifyStatus":26,"verifyTime":2256,"verifyNote":979,"languages":2276,"translateLanguages":2277,"viewCount":32,"primaryUrl":2278,"fullTextUrl":28,"authors":2279,"publicationType":1018,"publisherRelationship":2316,"citationCount":2369,"citationInfo":2370,"publishDate":2377,"publishYear":1809,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":2378,"openAccess":28,"references":2379,"isForceReanalyzing":1186},"e045cfeb-eb05-45d4-9400-81d9e061dc01","2024-09-21T06:09:15.375+00:00","2025-02-14T03:02:49.629+00:00",[],"Physiological-functions-of-thioredoxin-and-thioredoxin-reductase",{"mag":2261,"keywords":2263,"openalex":2264,"abstract":2266,"title":2269,"pm":2272,"doi":2274},{"VOID":2262},"2103650142",{"VI":1484},{"VOID":2265},"W2103650142",{"EN":2267,"VI":2268},"\u003Cjats:p>Thioredoxin, thioredoxin reductase and NADPH, the thioredoxin system, is ubiquitous from Archea to man. Thioredoxins, with a dithiol\u002Fdisulfide active site (CGPC) are the major cellular protein disulfide reductases; they therefore also serve as electron donors for enzymes such as ribonucleotide reductases, thioredoxin peroxidases (peroxiredoxins) and methionine sulfoxide reductases. Glutaredoxins catalyze glutathione‐disulfide oxidoreductions overlapping the functions of thioredoxins and using electrons from NADPH via glutathione reductase. Thioredoxin isoforms are present in most organisms and mitochondria have a separate thioredoxin system. Plants have chloroplast thioredoxins, which via ferredoxin–thioredoxin reductase regulates photosynthetic enzymes by light. Thioredoxins are critical for redox regulation of protein function and signaling via thiol redox control. A growing number of transcription factors including NF‐κB or the Ref‐1‐dependent AP1 require thioredoxin reduction for DNA binding. The cytosolic mammalian thioredoxin, lack of which is embryonically lethal, has numerous functions in defense against oxidative stress, control of growth and apoptosis, but is also secreted and has co‐cytokine and chemokine activities. Thioredoxin reductase is a specific dimeric 70‐kDa flavoprotein in bacteria, fungi and plants with a redox active site disulfide\u002Fdithiol. In contrast, thioredoxin reductases of higher eukaryotes are larger (112–130 kDa), selenium‐dependent dimeric flavoproteins with a broad substrate specificity that also reduce nondisulfide substrates such as hydroperoxides, vitamin C or selenite. All mammalian thioredoxin reductase isozymes are homologous to glutathione reductase and contain a conserved C‐terminal elongation with a cysteine–selenocysteine sequence forming a redox‐active selenenylsulfide\u002Fselenolthiol active site and are inhibited by goldthioglucose (aurothioglucose) and other clinically used drugs.\u003C\u002Fjats:p>","\u003Cjats:p>Thioredoxin, thioredoxin reductase và NADPH, hệ thống thioredoxin, tồn tại phổ biến từ Archea đến con người. Thioredoxin, với vị trí hoạt động dithiol\u002Fdisulfide (CGPC) là các khử disulfide protein chính trong tế bào; do đó, chúng cũng đóng vai trò là don electron cho các enzyme như ribonucleotide reductases, thioredoxin peroxidases (peroxiredoxins) và methionine sulfoxide reductases. Glutaredoxins xúc tác phản ứng oxy hóa-khử glutathione-disulfide, chồng lắp chức năng của thioredoxins và sử dụng electron từ NADPH thông qua glutathione reductase. Các isoform thioredoxin có mặt ở hầu hết các sinh vật và ti thể có một hệ thống thioredoxin riêng biệt. Cây có thioredoxin trong lục lạp, mà