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JM, Jenkins NW, Parrish MS et al (2021) The influence of cognitive behavioral therapy on lumbar spine surgery outcomes: a systematic review and meta-analysis. 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Contemp Clin Trials 45((Pt A)):130–138",{"doi":314},false,{"id":329,"createTime":330,"updateTime":331,"relativeEntities":332,"slug":333,"properties":334,"entityType":215,"verifyStatus":216,"verifyTime":345,"verifyNote":218,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":346,"fullTextUrl":18,"authors":347,"publicationType":251,"publisherRelationship":441,"citationCount":492,"citationInfo":493,"publishDate":496,"publishYear":494,"citationAnalyzeStatus":305,"lastCitationAnalyze":497,"indexDatabases":498,"openAccess":18,"references":18,"isForceReanalyzing":327},"df9af55a-0df7-4c5f-811b-bf9422d8a173","2024-01-14T03:15:58.460+00:00","2026-08-19T09:59:27.800+00:00",[],"Non-fusion-and-growing-instrumentation-in-the-correction-of-congenital-spinal-deformity-associated-with-split-spinal-cord-malformation-an-early-follow-up-outcome",{"abstract":335,"title":337,"gsPaper":339,"references":341,"doi":343},{"EN":336},"A retrospective case review. To evaluate the safety and efficacy of the non-fusion technique in achieving and maintaining the proper correction for congenital spinal deformity (CSD) and allowing normal spinal growth in patients with split spinal cord malformation (SSCM). Seven patients who had CSD and SSCM were adopted, with a mean age of 8 years. All the patients in this study received Halo-gravity traction (HGT) prior to expansion of the spine and instrumentation with vertical expandable titanium prosthetic rib, growing rod or their hybrid. Five of them underwent opening wedge thoracoplasty simultaneously. And the two patients with type I SSCM underwent bony spur excision in the initial surgery before corrective manipulation. Then all the patients received a lengthened operation every six months. Changes of their major curve and length of T1–S1 spine were measured, and complications, neurological status were recorded. All the patients were followed up with an average of 32.6 months. Their mean major curve improved from 90.1° to 58.6° with a correction rate of 34.9 %. The T1–S1 length increased from 26.3 to 34.7 cm at final follow-up. Especially, one of the type I SSCM patients whose neurological deterioration was found preoperatively was significantly improved. Preoperative Halo-gravity traction followed by non-fusion and growing instrumentation may be effective and safe for young children of CSD associated with SSCM. But it is an ongoing study and additional large multicenter studies are necessary to further assess the safety and efficacy of non-fusion and growing instrumentation.",{"EN":338},"Non-fusion and growing instrumentation in the correction of congenital spinal deformity associated with split spinal cord malformation: an early follow-up outcome",{"VOID":340},"[\"12767465166082673667\"]",{"VOID":342},"Hensinger RN (2009) Congenital scoliosis: etiology and associations. Spine (Phila Pa 1976) 34(17):1745–1750\nYazici M, Emans J (2009) Fusionless instrumentation systems for congenital scoliosis: expandable spinal rods and vertical expandable prosthetic titanium rib in the management of congenital spine deformities in the growing child. Spine (Phila Pa 1976) 34(17):1800–1807\nMarks DS, Qaimkhani SA (2009) The natural history of congenital scoliosis and kyphosis. Spine (Phila Pa 1976) 34(17):1751–1755\nArlet V, Odent T, Aebi M (2003) Congenital scoliosis. Eur Spine J 12(5):456–463\nWinter RB, Lonstein JE, Boachie-Adjei O (1996) Congenital spinal deformity. Instr Course Lect 45:117–127\nHedequist DJ (2009) Instrumentation and fusion for congenital spine deformities. Spine (Phila Pa 1976) 34(17):1783–1790\nSinha S, Agarwal D, Mahapatra AK (2006) Split cord malformations: an experience of 203 cases. Childs Nerv Syst 22(1):3–7\nWinter RB et al (1974) Diastematomyelia and congenital spine deformities. J Bone Joint Surg Am 56(1):27–39\nMaruyama T, Takeshita K (2008) Surgical treatment of scoliosis: a review of techniques currently applied. Scoliosis 3:6\nCampbell RM Jr et al (2003) The characteristics of thoracic insufficiency syndrome associated with fused ribs and congenital scoliosis. J Bone Joint Surg Am 85(A3):399–408\nCampbell RM Jr, Hell-Vocke AK (2003) Growth of the thoracic spine in congenital scoliosis after expansion thoracoplasty. J Bone Joint Surg Am 85(A3):409–420\nCampbell RM Jr et al (2004) The effect of opening wedge thoracostomy on thoracic insufficiency syndrome associated with fused ribs and congenital scoliosis. J Bone Joint Surg Am 86(A8):1659–1674\nPang D, Dias MS, Ahab-Barmada M (1992) Split cord malformation: part I: a unified theory of embryogenesis for double spinal cord malformations. Neurosurgery 31(3):451–480\nPang D (2001) Ventral tethering in split cord malformation. Neurosurg Focus 10(1):e6\nPang D (1992) Split cord malformation: part II: clinical syndrome. Neurosurgery 31(3):481–500\nQureshi MA et al (2009) Staged corrective surgery for complex congenital scoliosis and split cord malformation. Eur Spine J 18(9):1249–1254\nNoordeen MH et al (2009) The surgical treatment of congenital kyphosis. Spine (Phila Pa 1976) 34(17):1808–1814\nSink EL et al (2001) Efficacy of perioperative halo-gravity traction in the treatment of severe scoliosis in children. J Pediatr Orthop 21(4):519–524\nKoller H et al (2012) The impact of halo-gravity traction on curve rigidity and pulmonary function in the treatment of severe and rigid scoliosis and kyphoscoliosis: a clinical study and narrative review of the literature. Eur Spine J 21(3):514–529\nBouchoucha S, Khelifi A, Saied W, Ammar C, Nessib MN, Ben Ghachem M (2011) Progressive correction of severe spinal deformities with halo-gravity traction. Acta Orthop Belg 77(4):529–534\nMoe JH et al (1984) Harrington instrumentation without fusion plus external orthotic support for the treatment of difficult curvature problems in young children. Clin Orthop Relat Res 185:35–45\nKlemme WR et al (1997) Spinal instrumentation without fusion for progressive scoliosis in young children. J Pediatr Orthop 17(6):734–742\nMineiro J, Weinstein SL (2002) Subcutaneous rodding for progressive spinal curvatures: early results. J Pediatr Orthop 22(3):290–295\nAkbarnia BA et al (2005) Dual growing rod technique for the treatment of progressive early-onset scoliosis: a multicenter study. Spine (Phila Pa 1976) 30(17 Suppl):S46–S57\nSchijman E (2003) Split spinal cord malformations: report of 22 cases and review of the literature. Childs Nerv Syst 19(2):96–103\nYamada S, Won DJ (2007) What is the true tethered cord syndrome? Childs Nerv Syst 23(4):371–375\nAyvaz M et al (2009) Is it necessary to operate all split cord malformations before corrective surgery for patients with congenital spinal deformities? Spine (Phila Pa 1976) 34(22):2413–2418\nHamzaoglu A et al (2007) Simultaneous surgical treatment in congenital scoliosis and\u002For kyphosis associated with intraspinal abnormalities. Spine (Phila Pa 1976) 32(25):2880–2884\nCampbell RM Jr et al (2007) The effect of mid-thoracic VEPTR opening wedge thoracostomy on cervical tilt associated with congenital thoracic scoliosis in patients with thoracic insufficiency syndrome. 