[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_5b2f438b-ce6e-4c5a-92ad-10f4a0a1246b":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:5b2f438b-ce6e-4c5a-92ad-10f4a0a1246b,\"}":92},{"code":4,"data":5,"meta":24},"SUCCESS",{"id":6,"createTime":7,"updateTime":8,"relativeEntities":9,"slug":10,"properties":11,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":26,"manageAffiliations":39,"indexDatabases":54,"url":91,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},"5b2f438b-ce6e-4c5a-92ad-10f4a0a1246b","2023-05-29T11:18:32.571+00:00","2025-11-21T09:54:35.608+00:00",[],"Environmental-Toxicology-and-Chemistry",{"country":12,"eissn":14,"issn":16,"title":18,"introduce":20},{"VOID":13},"US",{"VOID":15},"07307268",{"VOID":17},"15528618",{"EN":19},"Environmental Toxicology and Chemistry",{"EN":21},"The Society of Environmental Toxicology and Chemistry (SETAC) publishes two journals: Environmental Toxicology and Chemistry (ET&C) and Integrated Environmental Assessment and Management (IEAM). Environmental Toxicology and Chemistry is dedicated to furthering scientific knowledge and disseminating information on environmental toxicology and chemistry, including the application of these sciences to risk assessment.[...] Environmental Toxicology and Chemistry is interdisciplinary in scope and integrates the fields of environmental toxicology; environmental, analytical, and molecular chemistry; ecology; physiology; biochemistry; microbiology; genetics; genomics; environmental engineering; chemical, environmental, and biological modeling; epidemiology; and earth sciences. ET&C seeks to publish papers describing original experimental or theoretical work that significantly advances understanding in the area of environmental toxicology, environmental chemistry and hazard\u002Frisk assessment. Emphasis is given to papers that enhance capabilities for the prediction, measurement, and assessment of the fate and effects of chemicals in the environment, rather than simply providing additional data. The scientific impact of papers is judged in terms of the breadth and depth of the findings and the expected influence on existing or future scientific practice. Methodological papers must make clear not only how the work differs from existing practice, but the significance of these differences to the field. Site-based research or monitoring must have regional or global implications beyond the particular site, such as evaluating processes, mechanisms, or theory under a natural environmental setting.","PUBLISHER","PENDING",null,0,[27,33],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":29,"label":30,"description":32,"parentId":24,"standard":24,"scholarHubFieldId":24},"fd62165d-2af9-4727-927d-7520b8de74ed",[],{"EN":31},"Health, Toxicology and Mutagenesis",{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":35,"label":36,"description":38,"parentId":24,"standard":24,"scholarHubFieldId":24},"ba398c11-4a62-45f4-af80-7b601f393976",[],{"EN":37},"Environmental Chemistry",{},[40,47],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":42,"slug":24,"properties":43,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":46,"statistic":24},"b89d4fd0-cd7c-45fd-97a1-ec784c5e5841",[],{"title":44},{"EN":45},"Wiley-Blackwell",[],{"id":48,"createTime":24,"updateTime":24,"relativeEntities":49,"slug":24,"properties":50,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":53,"statistic":24},"43d4a537-d044-4372-8544-ca45c3bea38f",[],{"title":51},{"EN":52},"WILEY",[],[55,73],{"id":56,"indexDatabase":57,"url":67,"indexYears":68,"academicFieldIds":69,"indexDatabaseRanking":72},"24a5aa68-334f-4960-8519-07249f2d3a1e",{"id":58,"createTime":24,"updateTime":24,"relativeEntities":59,"label":60,"description":62,"key":64,"publicationTags":65,"standard":24},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9",[],{"EN":61,"VI":61},"Scopus - Elsevier",{"EN":61,"VI":63},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[66],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F25094","1982-2025",[70,71],"95c24511-ec49-4593-81a0-ce6e3c1f9f9e","37f74bc4-acc7-45e0-bf55-b7082b6cfb92","SCOPUS__Q1",{"id":74,"indexDatabase":75,"url":87,"indexYears":24,"academicFieldIds":88,"indexDatabaseRanking":24},"b53c8e87-4ca4-48a1-9b7f-798c404b72d9",{"id":76,"createTime":24,"updateTime":24,"relativeEntities":77,"label":78,"description":80,"key":83,"publicationTags":84,"standard":24},"a4921856-b128-4d9f-8f1f-e80813d3bbd4",[],{"EN":79,"VI":79},"ISI\u002FSCIE - Science Citation Index Expanded",{"EN":81,"VI":82},"SCIE database","Cơ sở dữ liệu SCIE","scie",[85,86],"SCIE","ISI","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=0730-7268",[89,90],"1ff2b686-ac7f-4d79-91fb-d25180fb47ca","d35f7cb1-70f1-41cc-b01c-ebcc9f6a923d","https:\u002F\u002Fsetac.onlinelibrary.wiley.com\u002Fjournal\u002F15528618",{"meta":93,"data":95},{"total":94},"362",[96,285,672,955,1505,1776,2122,2412,2713,2997],{"id":97,"createTime":98,"updateTime":99,"relativeEntities":100,"slug":101,"properties":102,"entityType":117,"verifyStatus":118,"verifyTime":98,"verifyNote":119,"languages":120,"translateLanguages":24,"viewCount":25,"primaryUrl":122,"fullTextUrl":24,"authors":123,"publicationType":187,"publisherRelationship":188,"citationCount":238,"citationInfo":239,"publishDate":244,"publishYear":240,"citationAnalyzeStatus":23,"lastCitationAnalyze":245,"indexDatabases":246,"openAccess":24,"references":247,"isForceReanalyzing":284},"a07ff1e7-7167-4cea-808f-fff059e0db12","2024-10-08T23:01:14.413+00:00","2026-07-30T17:54:40.500+00:00",[],"Quantifying-the-anthropogenic-fraction-of-fatty-alcohols-in-a-terrestrial-environment",{"mag":103,"gsPaper":105,"openalex":107,"abstract":109,"title":111,"pm":113,"doi":115},{"VOID":104},"1977845369",{"VOID":106},"[\"16144218984851777916\"]",{"VOID":108},"W1977845369",{"EN":110},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Fatty alcohols are naturally produced hydrocarbons present in all living organisms. They are also used in detergent and cosmetic formulations, may be sourced from either petroleum or biological materials, and are typically disposed of down the drain. This study was conducted on the Luray catchment, Virginia, USA, where sales data indicate that approximately 2 kg of fatty alcohols from detergent enter the wastewater every day. Reconstructing fatty alcohols in the influent on the basis of sales data indicated a mix of odd and even chain compounds, with C\u003Cjats:sub>12\u003C\u002Fjats:sub> being dominant. This profile was influenced strongly by liquid laundry detergents (69%). Sediment and soil samples from the catchment were analyzed by gas chromatography–mass spectrometry and by stable isotope ratio mass spectrometry to determine the δ\u003Cjats:sup>13\u003C\u002Fjats:sup>C and δ\u003Cjats:sup>2\u003C\u002Fjats:sup>H signatures. The long‐chain components in agricultural soils and river sediments were distinguishable clearly from the algal fatty alcohols produced within the river system. The wastewater was a mixture of fecal and detergent sources of fatty alcohols in a ratio of 75:25%. The fatty alcohols in the effluent had different stable isotopic signatures and chain‐length profiles from the influent, indicating that these compounds are not the same as those that entered the treatment plant. The total quantity of fatty alcohols leaving the treatment plant through the effluent pipe was low compared with the input. Analysis of the contributions based on the stable isotopes and profiles suggests that of the fatty alcohols present in the river system downstream of the treatment plant, 84% were derived from terrestrial plant production, 15% came from in situ algal synthesis, and 1% were derived from the effluent. Environ. Toxicol. Chem. 2012;31:1209–1222. © 2012 SETAC\u003C\u002Fjats:p>",{"EN":112},"Quantifying the anthropogenic fraction of fatty alcohols in a terrestrial environment",{"VOID":114},"22513817",{"VOID":116},"10.1002\u002Fetc.1808","PUBLICATION","VERIFIED","Auto