[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_f9bea3c4-c8cf-4386-8011-7d053d00716f":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:f9bea3c4-c8cf-4386-8011-7d053d00716f,\"}":145},{"code":4,"data":5,"meta":22},"SUCCESS",{"id":6,"createTime":7,"updateTime":8,"relativeEntities":9,"slug":10,"properties":11,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":24,"manageAffiliations":43,"indexDatabases":59,"url":22,"thumbnailPath":22,"statistic":97,"gsStatistic":22,"type":144,"analyzePriority":22},"f9bea3c4-c8cf-4386-8011-7d053d00716f","2024-04-09T02:54:59.120+00:00","2025-11-21T09:57:53.345+00:00",[],"European-Journal-of-Clinical-Microbiology-and-Infectious-Diseases",{"eissn":12,"issn":14,"title":16,"url":18},{"VOID":13},"09349723",{"VOID":15},"14354373",{"EN":17},"European Journal of Clinical Microbiology and Infectious Diseases",{"VOID":19},"https:\u002F\u002Flink.springer.com\u002Fjournal\u002F10096","PUBLISHER","PENDING",null,0,[25,31,37],{"id":26,"createTime":22,"updateTime":22,"relativeEntities":27,"label":28,"description":30,"parentId":22,"standard":22,"scholarHubFieldId":22},"bc5dfa48-b254-4628-b6ec-dad0ef23590b",[],{"EN":29},"Microbiology (medical)",{},{"id":32,"createTime":22,"updateTime":22,"relativeEntities":33,"label":34,"description":36,"parentId":22,"standard":22,"scholarHubFieldId":22},"837c26ad-ce88-445d-9621-a6d173c82561",[],{"EN":35},"Infectious Diseases",{},{"id":38,"createTime":22,"updateTime":22,"relativeEntities":39,"label":40,"description":42,"parentId":22,"standard":22,"scholarHubFieldId":22},"0254e3e5-c28d-4a33-83da-81bc94d29ffd",[],{"EN":41},"Medicine (miscellaneous)",{},[44,52],{"id":45,"createTime":22,"updateTime":22,"relativeEntities":46,"slug":22,"properties":47,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":50,"statistic":22},"6b6d67d8-1887-4ca8-86c5-a38f66f10928",[],{"title":48},{"EN":49},"Springer Verlag",[51],"9a7c7208-b28a-42c2-a634-5a7f90eee3ab",{"id":53,"createTime":22,"updateTime":22,"relativeEntities":54,"slug":22,"properties":55,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":58,"statistic":22},"26a19206-5cad-4456-bb2f-49abd254fbc6",[],{"title":56},{"EN":57},"SPRINGER",[],[60,79],{"id":61,"indexDatabase":62,"url":72,"indexYears":73,"academicFieldIds":74,"indexDatabaseRanking":78},"8bd46d91-e824-413d-b3c5-a57f5c64e342",{"id":63,"createTime":22,"updateTime":22,"relativeEntities":64,"label":65,"description":67,"key":69,"publicationTags":70,"standard":22},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9",[],{"EN":66,"VI":66},"Scopus - Elsevier",{"EN":66,"VI":68},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[71],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F19700","1988-2025",[75,76,77],"6054771f-c7fe-4028-b3af-04deb025c427","e89cebf4-fecf-4b74-8ab4-88fca891e4c2","1a7c8bc3-0575-4f8d-b22c-aec346a0168a","SCOPUS__Q1",{"id":80,"indexDatabase":81,"url":93,"indexYears":22,"academicFieldIds":94,"indexDatabaseRanking":22},"e2ff8de6-87ec-4cdf-8fad-5f0f0193bff1",{"id":82,"createTime":22,"updateTime":22,"relativeEntities":83,"label":84,"description":86,"key":89,"publicationTags":90,"standard":22},"a4921856-b128-4d9f-8f1f-e80813d3bbd4",[],{"EN":85,"VI":85},"ISI\u002FSCIE - Science Citation Index Expanded",{"EN":87,"VI":88},"SCIE database","Cơ sở dữ liệu SCIE","scie",[91,92],"SCIE","ISI","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=0934-9723",[95,96],"a2123f74-a835-4ccb-bfa4-b05c84c377d0","53866f02-5006-4f8f-a807-ec8cf950fc52",{"impactFactor":23,"impactFactorByYear":98,"i10Index":23,"i10IndexLast5Year":23,"totalPublication":100,"totalPublicationByYear":101,"totalCitation":136,"totalCitationByYear":137,"totalCitationPerPublication":23,"totalCitationPerPublicationByYear":141,"hindexLast5Year":138,"hindex":138},{"1989":99,"2014":23,"2021":23},0.01,4843,{"1982":102,"1983":103,"1984":104,"1985":105,"1986":106,"1987":107,"1988":108,"1989":107,"1990":109,"1991":110,"1992":111,"1993":112,"1994":113,"1995":114,"1996":111,"1997":115,"1998":111,"1999":115,"2000":116,"2001":117,"2002":118,"2003":119,"2004":120,"2005":121,"2006":122,"2007":123,"2008":124,"2009":118,"2010":125,"2011":126,"2012":127,"2013":128,"2014":129,"2015":130,"2016":131,"2017":130,"2018":132,"2019":127,"2020":133,"2021":112,"2022":134,"2023":135,"2024":102},40,65,88,83,92,118,116,111,117,124,131,123,139,102,98,110,71,105,91,79,87,86,140,155,184,156,106,144,130,177,134,164,76,104,14,{"1987":138,"2012":139,"2019":140},2,9,3,{"1987":142,"2012":143,"2019":142},0.02,0.06,"JOURNAL",{"meta":146,"data":148},{"total":147},"6574",[149,279,483,821,996,1167,1386,1558,1815,1914],{"id":150,"createTime":151,"updateTime":152,"relativeEntities":153,"slug":154,"properties":155,"entityType":165,"verifyStatus":166,"verifyTime":167,"verifyNote":168,"languages":22,"translateLanguages":169,"viewCount":23,"primaryUrl":171,"fullTextUrl":22,"authors":172,"publicationType":218,"publisherRelationship":219,"citationCount":22,"citationInfo":22,"publishDate":275,"publishYear":276,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":277,"openAccess":22,"references":22,"isForceReanalyzing":278},"703f9217-f5b1-4af9-8e0e-cb28e54f069d","2023-12-31T04:29:04.616+00:00","2026-09-11T02:21:44.060+00:00",[],"Western-blot-analysis-of-the-antibody-response-in-patients-withListeria-monocytogenes-meningitis-and-septicemia",{"abstract":156,"title":158,"references":161,"doi":163},{"EN":157},"The antibody response in patients withListeria monocytogenes septicemia and\u002For meningitis was investigated using Western blot analysis (WBA). Protein antigen preparations were produced from two strains ofListeria monocytogenes, representing serogroup 1 and 4, by sonication and differential centrifugation. IgG antibodies from 8 (50 %) of 16 patients with culture verified septicemia and\u002For meningitis due toListeria monocytogenes reacted with a 93 kDa antigen from serogroup 1, in contrast to IgG antibodies from only 1 (2 %) of 51 controls; these controls represented 21 patients with infections caused by other bacteria and 30 apparently healthy blood donors. Furthermore, IgM antibodies from 3 (19 %) of the patients with listeric infections bound to a 106 kDa protein antigen in contrast to none of the controls. In 3 (33 %) of 9 patients from whom acute and convalescence serum were available, the patients responded by producing antibodies against new protein antigens. Current methods used in routine serological investigations, i.e. complement fixation and O-agglutination tests, were positive in only 4 (24 %) of the 16 patients with listeriosis, The results point to the possibility of designing new immunoassays for detection of septicemia and meningitis caused byListeria monocytogenes.",{"EN":159,"VI":160},"Western blot analysis of the antibody response in patients withListeria monocytogenes meningitis and septicemia","Phân tích Western blot về đáp ứng kháng thể ở bệnh nhân viêm màng não và nhiễm trùng huyết do Listeria monocytogenes",{"VOID":162},"Nieman RE, Lorber B Listeriosis in adults: a changing pattern. Report of eight cases and review of the literature, 1968–1978. Reviews of Infectious Diseases 1980, 2: 207–227.\nSchwartz B, Hexter D, Broome CV, Higtower AW, Hirschhorn RB, Porter JD, Hayes PS, Bibb WF, Lorber B, Faris DG Investigation of an outbreak of listeriosis: new hypotheses for the etiology of epidemicListeria monocytogenes infections. Journal of Infectious Diseases 1989, 159: 680–685.\nMackaness GB The immunological basis of acquired cellular resistance. Journal of Experimental Medicine 1964, 120: 105–120.\nMackaness GB The influence of immunologically committed lymphoid cells on macrophage activity in vivo. Journal of Experimental Medicine 1969, 120: 93–103.\nMitsuyama MK, Takeya K, Nomoto K, Shimotori S Three phases of phagocyte contribution to resistance againstListeria monocytogenes. Journal of General Microbiology 1978, 106: 165–171.\nMiki K, Mackaness GB The passive transfer of acquired resistance toListeria monocytogenes. Journal of Experimental Medicine 1964, 129: 973–992.\nTatsukawa K, Mitsuyama M, Takeya K, Nomoto K Differing contribution of polymorphonuclear cells and macrophages to protection of mice againstListeria monocytogenes andPseudomonas aeruginosa. Journal of General Microbiology 1979, 115: 161–166.\nGray ML, Killinger AH Listeria monocytogenes and listeric infections. Bacteriological Reviews 1966, 30: 309–382.\nSeeliger HPR Listeriosis. Hafner Publishing, New York, 1961.\nGellin BG, Broome CV Listeriosis. Journal of the American Medical Association 1989, 261: 1313–1320.\nNeter E, Anzai H, Gorzynski EA Identification of an antigen common toListeria monocytogenes and other bacteria. Proceedings of the Society for Experimental and Biological Medicine 1960, 105: 131–134.\nWinblad S Considerations on the serology of human listeriosis in Sweden. Acta Pathologica et Microbiologica Scandinavica 1962, Supplement 154: 244–247.\nWinblad S Studies of antibodies in human listeriosis. I: Antibodies in cases of bacteriologically verified human listeriosis. Acta Pathologica et Microbiologica Scandinavica 1963, 58: 123–132.\nWinblad S, Borglin NE Studies of antibodies in human listeriosis. II: Antibody titres in healthy people and patients of different categories. Acta Pathologica et Microbiologica Scandinavica 1963, 58: 133–144.\nLarsson S Human listeriosis in Sweden. Thesis, Lund University, Sweden 1978.\nChakraborty T, Boebel W Recent developments in the study of virulence inListeria monocytogenes. Current Topics in Microbiology and Immunology 1988, 4: 41–58.",{"VOID":164},"10.1007\u002FBF01964267","PUBLICATION","VERIFIED","2024-12-23T12:45:13.808+00:00","Auto Verify",[170],"VI","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002FBF01964267",[173,189,205],{"id":174,"sortIndex":23,"researcher":22,"roles":175,"affiliations":177,"properties":186,"displayName":188,"givenName":22,"familyName":22},"1d445353-90dc-4061-b254-8359be2202fe",[176],"AUTHOR",[178],{"id":179,"sortIndex":23,"affiliation":180,"properties":22},"85059a91-2e8d-40c4-b06f-6d526bbf5156",{"id":179,"createTime":22,"updateTime":22,"relativeEntities":181,"slug":22,"properties":182,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":185,"statistic":22},[],{"title":183},{"VI":184},"Department of Clinical Microbiology, Herlev Amtssygehus, Herlev, Denmark",[],{"title":187},{"VI":188},"J. Renneberg",{"id":190,"sortIndex":191,"researcher":22,"roles":192,"affiliations":193,"properties":202,"displayName":204,"givenName":22,"familyName":22},"035101e5-0a4f-44a9-ab88-9558a97bf017",1,[176],[194],{"id":195,"sortIndex":23,"affiliation":196,"properties":22},"0c66a020-3196-4dcc-a527-b74c9de8170a",{"id":195,"createTime":22,"updateTime":22,"relativeEntities":197,"slug":22,"properties":198,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":201,"statistic":22},[],{"title":199},{"VI":200},"Department of Medical Microbiology, University of Lund, Malmö General Hospital, Malmö, Sweden",[],{"title":203},{"VI":204},"K. Persson",{"id":206,"sortIndex":138,"researcher":22,"roles":207,"affiliations":208,"properties":215,"displayName":217,"givenName":22,"familyName":22},"c4053016-25d5-4975-b759-be5fc991e3a9",[176],[209],{"id":195,"sortIndex":23,"affiliation":210,"properties":22},{"id":195,"createTime":22,"updateTime":22,"relativeEntities":211,"slug":22,"properties":212,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":214,"statistic":22},[],{"title":213},{"VI":200},[],{"title":216},{"VI":217},"P. Christensen","ARTICLE",{"url":171,"publisher":220,"properties":270},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":221,"slug":10,"properties":222,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":226,"manageAffiliations":239,"indexDatabases":250,"url":22,"thumbnailPath":22,"statistic":265,"gsStatistic":22,"type":144,"analyzePriority":22},[],{"issn":223,"title":224,"eissn":225},{"VOID":15},{"EN":17},{"VOID":13},[227,231,235],{"id":26,"createTime":22,"updateTime":22,"relativeEntities":228,"label":229,"description":230,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":29},{},{"id":32,"createTime":22,"updateTime":22,"relativeEntities":232,"label":233,"description":234,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":35},{},{"id":38,"createTime":22,"updateTime":22,"relativeEntities":236,"label":237,"description":238,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":41},{},[240,245],{"id":45,"createTime":22,"updateTime":22,"relativeEntities":241,"slug":22,"properties":242,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":244,"statistic":22},[],{"title":243},{"EN":49},[51],{"id":53,"createTime":22,"updateTime":22,"relativeEntities":246,"slug":22,"properties":247,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":249,"statistic":22},[],{"title":248},{"EN":57},[],[251,258],{"id":61,"indexDatabase":252,"url":72,"indexYears":73,"academicFieldIds":257,"indexDatabaseRanking":78},{"id":63,"createTime":22,"updateTime":22,"relativeEntities":253,"label":254,"description":255,"key":69,"publicationTags":256,"standard":22},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75,76,77],{"id":80,"indexDatabase":259,"url":93,"indexYears":22,"academicFieldIds":264,"indexDatabaseRanking":22},{"id":82,"createTime":22,"updateTime":22,"relativeEntities":260,"label":261,"description":262,"key":89,"publicationTags":263,"standard":22},[],{"EN":85,"VI":85},{"EN":87,"VI":88},[91,92],[95,96],{"impactFactor":23,"impactFactorByYear":266,"i10Index":23,"i10IndexLast5Year":23,"totalPublication":100,"totalPublicationByYear":267,"totalCitation":136,"totalCitationByYear":268,"totalCitationPerPublication":23,"totalCitationPerPublicationByYear":269,"hindexLast5Year":138,"hindex":138},{"1989":99,"2014":23,"2021":23},{"1982":102,"1983":103,"1984":104,"1985":105,"1986":106,"1987":107,"1988":108,"1989":107,"1990":109,"1991":110,"1992":111,"1993":112,"1994":113,"1995":114,"1996":111,"1997":115,"1998":111,"1999":115,"2000":116,"2001":117,"2002":118,"2003":119,"2004":120,"2005":121,"2006":122,"2007":123,"2008":124,"2009":118,"2010":125,"2011":126,"2012":127,"2013":128,"2014":129,"2015":130,"2016":131,"2017":130,"2018":132,"2019":127,"2020":133,"2021":112,"2022":134,"2023":135,"2024":102},{"1987":138,"2012":139,"2019":140},{"1987":142,"2012":143,"2019":142},{"pages":271,"volume":273},{"VOID":272},"659-663",{"VOID":274},"9","1990-09-01",1990,[91,78],false,{"id":280,"createTime":281,"updateTime":282,"relativeEntities":283,"slug":284,"properties":285,"entityType":165,"verifyStatus":166,"verifyTime":295,"verifyNote":168,"languages":22,"translateLanguages":296,"viewCount":23,"primaryUrl":297,"fullTextUrl":22,"authors":298,"publicationType":218,"publisherRelationship":424,"citationCount":22,"citationInfo":22,"publishDate":480,"publishYear":481,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":482,"openAccess":22,"references":22,"isForceReanalyzing":278},"00bb90cf-1d1d-4e93-9982-a6b78b2899f5","2024-01-28T06:19:40.500+00:00","2026-09-10T05:14:54.424+00:00",[],"Description-of-macrolide-resistant-and-potential-virulent-clones-of-Streptococcus-pyogenes-causing-asymptomatic-colonization-during-2000-2006-in-the-Lisbon-area",{"abstract":286,"title":288,"references":291,"doi":293},{"EN":287},"The asymptomatic oropharyngeal colonization rate by Streptococcus pyogenes was 10.7% in children (901 among 8,405 children 0–16 years old) and 3.3% in adults (37 among 1,126 households of children) in the Lisbon area during 2000–2006. Macrolide-resistant S. pyogenes from children (n = 149) was variable with time: 9.8–10.7% in 2000–2002, 28.1% in 2003, 19.6–2.7% in 2004–2005 and 14.6% in 2006. Eight lineages (97.3% of isolates) were identified based on at least 80% similarity of PFGE patterns, T types, emm types and multilocus sequence types (ST). The elevated frequency of macrolide resistance was associated with M phenotype lineages I (emm12\u002FST36) and V (emm4, emm75\u002FST39 and a novel emmstMrp6 type) and with one cMLSB lineage IV (emm28\u002FST52) known to be associated with upper respiratory tract and invasive infections. Significant associations (p \u003C 0.05) between emm type\u002Fvirulence genotype were found, such as emm1\u002FspeA\n                +\n                ssa\n                -, emm4\u002Fssa\n                +\n                prtF1\n                +, emm12\u002FspeA\n                -\n                ssa\n                -. The high prevalence (>20%) of speC, prtF1 or ssa was probably caused either by clonal dissemination (speC), or to horizontal gene transfer events (prtF1 and ssa). This report contributes to a better understanding of the molecular epidemiology and evolution of macrolide-resistant S. pyogenes causing symptom-free oropharyngeal colonization. These colonizing strains carry macrolide resistance and virulence genes capable of being transferred to other bacterial species sharing the same niche.",{"EN":289,"VI":290},"Description of macrolide-resistant and potential virulent clones of Streptococcus pyogenes causing asymptomatic colonization during 2000–2006 in the Lisbon area","Mô tả các dòng Streptococcus pyogenes kháng macrolide và có tiềm năng độc lực gây định cư không triệu chứng trong giai đoạn 2000–2006 tại khu vực Lisbon",{"VOID":292},"Cunningham MW (2000) Pathogenesis of Group A streptococcal infections. Clin Microbiol Rev 13:470–511\nPichichero ME, Marsocci SM, Murphy AML, Hoeger W, Green JL, Sorrento A (1999) Incidence of streptococcal carriers in private pediatric practice. Arch Pediatr Adolesc Med 153:624–628\nFazeli MR, Ghaemi E, Tabarraei A, Kaplan EL, Johnson DR, Vakili MA, Khodabakhshi B (2003) Group A streptococcal serotypes isolated from healthy schoolchildren in Iran. Eur J Clin Microbiol Infect Dis 22:475–478\nAguero J, Ortega-Mendi M, Eliecer MC, de Aledo AG, Calvo J, Vilória L, Mellado P, Pelayo T, Fernandez-Rodriguez A, Martinez-Martinez L (2008) Outbreak of invasive Group A streptococcal disease among children attending a day-care center. Pediatr Infect Dis J 27:602–604\nBisno AL, Gerber MA, Gwaltney JM Jr, Kaplan EL, Schwartz RH (2002) Practice guidelines for the diagnosis and management of Group A streptococcal pharyngitis. Clin Infect Dis 35:113–125\nFelmingham D, Farrell DJ, Reinert RR, Morrissey I (2004) Antibacterial resistance among children with community-acquired respiratory tract infections (PROTEKT 1999–2000). J Infect 48:39–55\nCreti R, Gherardi G, Imperi M, von Hunolstein C, Baldassarri L, Pataracchia M, Alfarone G, Cardona F, Dicuonzo G, Orefici G (2005) Association of Group A streptococcal emm types with virulence traits and macrolide-resistance genes is independent of the source of isolation. J Med Microbiol 54:913–917\nPires R, Rolo D, Gama-Norton L, Morais A, Lito L, Salgado MJ, Johansson C, Möllerberg G, Henriques-Normark B, Gonçalo-Marques J, Santos-Sanches I (2005) Group A streptococci from carriage and disease in Portugal: evolution of antimicrobial resistance and T antigenic types during 2000–2002. Microb Drug Resist 11:360–370\nChang H, Shen X, Fu Z, Liu L, Shen Y, Liu X, Yu S, Yao K, Zhao C, Yang Y (2010) Antibiotic resistance and molecular analysis of Streptococcus pyogenes isolated from healthy schoolchildren in China. Scand J Infect Dis 42:84–89\nSutcliffe J, Tait-Kamradt A, Wondrack L (1996) Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system. Antimicrob Agents Chemother 40:1817–1824\nSeppälä H, Skurnik M, Soini H, Roberts MC, Huovinen P (1998) A novel erythromycin resistance methylase gene (ermTR) in Streptococcus pyogenes. Antimicrob Agents Chemother 42:257–262\nMcCormick JK, Schlievert PM (2000) Toxins and superantigens of Group A streptococcci. In: Fischetti VA et al (eds) Gram-positive pathogens. American Society for Microbiology Press, Washington DC, USA, pp 43–52\nTalay SR, Valentin-Weigand P, Jerlström PG, Timmis KN, Chhatwal GS (1992) Fibronectin-binding protein of Streptococcus pyogenes: sequence of the binding domain involved in adherence of streptococci to epithelial cells. Infect Immun 60:3837–3844\nPires R, Rolo D, Mato R, de Almeida JF, Johansson C, Henriques-Normark B, Morais A, Brito-Avô A, Gonçalo-Marques J, Santos-Sanches I (2009) Resistance to bacitracin in Streptococcus pyogenes from oropharyngeal colonization and noninvasive infections in Portugal was caused by two clones of distinct virulence genotypes. FEMS Microbiol Lett 296:235–240\nClinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing, sixteenth informational supplement. CLSI document M100-S16. Wayne, PA: CLSI, 2006.