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Genet., 18, 69, 10.1038\u002Fng0198-69\nBusch, 2007, Apoe-epsilon4 is associated with reduced memory in long-standing intractable temporal lobe epilepsy, Neurology, 68, 409, 10.1212\u002F01.wnl.0000253021.60887.db\nCavalleri, 2005, Failure to replicate previously reported genetic associations with sporadic temporal lobe epilepsy: where to from here?, Brain, 128, 1832, 10.1093\u002Fbrain\u002Fawh524\nChapin, 2008, Apoe epsilon4 is associated with postictal confusion in patients with medically refractory temporal lobe epilepsy, Epilepsy Res., 81, 220, 10.1016\u002Fj.eplepsyres.2008.05.003\nChapman, 1996, A simple and efficient method for apolipoprotein e genotype determination, Neurology, 46, 1484, 10.1212\u002FWNL.46.5.1484-a\nDiaz-Arrastia, 2003, Increased risk of late posttraumatic seizures associated with inheritance of apoe epsilon4 allele, Arch. Neurol., 60, 818, 10.1001\u002Farchneur.60.6.818\nEngel, 1993, Outcome with respect to epileptic seizures, 609\nGallek, 2009, Apoe genotype and functional outcome following aneurysmal subarachnoid hemorrhage, Biol. Res. Nurs., 10, 205, 10.1177\u002F1099800408323221\nGambardella, 1999, Apolipoprotein e polymorphisms and the risk of nonlesional temporal lobe epilepsy, Epilepsia, 40, 1804, 10.1111\u002Fj.1528-1157.1999.tb01602.x\nGambardella, 2005, Apoe epsilon4 allele and disease duration affect verbal learning in mild temporal lobe epilepsy, Epilepsia, 46, 110, 10.1111\u002Fj.0013-9580.2005.15804.x\nGee, 2005, Astrocytes: regulation of brain homeostasis via apolipoprotein e, Int. J. Biochem. Cell Biol., 37, 1145, 10.1016\u002Fj.biocel.2004.10.004\nGouras, 1997, Increased apolipoprotein e epsilon 4 in epilepsy with senile plaques, Ann. Neurol., 41, 402, 10.1002\u002Fana.410410317\nHan, 2009, Clinical, cognitive, and genetic predictors of change in job status following traumatic brain injury in a military population, J. Head Trauma Rehabil., 24, 57, 10.1097\u002FHTR.0b013e3181957055\nHauser, 1998, Incidence and prevalence, 47\nHoltzman, 2000, Apolipoprotein e facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model, Ann. Neurol., 47, 739, 10.1002\u002F1531-8249(200006)47:6\u003C739::AID-ANA6>3.0.CO;2-8\nHorsburgh, 2000, The role of apolipoprotein e in Alzheimer's disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models, Neurobiol. Aging, 21, 245, 10.1016\u002FS0197-4580(00)00097-X\nHoulden, 2006, Apolipoprotein e4 and traumatic brain injury, J. Neurol. Neurosurg. Psychiatry, 77, 1106, 10.1136\u002Fjnnp.2006.095513\nKale, 1997, Bringing epilepsy out of the shadows, BMJ, 315, 2, 10.1136\u002Fbmj.315.7099.2\nKauffman, 2009, Apoe varepsilon4 is not associated with postictal confusion in patients with mesial temporal lobe epilepsy with hippocampal sclerosis, Epilepsy Res, 10.1016\u002Fj.eplepsyres.2009.03.012\nKumar, 2006, Apolipoprotein e in temporal lobe epilepsy: a case–control study, Dis. Mark., 22, 335, 10.1155\u002F2006\u002F951632\nLevi, 2003, Apoe4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory, Neurobiol. Dis., 13, 273, 10.1016\u002FS0969-9961(03)00045-7\nLiang, 2009, Apolipoprotein e polymorphism in normal Han Chinese population: frequency and effect on lipid parameters, Mol. Biol. Rep., 36, 1251, 10.1007\u002Fs11033-008-9305-5\nLomnitski, 1999, Antioxidant mechanisms in apolipoprotein e deficient mice prior to and following closed head injury, Biochim. Biophys. Acta, 1453, 359, 10.1016\u002FS0925-4439(99)00010-1\nLopez, 2008, Increased