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established predictors of survival may no longer apply in the current era of cystic fibrosis (CF) care. 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Malnourished patients (hazard ratio (HR) 2.1, 95% CI 1.6–2.8), those with multiple exacerbations (HR 4.5, 95% CI 3.2–6.4) and women with CF-related diabetes (HR 1.8, 95% CI 1.2–2.7) were at increased risk of death.\u003C\u002Fjats:p>\u003Cjats:p>Life expectancy in Canadians with CF is increasing. Modifiable risk factors such as malnutrition and pulmonary exacerbations are associated with an increased risk of death. 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There was no difference in release of IL-6, expression of intercellular adhesion molecule-1 (CD54), and AM stimulation of allogeneic T-cells, between children <2 yrs and > or =2 yrs of age. It was concluded that the capacity of alveolar macrophage to stimulate T-cells is not enhanced in early childhood, and that immaturity of alveolar macrophage function may contribute to an increased susceptibility to respiratory infections in this age group.\u003C\u002Fjats:p>",{"EN":1320},"Alveolar macrophage immaturity in infants and young 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induces chronic obstructive pulmonary disease (COPD) and is associated with airway inflammation and airway hyperresponsiveness (AHR). It has not been studied in COPD whether direct (methacholine) and indirect (adenosine-5'-monophosphate (AMP)) stimuli are associated with airway inflammation and neither whether smoking cessation improves these features.\u003C\u002Fjats:p>\u003Cjats:p>The current authors cross-sectionally investigated the relationship of AHR to methacholine and AMP with lung function and inflammatory cells in the sputum of 33 smokers with COPD. In addition, changes in these parameters were prospectively assessed in 14 smokers who successfully quit smoking for 1 yr.\u003C\u002Fjats:p>\u003Cjats:p>The presence of AHR to both methacholine and AMP was associated with lower lung function, but not with sputum inflammation. AHR to methacholine and AMP improved significantly after a 1-yr smoking cessation, yet this was unrelated to changes in sputum cell counts. The numbers of neutrophils and epithelial cells significantly increased with smoking cessation.\u003C\u002Fjats:p>\u003Cjats:p>Both direct and indirect airway hyperresponsiveness are associated with lower lung function, but not with sputum inflammation in chronic obstructive pulmonary disease. Interestingly, 1-yr smoking cessation improved both direct and indirect airway hyperresponsiveness, yet without a significant association with changes in lung function or sputum inflammation. Thus, other factors are likely to induce these improvements,\u003Cjats:italic>e.g.\u003C\u002Fjats:italic>a reduction in stimulation of irritant receptors, airway wall changes or mucus hypersecretion.\u003C\u002Fjats:p>",{"EN":1492},"Smoking cessation improves both direct and indirect airway hyperresponsiveness in COPD",{"VOID":1494},"15358697",{"VOID":1496},"10.1183\u002F09031936.04.00117603",[122],"http:\u002F\u002Fpublications.ersnet.org\u002Flookup\u002Fdoi\u002F10.1183\u002F09031936.04.00117603",[1500],{"id":1501,"sortIndex":25,"researcher":24,"roles":1502,"affiliations":1503,"properties":1512,"displayName":1516,"givenName":24,"familyName":24},"7331af83-83f6-4bb3-8965-1c07e95d0433",[],[1504],{"id":1505,"sortIndex":25,"affiliation":1506,"properties":24},"0a868eb5-d17d-451c-bce6-0ba13e095ac6",{"id":1505,"createTime":24,"updateTime":24,"relativeEntities":1507,"slug":24,"properties":1508,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1511,"statistic":24},[],{"title":1509},{"EN":1510},"University Hospital Groningen, Dept of Pathology, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.",[],{"orcid":1513,"title":1515,"openalex":1517},{"VOID":1514},"https:\u002F\u002Forcid.org\u002F0000-0003-3009-0919",{"EN":1516},"Brigitte W.M. 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patients with sleep apnoea\u002Fhypopnoea syndrome (SAHS) are middle-aged men. As there are conflicting data on the effects of age and gender on upper airway calibre, we tested the hypothesis that increasing age and the male sex predispose to upper airway narrowing in normal subjects. We measured upper airway calibre using acoustic reflection in 60 men and 54 women (median 35, range 16-74 yrs) both seated and supine. All upper airway dimensions, except oropharyngeal junction (OPJ), decreased with increasing age in both men and women (r > -0.24, p < or = 0.05) while supine (r2 > 0.06). Men had greater changes in airway area at OPJ on lying down (mean (SEM) 0.5 (0.1), 0.2 (0.1) cm2; p < 0.02). Men had greater body mass indices (mean (SD) 26 (4), 24 (4) kg.m-2; p = 0.04), and larger neck circumferences (mean (SD) 38 (3), 33 (2) cm; p < 0.0001) than women. For any body mass index, neck circumference was larger in men than women (p < 0.001). 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