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This fact rises the question about the interactions and the evolutionary relevance of this phenomenon. It has been described that these relatively large notochordal cells are mainly dominant in early lifetime of all vertebrates and then differences occur with ageing. Human, cattle, sheep, and goat lose the cells with age, whereas rodents and lagomorphs maintain these throughout their lifetime. Here, we addressed the importance of cell ratio using alginate bead 3-D co-culture of bovine nucleus pulposus cells (bNPC) and porcine notochordal cells (pNCs) for 14 days using culture inserts. We found a significant stimulation of bNPC in the presence of pNC in terms of cell activity and glycosaminoglycan production, but not for proliferation (DNA content). Relative gene expression was significantly stimulated for collagen type 2 and aggrecan. The stimulating effect of NC was confirmed and the ideal ratio of NPC: NC was found to be ~50:50. This has direct implications for tissue-engineering approaches, which aim to repopulate discs with NP-like precursor cells.",{"EN":784},"The evolutionary importance of cell ratio between notochordal and nucleus pulposus cells: an experimental 3-D co-culture study",{"VOID":786},"[\"14996721785961352527\"]",{"VOID":788},"10.1007\u002Fs00586-011-2026-9","2024-04-29T17:51:49.063+00:00","http:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs00586-011-2026-9",[792,809],{"id":793,"sortIndex":19,"researcher":18,"roles":794,"affiliations":795,"properties":804,"displayName":806,"givenName":18,"familyName":18},"7e0f553b-d5b7-4b5b-938f-b583385cf7ea",[224],[796],{"id":797,"sortIndex":19,"affiliation":798,"properties":18},"ee706dca-c65f-4029-8a07-33f1cf8273f9",{"id":797,"createTime":18,"updateTime":18,"relativeEntities":799,"slug":18,"properties":800,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":803,"statistic":18},[],{"title":801},{"VI":802},"ARTORG Center for Biomedical Engineering Research, Institute for Surgical Technology and Biomechanics, Medical Faculty, University of Bern, Bern, Switzerland",[],{"title":805,"gsAuthor":807},{"VI":806},"Benjamin Gantenbein-Ritter",{"VOID":808},"[\"35fgj-EAAAAJ\"]",{"id":810,"sortIndex":239,"researcher":18,"roles":811,"affiliations":812,"properties":819,"displayName":821,"givenName":18,"familyName":18},"d73615b0-b81a-4b11-abf5-073f57805378",[224],[813],{"id":797,"sortIndex":19,"affiliation":814,"properties":18},{"id":797,"createTime":18,"updateTime":18,"relativeEntities":815,"slug":18,"properties":816,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":818,"statistic":18},[],{"title":817},{"VI":802},[],{"title":820,"gsAuthor":822},{"VI":821},"Samantha C. 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Exp Cell Res 246(1):129–137. doi:10.1006\u002Fexcr.1998.4287","https:\u002F\u002Fdoi.org\u002F10.1006\u002Fexcr.1998.4287",{"mag":887,"openalex":888,"pm":889,"doi":890},"1991192053","W1991192053","9882522","10.1006\u002Fexcr.1998.4287",{"id":310,"text":892,"url":312,"identifiers":893},"Ahmed SA, Gogal RM, Walsh JE (1994) A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H] thymidine incorporation assay. J Immunol Methods 170(2):211–224",{"doi":314},{"id":310,"text":895,"url":312,"identifiers":896},"Boyd LM, Chen J, Kraus VB, Setton LA (2004) Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral disc. Spine 29(20):2217–2222",{"doi":314},{"id":310,"text":898,"url":312,"identifiers":899},"Butler WF (1989) Comparative anatomy and development of the mammalian disc. In: Gosh P (ed) The biology of the intervertebral disc. CRC Press, Boca Raton, pp 84–108",{"doi":314},{"id":901,"text":902,"url":903,"identifiers":904},"9a26c92f-4d22-4f5a-ac31-2f581006a45c","Chen J, Yan W, Setton LA (2006) Molecular phenotypes of notochordal cells purified from immature nucleus pulposus. Eur Spine J 15(Suppl 3):S303–S311. doi:10.1007\u002Fs00586-006-0088-x","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00586-006-0088-x",{"doi":905},"10.1007\u002Fs00586-006-0088-x",{"id":310,"text":907,"url":312,"identifiers":908},"Doskocil M, Valouch P, Pazderka V (1993) On vertebral body growth. Funct Dev Morphol 3(3):149–155",{"doi":314},{"id":18,"text":910,"url":911,"identifiers":912},"Enobakhare BO, Bader DL, Lee DA (1996) Quantification of sulfated glycosaminoglycans in chondrocyte\u002Falginate cultures, by use of 1,9-dimethylmethylene blue. Anal Biochem 243(1):189–191. doi:10.1006\u002Fabio.1996.0502","http:\u002F\u002Fdx.doi.org\u002F10.1006\u002Fabio.1996.0502",{"doi":913},"10.1006\u002Fabio.1996.0502",{"id":915,"text":916,"url":917,"identifiers":918},"5f48f814-a436-41bb-9761-fb3c2539f20a","Erwin WM (2010) The enigma that is the nucleus pulposus cell: the search goes on. Arthritis Res Ther 12(3):118. doi:10.1186\u002Far3001","http:\u002F\u002Farthritis-research.biomedcentral.com\u002Farticles\u002F10.1186\u002Far3001",{"doi":919},"10.1186\u002Far3001",{"id":18,"text":921,"url":922,"identifiers":923},"Erwin WM, Ashman K, O’Donnel P, Inman RD (2006) Nucleus pulposus notochord cells secrete connective tissue growth factor and up-regulate proteoglycan expression by intervertebral disc chondrocytes. Arthritis Rheum 54(12):3859–3867. doi:10.1002\u002Fart.22258","https:\u002F\u002Fdoi.org\u002F10.1002\u002Fart.22258",{"mag":924,"openalex":925,"pm":926,"doi":927},"2117636006","W2117636006","17136753","10.1002\u002Fart.22258",{"id":18,"text":929,"url":930,"identifiers":931},"Erwin WM, Las Heras F, Islam D, Fehlings MG, Inman RD (2009) The regenerative capacity of the notochordal cell: tissue constructs generated in vitro under hypoxic conditions. J Neurosurg Spine 10(6):513–521. doi:10.3171\u002F2009.2.SPINE08578","https:\u002F\u002Fdoi.org\u002F10.3171\u002F2009.2.spine08578",{"mag":932,"openalex":933,"pm":934,"doi":935},"1548634968","W1548634968","19558283","10.3171\u002F2009.2.spine08578",{"id":937,"text":938,"url":939,"identifiers":940},"c739351c-e3c1-4016-beb5-21999a8f3603","Farndale RW, Buttle DJ, Barrett AJ (1986) Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue 1. Biochim Biophys Acta 883(2):173–177","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002F0304416586903065",{"doi":941},"10.1016\u002F0304-4165(86)90306-5",{"id":943,"text":944,"url":945,"identifiers":946},"15ed9fc4-df49-4f19-83da-26af476c8e4f","Faul F, Erdfelder E, Lang AG, Buchner A (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39(2):175–191","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.3758\u002FBF03193146",{"doi":947},"10.3758\u002FBF03193146",{"id":949,"text":950,"url":951,"identifiers":952},"eb3577df-b4c2-406a-a45e-0e1689be3e61","Gilson A, Dreger M, Urban JP (2010) Differential expression levels of cytokeratin 8 in cells of the bovine nucleus pulposus complicates the search for specific intervertebral disc cell markers. Arthritis Res Ther 12(1):R24. doi:10.1186\u002Far2931","https:\u002F\u002Farthritis-research.biomedcentral.com\u002Farticles\u002F10.1186\u002Far2931",{"doi":953},"10.1186\u002Far2931",{"id":955,"text":956,"url":957,"identifiers":958},"767c665b-180e-40e6-ae00-c88401a129d7","Guehring T, Nerlich A, Kroeber M, Richter W, Omlor GW (2010) Sensitivity of notochordal disc cells to mechanical loading: an experimental animal study. Eur Spine J 19(1):113–121. doi:10.1007\u002Fs00586-009-1217-0","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00586-009-1217-0",{"doi":959},"10.1007\u002Fs00586-009-1217-0",{"id":18,"text":961,"url":962,"identifiers":963},"Guehring T, Urban JP, Cui Z, Tirlapur UK (2008) Noninvasive 3D vital imaging and characterization of notochordal cells of the intervertebral disc by femtosecond near-infrared two-photon laser scanning microscopy and spatial-volume rendering. Microsc Res Tech 71(4):298–304. doi:10.1002\u002Fjemt.20557","https:\u002F\u002Fdoi.org\u002F10.1002\u002Fjemt.20557",{"mag":964,"openalex":965,"pm":966,"doi":967},"1978916791","W1978916791","18189326","10.1002\u002Fjemt.20557",{"id":18,"text":969,"url":970,"identifiers":971},"Guehring T, Wilde G, Sumner M, Grünhagen T, Karney GB, Tirlapur UK, Urban JP (2009) Notochordal intervertebral disc cells: sensitivity to nutrient deprivation. Arthritis Rheum 60(4):1026–1034. doi:10.1002\u002Fart.24407","https:\u002F\u002Fdoi.org\u002F10.1002\u002Fart.24407",{"mag":972,"openalex":973,"pm":974,"doi":975},"2133298632","W2133298632","19333932","10.1002\u002Fart.24407",{"id":18,"text":977,"url":18,"identifiers":978},"Horwitz T (1977) The human notochord: a study of its development and regression, variations, and pathologic derivative, chordoma. Horwitz: Indianapolis",{},{"id":310,"text":980,"url":312,"identifiers":981},"Hunter CJ, Bianchi S, Cheng P, Muldrew K (2007) Osmoregulatory function of large vacuoles found in notochordal cells of the intervertebral disc running title: an osmoregulatory vacuole. Mol Cell Biomech 4(4):227–237",{"doi":314},{"id":18,"text":983,"url":984,"identifiers":985},"Hunter CJ, Matyas JR, Duncan NA (2003) The notochordal cell in the nucleus pulposus: a review in the context of tissue engineering. Tissue Eng 