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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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M., 1972, Immunology, 22, 959",{},{"id":28,"text":1195,"url":28,"identifiers":1196},"10.1172\u002FJCI106545",{"doi":1195},{"id":28,"text":1198,"url":28,"identifiers":1199},"10.1084\u002Fjem.135.2.165",{"doi":1198},{"id":28,"text":1201,"url":28,"identifiers":1202},"10.1073\u002Fpnas.69.7.1934",{"doi":1201},{"id":28,"text":1204,"url":28,"identifiers":1205},"10.1084\u002Fjem.99.2.167",{"doi":1204},{"id":28,"text":1207,"url":28,"identifiers":1208},"Sarkar S., 1973, J. Immunol., 110, 1222, 10.4049\u002Fjimmunol.110.5.1222",{"doi":1209},"10.4049\u002Fjimmunol.110.5.1222",{"id":28,"text":1211,"url":28,"identifiers":1212},"Cebra J. J., 1965, J. Immunol., 95, 230, 10.4049\u002Fjimmunol.95.2.230",{"doi":1213},"10.4049\u002Fjimmunol.95.2.230",{"id":28,"text":1215,"url":28,"identifiers":1216},"Cunningham A. J., 1968, Immunology, 14, 599",{},{"id":28,"text":1218,"url":28,"identifiers":1219},"10.3181\u002F00379727-132-34264",{"doi":1218},{"id":28,"text":1221,"url":28,"identifiers":1222},"10.1038\u002F228062a0",{"doi":1221},{"id":28,"text":1224,"url":28,"identifiers":1225},"10.1084\u002Fjem.136.2.331",{"doi":1224},{"id":28,"text":1227,"url":28,"identifiers":1228},"10.1084\u002Fjem.126.3.423",{"doi":1227},{"id":28,"text":1230,"url":28,"identifiers":1231},"Canty T. G., 1970, J. Nat. Cancer Inst., 45, 761",{},{"id":28,"text":1233,"url":28,"identifiers":1234},"10.1016\u002F0019-2791(69)90179-7",{"doi":1233},false,{"id":1237,"createTime":1238,"updateTime":1239,"relativeEntities":1240,"slug":1241,"properties":1242,"entityType":1059,"verifyStatus":26,"verifyTime":1258,"verifyNote":1060,"languages":1259,"translateLanguages":1260,"viewCount":32,"primaryUrl":1261,"fullTextUrl":28,"authors":1262,"publicationType":1099,"publisherRelationship":1297,"citationCount":1352,"citationInfo":1353,"publishDate":1356,"publishYear":1354,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":1357,"openAccess":28,"references":1358,"isForceReanalyzing":1235},"6e4a600d-2fd2-4eb8-a538-cda9a0515a1e","2024-10-12T01:40:36.102+00:00","2025-02-22T21:10:41.312+00:00",[],"Derivation-of-specific-antibody-producing-tissue-culture-and-tumor-lines-by-cell-fusion",{"mag":1243,"keywords":1245,"openalex":1246,"abstract":1248,"title":1251,"pm":1254,"doi":1256},{"VOID":1244},"2089276240",{"VI":1046},{"VOID":1247},"W2089276240",{"EN":1249,"VI":1250},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Cell fusion techniques have been used to produce hybrids between myeloma cells and antibody‐producing cells. The hybrid lines derived are permanently adapted to grow in tissue culture and are capable of inducing antibody‐producing tumors in mice.\u003C\u002Fjats:p>\u003Cjats:p>Spleens from mice immunized against sheep red blood cells (SRBC) were fused to an 8‐azaguanine‐resistant clone (X63‐Ag8) of MOPC 21 myeloma. Over 50 % of the derived hybrid lines produce and secrete immunoglobulins different from the MOPC 21 myeloma. About 10 % of the hybrid lines exhibit anti‐SRBC activity. The high proportion of antibody‐producing hybrids suggests that the fusion involves a restricted fraction of the spleen cell population, probably cells committed to antibody production.\u003C\u002Fjats:p>\u003Cjats:p>In order to avoid the presence of the MOPC 21 heavy chain in the specific hybrids, another myeloma cell line (NSI\u002F1‐Ag4–1) has been used. This is a nonsecreting variant of the MOPC 21 myeloma which does not express heavy chains.\u003C\u002Fjats:p>\u003Cjats:p>Three anti‐SRBC (probably of the μ, γ\u003Cjats:sub>2b\u003C\u002Fjats:sub> and γ\u003Cjats:sub>1\u003C\u002Fjats:sub> classes, respectively) and two anti‐2,4,6‐trinitrophenyl (of the μ class) antibody‐producing hybrids have been repeatedly cloned. By random selection and by selection of specific clones according to their lytic activity (clone plaque selection), a number of different lines have been constructed. Such lines express different combinations of the four possible chains of each hybrid line: the myeloma γ and \u003Cjats:italic>k\u003C\u002Fjats:italic> chains and the specific antibody heavy and light chains. In three cases (Sp1, Sp2 and Sp7) it is shown that only the specific H and L combination has activity and that the myeloma chains are unable to substitute for them. In most cases lines have been derived which no longer express the MOPC 21 chains but only the specific antibody chains.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Các kỹ thuật hợp nhất tế bào đã được sử dụng để tạo ra các dòng tế bào lai giữa tế bào u tủy và tế bào sản xuất kháng thể. Các dòng lai thu được đã thích nghi vĩnh viễn để phát triển trong nuôi cấy mô và có khả năng gây ra các khối u sản xuất kháng thể ở chuột.\u003C\u002Fjats:p>\u003Cjats:p>Lách từ chuột được miễn dịch với tế bào máu đỏ cừu (SRBC) đã được hợp nhất với một dòng tế bào 8-azaguanine kháng (X63-Ag8) của u tủy MOPC 21. Hơn 50% các dòng lai thu được sản xuất và tiết ra các immunoglobulin khác với u tủy MOPC 21. Khoảng 10% các dòng lai thể hiện hoạt tính chống SRBC. Tỷ lệ cao của các tế bào lai sản xuất kháng thể cho thấy rằng quá trình hợp nhất liên quan đến một phần giới hạn của quần thể tế bào lách, có khả năng là các tế bào đã cam kết sản xuất kháng thể.\u003C\u002Fjats:p>\u003Cjats:p>Để tránh sự hiện diện của chuỗi nặng MOPC 21 trong các dòng lai đặc hiệu, một dòng tế bào u tủy khác (NSI\u002F1-Ag4–1) đã được sử dụng. Đây là một biến thể không tiết của u tủy MOPC 21 mà không biểu hiện các chuỗi nặng.