thông qua ferredoxin-thioredoxin reductase điều chỉnh các enzyme quang hợp bằng ánh sáng. Thioredoxins rất quan trọng cho sự điều hòa redox của chức năng protein và tín hiệu thông qua kiểm soát redox thiol. Số lượng ngày càng tăng của các yếu tố phiên mã như NF-κB hoặc AP1 phụ thuộc vào Ref-1 đòi hỏi sự khử thioredoxin để gắn DNA. Thioredoxin trong tế bào chất của động vật có vú, thiếu hụt gây chết phôi, có nhiều chức năng trong việc chống lại stress oxy hóa, kiểm soát tăng trưởng và apoptosis, nhưng cũng được tiết ra và có hoạt động đồng-cytokine và chemokine. Thioredoxin reductase là một flavoprotein dimmer đặc hiệu 70-kDa ở vi khuẩn, nấm và thực vật với vị trí hoạt động redox disulfide\u002Fdithiol. Ngược lại, thioredoxin reductases ở động vật bậc cao lớn hơn (112-130 kDa), phụ thuộc selen, là flavoproteins dimmer với đặc điểm cơ chất rộng rãi, cũng khử các cơ chất không thuộc disulfide như hydroperoxides, vitamin C hoặc selenite. Tất cả các isozyme thioredoxin reductase của động vật có vú đều đồng hình với glutathione reductase và có một đuôi C-terminus được bảo tồn với chuỗi cysteine-selenocysteine hình thành vị trí hoạt động selenenylsulfide\u002Fselenolthiol hoạt động redox và bị ức chế bởi goldthioglucose (aurothioglucose) và các thuốc được sử dụng lâm sàng khác.\u003C\u002Fjats:p>",{"EN":2270,"VI":2271},"Physiological functions of thioredoxin and thioredoxin reductase","Chức năng sinh lý của thioredoxin và thioredoxin reductase",{"VOID":2273},"11012661",{"VOID":2275},"10.1046\u002Fj.1432-1327.2000.01701.x",[31],[30],"https:\u002F\u002Ffebs.onlinelibrary.wiley.com\u002Fdoi\u002F10.1046\u002Fj.1432-1327.2000.01701.x",[2280,2299],{"id":2281,"sortIndex":32,"researcher":28,"roles":2282,"affiliations":2283,"properties":2292},"ab022618-c45f-49e2-9482-6e0746aab3bd",[],[2284],{"id":2285,"sortIndex":32,"affiliation":2286,"properties":28},"c39595ba-27e3-4824-8ea8-95e4a1555dc4",{"id":2285,"createTime":28,"updateTime":28,"relativeEntities":2287,"slug":28,"properties":2288,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2291,"statistic":28},[],{"title":2289},{"EN":2290},"Medical Nobel Institute for Biochemistry, Dept. of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden",[],{"orcid":2293,"title":2295,"openalex":2297},{"VOID":2294},"https:\u002F\u002Forcid.org\u002F0000-0002-4807-6114",{"EN":2296},"Elias S.J. Arnér",{"VOID":2298},"A5012576392",{"id":2300,"sortIndex":40,"researcher":28,"roles":2301,"affiliations":2302,"properties":2309},"5281941a-0f89-45a4-9363-8348ca2346c4",[],[2303],{"id":2285,"sortIndex":32,"affiliation":2304,"properties":28},{"id":2285,"createTime":28,"updateTime":28,"relativeEntities":2305,"slug":28,"properties":2306,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2308,"statistic":28},[],{"title":2307},{"EN":2290},[],{"orcid":2310,"title":2312,"openalex":2314},{"VOID":2311},"https:\u002F\u002Forcid.org\u002F0000-0001-5046-1815",{"EN":2313},"Arne Holmgren",{"VOID":2315},"A5079550858",{"url":28,"publisher":2317,"properties":2363},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":2318,"slug":872,"properties":2319,"entityType":25,"verifyStatus":884,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":2324,"manageAffiliations":2337,"indexDatabases":2348,"url":950,"thumbnailPath":28,"statistic":28,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"country":2320,"eissn":2321,"issn":2322,"title":2323},{"VOID":875},{"VOID":877},{"VOID":879},{"EN":881},[2325,2329,2333],{"id":887,"createTime