9(4):667–677. doi:10.1089\u002F107632703768247368","https:\u002F\u002Fdoi.org\u002F10.1089\u002F107632703768247368",{"mag":986,"openalex":987,"pm":988,"doi":989},"2027990128","W2027990128","13678445","10.1089\u002F107632703768247368",{"id":18,"text":991,"url":992,"identifiers":993},"Hunter CJ, Matyas JR, Duncan NA (2004) Cytomorphology of notochordal and chondrocytic cells from the nucleus pulposus: a species comparison. J Anat 205(5):357–362. doi:10.1111\u002Fj.0021-8782.2004.00352.x","https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.0021-8782.2004.00352.x",{"mag":994,"pmc":995,"openalex":996,"pm":997,"doi":998},"2091573615","1571361","W2091573615","15575884","10.1111\u002Fj.0021-8782.2004.00352.x",{"id":18,"text":1000,"url":1001,"identifiers":1002},"Kim KW, Ha KY, Lee JS, Nam SW, Woo YK, Lim TH, An HS (2009) Notochordal cells stimulate migration of cartilage end plate chondrocytes of the intervertebral disc in in vitro cell migration assays. Spine J 9(4):323–329. doi:10.1016\u002Fj.spinee.2008.05.003","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.spinee.2008.05.003",{"mag":1003,"openalex":1004,"pm":1005,"doi":1006},"2074190254","W2074190254","18619909","10.1016\u002Fj.spinee.2008.05.003",{"id":1008,"text":1009,"url":1010,"identifiers":1011},"8fd533b0-be13-4008-88d9-72a87816e54d","Korecki CL, Taboas JM, Tuan RS, Iatridis JC (2010) Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype. Stem Cell Res Ther 1(2):18. doi:10.1186\u002Fscrt18","https:\u002F\u002Fstemcellres.biomedcentral.com\u002Farticles\u002F10.1186\u002Fscrt18",{"doi":1012},"10.1186\u002Fscrt18",{"id":18,"text":1014,"url":1015,"identifiers":1016},"Lee CR, Grad S, Maclean JJ, Iatridis JC, Alini M (2005) Effect of mechanical loading on mRNA levels of common endogenous controls in articular chondrocytes and intervertebral disk. Anal Biochem 341(2):372–375. doi:10.1016\u002Fj.ab.2004.10.005","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ab.2004.10.005",{"mag":1017,"openalex":1018,"pm":1019,"doi":1020},"2004058379","W2004058379","15907885","10.1016\u002Fj.ab.2004.10.005",{"id":18,"text":1022,"url":18,"identifiers":1023},"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25(4):402–408. doi:10.1006\u002Fmeth.2001.1262",{"doi":1024},"10.1006\u002Fmeth.2001.1262",{"id":310,"text":1026,"url":312,"identifiers":1027},"Maldonado BA, Oegema TR (1992) Initial characterization of the metabolism of intervertebral disc cells encapsulated in microspheres. J Orthop Res 10(5):677–690",{"doi":314},{"id":310,"text":1029,"url":312,"identifiers":1030},"Marino JH, Cook P, Miller KS (2003) Accurate and statistically verified quantification of relative mRNA abundances using SYBR Green I and real-time RT-PCR. J Immunol Methods 283(1–2):291–306",{"doi":314},{"id":18,"text":1032,"url":1033,"identifiers":1034},"Minogue BM, Richardson SM, Zeef LA, Freemont AJ, Hoyland JA (2010) Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes. Arthritis Res Ther 12(1):R22. doi:10.1186\u002Far2929","https:\u002F\u002Fdoi.org\u002F10.1186\u002Far2929",{"mag":1035,"pmc":1036,"openalex":1037,"pm":1038,"doi":1039},"2124694620","2875656","W2124694620","20149220","10.1186\u002Far2929",{"id":18,"text":1041,"url":1042,"identifiers":1043},"Miyazaki T, Kobayashi S, Takeno K, Meir A, Urban J, Baba H (2009) A phenotypic comparison of proteoglycan production of intervertebral disc cells isolated from rats, rabbits, and bovine tails; which animal model is most suitable to study tissue engineering and biological repair of human disc disorders? Tissue Eng Part A 15(12):3835–3846. doi:10.1089\u002Ften.tea.2009.0250","https:\u002F\u002Fdoi.org\u002F10.1089\u002Ften.tea.2009.0250",{"mag":1044,"openalex":1045,"pm":1046,"doi":1047},"2009033433","W2009033433","19681728","10.1089\u002Ften.tea.2009.0250",{"id":18,"text":1049,"url":1050,"identifiers":1051},"Oguz E, Tsai TT, Di Martino A, Guttapalli A, Albert TJ, Shapiro IM, Risbud MV (2007) Galectin-3 expression in the intervertebral disc: a useful marker of the notochord phenotype? Spine 32(1):9–16. doi:10.1097\u002F01.brs.0000250302.74574.98","https:\u002F\u002Fdoi.org\u002F10.1097\u002F01.brs.0000250302.74574.98",{"mag":1052,"openalex":1053,"pm":1054,"doi":1055},"1987114834","W1987114834","17202886","10.1097\u002F01.brs.0000250302.74574.98",{"id":18,"text":1057,"url":1058,"identifiers":1059},"Risbud MV, Schaer TP, Shapiro IM (2010) Toward an understanding of the role of notochordal cells in the adult intervertebral disc: from discord to accord. Dev Dyn 239:2141–2148. doi:10.1002\u002Fdvdy.22350","https:\u002F\u002Fdoi.org\u002F10.1002\u002Fdvdy.22350",{"mag":1060,"pmc":1061,"openalex":1062,"pm":1063,"doi":1064},"2027857819","3634351","W2027857819","20568241","10.1002\u002Fdvdy.22350",{"id":1066,"text":1067,"url":1068,"identifiers":1069},"3d9434b5-6491-45fe-89d3-9f45f9d061a9","Rufai A, Benjamin M, Ralphs JR (1995) The development of fibrocartilage in the rat intervertebral disc. Anat Embryol (Berl) 192(1):53–62","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002FBF00186991",{"doi":1070},"10.1007\u002FBF00186991",{"id":18,"text":1072,"url":18,"identifiers":1073},"Sakai D, Nakai T, Mochida J, Alini M, Grad S (2009) Differential phenotype of intervertebral disc cells: microarray and immunohistochemical analysis of canine nucleus pulposus and anulus fibrosus. Spine 34(14):1448–1456. doi:10.1097\u002FBRS.0b013e3181a55705",{"doi":1074},"10.1097\u002FBRS.0b013e3181a55705",{"id":18,"text":1076,"url":1077,"identifiers":1078},"Sarkar D, Shields B, Davies ML, Müller J, Wakeman JA (2011) BRACHYURY confers cancer stem cell characteristics on colorectal cancer cells. Int J Cancer. doi:10.1002\u002Fijc.26029","https:\u002F\u002Fdoi.org\u002F10.1002\u002Fijc.26029",{"mag":1079,"openalex":1080,"pm":1081,"doi":1082},"2133580699","W2133580699","21365650","10.1002\u002Fijc.26029",{"id":310,"text":1084,"url":312,"identifiers":1085},"Schmittgen TD, Zakrajsek BA (2000) Effect of experimental treatment on housekeeping gene expression: validation by real-time, quantitative RT-PCR. J Biochem Biophys Methods 46(1–2):69–81",{"doi":314},{"id":1087,"text":1088,"url":1089,"identifiers":1090},"a0a2ffc7-756f-461e-bd90-5f4f734d0adc","Shapiro IM, Risbud MV (2010) Transcriptional profiling of the nucleus pulposus: say yes to notochord. Arthritis Res Ther 12(3):117. doi:10.1186\u002Far3003","https:\u002F\u002Farthritis-research.biomedcentral.com\u002Farticles\u002F10.1186\u002Far3003",{"doi":1091},"10.1186\u002Far3003",{"id":18,"text":1093,"url":1094,"identifiers":1095},"Vujovic S, Henderson S, Presneau N, Odell E, Jacques TS, Tirabosco R, Boshoff C, Flanagan AM (2006) Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas. J Pathol 209(2):157–165. doi:10.1002\u002Fpath.1969","https:\u002F\u002Fdoi.org\u002F10.1002\u002Fpath.1969",{"mag":1096,"openalex":1097,"pm":1098,"doi":1099},"2077480850","W2077480850","16538613","10.1002\u002Fpath.1969",{"id":310,"text":1101,"url":312,"identifiers":1102},"Walmsley R (1953) The development and growth of the intervertebral disc. Edinburgh Med J 60:341–365",{"doi":314},{"id":1104,"text":1105,"url":1106,"identifiers":1107},"f74e9d2d-6e45-4fc2-a9e9-dd224cc883dc","Weiler C, Nerlich AG, Schaaf R, Bachmeier BE, Wuertz K, Boos N (2010) Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc. Eur Spine J. doi:10.1007\u002Fs00586-010-1392-z","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00586-010-1392-z",{"doi":1108},"10.1007\u002Fs00586-010-1392-z",{"id":1110,"createTime":1111,"updateTime":1112,"relativeEntities":1113,"slug":1114,"properties":1115,"entityType":215,"verifyStatus":216,"verifyTime":1126,"verifyNote":218,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1127,"fullTextUrl":18,"authors":1128,"publicationType":251,"publisherRelationship":1240,"citationCount":19,"citationInfo":1291,"publishDate":1294,"publishYear":1292,"citationAnalyzeStatus":879,"lastCitationAnalyze":1112,"indexDatabases":1295,"openAccess":18,"references":18,"isForceReanalyzing":327},"3cec355f-6910-4f2e-8107-07fb401227c8","2024-01-09T05:17:32.506+00:00","2026-07-27T19:59:14.843+00:00",[],"Correlation-between-pyramidal-signs-and-the-severity-of-cervical-myelopathy",{"abstract":1116,"title":1118,"gsPaper":1120,"references":1122,"doi":1124},{"EN":1117},"A retrospective study was performed to determine the sensitivities of the pyramidal signs in