Verify",[121],"EN","https:\u002F\u002Fsetac.onlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fetc.1808",[124,145,167],{"id":125,"sortIndex":25,"researcher":24,"roles":126,"affiliations":127,"properties":136,"displayName":140,"givenName":24,"familyName":24},"5b37f686-271c-4505-b954-02f33018d35b",[],[128],{"id":129,"sortIndex":25,"affiliation":130,"properties":24},"a961b92a-a734-4954-aadd-3509b0966a92",{"id":129,"createTime":24,"updateTime":24,"relativeEntities":131,"slug":24,"properties":132,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":135,"statistic":24},[],{"title":133},{"EN":134},"Exponent UK, Harrogate, United Kingdom.",[],{"orcid":137,"title":139,"gsAuthor":141,"openalex":143},{"VOID":138},"https:\u002F\u002Forcid.org\u002F0000-0002-5198-0841",{"EN":140},"Stephen M. 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The estrogen concentrations in water and sludge samples, collected in October 2004 and April 2005, were determined by gas chromatography‐mass spectrometry and liquid chromatography‐tandem mass spectrometry. Simultaneously, the estrogenic activity was quantified using estrogen‐responsive reporter cell lines (MELN) to investigate the behavior of overall estrogenic compounds. The estrogen concentrations in the inlet ranged from 200 to 500 ng\u002FL, with the contribution of conjugated forms being higher than 50%. The major estrogens in influent were E\u003Cjats:sub>1\u003C\u002Fjats:sub> and E\u003Cjats:sub>3\u003C\u002Fjats:sub>. The estrogenic activity was between 25 and 130 ng\u002FL of E\u003Cjats:sub>2\u003C\u002Fjats:sub> equivalents (EEQs). Estrogen concentrations and estrogenicity measured in the inlet and in primary treated sewage were similar, showing a weak impact of primary treatment on hormone removal. In contrast, both estrogen concentration and estrogenicity decreased during biological treatment, with high removal efficiencies (>90%). Estrone, E\u003Cjats:sub>2\u003C\u002Fjats:sub>, and EE\u003Cjats:sub>2\u003C\u002Fjats:sub> persisted in the treated water below 10 ng\u002FL, whereas the estrogenicity was lower than 5 ng\u002FL of EEQs. Estrogen mass flux in the effluent and sludge represented less than 2 and 4%, respectively, of the inlet. Consequently, the fraction of estrogens sorbed into the sludge was very small, and biodegradation was the main vehicle for estrogen elimination. This dual approach, comparing chemical and biological analysis, allowed us to confirm that most of the estrogenic activity occurring in this STP, which receives mainly domestic sewage, resulted from sex hormones.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Các hormone steroid estrone (E\u003Cjats:sub>1\u003C\u002Fjats:sub>), 17β‐estradiol (E\u003Cjats:sub>2\u003C\u002Fjats:sub>), estriol (E\u003Cjats:sub>3\u003C\u002Fjats:sub>), 17α‐ethinylestradiol (EE\u003Cjats:sub>2\u003C\u002Fjats:sub>), và các dạng liên hợp của chúng đã được khảo sát trong một nhà máy xử lý nước thải nâng cao (STP). Nồng độ estrogen trong mẫu nước và bùn, được thu thập vào tháng 10 năm 2004 và tháng 4 năm 2005, đã được xác định bằng phương pháp sắc ký khí-spectrometric khối lượng và sắc ký lỏng-spectrometric khối lượng giai đoạn tandem. Đồng thời, hoạt tính estrogen được định lượng bằng cách sử dụng các dòng tế bào đáp ứng estrogen (MELN) để điều tra hành vi của tổng thể các hợp chất estrogen. Nồng độ estrogen tại đầu vào dao động từ 200 đến 500 ng\u002FL, với tỷ lệ các dạng liên hợp chiếm hơn 50%. Các estrogen chính trong nước thải đầu vào là E\u003Cjats:sub>1\u003C\u002Fjats:sub> và E\u003Cjats:sub>3\u003C\u002Fjats:sub>. Hoạt tính estrogen dao động trong khoảng từ 25 đến 130 ng\u002FL tương đương E\u003Cjats:sub>2\u003C\u002Fjats:sub> (EEQs). Nồng độ estrogen và hoạt tính estrogen đo được ở đầu vào và trong nước thải đã qua xử lý sơ bộ tương tự nhau, cho thấy tác động yếu của quá trình xử lý sơ bộ đối với việc loại bỏ hormone. Ngược lại, cả nồng độ estrogen và hoạt tính estrogen đều giảm trong quá trình xử lý sinh học, với hiệu suất loại bỏ cao (>90%). Estrone, E\u003Cjats:sub>2\u003C\u002Fjats:sub>, và EE\u003Cjats:sub>2\u003C\u002Fjats:sub> tồn tại trong nước đã xử lý dưới 10 ng\u002FL, trong khi hoạt tính estrogen thấp hơn 5 ng\u002FL EEQs. Lưu lượng khối lượng estrogen trong nước thải ra và bùn đại diện cho dưới 2% và 4%, tương ứng, của đầu vào. Do đó, phần của estrogen được hấp phụ vào bùn là rất nhỏ, và sự phân hủy sinh học là phương thức chính để loại bỏ estrogen. 