\u003C\u002Fjats:p>\u003Cjats:p>Ba dòng lai sản xuất kháng thể chống SRBC (có thể thuộc các lớp μ, γ\u003Cjats:sub>2b\u003C\u002Fjats:sub> và γ\u003Cjats:sub>1\u003C\u002Fjats:sub>, tương ứng) và hai dòng lai sản xuất kháng thể chống 2,4,6-trinitrophenyl (thuộc lớp μ) đã được nhân giống nhiều lần. Thông qua việc lựa chọn ngẫu nhiên và lựa chọn các dòng đặc hiệu dựa trên hoạt tính ly giải của chúng (lựa chọn mảng dòng), một số dòng khác nhau đã được xây dựng. Các dòng này thể hiện các sự kết hợp khác nhau của bốn chuỗi có thể có của mỗi dòng lai: các chuỗi γ và \u003Cjats:italic>k\u003C\u002Fjats:italic> từ u tủy và các chuỗi kháng thể nặng và nhẹ đặc hiệu. Trong ba trường hợp (Sp1, Sp2 và Sp7) cho thấy rằng chỉ có sự kết hợp chuỗi nặng và nhẹ đặc hiệu có hoạt tính và rằng các chuỗi từ u tủy không thể thay thế cho chúng. Trong hầu hết các trường hợp, các dòng đã được thu được không còn biểu hiện các chuỗi MOPC 21 nữa mà chỉ biểu hiện các chuỗi kháng thể đặc hiệu.",{"EN":1252,"VI":1253},"Derivation of specific antibody‐producing tissue culture and tumor lines by cell fusion","Sự phát triển của các dòng tế bào và khối u sản xuất kháng thể đặc hiệu qua kỹ thuật hợp nhất tế bào",{"VOID":1255},"825377",{"VOID":1257},"10.1002\u002Feji.1830060713","2024-10-12T01:40:36.101+00:00",[31],[30],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Feji.1830060713",[1263,1280],{"id":1264,"sortIndex":32,"researcher":28,"roles":1265,"affiliations":1266,"properties":1275,"displayName":1277,"givenName":28,"familyName":28},"35fc3a46-841d-4051-99fd-095eb893548c",[],[1267],{"id":1268,"sortIndex":32,"affiliation":1269,"properties":28},"1bba8769-fa94-4e2c-8c1d-b686e5d68470",{"id":1268,"createTime":28,"updateTime":28,"relativeEntities":1270,"slug":28,"properties":1271,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1274,"statistic":28},[],{"title":1272},{"EN":1273},"Medical Research Council Laboratory of Molecular Biology, Cambridge",[],{"title":1276,"openalex":1278},{"EN":1277},"Georges Köhler",{"VOID":1279},"A5040482719",{"id":1281,"sortIndex":40,"researcher":28,"roles":1282,"affiliations":1283,"properties":1292,"displayName":1294,"givenName":28,"familyName":28},"4e8a7ca8-2fed-41d3-82d1-0c79738116c2",[],[1284],{"id":1285,"sortIndex":32,"affiliation":1286,"properties":28},"e6173df1-5e1d-49ed-815a-2841ede3858b",{"id":1285,"createTime":28,"updateTime":28,"relativeEntities":1287,"slug":28,"properties":1288,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1291,"statistic":28},[],{"title":1289},{"VI":1290},"MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, England",[],{"title":1293,"openalex":1295},{"EN":1294},"César 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2F0014-4827(70)90489-1",{"doi":1375},{"id":28,"text":1378,"url":28,"identifiers":1379},"10.1002\u002Feji.1830030305",{"doi":1378},{"id":28,"text":1381,"url":28,"identifiers":1382},"10.1152\u002Fphysrev.1972.52.3.631",{"doi":1381},{"id":28,"text":1384,"url":28,"identifiers":1385},"10.1126\u002Fscience.140.3565.405",{"doi":1384},{"id":28,"text":1218,"url":28,"identifiers":1387},{"doi":1218},{"id":28,"text":1389,"url":28,"identifiers":1390},"10.1038\u002F219066a0",{"doi":1389},{"id":28,"text":1392,"url":28,"identifiers":1393},"Milstein C.andKöhler G. in Haber E. (Ed.)The Future of Antibodies in Human Diagnosis and Therapy 1976 in press.",{},{"id":28,"text":1395,"url":28,"identifiers":1396},"10.1038\u002F238339a0",{"doi":1395},{"id":28,"text":1398,"url":28,"identifiers":1399},"10.1016\u002FB978-0-12-637150-5.50031-6",{"doi":1398},{"id":1401,"createTime":1402,"updateTime":1403,"relativeEntities":1404,"slug":1405,"properties":1406,"entityType":1059,"verifyStatus":26,"verifyTime":1402,"verifyNote":1060,"languages":1423,"translateLanguages":1424,"viewCount":32,"primaryUrl":1425,"fullTextUrl":28,"authors":1426,"publicationType":1099,"publisherRelationship":1461,"citationCount":1515,"citationInfo":1516,"publishDate":1519,"publishYear":1517,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":1520,"openAccess":28,"references":1521,"isForceReanalyzing":1235},"dc1020cf-e9fc-4cbb-8e55-59f672bd04a8","2024-11-25T23:00:24.006+00:00","2025-02-22T21:11:39.041+00:00",[],"F4-80-a-monoclonal-antibody-directed-specifically-against-the-mouse-macrophage",{"mag":1407,"keywords":1409,"openalex":1411,"abstract":1413,"title":1416,"pm":1419,"doi":1421},{"VOID":1408},"2065871536",{"VI":1410},"Kháng thể đơn dòng, tế bào thực bào, chuột, F4\u002F80, miễn dịch",{"VOID":1412},"W2065871536",{"EN":1414,"VI":1415},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>A hybridoma clone which secretes a macrophage (MΦ)‐specific monoclonal antibody, F4\u002F80, was produced by fusing spleen cells from a rat hyperimmunized with cultured thioglycollate‐induced mouse peritoneal MΦ with a mouse myeloma, NS1. Binding of antibody to primary cells and cell lines was detected by radioimmune indirect binding assay, autoradiography or fluorescence‐activated cell sorter analysis. F4\u002F80 binds to mouse MΦ from the peritoneal cavity or other sources, blood monocytes, MΦ derived from bone marrow precursors in culture and MΦ‐like cell lines, but not to other cells, including polymorphonuclear leukocytes, lymphocytes or fibroblasts. F4\u002F80 does not bind to MΦ via Fc receptors, is not cytotoxic and is of the rat IgG\u003Cjats:sub>2b\u003C\u002Fjats:sub> subclass. Since F4\u002F80 binds to all MΦ defined by adherence, morphology and immune phagocytosis, it provides a new marker to define the MΦ in the mouse. Large differences in expression of antigen F4\u002F80 were found, depending on intraperitoneal stimulation, time in culture and stage of maturation. Immunoprecipitation experiments demonstrated that the antigen F4\u002F80 is part of a component of Mr 160000 which is synthesized by the MΦ and, at least in part, exposed on the cell surface.