patients with cervical myelopathy, focusing on those with increased signal intensity (ISI) in T2-weighted magnetic resonance imaging (MRI). The relationship between prevalence of the pyramidal signs and the severity of myelopathy was investigated. We reviewed the records of 275 patients with cervical myelopathy who underwent surgery. Of these, 143 patients were excluded from this study due to comorbidities that might complicate neurological findings. The MR images of the remaining 132 patients were evaluated in a blinded fashion. The neurological findings of 120 patients with ISI (90 men and 30 women; mean age 61 years) were reviewed for hyperreflexia (patellar tendon reflex), ankle clonus, Hoffmann reflex, and Babinski sign. To assess the severity of myelopathy, the motor function scores of the upper and lower extremities for cervical myelopathy set by the Japanese Orthopaedic Association (m-JOA score) were used. The most prevalent signs were hyperreflexia (94%), Hoffmann reflex (81%), Babinski sign (53%), and ankle clonus (35%). Babinski sign (P \u003C 0.001), ankle clonus, and Hoffmann reflex showed significant association with the lower m-JOA score. Conversely, no association was found with the upper m-JOA score. In patients with cervical myelopathy, hyperreflexia showed the highest sensitivity followed by Hoffmann reflex, Babinski sign, and ankle clonus. The prevalence of the pyramidal signs correlated with increasing severity of myelopathy. Considering their low sensitivity in patients with mild disability, the pyramidal signs may have limited utility in early diagnosis of cervical myelopathy.",{"EN":1119},"Correlation between pyramidal signs and the severity of cervical myelopathy",{"VOID":1121},"[\"288635462162344510\"]",{"VOID":1123},"Bednarik J, Kadanka Z, Vohanka S, Novotny O, Surelova D, Filipovicova D, Prokes B (1998) The value of somatosensory and motor evoked potentials in pre-clinical spondylotic cervical cord compression. Eur Spine J 7:493–500\nChiles BW III, Leonard MA, Choudhri HF, Cooper PR (1999) Cervical spondylotic myelopathy: patterns of neurological deficit and recovery after anterior cervical decompression. Neurosurgery 44:762–769 (discussion 769–770)\nDillin WH, Watkins RG (1992) Clinical syndromes in cervical myelopathy. In: Rothman RH, Simeone FA (eds) The spine, 3rd edn. W.B. Saunders, Philadelphia, pp 560–570\nDvorak J, Sutter M, Herdmann J (2003) Cervical myelopathy: clinical and neurophysiological evaluation. Eur Spine J 12(suppl 2):S181–187\nEmery SE (2001) Cervical spondylotic myelopathy: diagnosis and treatment. J Am Acad Orthop Surg 9:376–388\nGlaser JA, Cure JK, Bailey KL, Morrow DL (2001) Cervical spinal cord compression and the Hoffmann sign. Iowa Orthop J 21:49–52\nHerdmann J, Linzbach M, Kranz M, Dvorak J, Bock WJ (1994) The European Myelopathy Score. In: Bauer BL, Brock M, Klinger M (eds) Advances in neurosurgery. Springer, Berlin, pp 266–268\nHirabayashi K, Miyakawa J, Satomi K, Maruyama T, Wakano K (1981) Operative results and postoperative progression of ossification among patients with ossification of cervical posterior longitudinal ligament. Spine (Phila Pa 1976) 6:354–364\nHolly LT, Dong Y, Albistegui-DuBois R, Marehbian J, Dobkin B (2007) Cortical reorganization in patients with cervical spondylotic myelopathy. J Neurosurg Spine 6:544–551\nHolly LT, Moftakhar P, Khoo LT, Shamie AN, Wang JC (2008) Surgical outcomes of elderly patients with cervical spondylotic myelopathy. Surg Neurol 69:233–240\nHouten JK, Noce LA (2008) Clinical correlations of cervical myelopathy and the Hoffmann sign. J Neurosurg Spine 9:237–242\nIwasaki M, Okuda S, Miyauchi A, Sakaura H, Mukai Y, Yonenobu K, Yoshikawa H (2007) Surgical strategy for cervical myelopathy due to ossification of the posterior longitudinal ligament: part 1: clinical results and limitations of laminoplasty. Spine (Phila Pa 1976) 32:647–653\nKamata M, Satomi K (1997) Classification of cervical myelopathy (in Japanese). MB Orthop 10:1–6\nLunsford LD, Bissonette DJ, Zorub DS (1980) Anterior surgery for cervical disc disease. Part 2: treatment of cervical spondylotic myelopathy in 32 cases. J Neurosurg 53:12–19\nMikulis DJ, Jurkiewicz MT, McIlroy WE, Staines WR, Rickards L, Kalsi-Ryan S, Crawley AP, Fehlings MG, Verrier MC (2002) Adaptation in the motor cortex following cervical spinal cord injury. Neurology 58:794–801\nMorio Y, Teshima R, Nagashima H, Nawata K, Yamasaki D, Nanjo Y (2001) Correlation between operative outcomes of cervical compression myelopathy and MRI of the spinal cord. Spine (Phila Pa 1976) 26:1238–1245\nRhee JM, Heflin JA, Hamasaki T, Freedman B (2009) Prevalence of physical signs in cervical myelopathy: a prospective, controlled study. Spine (Phila Pa 1976) 34:890–895\nSakaura H, Hosono N, Mukai Y, Oshima K, Iwasaki M, Yoshikawa H (2008) Preservation of the nuchal ligament plays an important role in preventing unfavorable radiologic changes after laminoplasty. J Spinal Disord Tech 21:338–343\nSeichi A, Takeshita K, Kawaguchi H, Nakajima S, Akune T, Nakamura K (2004) Postoperative expansion of intramedullary high-intensity areas on t2-weighted magnetic resonance imaging after cervical laminoplasty. Spine (Phila Pa 1976) 29:1478–1482 (discussion 1482)\nSuri A, Chabbra RP, Mehta VS, Gaikwad S, Pandey RM (2003) Effect of intramedullary signal changes on the surgical outcome of patients with cervical spondylotic myelopathy. Spine J 3:33–45\nTsuji T, Asazuma T, Masuoka K, Yasuoka H, Motosuneya T, Sakai T, Nemoto K (2007) Retrospective cohort study between selective and standard c3–7 laminoplasty. Minimum 2-year follow-up study. Eur Spine J 16:2072–2077\nVan Gijn J, Bonke B (1977) Interpretation of plantar reflexes: biasing effect of other signs and symptoms. J Neurol Neurosurg Psychiatry 40:787–789\nYonenobu K, Abumi K, Nagata K, Taketomi E, Ueyama K (2001) Interobserver and intraobserver reliability of the Japanese Orthopaedic Association scoring system for evaluation of cervical compression myelopathy. Spine (Phila Pa 1976) 26:1890–1894 (discussion 1895)\nYukawa Y, Kato F, Ito K, Horie Y, Hida T, Machino M, Ito ZY, Matsuyama Y (2008) Postoperative changes in spinal cord signal intensity in patients with cervical compression myelopathy: comparison between preoperative and postoperative magnetic resonance images. J Neurosurg Spine 8:524–528",{"VOID":1125},"10.1007\u002Fs00586-010-1364-3","2024-05-16T13:21:45.755+00:00","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00586-010-1364-3",[1129,1146,1161,1174,1187,1200,1213,1226],{"id":1130,"sortIndex":19,"researcher":18,"roles":1131,"affiliations":1132,"properties":1141,"displayName":1143,"givenName":18,"familyName":18},"b29b26d2-b0f7-490c-96e1-74c7957cbe0b",[224],[1133],{"id":1134,"sortIndex":19,"affiliation":1135,"properties":18},"168ab2f3-5ccb-4196-9a93-75d96c6b7676",{"id":1134,"createTime":18,"updateTime":18,"relativeEntities":1136,"slug":18,"properties":1137,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1140,"statistic":18},[],{"title":1138},{"VI":1139},"Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan",[],{"title":1142,"gsAuthor":1144},{"VI":1143},"Hirotaka Chikuda",{"VOID":1145},"[\"3jEiBBkAAAAJ\"]",{"id":1147,"sortIndex":239,"researcher":18,"roles":1148,"affiliations":1149,"properties":1158,"displayName":1160,"givenName":18,"familyName":18},"577629a0-7da5-4279-9227-31cbfba0521c",[224],[1150],{"id":1151,"sortIndex":19,"affiliation":1152,"properties":18},"a6ddd3d7-2076-40a5-a354-4ccf45dfefd8",{"id":1151,"createTime":18,"updateTime":18,"relativeEntities":1153,"slug":18,"properties":1154,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1157,"statistic":18},[],{"title":1155},{"VI":1156},"Department of Orthopaedics, Jichi Medical University, Tochigi, Japan",[],{"title":1159},{"VI":1160},"Atsushi 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recent years, non-fusion implants to stabilise the lumbar spine have become more and more popular. However, little is known on the load bearing of such dynamic stabilisation systems. In order to investigate the load bearing of discs bridged with rigid and dynamic stabilisation systems, six lumbar cadaver spines were mounted in a spine tester and loaded with pure moments in the three main motion