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tắt\u003C\u002Fjats:title>\u003Cjats:p>Các mẫu nước đầu vào (chưa qua xử lý) và nước thải (đã qua xử lý) từ 18 nhà máy xử lý nước thải (WWTP) tại 14 đô thị ở Canada đã được phân tích để kiểm tra dư lượng của một số loại thuốc kê đơn và không kê đơn. Nhiều loại thuốc trung tính và axit đã được phát hiện trong nước thải, bao gồm các chất giảm đau\u002Fkháng viêm, chất điều hòa lipid và thuốc chống động kinh, carbamazepine. Dư lượng đã được chiết xuất từ nước thải bằng phương pháp chiết xuất pha rắn, sau đó hoặc là methyl hóa và phân tích các thuốc axit bằng sắc ký khí\u002Fkỹ thuật khối phổ, hoặc phân tích trực tiếp các thuốc trung tính bằng sắc ký lỏng\u002Fkỹ thuật khối phổ nối tiếp. Các thuốc giảm đau\u002Fkháng viêm như ibuprofen và naproxen, cũng như chất chuyển hóa của axit acetylsalicylic, axit salicylic, thường được phát hiện trong nước thải cuối với nồng độ μg\u002FL. Chất điều hòa lipid axit clofibric và thuốc giảm đau\u002Fkháng viêm diclofenac không được phát hiện trong bất kỳ mẫu nước thải cuối nào, điều này không nhất quán với dữ liệu từ châu Âu. Tiền chất của axit clofibric, clofibrate, không được kê đơn rộng rãi như một chất điều hòa lipid ở Canada. Tuy nhiên, các chất điều hòa lipid bezafibrate và gemfibrozil đã được phát hiện trong một số mẫu nước đầu vào và nước thải. Các thuốc hóa trị liệu ifosfamide và cyclophosphamide cùng với thuốc chống viêm phenazone không được phát hiện trong mẫu nước đầu vào hoặc nước thải, nhưng thuốc giãn mạch pentoxyfylline đã được phát hiện với nồng độ ng\u002FL trong một số nước thải cuối. Sự phổ biến của carbamazepine với nồng độ cao tới 2.3 μg\u002FL có thể được giải thích bởi việc sử dụng loại thuốc này cho các mục đích điều trị khác ngoài điều trị động kinh và khả năng chống lại việc loại bỏ trong các nhà máy xử lý nước thải. Tỷ lệ loại bỏ ibuprofen và naproxen dường như tăng cao ở các nhà máy xử lý nước thải có thời gian lưu giữ thủy lực cho nước thải lớn hơn 12 giờ.\u003C\u002Fjats:p>","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Samples of influent (untreated) and effluent (treated) from 18 sewage treatment plants (STPs) in 14 municipalities in Canada were analyzed for residues of selected prescription and nonprescription drugs. Several neutral and acidic drugs were detected in effluents, including analgesic\u002Fanti‐inflammatory agents, lipid regulators, and an antiepileptic drug, carbamazepine. Residues were extracted from effluents by solid‐phase extraction, followed by either methylation and analysis of acidic drugs by gas chromatography\u002Fmass spectrometry or direct analysis of neutral drugs by liquid chromatography\u002Ftandem mass spectrometry. Analgesic\u002Fanti‐inflammatory drugs such as ibuprofen and naproxen, as well as the metabolite of acetylsalicyclic acid, salicylic acid, were often detected in final effluents at μg\u002FL concentrations. The acidic lipid regulator, clofibric acid, and the analgesic\u002Fanti‐inflammatory drug diclofenac were not detected in any final effluent samples, which is not consistent with data from Europe. The precursor to clofibric acid, clofibrate, is not widely prescribed as a lipid regulator in Canada. However, the lipid regulators bezafibrate and gemfibrozil were detected in some samples of influent and effluent. The chemotherapy drugs ifosfamide and cyclophosphamide and the anti‐inflammatory phenazone were not detected in influent or effluent samples, but the vasodilator drug pentoxyfylline was detected at ng\u002FL concentrations in some final effluents. The widespread occurrence of carbamazepine at concentrations as high as 2.3 μg\u002FL may be explained by use of this drug for other therapeutic purposes besides treatment of epilepsy and its resistance to elimination in STPs. The rates of elimination of ibuprofen and naproxen appeared to be elevated in STPs with hydraulic retention times for sewage greater than 12 h.