intraneuronal resting [ca2+] in adult Alzheimer's disease mice, J. Neurochem., 105, 262, 10.1111\u002Fj.1471-4159.2007.05135.x\nLynch, 2008, Apolipoprotein e promoter polymorphisms (−491a\u002Ft and −427t\u002Fc) and Alzheimer's disease: no evidence of association in the Irish population, Ir. J. Med. Sci., 177, 29, 10.1007\u002Fs11845-007-0098-7\nMackenzie, 1994, Senile plaques in temporal lobe epilepsy, Acta Neuropathol., 87, 504, 10.1007\u002FBF00294177\nMo, 1998, The apolipoprotein e epsilon4 allele and outcome in cerebrovascular disease, Stroke, 29, 1882, 10.1161\u002F01.STR.29.9.1882\nPalop, 2009, Epilepsy and cognitive impairments in Alzheimer disease, Arch. Neurol., 66, 435, 10.1001\u002Farchneurol.2009.15\nPoirier, 1994, Apolipoprotein e in animal models of cns injury and in Alzheimer's disease, Trends Neurosci., 17, 525, 10.1016\u002F0166-2236(94)90156-2\nPolvikoski, 1995, Apolipoprotein e, dementia, and cortical deposition of beta-amyloid protein, N. Engl. J. Med., 333, 1242, 10.1056\u002FNEJM199511093331902\nSabo, 2000, Susceptibility of transgenic mice expressing human apolipoprotein e to closed head injury: the allele e3 is neuroprotective whereas e4 increases fatalities, Neuroscience, 101, 879, 10.1016\u002FS0306-4522(00)00438-3\nSheng, 1999, Apolipoprotein e deficiency worsens outcome from global cerebral ischemia in the mouse, Stroke, 30, 1118, 10.1161\u002F01.STR.30.5.1118\nSheng, 1994, Increased neuronal beta-amyloid precursor protein expression in human temporal lobe epilepsy: association with interleukin-1 alpha immunoreactivity, J. 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Mathematical studies of diffusion kinetics, J. Pharmacol. Meth., 22, 157, 10.1016\u002F0160-5402(89)90012-0\nBearden, 1980, Antagonism of gamma-hydroxybutyric acid-induced frequency shifts in the cortical EEG of rats by dipropylacetate, Electroenceph. Clin. Neurophysiol., 49, 181, 10.1016\u002F0013-4694(80)90365-X\nBenavides, 1982, High affinity binding site for gamma-hydroxybutyric acid in rat brain, Life Sci., 30, 953, 10.1016\u002F0024-3205(82)90624-5\nBertharion, 1962, Etude stéréotaxique des potentiels évoqués sous semi-aldéhyde succinique, Agressologie, 3, 489\nBessman, 1963, Gamma hydroxybutyrate, a normal brain metabolite, Nature, 200, 1207, 10.1038\u002F2001207a0\nBrankačk, 1991, Epileptic spikes and seizures but not high voltage spindles are induced by local frontal cortical application of gamma-hydroxybutyrate, 86\nBuzsáki, 1988, Electrical activity in the neocortex of freely moving young and aged rats, Neuroscience, 26, 735, 10.1016\u002F0306-4522(88)90095-4\nBuzsáki, 1990, Petit mal epilepsy and parkinsonian tremor: hypothesis of a common pacemaker, Neuroscience, 36, 1, 10.1016\u002F0306-4522(90)90345-5\nBuzsáki, 1990, Spike-and-wave neocortical patterns in rats: Genetic and aminergic control, Neuroscience, 38, 323, 10.1016\u002F0306-4522(90)90031-X\n1988, 21\nDepaulis, 1988, Effects of gamma-hydroxybutyrate and gamma-butyrolactone derivatives on spontaneous generalized non-convulsive seizures in the rat, Neuropharmacology, 27, 683, 10.1016\u002F0028-3908(88)90076-7\nDingledine, 1979, Penicillin blocks hippocampal IPSPs, unmasking prolonged EPSPs, Brain Res., 168, 205, 10.1016\u002F0006-8993(79)90141-0\nEnna, 1975, Properties of gamma-aminobutyric acid (GABA) receptor binding in rat brain synaptic membrane fractions, Brain Res., 100, 81, 10.1016\u002F0006-8993(75)90243-7\nEnna, 1979, Biochemical pharmacology of GABAergic agonists, Life Sci., 