":28,"updateTime":28,"relativeEntities":2326,"label":2327,"description":2328,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},{"id":893,"createTime":28,"updateTime":28,"relativeEntities":2330,"label":2331,"description":2332,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":896},{},{"id":899,"createTime":28,"updateTime":28,"relativeEntities":2334,"label":2335,"description":2336,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":902},{},[2338,2343],{"id":906,"createTime":28,"updateTime":28,"relativeEntities":2339,"slug":28,"properties":2340,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2342,"statistic":28},[],{"title":2341},{"EN":910},[],{"id":913,"createTime":28,"updateTime":28,"relativeEntities":2344,"slug":28,"properties":2345,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2347,"statistic":28},[],{"title":2346},{"EN":917},[],[2349,2356],{"id":921,"indexDatabase":2350,"url":933,"indexYears":28,"academicFieldIds":2355,"indexDatabaseRanking":28},{"id":923,"createTime":28,"updateTime":28,"relativeEntities":2351,"label":2352,"description":2353,"key":930,"publicationTags":2354,"standard":28},[],{"EN":926,"VI":926},{"EN":928,"VI":929},[932,813],[935],{"id":937,"indexDatabase":2357,"url":943,"indexYears":944,"academicFieldIds":2362,"indexDatabaseRanking":949},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":2358,"label":2359,"description":2360,"key":781,"publicationTags":2361,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[946,947,948],{"issue":2364,"pages":2366,"volume":2368},{"VOID":2365},"20",{"VOID":2367},"6102-6109",{"VOID":1806},2408,{"total":2369,"publishYear":1809,"statisticByYear":2371},{"2012":2372,"2013":2373,"2014":2374,"2015":430,"2016":209,"2017":2375,"2018":329,"2019":2376,"2020":2374,"2021":2372,"2022":435,"2023":332,"2024":567},124,112,120,101,96,"2000-10-01",[932],[2380,2383,2386,2389,2392,2395,2398,2401,2405,2409,2412,2415,2418,2421,2424,2427,2430,2433,2436,2439,2442,2445,2448,2451,2454,2457,2460,2463,2466,2470,2474,2478,2481,2484,2488,2491,2494,2497,2500,2503,2506,2509,2512,2515,2518,2521,2524,2527,2530,2533,2536,2539,2542,2545,2548,2551,2554,2557,2560,2563,2566,2569,2572,2575,2578,2581,2584,2587,2590,2593,2596,2599,2602,2605,2608,2611,2614,2617,2620,2623,2626,2629,2632,2635,2638],{"id":28,"text":2381,"url":28,"identifiers":2382},"10.1002\u002F9780470123096.ch2",{"doi":2381},{"id":28,"text":2384,"url":28,"identifiers":2385},"10.1146\u002Fannurev.bi.54.070185.001321",{"doi":2384},{"id":28,"text":2387,"url":28,"identifiers":2388},"Williams C.H. Jr, 1992, Chemistry and Biochemistry of Flavoenzymes, 121",{},{"id":28,"text":2390,"url":28,"identifiers":2391},"10.1016\u002FS0021-9258(18)71625-6",{"doi":2390},{"id":28,"text":2393,"url":28,"identifiers":2394},"10.1016\u002FS0969-2126(01)00153-8",{"doi":2393},{"id":28,"text":2396,"url":28,"identifiers":2397},"10.1016\u002FS0076-6879(99)00129-9",{"doi":2396},{"id":28,"text":2399,"url":28,"identifiers":2400},"10.1016\u002Fs0968-0004(98)01335-8",{"doi":2399},{"id":28,"text":2402,"url":28,"identifiers":2403},"Huber H.E., 1987, Escherichia coli thioredoxin stabilizes complexes of bacteriophage T7 DNA polymerase and primed templates, J. Biol. Chem., 262, 16224, 10.1016\u002FS0021-9258(18)47719-8",{"doi":2404},"10.1016\u002FS0021-9258(18)47719-8",{"id":28,"text":2406,"url":28,"identifiers":2407},"Russel M., 1986, The role of thioredoxin in filamentous phage assembly. Construction, isolation and characterization of mutant thioredoxins, J. Biol. 