\nSeppälä H, Nissinen A, Yu Q, Huovinen P (1993) Three different phenotypes of erythromycin-resistant Streptococcus pyogenes in Finland. J Antimicrob Chemother 32:885–891\nTenover FC, Arbeit RD, Goering RV, Mickelsen PA, Murray BE, Persing DH, Swaminathan B (1995) Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strains typing. J Clin Microbiol 33:2233–2239\nKlugman KP, Capper T, Widdowson CA, Koornhof HJ, Moser W (1998) Increased activity of 16-membered lactone ring macrolides against erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumoniae: characterization of South African isolates. J Antimicrob Chemother 42:729–734\nFigueira-Coelho J, Ramirez M, Salgado MJ, Melo-Cristino J (2004) Streptococcus agalactiae in a large Portuguese teaching hospital: antimicrobial susceptibility, serotype distribution, and clonal analysis of macrolide-resistant isolates. Microb Drug Resist 10:31–36\nIimura T, Kashiwagi Y, Endo M, Amano Y (2006) Prevalence and persistence of certain serologic types of Streptococcus pyogenes in metropolitan Tokyo. J Infect Chemother 12:53–62\nDe Melo MCN, Figueiredo AMS, Ferreira-Carvalho BT (2003) Antimicrobial susceptibility patterns and genomic diversity in strains of Streptococcus pyogenes isolated in 1978–1997 in different Brazilian cities. J Med Microbiol 52:251–258\nSilva-Costa C, Pinto FR, Ramirez M, Melo-Cristino J, Portuguese Surveillance Group for the Study of Respiratory Pathogens (2008) Decrease in macrolide resistance and clonal instability among Streptococcus pyogenes in Portugal. Clin Microbiol Infect 14:1152–1159\nBaldassarri L, Creti R, Imperi M, Recchia S, Pataracchia BM, Alfarone G, Orefici G (2007) Detection of genes encoding internalization-associated proteins in Streptococcus pyogenes isolates from patients with invasive diseases and asymptomatic carriers. J Clin Microbiol 45:1284–1287\nCreti R, Imperi M, Baldassarri L, Pataracchia M, Recchia S, Alfarone G, Orefici G (2007) emm types, virulence factors and antibiotic resistante of invasive S. pyogenes isolates from Italy: what has changed in 11 years? J Clin Microbiol 45:2249–2256\nFriães A, Ramirez M, Melo-Cristino J, the Portuguese Group for the Study of Streptococcal Infections (2007) A non-outbreak surveillance of Group A streptococci causing invasive disease in Portugal identified internationally disseminated clones among a genetically heterogeneous population. J Clin Microbiol 45:2044–2047\nTraverso F, Sparo M, Rubio V, Sáez Nieto JÁ (2010) Molecular characterization of Streptococcus pyogenes from invasive disease and streptococcal toxic shock syndrome episodes. Rev Argent Microbiol 42:41–45\nReinert RR, Rodloff AC, Halle E, Baer W, Beyreiss B, Seifert H, Wichelhaus TA, Maass M, Mehl M (2004) Antibacterial resistance of community-acquired respiratory tract pathogens recovered from patients in Germany and activity of the ketolide telithromycin: results from the PROTEKT surveillance study (1999–2000). Chemotherapy 50:143–151\nMcGregor KF, Spratt BG (2005) Identity and prevalence of multilocus sequence typing-defined clones of Group A streptococci within a hospital setting. J Clin Microbiol 43:1963–1967\nArdanuy C, Domenech A, Rolo D, Calatayud L, Tubau F, Ayats J, Martín R, Liñares J (2010) Molecular characterization of macrolide- and multidrug-resistant Streptococcus pyogenes isolated from adult patients in Barcelona, Spain (1993–2008). J Antimicrob Chemother 65:634–643\nSilva-Costa C, Ramirez M, Melo-Cristino J (2006) Identification of macrolide-resistant clones of Streptococcus pyogenes in Portugal. Clin Microbiol Infect 12:513–518\nMihaila-Amrouche L, Bouvet A, Loubinoux J (2004) Clonal spread of emm type 28 isolates of Streptococcus pyogenes that are multiresistant to antibiotics. J Clin Microbiol 42:3844–3846\nLittauer L, Caugant DA, Sangvik M, Høiby EA, Sundsfjord A, Simonsen GS, the Norwegian Macrolide Study Group (2006) Macrolide-resistant Streptococcus pyogenes in Norway: population structure and resistance determinants. Antimicrob Agents Chemother 50:1896–1899\nMalhotra-Kumar S, Wang S, Lammens C, Chapelle S, Goossens H (2003) Bacitracin-resistant clone of Streptococcus pyogenes isolated from pharyngitis patients in Belgium. J Clin Microbiol 41:5282–5284\nGrivea IN, Al-Lahham A, Katopodis GD, Syrogiannopoulos GA, Reinert RR (2006) Resistance to erythromycin and telithromycin in Streptococcus pyogenes isolates obtained between 1999 and 2002 from Greek children with tonsillopharyngitis: phenotypic and genotypic analysis. Antimicrob Agents Chemother 50:256–261\nMolinari G, Talay SR, Valentin-Weigand P, Rohde M, Chhatwal GS (1997) The fibronectin-binding protein of Streptococcus pyogenes, SfbI, is involved in the internalization of Group A streptococci by epithelial cells. Infect Immun 65:1357–1363\nCoenen S, Ferech M, Malhotra-Kumar S, Hendrickx E, Suetens C, Goossens H (2006) European Surveillance of Antimicrobial Consumption (ESAC): outpatient macrolide, lincosamide and streptogramin (MLS) use in Europe. J Antimicrob Chemother 58:418–422\nMalhotra-Kumar S, Lammens C, Coenen S, Herck KV, Goosens H (2007) Effect of azithromycin and clarithromycin therapy on pharyngeal carriage of macrolide-resistant streptococci in healthy volunteers: a randomised, double-blind, placebo-controlled study. Lancet 369:482–490",{"VOID":294},"10.1007\u002Fs10096-011-1384-x","2025-01-11T13:38:51.506+00:00",[170],"https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs10096-011-1384-x",[299,314,336,351,364,380,394,410],{"id":300,"sortIndex":23,"researcher":22,"roles":301,"affiliations":302,"properties":311,"displayName":313,"givenName":22,"familyName":22},"8bd82e4c-4507-4c41-91dc-ab78ad1dc0c2",[176],[303],{"id":304,"sortIndex":23,"affiliation":305,"properties":22},"a16f6c17-c85a-4fc0-8f7d-e4f7f92cd10b",{"id":304,"createTime":22,"updateTime":22,"relativeEntities":306,"slug":22,"properties":307,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":310,"statistic":22},[],{"title":308},{"VI":309},"Centro de Recursos Microbiológicos, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal",[],{"title":312},{"VI":313},"R. Pires",{"id":315,"sortIndex":191,"researcher":22,"roles":316,"affiliations":317,"properties":333,"displayName":335,"givenName":22,"familyName":22},"c3ec6076-df65-4b63-bab4-42a4ea05f24c",[176],[318,324],{"id":304,"sortIndex":23,"affiliation":319,"properties":22},{"id":304,"createTime":22,"updateTime":22,"relativeEntities":320,"slug":22,"properties":321,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":323,"statistic":22},[],{"title":322},{"VI":309},[],{"id":325,"sortIndex":191,"affiliation":326,"properties":332},"9c746684-ee3e-43e1-8c36-9f2a2af3fddd",{"id":325,"createTime":22,"updateTime":22,"relativeEntities":327,"slug":22,"properties":328,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":331,"statistic":22},[],{"title":329},{"VI":330},"Microbiology Department, Institut d’Investigació Biomèdica de Bellvitge, Hospital Universitari de Bellvitge, Barcelona, Spain",[],{},{"title":334},{"VI":335},"D. Rolo",{"id":337,"sortIndex":138,"researcher":22,"roles":338,"affiliations":339,"properties":348,"displayName":350,"givenName":22,"familyName":22},"70c468ec-f8fa-41cc-a977-eaec4a4d0503",[176],[340],{"id":341,"sortIndex":23,"affiliation":342,"properties":22},"a01696f0-5993-488a-a5a7-ff6db414f199",{"id":341,"createTime":22,"updateTime":22,"relativeEntities":343,"slug":22,"properties":344,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":347,"statistic":22},[],{"title":345},{"VI":346},"Centro de Saúde de Oeiras, Oeiras, Portugal",[],{"title":349},{"VI":350},"A. Morais",{"id":352,"sortIndex":140,"researcher":22,"roles":353,"affiliations":354,"properties":361,"displayName":363,"givenName":22,"familyName":22},"f1f94519-b65f-4069-a463-9a2538c45dd2",[176],[355],{"id":341,"sortIndex":23,"affiliation":356,"properties":22},{"id":341,"createTime":22,"updateTime":22,"relativeEntities":357,"slug":22,"properties":358,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":360,"statistic":22},[],{"title":359},{"VI":346},[],{"title":362},{"VI":363},"A. Brito-Avô",{"id":365,"sortIndex":366,"researcher":22,"roles":367,"affiliations":368,"properties":377,"displayName":379,"givenName":22,"familyName":22},"3f173c07-b4e1-48ce-bedc-024acff14544",4,[176],[369],{"id":370,"sortIndex":23,"affiliation":371,"properties":22},"c54d5593-e0b4-42eb-87aa-ff4ca408ac9e",{"id":370,"createTime":22,"updateTime":22,"relativeEntities":372,"slug":22,"properties":373,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":376,"statistic":22},[],{"title":374},{"VI":375},"Swedish Institute for Infectious Disease Control, Solna, Sweden",[],{"title":378},{"VI":379},"C. Johansson",{"id":381,"sortIndex":382,"researcher":22,"roles":383,"affiliations":384,"properties":391,"displayName":393,"givenName":22,"familyName":22},"116d76e6-c02e-411f-97d0-6f2d1a3b53f1",5,[176],[385],{"id":370,"sortIndex":23,"affiliation":386,"properties":22},{"id":370,"createTime":22,"updateTime":22,"relativeEntities":387,"slug":22,"properties":388,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":390,"statistic":22},[],{"title":389},{"VI":375},[],{"title":392},{"VI":393},"B. Henriques-Normark",{"id":395,"sortIndex":396,"researcher":22,"roles":397,"affiliations":398,"properties":407,"displayName":409,"givenName":22,"familyName":22},"5fef0edb-6c33-4de7-88c0-281e1bad7429",6,[176],[399],{"id":400,"sortIndex":23,"affiliation":401,"properties":22},"e00f319f-a13e-4660-8238-05581e35e2be",{"id":400,"createTime":22,"updateTime":22,"relativeEntities":402,"slug":22,"properties":403,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":406,"statistic":22},[],{"title":404},{"VI":405},"Hospital de Santa Maria, Lisbon, Portugal",[],{"title":408},{"VI":409},"J. Gonçalo-Marques",{"id":411,"sortIndex":412,"researcher":22,"roles":413,"affiliations":414,"properties":421,"displayName":423,"givenName":22,"familyName":22},"4751de56-47a3-49fc-a5ab-cd1c9497ff67",7,[176],[415],{"id":304,"sortIndex":23,"affiliation":416,"properties":22},{"id":304,"createTime":22,"updateTime":22,"relativeEntities":417,"slug":22,"properties":418,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":420,"statistic":22},[],{"title":419},{"VI":309},[],{"title":422},{"VI":423},"I. Santos-Sanches",{"url":297,"publisher":425,"properties":475},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":426,"slug":10,"properties":427,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":431,"manageAffiliations":444,"indexDatabases":455,"url":22,"thumbnailPath":22,"statistic":470,"gsStatistic":22,"type":144,"analyzePriority":22},[],{"issn":428,"title":429,"eissn":430},{"VOID":15},{"EN":17},{"VOID":13},[432,436,440],{"id":26,"createTime":22,"updateTime":22,"relativeEntities":433,"label":434,"description":435,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":29},{},{"id":32,"createTime":22,"updateTime":22,"relativeEntities":437,"label":438,"description":439,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":35},{},{"id":38,"createTime":22,"updateTime":22,"relativeEntities":441,"label":442,"description":443,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":41},{},[445,450],{"id":45,"createTime":22,"updateTime":22,"relativeEntities":446,"slug":22,"properties":447,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":449,"statistic":22},[],{"title":448},{"EN":49},[51],{"id":53,"createTime":22,"updateTime":22,"relativeEntities":451,"slug":22,"properties":452,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":454,"statistic":22},[],{"title":453},{"EN":57},[],[456,463],{"id":61,"indexDatabase":457,"url":72,"indexYears":73,"academicFieldIds":462,"indexDatabaseRanking":78},{"id":63,"createTime":22,"updateTime":22,"relativeEntities":458,"label":459,"description":460,"key":69,"publicationTags":461,"standard":22},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75,76,77],{"id":80,"indexDatabase":464,"url":93,"indexYears":22,"academicFieldIds":469,"indexDatabaseRanking":22},{"id":82,"createTime":22,"updateTime":22,"relativeEntities":465,"label":466,"description":467,"key":89,"publicationTags":468,"standard":22},[],{"EN":85,"VI":85},{"EN":87,"VI":88},[91,92],[95,96],{"impactFactor":23,"impactFactorByYear":471,"i10Index":23,"i10IndexLast5Year":23,"totalPublication":100,"totalPublicationByYear":472,"totalCitation":136,"totalCitationByYear":473,"totalCitationPerPublication":23,"totalCitationPerPublicationByYear":474,"hindexLast5Year":138,"hindex":138},{"1989":99,"2014":23,"2021":23},{"1982":102,"1983":103,"1984":104,"1985":105,"1986":106,"1987":107,"1988":108,"1989":107,"1990":109,"1991":110,"1992":111,"1993":112,"1994":113,"1995":114,"1996":111,"1997":115,"1998":111,"1999":115,"2000":116,"2001":117,"2002":118,"2003":119,"2004":120,"2005":121,"2006":122,"2007":123,"2008":124,"2009":118,"2010":125,"2011":126,"2012":127,"2013":128,"2014":129,"2015":130,"2016":131,"2017":130,"2018":132,"2019":127,"2020":133,"2021":112,"2022":134,"2023":135,"2024":102},{"1987":138,"2012":139,"2019":140},{"1987":142,"2012":143,"2019":142},{"pages":476,"volume":478},{"VOID":477},"849-857",{"VOID":479},"31","2011-10-21",2011,[91,78],{"id":484,"createTime":485,"updateTime":486,"relativeEntities":487,"slug":488,"properties":489,"entityType":165,"verifyStatus":166,"verifyTime":499,"verifyNote":168,"languages":22,"translateLanguages":500,"viewCount":23,"primaryUrl":501,"fullTextUrl":22,"authors":502,"publicationType":218,"publisherRelationship":764,"citationCount":22,"citationInfo":22,"publishDate":818,"publishYear":819,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":820,"openAccess":22,"references":22,"isForceReanalyzing":278},"75f4d7c3-bd76-426b-99c1-bdcc76ea58fb","2023-12-14T13:50:37.806+00:00","2026-09-09T12:13:43.734+00:00",[],"Deciphering-mechanisms-affecting-cefepime-taniborbactam-in-vitro-activity-in-carbapenemase-producing-Enterobacterales-and-carbapenem-resistant-Pseudomonas-spp-isolates-recovered-during-a-surveillance-study-in-Spain",{"abstract":490,"title":492,"references":495,"doi":497},{"EN":491},"To characterize the resistance mechanisms affecting the cefepime-taniborbactam combination in a collection of carbapenemase-producing Enterobacterales (CPE) and carbapenem-resistant Pseudomonas spp. (predominantly P. aeruginosa; CRPA) clinical isolates. CPE (n = 247) and CRPA (n = 170) isolates were prospectively collected from patients admitted to 8 Spanish hospitals. Susceptibility to cefepime-taniborbactam and comparators was determined by broth microdilution. Cefepime-taniborbactam was the most active agent, inhibiting 97.6% of CPE and 67.1% of CRPA (MICs ≤ 8\u002F4 mg\u002FL). All isolates with cefepime-taniborbactam MIC > 8\u002F4 mg\u002FL (5 CPE and 52 CRPA) and a subset with MIC ≤ 8\u002F4 mg\u002FL (23 CPE and 24 CRPA) were characterized by whole genome sequencing. A reduced cefepime-taniborbactam activity was found in two KPC-ST307-Klebsiella pneumoniae isolates with altered porins [KPC-62-K. pneumoniae (OmpA, OmpR\u002FEnvZ), KPC-150-K. pneumoniae (OmpK35, OmpK36)] and one each ST133-VIM-1-Enterobacter hormaechei with altered OmpD, OmpR, and OmpC; IMP-8-ST24-Enterobacter asburiae; and NDM-5-Escherichia coli with an YRIN-inserted PBP3 and a mutated PBP2. Among the P. aeruginosa (68\u002F76), elevated cefepime-taniborbactam MICs were mostly associated with GES-5-ST235, OXA-2+VIM-2-ST235, and OXA-2+VIM-20-ST175 isolates also carrying mutations in PBP3, efflux pump (mexR, mexZ) and AmpC (mpl) regulators, and non-carbapenemase-ST175 isolates with AmpD-T139M and PBP3-R504C mutations. Overall, accumulation of these mutations was frequently detected among non-carbapenemase producers. The reduced cefepime-taniborbactam activity among the minority of isolates with elevated cefepime-taniborbactam MICs is not only due to IMP carbapenemases but also to the accumulation of multiple resistance mechanisms, including PBP and porin mutations in CPE and chromosomal mutations leading to efflux pumps up-regulation, AmpC overexpression, and PBP modifications in P. aeruginosa.",{"EN":493,"VI":494},"Deciphering mechanisms affecting cefepime-taniborbactam in vitro activity in carbapenemase-producing Enterobacterales and carbapenem-resistant Pseudomonas spp. isolates recovered during a surveillance study in Spain","Giải mã các cơ chế ảnh hưởng đến hoạt tính in vitro của cefepime-taniborbactam ở các chủng Enterobacterales sinh carbapenemase và Pseudomonas spp. kháng carbapenem thu thập trong nghiên cứu giám sát tại Tây Ban Nha",{"VOID":496},"Nordmann P, Naas T, Poirel L (2011) Global spread of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis 17:1791–1798 http:\u002F\u002Fwww.pubmedcentral.nih.gov\u002Farticlerender.fcgi?artid=3310682&tool=pmcentrez&rendertype=abstract10.3201\u002Feid1710.110655\nHorcajada JP, Montero M, Oliver A, Sorlí L, Luque S, Gómez-Zorrilla S et al (2019) Epidemiology and treatment of multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa infections. Clin Microbiol Rev 32:1–52. https:\u002F\u002Fdoi.org\u002F10.1128\u002FCMR.00031-19\nBotelho J, Grosso F, Peixe L (2019) Antibiotic resistance in Pseudomonas aeruginosa – mechanisms, epidemiology and evolution. Drug Resist Updat 44:26–47. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.drup.2019.07.002\nYahav D, Giske CG, Gramatniece A, Abodakpi H, Tam VH, Leibovici L (2021) New β-lactam–β-lactamase inhibitor combinations. Clin Microbiol Rev 1(34):1–61. https:\u002F\u002Fdoi.org\u002F10.1128\u002FCMR.00115-20\nVázquez-Ucha JC, Arca-Suárez J, Bou G, Beceiro A (2020) New carbapenemase inhibitors: clearing the way for the β-lactams. Int J Mol Sci 1(21):9308. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fijms21239308\nLiu B, Trout REL, Chu GH, Mcgarry D, Jackson RW, Hamrick JC et al (2020) Discovery of taniborbactam (VNRX-5133): a broad-spectrum serine- and metallo-β-lactamase inhibitor for carbapenem-resistant bacterial infections. J Med Chem 26(63):2789–2801. https:\u002F\u002Fdoi.org\u002F10.1021\u002Facs.jmedchem.9b01518\nHamrick JC, Docquier J-D, Uehara T, Myers CL, Six DA, Chatwin CL et al (2020) VNRX-5133 (Taniborbactam), a broad-spectrum inhibitor of serine-and metallo-lactamases, restores activity of cefepime in Enterobacterales and Pseudomonas aeruginosa. Antimicrob Agents Chemother 64:e01963–e01919\nKrajnc A, Brem J, Hinchliffe P, Calvopiña K, Panduwawala TD, Lang PA et al (2019) Bicyclic boronate VNRX-5133 inhibits metallo- and serine-β-lactamases. J Med Chem 26(62):8544–8556. https:\u002F\u002Fdoi.org\u002F10.1021\u002Facs.jmedchem.9b00911\nHernández-García M, García-Castillo M, Ruiz-Garbajosa P, Bou G, Siller-Ruiz M, Pitart C, Gracia-Ahufinger I et al (2022) In vitro activity of cefepime-taniborbactam against carbapenemase-producing Enterobacterales and Pseudomonas aeruginosa isolates recovered in Spain. Antimicrob Agents Chemother 66(3):e0216121. https:\u002F\u002Fdoi.org\u002F10.1128\u002Faac.02161-21\nHernández-García M, García-Castillo M, García-Fernández S, Melo-Cristino J, Pinto MF, Goncalves E et al (2020) Distinct epidemiology and resistance mechanisms affecting ceftolozane \u002F tazobactam in Pseudomonas aeruginosa isolates recovered from ICU patients in Spain and Portugal depicted by WGS. J Antimicrob Chemother 1–10. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjac\u002Fdkaa430\nHernández-García M, García-fernández S, García-castillo M, Melo-Cristino J, Pinto MF, Goncalves E et al (2020) Confronting ceftolozane-tazobactam susceptibility in multidrug-resistant Enterobacterales isolates and whole-genome sequencing results (STEP study). Int J Antimicrob Agents. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijantimicag.2020.106259\nOndov BD, Treangen TJ, Melsted P, Mallonee AB, Bergman NH, Koren S et al (2016) Mash: fast genome and metagenome distance estimation using MinHash. Genome Biol 17:1–14. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs13059-016-0997-x\nBeghain J, Bridier-Nahmias A, Le NH, Denamur E, Clermont O (2018) ClermonTyping: an easy-to-use and accurate in silico method for Escherichia genus strain phylotyping. Microb Genom 4:1–8. https:\u002F\u002Fdoi.org\u002F10.1099\u002Fmgen.0.000192\nLam MMC, Wick RR, Watts SC, Cerdeira LT, Wyres KL, Holt KE (2021) A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex. Nat Commun 12:4188. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41467-021-24448-3\nZankari E, Allesøe R, Joensen KG, Cavaco LM, Lund O, Aarestrup FM (2017) PointFinder: a novel web tool for WGS-based detection of antimicrobial resistance associated with chromosomal point mutations in bacterial pathogens. J Antimicrob Chemother 72:2764–2768. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjac\u002Fdkx217\nTacconelli E, Carrara E, Savoldi A, Harbarth S, Mendelson M, Monnet DL et al (2018) Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect Dis 18:318–327. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS1473-3099(17)30753-3\nKarlowsky JA, Hackel MA, Wise MG, Six DA, Uehara T, Daigle DM et al (2023) In vitro activity of cefepime-taniborbactam and comparators against clinical isolates of gram-negative bacilli from 2018 to 2020: results from the Global Evaluation of Antimicrobial Resistance via Surveillance (GEARS) Program. Antimicrob Agents Chemother 1:67. https:\u002F\u002Fdoi.org\u002F10.1128\u002Faac.01281-22\nShields RK, Chen L, Cheng S, Chavda KD, Press EG (2016) Emergence of ceftazidime-avibactam resistance fue to plasmid-borne blaKPC-3 mutations during treatment of carbapenem-resistant Klebsiella pneumoniae infections. Antimicrob Agents Chemother 61:1–11. https:\u002F\u002Fdoi.org\u002F10.1128\u002FAAC.02097-16\nBianco G, Boattini M, Comini S, Iannaccone M, Bondi A, Cavallo R et al (2022) In vitro activity of cefiderocol against ceftazidime-avibactam susceptible and resistant KPC-producing Enterobacterales: cross-resistance and synergistic effects. Eur J Clin Microbiol Infect Dis 1(41):63–70. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs10096-021-04341-z\nDaigle D, Hamrick J, Chatwin C, Kurepina N, Kreiswirth BN, Shields RK, Oliver A, Clancy CJ, Nguyen MH, Pevear D, Xerri L (2018) Cefepime\u002FVNRX-5133 broad-spectrum activity is maintained against emerging KPC- and PDC-variants in multidrug-resistant K. pneumoniae and P. aeruginosa. Open Forum Infect Dis Ther 5(Suppl):1\nCastillo-Polo JA, Hernández-García M, Morosini MI, Pérez-Viso B, Soriano C, De Pablo R et al (2023) Outbreak by KPC-62-producing ST307 Klebsiella pneumoniae isolates resistant to ceftazidime\u002Favibactam and cefiderocol in a university hospital in Madrid, Spain. J Antimicrob Chemother 25. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjac\u002Fdkad086\nSatapoomin N, Dulyayangkul P, Avison MB (2022) Klebsiella pneumoniae mutants resistant to ceftazidime- avibactam plus aztreonam, imipenem-relebactam, meropenem-vaborbactam, and cefepime-taniborbactam. Antimicrob Agents Chemother 1:66. https:\u002F\u002Fdoi.org\u002F10.1128\u002Faac.02179-21\nAlm RA, Johnstone MR, Lahiri SD (2014) Characterization of Escherichia coli NDM isolates with decreased susceptibility to aztreonam\u002Favibactam: Role of a novel insertion in PBP3. J Antimicrob Chemother 20(70):1420–1428. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjac\u002Fdku568\nSato T, Ito A, Ishioka Y, Matsumoto S, Rokushima M, Kazmierczak KM et al (2020) Escherichia coli strains possessing a four amino acid YRIN insertion in PBP3 identified as part of the SIDERO-WT-2014 surveillance study. JAC Antimicrob Resist 1:2. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjacamr\u002Fdlaa081\nWang X, Zhao C, Wang Q, Wang Z, Liang X, Zhang F et al (2020) In vitro activity of the novel β-lactamase inhibitor taniborbactam (VNRX-5133), in combination with cefepime or meropenem, against MDR Gram-negative bacterial isolates from China. J Antimicrob Chemother 1(75):1850–1858. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjac\u002Fdkaa053\nRanjitkar S, Reck F, Ke X, Zhu Q, McEnroe G, Lopez SL et al (2019) Identification of mutations in the mrdA gene encoding PBP2 that reduce carbapenem and diazabicyclooctane susceptibility of Escherichia coli clinical isolates with mutations in ftsI (PBP3) and which carry blaNDM-1. mSphere 28:4. https:\u002F\u002Fdoi.org\u002F10.1128\u002Fmsphere.00074-19\nVázquez-Ucha JC, Lasarte-Monterrubio C, Guijarro-Sánchez P, Oviaño M, Álvarez-Fraga L, Alonso-García I et al (2022) Assessment of activity and resistance mechanisms to cefepime in combination with the novel β-lactamase inhibitors zidebactam, taniborbactam, and enmetazobactam against a multicenter collection of carbapenemase-producing Enterobacterales. Antimicrob Agents Chemother 1:66. https:\u002F\u002Fdoi.org\u002F10.1128\u002FAAC.01676-21\nLe Terrier C, Nordmann P, Sadek M, Poirel L (2023) In vitro activity of cefepime\u002Fzidebactam and cefepime\u002Ftaniborbactam against aztreonam\u002Favibactam-resistant NDM-like-producing Escherichia coli clinical isolates. J Antimicrob Chemother 1(78):1191–1194. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjac\u002Fdkad061\nGolden AR, Baxter MR, Karlowsky JA, Mataseje L, Mulvey MR, Walkty A et al (2022) Activity of cefepime\u002Ftaniborbactam and comparators against whole genome sequenced ertapenem-non-susceptible Enterobacterales clinical isolates: CANWARD 2007-19. JAC Antimicrob Resist 1:4. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjacamr\u002Fdlab197\nLe Terrier C, Nordmann P, Freret C, Seigneur M, Poirel L (2023) Impact of acquired broad spectrum b-lactamases on susceptibility to novel combinations made of β-lactams (aztreonam, cefepime, meropenem, and imipenem) and novel β-lactamase inhibitors in Escherichia coli and Pseudomonas aeruginosa. Antimicrob Agents Chemother 1:67. https:\u002F\u002Fdoi.org\u002F10.1128\u002Faac.00339-23\nLasarte-Monterrubio C, Fraile-Ribot PA, Vázquez-Ucha JC, Cabot G, Guijarro-Sánchez P, Alonso-García I et al (2022) Activity of cefiderocol, imipenem\u002Frelebactam, cefepime\u002Ftaniborbactam and cefepime\u002Fzidebactam against ceftolozane\u002Ftazobactam- and ceftazidime\u002Favibactam-resistant Pseudomonas aeruginosa. J Antimicrob Chemother 1(77):2809–2815. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjac\u002Fdkac241\nPérez-Vázquez M, Sola-Campoy PJ, Zurita ÁM, Ávila A, Gómez-Bertomeu F, Solís S et al (2020) Carbapenemase-producing Pseudomonas aeruginosa in Spain: interregional dissemination of the high-risk clones ST175 and ST244 carrying blaVIM-2, blaVIM-1, blaIMP-8, blaVIM-20 and blaKPC-2. Int J Antimicrob Agents 1(56). https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijantimicag.2020.106026\nHernández-García M, García-Castillo M, Melo-Cristino J, Pinto MF, Gonçalves E, Alves V et al (2022) In vitro activity of imipenem\u002Frelebactam against Pseudomonas aeruginosa isolates recovered from ICU patients in Spain and Portugal (SUPERIOR and STEP studies). J Antimicrob Chemother 1(77):3163–3172. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjac\u002Fdkac298\nLópez-Causapé C, Cabot G, del Barrio-Tofiño E, Oliver A (2018) The versatile mutational resistome of Pseudomonas aeruginosa. Front Microbiol 6:9. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffmicb.2018.00685",{"VOID":498},"10.1007\u002Fs10096-023-04697-4","2025-01-11T22:26:11.926+00:00",[170],"https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs10096-023-04697-4",[503,527,547,560,582,604,619,641,663,686,701,722,743],{"id":504,"sortIndex":23,"researcher":22,"roles":505,"affiliations":506,"properties":524,"displayName":526,"givenName":22,"familyName":22},"b99e7a6c-6acb-4c4e-8b1f-e5ac6305498b",[176],[507,515],{"id":508,"sortIndex":23,"affiliation":509,"properties":22},"69cfd455-edbf-42ec-9143-80bf9853e9b9",{"id":508,"createTime":22,"updateTime":22,"relativeEntities":510,"slug":22,"properties":511,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":514,"statistic":22},[],{"title":512},{"VI":513},"Servicio de Microbiología, Hospital Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain",[],{"id":516,"sortIndex":191,"affiliation":517,"properties":523},"19d7d1a9-3d11-4cbc-9dee-987d9bf1b1c2",{"id":516,"createTime":22,"updateTime":22,"relativeEntities":518,"slug":22,"properties":519,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":522,"statistic":22},[],{"title":520},{"VI":521},"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain",[],{},{"title":525},{"VI":526},"Marta Hernández-García",{"id":528,"sortIndex":191,"researcher":22,"roles":529,"affiliations":530,"properties":544,"displayName":546,"givenName":22,"familyName":22},"b69daa2d-f359-46fb-897a-ddec434ed2e1",[176],[531,537],{"id":508,"sortIndex":23,"affiliation":532,"properties":22},{"id":508,"createTime":22,"updateTime":22,"relativeEntities":533,"slug":22,"properties":534,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":536,"statistic":22},[],{"title":535},{"VI":513},[],{"id":516,"sortIndex":191,"affiliation":538,"properties":543},{"id":516,"createTime":22,"updateTime":22,"relativeEntities":539,"slug":22,"properties":540,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":542,"statistic":22},[],{"title":541},{"VI":521},[],{},{"title":545},{"VI":546},"María García-Castillo",{"id":548,"sortIndex":138,"researcher":22,"roles":549,"affiliations":550,"properties":557,"displayName":559,"givenName":22,"familyName":22},"ec373071-0547-4b99-b371-66b36b48f284",[176],[551],{"id":508,"sortIndex":23,"affiliation":552,"properties":22},{"id":508,"createTime":22,"updateTime":22,"relativeEntities":553,"slug":22,"properties":554,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":556,"statistic":22},[],{"title":555},{"VI":513},[],{"title":558},{"VI":559},"Marta Nieto-Torres",{"id":561,"sortIndex":140,"researcher":22,"roles":562,"affiliations":563,"properties":579,"displayName":581,"givenName":22,"familyName":22},"2d73c36a-1ccc-41ae-8946-afb18ce28ec7",[176],[564,570],{"id":516,"sortIndex":23,"affiliation":565,"properties":22},{"id":516,"createTime":22,"updateTime":22,"relativeEntities":566,"slug":22,"properties":567,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":569,"statistic":22},[],{"title":568},{"VI":521},[],{"id":571,"sortIndex":191,"affiliation":572,"properties":578},"ea050f38-d4d7-461a-8acb-da1bc8a237f9",{"id":571,"createTime":22,"updateTime":22,"relativeEntities":573,"slug":22,"properties":574,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":577,"statistic":22},[],{"title":575},{"VI":576},"Servicio de Microbiología, Hospital Universitario A Coruña and Instituto de Investigación Biomédica A Coruña (INIBIC), A Coruña, Spain",[],{},{"title":580},{"VI":581},"Germán Bou",{"id":583,"sortIndex":366,"researcher":22,"roles":584,"affiliations":585,"properties":601,"displayName":603,"givenName":22,"familyName":22},"f03c27b6-8205-48f3-82ae-8d719572f4e0",[176],[586,592],{"id":516,"sortIndex":23,"affiliation":587,"properties":22},{"id":516,"createTime":22,"updateTime":22,"relativeEntities":588,"slug":22,"properties":589,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":591,"statistic":22},[],{"title":590},{"VI":521},[],{"id":593,"sortIndex":191,"affiliation":594,"properties":600},"f22ebef6-692f-4ff6-8025-38570b7ca73a",{"id":593,"createTime":22,"updateTime":22,"relativeEntities":595,"slug":22,"properties":596,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":599,"statistic":22},[],{"title":597},{"VI":598},"Servicio de Microbiología, Hospital Universitario Marqués de Valdecilla and Instituto de Investigación Sanitaria Valdecilla (IDIVAL), Santander, Spain",[],{},{"title":602},{"VI":603},"Alain Ocampo-Sosa",{"id":605,"sortIndex":382,"researcher":22,"roles":606,"affiliations":607,"properties":616,"displayName":618,"givenName":22,"familyName":22},"453a08b5-c164-45b7-b86e-1a0826c6edc9",[176],[608],{"id":609,"sortIndex":23,"affiliation":610,"properties":22},"20219506-523c-4eb7-84b9-d59401b89fe5",{"id":609,"createTime":22,"updateTime":22,"relativeEntities":611,"slug":22,"properties":612,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":615,"statistic":22},[],{"title":613},{"VI":614},"Laboratorio de Microbiología, Hospital Clínic i Provincial, Barcelona, Spain",[],{"title":617},{"VI":618},"Cristina Pitart",{"id":620,"sortIndex":396,"researcher":22,"roles":621,"affiliations":622,"properties":638,"displayName":640,"givenName":22,"familyName":22},"7256ce28-7b79-48b7-894c-f35e0c2069f8",[176],[623,629],{"id":516,"sortIndex":23,"affiliation":624,"properties":22},{"id":516,"createTime":22,"updateTime":22,"relativeEntities":625,"slug":22,"properties":626,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":628,"statistic":22},[],{"title":627},{"VI":521},[],{"id":630,"sortIndex":191,"affiliation":631,"properties":637},"9dffc057-3e36-466b-9c24-1152ebf6ae19",{"id":630,"createTime":22,"updateTime":22,"relativeEntities":632,"slug":22,"properties":633,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":636,"statistic":22},[],{"title":634},{"VI":635},"UGC de Microbiología, Hospital Universitario Reina Sofía-Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain",[],{},{"title":639},{"VI":640},"Irene Gracia-Ahufinger",{"id":642,"sortIndex":412,"researcher":22,"roles":643,"affiliations":644,"properties":660,"displayName":662,"givenName":22,"familyName":22},"eb07a4f9-5f3a-4f13-82e4-a9ee278b7dad",[176],[645,651],{"id":516,"sortIndex":23,"affiliation":646,"properties":22},{"id":516,"createTime":22,"updateTime":22,"relativeEntities":647,"slug":22,"properties":648,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":650,"statistic":22},[],{"title":649},{"VI":521},[],{"id":652,"sortIndex":191,"affiliation":653,"properties":659},"8003de23-20fd-4e9e-8071-4a33b9a171bd",{"id":652,"createTime":22,"updateTime":22,"relativeEntities":654,"slug":22,"properties":655,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":658,"statistic":22},[],{"title":656},{"VI":657},"Servicio de Microbiología, Hospital Universitario Son Espases and Instituto de investigación Sanitaria Illes Balears (idISBa), Palma de Mallorca, Spain",[],{},{"title":661},{"VI":662},"Xavier Mulet",{"id":664,"sortIndex":665,"researcher":22,"roles":666,"affiliations":667,"properties":683,"displayName":685,"givenName":22,"familyName":22},"d5c76f93-5c7e-4c88-a098-a8b8f768c841",8,[176],[668,674],{"id":516,"sortIndex":23,"affiliation":669,"properties":22},{"id":516,"createTime":22,"updateTime":22,"relativeEntities":670,"slug":22,"properties":671,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":673,"statistic":22},[],{"title":672},{"VI":521},[],{"id":675,"sortIndex":191,"affiliation":676,"properties":682},"2f581762-f624-4527-9798-029283713163",{"id":675,"createTime":22,"updateTime":22,"relativeEntities":677,"slug":22,"properties":678,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":681,"statistic":22},[],{"title":679},{"VI":680},"Unidad de Enfermedades Infecciosas y Microbiología Clínica, Hospital Universitario Virgen Macarena, Departamento de Microbiología, Universidad de Sevilla and Instituto de Biomedicina de Sevilla (IBiS) (Hospital Universitario Virgen Macarena\u002FCSIC\u002FUniversidad de Sevilla), Sevilla, Spain",[],{},{"title":684},{"VI":685},"Álvaro Pascual",{"id":687,"sortIndex":139,"researcher":22,"roles":688,"affiliations":689,"properties":698,"displayName":700,"givenName":22,"familyName":22},"2b6ce093-474d-44cd-ab14-0e4391d96738",[176],[690],{"id":691,"sortIndex":23,"affiliation":692,"properties":22},"a690af9e-09ef-4e21-93d1-cb860911f692",{"id":691,"createTime":22,"updateTime":22,"relativeEntities":693,"slug":22,"properties":694,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":697,"statistic":22},[],{"title":695},{"VI":696},"Servicio de Microbiología, Consorcio Hospital General Universitario de Valencia, Valencia, Spain",[],{"title":699},{"VI":700},"Nuria Tormo",{"id":702,"sortIndex":703,"researcher":22,"roles":704,"affiliations":705,"properties":719,"displayName":721,"givenName":22,"familyName":22},"41035f8b-eebc-429c-a8a7-2bd46cb89f3f",10,[176],[706,712],{"id":516,"sortIndex":23,"affiliation":707,"properties":22},{"id":516,"createTime":22,"updateTime":22,"relativeEntities":708,"slug":22,"properties":709,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":711,"statistic":22},[],{"title":710},{"VI":521},[],{"id":652,"sortIndex":191,"affiliation":713,"properties":718},{"id":652,"createTime":22,"updateTime":22,"relativeEntities":714,"slug":22,"properties":715,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":717,"statistic":22},[],{"title":716},{"VI":657},[],{},{"title":720},{"VI":721},"Antonio Oliver",{"id":723,"sortIndex":724,"researcher":22,"roles":725,"affiliations":726,"properties":740,"displayName":742,"givenName":22,"familyName":22},"d53cce01-b482-46b8-9812-685b984ccbe3",11,[176],[727,733],{"id":508,"sortIndex":23,"affiliation":728,"properties":22},{"id":508,"createTime":22,"updateTime":22,"relativeEntities":729,"slug":22,"properties":730,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":732,"statistic":22},[],{"title":731},{"VI":513},[],{"id":516,"sortIndex":191,"affiliation":734,"properties":739},{"id":516,"createTime":22,"updateTime":22,"relativeEntities":735,"slug":22,"properties":736,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":738,"statistic":22},[],{"title":737},{"VI":521},[],{},{"title":741},{"VI":742},"Patricia Ruiz-Garbajosa",{"id":744,"sortIndex":745,"researcher":22,"roles":746,"affiliations":747,"properties":761,"displayName":763,"givenName":22,"familyName":22},"8df92843-1be2-493b-9324-38d55fb57a2c",12,[176],[748,754],{"id":508,"sortIndex":23,"affiliation":749,"properties":22},{"id":508,"createTime":22,"updateTime":22,"relativeEntities":750,"slug":22,"properties":751,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":753,"statistic":22},[],{"title":752},{"VI":513},[],{"id":516,"sortIndex":191,"affiliation":755,"properties":760},{"id":516,"createTime":22,"updateTime":22,"relativeEntities":756,"slug":22,"properties":757,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":759,"statistic":22},[],{"title":758},{"VI":521},[],{},{"title":762},{"VI":763},"Rafael Cantón",{"url":501,"publisher":765,"properties":815},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":766,"slug":10,"properties":767,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":771,"manageAffiliations":784,"indexDatabases":795,"url":22,"thumbnailPath":22,"statistic":810,"gsStatistic":22,"type":144,"analyzePriority":22},[],{"issn":768,"title":769,"eissn":770},{"VOID":15},{"EN":17},{"VOID":13},[772,776,780],{"id":26,"createTime":22,"updateTime":22,"relativeEntities":773,"label":774,"description":775,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":29},{},{"id":32,"createTime":22,"updateTime":22,"relativeEntities":777,"label":778,"description":779,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":35},{},{"id":38,"createTime":22,"updateTime":22,"relativeEntities":781,"label":782,"description":783,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":41},{},[785,790],{"id":45,"createTime":22,"updateTime":22,"relativeEntities":786,"slug":22,"properties":787,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":789,"statistic":22},[],{"title":788},{"EN":49},[51],{"id":53,"createTime":22,"updateTime":22,"relativeEntities":791,"slug":22,"properties":792,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":794,"statistic":22},[],{"title":793},{"EN":57},[],[796,803],{"id":61,"indexDatabase":797,"url":72,"indexYears":73,"academicFieldIds":802,"indexDatabaseRanking":78},{"id":63,"createTime":22,"updateTime":22,"relativeEntities":798,"label":799,"description":800,"key":69,"publicationTags":801,"standard":22},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75,76,77],{"id":80,"indexDatabase":804,"url":93,"indexYears":22,"academicFieldIds":809,"indexDatabaseRanking":22},{"id":82,"createTime":22,"updateTime":22,"relativeEntities":805,"label":806,"description":807,"key":89,"publicationTags":808,"standard":22},[],{"EN":85,"VI":85},{"EN":87,"VI":88},[91,92],[95,96],{"impactFactor":23,"impactFactorByYear":811,"i10Index":23,"i10IndexLast5Year":23,"totalPublication":100,"totalPublicationByYear":812,"totalCitation":136,"totalCitationByYear":813,"totalCitationPerPublication":23,"totalCitationPerPublicationByYear":814,"hindexLast5Year":138,"hindex":138},{"1989":99,"2014":23,"2021":23},{"1982":102,"1983":103,"1984":104,"1985":105,"1986":106,"1987":107,"1988":108,"1989":107,"1990":109,"1991":110,"1992":111,"1993":112,"1994":113,"1995":114,"1996":111,"1997":115,"1998":111,"1999":115,"2000":116,"2001":117,"2002":118,"2003":119,"2004":120,"2005":121,"2006":122,"2007":123,"2008":124,"2009":118,"2010":125,"2011":126,"2012":127,"2013":128,"2014":129,"2015":130,"2016":131,"2017":130,"2018":132,"2019":127,"2020":133,"2021":112,"2022":134,"2023":135,"2024":102},{"1987":138,"2012":139,"2019":140},{"1987":142,"2012":143,"2019":142},{"pages":816},{"VOID":817},"1-18","2023-12-02",2023,[91,78],{"id":822,"createTime":823,"updateTime":824,"relativeEntities":825,"slug":826,"properties":827,"entityType":165,"verifyStatus":166,"verifyTime":837,"verifyNote":168,"languages":22,"translateLanguages":838,"viewCount":23,"primaryUrl":839,"fullTextUrl":22,"authors":840,"publicationType":218,"publisherRelationship":938,"citationCount":22,"citationInfo":22,"publishDate":994,"publishYear":819,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":995,"openAccess":22,"references":22,"isForceReanalyzing":278},"1131bf82-1a9d-44a6-96e3-5930bca820ef","2023-12-06T09:41:46.570+00:00","2026-09-09T09:13:08.024+00:00",[],"Two-site-study-on-performances-of-a-commercially-available-MALDI-TOF-MS-based-assay-for-the-detection-of-colistin-resistance-in-Escherichia-coli",{"abstract":828,"title":830,"references":833,"doi":835},{"EN":829},"Colistin is a last resort drug for the treatment of multiple