planes. Four different states of the specimens were studied: intact, destabilised, stabilisation with a Dynesys® and stabilisation with an internal fixator. Intradiscal pressure (IDP) measurements were used to assess the load bearing of the bridged disc. In the neutral unloaded position, there were small but not significant differences in disc pressure for the four states of the treated disc (P>0.05). Concerning the disc pressure during the course of loading, both the Dynesys® and internal fixator did significantly reduce the pressure change from neutral to extension in comparison to the intact state (−0.05, −0.04 and +0.24 MPa, respectively) (P\u003C0.05). Compared to the intact state, there was no significant pressure change from neutral to flexion (0.14, 0.15 and 0.18 MPa, respectively) (P>0.05). The devices apparently eliminated the pressure change from neutral to lateral bending (Dynesys 0.01 MPa, Fixator 0.01 MPa and intact 0.24 MPa), but due to large variations in the intact and defect states the differences were not significant (P>0.05). In axial rotation, the pressure change for the internal fixator was reduced compared to the intact state; however, the change was only significant in left axial rotation (P\u003C0.05). The Dynesys® showed no significant differences (P>0.05) in axial rotation. No changes in IDP were seen in the adjacent discs for either the Dynesys or the internal fixator. Our results showed that the IDPs for both devices were similar, but altered compared to the intact disc.",{"EN":1306},"Influence of a dynamic stabilisation system on load bearing of a bridged disc: an in vitro study of intradiscal pressure",{"VOID":1308},"[]",{"VOID":1310},"Abe E, Nickel T, Buttermann GR, Lewis JL, Transfeldt EE (1998) Lumbar intradiscal pressure after posterolateral fusion and pedicle screw fixation. Tohoku J Exp Med 186(4):243–253\nAdams MA, McMillan DW, Green TP, Dolan P (1996) Sustained loading generates stress concentrations in lumbar intervertebral discs. Spine 21(4):434–438\nAdams MA, McNally DS, Dolan P (1996) ‘Stress’ distributions inside intervertebral discs. The effects of age and degeneration. J Bone Joint Surg Br 78(6):965–972\nChow DH, Luk KD, Evans JH, Leong JC (1996) Effects of short anterior lumbar interbody fusion on biomechanics of neighboring unfused segments. Spine 21(5):549–555\nCunningham BW, Kotani Y, McNulty PS, Cappuccino A, McAfee PC (1997) The effect of spinal destabilization and instrumentation on lumbar intradiscal pressure: an in vitro biomechanical analysis. Spine 22(22):2655–2663\nEsses SI, Sachs BL, Dreyzin V (1993) Complications associated with the technique of pedicle screw fixation. A selected survey of ABS members. Spine 18(15):2231–2238 (discussion 2238–2239)\nFreudiger S, Dubois G, Lorrain M (1999) Dynamic neutralisation of the lumbar spine confirmed on a new lumbar spine simulator in vitro. Arch Orthop Trauma Surg 119(3–4):127–132\nGrevitt MP, Gardner AD, Spilsbury J, Shackleford IM, Baskerville R, Pursell LM et al (1995) The Graf stabilisation system: early results in 50 patients. Eur Spine J 4(3):169–175 (discussion 135)\nKorge A, Nydegger T, Polard JL, Mayer HM, Husson JL (2002) A spiral implant as nucleus prosthesis in the lumbar spine. Eur Spine J 11(Suppl 2):S149–S153\nKumar MN, Baklanov A, Chopin D (2001) Correlation between sagittal plane changes and adjacent segment degeneration following lumbar spine fusion. Eur Spine J 10(4):314–319\nLee CK (1988) Accelerated degeneration of the segment adjacent to a lumbar fusion. Spine 13(3):375–377\nLehmann TR, Spratt KF, Tozzi JE, Weinstein JN, Reinarz SJ, el-Khoury GY et al (1987) Long-term follow-up of lower lumbar fusion patients. Spine 12(2):97–104\nLink HD (2002) History, design and biomechanics of the LINK SB Charite artificial disc. Eur Spine J 11(Suppl 2):S98–S105\nMayer HM, Wiechert K, Korge A, Qose I (2002) Minimally invasive total disc replacement: surgical technique and preliminary clinical results. Eur Spine J 11(Suppl 2):S124–S130\nMcAfee PC, Weiland DJ, Carlow JJ (1991) Survivorship analysis of pedicle spinal instrumentation. Spine 16(Suppl 8):S422–S427\nMcNally DS, Adams MA (1992) Internal intervertebral disc mechanics as revealed by stress profilometry. Spine 17(1):66–73\nMimura M, Panjabi MM, Oxland TR, Crisco JJ, Yamamoto I, Vasavada A (1994) Disc degeneration affects the multidirectional flexibility of the lumbar spine. Spine 19(12):1371–1380\nMolz FJ, Partin JI, Kirkpatrick JS (2003) The acute effects of posterior fusion instrumentation on kinematics and intradiscal pressure of the human lumbar spine. J Spinal Disord Tech 16(2):171–179\nNachemson A (1966) The load on lumbar disks in different positions of the body. Clin Orthop 45:107–122\nNachemson AL (1981) Disc pressure measurements. Spine 6(1):93–97\nOkuyama K, Abe E, Suzuki T, Tamura Y, Chiba M, Sato K (1999) Posterior lumbar interbody fusion: a retrospective study of complications after facet joint excision and pedicle screw fixation in 148 cases. Acta Orthop Scand 70(4):329–334\nPenta M, Sandhu A, Fraser RD (1995) Magnetic resonance imaging assessment of disc degeneration 10 years after anterior lumbar interbody fusion. Spine 20(6):743–747\nPollintine P, Przybyla AS, Dolan P, Adams MA (2004) Neural arch load-bearing in old and degenerated spines. J Biomech 37(2):197–204\nQuint U, Wilke HJ, Loer F, Claes L (1998) Possibilities for static and dynamic stabilization of the spine in lesions of the anterior and posterior ligament complex. Unfallchirurg 101(9):684–690\nRohlmann A, Neller S, Bergmann G, Graichen F, Claes L, Wilke HJ (2001) Effect of an internal fixator and a bone graft on intersegmental spinal motion and intradiscal pressure in the adjacent regions. Eur Spine J 10(4):301–308\nRohlmann A, Neller S, Claes L, Bergmann G, Wilke HJ (2001) Influence of a follower load on intradiscal pressure and intersegmental rotation of the lumbar spine. Spine 26(24):E557–E561\nSato K, Kikuchi S, Yonezawa T (1999) In vivo intradiscal pressure measurement in healthy individuals and in patients with ongoing back problems. Spine 24(23):2468–2474\nSchlegel JD, Smith JA, Schleusener RL (1996) Lumbar motion segment pathology adjacent to thoracolumbar, lumbar, and lumbosacral fusions. Spine 21(8):970–981\nSchmoelz W, Huber JF, Nydegger T, Claes L, Wilke HJ (2003) Dynamic stabilization of the lumbar spine and its effects on adjacent segments: an in vitro experiment. J Spinal Disord Tech 16(4):418–423\nSeitsalo S, Schlenzka D, Poussa M, Osterman K (1997) Disc degeneration in young patients with isthmic spondylolisthesis treated operatively or conservatively: a long-term follow-up. Eur Spine J 6(6):393–397\nStoll TM, Dubois G, Schwarzenbach O (2002) The dynamic neutralization system for the spine: a multi-center study of a novel non-fusion system. Eur Spine J 11(Suppl 2):S170–S178\nSwanson KE, Lindsey DP, Hsu KY, Zucherman JF, Yerby SA (2003) The effects of an interspinous implant on intervertebral disc pressures. Spine 28(1):26–32\nTrommsdorff U, Zurbruegg D, Schneider W (2004) Biostability of poly(ethylene-terephthalate) cords used in a spinal implant system. In: Seventh World Biomaterials Congress, Sydney, Australia, p 1364\nTrommsdorff U, Zurbruegg D, Stoll TM (2004) In-vivo stability of polycarbonate-urethane with and without contact to an abscess. In: Seventh World Biomaterials Congress, Sydney, Australia, p 337\nWeinhoffer SL, Guyer RD, Herbert M, Griffith SL (1995) Intradiscal pressure measurements above an instrumented fusion. A cadaveric study. Spine 20(5):526–531\nWilke HJ, Claes L, Schmitt H, Wolf S (1994) A universal spine tester for in vitro experiments with muscle force simulation. Eur Spine J 3(2):91–97\nWilke HJ, Kavanagh S, Neller S, Haid C, Claes LE (2001) Effect of a prosthetic disc nucleus on the mobility and disc height of the L4–5 intervertebral disc postnucleotomy. J Neurosurg 95(Suppl 2):208–214\nWilke HJ, Neef P, Caimi M, Hoogland T, Claes LE (1999) New in vivo measurements of pressures in the intervertebral disc in daily life. Spine 24(8):755–762\nWilke HJ, Rohlmann A, Neller S, Schultheiss M, Bergmann G, Graichen F et al (2001) Is it possible to simulate physiologic loading conditions by applying pure moments? A comparison of in vivo and in vitro load components in an internal fixator. Spine 26(6):636–642\nWilke HJ, Wenger K, Claes L (1998) Testing criteria for spinal implants: recommendations for the standardization of in vitro stability testing of spinal implants. Eur Spine J 7(2):148–154\nWilke HJ, Wolf S, Claes LE, Arand M, Wiesend A (1996) Influence of varying muscle forces on lumbar intradiscal pressure: an in vitro study. 