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p> Một dòng tế bào hybridoma tiết ra một kháng thể đơn dòng đặc hiệu cho tế bào thực bào (MΦ), được gọi là F4\u002F80, đã được tạo ra bằng cách gộp các tế bào lách từ một con chuột đã được tiêm chủng quá mức với tế bào MΦ của chuột được nuôi cấy bằng thioglycollate và kết hợp với một dòng tế bào u bạch cầu chuột, NS1. Sự kết hợp của kháng thể với các tế bào chính và dòng tế bào đã được phát hiện bằng phương pháp phân tích liên kết gián tiếp bằng miễn dịch phóng xạ, hình ảnh tự động hoặc phân tích dòng tế bào kích hoạt bằng huỳnh quang. F4\u002F80 liên kết với tế bào MΦ của chuột từ khoang bụng hoặc các nguồn khác, tế bào đơn nhân trong máu, MΦ phát triển từ các tiền thân tủy xương trong nuôi cấy và các dòng tế bào tương tự MΦ, nhưng không liên kết với các tế bào khác, bao gồm bạch cầu đa nhân và lympho. F4\u002F80 không liên kết với MΦ thông qua các thụ thể Fc, không có tính độc tế bào và thuộc nhóm IgG\u003Cjats:sub>2b\u003C\u002Fjats:sub> của chuột. Do F4\u002F80 liên kết với tất cả các MΦ được xác định bởi độ bám dính, hình thái và khả năng thực bào miễn dịch, nó cung cấp một dấu hiệu mới để xác định MΦ ở chuột. Có sự khác biệt lớn trong việc biểu hiện kháng nguyên F4\u002F80, phụ thuộc vào sự kích thích nội bụng, thời gian nuôi cấy và giai đoạn trưởng thành. Các thí nghiệm kết tủa miễn dịch đã chứng minh rằng kháng nguyên F4\u002F80 là một phần của một thành phần có khối lượng phân tử 160000 được tổng hợp bởi MΦ và, ít nhất một phần, được phơi bày trên bề mặt tế bào.\u003C\u002Fjats:p>",{"EN":1417,"VI":1418},"F4\u002F80, a monoclonal antibody directed specifically against the mouse macrophage","F4\u002F80, một kháng thể đơn dòng nhắm vào tế bào thực bào chuột",{"VOID":1420},"7308288",{"VOID":1422},"10.1002\u002Feji.1830111013",[31],[30],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Feji.1830111013",[1427,1444],{"id":1428,"sortIndex":32,"researcher":28,"roles":1429,"affiliations":1430,"properties":1439,"displayName":1441,"givenName":28,"familyName":28},"72e5cba8-5182-4ae6-8b3f-d82a89ea3de0",[],[1431],{"id":1432,"sortIndex":32,"affiliation":1433,"properties":28},"77aa3cba-ff5f-481d-a205-1b8301131f56",{"id":1432,"createTime":28,"updateTime":28,"relativeEntities":1434,"slug":28,"properties":1435,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1438,"statistic":28},[],{"title":1436},{"EN":1437},"Sir William Dunn School of Pathology, University of Oxford, Oxford",[],{"title":1440,"openalex":1442},{"EN":1441},"Jonathan M. 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Immunol, 114, 898, 10.4049\u002Fjimmunol.114.2_Part_2.898",{"doi":1549},"10.4049\u002Fjimmunol.114.2_Part_2.898",{"id":28,"text":1551,"url":28,"identifiers":1552},"10.4049\u002Fjimmunol.114.2_Part_2.894",{"doi":1551},{"id":28,"text":1554,"url":28,"identifiers":1555},"10.1007\u002F978-94-009-8793-7_13",{"doi":1554},{"id":28,"text":1557,"url":28,"identifiers":1558},"10.1038\u002F277471a0",{"doi":1557},{"id":28,"text":1560,"url":28,"identifiers":1561},"10.1016\u002F0014-4827(79)90578-0",{"doi":1560},{"id":28,"text":1563,"url":28,"identifiers":1564},"10.1073\u002Fpnas.76.3.1400",{"doi":1563},{"id":28,"text":1566,"url":28,"identifiers":1567},"Harris H., 1977, J. Cell Sci., 24, 217, 10.1242\u002Fjcs.24.1.217",{"doi":1568},"10.1242\u002Fjcs.24.1.217",{"id":28,"text":1570,"url":28,"identifiers":1571},"Sanford K., 1948, J. Natl. 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C., 1966, Fundamentals of Immunology, 195",{},{"id":28,"text":1617,"url":28,"identifiers":1618},"10.1002\u002Feji.1830090410",{"doi":1617},{"id":28,"text":1602,"url":28,"identifiers":1620},{"doi":1602},{"id":28,"text":1622,"url":28,"identifiers":1623},"10.1084\u002Fjem.154.1.168",{"doi":1622},{"id":28,"text":1625,"url":28,"identifiers":1626},"10.1084\u002Fjem.149.1.84",{"doi":1625},{"id":28,"text":1628,"url":28,"identifiers":1629},"10.1084\u002Fjem.154.1.60",{"doi":1628},{"id":28,"text":1631,"url":28,"identifiers":1632},"10.1042\u002Fbj1870001",{"doi":1631},{"id":28,"text":1634,"url":28,"identifiers":1635},"10.1084\u002Fjem.150.3.607",{"doi":1634},{"id":28,"text":1637,"url":28,"identifiers":1638},"10.1084\u002Fjem.152.4.1048",{"doi":1637},{"id":28,"text":1640,"url":28,"identifiers":1641},"10.1084\u002Fjem.152.6.1699",{"doi":1640},{"id":1643,"createTime":1644,"updateTime":1645,"relativeEntities":1646,"slug":1647,"properties":1648,"entityType":1059,"verifyStatus":26,"verifyTime":1644,"verifyNote":1060,"languages":1664,"translateLanguages":1665,"viewCount":32,"primaryUrl":1666,"fullTextUrl":28,"authors":1667,"publicationType":1099,"publisherRelationship":1704,"citationCount":143,"citationInfo":1758,"publishDate":1765,"publishYear":1759,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":1766,"openAccess":28,"references":1767,"isForceReanalyzing":1235},"db3d80bf-8d4d-4556-8fe5-913c4aa94ac6","2024-10-05T04:42:05.398+00:00","2025-02-22T21:12:35.665+00:00",[],"IL-6-Regulator-of-Treg-Th17-balance",{"mag":1649,"keywords":1651,"openalex":1652,"abstract":1654,"title":1657,"pm":1660,"doi":1662},{"VOID":1650},"2028195000",{"VI":1046},{"VOID":1653},"W2028195000",{"EN":1655,"VI":1656},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>IL‐6 