\u003C\u002Fjats:p>",{"EN":690,"VI":691},"Occurrence of neutral and acidic drugs in the effluents of Canadian sewage treatment plants","Sự xuất hiện của thuốc trung tính và axit trong nước thải của các nhà máy xử lý nước thải ở Canada",{"VOID":693},"14713026",{"VOID":695},"10.1897\u002F02-469","2025-01-02T12:36:54.961+00:00",[121],[308],"https:\u002F\u002Fsetac.onlinelibrary.wiley.com\u002Fdoi\u002F10.1897\u002F02-469",[701,720,735,752,769,788],{"id":702,"sortIndex":25,"researcher":24,"roles":703,"affiliations":704,"properties":713,"displayName":717,"givenName":24,"familyName":24},"db940361-c79e-4ac8-a1ea-361e62dac39e",[],[705],{"id":706,"sortIndex":25,"affiliation":707,"properties":24},"2d922445-369a-49e6-ba2a-9da3ec4bd546",{"id":706,"createTime":24,"updateTime":24,"relativeEntities":708,"slug":24,"properties":709,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":712,"statistic":24},[],{"title":710},{"EN":711},"Water Quality Centre, Trent University, Peterborough, Ontario, Canada K9J 7B8",[],{"orcid":714,"title":716,"openalex":718},{"VOID":715},"https:\u002F\u002Forcid.org\u002F0000-0002-6807-9048",{"EN":717},"Chris D. 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extensive database of acute and chronic aquatic toxicity data for 18 phthalate esters was reviewed and summarized for freshwater and saltwater aquatic microorganisms, algae, invertebrates, and fish. Phthalate esters have been tested with six species of microorganisms, including bacteria and protozoans. Fifteen algal species have been tested, including green and bluegreen algae in both freshwater and saltwater. Nineteen freshwater and saltwater invertebrate species inhabiting surface waters and sediments and 21 freshwater and saltwater fish inhabiting cold and warm water bodies have been tested. The results of most studies indicate that acute and chronic toxicity to microorganisms, algae, aquatic invertebrates, and fish are limited to the lower molecular weight phthalate esters (i.e., dimethyl‐, diethyl‐, diallyl‐, dipropyl‐, dibutyl‐, diisobutyl‐, and butylbenzylphthalate). In contrast, higher molecular weight phthalate esters are not acutely or chronically toxic to aquatic organisms. Although conflicting data on chronic effects for high molecular weight phthalate esters have been reported for daphnids, these inconsistencies are attributed to physical effects imposed on daphnids when exposed to test concentrations in excess of true water solubilities. Altogether, nearly 400 test results covering more than 60 species of microorganisms, algae, invertebrates, and fish are reported for both freshwater and saltwater aquatic species. While most investigators used several common species and standard protocols to assay conventional endpoints, many nontraditional species and toxicological endpoints were also used. This has created a toxicological database of both sufficient depth to compare many similar tests and sufficient breadth to encompass virtually all important types of aquatic habitats and classes of aquatic species.\u003C\u002Fjats:p>",{"EN":969},"Aquatic toxicity of eighteen phthalate esters",{"VOID":971},"[\"11278443025275129337\"]",{"VOID":973},"10.1002\u002Fetc.5620160507",[121],"https:\u002F\u002Fsetac.onlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fetc.5620160507",[977,994,1013,1032,1049,1064],{"id":978,"sortIndex":25,"researcher":24,"roles":979,"affiliations":980,"properties":989,"displayName":991,"givenName":24,"familyName":24},"0543f837-aa0a-4969-9702-f206fcd1e291",[],[981],{"id":982,"sortIndex":25,"affiliation":983,"properties":24},"b4d330fa-e377-490a-96e6-71f9cbb55902",{"id":982,"createTime":24,"updateTime":24,"relativeEntities":984,"slug":24,"properties":985,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":988,"statistic":24},[],{"title":986},{"EN":987},"Assessment Technologies, Inc., 10201 Lee Highway, Suite 305, Fairfax, Virginia 22030, USA",[],{"title":990,"openalex":992},{"EN":991},"Charles A. 