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Based on literature review and on personal experience, surgical site infection, cerebrospinal fluid leakage, tumor recurrence and hardware failures are some of the possible causes of surgical revision in this set of patients. The aim of this study is to evaluate the most frequent complications that can lead to revision in spine tumor patients, to provide suggestions on how to prevent these events and to offer reasonable strategies to properly plan and perform a revision surgery. These slides can be retrieved under Electronic Supplementary Material. \n                  \n                    \n                      \n                    \n                  \n                ",{"EN":1462},"Revision surgery for tumors of the thoracic and lumbar spine: causes, prevention, and treatment strategy",{"VOID":1464},"[\"11904589125742322172\"]",{"VOID":1466},"Colman MW, Karim SM, Lozano-Calderon SA, Pedlow FX, Raskin KA, Hornicek FJ et al (2015) Quality of life after en bloc resection of tumors in the mobile spine. Spine J 15(8):1728–1737\nFisher CG, Saravanja DD, Dvorak MF, Rampersaud YR, Clarkson PW, Hurlbert J et al (2011) Surgical management of primary bone tumors of the spine. Spine 36(10):830–836\nGösling T, Pichlmaier MA, Länger F, Krettek C, Hüfner T (2012) Two-stage multilevel en bloc spondylectomy with resection and replacement of the aorta. Eur Spine J 22(S3):363–368\nMurakami H, Tomita K, Kawahara N, Oda M, Yahata T, Yamaguchi T (2006) Complete segmental resection of the spine, including the spinal cord, for telangiectatic osteosarcoma: a report of 2 cases. Spine (Phila Pa 1976) 31(4):E117–E122\nLuzzati AD, Shah S, Gagliano F, Perrucchini G, Scotto G, Alloisio M (2014) Multilevel en bloc spondylectomy for tumors of the thoracic and lumbar spine is challenging but rewarding. Clin Orthop Relat Res 473(3):858–867\nBoriani S, Gasbarrini A, Bandiera S, Ghermandi R, Lador R (2016) Predictors for surgical complications of en bloc resections in the spine: review of 220 cases treated by the same team. Eur Spine J 25(12):3932–3941\nPaulino Pereira NR, Ogink PT, Groot OQ, Ferrone ML, Hornicek FJ, van Dijk CN et al (2019) Complications and reoperations after surgery for 647 patients with spine metastatic disease. Spine J 19(1):144–156\nAlamand VK, Robinson MM, Kneisl JS, Spector LT, Patt JC (2018) Survival outcomes and factors associated with revision surgery for metastatic disease of the spine. J Oncol 25(2018):6140381\nZoccali C, Scotto G, Cannavò L, Baldi J, Scaffidi-Argentina U, Luzzati A (2019) En bloc spondylectomy in patients older than 60 years: indications, results and complications in a series of 37 patients. Eur Spine J 28(6):1512–1519\nBoriani S, Gasbarrini A, Bandiera S, Ghermandi R, Lador R (2017) En bloc resections in the spine: the experience of 220 patients during 25 years. World Neurosurg 98:217–229\nGraulich T, Krettek C, Müller CW (2019) Revision strategy and follow-up for implant failure in a case of combined anterior and posterior reconstruction after three-level en bloc vertebral body replacement and replacement of the aorta for chondrosarcoma of the thoracic spine. Eur Spine J 28(Suppl 2):13–17\nSomasundaram A, Wicks RT, Lata AL, Qasem SA, Hsu W (2015) En bloc spondylectomy for primary malignant fibrous histiocytoma of the thoracic spine with aortic involvement: case report. J Neurosurg Spine 22(4):399–405\nPrabhu VC, Bilsky MH, Jambhekar K, Panageas KS, Boland PJ, Lis E et al (2003) Results of preoperative embolization for metastatic spinal neoplasms. J Neurosurg 98(2 Suppl):156–164\nZanirato A, Damilano M, Formica M, Piazzolla A, Lovi A, Villafañe JH (2018) Complications in adult spine deformity surgery: a systematic review of the recent literature with reporting of aggregated incidences. Eur Spine J 27(9):2272–2284\nSchulz N, Kolenda H, Thiel A, Vestring T, Schulte M (2010) Subarachnoid pleural fistula and subsequent pneumocephalus as complication of vertebral body replacement of the thoracic spine. Unfallchirurg 113(11):951–956\nNyunoya T, Gross T, Rooney C, Mendoza S, Kline J (2003) Massive pleural transudate following a vertebral fusion in a 49-year-old woman. Chest 123(4):1280–1283\nHuggins JT, Sahn SA (2003) Duro-pleural fistula diagnosed by beta2-transferrin. Respiration 70(4):423–425\nPapavero L, Engler N, Kothe R (2015) Incidental durotomy in spine surgery: first aid in ten steps. Eur Spine J 24(9):2077–2084. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00586-015-3837-x\nValla FV (2007) Subarachnoid-pleural fistula in an infant treated with mechanical positive-pressure ventilation. Pediatr Crit Care Med PAP(4):386–388\nHentschel SJ, Rhines LD, Wong FC, Gokaslan ZL, McCutcheon IE (2004) Subarachnoid-pleural fistula after resection of thoracic tumors. J Neurosurg 100(4 Suppl Spine):332–336\nHeller JG, Kim HS, Carlson GW (2001) Subarachnoid-pleural fistulae—management with a transdiaphragmatic pedicled greater omental flap. Spine (Phila Pa 1976) 26(16):1809–1813\nBoriani S, Gasbarrini A (2005) Point of view. Spine 30:2227–2229\nEnneking WF, Spanier SS, Goodmann M (1980) A system for surgical staging of musculoskeletal sarcoma. Clin Orthop 153:106–120\nLuzzati A et al (2017) Salvage revision surgery after inappropriate approach for primary spine tumors: long term follow-up in 56 cases. World Neurosurg 98:329–333\nWalcott BP et al (2012) Chordoma: current concepts, management, and future directions. Lancet Oncol 13(2):e69–e76\nStacchiotti S, Sommer J (2015) On behalf of a chordoma global consensus group. Building a global consensus approach to chordoma: a position paper from the medical and patient community. Lancet Oncol 16(2):e71–e83\nBoriani S, Saravanja D, Yamada Y, Varga PP, Biagini R, Fisher CG (2009) Challenges of local recurrence and cure in low grade malignant tumors of the spine. Spine 34(22S):548–557\nAilon T, Torabi R, Fisher CG, Rhines LD, Clarke MJ, Bettegowda C et al (2016) Management of locally recurrent chordoma of the mobile spine and sacrum. Spine 41:S193–S198\nShankar GM, Clarke MJ, Ailon T, Rhines LD, Patel SR, Sahgal A, Laufer I, Chou D, Bilsky MH, Sciubba DM, Fehlings MG, Fisher CG, Gokaslan ZL, Shin JHJ (2017) The role of revision surgery and adjuvant therapy following subtotal resection of osteosarcoma of the spine: a systematic review with meta-analysis. Neurosurg Spine 27(1):97–104. https:\u002F\u002Fdoi.org\u002F10.3171\u002F2016.12.SPINE16995\nPennicooke B, Laufer I, Sahgal A, Varga PP, Gokaslan ZL, Bilsky MH, Yamada YY (2016) Safety and local control of radiation therapy for chordoma of the spine and sacrum. Spine 41:S186–S192\nVerburg JM, Seco J (2013) Dosimetric accuracy of proton therapy for chordoma patients with titanium implants. Med Phys 40(7):071727\nBoriani S, Tedesco G, Ming L, Ghermandi R, Amichetti M, Fossati P et al (2018) Carbon-fiber-reinforced PEEK fixation system in the treatment of spine tumors: a preliminary report. Eur Spine J 27(4):874–881\nLaufer I, Iorgulescu JB, Chapman T, Lis E, Shi W, Zhang Z et al (2013) Local disease control for spinal metastases following “separation surgery” and adjuvant hypofractionated or high-dose single-fraction stereotactic radiosurgery: outcome analysis in 186 patients. J Neurosurg Spine 18:207–214\nMastella E, Molinelli S, Magro G, Mirandola A, Russo S, Vai A et al (2018) Dosimetric characterization of carbon fiber stabilization devices for post-operative particle therapy. Physica Med 44:18–25\nNevelsky A, Borzov E, Daniel S, Bar-Deroma R (2017) Perturbation effects of the carbon fiber-PEEK screws on radiotherapy dose distribution. JAppl Clin Med Phys 18(2):62–68\nBoriani S, Weinstein JN, Biagini R (1997) Primary bone tumors of the spine. Terminology and surgical staging. Spine 22:1036–1044\nFisher CG, Keynan O, Boyd MC, Dvorak MF (2005) The surgical management of primary tumors of the spine. Spine 30(16):1899–1908\nMian TA, van Putten MC Jr, Kramer DC, Jacob RF, Boyer AL (1987) Backscatter radiation at bone–titanium interface from high energy X and gamma rays. Int J Radiat Oncol Biol Phys 13:1943–1947\nXin-ye N et al (2012) The prospect of carbon fiber implants in radiotherapy. J Appl Clin Med Phys 13(4):3821\nBoriani S, Biagini R, Bandiera S, Gasbarrini A, De Iure F (2002) Reconstruction of the anterior column of the thoracic and lumbar spine with a carbon fiber stackable cage system. Orthopedics 25(1):37–42\nBettegowda C, Yip S, Jiang B, Wang WL, Clarke MJ, Lazary A, Gambarotti M, Zhang M, Sciubba DM, Wolinsky JP, Goodwin CR, McCarthy E, Germscheid NM, Sahgal A, Gokaslan ZL, Boriani S, Varga PP, Fisher CG, Rhines LD (2019) Prognostic significance of hTERT (human telomerase reverse transcriptase) promoter region mutations C228T and C250T for overall survival in spinal chordomas. Neuro Oncol pii:noz066. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fneuonc\u002Fnoz066\nDepreitere B, Ricciardi F, Arts M, Balabaud L, Buchowski JM, Bunger C, Chung CK, Coppes MH, Fehlings MG, Kawahara N, Lee CS, Leung Y, Martin-Benlloch JA, Massicotte EM, Mazel C, Meyer B, Oner FC, Peul W, Quraishi N, Tokuhashi Y, Tomita K, Ulbricht C, Verlaan JJ, Wang M, Crockard HA, Choi D (2018) Loss of local tumor control after index surgery for spinal metastases: a prospective cohort study. World Neurosurg 117:e8–e16. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.wneu.2018.04.170\nCecchinato R, Boriani S (2018) Spondylolisthesis and tumors: a treatment algorithm. Eur Spine J 27(Suppl 2):206–212\nObeid I, Berjano P, Lamartina C, Chopin D, Boissière L, Bourghli A (2019) Classification of coronal imbalance in adult scoliosis and spine deformity: a treatment-oriented guideline. Eur Spine J 28(1):94–113\nCecchinato R, Redaelli A, Martini C, Morselli C, Villafañe JH, Lamartina C, Berjano P (2017) Long fusions to S1 with or without pelvic fixation can induce relevant acute variations in pelvic incidence: a retrospective cohort study of adult spine deformity surgery. Eur Spine J 26(Suppl 4):436–441\nLaouissat F, Sebaaly A, Gehrchen M, Roussouly P (2018) Classification of normal sagittal spine alignment: refounding the Roussouly classification. Eur Spine J 27(8):2002–2011\nBoriani S (2018) En bloc resection in the spine: a procedure of surgical oncology. J Spine Surg 4(3):668–676\nBerjano P, Xu M, Damilano M, Scholl T, Lamartina C, Jekir M, Galbusera F (2019) Supplementary delta-rod configurations provide superior stiffness and reduced rod stress compared to traditional multiple-rod configurations after pedicle subtraction osteotomy: a finite element study. Eur Spine J. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00586-019-06012-2\nBarzilai O, Versteeg AL, Sahgal A, Rhines LD, Bilsky MH, Sciubba DM, Schuster JM, Weber MH, Pal Varga P, Boriani S, Bettegowda C, Fehlings MG, Yamada Y, Clarke MJ, Arnold PM, Gokaslan ZL, Fisher CG, Laufer I, The Ao Spine Knowledge Forum Tumor (2019) Survival, local control, and health-related quality of life in patients with oligometastatic and polymetastatic spinal tumors: A multicenter, international study. Cancer 125(5):770–778. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fcncr.31870",{"VOID":1468},"10.1007\u002Fs00586-019-06276-8","2024-06-25T00:00:43.974+00:00","http:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs00586-019-06276-8",[1472,1489,1504,1519],{"id":1473,"sortIndex":19,"researcher":18,"roles":1474,"affiliations":1475,"properties":1484,"displayName":1486,"givenName":18,"familyName":18},"e12bd272-5431-47d1-bdce-ffcc20863eb8",[224],[1476],{"id":1477,"sortIndex":19,"affiliation":1478,"properties":18},"08d9f4af-a99a-41d6-8ae1-831a52ee6648",{"id":1477,"createTime":18,"updateTime":18,"relativeEntities":1479,"slug":18,"properties":1480,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1483,"statistic":18},[],{"title":1481},{"VI":1482},"GSpine4, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy",[],{"title":1485,"gsAuthor":1487},{"VI":1486},"Pedro 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Videoassisted thoracoscopic surgery (VATS) allows the surgeon to perform an anterior thoracoscopic spine release for spinal deformities. It is an alternative to open thoracotomy. Several years after its introduction the present author gives an update on the indications, surgical techniques, results, and complications of this new technology. A meta-analysis of previously published papers is organized in tables in an attempt to answer all the questions and controversies that this technique has aroused. A series of ten selected articles were available for review, comprising a total of 151 procedures. No study had any long-term follow-up. Most series were pediatric and involved a variety of etiologies (mostly neuromuscular, adolescent idiopathic scoliosis, and Scheuermann’s kyphosis). The surgical technique was for most authors a convex side approach in the lateral decubitus through four or more ports in the anterior or midaxillary line. Single lung ventilation was used in most cases. Posterior surgery was carried out the same day in most cases. The total number of discs excised varied between 4 and 7, but the quality of disc excision was rarely reported. Most authors carried out a spine fusion at the time of the disc release. The total VATS procedure lasted between 2 h 30 min and 4 h, depending on the series and the surgeon’s previous experience. In most series curves were in the range of 55°–80°, with an average of 65°. The percentage of Cobb angle correction was 55%–63% after VATS and posterior spine fusion. For kyphotic deformities only one series had significant numbers to allow conclusions to be drawn. The mean preoperative Cobb angle was 78° and postoperatively the kyphosis was corrected to 44°. Length of hospital stay was quite similar in most series and was around 9 days. The cost of the VATS procedure was studied in one series and was found to be 28% more expensive than thoracotomy. The total complications reported were 18%; most were pulmonary complications with prolonged ventilatory support in patients with neuromuscular pathologies. The VATS procedure has been used with success in most series for pediatric curves (average Cobb angle of 65° or kyphosis of 75°). No report of the surgical outcome (balance, rate of fusion, rib hump correction, cosmetic correction, pain, and patient satisfaction) was available for any series. Further prospective study including these parameters will be required to determine the real benefit of such procedures to the patient, bearing in mind that the correction of spinal deformities is the result of the surgeon’s experience, skill, and the available technology.",{"EN":1599},"Anterior thoracoscopic spine release in deformity surgery: a meta-analysis and review",{"VOID":1601},"[\"12638865154779024157\"]",{"VOID":1603},"10.1007\u002Fs005860000186","2024-08-31T00:07:28.538+00:00","http:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs005860000186",[1607],{"id":1608,"sortIndex":19,"researcher":18,"roles":1609,"affiliations":1610,"properties":1619,"displayName":1621,"givenName":18,"familyName":18},"904b671a-f775-4d71-a2c8-a1deca600b27",[224],[1611],{"id":1612,"sortIndex":19,"affiliation":1613,"properties":18},"9f2623c7-ea1f-481b-ae9f-af7d4aff5c95",{"id":1612,"createTime":18,"updateTime":18,"relativeEntities":1614,"slug":18,"properties":1615,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1618,"statistic":18},[],{"title":1616},{"VI":1617},"McGill University,  Division of Orthopedic Surgery,  Montreal Children’s Hospital,  2300 Tupper Street, Suite C-1112,  Montreal, Quebec, Canada, H3H 1P3  Tel.: +1-514-934-4468  Fax: +1-514-934-4341, , CA",[],{"title":1620},{"VI":1621},"V. 