is a pleiotropic cytokine involved in the physiology of virtually every organ system. Recent studies have demonstrated that IL‐6 has a very important role in regulating the balance between IL‐17‐producing Th17 cells and regulatory T cells (Treg). The two T‐cell subsets play prominent roles in immune functions: Th17 cell is a key player in the pathogenesis of autoimmune diseases and protection against bacterial infections, while Treg functions to restrain excessive effector T‐cell responses. IL‐6 induces the development of Th17 cells from naïve T cells together with TGF‐β; in contrast, IL‐6 inhibits TGF‐β‐induced Treg differentiation. Dysregulation or overproduction of IL‐6 leads to autoimmune diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA), in which Th17 cells are considered to be the primary cause of pathology. Given the critical role of IL‐6 in altering the balance between Treg and Th17 cells, controlling IL‐6 activities is potentially an effective approach in the treatment of various autoimmune and inflammatory diseases. Here, we review the role of IL‐6 in regulating Th17\u002FTreg balance and describe the critical functions of IL‐6 and Th17 in immunity and immune‐pathology.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>IL‐6 là một cytokine đa tác dụng tham gia vào sinh lý của hầu hết các hệ thống cơ quan. Các nghiên cứu gần đây đã chứng minh rằng IL‐6 có vai trò rất quan trọng trong việc điều chỉnh sự cân bằng giữa các tế bào Th17 sản xuất IL‐17 và các tế bào T điều hòa (Treg). Hai nhóm tế bào T này đóng vai trò nổi bật trong các chức năng miễn dịch: tế bào Th17 là một yếu tố chủ chốt trong bệnh sinh của các bệnh tự miễn và bảo vệ chống lại các nhiễm khuẩn do vi khuẩn, trong khi Treg có chức năng kiềm chế các phản ứng của tế bào T hiệu ứng quá mức. IL‐6 kích thích sự phát triển của các tế bào Th17 từ các tế bào T chưa trưởng thành cùng với TGF‐β; ngược lại, IL‐6 ức chế sự phân hóa Treg do TGF‐β gây ra. Sự mất cân bằng hoặc sản xuất quá mức IL‐6 dẫn đến các bệnh tự miễn như xơ cứng đa diễn (MS) và viêm khớp dạng thấp (RA), trong đó các tế bào Th17 được coi là nguyên nhân chính của bệnh sinh. Với vai trò quan trọng của IL‐6 trong việc thay đổi sự cân bằng giữa tế bào Treg và Th17, việc kiểm soát hoạt động của IL‐6 tiềm năng là một cách tiếp cận hiệu quả trong điều trị các bệnh tự miễn và viêm nhiễm khác nhau. Ở đây, chúng tôi xem xét vai trò của IL‐6 trong việc điều chỉnh cân bằng Th17\u002FTreg và mô tả các chức năng quan trọng của IL‐6 và Th17 trong miễn dịch và bệnh lý miễn dịch.\u003C\u002Fjats:p>",{"EN":1658,"VI":1659},"IL‐6: Regulator of Treg\u002FTh17 balance","IL‐6: Người điều chỉnh cân bằng 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HGF has recently been proven to be identical to IFN‐β2, 26‐kDa protein and BSF‐2. HGF can be quantitated in a proliferation assay with the HGF‐dependent hybridoma cell line B13.29. By selection of an extremely sensitive variant of this cell line, we were able to measure HGF production of single cells. Limiting dilution analysis of the producing cells in combination with size, density and adherence characteristics showed that HGF is produced by monocytes and not by lymphocytes. There was no need for the monocytes to be stimulated but the cells did require the presence of serum. This serum requirement could be met by purified bovine serum albumin, but not by other proteins like ovalbumin or human γ‐globulin. 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Yêu cầu huyết thanh này có thể được đáp ứng bởi albumin huyết thanh bò tinh khiết, nhưng không phải bởi các protein khác như ovalbumin hay γ-globulin của người. 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A., 1976, Blood, 48, 743, 10.1182\u002Fblood.V48.5.743.743",{"doi":2170},"10.1182\u002Fblood.V48.5.743.743",{"id":28,"text":2172,"url":28,"identifiers":2173},"10.1111\u002Fj.1399-0039.1979.tb00786.x",{"doi":2172},{"id":2175,"createTime":2176,"updateTime":2177,"relativeEntities":2178,"slug":2179,"properties":2180,"entityType":1059,"verifyStatus":26,"verifyTime":2196,"verifyNote":1060,"languages":2197,"translateLanguages":2198,"viewCount":32,"primaryUrl":2199,"fullTextUrl":28,"authors":2200,"publicationType":1099,"publisherRelationship":2237,"citationCount":2292,"citationInfo":2293,"publishDate":2296,"publishYear":2294,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":2297,"openAccess":28,"references":2298,"isForceReanalyzing":1235},"4e37ebde-1350-42f3-857b-6ccc75bb3ed2","2024-10-10T12:03:51.316+00:00","2025-02-22T21:14:33.354+00:00",[],"Establishment-of-mouse-cell-lines-which-constitutively-secrete-large-quantities-of-interleukin-2-3-4-or-5-using-modified-cDNA-expression-vectors",{"mag":2181,"keywords":2183,"openalex":2184,"abstract":2186,"title":2189,"pm":2192,"doi":2194},{"VOID":2182},"1997257161",{"VI":1046},{"VOID":2185},"W1997257161",{"EN":2187,"VI":2188},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Mouse cell lines of different lineages have been established which constitutively secrete large quantities of recombinant mouse interleukins (mIL2, mIL3, mIL4 or mIL5). An existing bovine papilloma virus‐based expression vector, pBV‐lMTHA, was modified to allow transformed X63Ag8‐653 myeloma cells, NIH 3T3 fibroblasts and C127 mammary tumor cells to stably carry multiple copies of the vector, to express the inserted cDNA encoding a single interleukin constitutively, and to secrete the interleukin in high quantities.