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Marl Germany.",{},{"id":24,"text":1448,"url":24,"identifiers":1449},"Scholz N.1995.Determination of the effect of Vestinol C (DBP) on the growth ofScenedesmus subspicatus86.81. SAG. Complies with Directive 92\u002F69\u002FEEC. Final Report AW‐392. Huels AG Marl Germany.",{},{"id":24,"text":1451,"url":24,"identifiers":1452},"Hudson R. A., 1981, Phthalate ester hydrolases and phthalate ester toxicity in synchronously developing larvae of the brine shrimp (Artemia), Life Sci., 29, 1865, 10.1016\u002F0024-3205(81)90517-8",{"doi":1453},"10.1016\u002F0024-3205(81)90517-8",{"id":24,"text":1455,"url":24,"identifiers":1456},"10.1016\u002F0147-6513(83)90079-9",{"doi":1455},{"id":24,"text":1458,"url":24,"identifiers":1459},"10.1007\u002FBF01685335",{"doi":1458},{"id":24,"text":1461,"url":24,"identifiers":1462},"Volskay V. T., 1988, Toxicity of selected RCRA compounds to activated sludge microorganisms, JWPCF, 60, 1850",{},{"id":24,"text":1464,"url":24,"identifiers":1465},"ABC Laboratories1986.96‐hour flow‐through acute toxicity of butylbenzyl phthalate to the mayflyHexageniasp. Study 34173C. Monsanto St. Louis MO USA.",{},{"id":24,"text":1467,"url":24,"identifiers":1468},"ABC Laboratories1986.96‐hour flow‐through acute toxicity of butylbenzyl phthalate to the freshwater crayfishProcambarussp.Monsanto St. Louis MO USA.",{},{"id":24,"text":1470,"url":24,"identifiers":1471},"ABC Laboratories1986.96‐hour flow‐through acute toxicity of butylbenzyl phthalate toHydra littoralis. Study 34168. Monsanto St. Louis MO USA.",{},{"id":24,"text":1473,"url":24,"identifiers":1474},"Calvert C. W. J.AdamsandR. G.Mosher1982.Acute toxicity of Santicizer 160 toChironomus tentans. Environmental Sciences Report ES‐82‐SS‐79. Monsanto St. Louis MO USA.",{},{"id":24,"text":1476,"url":24,"identifiers":1477},"Springborn Bionomics1986.Chronic toxicity of butylbenzyl phthalate to mysid shrimp (Mysidophsis bahia). Final Report. Monsanto St. Louis MO USA.",{},{"id":24,"text":1479,"url":24,"identifiers":1480},"BASF A. G.1989.Labor Oekologie unveroeffentliche Untersuchung (01\u002F89\u002F026). Ludwigshafen Germany.",{},{"id":24,"text":1482,"url":24,"identifiers":1483},"BASF AG.1989.Labor Oekologie unveroeffentliche Untersuchung. (Sapromattest: Ergebnisuebersicht und Testbewertung vom 26.05.1983.) Ludwigshafen Germany.",{},{"id":24,"text":1485,"url":24,"identifiers":1486},"Scholz N.1995.Determination of the effect of Vestinol AH (DEHP) on the growth ofScenedesmus subspicatus86.81. SAG. Complies with Directive 92\u002F69\u002FEEC. Final Report AW‐391. Huels AG Marl Germany.",{},{"id":24,"text":1488,"url":24,"identifiers":1489},"10.1007\u002FBF01622278",{"doi":1488},{"id":24,"text":1491,"url":24,"identifiers":1492},"10.1080\u002F15287398409530553",{"doi":1491},{"id":24,"text":1494,"url":24,"identifiers":1495},"10.1016\u002F0045-6535(82)90046-7",{"doi":1494},{"id":24,"text":1497,"url":24,"identifiers":1498},"Guarino A. M., 1976, Distribution and toxicity of selected water pollutants in the spiny dogfish, Squalus acanthias, Bull. Mt. Desert Isl. Biol. Lab., 16, 50",{},{"id":24,"text":1500,"url":24,"identifiers":1501},"Croudace C. P., 1995, Chronic toxicity to Daphnia magna",{},{"id":24,"text":1503,"url":24,"identifiers":1504},"CITI., 1992, Biodegradation and bioaccumulation data of existing chemicals based on CSCL Japan",{},{"id":1506,"createTime":1507,"updateTime":1508,"relativeEntities":1509,"slug":1510,"properties":1511,"entityType":117,"verifyStatus":118,"verifyTime":1526,"verifyNote":119,"languages":1527,"translateLanguages":24,"viewCount":25,"primaryUrl":1528,"fullTextUrl":24,"authors":1529,"publicationType":187,"publisherRelationship":1597,"citationCount":1647,"citationInfo":1648,"publishDate":1651,"publishYear":1649,"citationAnalyzeStatus":1652,"lastCitationAnalyze":1653,"indexDatabases":1654,"openAccess":24,"references":1655,"isForceReanalyzing":284},"8bc72132-a546-4e0b-8142-8f7a56bc4bd3","2024-12-04T18:23:17.913+00:00","2026-07-08T00:00:37.410+00:00",[],"A-new-method-for-ranking-mode-specific-sensitivity-of-freshwater-arthropods-to-insecticides-and-its-relationship-to-biological-traits",{"mag":1512,"gsPaper":1514,"openalex":1516,"abstract":1518,"title":1520,"pm":1522,"doi":1524},{"VOID":1513},"2153584101",{"VOID":1515},"[]",{"VOID":1517},"W2153584101",{"EN":1519},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>The