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A., 2000, Thioredoxin reductase, a redox‐active selenoprotein, is secreted by normal and neoplastic cells: presence in human plasma, Cancer Res., 60, 2281",{},{"id":28,"text":2585,"url":28,"identifiers":2586},"10.1042\u002F0264-6021:3470661",{"doi":2585},{"id":28,"text":2588,"url":28,"identifiers":2589},"10.1016\u002FS0021-9258(18)97742-2",{"doi":2588},{"id":28,"text":2591,"url":28,"identifiers":2592},"10.1111\u002Fj.1432-1033.1968.tb00470.x",{"doi":2591},{"id":28,"text":2594,"url":28,"identifiers":2595},"10.1016\u002F0076-6879(84)07019-1",{"doi":2594},{"id":28,"text":2597,"url":28,"identifiers":2598},"10.1093\u002Femboj\u002F17.19.5543",{"doi":2597},{"id":28,"text":2600,"url":28,"identifiers":2601},"10.1016\u002FS0076-6879(99)00128-7",{"doi":2600},{"id":28,"text":2603,"url":28,"identifiers":2604},"10.1073\u002Fpnas.96.3.887",{"doi":2603},{"id":28,"text":2606,"url":28,"identifiers":2607},"Brot N., 1991, Biochemistry of methionine sulfoxide residues in proteins, Biofactors, 3, 91",{},{"id":28,"text":2609,"url":28,"identifiers":2610},"10.1046\u002Fj.1365-2958.1999.01636.x",{"doi":2609},{"id":28,"text":2612,"url":28,"identifiers":2613},"10.1074\u002Fjbc.274.12.7695",{"doi":2612},{"id":28,"text":2615,"url":28,"identifiers":2616},"10.1007\u002FBF00408300",{"doi":2615},{"id":28,"text":2618,"url":28,"identifiers":2619},"10.1016\u002F0003-9861(91)90157-E",{"doi":2618},{"id":28,"text":2621,"url":28,"identifiers":2622},"10.1016\u002F0891-5849(92)90165-D",{"doi":2621},{"id":28,"text":2624,"url":28,"identifiers":2625},"10.1093\u002Fmolehr\u002F4.4.369",{"doi":2624},{"id":28,"text":2627,"url":28,"identifiers":2628},"10.1152\u002Fajplung.1999.276.3.L530",{"doi":2627},{"id":28,"text":2630,"url":28,"identifiers":2631},"10.1016\u002F0006-8993(94)90241-0",{"doi":2630},{"id":28,"text":2633,"url":28,"identifiers":2634},"10.1074\u002Fjbc.272.29.18044",{"doi":2633},{"id":28,"text":2636,"url":28,"identifiers":2637},"10.1016\u002F0888-7543(95)80223-9",{"doi":2636},{"id":28,"text":2639,"url":28,"identifiers":2640},"10.1016\u002FS0021-9258(19)37617-3",{"doi":2639},{"id":2642,"createTime":2643,"updateTime":2644,"relativeEntities":2645,"slug":2646,"properties":2647,"entityType":978,"verifyStatus":26,"verifyTime":2643,"verifyNote":979,"languages":2663,"translateLanguages":2664,"viewCount":32,"primaryUrl":2665,"fullTextUrl":28,"authors":2666,"publicationType":1018,"publisherRelationship":2686,"citationCount":2739,"citationInfo":2740,"publishDate":2743,"publishYear":2741,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":2744,"openAccess":28,"references":2745,"isForceReanalyzing":1186},"c4f408ca-173a-4dc5-91b6-425e71b5c309","2024-10-16T21:44:24.344+00:00","2025-02-14T03:03:44.477+00:00",[],"Patterns-of-Amino-Acids-near-Signal-Sequence-Cleavage-Sites",{"mag":2648,"keywords":2650,"openalex":2651,"abstract":2653,"title":2656,"pm":2659,"doi":2661},{"VOID":2649},"2042096080",{"VI":1484},{"VOID":2652},"W2042096080",{"EN":2654,"VI":2655},"\u003Cjats:p>According to the signal hypothesis, a signal sequence, once having initiated export of a growing protein chain across the rough endoplasmic reticulum, is cleaved from the mature protein at a specific site. It has long been known that some part of the cleavage specificity resides in the last residue of the signal sequence, which invariably is one with a small, uncharged side‐chain, but no further specific patterns of amino acids near the point of cleavage have been discovered so far. In this paper, some such patterns, based on a sample of 78 eukaryotic signal sequences, are presented and discussed, and a first attempt at formulating rules for the prediction of cleavage sites is made.