\u003C\u002Fjats:p>\u003Cjats:p>Cell lines transformed with mIL2 cDNA stably carried 30–100 copies of the plasmid per cell and constitutively secreted biologically active mIL2 in quantities similar to those produced by murine EL4 thymoma cells or rat spleen cells stimulated with mitogens. Deletion of the 3′ untranslated region containing AT‐rich sequences from the mIL2 cDNA resulted in a 100‐fold increase in the constitutive production and secretion of mIL2 by the transformants. Addition of a heavy metal further increased the production 2 to 6‐fold. Cells transformed with 3′‐deleted mIL3 cDNA constitutively secreted 300–1000 times higher activities of mIL3 than the myelomonocytic leukemia line WEHI 3. mIL 4 produced by the similar transformants induced [\u003Cjats:sup>3\u003C\u002Fjats:sup>H]thymidine uptake of a T cell line, a mast cell line and B leukemia cells, and enhanced the production of IgG\u003Cjats:sub>1\u003C\u002Fjats:sub> by B cells. IL 4 liters were 150 times higher than those produced by the concanavalin A‐stimulated T cell line 2.19. mIL 5 was secreted by similar transformants at 10‐fold higher titers than those produced by concanavalin A‐stimulated 2.19 T cells, as judged by the proliferation and maturation of B cell leukemia BCL1. The expression vectors should be useful in establishing eukaryotic cell lines producing proteins from full length cDNA clones at higher rates. The established cell lines secreting IL2, 3, 4 or 5 at high rate should be useful sources for these interleukins in the investigation of their function in the immune system.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Các dòng tế bào chuột thuộc các dòng di truyền khác nhau đã được thiết lập, có khả năng tiết ra liên tục một lượng lớn interleukin chuột tái tổ hợp (mIL2, mIL3, mIL4 hoặc mIL5). Một vector biểu hiện dựa trên virus papilloma bò hiện có, pBV-lMTHA, đã được sửa đổi để cho phép các tế bào myeloma X63Ag8-653, tế bào fibroblast NIH 3T3 và tế bào khối u vú C127 mang ổn định nhiều bản sao của vector, biểu hiện cDNA được chèn mã hóa một interleukin duy nhất một cách liên tục, và tiết ra interleukin với số lượng lớn. \u003C\u002Fjats:p>\u003Cjats:p>Các dòng tế bào biến đổi với cDNA mIL2 mang ổn định từ 30 đến 100 bản sao của plasmid mỗi tế bào và tiết ra mIL2 sinh học hoạt động một cách liên tục với số lượng tương tự như được sản xuất bởi các tế bào thymo EL4 chuột hoặc các tế bào lách chuột đã được kích thích bằng mitogen. Việc xóa bỏ vùng không dịch mã 3′ chứa các chuỗi giàu AT khỏi cDNA mIL2 đã dẫn đến việc tăng gấp 100 lần trong khả năng sản xuất và tiết ra mIL2 bởi các biến thể. Sự bổ sung của kim loại nặng đã tăng cường sản xuất từ 2 đến 6 lần. Các tế bào biến đổi với cDNA mIL3 đã bị xóa 3′ tiết ra hoạt tính mIL3 cao hơn từ 300 đến 1000 lần so với dòng bạch cầu đơn nhân myelomonocytic WEHI 3. mIL 4 do các biến thể tương tự sản xuất đã kích thích khả năng hấp thu [\u003Cjats:sup>3\u003C\u002Fjats:sup>H]thymidine của dòng tế bào T, dòng tế bào mast và các tế bào bạch cầu B, đồng thời tăng cường sản xuất IgG\u003Cjats:sub>1\u003C\u002Fjats:sub> bởi các tế bào B. Nồng độ IL 4 cao hơn 150 lần so với nồng độ được sản xuất bởi dòng tế bào T 2.19 được kích thích bằng concanavalin A. mIL 5 đã được tiết ra bởi các biến thể tương tự ở titer cao hơn 10 lần so với các tế bào T 2.19 được kích thích bằng concanavalin A, được đánh giá thông qua sự phát triển và trưởng thành của bạch cầu B BCL1. Các vector biểu hiện này được cho là hữu ích trong việc thiết lập các dòng tế bào eukaryote sản xuất protein từ các bản sao cDNA hoàn chỉnh với tỷ lệ cao hơn. Các dòng tế bào đã được thiết lập có khả năng tiết ra IL2, 3, 4 hoặc 5 với tỷ lệ cao nên là nguồn cung cấp hữu ích cho các interleukin này trong việc nghiên cứu chức năng của chúng trong hệ miễn dịch.\u003C\u002Fjats:p>",{"EN":2190,"VI":2191},"Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors","Thiết lập các dòng tế bào chuột có khả năng tiết ra một lượng lớn interleukin 2, 3, 4 hoặc 5, sử dụng các vector biểu hiện cDNA đã được chỉnh 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The present hypothesis proposes that the germ‐cells of an animal carry a set of v‐genes determining the combining sites of antibodies directed against a complete set of a certain class of histocompatibility antigens of the species to which this animal belongs. The evolutionary development of this set of v‐genes in phylogeny is traced back to the requirements for cell to cell recognition in all metazoa. The hypothesis leads to a distinction between two populations of antigen‐sensitive cells. One population consists of cells forming antibodies against foreign antigens; these lymphocytes have arisen as mutants in clones descending from lymphocytic stem cells which expressed v‐genes belonging to the subset (subset S) coding for antibody against histocompatibility antigens that the individual happens to possess. The other population consists of allograft rejecting lymphocytes that express v‐genes of the remaining subset (subset A) coding for antibody against histocompatibility antigens of the species that the individual does not possess. The primary lymphoid organs are viewed as mutant‐breeding organs. In these organs (\u003Cjats:italic>e. g.