drug-resistant (MDR) Gram-negative bacterial infections. Rapid methods to detect resistance are highly desirable. Here, we evaluated the performance of a commercially available MALDI-TOF MS-based assay for colistin resistance testing in Escherichia coli at two different sites. Ninety clinical E. coli isolates were provided by France and tested in Germany and UK using a MALDI-TOF MS-based colistin resistance assay. Lipid A molecules of the bacterial cell membrane were extracted using the MBT Lipid Xtract Kit™ (RUO; Bruker Daltonics, Germany). Spectra acquisition and evaluation were performed by the MBT HT LipidART Module of MBT Compass HT (RUO; Bruker Daltonics) on a MALDI Biotyper® sirius system (Bruker Daltonics) in negative ion mode. Phenotypic colistin resistance was determined by broth microdilution (MICRONAUT MIC-Strip Colistin, Bruker Daltonics) and used as a reference. Comparing the results of the MALDI-TOF MS-based colistin resistance assay with the data of the phenotypic reference method for the UK, sensitivity and specificity for the detection of colistin resistance were 97.1% (33\u002F34) and 96.4% (53\u002F55), respectively. Germany showed 97.1% (33\u002F34) sensitivity and 100% (55\u002F55) specificity for the detection of colistin resistance by MALDI-TOF MS. Applying the MBT Lipid Xtract™ Kit in combination with MALDI-TOF MS and dedicated software showed excellent performances for E. coli. Analytical and clinical validation studies must be performed to demonstrate the performance of the method as a diagnostic tool.",{"EN":831,"VI":832},"Two-site study on performances of a commercially available MALDI-TOF MS-based assay for the detection of colistin resistance in Escherichia coli","Nghiên cứu tại hai địa điểm về hiệu năng của xét nghiệm thương mại dựa trên MALDI-TOF MS nhằm phát hiện tính kháng colistin ở Escherichia coli",{"VOID":834},"Rochford C, Sridhar D, Woods N, Saleh Z, Hartenstein L, Ahlawat H, Whiting E, Dybul M, Cars O, Goosby E, Cassels A, Velasquez G, Hoffman S, Baris E, Wadsworth J, Gyansa-Lutterodt M, Davies S (2018) Global governance of antimicrobial resistance. Lancet 391:1976–1978\nKontopidou F, Giamarellou H, Katerelos P, Maragos A, Kioumis I, Trikka-Graphakos E, Valakis C, Maltezou HC, Group for the study of KPCpKpiiicu (2014) Infections caused by carbapenem-resistant Klebsiella pneumoniae among patients in intensive care units in Greece: a multi-centre study on clinical outcome and therapeutic options. Clin Microbiol Infect 20:O117-23\nFalagas ME, Kasiakou SK (2005) Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections. Clin Infect Dis 40:1333–1341\nJeannot K, Bolard A, Plesiat P (2017) Resistance to polymyxins in Gram-negative organisms. Int J Antimicrob Agents 49:526–535\nOlaitan AO, Morand S, Rolain JM (2014) Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria. Front Microbiol 5:643\nPoirel L, Jayol A, Nordmann P (2017) Polymyxins: antibacterial activity, susceptibility testing, and resistance mechanisms encoded by plasmids or chromosomes. Clin Microbiol Rev 30:557–596\nLiu YY, Wang Y, Walsh TR, Yi LX, Zhang R, Spencer J, Doi Y, Tian G, Dong B, Huang X, Yu LF, Gu D, Ren H, Chen X, Lv L, He D, Zhou H, Liang Z, Liu JH, Shen J (2016) Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis 16:161–8\nZhang H, Hou M, Xu Y, Srinivas S, Huang M, Liu L, Feng Y (2019) Action and mechanism of the colistin resistance enzyme MCR-4. Commun Biol 2:36\nWang X, Wang Y, Zhou Y, Li J, Yin W, Wang S, Zhang S, Shen J, Shen Z, Wang Y (2018) Emergence of a novel mobile colistin resistance gene, mcr-8, in NDM-producing Klebsiella pneumoniae. Emerg Microbes Infect 7:122\nYang YQ, Li YX, Lei CW, Zhang AY, Wang HN (2018) Novel plasmid-mediated colistin resistance gene mcr-7.1 in Klebsiella pneumoniae. J Antimicrob Chemother 73:1791–1795\nCarroll LM, Gaballa A, Guldimann C, Sullivan G, Henderson LO, Wiedmann M (2019) Identification of novel mobilized colistin resistance gene mcr-9 in a multidrug-resistant, colistin-susceptible Salmonella enterica serotype Typhimurium isolate. MBio 10(3):e00853-19. https:\u002F\u002Fdoi.org\u002F10.1128\u002FmBio.00853-19\nDortet L, Potron A, Bonnin RA, Plesiat P, Naas T, Filloux A, Larrouy-Maumus G (2018) Rapid detection of colistin resistance in Acinetobacter baumannii using MALDI-TOF-based lipidomics on intact bacteria. Sci Rep 8:16910\nDortet L, Bonnin RA, Pennisi I, Gauthier L, Jousset AB, Dabos L, Furniss RCD, Mavridou DAI, Bogaerts P, Glupczynski Y, Potron A, Plesiat P, Beyrouthy R, Robin F, Bonnet R, Naas T, Filloux A, Larrouy-Maumus G (2018) Rapid detection and discrimination of chromosome- and MCR-plasmid-mediated resistance to polymyxins by MALDI-TOF MS in Escherichia coli: the MALDIxin test. J Antimicrob Chemother 73:3359–3367\nJeannot K, Hagart K, Dortet L, Kostrzewa M, Filloux A, Plesiat P, Larrouy-Maumus G (2021) Detection of colistin resistance in Pseudomonas aeruginosa using the MALDIxin test on the routine MALDI Biotyper sirius mass spectrometer. Front Microbiol 12:725383\nFurniss RCD, Kostrzewa M, Mavridou DAI, Larrouy-Maumus G (2020) The clue is in the lipid A: rapid detection of colistin resistance. PLoS Pathog 16:e1008331\nDortet L, Bonnin RA, Le Hello S, Fabre L, Bonnet R, Kostrzewa M, Filloux A, Larrouy-Maumus G (2020) Detection of colistin resistance in Salmonella enterica using MALDIxin test on the routine MALDI Biotyper sirius mass spectrometer. Front Microbiol 11:1141\nDortet L, Broda A, Bernabeu S, Glupczynski Y, Bogaerts P, Bonnin R, Naas T, Filloux A, Larrouy-Maumus G (2020) Optimization of the MALDIxin test for the rapid identification of colistin resistance in Klebsiella pneumoniae using MALDI-TOF MS. J Antimicrob Chemother 75:110–116\nFurniss RCD, Dortet L, Bolland W, Drews O, Sparbier K, Bonnin RA, Filloux A, Kostrzewa M, Mavridou DAI, Larrouy-Maumus G (2019) Detection of colistin resistance in Escherichia coli using the MALDI Biotyper sirius mass spectrometry system. J Clin Microbiol. https:\u002F\u002Fdoi.org\u002F10.1128\u002FJCM.01427-19\nJousset AB, Bernabeu S, Bonnin RA, Creton E, Cotellon G, Sauvadet A, Naas T, Dortet L (2019) Development and validation of a multiplex polymerase chain reaction assay for detection of the five families of plasmid-encoded colistin resistance. Int J Antimicrob Agents 53:302–309\nPoirel L, Dortet L, Bernabeu S, Nordmann P (2011) Genetic features of blaNDM-1-positive Enterobacteriaceae. Antimicrob Agents Chemother 55:5403–5407\nClinical laboratory testing and in vitro diagnostic test systems - susceptibility testing of infectious agents and evaluation of performance of antimicrobial susceptibility test devices - part 2: evaluation of performance of antimicrobial susceptibility test devices against reference broth microdilution. International Organization for Standardization ISO 20776–2 (2021)\nMatuschek E, Ahman J, Webster C, Kahlmeter G (2018) Antimicrobial susceptibility testing of colistin - evaluation of seven commercial MIC products against standard broth microdilution for Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter spp. Clin Microbiol Infect 24:865–870\nEUCAST (2022) Breakpoint tables for interpretation of MICs and zone diameters The European Committee on Antimicrobial Susceptibility Testing https:\u002F\u002Fwww.eucast.org\u002Fclinical_breakpoints\nTkadlec J, Kalova A, Brajerova M, Gelbicova T, Karpiskova R, Smelikova E, Nyc O, Drevinek P, Krutova M (2021) The intestinal carriage of plasmid-mediated colistin-resistant Enterobacteriaceae in tertiary care settings. Antibiotics (Basel) 10\nLedger EVK, Mesnage S, Edwards AM (2022) Human serum triggers antibiotic tolerance in Staphylococcus aureus. Nat Commun 13:2041\nSmelikova E, Tkadlec J, Krutova M (2022) How to: screening for mcr-mediated resistance to colistin. Clin Microbiol Infect 28:43–50",{"VOID":836},"10.1007\u002Fs10096-023-04587-9","2025-01-07T03:31:02.476+00:00",[170],"https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs10096-023-04587-9",[841,856,871,886,899,912,925],{"id":842,"sortIndex":23,"researcher":22,"roles":843,"affiliations":844,"properties":853,"displayName":855,"givenName":22,"familyName":22},"bf13eb35-fee1-4fc5-af9d-667ac1503838",[176],[845],{"id":846,"sortIndex":23,"affiliation":847,"properties":22},"2ab3e43c-7448-49c6-a759-9d27bb591cd9",{"id":846,"createTime":22,"updateTime":22,"relativeEntities":848,"slug":22,"properties":849,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":852,"statistic":22},[],{"title":850},{"VI":851},"Centre for Bacterial Resistance Biology, Department of Life Sciences, Imperial College London, London, UK",[],{"title":854},{"VI":855},"Gerald Larrouy-Maumus",{"id":857,"sortIndex":191,"researcher":22,"roles":858,"affiliations":859,"properties":868,"displayName":870,"givenName":22,"familyName":22},"abdee247-f0b4-41d6-8daf-e5e0a0948e3f",[176],[860],{"id":861,"sortIndex":23,"affiliation":862,"properties":22},"2e50ca65-0730-4001-a408-b65624ec199a",{"id":861,"createTime":22,"updateTime":22,"relativeEntities":863,"slug":22,"properties":864,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":867,"statistic":22},[],{"title":865},{"VI":866},"Department of Bacteriology-Hygiene, Bicêtre Hospital, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, France",[],{"title":869},{"VI":870},"Laurent Dortet",{"id":872,"sortIndex":138,"researcher":22,"roles":873,"affiliations":874,"properties":883,"displayName":885,"givenName":22,"familyName":22},"58c77506-4118-48ea-ba0d-ceb78256b97d",[176],[875],{"id":876,"sortIndex":23,"affiliation":877,"properties":22},"33d8e9dd-2190-41ee-b9d3-db3d874ae743",{"id":876,"createTime":22,"updateTime":22,"relativeEntities":878,"slug":22,"properties":879,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":882,"statistic":22},[],{"title":880},{"VI":881},"Bruker Daltonics GmbH & Co KG, Bremen, Germany",[],{"title":884},{"VI":885},"Ilka D. Nix",{"id":887,"sortIndex":140,"researcher":22,"roles":888,"affiliations":889,"properties":896,"displayName":898,"givenName":22,"familyName":22},"99d8ab32-b1c0-49d0-8e77-88a8e9070df9",[176],[890],{"id":876,"sortIndex":23,"affiliation":891,"properties":22},{"id":876,"createTime":22,"updateTime":22,"relativeEntities":892,"slug":22,"properties":893,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":895,"statistic":22},[],{"title":894},{"VI":881},[],{"title":897},{"VI":898},"Thomas Maier",{"id":900,"sortIndex":366,"researcher":22,"roles":901,"affiliations":902,"properties":909,"displayName":911,"givenName":22,"familyName":22},"5a31b3d6-abc7-45b8-beca-830503336c9e",[176],[903],{"id":876,"sortIndex":23,"affiliation":904,"properties":22},{"id":876,"createTime":22,"updateTime":22,"relativeEntities":905,"slug":22,"properties":906,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":908,"statistic":22},[],{"title":907},{"VI":881},[],{"title":910},{"VI":911},"Boris Oberheitmann",{"id":913,"sortIndex":382,"researcher":22,"roles":914,"affiliations":915,"properties":922,"displayName":924,"givenName":22,"familyName":22},"e7037913-e6a9-4621-ba62-29bcdbd19fbd",[176],[916],{"id":876,"sortIndex":23,"affiliation":917,"properties":22},{"id":876,"createTime":22,"updateTime":22,"relativeEntities":918,"slug":22,"properties":919,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":921,"statistic":22},[],{"title":920},{"VI":881},[],{"title":923},{"VI":924},"Katrin Sparbier",{"id":926,"sortIndex":396,"researcher":22,"roles":927,"affiliations":928,"properties":935,"displayName":937,"givenName":22,"familyName":22},"60a2a9b9-8160-4ae9-be85-9201ccc2b6c0",[176],[929],{"id":876,"sortIndex":23,"affiliation":930,"properties":22},{"id":876,"createTime":22,"updateTime":22,"relativeEntities":931,"slug":22,"properties":932,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":934,"statistic":22},[],{"title":933},{"VI":881},[],{"title":936},{"VI":937},"Markus Kostrzewa",{"url":839,"publisher":939,"properties":989},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":940,"slug":10,"properties":941,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":945,"manageAffiliations":958,"indexDatabases":969,"url":22,"thumbnailPath":22,"statistic":984,"gsStatistic":22,"type":144,"analyzePriority":22},[],{"issn":942,"title":943,"eissn":944},{"VOID":15},{"EN":17},{"VOID":13},[946,950,954],{"id":26,"createTime":22,"updateTime":22,"relativeEntities":947,"label":948,"description":949,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":29},{},{"id":32,"createTime":22,"updateTime":22,"relativeEntities":951,"label":952,"description":953,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":35},{},{"id":38,"createTime":22,"updateTime":22,"relativeEntities":955,"label":956,"description":957,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":41},{},[959,964],{"id":45,"createTime":22,"updateTime":22,"relativeEntities":960,"slug":22,"properties":961,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":963,"statistic":22},[],{"title":962},{"EN":49},[51],{"id":53,"createTime":22,"updateTime":22,"relativeEntities":965,"slug":22,"properties":966,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":968,"statistic":22},[],{"title":967},{"EN":57},[],[970,977],{"id":61,"indexDatabase":971,"url":72,"indexYears":73,"academicFieldIds":976,"indexDatabaseRanking":78},{"id":63,"createTime":22,"updateTime":22,"relativeEntities":972,"label":973,"description":974,"key":69,"publicationTags":975,"standard":22},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75,76,77],{"id":80,"indexDatabase":978,"url":93,"indexYears":22,"academicFieldIds":983,"indexDatabaseRanking":22},{"id":82,"createTime":22,"updateTime":22,"relativeEntities":979,"label":980,"description":981,"key":89,"publicationTags":982,"standard":22},[],{"EN":85,"VI":85},{"EN":87,"VI":88},[91,92],[95,96],{"impactFactor":23,"impactFactorByYear":985,"i10Index":23,"i10IndexLast5Year":23,"totalPublication":100,"totalPublicationByYear":986,"totalCitation":136,"totalCitationByYear":987,"totalCitationPerPublication":23,"totalCitationPerPublicationByYear":988,"hindexLast5Year":138,"hindex":138},{"1989":99,"2014":23,"2021":23},{"1982":102,"1983":103,"1984":104,"1985":105,"1986":106,"1987":107,"1988":108,"1989":107,"1990":109,"1991":110,"1992":111,"1993":112,"1994":113,"1995":114,"1996":111,"1997":115,"1998":111,"1999":115,"2000":116,"2001":117,"2002":118,"2003":119,"2004":120,"2005":121,"2006":122,"2007":123,"2008":124,"2009":118,"2010":125,"2011":126,"2012":127,"2013":128,"2014":129,"2015":130,"2016":131,"2017":130,"2018":132,"2019":127,"2020":133,"2021":112,"2022":134,"2023":135,"2024":102},{"1987":138,"2012":139,"2019":140},{"1987":142,"2012":143,"2019":142},{"pages":990,"volume":992},{"VOID":991},"669-679",{"VOID":993},"42","2023-03-27",[91,78],{"id":997,"createTime":998,"updateTime":999,"relativeEntities":1000,"slug":1001,"properties":1002,"entityType":165,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":1012,"viewCount":23,"primaryUrl":1013,"fullTextUrl":22,"authors":1014,"publicationType":218,"publisherRelationship":1108,"citationCount":22,"citationInfo":22,"publishDate":1164,"publishYear":1165,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":1166,"openAccess":22,"references":22,"isForceReanalyzing":278},"11359abe-6457-4bab-bfa5-fdcd1dbc5bcf","2023-12-26T11:14:36.931+00:00","2026-09-07T11:17:36.273+00:00",[],"Molecular-characterization-of-carbapenem-resistant-Enterobacteriaceae-at-a-tertiary-care-laboratory-in-Mumbai",{"abstract":1003,"title":1005,"references":1008,"doi":1010},{"EN":1004},"Carbapenem-hydrolyzing β-lactamases are increasingly reported worldwide, leading to therapeutic failure. In an era where the drug development pipeline is stagnant, it is crucial to preserve current classes of antibiotics to help fight against infection caused by multidrug-resistant organisms (MDROs), by practicing a rational approach for the use of antibiotics. Identifying the mechanisms of resistance gives us much needed insights in this field. A total of 113 consecutive, non-duplicate carbapenem-resistant clinical isolates were collected from July to December 2012. These isolates were subjected to the modified Hodge test (MHT) for phenotypic detection of carbapenemases, an inhibitor-based test employing EDTA for the detection of metallo-β-lactamase (MBL), and phenylboronic acid for the detection of Klebsiella pneumoniae carbapenemase (KPC). A multiplex polymerase chain reaction (PCR) assay that characterized the five most predominant carbapenemases (bla\n                NDM, bla\n                OXA, bla\n                VIM, bla\n                IMP, bla\n                KPC) was designed. The 113 isolates consisted of Klebsiella spp. (46), Enterobacter spp. (32), Escherichia coli (31), Citrobacter spp. (2), Proteus spp. (1), and Morganella spp. (1). bla\n                NDM-1 was the most prevalent carbapenemase and accounted for 75.22 % (85\u002F113) of the isolates. This was followed by bla\n                OXA [4.42 % (n = 5)]. 18.5 % (21\u002F113) of the isolates possessed dual carbapenemase genes. 98.9 % concordance was observed between the phenotypic tests and the molecular tests for the detection of MBL. In conclusion, patients infected with resistant bacteria require early appropriate antimicrobial treatment for good clinical outcome. Thus, identifying the resistant mechanisms of suspected pathogens becomes crucial. Also, the high incidence of plasmid-mediated bla\n                NDM-1 calls for the implementation of strict infection control and contact isolation precautions in order to prevent the spread of these organisms.",{"EN":1006,"VI":1007},"Molecular characterization of carbapenem-resistant Enterobacteriaceae at a tertiary care laboratory in Mumbai","Đặc trưng phân tử của vi khuẩn Enterobacteriaceae kháng carbapenem tại một phòng xét nghiệm tuyến cuối ở Mumbai",{"VOID":1009},"Tenover FC (2006) Mechanisms of antimicrobial resistance in bacteria. Am J Med 119(6 Suppl 1):S3–S10\nPapp-Wallace KM, Endimiani A, Taracila MA, Bonomo RA (2011) Carbapenems: past, present, and future. Antimicrob Agents Chemother 55(11):4943–4960\nBush K, Jacoby GA (2010) Updated functional classification of β-lactamases. Antimicrob Agents Chemother 54(3):969–976\nNordmann P, Naas T, Poirel L (2011) Global spread of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis 17(10):1791–1798\nUpadhyay S, Sen MR, Bhattacharjee A (2012) Identification and characterization of carbapenem hydrolysing β-lactamase—KPC among enterobacteriaceae: a report from North India. Asian J Med Sci 3:11–15\nQueenan AM, Bush K (2007) Carbapenemases: the versatile β-lactamases. Clin Microbiol Rev 20(3):440–458\nBirgy A, Bidet P, Genel N, Doit C, Decré D, Arlet G et al (2012) Phenotypic screening of carbapenemases and associated β-lactamases in carbapenem-resistant Enterobacteriaceae. J Clin Microbiol 50(4):1295–1302\nClinical and Laboratory Standards Institute (CLSI) (2012) Performance standards for antimicrobial susceptibility testing; twenty-second informational supplement. CLSI document M100-S22\nGalani I, Rekatsina PD, Hatzaki D, Plachouras D, Souli M, Giamarellou H (2008) Evaluation of different laboratory tests for the detection of metallo-beta-lactamase production in Enterobacteriaceae. J Antimicrob Chemother 61(3):548–553\nTsakris A, Poulou A, Pournaras S, Voulgari E, Vrioni G, Themeli-Digalaki K et al (2010) A simple phenotypic method for the differentiation of metallo-β-lactamases and class A KPC carbapenemases in Enterobacteriaceae clinical isolates. J Antimicrob Chemother 65:1664–1671\nDeshpande P, Rodrigues C, Shetty A, Kapadia F, Hedge A, Soman R (2010) New Delhi metallo-b lactamase (NDM-1) in Enterobacteriaceae: treatment options with carbapenems compromised. J Assoc Physicians India 58:147–149\nLahey Clinic. Home page at: http:\u002F\u002Fwww.lahey.org\u002FStudies\nDatta P, Gupta V, Garg S, Chander J (2012) Phenotypic method for differentiation of carbapenemases in Enterobacteriaceae: study from north India. Indian J Pathol Microbiol 55(3):357\nNordmann P, Poirel L (2013) Strategies for identification of carbapenemase-producing Enterobacteriaceae. J Antimicrob Chemother 68(3):487–489\nDoyle D, Peirano G, Lascols C, Lloyd T, Church DL, Pitout JD (2012) Laboratory detection of Enterobacteriaceae that produce carbapenemases. J Clin Microbiol 50(12):3877–3880\nGençer S, Ak O, Benzonana N, Batirel A, Ozer S (2002) Susceptibility patterns and cross resistances of antibiotics against Pseudomonas aeruginosa in a teaching hospital of Turkey. Ann Clin Microbiol Antimicrob 1:2\nPicão RC, Andrade SS, Nicoletti AG, Campana EH, Moraes GC, Mendes RE et al (2008) Metallo-β-lactamase detection: comparative evaluation of double-disk synergy versus combined Disk tests for IMP-, GIM-, SIM-, SPM-, or VIM-producing