24, 1717, 10.1016\u002F0024-3205(79)90060-2\nGloor, 1979, Generalized epilepsy with spike-and-wave discharge: a reinterpretation of its electrographic and clinical manifestations, Epilepsia, 20, 571, 10.1111\u002Fj.1528-1157.1979.tb04840.x\nGloor, 1977, Pathophysiology of generalized penicillin epilepsy in the cat: The role of cortical and subcortical structures. II. Topical application of penicillin to the cerebral cortex and to subcortical structures, Electroenceph. Clin. Neurophysiol., 43, 79, 10.1016\u002F0013-4694(77)90198-5\nGodschalk, 1976, Antagonism of gamma-hydroxybutyrate-induced hypersynchronization in the ECoG of the rat by anti-petit mal drugs, Neurosci. Lett., 3, 145, 10.1016\u002F0304-3940(76)90084-7\nGodschalk, 1977, Slow wave sleep and a state resembling absence epilepsy induced in the rat by gamma-hydroxybutyrate, Eur. J. Pharmacol., 44, 105, 10.1016\u002F0014-2999(77)90096-6\nGuberman, 1975, Response of generalized penicillin epilepsy in the cat to ethosuximide and diphenylhydantoin, Neurology (Minneap.), 25, 758, 10.1212\u002FWNL.25.8.758\nHarris, 1989, Effects of gamma-hydroxybutyrate on the membrane properties of guinea pig pars compacta neurons in the substantia nigra in vitro, Neuroscience, 31, 363, 10.1016\u002F0306-4522(89)90380-1\nHu, 1989, The effects of brainstem peribrachial stimulation on perigeniculate neurons: the blockage of spindle waves, Neuroscience, 31, 1, 10.1016\u002F0306-4522(89)90026-2\nKohler, 1969, Auslösung von Spindelaktivitet im Neokortex der Ratte durch Reizung des ventralen Thalamuskernes, Acta Biol. Med. Germ., 23, 99\nLaborit, 1973, Gamma-hydroxybutyrate, succinic semialdehyde and sleep, Prog. Neurobiol, 1, 257, 10.1016\u002F0301-0082(73)90014-2\nLahtinen, 1991, Gamma-hydroxybutyrate applied intracortically induces epileptogenic spikes and seizures and increases somatostatin release; Microdialysis combined with EEG recording, 152\nLahtinen, 1992, Somatostatin release in rat neocortex during gammahydroxybutyrate-provoked seizures: Microdialysis combined with EEG recording, Brain Res. Bull., 29, 837, 10.1016\u002F0361-9230(92)90152-N\nLindefors, 1987, Microdialysis combined with sensitive radioimmunoassay. A technique for studying in vivo release of neuropeptides, J. Pharmacol. Meth., 17, 305, 10.1016\u002F0160-5402(87)90044-1\nLiu, 1991, Intrathalamic injections of gamma-hydroxybutyric acid increase genetic absence seizures in rats, Neurosci. Lett., 125, 19, 10.1016\u002F0304-3940(91)90119-E\nMarescaux, 1984, A model of chronic spontaneous petit mal-like seizures in the rat: comparison with pentylenetetrazol-induced seizures, Epilepsia, 25, 326, 10.1111\u002Fj.1528-1157.1984.tb04196.x\nMeldrum, 1981, GABA-agonists as anti-epileptic agents, Adv. Biochem. Psychopharmacol., 26, 207\nMirsky, 1986, Petit mal epilepsy: a review and integration of recent information, J. Clin. Neurophysiol., 3, 179, 10.1097\u002F00004691-198607000-00001\nOlpe, 1979, Inhibition of nigral and neocortical cells by gamma-hydroxybutyrate: a microiontophoretic investigation, Eur. J. Pharmacol., 53, 359, 10.1016\u002F0014-2999(79)90460-6\nOsprio, 1979, Gamma-hydroxybutyric acid is not a GABA-mimetic agent in the spinal cord, Ann. Neurol., 6, 111, 10.1002\u002Fana.410060206\nQuesney, 1977, Pathophysiology of generalized penicillin epilepsy in the cat: The role of cortical and subcortical structures. I. Systemic application of penicillin, Electroenceph. Clin. Neurophysiol., 42, 640, 10.1016\u002F0013-4694(77)90281-4\nRoth, 1970, Natural