\u003C\u002Fjats:italic> in the thymus), the proliferation of lymphocytes expressing the v‐genes of subset S and the subsequent suppression of the cells of these “forbidden” clones, leads to the selection of mutant cells expressing v‐genes that have been modified by spontaneous random somatic mutation. This process generates self‐tolerance as well as a diverse population of antigen‐sensitive cells that reflects antibody diversity. The proliferation in the primary lymphoid organs of lymphocytes expressing v‐genes of subset A generates the antigen‐sensitive cell population that is responsible for allo‐aggression.\u003C\u002Fjats:p>\u003Cjats:p>The theory explains how a functional immune system can develop through a selection pressure exerted by self‐antigens, starting during a period in early ontogeny that precedes clonal selection by foreign antigens. The hypothesis provides explanations for the variability of the N‐terminal regions of antibody polypeptide chains, for the dominant genetic control of specific immune responsiveness by histocompatibility alleles, for the relative preponderance of antigen‐sensitive cells directed against allogeneic histocompatibility antigens, for antibody‐idiotypes, for allelic exclusion, for the precommitment of any given antigen‐sensitive lymphocyte to form antibodies of only one molecular species and for the cellular dynamics in the primary lymphoid tissues.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Đặc hiệu kháng thể được xác định bởi các gen v cấu trúc mã hóa cho các chuỗi axit amin của các vùng biến đổi của chuỗi polypeptid kháng thể. Giả thuyết hiện tại đề xuất rằng các tế bào sinh dục của một động vật mang một tập hợp các gen v xác định các vị trí kết hợp của các kháng thể hướng về một tập hợp hoàn chỉnh của một lớp kháng nguyên tương thích mô nhất định mà loài động vật này thuộc về. Sự phát triển tiến hóa của tập hợp gen v này trong hệ sinh thái được truy tìm về yêu cầu cho việc nhận diện tế bào đến tế bào trong tất cả các dạng sống đa bào. Giả thuyết dẫn đến sự phân biệt giữa hai quần thể tế bào nhạy cảm với kháng nguyên. Một quần thể bao gồm các tế bào tạo thành kháng thể chống lại các kháng nguyên lạ; các lympho bào này đã xuất hiện như là các đột biến trong các dòng con của các tế bào gốc lympho biểu hiện các gen v thuộc tập con (tập con S) mã hóa cho kháng thể chống lại các kháng nguyên tương thích mô mà cá thể đó sở hữu. Quần thể còn lại bao gồm các lympho bào từ chối ghép tự do mà biểu hiện các gen v của tập con còn lại (tập con A) mã hóa cho kháng thể chống lại các kháng nguyên tương thích mô của loài mà cá thể đó không sở hữu. Các cơ quan lympho chính được coi là các cơ quan sinh đột biến. Trong các cơ quan này (\u003Cjats:italic>ví dụ\u003C\u002Fjats:italic> trong tuyến ức), sự phát triển của các lympho bào biểu hiện các gen v của tập con S và sự ức chế tiếp theo của các tế bào trong các dòng “cấm” này dẫn đến việc lựa chọn các tế bào đột biến biểu hiện các gen v đã được sửa đổi thông qua đột biến soma ngẫu nhiên. Quá trình này tạo ra sự tự dung nạp cũng như một quần thể đa dạng các tế bào nhạy cảm với kháng nguyên phản ánh sự đa dạng về kháng thể. Sự phát triển trong các cơ quan lympho chính của các lympho bào biểu hiện các gen v của tập con A tạo ra quần thể tế bào nhạy cảm với kháng nguyên mà chịu trách nhiệm cho sự tấn công allo.\u003C\u002Fjats:p>\u003Cjats:p>Thuyết này giải thích cách mà một hệ thống miễn dịch chức năng có thể phát triển thông qua áp lực lựa chọn do các kháng nguyên tự thân gây ra, bắt đầu trong một giai đoạn sớm trong phát triển mà diễn ra trước khi việc lựa chọn lâm sàng bởi các kháng nguyên lạ. Giả thuyết cung cấp các giải thích cho sự đa dạng của các vùng đầu N của các chuỗi polypeptid kháng thể, cho sự kiểm soát di truyền chiếm ưu thế của phản ứng miễn dịch đặc hiệu bởi các alen tương thích mô, cho sự ưu thế tương đối của các tế bào nhạy cảm với kháng nguyên hướng tới các kháng nguyên tương thích mô allo, cho các idiotype kháng thể, cho sự loại trừ alen, cho sự cam kết trước của bất kỳ lympho bào nhạy cảm với kháng nguyên nào để tạo ra kháng thể của chỉ một loại phân tử và cho động lực tế bào trong các mô lympho chính.",{"EN":2481,"VI":2482},"The somatic generation of immune recognition","Sự hình thành soma của nhận diện miễn dịch",{"VOID":2484},"14978855",{"VOID":2486},"10.1002\u002Feji.1830010102",[31],[30],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Feji.1830010102",[2491],{"id":2492,"sortIndex":32,"researcher":28,"roles":2493,"affiliations":2494,"properties":2501,"displayName":2503,"givenName":28,"familyName":28},"7c0fed40-0fb2-46dd-9cf9-32ac9c3e81a1",[],[2495],{"id":2225,"sortIndex":32,"affiliation":2496,"properties":28},{"id":2225,"createTime":28,"updateTime":28,"relativeEntities":2497,"slug":28,"properties":2498,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2500,"statistic":28},[],{"title":2499},{"VI":2230},[],{"title":2502,"openalex":2504},{"EN":2503},"N. 