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The objective of this study was to identify the intraoperative difficulties and postoperative complications associated with revision anterior lumbar spine procedures in a single institution. This is a retrospective review of 25 consecutive anterior revision lumbar surgeries in 22 patients (7 men and 15 women) operated on between 1998 and 2011. Patients with trauma or malignancies were excluded. The mean age of the patients at the time of revision surgery was 56 years (range 20–80 years). The complications were analyzed depending on the operative level and the time between the index surgery and the revision. Six major complications (five intraoperatively and one postoperatively) occurred in five patients (20 %): three vein lacerations (12 %) and two ureteral injuries (8 %), despite the presence of a double-J ureteral stent. The three vein damages were repaired or ligated by a vascular surgeon. One of the two ureteral injuries led to a secondary nephrectomy after end-to-end anastomosis failure; the other necessitated secondary laparotomy for small bowel obstruction. Anterior revision of the lumbar spine is technically challenging and is associated with a high rate of vascular or urologic complications. Therefore, the potential complications of the procedure must be weighted against its benefits. When iterative anterior lumbar approach is mandatory, exposure should be performed by an access surgeon in specialized centers that have ready access to vascular and urologic surgeons.",{"EN":1689},"Analysis of intraoperative difficulties and management of operative complications in revision anterior exposure of the lumbar spine: a report of 25 consecutive cases",{"VOID":1691},"[\"12980659627783857248\"]",{"VOID":1693},"Wood KB, Schwender JD (2000) Lumbar intervertebral cages: limitations and complications. Oper Tech Orthop 10(4):320–324\nGumbs AA, Hanan S, Yue JJ, Shah RV, Sumpio B (2007) Revision open anterior approaches for spine procedures. Spine J 7(3):280–285. doi:10.1016\u002Fj.spinee.2006.05.015\nBrau SA, Delamarter RB, Schiffman ML, Williams LA, Watkins RG (2004) Vascular injury during anterior lumbar surgery. Spine J 4(4):409–412. doi:10.1016\u002Fj.spinee.2003.12.003\nEscobar E, Transfeldt E, Garvey T, Ogilvie J, Graber J, Schultz L (2003) Video-assisted versus open anterior lumbar spine fusion surgery: a comparison of four techniques and complications in 135 patients. Spine (Phila Pa 1976) 28(7):729–732. doi:10.1097\u002F01.BRS.0000051912.04345.96\nSasso RC, Best NM, Mummaneni PV, Reilly TM, Hussain SM (2005) Analysis of operative complications in a series of 471 anterior lumbar interbody fusion procedures. Spine (Phila Pa 1976) 30(6):670–674. pii: 00007632-200503150-00014\nGumbs AA, Shah RV, Yue JJ, Sumpio B (2005) The open anterior paramedian retroperitoneal approach for spine procedures. Arch Surg 140(4):339–343. doi:10.1001\u002Farchsurg.140.4.339\nIsiklar ZU, Lindsey RW, Coburn M (1996) Ureteral injury after anterior lumbar interbody fusion. A case report. Spine (Phila Pa 1976) 21(20):2379–2382\nGuingrich JA, McDermott JC (2000) Ureteral injury during laparoscopy-assisted anterior lumbar fusion. Spine (Phila Pa 1976) 25(12):1586–1588\nde Maat GH, Punt IM, van Rhijn LW, Schurink GW, van Ooij A (2009) Removal of the Charite lumbar artificial disc prosthesis: surgical technique. J Spinal Disord Tech 22(5):334–339. doi:10.1097\u002FBSD.0b013e3181761d0c\nGayer G, Caspi I, Garniek A, Hertz M, Apter S (2002) Perirectal urinoma from ureteral injury incurred during spinal surgery mimicking rectal perforation on computed tomography scan. Spine (Phila Pa 1976) 27(20):E451–E453. doi:10.1097\u002F01.BRS.0000029270.69311.7B\nSchwender JD, Casnellie MT, Perra JH, Transfeldt EE, Pinto MR, Denis F, Garvey TA, Polly DW, Mehbod AA, Dykes DC, Winter RB, Wroblewski JM (2009) Perioperative complications in revision anterior lumbar spine surgery: incidence and risk factors. Spine (Phila Pa 1976) 34(1):87–90. doi:10.1097\u002FBRS.0b013e3181918ad0\nPatel AA, Brodke DS, Pimenta L, Bono CM, Hilibrand AS, Harrop JS, Riew KD, Youssef JA, Vaccaro AR (2008) Revision strategies in lumbar total disc arthroplasty. Spine (Phila Pa 1976) 33(11):1276–1283. doi:10.1097\u002FBRS.0b013e3181714a1d\nNguyen HV, Akbarnia BA, van Dam BE, Raiszadeh K, Bagheri R, Canale S, Sylvain GM, Barone R, Bench G (2006) Anterior exposure of the spine for removal of lumbar interbody devices and implants. Spine (Phila Pa 1976) 31(21):2449–2453. doi:10.1097\u002F01.brs.0000240271.39583.b6\nPunt IM, Visser VM, van Rhijn LW, Kurtz SM, Antonis J, Schurink GW, van Ooij A (2008) Complications and reoperations of the SB Charite lumbar disc prosthesis: experience in 75 patients. Eur Spine J 17(1):36–43. doi:10.1007\u002Fs00586-007-0506-8\nJeon SH, Choi WG, Lee SH (2008) Anterior revision of a dislocated ProDisc prosthesis at the L4–5 level. J Spinal Disord Tech 21(6):448–450. doi:10.1097\u002FBSD.0b013e3181633a32\nLeary SP, Regan JJ, Lanman TH, Wagner WH (2007) Revision and explantation strategies involving the Charite lumbar artificial disc replacement. Spine (Phila Pa 1976) 32(9):1001–1011. doi:10.1097\u002F01.brs.0000260794.73938.93\nWagner WH, Regan JJ, Leary SP, Lanman TH, Johnson JP, Rao RK, Cossman DV (2006) Access strategies for revision or explantation of the Charite lumbar artificial disc replacement. J Vasc Surg 44(6):1266–1272. doi:10.1016\u002Fj.jvs.2006.07.046\nDavid T (2005) Revision of a Charite artificial disc 9.5 years in vivo to a new Charite artificial disc: case report and explant analysis. Eur Spine J 14(5):507–511. doi:10.1007\u002Fs00586-004-0842-x\nFaciszewski T, Winter RB, Lonstein JE, Denis F, Johnson L (1995) The surgical and medical perioperative complications of anterior spinal fusion surgery in the thoracic and lumbar spine in adults. A review of 1223 procedures. Spine (Phila Pa 1976) 20(14):1592–1599\nBaker JK, Reardon PR, Reardon MJ, Heggeness MH (1993) Vascular injury in anterior lumbar surgery. Spine (Phila Pa 1976) 18(15):2227–2230\nKozak JA, Heilman AE, O’Brien JP (1994) Anterior lumbar fusion options. Technique and graft materials. Clin Orthop Relat Res 300:45–51\nKuslich SD, Ulstrom CL, Griffith SL, Ahern JW, Dowdle JD (1998) The Bagby and Kuslich method of lumbar interbody fusion. History, techniques, and 2-year follow-up results of a United States prospective, multicenter trial. Spine (Phila Pa 1976) 23(11):1267–1278 (discussion 1279)\nRay CD (1997) Threaded titanium cages for lumbar interbody fusions. Spine (Phila Pa 1976) 22(6):667–679 (discussion 679–680)\nChiriano J, Abou-Zamzam AM Jr, Urayeneza O, Zhang WW, Cheng W (2009) The role of the vascular surgeon in anterior retroperitoneal spine exposure: preservation of open surgical training. J Vasc Surg 50(1):148–151. doi:10.1016\u002Fj.jvs.2009.01.007\nHolt RT, Majd ME, Vadhva M, Castro FP (2003) The efficacy of anterior spine exposure by an orthopedic surgeon. J Spinal Disord Tech 16(5):477–486\nJarrett CD, Heller JG, Tsai L (2009) Anterior exposure of the lumbar spine with and without an “access surgeon”: morbidity analysis of 265 consecutive cases. J Spinal Disord Tech 22(8):559–564. doi:10.1097\u002FBSD.0b013e318192e326\nScaduto AA, Gamradt SC, Yu WD, Huang J, Delamarter RB, Wang JC (2003) Perioperative complications of threaded cylindrical lumbar interbody fusion devices: anterior versus posterior approach. J Spinal Disord Tech 16(6):502–507\nTiusanen H, Seitsalo S, Osterman K, Soini J (1995) Retrograde ejaculation after anterior interbody lumbar fusion. Eur Spine J 4(6):339–342\nSasso RC, Kenneth Burkus J, LeHuec JC (2003) Retrograde ejaculation after anterior lumbar interbody fusion: transperitoneal versus retroperitoneal exposure. Spine (Phila Pa 1976) 28(10):1023–1026. doi:10.1097\u002F01.BRS.0000062965.47779.EB",{"VOID":1695},"10.1007\u002Fs00586-012-2524-4","2024-05-13T16:07:31.993+00:00","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00586-012-2524-4",[1699,1714,1727,1740],{"id":1700,"sortIndex":19,"researcher":18,"roles":1701,"affiliations":1702,"properties":1711,"displayName":1713,"givenName":18,"familyName":18},"058f80fb-d8f5-486a-ba28-251ef9d04c36",[224],[1703],{"id":1704,"sortIndex":19,"affiliation":1705,"properties":18},"4d19076f-8f40-4b99-8c30-61cb3c495af6",{"id":1704,"createTime":18,"updateTime":18,"relativeEntities":1706,"slug":18,"properties":1707,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1710,"statistic":18},[],{"title":1708},{"VI":1709},"Institut du Rachis, Service de Chirurgie Orthopédique et Traumatologique, Hôpital Henri Mondor, AP-HP, UPEC, Creteil Cedex, 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