problem of how to deal with species sensitivity differences to toxic substances has been addressed successfully with the species sensitivity distribution (SSD), yet this has not increased understanding about the underlying mechanisms of sensitivity. Other researchers have identified the mode of action of chemicals and also biological traits of species as determinants for sensitivity, yet no systematic approach combines these factors. To achieve this, first existing data on organophosphate, carbamate, and pyrethroid toxicity and mode of action and also species trait information were mined. Second, we linked taxon sensitivity to their traits at the family level to generate empirical and mechanistic hypotheses about sensitivity–trait relationships. In this way, a mode‐specific sensitivity (MSS) ranking method was developed, and tested at the taxonomic level of family and genus. The application of several quality criteria indicated overall confidence in rankings, but confidence in exact taxon rank was less certain, due to data insufficiency for certain groups. The MSS rankings were found to be applicable for trait‐based approaches and were successfully linked to existing trait data to identify traits with predictive potential. Although this empirical analysis cannot test causality relationships between traits and sensitivity, testable hypotheses were generated, for further experimental investigation. Single traits as well as combinations of traits can be used to predict laboratory sensitivity to the substances tested, although associations were not as strong as in previous studies. We conclude that existing trait data are not suitable for every trait‐based research question and that important traits remain to be identified and quantified in relation to the processes of toxicity, i.e., the toxicokinetics and toxicodynamics. Environ. Toxicol. Chem. 2010;29:476–487. © 2009 SETAC\u003C\u002Fjats:p>",{"EN":1521},"A new method for ranking mode‐specific sensitivity of freshwater arthropods to insecticides and its relationship to biological traits",{"VOID":1523},"20821467",{"VOID":1525},"10.1002\u002Fetc.55","2024-12-04T18:23:17.912+00:00",[121],"https:\u002F\u002Fsetac.onlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fetc.55",[1530,1555,1574],{"id":1531,"sortIndex":25,"researcher":24,"roles":1532,"affiliations":1533,"properties":1550,"displayName":1552,"givenName":24,"familyName":24},"7e066320-94e5-4025-996d-9d670c697f7b",[],[1534,1542],{"id":1535,"sortIndex":25,"affiliation":1536,"properties":24},"813a2887-f2a7-4064-b483-4bdb4128259b",{"id":1535,"createTime":24,"updateTime":24,"relativeEntities":1537,"slug":24,"properties":1538,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1541,"statistic":24},[],{"title":1539},{"VI":1540},"Alterra, Wageningen University and Research Centre, P.O. Box 47, 6700 AA Wageningen, The Netherlands",[],{"id":1543,"sortIndex":147,"affiliation":1544,"properties":24},"98a87fc0-4f45-49fc-821e-0f1c002d0be1",{"id":1543,"createTime":24,"updateTime":24,"relativeEntities":1545,"slug":24,"properties":1546,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1549,"statistic":24},[],{"title":1547},{"VI":1548},"Department of Aquatic Ecology and Water Quality Management, Wageningen University, P.O. Box 47, 6700 AA Wageningen, The Netherlands",[],{"title":1551,"openalex":1553},{"EN":1552},"M.N. Rubach",{"VOID":1554},"A5015949140",{"id":1556,"sortIndex":147,"researcher":24,"roles":1557,"affiliations":1558,"properties":1567,"displayName":1571,"givenName":24,"familyName":24},"89139925-b667-4db4-ad3b-a71e5b21c8d9",[],[1559],{"id":1560,"sortIndex":25,"affiliation":1561,"properties":24},"30c2698d-9152-4091-a526-1db2b2c85ca6",{"id":1560,"createTime":24,"updateTime":24,"relativeEntities":1562,"slug":24,"properties":1563,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1566,"statistic":24},[],{"title":1564},{"EN":1565},"Environment Canada, Canadian Rivers Institute, Department of Biology, University of New Brunswick, P.O. Box 45111, Fredericton, New Brunswick E3B 6E1",[],{"orcid":1568,"title":1570,"openalex":1572},{"VOID":1569},"https:\u002F\u002Forcid.org\u002F0000-0003-4653-7906",{"EN":1571},"Donald J. 