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M., 1968, Differentiation and Immunology, 85, 10.1016\u002FB978-1-4831-9873-6.50010-0",{"doi":2823},"10.1016\u002FB978-1-4831-9873-6.50010-0",{"id":2825,"createTime":2826,"updateTime":2827,"relativeEntities":2828,"slug":2829,"properties":2830,"entityType":1059,"verifyStatus":26,"verifyTime":2847,"verifyNote":1060,"languages":2848,"translateLanguages":2849,"viewCount":32,"primaryUrl":2850,"fullTextUrl":28,"authors":2851,"publicationType":1099,"publisherRelationship":2905,"citationCount":2958,"citationInfo":2959,"publishDate":1519,"publishYear":1517,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":2961,"openAccess":28,"references":2962,"isForceReanalyzing":1235},"d64f480c-b424-4472-90ad-5133fbe46a79","2024-12-01T13:33:30.981+00:00","2025-02-22T21:16:36.849+00:00",[],"The-rapid-isolation-of-clonable-antigen-specific-T-lymphocyte-lines-capable-of-mediating-autoimmune-encephalomyelitis",{"mag":2831,"keywords":2833,"openalex":2835,"abstract":2837,"title":2840,"pm":2843,"doi":2845},{"VOID":2832},"2127534922",{"VI":2834},"T lymphocytes, autoimmune encephalomyelitis, antigen specificity",{"VOID":2836},"W2127534922",{"EN":2838,"VI":2839},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>The isolation and propagation of functional antigen‐specific lines of T lymphoblasts is described. These lines were found to recognize foreign or self antigens in association with accessory cells of syngeneic major histocompatibility complex genotype. Intravenous inoculation of a T cell reactive only against myelin basic protein led to development of clinical paralysis in syngeneic rats. Thus, it is possible to study biological function as well as antigen specificity using T cell lines.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Việc cách ly và phát triển các dòng T lymphoblast đặc hiệu kháng nguyên có chức năng được mô tả. Những dòng tế bào này được phát hiện có khả năng nhận diện các kháng nguyên ngoại lai hoặc tự thân liên quan đến các tế bào hỗ trợ của kiểu gen phức hợp di truyền chính tương đồng. Việc tiêm tĩnh mạch một tế bào T chỉ phản ứng với protein cơ bản myelin đã dẫn đến sự phát triển tình trạng liệt lâm sàng ở chuột đồng gene tương đồng. Do đó, có thể nghiên cứu chức năng sinh học cũng như đặc hiệu kháng nguyên bằng cách sử dụng các dòng tế bào T.",{"EN":2841,"VI":2842},"The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis","Sự cách ly nhanh chóng các dòng tế bào T lympho đặc hiệu kháng nguyên có khả năng trung gian cho bệnh viêm não và tủy tự miễn",{"VOID":2844},"6165588",{"VOID":2846},"10.1002\u002Feji.1830110307","2024-12-01T13:33:30.980+00:00",[31],[30],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Feji.1830110307",[2852,2869,2888],{"id":2853,"sortIndex":32,"researcher":28,"roles":2854,"affiliations":2855,"properties":2864,"displayName":2866,"givenName":28,"familyName":28},"324ea967-918f-4108-9a8f-70e5745c30ce",[],[2856],{"id":2857,"sortIndex":32,"affiliation":2858,"properties":28},"be97d436-f132-421e-ba70-ff488891ce5c",{"id":2857,"createTime":28,"updateTime":28,"relativeEntities":2859,"slug":28,"properties":2860,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2863,"statistic":28},[],{"title":2861},{"EN":2862},"Department of Cell Biology, The Weizmann Institute of Science, Rehovot",[],{"title":2865,"openalex":2867},{"EN":2866},"Avraham Ben‐Nun",{"VOID":2868},"A5042549087",{"id":2870,"sortIndex":40,"researcher":28,"roles":2871,"affiliations":2872,"properties":2881,"displayName":2885,"givenName":28,"familyName":28},"f003141d-2d27-4c75-b71c-25342fa312de",[],[2873],{"id":2874,"sortIndex":32,"affiliation":2875,"properties":28},"212237a6-9870-4098-9eb5-d7ba124038de",{"id":2874,"createTime":28,"updateTime":28,"relativeEntities":2876,"slug":28,"properties":2877,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2880,"statistic":28},[],{"title":2878},{"EN":2879},"Max-Planck-Institüt für Immunbiologie, Freiburg",[],{"orcid":2882,"title":2884,"openalex":2886},{"VOID":2883},"https:\u002F\u002Forcid.org\u002F0000-0002-8669-2954",{"EN":2885},"Hartmut Wekerle",{"VOID":2887},"A5082308405",{"id":2889,"sortIndex":123,"researcher":28,"roles":2890,"affiliations":2891,"properties":2898,"displayName":2902,"givenName":28,"familyName":28},"ad355a19-4b34-44f9-901c-6e2ea2acb208",[],[2892],{"id":2857,"sortIndex":32,"affiliation":2893,"properties":28},{"id":2857,"createTime":28,"updateTime":28,"relativeEntities":2894,"slug":28,"properties":2895,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2897,"statistic":28},[],{"title":2896},{"EN":2862},[],{"orcid":2899,"title":2901,"openalex":2903},{"VOID":2900},"https:\u002F\u002Forcid.org\u002F0000-0002-3906-6993",{"EN":2902},"Irun R. 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W., 1977, J. Immunol., 119, 131, 10.4049\u002Fjimmunol.119.1.131",{"doi":2975},"10.4049\u002Fjimmunol.119.1.131",{"id":28,"text":2977,"url":28,"identifiers":2978},"10.1038\u002F268154a0",{"doi":2977},{"id":28,"text":2980,"url":28,"identifiers":2981},"10.1038\u002F283581a0",{"doi":2980},{"id":28,"text":2983,"url":28,"identifiers":2984},"10.1002\u002Feji.1830090804",{"doi":2983},{"id":28,"text":2986,"url":28,"identifiers":2987},"10.1159\u002F000230217",{"doi":2986},{"id":28,"text":2989,"url":28,"identifiers":2990},"Wekerle H., 1978, Genetic Control of Autoimmune Disease, 415",{},{"id":28,"text":2992,"url":28,"identifiers":2993},"Rosenberg S. A., 1978, J. Immunol., 121, 1946, 