\u003C\u002Fjats:p>","\u003Cjats:p>Theo giả thuyết tín hiệu, một chuỗi tín hiệu, sau khi khởi đầu xuất khẩu của một chuỗi protein đang tăng trưởng qua mạng lưới nội chất thô, sẽ được cắt ra khỏi protein trưởng thành tại một vị trí cụ thể. Đã có một thời gian dài cho rằng một phần của tính đặc hiệu cắt gắn liền với dư lượng cuối cùng của chuỗi tín hiệu, và nó luôn là một dư lượng chứa chuỗi bên nhỏ, không mang điện. Tuy nhiên, cho đến nay, chưa phát hiện được thêm các mẫu cụ thể về amin gần điểm cắt. Trong bài báo này, một số mẫu như vậy, dựa trên một mẫu 78 chuỗi tín hiệu eukaryotic, được trình bày và thảo luận, cùng với nỗ lực đầu tiên trong việc xây dựng quy tắc để dự đoán các vị trí cắt.",{"EN":2657,"VI":2658},"Patterns of Amino Acids near Signal‐Sequence Cleavage Sites","Mô hình Amino Acids Gần Các Vị Trí Cắt Tín 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Sweden",[],{"orcid":2680,"title":2682,"openalex":2684},{"VOID":2681},"https:\u002F\u002Forcid.org\u002F0000-0002-4490-8569",{"EN":2683},"Gunnar von 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Defense strategies include three levels of protection; prevention, interception, and repair. Regulation of the antioxidant capacity includes the maintenance of adequate levels of antioxidant and the localization of antioxidant compounds and enzymes. Short‐term and long‐term adaptation and cell specialisation in these functions are new areas of interest. Control over the activity of prooxidant enzymes, such as NADPH oxidase and NO synthases, is crucial. Synthetic antioxidants mimic biological strategies.\u003C\u002Fjats:p>","\u003Cjats:p>Bảo vệ tế bào chống lại các tác động có hại của các chất oxy hóa phản ứng được sinh ra trong chuyển hóa hiếu khí, gọi là stress oxy hóa, được tổ chức ở nhiều cấp độ khác nhau. Các chiến lược phòng thủ bao gồm ba cấp độ bảo vệ: ngăn ngừa, chặn lại và sửa chữa. Việc điều chỉnh khả năng chống oxy hóa bao gồm việc duy trì mức độ hợp lý của các chất chống oxy hóa và vị trí của các hợp chất và enzyme chống oxy hóa. Sự thích nghi ngắn hạn và dài hạn cũng như chuyên biệt hóa tế bào trong các chức năng này là những lĩnh vực quan tâm mới. Kiểm soát hoạt động của các enzyme gây oxy hóa, chẳng hạn như NADPH oxidase và NO synthases, là rất quan trọng. Các chất chống oxy hóa tổng hợp mô phỏng các chiến lược sinh học.\u003C\u002Fjats:p>",{"EN":2947,"VI":2948},"Strategies of antioxidant defense","Các chiến lược phòng thủ chống oxi hóa",{"VOID":2950},"7688300",{"VOID":2952},"10.1111\u002Fj.1432-1033.1993.tb18025.x","2024-09-18T19:57:37.285+00:00",[31],[30],"https:\u002F\u002Ffebs.onlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1432-1033.1993.tb18025.x",[2958],{"id":2959,"sortIndex":32,"researcher":28,"roles":2960,"affiliations":2961,"properties":2970},"042180e0-b349-461c-9433-15b9371ea856",[],[2962],{"id":2963,"sortIndex":32,"affiliation":2964,"properties":28},"6cc37ffe-3dbf-4d4d-9971-1a408a1823f4",{"id":2963,"createTime":28,"updateTime":28,"relativeEntities":2965,"slug":28,"properties":2966,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2969,"statistic":28},[],{"title":2967},{"VI":2968},"Institut für Physiologische Chemie I, Heinrich 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