isolates. J Clin Microbiol 46(6):2028–2037\nFranklin C, Liolios L, Peleg AY (2006) Phenotypic detection of carbapenem-susceptible metallo-beta-lactamase-producing gram-negative bacilli in the clinical laboratory. J Clin Microbiol 44(9):3139–3144\nYong D, Toleman MA, Giske CG, Cho HS, Sundman K, Lee K et al (2009) Characterization of a new metallo-beta-lactamase gene, blaNDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother 53:5046–5054\nBharadwaj R, Joshi S, Dohe V, Gaikwad V, Kulkarni G, Shouche Y (2012) Prevalence of New Delhi metallo-β-lactamase (NDM-1)-positive bacteria in a tertiary care centre in Pune, India. Int J Antimicrob Agents 39(3):265–266\nJovcic B, Lepsanovic Z, Suljagic V, Rackov G, Begovic J, Topisirovic L et al (2011) Emergence of NDM-1 metallo-β-lactamase in pseudomonas aeruginosa clinical isolates from Serbia. Antimicrob Agents Chemother 55(8):3929–3931\nLivermore DM (2012) Current epidemiology and growing resistance of gram-negative pathogens. Korean J Intern Med 27:128–142\nPoirel L, Potron A, Nordmann P (2012) OXA-48-like carbapenemases: the phantom menace. J Antimicrob Chemother 67(7):1597–1606\nPoirel L, Héritier C, Tolün V, Nordmann P (2004) Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae. Antimicrob Agents Chemother 48(1):15–22",{"VOID":1011},"10.1007\u002Fs10096-014-2249-x",[170],"https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs10096-014-2249-x",[1015,1030,1043,1056,1069,1082,1095],{"id":1016,"sortIndex":23,"researcher":22,"roles":1017,"affiliations":1018,"properties":1027,"displayName":1029,"givenName":22,"familyName":22},"1c71e691-f19f-4722-8d47-1bd5a67cea2d",[176],[1019],{"id":1020,"sortIndex":23,"affiliation":1021,"properties":22},"052e610b-fea7-4d87-8f71-ee43a9267f2f",{"id":1020,"createTime":22,"updateTime":22,"relativeEntities":1022,"slug":22,"properties":1023,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1026,"statistic":22},[],{"title":1024},{"VI":1025},"Department of Microbiology, P.D. Hinduja Hospital & Medical Research Centre, Mahim (West), Mumbai, India",[],{"title":1028},{"VI":1029},"M. Kazi",{"id":1031,"sortIndex":191,"researcher":22,"roles":1032,"affiliations":1033,"properties":1040,"displayName":1042,"givenName":22,"familyName":22},"fe1f6678-6c0e-42b9-bb8f-5b9288349f35",[176],[1034],{"id":1020,"sortIndex":23,"affiliation":1035,"properties":22},{"id":1020,"createTime":22,"updateTime":22,"relativeEntities":1036,"slug":22,"properties":1037,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1039,"statistic":22},[],{"title":1038},{"VI":1025},[],{"title":1041},{"VI":1042},"L. Drego",{"id":1044,"sortIndex":138,"researcher":22,"roles":1045,"affiliations":1046,"properties":1053,"displayName":1055,"givenName":22,"familyName":22},"30c9d8f1-7c9f-4d87-ac06-356596f6cee3",[176],[1047],{"id":1020,"sortIndex":23,"affiliation":1048,"properties":22},{"id":1020,"createTime":22,"updateTime":22,"relativeEntities":1049,"slug":22,"properties":1050,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1052,"statistic":22},[],{"title":1051},{"VI":1025},[],{"title":1054},{"VI":1055},"C. Nikam",{"id":1057,"sortIndex":140,"researcher":22,"roles":1058,"affiliations":1059,"properties":1066,"displayName":1068,"givenName":22,"familyName":22},"ae80dc95-4417-418c-9356-453175319612",[176],[1060],{"id":1020,"sortIndex":23,"affiliation":1061,"properties":22},{"id":1020,"createTime":22,"updateTime":22,"relativeEntities":1062,"slug":22,"properties":1063,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1065,"statistic":22},[],{"title":1064},{"VI":1025},[],{"title":1067},{"VI":1068},"K. Ajbani",{"id":1070,"sortIndex":366,"researcher":22,"roles":1071,"affiliations":1072,"properties":1079,"displayName":1081,"givenName":22,"familyName":22},"c2fa47dc-7176-42bf-8c4c-24ebf926a70e",[176],[1073],{"id":1020,"sortIndex":23,"affiliation":1074,"properties":22},{"id":1020,"createTime":22,"updateTime":22,"relativeEntities":1075,"slug":22,"properties":1076,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1078,"statistic":22},[],{"title":1077},{"VI":1025},[],{"title":1080},{"VI":1081},"R. Soman",{"id":1083,"sortIndex":382,"researcher":22,"roles":1084,"affiliations":1085,"properties":1092,"displayName":1094,"givenName":22,"familyName":22},"ce4c3e76-9b4a-4cf9-86d0-350b38ba43c3",[176],[1086],{"id":1020,"sortIndex":23,"affiliation":1087,"properties":22},{"id":1020,"createTime":22,"updateTime":22,"relativeEntities":1088,"slug":22,"properties":1089,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1091,"statistic":22},[],{"title":1090},{"VI":1025},[],{"title":1093},{"VI":1094},"A. Shetty",{"id":1096,"sortIndex":396,"researcher":22,"roles":1097,"affiliations":1098,"properties":1105,"displayName":1107,"givenName":22,"familyName":22},"77873e0b-108e-4c0c-b5db-36d24b5f8414",[176],[1099],{"id":1020,"sortIndex":23,"affiliation":1100,"properties":22},{"id":1020,"createTime":22,"updateTime":22,"relativeEntities":1101,"slug":22,"properties":1102,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1104,"statistic":22},[],{"title":1103},{"VI":1025},[],{"title":1106},{"VI":1107},"C. Rodrigues",{"url":1013,"publisher":1109,"properties":1159},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1110,"slug":10,"properties":1111,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":1115,"manageAffiliations":1128,"indexDatabases":1139,"url":22,"thumbnailPath":22,"statistic":1154,"gsStatistic":22,"type":144,"analyzePriority":22},[],{"issn":1112,"title":1113,"eissn":1114},{"VOID":15},{"EN":17},{"VOID":13},[1116,1120,1124],{"id":26,"createTime":22,"updateTime":22,"relativeEntities":1117,"label":1118,"description":1119,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":29},{},{"id":32,"createTime":22,"updateTime":22,"relativeEntities":1121,"label":1122,"description":1123,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":35},{},{"id":38,"createTime":22,"updateTime":22,"relativeEntities":1125,"label":1126,"description":1127,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":41},{},[1129,1134],{"id":45,"createTime":22,"updateTime":22,"relativeEntities":1130,"slug":22,"properties":1131,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1133,"statistic":22},[],{"title":1132},{"EN":49},[51],{"id":53,"createTime":22,"updateTime":22,"relativeEntities":1135,"slug":22,"properties":1136,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1138,"statistic":22},[],{"title":1137},{"EN":57},[],[1140,1147],{"id":61,"indexDatabase":1141,"url":72,"indexYears":73,"academicFieldIds":1146,"indexDatabaseRanking":78},{"id":63,"createTime":22,"updateTime":22,"relativeEntities":1142,"label":1143,"description":1144,"key":69,"publicationTags":1145,"standard":22},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75,76,77],{"id":80,"indexDatabase":1148,"url":93,"indexYears":22,"academicFieldIds":1153,"indexDatabaseRanking":22},{"id":82,"createTime":22,"updateTime":22,"relativeEntities":1149,"label":1150,"description":1151,"key":89,"publicationTags":1152,"standard":22},[],{"EN":85,"VI":85},{"EN":87,"VI":88},[91,92],[95,96],{"impactFactor":23,"impactFactorByYear":1155,"i10Index":23,"i10IndexLast5Year":23,"totalPublication":100,"totalPublicationByYear":1156,"totalCitation":136,"totalCitationByYear":1157,"totalCitationPerPublication":23,"totalCitationPerPublicationByYear":1158,"hindexLast5Year":138,"hindex":138},{"1989":99,"2014":23,"2021":23},{"1982":102,"1983":103,"1984":104,"1985":105,"1986":106,"1987":107,"1988":108,"1989":107,"1990":109,"1991":110,"1992":111,"1993":112,"1994":113,"1995":114,"1996":111,"1997":115,"1998":111,"1999":115,"2000":116,"2001":117,"2002":118,"2003":119,"2004":120,"2005":121,"2006":122,"2007":123,"2008":124,"2009":118,"2010":125,"2011":126,"2012":127,"2013":128,"2014":129,"2015":130,"2016":131,"2017":130,"2018":132,"2019":127,"2020":133,"2021":112,"2022":134,"2023":135,"2024":102},{"1987":138,"2012":139,"2019":140},{"1987":142,"2012":143,"2019":142},{"pages":1160,"volume":1162},{"VOID":1161},"467-472",{"VOID":1163},"34","2014-09-27",2014,[91,78],{"id":1168,"createTime":1169,"updateTime":1170,"relativeEntities":1171,"slug":1172,"properties":1173,"entityType":165,"verifyStatus":166,"verifyTime":1183,"verifyNote":168,"languages":22,"translateLanguages":1184,"viewCount":23,"primaryUrl":1185,"fullTextUrl":22,"authors":1186,"publicationType":218,"publisherRelationship":1329,"citationCount":22,"citationInfo":22,"publishDate":1384,"publishYear":819,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":1385,"openAccess":22,"references":22,"isForceReanalyzing":278},"31244567-00f9-4667-8c5e-29e0ffeb9ade","2023-12-11T18:08:32.976+00:00","2026-09-07T09:14:42.969+00:00",[],"The-efficacy-of-mesenchymal-stem-cell-treatment-and-colistin-fosfomycin-combination-on-colistin-resistant-Acinetobacter-baumannii-sepsis-model",{"abstract":1174,"title":1176,"references":1179,"doi":1181},{"EN":1175},"This study examines the role of mesenchymal stem cells (MSCs) in an experimental sepsis model developed with colistin-resistant Acinetobacter baumannii (CRAB). BALB-c mice were divided into treatment groups (MSC, MSC + colistin (C)-fosfomycin (F), and C-F and control groups (positive and negative)). CRAB was administered to mice through intraperitoneal injection. Three hours later, C, F, and MSC were given intraperitoneally to the treatment groups. Colistin administration was repeated every 12 h, F administration was done every 4 h, and the second dose of MSC was administered after 48 h. Mice were sacrificed at 24 and 72 h. The bacterial load was determined as colony-forming units per gram (cfu\u002Fg). Histopathological examination was conducted on the left lung, liver, and both kidneys. IL-6 and C-reactive protein (CRP) levels in mouse sera were determined by enzyme-linked immunosorbent assay. Among the treatment groups, the C-F group had the lowest colony count in the lung (1.24 ± 1.66 cfu\u002Fg) and liver (1.03 ± 1.08 cfu\u002Fg). The highest bacterial clearance was observed at 72 h compared to 24 h in the MSC-treated groups (p = 0.008). The MSC + C-F group showed the lowest histopathological score in the liver and kidney (p = 0.009). In the negative control group, the IL-6 level at the 24th hour was the lowest (p \u003C 0.001). Among the treatment groups, the CRP level was the lowest in the MSC + C-F group at 24 and 72 h. In a CRAB sepsis model, adding MSCs to a colistin-fosfomycin treatment may be beneficial in terms of reducing bacterial loads and preventing histopathological damage.",{"EN":1177,"VI":1178},"The efficacy of mesenchymal stem cell treatment and colistin-fosfomycin combination on colistin-resistant Acinetobacter baumannii sepsis model","Hiệu quả của điều trị bằng tế bào gốc trung mô và phối hợp colistin-fosfomycin trên mô hình nhiễm khuẩn huyết do Acinetobacter baumannii kháng colistin",{"VOID":1180},"Gönen ZB, Dinç G, Doğanay M (2020) Mesenchymal stem cell therapy for severe sepsis and septic shock. Erciyes Med J 42(1):1–2. https:\u002F\u002Fdoi.org\u002F10.14744\u002Fetd.2019.35336\nChiu C, Legrand M (2021) Epidemiology of sepsis and septic shock. Curr Opin Anaesthesiol 34(2):71–76. https:\u002F\u002Fdoi.org\u002F10.1097\u002FACO.0000000000000958\nPaul M, Carrara E, Retamar P, Tängdén T, Bitterman R, Bonomo RA et al (2022) European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for the treatment of infections caused by multidrug-resistant Gram-negative bacilli (endorsed by European society of intensive care medicine). Clin Microbiol Infect 28(4):521–547. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.cmi.2021.11.025\nKarakonstantis S, Kritsotakis EI, Gikas A (2020) Pandrug-resistant Gram-negative bacteria: a systematic review of current epidemiology, prognosis and treatment options. J Antimicrob Chemother 75(2):271–282. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjac\u002Fdkz401\nKarakonstantis S, Gikas A, Astrinaki E, Kritsotakis EI, Karakonstantis S, Gikas A et al (2020) Excess mortality due to pandrug-resistant Acinetobacter baumannii infections in hospitalized patients. J Hosp Infect 106(3):447–453. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jhin.2020.09.009\nSaelim W, Changpradub D, Thunyaharn S, Juntanawiwat P, Nulsopapon P, Santimaleeworagun W (2021) Colistin plus sulbactam or fosfomycin against carbapenem-resistant Acinetobacter baumannii: improved efficacy or decreased risk of nephrotoxicity? Infect Chemother 53(1):128–140. https:\u002F\u002Fdoi.org\u002F10.3947\u002Fic.2021.0007\nLeelasupasri S, Santimaleeworagun W, Jitwasinkul T (2018) Antimicrobial susceptibility among colistin, sulbactam, and fosfomycin and a synergism study of colistin in combination with sulbactam or fosfomycin against clinical isolates of carbapenem-resistant Acinetobacter baumannii. J Pathog 2018:3893492. https:\u002F\u002Fdoi.org\u002F10.1155\u002F2018\u002F3893492\nAbdul-Mutakabbir JC, Griffith NC, Shields RK, Tverdek FP, Escobar ZK (2021) Contemporary perspective on the treatment of Acinetobacter baumannii infections: insights from the Society of Infectious Diseases Pharmacists. Infect Dis Ther 10(4):2177–2202. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs40121-021-00541-4\nZheng G, Huang R, Qiu G, Ge M, Wang J, Shu Q et al (2018) Mesenchymal stromal cell-derived extracellular vesicles: regenerative and immunomodulatory effects and potential applications in sepsis. Cell Tissue Res 374(1):1–15\nKeane C, Jerkic M, Laffey JG (2017) Stem cell-based therapies for sepsis. Anesthesiology 127(6):1017–1034. https:\u002F\u002Fdoi.org\u002F10.1097\u002FALN.0000000000001882\nLombardo E, van der Poll T, DelaRosa O, Dalemans W, Lombardo E, van der Poll T et al (2015) Mesenchymal stem cells as a therapeutic tool to treat sepsis. World J Stem Cells 7(2):368–379. https:\u002F\u002Fdoi.org\u002F10.4252\u002Fwjsc.v7.i2.368\nAlp E, Gonen ZB, Gundogan K, Esmaoglu A, Kaynar L, Cetin A et al (2022) The effect of mesenchymal stromal cells on the mortality of patients with sepsis and septic shock: a promising therapy. Emerg Med Int 2022:9222379\nEuropean Committee on Antimicrobial Susceptibility Testing Breakpoint tables for interpretation of MICs and zone diameters Version 12.0, valid from 2022-01-01. https:\u002F\u002Fwww.eucast.org\u002Ffileadmin\u002Fsrc\u002Fmedia\u002FPDFs\u002FEUCAST_files\u002FBreakpoint_tables\u002Fv_12.0_Breakpoint_Tables.pdf. Accessed 02.08.2023\nEryılmaz-Eren E, Dinç G, Kontaş O, Alp E, Doğanay M (2021) The investigation of adrenal involvement in carbapenem resistant Acinetobacter baumannii sepsis: experimental mouse model. Turk J Med Sci 51(6):3108–3114. https:\u002F\u002Fdoi.org\u002F10.3906\u002Fsag-2001-163\nThe Clinical and Laboratory Standards Institute 2020 [İnternet]. [a.yer 27 Şubat 2022]. Erişim adresi. https:\u002F\u002Fwww.nih.org.pk\u002Fwp-content\u002Fuploads\u002F2021\u002F02\u002FCLSI-2020.pdf. Accessed 27 Feb 2022\nKu NS, Lee SH, Soun LY, Choi H, Ahn JY, Jeong SJ et al (2019) In vivo efficacy of combination of colistin with fosfomycin or minocycline in a mouse model of multidrug-resistant Acinetobacter baumannii pneumonia. Sci Rep 9(1):17127. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41598-019-53714-0\nDinc G, Demiraslan H, Elmali F, Ahmed SS, Alp E, Doganay M (2015) Antimicrobial efficacy of doripenem and its combinations with sulbactam, amikacin, colistin, tigecycline in experimental sepsis of carbapenem-resistant Acinetobacter baumannii. New Microbiol 38(1):67–73\nNwabor OF, Terbtothakun P, Voravuthikunchai SP, Chusri S, Nwabor OF, Terbtothakun P et al (2021) Evaluation of the synergistic antibacterial effects of fosfomycin in combination with selected antibiotics against carbapenem-resistant Acinetobacter baumannii. Pharmaceuticals (Basel). 14(3):185. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fph14030185\nSirijatuphat R, Thamlikitkul V, Sirijatuphat R, Thamlikitkul V (2014) Preliminary study of colistin versus colistin plus fosfomycin for treatment of carbapenem-resistant Acinetobacter baumannii infections. Antimicrob Agents Chemother. 58(9):5598–5601. https:\u002F\u002Fdoi.org\u002F10.1128\u002FAAC.02435-13\nMarrazzo P, Crupi AN, Alviano F, Teodori L, Bonsi L (2019) Exploring the roles of MSCs in infections: focus on bacterial diseases. J Mol Med (Berl) 97(4):437–450. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00109-019-01752-6\nAlcayaga-Miranda F, Cuenca J, Martin A, Contreras L, Figueroa FE, Khoury M (2015) Combination therapy of menstrual derived mesenchymal stem cells and antibiotics ameliorates survival in sepsis. Stem Cell Res Ther 6:199\nGalstyan G, Makarova P, Parovichnikova E, Kuzmina L, Troitskaya V et al (2018) The results of the single center pilot randomized Russian Clinical Trial of Mesenchymal Stromal Cells in Severe Neutropenic Patients with Septic Shock (RUMCESS). Int J Blood Res Disord 5:033. https:\u002F\u002Fdoi.org\u002F10.23937\u002F2469-5696\u002F1410033\nFazekas B, Alagesan S, Watson L, Ng O, Conroy CM, Català C et al (2022) Comparison of single and repeated dosing of anti-inflammatory human umbilical cord mesenchymal stromal cells in a mouse model of polymicrobial sepsis. Stem Cell Rev Rep 18(4):1444–1460. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs12015-021-10323-7\nLuo CJ, Zhang FJ, Zhang L, Geng YQ, Li QG, Hong Q et al (2014) Mesenchymal stem cells ameliorate sepsis-associated acute kidney injury in mice. Shock 41(2):123–129. https:\u002F\u002Fdoi.org\u002F10.1097\u002FSHK.0000000000000080\nYang CC, Sung PH, Chen CH, Chiang JY, Shao PL, Wu SC et al (2021) Additional benefit of induced pluripotent stem cell-derived mesenchymal stem cell therapy on sepsis syndrome-associated acute kidney injury in rat treated with antibiotic. Stem Cell Res Ther 12(1):526. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs13287-021-02582-5\nHackstein H, Lippitsch A, Krug P, Schevtschenko I, Kranz S, Hecker M et al (2015) Prospectively defined murine mesenchymal stem cells inhibit Klebsiella pneumoniae-induced acute lung injury and improve pneumonia survival. Respir Res 16:123. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12931-015-0288-1\nDevaney J, Horie S, Masterson C et al (2015) Human mesenchymal stromal cells decrease the severity of acute lung injury induced by E. coli in the rat. Thorax. 70(7):625–635. https:\u002F\u002Fdoi.org\u002F10.1136\u002Fthoraxjnl-2015-206813\nHe X, Ai S, Guo W, Yang Y, Wang Z, Jiang D et al (2018) Umbilical cord-derived mesenchymal stem (stromal) cells for treatment of severe sepsis: aphase 1 clinical trial. Transl Res 199:52–61. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.trsl.2018.04.006\nGonzalez H, Keane C, Masterson CH, Horie S, Elliman SJ, Higgins BD et al (2020) Umbilical cord-derived CD362+ mesenchymal stromal cells attenuate polymicrobial sepsis induced by caecal ligation and puncture. Int J Mol Sci 21(21):8270. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fijms21218270\nPerlee D, de Vos AF, Scicluna BP, Mancheño P, de la Rosa O, Dalemans W et al (2019) Human adipose-derived mesenchymal stem cells modify lung immunity and improve antibacterial defense in pneumosepsis caused by Klebsiella pneumoniae. Stem Cells Transl Med. 8(8):785–796. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fsctm.18-0260\nPetryk N, Shevchenko O (2020) Mesenchymal stem cells anti-inflammatory activity in rats: proinflammatory cytokines. J Inflamm Res 13:293–301. https:\u002F\u002Fdoi.org\u002F10.2147\u002FJIR.S256932",{"VOID":1182},"10.1007\u002Fs10096-023-04674-x","2024-12-20T20:09:24.388+00:00",[170],"https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs10096-023-04674-x",[1187,1202,1217,1232,1247,1262,1275,1290,1303,1316],{"id":1188,"sortIndex":23,"researcher":22,"roles":1189,"affiliations":1190,"properties":1199,"displayName":1201,"givenName":22,"familyName":22},"f383afdd-e3be-4c33-b966-041bb28d90f5",[176],[1191],{"id":1192,"sortIndex":23,"affiliation":1193,"properties":22},"e306a8fe-9395-45b2-9524-ee916b74984c",{"id":1192,"createTime":22,"updateTime":22,"relativeEntities":1194,"slug":22,"properties":1195,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1198,"statistic":22},[],{"title":1196},{"VI":1197},"Department of Infectious Diseases, Çankırı State Hospital, Çankırı, Turkey",[],{"title":1200},{"VI":1201},"Feyza İzci",{"id":1203,"sortIndex":191,"researcher":22,"roles":1204,"affiliations":1205,"properties":1214,"displayName":1216,"givenName":22,"familyName":22},"d82077c2-2077-4ff1-9421-6f75bc92e1c4",[176],[1206],{"id":1207,"sortIndex":23,"affiliation":1208,"properties":22},"5835138f-92aa-46b6-80f0-0194eac55cab",{"id":1207,"createTime":22,"updateTime":22,"relativeEntities":1209,"slug":22,"properties":1210,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1213,"statistic":22},[],{"title":1211},{"VI":1212},"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey",[],{"title":1215},{"VI":1216},"Zeynep Ture",{"id":1218,"sortIndex":138,"researcher":22,"roles":1219,"affiliations":1220,"properties":1229,"displayName":1231,"givenName":22,"familyName":22},"b2e44e87-da39-4ff8-871c-ba6eba6577b4",[176],[1221],{"id":1222,"sortIndex":23,"affiliation":1223,"properties":22},"c5c66173-dc47-4da4-9afd-d4640ab384cf",{"id":1222,"createTime":22,"updateTime":22,"relativeEntities":1224,"slug":22,"properties":1225,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1228,"statistic":22},[],{"title":1226},{"VI":1227},"Department of Medical Microbiology, Faculty of Medicine, and Department of Stem Cell GMP Unit of Genome and Stem Cell Centre, Erciyes University, Kayseri, Turkey",[],{"title":1230},{"VI":1231},"Gokcen Dinc",{"id":1233,"sortIndex":140,"researcher":22,"roles":1234,"affiliations":1235,"properties":1244,"displayName":1246,"givenName":22,"familyName":22},"ecbc1103-4bf3-42cf-a893-8e106e163c79",[176],[1236],{"id":1237,"sortIndex":23,"affiliation":1238,"properties":22},"778ac9f6-81d6-4828-a18d-c49204b9b8c2",{"id":1237,"createTime":22,"updateTime":22,"relativeEntities":1239,"slug":22,"properties":1240,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1243,"statistic":22},[],{"title":1241},{"VI":1242},"Department of Histology and Embryology, Faculty of Medicine, Erciyes University, Kayseri, Turkey",[],{"title":1245},{"VI":1246},"Arzu Hanım Yay",{"id":1248,"sortIndex":366,"researcher":22,"roles":1249,"affiliations":1250,"properties":1259,"displayName":1261,"givenName":22,"familyName":22},"2504bde5-e8b7-4dbf-a8f5-fefb67e5a756",[176],[1251],{"id":1252,"sortIndex":23,"affiliation":1253,"properties":22},"180d6ba4-ca79-4e03-8af1-12ad7bfae284",{"id":1252,"createTime":22,"updateTime":22,"relativeEntities":1254,"slug":22,"properties":1255,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1258,"statistic":22},[],{"title":1256},{"VI":1257},"Department of Infectious Diseases and Clinical Microbiology, Kayseri City Education and Research Hospital, Kayseri, Turkey",[],{"title":1260},{"VI":1261},"Esma Eryılmaz Eren",{"id":1263,"sortIndex":382,"researcher":22,"roles":1264,"affiliations":1265,"properties":1272,"displayName":1274,"givenName":22,"familyName":22},"5616b6c7-7d99-4b04-82e6-428076bccd17",[176],[1266],{"id":1237,"sortIndex":23,"affiliation":1267,"properties":22},{"id":1237,"createTime":22,"updateTime":22,"relativeEntities":1268,"slug":22,"properties":1269,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1271,"statistic":22},[],{"title":1270},{"VI":1242},[],{"title":1273},{"VI":1274},"Demet Bolat",{"id":1276,"sortIndex":396,"researcher":22,"roles":1277,"affiliations":1278,"properties":1287,"displayName":1289,"givenName":22,"familyName":22},"84579b60-d9bc-4046-9a3e-1f61154e6656",[176],[1279],{"id":1280,"sortIndex":23,"affiliation":1281,"properties":22},"8c92b07b-0ed6-4f45-b5ed-c848a535ee0c",{"id":1280,"createTime":22,"updateTime":22,"relativeEntities":1282,"slug":22,"properties":1283,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1286,"statistic":22},[],{"title":1284},{"VI":1285},"Oral and Maxillofacial Surgery, Genome and Stem Cell Center, Erciyes University, Kayseri, Turkey",[],{"title":1288},{"VI":1289},"Zeynep Burcin Gönen",{"id":1291,"sortIndex":412,"researcher":22,"roles":1292,"affiliations":1293,"properties":1300,"displayName":1302,"givenName":22,"familyName":22},"d0c45ad9-024c-4ca2-aa01-5e54dfa40962",[176],[1294],{"id":1207,"sortIndex":23,"affiliation":1295,"properties":22},{"id":1207,"createTime":22,"updateTime":22,"relativeEntities":1296,"slug":22,"properties":1297,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1299,"statistic":22},[],{"title":1298},{"VI":1212},[],{"title":1301},{"VI":1302},"Gamze Kalın Ünüvar",{"id":1304,"sortIndex":665,"researcher":22,"roles":1305,"affiliations":1306,"properties":1313,"displayName":1315,"givenName":22,"familyName":22},"ae50b6d1-63b2-41c9-8826-e55b4cfe28ba",[176],[1307],{"id":1207,"sortIndex":23,"affiliation":1308,"properties":22},{"id":1207,"createTime":22,"updateTime":22,"relativeEntities":1309,"slug":22,"properties":1310,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1312,"statistic":22},[],{"title":1311},{"VI":1212},[],{"title":1314},{"VI":1315},"Orhan Yıldız",{"id":1317,"sortIndex":139,"researcher":22,"roles":1318,"affiliations":1319,"properties":1326,"displayName":1328,"givenName":22,"familyName":22},"a33f9ba2-8c97-4d06-aec1-6aa48e5ffdae",[176],[1320],{"id":1207,"sortIndex":23,"affiliation":1321,"properties":22},{"id":1207,"createTime":22,"updateTime":22,"relativeEntities":1322,"slug":22,"properties":1323,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1325,"statistic":22},[],{"title":1324},{"VI":1212},[],{"title":1327},{"VI":1328},"Bilgehan Aygen",{"url":1185,"publisher":1330,"properties":1380},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1331,"slug":10,"properties":1332,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":1336,"manageAffiliations":1349,"indexDatabases":1360,"url":22,"thumbnailPath":22,"statistic":1375,"gsStatistic":22,"type":144,"analyzePriority":22},[],{"issn":1333,"title":1334,"eissn":1335},{"VOID":15},{"EN":17},{"VOID":13},[1337,1341,1345],{"id":26,"createTime":22,"updateTime":22,"relativeEntities":1338,"label":1339,"description":1340,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":29},{},{"id":32,"createTime":22,"updateTime":22,"relativeEntities":1342,"label":1343,"description":1344,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":35},{},{"id":38,"createTime":22,"updateTime":22,"relativeEntities":1346,"label":1347,"description":1348,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":41},{},[1350,1355],{"id":45,"createTime":22,"updateTime":22,"relativeEntities":1351,"slug":22,"properties":1352,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1354,"statistic":22},[],{"title":1353},{"EN":49},[51],{"id":53,"createTime":22,"updateTime":22,"relativeEntities":1356,"slug":22,"properties":1357,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1359,"statistic":22},[],{"title":1358},{"EN":57},[],[1361,1368],{"id":61,"indexDatabase":1362,"url":72,"indexYears":73,"academicFieldIds":1367,"indexDatabaseRanking":78},{"id":63,"createTime":22,"updateTime":22,"relativeEntities":1363,"label":1364,"description":1365,"key":69,"publicationTags":1366,"standard":22},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75,76,77],{"id":80,"indexDatabase":1369,"url":93,"indexYears":22,"academicFieldIds":1374,"indexDatabaseRanking":22},{"id":82,"createTime":22,"updateTime":22,"relativeEntities":1370,"label":1371,"description":1372,"key":89,"publicationTags":1373,"standard":22},[],{"EN":85,"VI":85},{"EN":87,"VI":88},[91,92],[95,96],{"impactFactor":23,"impactFactorByYear":1376,"i10Index":23,"i10IndexLast5Year":23,"totalPublication":100,"totalPublicationByYear":1377,"totalCitation":136,"totalCitationByYear":1378,"totalCitationPerPublication":23,"totalCitationPerPublicationByYear":1379,"hindexLast5Year":138,"hindex":138},{"1989":99,"2014":23,"2021":23},{"1982":102,"1983":103,"1984":104,"1985":105,"1986":106,"1987":107,"1988":108,"1989":107,"1990":109,"1991":110,"1992":111,"1993":112,"1994":113,"1995":114,"1996":111,"1997":115,"1998":111,"1999":115,"2000":116,"2001":117,"2002":118,"2003":119,"2004":120,"2005":121,"2006":122,"2007":123,"2008":124,"2009":118,"2010":125,"2011":126,"2012":127,"2013":128,"2014":129,"2015":130,"2016":131,"2017":130,"2018":132,"2019":127,"2020":133,"2021":112,"2022":134,"2023":135,"2024":102},{"1987":138,"2012":139,"2019":140},{"1987":142,"2012":143,"2019":142},{"pages":1381,"volume":1383},{"VOID":1382},"1365-1372",{"VOID":993},"2023-10-09",[91,78],{"id":1387,"createTime":1388,"updateTime":1389,"relativeEntities":1390,"slug":1391,"properties":1392,"entityType":165,"verifyStatus":166,"verifyTime":1402,"verifyNote":168,"languages":22,"translateLanguages":1403,"viewCount":23,"primaryUrl":1404,"fullTextUrl":22,"authors":1405,"publicationType":218,"publisherRelationship":1499,"citationCount":22,"citationInfo":22,"publishDate":1555,"publishYear":1556,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":1557,"openAccess":22,"references":22,"isForceReanalyzing":278},"20cab997-acc6-48b1-85db-874e331a3d0d","2024-02-06T02:05:05.345+00:00","2026-09-06T12:14:31.267+00:00",[],"Performance-of-the-BD-Phoenix-CPO-detect-assay-for-detection-and-classification-of-carbapenemase-producing-organisms",{"abstract":1393,"title":1395,"references":1398,"doi":1400},{"EN":1394},"Increasing worldwide, prevalence of carbapenem-resistant gram-negative bacteria demands urgent a need for rapid detection and accurate identification of carbapenemases. The BD Phoenix CPO detect (PCD) assay possesses an in-built capacity for parallel susceptibility testing and detection of carbapenemases. Here, the ability of the assay to detect and classify carbapenemase production was tested in a collection of carbapenem-resistant Enterobacterales and non-fermentative gram-negative rods. The ability of the PCD assay to detect and classify carbapenemases was investigated in a collection of 194 clinical, carbapenem-resistant isolates (Enterobacterales [n = 65]; non-fermentative gram-negative rods [n = 129]). AST results were compared to MICS determined by gradient diffusion to determine accuracy of the PCD assay. The accuracy of the PCD assay to detect carbapenemases was compared to the results of molecular isolate characterization using a LDT multiplex carbapenemase PCR assay. All 194 isolates classified as carbapenem-resistant by reference susceptibility testing were also classified correctly as CRO by the PCD assay. Performance analysis of the PCD assay to detect carbapenemase production revealed an overall sensitivity of 98.29% and specificity of 17.95% for the detection of carbapenemase production. For the classification of carbapenemases classes A, B, and D, the PCD correctly classified 79.17% Enterobacterales and 67.16% non-fermentative gram-negative rods. The PCD assay is a reliable tool for the detection of carbapenem resistance and allows for parallel analysis of carbapenemase production. However, while sensitivity is high, low specificity in carbapenemase detection and erroneous classification demands mandatory confirmation by alternative methods, especially in non-fermentative gram-negative bacteria.",{"EN":1396,"VI":1397},"Performance of the BD Phoenix CPO detect assay for detection and classification of carbapenemase-producing organisms","Hiệu năng của xét nghiệm BD Phoenix CPO Detect trong việc phát hiện và phân loại các vi sinh vật sinh carbapenemase",{"VOID":1399},"Grundmann H, Glasner C, Albiger B, Aanensen DM, Tomlinson CT, Andrasevic AT, Canton R, Carmeli Y, Friedrich AW, Giske CG, Glupczynski Y, Gniadkowski M, Livermore DM, Nordmann P, Poirel L, Rossolini GM, Seifert H, Vatopoulos A, Walsh T, Woodford N, Monnet DL, G. European Survey of Carbapenemase-Producing Enterobacteriaceae Working (2017) Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational study. Lancet Infect Dis 17(2):153–163\nHo J, Tambyah PA, Paterson DL (2010) Multiresistant Gram-negative infections: a global perspective. Curr Opin Infect Dis 23(6):546–553\nBonomo RA, Burd EM, Conly J, Limbago BM, Poirel L, Segre JA, Westblade LF (2018) Carbapenemase-producing organisms: a global scourge. Clin Infect Dis 66(8):1290–1297\nCassini A, Hogberg LD, Plachouras D, Quattrocchi A, Hoxha A, Simonsen GS, Colomb-Cotinat M, Kretzschmar ME, Devleesschauwer B, Cecchini M, Ouakrim DA, Oliveira TC, Struelens MJ, Suetens C, Monnet DL, A. M. R. C. G. Burden of (2019) Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis. Lancet Infect Dis 19(1):56–66\nHughes J, Goldenberg SD, Tosas O, Edgeworth JD, Otter JA (2016) Recent emergence of carbapenem-resistant organisms in a low prevalence UK setting in London. J Infect Prev 17(3):130–134\nCai B, Echols R, Magee G, Arjona Ferreira JC, Morgan G, Ariyasu M, Sawada T, Nagata TD (2017) Prevalence of carbapenem-resistant gram-negative infections in the United States predominated by Acinetobacter baumannii and Pseudomonas aeruginosa. Open Forum Infect Dis 4(3):ofx176\nCodjoe FS, Donkor ES (2017) Carbapenem resistance: a review. Med Sci (Basel) 6(1):1\nThomson G, Turner D, Brasso W, Kircher S, Guillet T, Thomson K (2017) High-stringency evaluation of the automated BD Phoenix CPO detect and Rapidec Carba NP tests for detection and classification of carbapenemases. J Clin Microbiol 55(12):3437–3443\nAmbler RP (1980) The structure of beta-lactamases. Philos Trans R Soc Lond Ser B Biol Sci 289(1036):321–331\nBush K, Bradford PA (2019) Interplay between beta-lactamases and new beta-lactamase inhibitors. Nat Rev Microbiol 17(5):295–306\nSheu CC, Chang YT, Lin SY, Chen YH, Hsueh PR (2019) Infections caused by carbapenem-resistant Enterobacteriaceae: an update on therapeutic options. Front Microbiol 10:80\nWong D, van Duin D (2017) Novel beta-lactamase inhibitors: unlocking their potential in therapy. Drugs 77(6):615–628\nTamma PD, Simner PJ (2018) Phenotypic detection of carbapenemase-producing organisms from clinical isolates. J Clin Microbiol 56(11):e01140-18\nTamma PD, Opene BN, Gluck A, Chambers KK, Carroll KC, Simner PJ (2017) Comparison of 11 phenotypic assays for accurate detection of carbapenemase-producing Enterobacteriaceae. J Clin Microbiol 55(4):1046–1055\nMonteiro J, Widen RH, Pignatari AC, Kubasek C, Silbert S (2012) Rapid detection of carbapenemase genes by multiplex real-time PCR. J Antimicrob Chemother 67(4):906–909\nPoirel L, Walsh TR, Cuvillier V, Nordmann P (2011) Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis 70(1):119–123\nvan der Zee A, Roorda L, Bosman G, Ossewaarde JM (2014) Screening rectal swabs for carbapenemase genes. J Clin Microbiol 52(12):4401–4403\nBecker L, Kaase M, Pfeifer Y, Fuchs S, Reuss A, von Laer A, Sin MA, Korte-Berwanger M, Gatermann S, Werner G (2018) Genome-based analysis of carbapenemase-producing Klebsiella pneumoniae isolates from German hospital patients, 2008-2014. Antimicrob Resist Infect Control 7:62\nNordmann P, Poirel L (2019) Epidemiology and diagnostics of carbapenem resistance in gram-negative bacteria. Clin Infect Dis 69(Suppl 7):S521–S528\nWoodford N, Ellington MJ, Coelho JM, Turton JF, Ward ME, Brown S, Amyes SG, Livermore DM (2006) Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. Int J Antimicrob Agents 27(4):351–353\nvan der Zwaluw K, de Haan A, Pluister GN, Bootsma HJ, de Neeling AJ, Schouls LM (2015) The carbapenem inactivation method (CIM), a simple and low-cost alternative for the Carba NP test to assess phenotypic carbapenemase activity in gram-negative rods. PLoS One 10(3):e0123690\nDe Angelis G, Del Giacomo P, Posteraro B, Sanguinetti M, Tumbarello M (2020) Molecular mechanisms, epidemiology, and clinical importance of beta-lactam resistance in Enterobacteriaceae. Int J Mol Sci 21(14):5090\nPapp-Wallace KM (2019) The latest advances in beta-lactam\u002Fbeta-lactamase inhibitor combinations for the treatment of Gram-negative bacterial infections. Expert Opin Pharmacother 20(17):2169–2184\nHall BG, Barlow M (2005) Revised Ambler classification of {beta}-lactamases. J Antimicrob Chemother 55(6):1050–1051\nOng CH, Ratnayake L, Ang MLT, Lin RTP, Chan DSG (2018) Diagnostic accuracy of BD Phoenix CPO detect for carbapenemase production in 190 Enterobacteriaceae isolates. J Clin Microbiol 56(12):e01043-18\nSimon M, Gatermann S, Pfeifer Y, Reischl U, Gessner A, Jantsch J (2019) Evaluation of the automated BD Phoenix CPO Detect panel in combination with the beta-CARBA assay for detection and classification of carbapenemase-producing Enterobacterales. J Microbiol Methods 156:29–33\nCroxatto A, Coste AT, Pillonel T, Bertelli C, Greub G, Prod'hom G (2020) Evaluation of the BD Phoenix CPO Detect Test for the detection of carbapenemase producers. Clin Microbiol Infect 26(5):644 e649–644 e615\nSaad Albichr I, Anantharajah A, Dodemont M, Hallin M, Verroken A, Rodriguez-Villalobos H (2020) Evaluation of the automated BD Phoenix CPO detect test for detection and classification of carbapenemases in Gram negatives. Diagn Microbiol Infect Dis 96(2):114911\nHoward JC, Creighton J, Ikram R, Werno AM (2020) Comparison of the performance of three variations of the carbapenem inactivation method (CIM, modified CIM [mCIM] and in-house method (iCIM)) for the detection of carbapenemase-producing Enterobacterales and non-fermenters. J Glob Antimicrob Resist 21:78–82\nNoel A, Huang TD, Berhin C, Hoebeke M, Bouchahrouf W, Yunus S, Bogaerts P, Glupczynski Y (2017) Comparative evaluation of four phenotypic tests for detection of carbapenemase-producing gram-negative bacteria. J Clin Microbiol 55(2):510–518\nThomson KS (2010) Extended-spectrum-beta-lactamase, AmpC, and carbapenemase issues. J Clin Microbiol 48(4):1019–1025\nDe Rosa A, Mutters NT, Mastroianni CM, Kaiser SJ, Gunther F (2019) Distribution of carbapenem resistance mechanisms in clinical isolates of XDR Pseudomonas aeruginosa. Eur J Clin Microbiol Infect Dis 38(8):1547–1552\nKaase M, Schimanski S, Schiller R, Beyreiss B, Thurmer A, Steinmann J, Kempf VA, Hess C, Sobottka I, Fenner I, Ziesing S, Burckhardt I, von Muller L, Hamprecht A, Tammer I, Wantia N, Becker K, Holzmann T, Furitsch M, Volmer G, Gatermann SG (2016) Multicentre investigation of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in German hospitals. Int J Med Microbiol 306(6):415–420\nKresken M, Korber-Irrgang B, Korte-Berwanger M, Pfennigwerth N, Gatermann SG, Seifert H, G. German Carbapenem Resistance Study (2020) Dissemination of carbapenem-resistant Pseudomonas aeruginosa isolates and their susceptibilities to ceftolozane-tazobactam in Germany. Int J Antimicrob Agents 55(6):105959\nSchafer E, Malecki M, Tellez-Castillo CJ, Pfennigwerth N, Marlinghaus L, Higgins PG, Mattner F, Wendel AF (2019) Molecular surveillance of carbapenemase-producing Pseudomonas aeruginosa at three medical centres in Cologne, Germany. Antimicrob Resist Infect Control 8:208\nBernabeu S, Dortet L, Naas T (2017) Evaluation of the beta-CARBA test, a colorimetric test for the rapid detection of carbapenemase activity in Gram-negative bacilli. J Antimicrob Chemother 72(6):1646–1658\nMaurer FP, Christner M, Hentschke M, Rohde H (2017) Advances in rapid identification and susceptibility testing of bacteria in the clinical microbiology laboratory: implications for patient care and antimicrobial stewardship programs. Infect Dis Rep 9(1):6839",{"VOID":1401},"10.1007\u002Fs10096-020-04094-1","2024-12-09T23:30:54.911+00:00",[170],"https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs10096-020-04094-1",[1406,1421,1434,1447,1460,1473,1486],{"id":1407,"sortIndex":23,"researcher":22,"roles":1408,"affiliations":1409,"properties":1418,"displayName":1420,"givenName":22,"familyName":22},"9943d2f6-f1eb-4fc7-bbc2-75a762b7c2ca",[176],[1410],{"id":1411,"sortIndex":23,"affiliation":1412,"properties":22},"b3b1e41f-c27f-4b12-9268-be5e4c8b92b1",{"id":1411,"createTime":22,"updateTime":22,"relativeEntities":1413,"slug":22,"properties":1414,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1417,"statistic":22},[],{"title":1415},{"VI":1416},"Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany",[],{"title":1419},{"VI":1420},"Laura Berneking",{"id":1422,"sortIndex":191,"researcher":22,"roles":1423,"affiliations":1424,"properties":1431,"displayName":1433,"givenName":22,"familyName":22},"1ed23c49-10fb-48f4-9db3-a535a698553e",[176],[1425],{"id":1411,"sortIndex":23,"affiliation":1426,"properties":22},{"id":1411,"createTime":22,"updateTime":22,"relativeEntities":1427,"slug":22,"properties":1428,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1430,"statistic":22},[],{"title":1429},{"VI":1416},[],{"title":1432},{"VI":1433},"Anna Both",{"id":1435,"sortIndex":138,"researcher":22,"roles":1436,"affiliations":1437,"properties":1444,"displayName":1446,"givenName":22,"familyName":22},"238323fe-01e0-40cd-bd1d-fce4b1879ea3",[176],[1438],{"id":1411,"sortIndex":23,"affiliation":1439,"properties":22},{"id":1411,"createTime":22,"updateTime":22,"relativeEntities":1440,"slug":22,"properties":1441,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1443,"statistic":22},[],{"title":1442},{"VI":1416},[],{"title":1445},{"VI":1446},"Benjamin Berinson",{"id":1448,"sortIndex":140,"researcher":22,"roles":1449,"affiliations":1450,"properties":1457,"displayName":1459,"givenName":22,"familyName":22},"25a96750-1eef-41c6-adac-65abfe1f24e7",[176],[1451],{"id":1411,"sortIndex":23,"affiliation":1452,"properties":22},{"id":1411,"createTime":22,"updateTime":22,"relativeEntities":1453,"slug":22,"properties":1454,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1456,"statistic":22},[],{"title":1455},{"VI":1416},[],{"title":1458},{"VI":1459},"Armin