10.4049\u002Fjimmunol.121.5.1946",{"doi":2994},"10.4049\u002Fjimmunol.121.5.1946",{"id":28,"text":2996,"url":28,"identifiers":2997},"10.1098\u002Frspb.1974.0083",{"doi":2996},{"id":28,"text":2999,"url":28,"identifiers":3000},"10.1111\u002Fj.1600-065X.1978.tb00405.x",{"doi":2999},{"id":28,"text":3002,"url":28,"identifiers":3003},"10.1084\u002Fjem.145.5.1237",{"doi":3002},{"id":28,"text":3005,"url":28,"identifiers":3006},"10.1111\u002Fj.1365-3083.1978.tb00522.x",{"doi":3005},{"id":28,"text":3008,"url":28,"identifiers":3009},"10.1002\u002Feji.1830080212",{"doi":3008},{"id":28,"text":3011,"url":28,"identifiers":3012},"10.1002\u002Feji.1830030312",{"doi":3011},{"id":28,"text":3014,"url":28,"identifiers":3015},"10.1016\u002F0008-8749(75)90184-7",{"doi":3014},{"id":3017,"createTime":3018,"updateTime":3019,"relativeEntities":3020,"slug":3021,"properties":3022,"entityType":1059,"verifyStatus":26,"verifyTime":3018,"verifyNote":1060,"languages":3039,"translateLanguages":3040,"viewCount":32,"primaryUrl":3041,"fullTextUrl":28,"authors":3042,"publicationType":1099,"publisherRelationship":3221,"citationCount":3276,"citationInfo":3277,"publishDate":3280,"publishYear":3278,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":3281,"openAccess":28,"references":3282,"isForceReanalyzing":1235},"2aa09d09-c4d1-45d1-aa13-3b68f077f886","2024-09-04T14:27:03.866+00:00","2024-12-24T09:16:30.986+00:00",[],"CD4-sup-sup-CD25-sup-sup-regulatory-T-cells-suppress-tumor-immunity-but-are-sensitive-to-cyclophosphamide-which-allows-immunotherapy-of-established-tumors-to-be-curative",{"mag":3023,"keywords":3025,"openalex":3027,"abstract":3029,"title":3032,"pm":3035,"doi":3037},{"VOID":3024},"2038381158",{"VI":3026},"CD4\u003Csup>+\u003C\u002Fsup>CD25\u003Csup>+\u003C\u002Fsup>, regulatory T cells, immunotherapy, tumor immunity, cyclophosphamide, immune tolerance, rat colon carcinoma",{"VOID":3028},"W2038381158",{"EN":3030,"VI":3031},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>We investigated the mechanisms of immune tolerance raised by tumors by comparing immunogenic and tolerogenic tumor cell clones isolated from a rat colon carcinoma. When injected into syngeneichosts, the immunogenic REGb cells yield tumors that are rejected, while the tolerogenic PROb cells yield progressive tumors and inhibit the regression of REGb tumors. We show here that PROb tumor volume is correlated with an expansion of CD4\u003Cjats:sup>+\u003C\u002Fjats:sup>CD25\u003Cjats:sup>+\u003C\u002Fjats:sup> regulatory T lymphocytes in lymphoid tissues. These cells delay \u003Cjats:italic>in vivo\u003C\u002Fjats:italic> the rejection of REGb tumors and inhibit \u003Cjats:italic>in vitro\u003C\u002Fjats:italic> T cell‐mediated immune responses against REGb cells through a mechanism that requires cell contact between effector and regulatory T cells and involves TGF‐β. While total T cells fromPROb tumor‐bearing rats yield no apparent anti‐tumor immune response, depletion of CD25\u003Cjats:sup>+\u003C\u002Fjats:sup> T cells restores this reactivity. A single administration of cyclophosphamide depletes CD4\u003Cjats:sup>+\u003C\u002Fjats:sup>CD25\u003Cjats:sup>+\u003C\u002Fjats:sup> T cells in PROb tumor‐bearing animals, delays the growth of PROb tumors, and cures rats bearing established PROb tumors when followed by an immunotherapy which has no curative effect when administered alone. These results demonstrate the role of CD4\u003Cjats:sup>+\u003C\u002Fjats:sup>CD25\u003Cjats:sup>+\u003C\u002Fjats:sup> regulatory T cells in tumor‐induced immune tolerance and the interest of regulatory T cell depletion to sensitize established tumors to immunotherapy.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Chúng tôi đã nghiên cứu các cơ chế dung nạp miễn dịch do khối u gây ra bằng cách so sánh các dòng tế bào khối u có khả năng sinh miễn dịch và dung nạp miễn dịch được tách ra từ ung thư đại tràng chuột. Khi được tiêm vào vật chủ cùng loài, các tế bào REGb sinh miễn dịch tạo ra khối u bị đào thải, trong khi các tế bào PROb dung nạp miễn dịch tạo ra khối u phát triển và ức chế sự thoái triển của các khối u REGb. Chúng tôi cho thấy rằng thể tích khối u PROb có tương quan với sự gia tăng của các tế bào T điều hòa CD4\u003Cjats:sup>+\u003C\u002Fjats:sup>CD25\u003Cjats:sup>+\u003C\u002Fjats:sup> trong các mô bạch huyết. Những tế bào này làm chậm lại sự đào thải \u003Cjats:italic>in vivo\u003C\u002Fjats:italic> các khối u REGb và ức chế \u003Cjats:italic>in vitro\u003C\u002Fjats:italic> các phản ứng miễn dịch do tế bào T chống lại các tế bào REGb thông qua một cơ chế yêu cầu tiếp xúc giữa các tế bào T hiệu lực và tế bào T điều hòa và có sự tham gia của TGF-β. Trong khi các tế bào T tổng từ chuột mang khối u PROb không tạo ra phản ứng miễn dịch kháng khối u rõ ràng, việc loại bỏ các tế bào T CD25\u003Cjats:sup>+\u003C\u002Fjats:sup> khôi phục phản ứng này. Một lần sử dụng cyclophosphamide làm suy giảm các tế bào T CD4\u003Cjats:sup>+\u003C\u002Fjats:sup>CD25\u003Cjats:sup>+\u003C\u002Fjats:sup> trong động vật mang khối u PROb, trì hoãn sự phát triển của khối u PROb, và chữa khỏi chuột mang khối u PROb hiện hành khi được theo sau bằng liệu pháp miễn dịch mà không có hiệu quả chữa trị khi được áp dụng đơn lẻ. 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The cells found in freshly isolated synovial fluid constitutively expressed IL6 mRNA. The synovial tissues obtained by joint biopsy were also found to produce IL6 \u003Cjats:italic>in vitro.\u003C\u002Fjats:italic> Immunohistochemical analysis demonstrated that CD2\u003Cjats:sup>+\u003C\u002Fjats:sup> T cells as well as CD20\u003Cjats:sup>+\u003C\u002Fjats:sup> blastoid B cells in the synovial tissues produce IL6. The data indicate that IL6 is generated constitutively in RA and its overproduction may explain the local as well as the generalized symptoms of RA, since IL6 can function as B cell growth and differentiation factor as well as hepatocyte‐stimulating factor.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Các mức interleukin 6 (IL 6\u002FFaktor kích thích tế bào B-2) cao đã được phát hiện trong dịch khớp từ các khớp của bệnh nhân viêm khớp dạng thấp (RA) đang hoạt động. 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