occurrence of gamma-hydroxybutyrate in mammalian brain, Biochem. Pharmacol., 19, 1087, 10.1016\u002F0006-2952(70)90370-9\nSchneiderman, 1986, Low concentrations of penicillin reveal rhythmic, synchronous synaptic potentials in hippocampal slice, Brain Res., 398, 231, 10.1016\u002F0006-8993(86)91482-4\nSnead, 1976, Gamma hydroxybutyrate: Correlation of serum and cerebrospinal fluid levels with electroencephalographic and behavioral effects, Neurology (Minneap.), 26, 51, 10.1212\u002FWNL.26.1.51\nSnead, 1978, Gamma hydroxybutyrate in the monkey. I. Electroencephalographic, behavioral, and pharmacokinetic studies, Neurology (Minneap.), 28, 636, 10.1212\u002FWNL.28.7.636\nSnead, 1984, Ontogeny of gamma-hydroxybutyric acid. II. Electroencephalographic effects, Dev. Brain Res., 15, 89, 10.1016\u002F0165-3806(84)90143-3\nSnead, 1984, Gamma-hydroxybutyric acid binding sites in rat and human brain synaptosomal membranes, Biochem. Pharmacol., 33, 2587, 10.1016\u002F0006-2952(84)90629-4\nSnead, 1988, Gamma-hydroxybutyrate model of generalized absence seizures: further characterization and comparison with other absence models, Epilepsia, 29, 361, 10.1111\u002Fj.1528-1157.1988.tb03732.x\nSnead, 1990, Effect of intrathalamic gammahydroxybutyric acid in rats with and without spontaneous spike wave discharge, 31, 651\nSnead, 1992, Gamma-hydroxybutyric acids binding sites: Interaction with the GABA-benzodiazepine-picrotoxin receptor complex, Neurochem. Res., 17, 201, 10.1007\u002FBF00966800\nSteriade, 1984, The thalamus as a neuronal oscillator, Brain Res. Rev., 8, 1, 10.1016\u002F0165-0173(84)90017-1\nSteriade, 1985, Abolition of spindle oscillations in thalamic neurons disconnected from nucleus reticularis thalami, J. 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Transl. Med., 7, 10.1126\u002Fscitranslmed.aaa4050\nAllen, 2017, Dysfunctional brain networking among autonomic regulatory structures in temporal lobe epilepsy patients at high risk of sudden unexpected death in epilepsy, Front. Neurol., 8, 544, 10.3389\u002Ffneur.2017.00544\nBateman, 2008, Ictal hypoxemia in localization-related epilepsy: analysis of incidence, severity and risk factors, Brain, 131, 3239, 10.1093\u002Fbrain\u002Fawn277\nBuchanan, 2014, Serotonin neurones have anti-convulsant effects and reduce seizure-induced mortality, J. Physiol., 592, 4395, 10.1113\u002Fjphysiol.2014.277574\nDampney, 2013, Role of dorsolateral periaqueductal grey in the coordinated regulation of cardiovascular and respiratory function, Auton. Neurosci., 175, 17, 10.1016\u002Fj.autneu.2012.12.008\nDarbin, 2002, Cardiac dysrhythmia associated with the immediate postictal state after maximal electroshock in freely moving rat, Epilepsia, 43, 336, 10.1046\u002Fj.1528-1157.2002.34801.x\nDavis, 2013, Rodent models of sleep apnea, Resp. Physiol. Neurobiol., 188, 355, 10.1016\u002Fj.resp.2013.05.022\nDeckard, 1976, Developmental patterns of seizure susceptibility in inbred strains of mice, Dev. Psychobiol., 9, 17, 10.1002\u002Fdev.420090104\nDekker, 2000, Low heart rate variability in a 2-minute rhythm strip predicts risk of coronary heart disease and mortality from several causes. The ARIC study, Circulation, 102, 1239, 10.1161\u002F01.CIR.102.11.1239\nDevinsky, 2004, Effects of seizures on autonomic and cardiovascular function, Epilepsy Curr., 4, 43, 10.1111\u002Fj.1535-7597.2004.42001.x\nDevinsky, 2016, Sudden unexpected death in epilepsy: epidemiology, mechanisms, and prevention, Lancet Neurol., 15, 1075, 