Hoffmann",{"id":1461,"sortIndex":366,"researcher":22,"roles":1462,"affiliations":1463,"properties":1470,"displayName":1472,"givenName":22,"familyName":22},"d555d38d-3cef-4f6f-a777-d2540a50119e",[176],[1464],{"id":1411,"sortIndex":23,"affiliation":1465,"properties":22},{"id":1411,"createTime":22,"updateTime":22,"relativeEntities":1466,"slug":22,"properties":1467,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1469,"statistic":22},[],{"title":1468},{"VI":1416},[],{"title":1471},{"VI":1472},"Marc Lütgehetmann",{"id":1474,"sortIndex":382,"researcher":22,"roles":1475,"affiliations":1476,"properties":1483,"displayName":1485,"givenName":22,"familyName":22},"429a9b22-d076-4995-947d-dc3d40ef1b22",[176],[1477],{"id":1411,"sortIndex":23,"affiliation":1478,"properties":22},{"id":1411,"createTime":22,"updateTime":22,"relativeEntities":1479,"slug":22,"properties":1480,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1482,"statistic":22},[],{"title":1481},{"VI":1416},[],{"title":1484},{"VI":1485},"Martin Aepfelbacher",{"id":1487,"sortIndex":396,"researcher":22,"roles":1488,"affiliations":1489,"properties":1496,"displayName":1498,"givenName":22,"familyName":22},"e31f4352-6e14-43a2-8642-0fcbe66fbfb1",[176],[1490],{"id":1411,"sortIndex":23,"affiliation":1491,"properties":22},{"id":1411,"createTime":22,"updateTime":22,"relativeEntities":1492,"slug":22,"properties":1493,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1495,"statistic":22},[],{"title":1494},{"VI":1416},[],{"title":1497},{"VI":1498},"Holger Rohde",{"url":1404,"publisher":1500,"properties":1550},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1501,"slug":10,"properties":1502,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":1506,"manageAffiliations":1519,"indexDatabases":1530,"url":22,"thumbnailPath":22,"statistic":1545,"gsStatistic":22,"type":144,"analyzePriority":22},[],{"issn":1503,"title":1504,"eissn":1505},{"VOID":15},{"EN":17},{"VOID":13},[1507,1511,1515],{"id":26,"createTime":22,"updateTime":22,"relativeEntities":1508,"label":1509,"description":1510,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":29},{},{"id":32,"createTime":22,"updateTime":22,"relativeEntities":1512,"label":1513,"description":1514,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":35},{},{"id":38,"createTime":22,"updateTime":22,"relativeEntities":1516,"label":1517,"description":1518,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":41},{},[1520,1525],{"id":45,"createTime":22,"updateTime":22,"relativeEntities":1521,"slug":22,"properties":1522,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1524,"statistic":22},[],{"title":1523},{"EN":49},[51],{"id":53,"createTime":22,"updateTime":22,"relativeEntities":1526,"slug":22,"properties":1527,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1529,"statistic":22},[],{"title":1528},{"EN":57},[],[1531,1538],{"id":61,"indexDatabase":1532,"url":72,"indexYears":73,"academicFieldIds":1537,"indexDatabaseRanking":78},{"id":63,"createTime":22,"updateTime":22,"relativeEntities":1533,"label":1534,"description":1535,"key":69,"publicationTags":1536,"standard":22},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75,76,77],{"id":80,"indexDatabase":1539,"url":93,"indexYears":22,"academicFieldIds":1544,"indexDatabaseRanking":22},{"id":82,"createTime":22,"updateTime":22,"relativeEntities":1540,"label":1541,"description":1542,"key":89,"publicationTags":1543,"standard":22},[],{"EN":85,"VI":85},{"EN":87,"VI":88},[91,92],[95,96],{"impactFactor":23,"impactFactorByYear":1546,"i10Index":23,"i10IndexLast5Year":23,"totalPublication":100,"totalPublicationByYear":1547,"totalCitation":136,"totalCitationByYear":1548,"totalCitationPerPublication":23,"totalCitationPerPublicationByYear":1549,"hindexLast5Year":138,"hindex":138},{"1989":99,"2014":23,"2021":23},{"1982":102,"1983":103,"1984":104,"1985":105,"1986":106,"1987":107,"1988":108,"1989":107,"1990":109,"1991":110,"1992":111,"1993":112,"1994":113,"1995":114,"1996":111,"1997":115,"1998":111,"1999":115,"2000":116,"2001":117,"2002":118,"2003":119,"2004":120,"2005":121,"2006":122,"2007":123,"2008":124,"2009":118,"2010":125,"2011":126,"2012":127,"2013":128,"2014":129,"2015":130,"2016":131,"2017":130,"2018":132,"2019":127,"2020":133,"2021":112,"2022":134,"2023":135,"2024":102},{"1987":138,"2012":139,"2019":140},{"1987":142,"2012":143,"2019":142},{"pages":1551,"volume":1553},{"VOID":1552},"979-985",{"VOID":1554},"40","2020-11-27",2020,[91,78],{"id":1559,"createTime":1560,"updateTime":1561,"relativeEntities":1562,"slug":1563,"properties":1564,"entityType":165,"verifyStatus":166,"verifyTime":1578,"verifyNote":168,"languages":1579,"translateLanguages":1581,"viewCount":23,"primaryUrl":1582,"fullTextUrl":22,"authors":1583,"publicationType":218,"publisherRelationship":1666,"citationCount":23,"citationInfo":1717,"publishDate":22,"publishYear":22,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":1719,"openAccess":22,"references":1720,"isForceReanalyzing":278},"5b688708-4b4d-4845-a56d-9d702ae07f87","2024-04-11T16:21:21.459+00:00","2026-09-05T07:11:14.572+00:00",[],"Interplay-between-IncF-plasmids-and-topoisomerase-mutations-conferring-quinolone-resistance-in-the-Escherichia-coli-ST131-clone-stability-and-resistance-evolution",{"openalex":1565,"mag":1567,"abstract":1569,"title":1571,"pm":1574,"doi":1576},{"VOID":1566},"W3212281253",{"VOID":1568},"3212281253",{"EN":1570},"\u003Cjats:title>Abstract\n\u003C\u002Fjats:title>\u003Cjats:p>The \u003Cjats:italic>Escherichia coli\u003C\u002Fjats:italic> ST131 \u003Cjats:italic>H30\u003C\u002Fjats:italic>-Rx subclone vehicles CTX-M-15 plasmids and mutations in \u003Cjats:italic>gyrA\u003C\u002Fjats:italic> and \u003Cjats:italic>parC\u003C\u002Fjats:italic> conferring multidrug resistance successfully in the clinical setting. The aim of this study was (1) to investigate the relationship of specific topoisomerase mutations on the stability of IncF (CTX-M producing) plasmids using isogenic \u003Cjats:italic>E. coli\u003C\u002Fjats:italic> mutants and (2) to investigate the impact of the IncF-type plasmids present in the \u003Cjats:italic>E. coli\u003C\u002Fjats:italic> clone ST131 on the evolution of quinolone resistance. \u003Cjats:italic>E. coli\u003C\u002Fjats:italic> ATCC 25922 (background strain) and derived mutants encoding specific QRDR substitutions were used. Also, NGS-characterized IncFIA and IncFIB plasmids (encoding CTX-M genes) were included. Plasmid stability was evaluated by sequential dilutions into Luria broth medium without antibiotics for 7 days. Mutant frequency to ciprofloxacin was also evaluated. Moderate differences in the IncF plasmids stability were observed among \u003Cjats:italic>E. coli\u003C\u002Fjats:italic> ATCC 25922 and isogenic mutants. Under our experimental conditions, the fluctuation of bacteria harboring plasmids was less than 0.5-log\u003Cjats:sub>(10)\u003C\u002Fjats:sub> in all cases. In the mutant frequency tests, it was observed that the presence of these IncF plasmids increased this value significantly (10–1000-fold). Quinolone resistance substitutions in \u003Cjats:italic>gyrA\u003C\u002Fjats:italic> or \u003Cjats:italic>parC\u003C\u002Fjats:italic> genes, frequently found associated with \u003Cjats:italic>E. coli\u003C\u002Fjats:italic> clone ST131, do not modify the stability of ST131-associated IncFIA and IncFIB plasmids under \u003Cjats:italic>in vitro\u003C\u002Fjats:italic> conditions. IncF-type plasmids present in \u003Cjats:italic>E. coli\u003C\u002Fjats:italic> clone ST131 facilitate the selection of resistance to quinolones. These results are consistent with the clinical scenario in which the combination of resistance to quinolones and beta-lactams is highly frequent in the \u003Cjats:italic>E. coli\u003C\u002Fjats:italic> clone ST131.\u003C\u002Fjats:p>",{"EN":1572,"VI":1573},"Interplay between IncF plasmids and topoisomerase mutations conferring quinolone resistance in the Escherichia coli ST131 clone: stability and resistance evolution","Tác động qua lại giữa các plasmid IncF và các đột biến topoisomerase tạo ra tính kháng quinolone ở dòng vô tính Escherichia coli ST131: độ ổn định và tiến hóa tính kháng",{"VOID":1575},"34787748",{"VOID":1577},"10.1007\u002Fs10096-021-04358-4","2025-01-31T16:11:58.456+00:00",[1580],"EN",[170],"https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs10096-021-04358-4",[1584,1603,1620,1635,1650],{"id":1585,"sortIndex":23,"researcher":22,"roles":1586,"affiliations":1587,"properties":1596,"displayName":1600,"givenName":22,"familyName":22},"dab30dc6-c81c-4dca-aa4c-29bdbf033769",[],[1588],{"id":1589,"sortIndex":23,"affiliation":1590,"properties":22},"cdb19fd9-b2c8-4fc7-80ef-c03500d591f1",{"id":1589,"createTime":22,"updateTime":22,"relativeEntities":1591,"slug":22,"properties":1592,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1595,"statistic":22},[],{"title":1593},{"EN":1594},"Departamento de Microbiología, Universidad de Sevilla, Avda Sanchez Pizjuan s\u002Fn. 41009, Seville, Spain",[],{"orcid":1597,"title":1599,"openalex":1601},{"VOID":1598},"https:\u002F\u002Forcid.org\u002F0000-0002-2228-2294",{"EN":1600},"José Manuel Rodríguez-Martínez",{"VOID":1602},"A5081339170",{"id":1604,"sortIndex":191,"researcher":22,"roles":1605,"affiliations":1606,"properties":1613,"displayName":1617,"givenName":22,"familyName":22},"1c820176-ac89-43d8-87e6-6ddfb027b194",[],[1607],{"id":1589,"sortIndex":23,"affiliation":1608,"properties":22},{"id":1589,"createTime":22,"updateTime":22,"relativeEntities":1609,"slug":22,"properties":1610,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1612,"statistic":22},[],{"title":1611},{"EN":1594},[],{"orcid":1614,"title":1616,"openalex":1618},{"VOID":1615},"https:\u002F\u002Forcid.org\u002F0000-0001-8950-4384",{"EN":1617},"Lorena López-Cerero",{"VOID":1619},"A5080263211",{"id":1621,"sortIndex":138,"researcher":22,"roles":1622,"affiliations":1623,"properties":1630,"displayName":1632,"givenName":22,"familyName":22},"ac6acb5b-9017-438f-bca1-6c9ce833c581",[],[1624],{"id":1589,"sortIndex":23,"affiliation":1625,"properties":22},{"id":1589,"createTime":22,"updateTime":22,"relativeEntities":1626,"slug":22,"properties":1627,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1629,"statistic":22},[],{"title":1628},{"EN":1594},[],{"title":1631,"openalex":1633},{"EN":1632},"A García-Duque",{"VOID":1634},"A5052396157",{"id":1636,"sortIndex":140,"researcher":22,"roles":1637,"affiliations":1638,"properties":1645,"displayName":1647,"givenName":22,"familyName":22},"72693c92-e2c5-440f-8e0b-e15fcd72fcd2",[],[1639],{"id":1589,"sortIndex":23,"affiliation":1640,"properties":22},{"id":1589,"createTime":22,"updateTime":22,"relativeEntities":1641,"slug":22,"properties":1642,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1644,"statistic":22},[],{"title":1643},{"EN":1594},[],{"title":1646,"openalex":1648},{"EN":1647},"Jesús Rodríguez‐Baño",{"VOID":1649},"A5005399835",{"id":1651,"sortIndex":366,"researcher":22,"roles":1652,"affiliations":1653,"properties":1662,"displayName":685,"givenName":22,"familyName":22},"10a38bea-0fac-49d8-94bf-bb5d21de481c",[],[1654],{"id":1655,"sortIndex":23,"affiliation":1656,"properties":22},"d0a89688-3f2b-4672-a700-a2b44c0c5f25",{"id":1655,"createTime":22,"updateTime":22,"relativeEntities":1657,"slug":22,"properties":1658,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1661,"statistic":22},[],{"title":1659},{"VI":1660},"Instituto de Biomedicina de Sevilla IBIS, Hospital Universitario Virgen Macarena\u002FCSIC\u002FUniversidad de Sevilla, Seville, Spain",[],{"title":1663,"openalex":1664},{"EN":685},{"VOID":1665},"A5057411200",{"url":22,"publisher":1667,"properties":22},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1668,"slug":10,"properties":1669,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":1673,"manageAffiliations":1686,"indexDatabases":1697,"url":22,"thumbnailPath":22,"statistic":1712,"gsStatistic":22,"type":144,"analyzePriority":22},[],{"issn":1670,"title":1671,"eissn":1672},{"VOID":15},{"EN":17},{"VOID":13},[1674,1678,1682],{"id":26,"createTime":22,"updateTime":22,"relativeEntities":1675,"label":1676,"description":1677,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":29},{},{"id":32,"createTime":22,"updateTime":22,"relativeEntities":1679,"label":1680,"description":1681,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":35},{},{"id":38,"createTime":22,"updateTime":22,"relativeEntities":1683,"label":1684,"description":1685,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":41},{},[1687,1692],{"id":45,"createTime":22,"updateTime":22,"relativeEntities":1688,"slug":22,"properties":1689,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1691,"statistic":22},[],{"title":1690},{"EN":49},[51],{"id":53,"createTime":22,"updateTime":22,"relativeEntities":1693,"slug":22,"properties":1694,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1696,"statistic":22},[],{"title":1695},{"EN":57},[],[1698,1705],{"id":61,"indexDatabase":1699,"url":72,"indexYears":73,"academicFieldIds":1704,"indexDatabaseRanking":78},{"id":63,"createTime":22,"updateTime":22,"relativeEntities":1700,"label":1701,"description":1702,"key":69,"publicationTags":1703,"standard":22},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75,76,77],{"id":80,"indexDatabase":1706,"url":93,"indexYears":22,"academicFieldIds":1711,"indexDatabaseRanking":22},{"id":82,"createTime":22,"updateTime":22,"relativeEntities":1707,"label":1708,"description":1709,"key":89,"publicationTags":1710,"standard":22},[],{"EN":85,"VI":85},{"EN":87,"VI":88},[91,92],[95,96],{"impactFactor":23,"impactFactorByYear":1713,"i10Index":23,"i10IndexLast5Year":23,"totalPublication":100,"totalPublicationByYear":1714,"totalCitation":136,"totalCitationByYear":1715,"totalCitationPerPublication":23,"totalCitationPerPublicationByYear":1716,"hindexLast5Year":138,"hindex":138},{"1989":99,"2014":23,"2021":23},{"1982":102,"1983":103,"1984":104,"1985":105,"1986":106,"1987":107,"1988":108,"1989":107,"1990":109,"1991":110,"1992":111,"1993":112,"1994":113,"1995":114,"1996":111,"1997":115,"1998":111,"1999":115,"2000":116,"2001":117,"2002":118,"2003":119,"2004":120,"2005":121,"2006":122,"2007":123,"2008":124,"2009":118,"2010":125,"2011":126,"2012":127,"2013":128,"2014":129,"2015":130,"2016":131,"2017":130,"2018":132,"2019":127,"2020":133,"2021":112,"2022":134,"2023":135,"2024":102},{"1987":138,"2012":139,"2019":140},{"1987":142,"2012":143,"2019":142},{"total":23,"publishYear":22,"statisticByYear":1718},{},[],[1721,1725,1729,1733,1737,1741,1745,1749,1753,1757,1761,1765,1769,1772,1776,1780,1784,1787,1791,1795,1799,1803,1807,1811],{"id":22,"text":1722,"url":22,"identifiers":1723},"Pitout JDD (2012) Extraintestinal pathogenic Escherichia coli: an update on antimicrobial resistance, laboratory diagnosis and treatment. Expert Rev. Anti. Infect. Ther. 10:1165–76. http:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpubmed\u002F23199402https:\u002F\u002Fdoi.org\u002F10.1586\u002Feri.12.110",{"doi":1724},"10.1586\u002Feri.12.110",{"id":22,"text":1726,"url":22,"identifiers":1727},"Nicolas-Chanoine M-H, Bertrand X, Madec J-Y (2014) Escherichia coli ST131, an intriguing clonal group. Clin. Microbiol. Rev. 27:543–74. http:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpubmed\u002F24982321https:\u002F\u002Fdoi.org\u002F10.1128\u002FCMR.00125-13",{"doi":1728},"10.1128\u002FCMR.00125-13",{"id":22,"text":1730,"url":22,"identifiers":1731},"Petty NK, Ben Zakour NL, Stanton-Cook M, Skippington E, Totsika M, Forde BM, et al (2014) Global dissemination of a multidrug resistant Escherichia coli clone. Proc. Natl. Acad. Sci. U. S. A. 15;111:5694–9. http:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpubmed\u002F24706808https:\u002F\u002Fdoi.org\u002F10.1073\u002Fpnas.1322678111",{"doi":1732},"10.1073\u002Fpnas.1322678111",{"id":22,"text":1734,"url":22,"identifiers":1735},"Ben Zakour NL, Alsheikh-Hussain AS, Ashcroft MM, Khanh Nhu NT, Roberts LW, Stanton-Cook M, et al (2016) Sequential acquisition of virulence and fluoroquinolone resistance has shaped the evolution of Escherichia coli ST131. MBio 26;7:e00347–16.http:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpubmed\u002F27118589https:\u002F\u002Fdoi.org\u002F10.1128\u002FmBio.00347-16",{"doi":1736},"10.1128\u002FmBio.00347-16",{"id":22,"text":1738,"url":22,"identifiers":1739},"Stoesser N, Sheppard AE, Pankhurst L, De Maio N, Moore CE, Sebra R, et al (2016) Evolutionary history of the global emergence of the Escherichia coli epidemic clone ST131. MBio 22;7:e02162. http:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpubmed\u002F27006459https:\u002F\u002Fdoi.org\u002F10.1128\u002FmBio.02162-15",{"doi":1740},"10.1128\u002FmBio.02162-15",{"id":22,"text":1742,"url":22,"identifiers":1743},"Pitout JDD, Finn TJ (2020) The evolutionary puzzle of Escherichia coli ST131. Infect. Genet. Evol. 81:104265. http:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpubmed\u002F32112974https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.meegid.2020.104265",{"doi":1744},"10.1016\u002Fj.meegid.2020.104265",{"id":22,"text":1746,"url":22,"identifiers":1747},"Matsumura Y, Pitout JDD, Gomi R, Matsuda T, Noguchi T, Yamamoto M, et al (2016) Global Escherichia coli sequence type 131 clade with blaCTX-M-27 gene. Emerg. Infect. Dis. 22:1900–7. http:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpubmed\u002F27767006https:\u002F\u002Fdoi.org\u002F10.3201\u002Feid2211.160519",{"doi":1748},"10.3201\u002Feid2211.160519",{"id":22,"text":1750,"url":22,"identifiers":1751},"Birgy A, Levy C, Nicolas-Chanoine M-H, Cointe A, Hobson CA, Magnan M, et al (2019) Independent host factors and bacterial genetic determinants of the emergence and dominance of Escherichia coli sequence type 131 CTX-M-27 in a Community Pediatric Cohort Study. Antimicrob. Agents Chemother. 63. https:\u002F\u002Fdoi.org\u002F10.1128\u002FAAC.00382-19",{"doi":1752},"10.1128\u002FAAC.00382-19",{"id":22,"text":1754,"url":22,"identifiers":1755},"Zong Z (2013) Complete sequence of pJIE186–2, a plasmid carrying multiple virulence factors from a sequence type 131 Escherichia coli O25 strain. Antimicrob. Agents Chemother. 57:597–600. https:\u002F\u002Faac.asm.org\u002Fcontent\u002F57\u002F1\u002F597https:\u002F\u002Fdoi.org\u002F10.1128\u002FAAC.01081-12",{"doi":1756},"10.1128\u002FAAC.01081-12",{"id":22,"text":1758,"url":22,"identifiers":1759},"Marcusson LL, Frimodt-Moller N, Hughes D (2009) Interplay in the selection of fluoroquinolone resistance and bacterial fitness. PLoS Pathog 5:e1000541. https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.ppat.1000541;10.1371\u002Fjournal.ppat.1000541",{"doi":1760},"10.1371\u002Fjournal.ppat.1000541;10.1371\u002Fjournal.ppat.1000541",{"id":22,"text":1762,"url":22,"identifiers":1763},"Machuca J, Briales A, Labrador G, Diaz-de-Alba P, Lopez-Rojas R, Docobo-Perez F, et al (2014) Interplay between plasmid-mediated and chromosomal-mediated fluoroquinolone resistance and bacterial fitness in Escherichia coli. J Antimicrob Chemother. dku308 [pii]",{"doi":1764},"10.1093\u002Fjac\u002Fdku308",{"id":22,"text":1766,"url":22,"identifiers":1767},"Mathers AJ, Peirano G, Pitout JDD (2015) The role of epidemic resistance plasmids and international high-risk clones in the spread of multidrug-resistant Enterobacteriaceae. Clin. Microbiol. Rev. 28:565–91. http:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpubmed\u002F25926236https:\u002F\u002Fdoi.org\u002F10.1128\u002FCMR.00116-14",{"doi":1768},"10.1128\u002FCMR.00116-14",{"id":22,"text":1770,"url":22,"identifiers":1771},"Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing: thirty informational supplement M100-S30. CLSI, Wayne, PA, USA, 2020",{},{"id":22,"text":1773,"url":22,"identifiers":1774},"Lopez-Cerero L, Navarro MD, Bellido M, Martin-Pena A, Vinas L, Cisneros JM, et al (2014) Escherichia coli belonging to the worldwide emerging epidemic clonal group O25b\u002FST131: risk factors and clinical implications. J. Antimicrob. Chemother. 1;69:809–14. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjac\u002Fdkt405",{"doi":1775},"10.1093\u002Fjac\u002Fdkt405",{"id":22,"text":1777,"url":22,"identifiers":1778},"Posfai G, Kolisnychenko V, Bereczki Z, Blattner FR (1999) Markerless gene replacement in Escherichia coli stimulated by a double-strand break in the chromosome. Nucleic Acids Res 15(27):4409–4415",{"doi":1779},"10.1093\u002Fnar\u002F27.22.4409",{"id":22,"text":1781,"url":22,"identifiers":1782},"Aziz RK, Bartels D, Best AA, DeJongh M, Disz T, Edwards RA, et al (2008) The RAST server: rapid annotations using subsystems technology. BMC Genomics 8;9:75. http:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpubmed\u002F18261238https:\u002F\u002Fdoi.org\u002F10.1186\u002F1471-2164-9-75",{"doi":1783},"10.1186\u002F1471-2164-9-75",{"id":22,"text":1785,"url":22,"identifiers":1786},"EUCAST. Clinical breakpoints and epidemiological cut-off values. 2020. Accessed 2020 http:\u002F\u002Fwww.eucast.org\u002Fclinical_breakpoints\u002F",{},{"id":22,"text":1788,"url":22,"identifiers":1789},"Briales A, Rodríguez-Martínez JM, Velasco C, Díaz De Alba P, Domínguez-Herrera J, Pachón J et al (2011) In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. Antimicrob Agents Chemother 55:1266–1269. https:\u002F\u002Fdoi.org\u002F10.1128\u002FAAC.00927-10",{"doi":1790},"10.1128\u002FAAC.00927-10",{"id":22,"text":1792,"url":22,"identifiers":1793},"Briales A, Rodríguez-Martínez JM, Velasco C, De Alba PD, Rodríguez-Baño J, Martínez-Martínez L, et al (2012) Prevalence of plasmid-mediated quinolone resistance determinants qnr and aac(6′)-Ib-cr in Escherichia coli and Klebsiella pneumoniae producing extended-spectrum β-lactamases in Spain. Int J Antimicrob Agents 39. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijantimicag.2011.12.009",{"doi":1794},"10.1016\u002Fj.ijantimicag.2011.12.009",{"id":22,"text":1796,"url":22,"identifiers":1797},"Machuca J, Briales A, Diaz-de-Alba P, Martinez-Martinez L, Pascual A, Rodriguez-Martinez J-M (2015) Effect of the efflux pump QepA2 combined with chromosomally mediated mechanisms on quinolone resistance and bacterial fitness in Escherichia coli. J. Antimicrob. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjac\u002Fdkv144",{"doi":1798},"10.1093\u002Fjac\u002Fdkv144",{"id":22,"text":1800,"url":22,"identifiers":1801},"Rodríguez-Martínez JM, Briales A, Velasco C, de Alba PD, Martínez-Martínez L, Pascual A (2011) Discrepancies in fluoroquinolone clinical categories between the European Committee on Antimicrobial Susceptibility Testing (EUCAST) and CLSI for Escherichia coli harbouring qnr genes and mutations in gyrA and parC. J Antimicrob Chemother 66. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjac\u002Fdkr117",{"doi":1802},"10.1093\u002Fjac\u002Fdkr117",{"id":22,"text":1804,"url":22,"identifiers":1805},"Ni S, Li B, Tang K, Yao J, Wood TK, Wang P, et al (2021) Conjugative plasmid-encoded toxin-antitoxin system PrpT\u002FPrpA directly controls plasmid copy number. Proc. Natl. Acad. Sci. U. S. A. 118. http:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpubmed\u002F33483419https:\u002F\u002Fdoi.org\u002F10.1073\u002Fpnas.2011577118",{"doi":1806},"10.1073\u002Fpnas.2011577118",{"id":22,"text":1808,"url":22,"identifiers":1809},"Muthuramalingam M, White JC, Murphy T, Ames JR, Bourne CR (2019) The toxin from a ParDE toxin-antitoxin system found in Pseudomonas aeruginosa offers protection to cells challenged with anti-gyrase antibiotics. Mol. Microbiol. 111:441–54. http:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpubmed\u002F30427086https:\u002F\u002Fdoi.org\u002F10.1111\u002Fmmi.14165",{"doi":1810},"10.1111\u002Fmmi.14165",{"id":22,"text":1812,"url":22,"identifiers":1813},"Machuca J, Agüero J, Miró E, Conejo MDC, Oteo J, Bou G, et al (2017) Prevalence of quinolone resistance mechanisms in Enterobacteriaceae producing acquired AmpC β-lactamases and\u002For carbapenemases in Spain. Enferm. Infecc. Microbiol. Clin. 35:487–92. http:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpubmed\u002F27345951https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.eimc.2016.05.006",{"doi":1814},"10.1016\u002Fj.eimc.2016.05.006",{"id":1816,"createTime":1817,"updateTime":1818,"relativeEntities":1819,"slug":1820,"properties":1821,"entityType":165,"verifyStatus":166,"verifyTime":1832,"verifyNote":168,"languages":22,"translateLanguages":22,"viewCount":23,"primaryUrl":1833,"fullTextUrl":22,"authors":1834,"publicationType":218,"publisherRelationship":1852,"citationCount":23,"citationInfo":1908,"publishDate":1911,"publishYear":1909,"citationAnalyzeStatus":1912,"lastCitationAnalyze":1818,"indexDatabases":1913,"openAccess":22,"references":22,"isForceReanalyzing":278},"2556c03d-878a-420a-814f-b76debe33d6c","2024-02-12T02:57:19.684+00:00","2026-08-24T14:23:00.743+00:00",[],"The-globalization-of-intestinal-microbiota",{"abstract":1822,"title":1824,"gsPaper":1826,"references":1828,"doi":1830},{"EN":1823},"Many microorganisms reside in human mucosa, specifically in the gut. There are many sources of the microorganisms that colonize our gut, and these sources are mainly environmental. Indeed, food is a major source of bacteria and viruses. Food also modifies the equilibrium of microorganisms in our gut, with vegetables favoring a wider diversity. The increasing role of industrial food in our alimentation is generating a globalization of our gut microbiota that may influence our health and aid the diffusion of clonal bacteria.",{"EN":1825},"The globalization of intestinal microbiota",{"VOID":1827},"[\"16830350774795171063\"]",{"VOID":1829},"Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, Nielsen T, Pons N, Levenez F, Yamada T, Mende DR, Li J, Xu J, Li S, Li D, Cao J, Wang B, Liang H, Zheng H, Xie Y, Tap J, Lepage P, Bertalan M, Batto JM, Hansen T, Le Paslier D, Linneberg A, Nielsen HB, Pelletier E, Renault P, Sicheritz-Ponten T, Turner K, Zhu H, Yu C, Li S, Jian M, Zhou Y, Li Y, Zhang X, Li S, Qin N, Yang H, Wang J, Brunak S, Doré J, Guarner F, Kristiansen K, Pedersen O, Parkhill J, Weissenbach J, Bork P, Ehrlich SD, Wang J (2010) A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464:59–65\nZhang T, Breitbart M, Lee WH, Run JQ, Wei CL, Soh SW, Hibberd ML, Liu ET, Rohwer F, Ruan Y (2006) RNA viral community in human feces: prevalence of plant pathogenic viruses. PLoS Biol 4:e3\nPalmer C, Bik EM, Digiulio DB, Relman DA, Brown PO (2007) Development of the human infant intestinal microbiota. PLoS Biol 5:e177\nLey RE (2010) Obesity and the human microbiome. Curr Opin Gastroenterol 26:5–11\nRaoult D (2008) Obesity pandemics and the modification of digestive bacterial flora. Eur J Clin Microbiol Infect Dis 27:631–634\nVijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, Srinivasan S, Sitaraman SV, Knight R, Ley RE, Gewirtz AT (2010) Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 328:228–231\nArmougom F, Henry M, Vialettes B, Raccah D, Raoult D (2009) Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and Methanogens in anorexic patients. PLoS ONE 4:e7125\nLarsen N, Vogensen FK, van den Berg FW, Nielsen DS, Andreasen AS, Pedersen BK, Al-Soud WA, Sørensen SJ, Hansen LH, Jakobsen M (2010) Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS ONE 5:e9085\nRaoult D (2008) Human microbiome: take-home lesson on growth promoters? Nature 454:690–691\nRaoult D (2009) Probiotics and obesity: a link? Nat Rev Microbiol 7:616\nThuny F, Richet H, Casalta JP, Angelakis E, Habib G, Raoult D (2010) Vancomycin treatment of infective endocarditis is linked with recently acquired obesity. PLoS ONE 5:e9074\nVincent C, Boerlin P, Daignault D, Dozois CM, Dutil L, Galanakis C, Reid-Smith RJ, Tellier PP, Tellis PA, Ziebell K, Manges AR (2010) Food reservoir for Escherichia coli causing urinary tract infections. Emerg Infect Dis 16:88–95\nColson P, Borentain P, Queyriaux B, Kaba M, Moal V, Gallian P, Heyries L, Raoult D, Gerolami R (2010) Pig liver sausage as a source of hepatitis E virus transmission to humans. J Infect Dis (in press)\nColson P, Richet H, Desnues C, Balique F, Moal V, Grob JJ, Berbis P, Lecoq H, Harlé JR, Berland Y, Raoult D (2010) Pepper mild mottle virus, a plant virus associated with specific immune responses, fever, abdominal pains, and pruritus in humans. PLoS ONE 5:e10041",{"VOID":1831},"10.1007\u002Fs10096-010-0977-0","2024-06-25T15:58:18.925+00:00","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs10096-010-0977-0",[1835],{"id":1836,"sortIndex":23,"researcher":22,"roles":1837,"affiliations":1838,"properties":1847,"displayName":1849,"givenName":22,"familyName":22},"b012d04c-4ec0-4745-9674-16bca0969e28",[176],[1839],{"id":1840,"sortIndex":23,"affiliation":1841,"properties":22},"933034ac-6d9a-40fe-b078-f1337a165e87",{"id":1840,"createTime":22,"updateTime":22,"relativeEntities":1842,"slug":22,"properties":1843,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1846,"statistic":22},[],{"title":1844},{"VI":1845},"Unité des Rickettsies, UMR CNRS 6236-IRD 198, Université de la Méditerranée, Faculté de Médecine, Marseille, France",[],{"title":1848,"gsAuthor":1850},{"VI":1849},"D. Raoult",{"VOID":1851},"[\"n8EF_6kAAAAJ\"]",{"url":1833,"publisher":1853,"properties":1903},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1854,"slug":10,"properties":1855,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":1859,"manageAffiliations":1872,"indexDatabases":1883,"url":22,"thumbnailPath":22,"statistic":1898,"gsStatistic":22,"type":144,"analyzePriority":22},[],{"issn":1856,"title":1857,"eissn":1858},{"VOID":15},{"EN":17},{"VOID":13},[1860,1864,1868],{"id":26,"createTime":22,"updateTime":22,"relativeEntities":1861,"label":1862,"description":1863,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":29},{},{"id":32,"createTime":22,"updateTime":22,"relativeEntities":1865,"label":1866,"description":1867,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":35},{},{"id":38,"createTime":22,"updateTime":22,"relativeEntities":1869,"label":1870,"description":1871,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":41},{},[1873,1878],{"id":45,"createTime":22,"updateTime":22,"relativeEntities":1874,"slug":22,"properties":1875,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1877,"statistic":22},[],{"title":1876},{"EN":49},[51],{"id":53,"createTime":22,"updateTime":22,"relativeEntities":1879,"slug":22,"properties":1880,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1882,"statistic":22},[],{"title":1881},{"EN":57},[],[1884,1891],{"id":61,"indexDatabase":1885,"url":72,"indexYears":73,"academicFieldIds":1890,"indexDatabaseRanking":78},{"id":63,"createTime":22,"updateTime":22,"relativeEntities":1886,"label":1887,"description":1888,"key":69,"publicationTags":1889,"standard":22},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75,76,77],{"id":80,"indexDatabase":1892,"url":93,"indexYears":22,"academicFieldIds":1897,"indexDatabaseRanking":22},{"id":82,"createTime":22,"updateTime":22,"relativeEntities":1893,"label":1894,"description":1895,"key":89,"publicationTags":1896,"standard":22},[],{"EN":85,"VI":85},{"EN":87,"VI":88},[91,92],[95,96],{"impactFactor":23,"impactFactorByYear":1899,"i10Index":23,"i10IndexLast5Year":23,"totalPublication":100,"totalPublicationByYear":1900,"totalCitation":136,"totalCitationByYear":1901,"totalCitationPerPublication":23,"totalCitationPerPublicationByYear":1902,"hindexLast5Year":138,"hindex":138},{"1989":99,"2014":23,"2021":23},{"1982":102,"1983":103,"1984":104,"1985":105,"1986":106,"1987":107,"1988":108,"1989":107,"1990":109,"1991":110,"1992":111,"1993":112,"1994":113,"1995":114,"1996":111,"1997":115,"1998":111,"1999":115,"2000":116,"2001":117,"2002":118,"2003":119,"2004":120,"2005":121,"2006":122,"2007":123,"2008":124,"2009":118,"2010":125,"2011":126,"2012":127,"2013":128,"2014":129,"2015":130,"2016":131,"2017":130,"2018":132,"2019":127,"2020":133,"2021":112,"2022":134,"2023":135,"2024":102},{"1987":138,"2012":139,"2019":140},{"1987":142,"2012":143,"2019":142},{"pages":1904,"volume":1906},{"VOID":1905},"1049-1050",{"VOID":1907},"29",{"total":23,"publishYear":1909,"statisticByYear":1910},2010,{},"2010-06-13","ERROR_IN_ANALYZE_CITATION",[91,78],{"id":1915,"createTime":1916,"updateTime":1917,"relativeEntities":1918,"slug":1919,"properties":1920,"entityType":165,"verifyStatus":166,"verifyTime":1929,"verifyNote":168,"languages":22,"translateLanguages":22,"viewCount":23,"primaryUrl":1930,"fullTextUrl":22,"authors":1931,"publicationType":218,"publisherRelationship":1973,"citationCount":22,"citationInfo":22,"publishDate":2029,"publishYear":2030,"citationAnalyzeStatus":2031,"lastCitationAnalyze":2032,"indexDatabases":2033,"openAccess":22,"references":22,"isForceReanalyzing":278},"526c7d80-7e55-402b-8170-f0759a1af56c","2024-01-03T04:50:36.385+00:00","2026-08-19T16:21:42.868+00:00",[],"In-vitro-blood-culture-bottle-inoculation-of-whole-blood-with-clinically-relevant-antibiotic-concentrations-a-word-of-caution",{"title":1921,"gsPaper":1923,"references":1925,"doi":1927},{"EN":1922},"In vitro blood culture bottle inoculation of whole blood with clinically relevant antibiotic concentrations: a word of caution",{"VOID":1924},"[]",{"VOID":1926},"Lovern D, Katzin B, Johnson K, Broadwell D, Miller E, Gates A, Deol P, Doing K, van Belkum A, Marshall C, Mathias E, Dunne WM Jr (2016) Antimicrobial binding and growth kinetics in BacT\u002FALERT® FA Plus and BACTEC® Aerobic\u002FF Plus blood culture media. Eur J Clin Microbiol Infect Dis 35:2033–2036. doi:10.1007\u002Fs10096-016-2759-9\nGoto M, Al-Hasan MN (2013) Overall burden of bloodstream infection and nosocomial bloodstream infection in North America and Europe. Clin Microbiol Infect 19:501–509\nLaupland KB (2013) Incidence of bloodstream infection: a review of population-based studies. Clin Microbiol Infect 19:492–500\nLaupland KB, Church DL (2014) Population-based epidemiology and microbiology of community-onset bloodstream infections. Clin Microbiol Rev 27:647–664\nSøgaard M, Lyytikäinen O, Laupland KB, Schønheyder HC (2013) Monitoring the epidemiology of bloodstream infections: aims, methods and importance. Expert Rev Anti Infect Ther 11:1281–1290\nTumbarello M, Sanguinetti M, Montuori E, Trecarichi EM, Posteraro B, Fiori B, Citton R, D’Inzeo T, Fadda G, Cauda R, Spanu T (2007) Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. Antimicrob Agents Chemother 51:1987–1994\nBarenfanger J, Graham DR, Kolluri L, Sangwan G, Lawhorn J, Drake CA, Verhulst SJ, Peterson R, Moja LB, Ertmoed MM, Moja AB, Shevlin DW, Vautrain R, Callahan CD (2008) Decreased mortality associated with prompt gram staining of blood cultures. Am J Clin Pathol 130:870–876\nFunk DJ, Kumar A (2011) Antimicrobial therapy for life-threatening infections: speed is life. Crit Care Clin 27:53–76\nDubourg G, Raoult D (2016) Emerging methodologies for pathogen identification in positive blood culture testing. Expert Rev Mol Diagn 16:97–111\nSpaargaren J, van Boven CP, Voorn GP (1998) Effectiveness of resins in neutralizing antibiotic activities in bactec plus Aerobic\u002FF culture medium. J Clin Microbiol 36:3731–3733\nChern IF, Steer JA, Wilson AP (1999) Effect of teicoplanin on isolation of Staphylococcus aureus from blood culture media. J Antimicrob Chemother 43:589–591\nViganò EF, Vasconi E, Agrappi C, Clerici P, Melloni P (2004) Use of simulated blood cultures for antibiotic effect on time to detection of the two blood culture systems BacT\u002FALERT and BACTEC 9240. New Microbiol 27:235–248\nFlayhart D, Borek AP, Wakefield T, Dick J, Carroll KC (2007) Comparison of BACTEC PLUS blood culture media to BacT\u002FAlert FA blood culture media for detection of bacterial pathogens in samples containing therapeutic levels of antibiotics. J Clin Microbiol 45:816–821\nMiller NS, Rogan D, Orr BL, Whitney D (2011) Comparison of BD Bactec Plus blood culture media to VersaTREK Redox blood culture media for detection of bacterial pathogens in simulated adult blood cultures containing therapeutic concentrations of antibiotics. J Clin Microbiol 49:1624–1627. doi:10.1128\u002FJCM.01958-10\nMitteregger D, Barousch W, Nehr M, Kundi M, Zeitlinger M, Makristathis A, Hirschl AM (2013) Neutralization of antimicrobial substances in new BacT\u002FAlert FA and FN Plus blood culture bottles. J Clin Microbiol 51:1534–1540. doi:10.1128\u002FJCM.00103-13\nSutherland CA, Nicolau DP (2016) Development of an HPLC method for the determination of ceftolozane\u002Ftazobactam in biological and aqueous matrixes. J Chromatogr Sci 54:1037–1040. doi:10.1093\u002Fchromsci\u002Fbmw047\nMerck & Co. (2015) Zerbaxa®. https:\u002F\u002Fwww.merck.com\u002Fproduct\u002Fusa\u002Fpi_circulars\u002Fz\u002Fzerbaxa\u002Fzerbaxa_pi.pdf. Accessed 19 Jul 2016",{"VOID":1928},"10.1007\u002Fs10096-016-2874-7","2024-09-05T06:35:03.220+00:00","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs10096-016-2874-7",[1932,1947,1960],{"id":1933,"sortIndex":23,"researcher":22,"roles":1934,"affiliations":1935,"properties":1944,"displayName":1946,"givenName":22,"familyName":22},"a0dcf60f-636b-41a8-bfbd-94a0f6478975",[176],[1936],{"id":1937,"sortIndex":23,"affiliation":1938,"properties":22},"89b422b7-a679-4fba-a7e2-b27b5a3e0feb",{"id":1937,"createTime":22,"updateTime":22,"relativeEntities":1939,"slug":22,"properties":1940,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1943,"statistic":22},[],{"title":1941},{"VI":1942},"Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, USA",[],{"title":1945},{"VI":1946},"M. Grupper",{"id":1948,"sortIndex":191,"researcher":22,"roles":1949,"affiliations":1950,"properties":1957,"displayName":1959,"givenName":22,"familyName":22},"7f78ca02-1409-4900-b5db-d02863973b8b",[176],[1951],{"id":1937,"sortIndex":23,"affiliation":1952,"properties":22},{"id":1937,"createTime":22,"updateTime":22,"relativeEntities":1953,"slug":22,"properties":1954,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1956,"statistic":22},[],{"title":1955},{"VI":1942},[],{"title":1958},{"VI":1959},"J. L. Kuti",{"id":1961,"sortIndex":138,"researcher":22,"roles":1962,"affiliations":1963,"properties":1970,"displayName":1972,"givenName":22,"familyName":22},"ea7075aa-81c8-42a7-a983-1ee321d605ed",[176],[1964],{"id":1937,"sortIndex":23,"affiliation":1965,"properties":22},{"id":1937,"createTime":22,"updateTime":22,"relativeEntities":1966,"slug":22,"properties":1967,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1969,"statistic":22},[],{"title":1968},{"VI":1942},[],{"title":1971},{"VI":1972},"D. P. Nicolau",{"url":1930,"publisher":1974,"properties":2024},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1975,"slug":10,"properties":1976,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":1980,"manageAffiliations":1993,"indexDatabases":2004,"url":22,"thumbnailPath":22,"statistic":2019,"gsStatistic":22,"type":144,"analyzePriority":22},[],{"issn":1977,"title":1978,"eissn":1979},{"VOID":15},{"EN":17},{"VOID":13},[1981,1985,1989],{"id":26,"createTime":22,"updateTime":22,"relativeEntities":1982,"label":1983,"description":1984,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":29},{},{"id":32,"createTime":22,"updateTime":22,"relativeEntities":1986,"label":1987,"description":1988,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":35},{},{"id":38,"createTime":22,"updateTime":22,"relativeEntities":1990,"label":1991,"description":1992,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":41},{},[1994,1999],{"id":45,"createTime":22,"updateTime":22,"relativeEntities":1995,"slug":22,"properties":1996,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1998,"statistic":22},[],{"title":1997},{"EN":49},[51],{"id":53,"createTime":22,"updateTime":22,"relativeEntities":2000,"slug":22,"properties":2001,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":2003,"statistic":22},[],{"title":2002},{"EN":57},[],[2005,2012],{"id":61,"indexDatabase":2006,"url":72,"indexYears":73,"academicFieldIds":2011,"indexDatabaseRanking":78},{"id":63,"createTime":22,"updateTime":22,"relativeEntities":2007,"label":2008,"description":2009,"key":69,"publicationTags":2010,"standard":22},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75,76,77],{"id":80,"indexDatabase":2013,"url":93,"indexYears":22,"academicFieldIds":2018,"indexDatabaseRanking":22},{"id":82,"createTime":22,"updateTime":22,"relativeEntities":2014,"label":2015,"description":2016,"key":89,"publicationTags":2017,"standard":22},[],{"EN":85,"VI":85},{"EN":87,"VI":88},[91,92],[95,96],{"impactFactor":23,"impactFactorByYear":2020,"i10Index":23,"i10IndexLast5Year":23,"totalPublication":100,"totalPublicationByYear":2021,"totalCitation":136,"totalCitationByYear":2022,"totalCitationPerPublication":23,"totalCitationPerPublicationByYear":2023,"hindexLast5Year":138,"hindex":138},{"1989":99,"2014":23,"2021":23},{"1982":102,"1983":103,"1984":104,"1985":105,"1986":106,"1987":107,"1988":108,"1989":107,"1990":109,"1991":110,"1992":111,"1993":112,"1994":113,"1995":114,"1996":111,"1997":115,"1998":111,"1999":115,"2000":116,"2001":117,"2002":118,"2003":119,"2004":120,"2005":121,"2006":122,"2007":123,"2008":124,"2009":118,"2010":125,"2011":126,"2012":127,"2013":128,"2014":129,"2015":130,"2016":131,"2017":130,"2018":132,"2019":127,"2020":133,"2021":112,"2022":134,"2023":135,"2024":102},{"1987":138,"2012":139,"2019":140},{"1987":142,"2012":143,"2019":142},{"pages":2025,"volume":2027},{"VOID":2026},"917-919",{"VOID":2028},"36","2016-12-28",2016,"ERROR_IN_GET_PLATFORM_ID","2026-08-19T16:21:42.867+00:00",[91,78]]