10.1016\u002FS1474-4422(16)30158-2\nFaingold, 2010, DBA\u002F1 mice exhibit chronic susceptibility to audiogenic seizures followed by sudden death associated with respiratory arrest, Epilepsy Behav., 17, 436, 10.1016\u002Fj.yebeh.2010.02.007\nFaingold, 2011, Differences in serotonin receptor expression in the brainstem may explain the differential ability of a serotonin agonist to block seizure-induced sudden death in DBA\u002F2 vs. DBA\u002F1 mice, Brain Res., 1418, 104, 10.1016\u002Fj.brainres.2011.08.043\nFaingold, 2011, Prevention of seizure-induced sudden death in a chronic SUDEP model by semichronic administration of a selective serotonin reuptake inhibitor, Epilepsy Behav., 22, 186, 10.1016\u002Fj.yebeh.2011.06.015\nFaingold, 2012, Brainstem networks: reticulo-cortical synchronization in generalized convulsive seizures\nFaingold, 2015, Neurotransmitters implicated in control of sudden unexpected death in epilepsy in animal models\nFaingold, 2016, Serotonergic agents act on 5-HT3 receptors in the brain to block seizure-induced respiratory arrest in the DBA\u002F1 mouse model of SUDEP, Epilepsy Behav., 64, 166, 10.1016\u002Fj.yebeh.2016.09.034\nFaull, 2015, Functional subdivision of the human periaqueductal grey in respiratory control using 7 tesla fMRI, NeuroImage, 113, 356, 10.1016\u002Fj.neuroimage.2015.02.026\nFaull, 2016, Conditioned respiratory threat in the subdivisions of the human periaqueductal gray, ELife, 5, 10.7554\u002FeLife.12047\nFranklin, 1997\nGarcia-Cairasco, 2002, A critical review on the participation of inferior colliculus in acoustic-motor and acoustic-limbic networks involved in the expression of acute and kindled audiogenic seizures, Hearing Res., 168, 208, 10.1016\u002FS0378-5955(02)00371-4\nGray, 2010, Developmental origin of preBotzinger complex respiratory neurons, J. Neurosci., 30, 14883, 10.1523\u002FJNEUROSCI.4031-10.2010\nGreen, 2010, Intra-operative deep brain stimulation of the periaqueductal grey matter modulates blood pressure and heart rate variability in humans, Neuromodulation, 13, 174, 10.1111\u002Fj.1525-1403.2010.00274.x\nGroeben, 2003, Heritable differences in respiratory drive and breathing pattern in mice during anaesthesia and emergence, Br. J. Anaesth., 91, 541, 10.1093\u002Fbja\u002Faeg222\nHayward, 2002, c-Fos expression in the midbrain periaqueductal gray after chemoreceptor and baroreceptor activation, Am. J. Physiol. Heart Circ. Physiol., 283, H1975, 10.1152\u002Fajpheart.00300.2002\nHayward, 2004, Parabrachial neurons mediate dorsal periaqueductal gray evoked respiratory responses in the rat, J. Appl. Physiol. (Bethesda, Md.: 1985), 96, 1146, 10.1152\u002Fjapplphysiol.00903.2003\nHyam, 2014, Control of the lungs via the human brain using neurosurgery, Prog. Brain Res., 209, 341, 10.1016\u002FB978-0-444-63274-6.00018-7\nIigaya, 2010, Topographical specificity of regulation of respiratory and renal sympathetic activity by the midbrain dorsolateral periaqueductal gray, Am. J. Physiol. Regul. Integr. Comp. Physiol., 299, R853, 10.1152\u002Fajpregu.00249.2010\nKalume, 2013, Sudden unexpected death in a mouse model of Dravet syndrome, J. Clin. Invest., 123, 1798, 10.1172\u002FJCI66220\nKoba, 2016, Role played by periaqueductal gray neurons in parasympathetically mediated fear bradycardia in conscious rats, Physiol. Rep., 4, 10.14814\u002Fphy2.12831\nKohnken, 2016, Lack of chronic histologic lesions supportive of sublethal spontaneous seizures in FVB\u002FN Mice, Comp. 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