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Oregon State University Department of Entomology Corvallis OR USA.",{},{"id":24,"text":1717,"url":24,"identifiers":1718},"10.1051\u002Flimn\u002F1999014",{"doi":1717},{"id":24,"text":1720,"url":24,"identifiers":1721},"10.1046\u002Fj.1365-2427.2000.00535.x",{"doi":1720},{"id":24,"text":1723,"url":24,"identifiers":1724},"10.1111\u002Fj.1365-2427.1994.tb01742.x",{"doi":1723},{"id":24,"text":1726,"url":24,"identifiers":1727},"PayneRW HardingSA MurrayDA SoutarDM BairdDB GlaserAI ChanningIC WelhamSJ GilmourAR ThompsonR WebsterR.2008.GenStat for Windows Release 11.1 Reference Manual Part 3 Procedure Library PL19. 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A one‐compartment model was then used to investigate potential effects of metabolism on chemical bioaccumulation as a function of octanol\u002Fwater partitioning (\u003Cjats:italic>K\u003C\u002Fjats:italic>\u003Cjats:sub>OW\u003C\u002Fjats:sub>). In a second model‐based effort, in vitro data were incorporated into a physiologically based toxicokinetic (PBTK) model for fish. The two models predict similar effects on bioaccumulation when calculated in vivo intrinsic clearance values (CL\u003Cjats:sub>IN VIVO, INT\u003C\u002Fjats:sub> are less than 50% of estimated liver blood flow (\u003Cjats:italic>Q\u003C\u002Fjats:italic>\u003Cjats:sub>LIVER\u003C\u002Fjats:sub>). When CL\u003Cjats:sub>IN VIVO, INT\u003C\u002Fjats:sub> approaches \u003Cjats:italic>Q\u003C\u002Fjats:italic>\u003Cjats:sub>LIVER\u003C\u002Fjats:sub>, the PBTK model predicts a greater effect on bioaccumulation than the one‐compartment model. This result is attributed to the structure of the PBTK model, which provides for first‐pass clearance of chemicals taken up from food. Uncertainties inherent to in vitro‐in vivo extrapolations of hepatic metabolism data include the effects of protein binding, inaccurate estimation of in vivo metabolism by in vitro assays, and failure to account for metabolism in other tissues. Model‐based predictions of bioaccumulation within a natural setting also must account for possible metabolism at multiple trophic levels. The models described in this study can be used to perform in vitro–in vivo metabolism comparisons with fish, estimate in vitro biotransformation parameters on the basis of measured chemical residues in field‐collected animals, and calculate the level of in vitro metabolic activity required to limit bioaccumulation of all compounds to a specified value.\u003C\u002Fjats:p>",{"EN":1791},"In vitro‐in vivo extrapolation of quantitative hepatic biotransformation data for fish. II. Modeled effects on chemical bioaccumulation",{"VOID":1793},"17571698",{"VOID":1795},"10.1897\u002F06-259r.1",[121],"https:\u002F\u002Fsetac.onlinelibrary.wiley.com\u002Fdoi\u002F10.1897\u002F06-259R.1",[1799,1818,1833],{"id":1800,"sortIndex":25,"researcher":24,"roles":1801,"affiliations":1802,"properties":1811,"displayName":1815,"givenName":24,"familyName":24},"962bc5be-4e34-448c-a6f7-ded4b21c1324",[],[1803],{"id":1804,"sortIndex":25,"affiliation":1805,"properties":24},"6439da9c-cbcf-4354-8cdf-6a13df4e4d53",{"id":1804,"createTime":24,"updateTime":24,"relativeEntities":1806,"slug":24,"properties":1807,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1810,"statistic":24},[],{"title":1808},{"VI":1809},"U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Congdon Boulevard, Duluth, Minnesota 55804",[],{"orcid":1812,"title":1814,"openalex":1816},{"VOID":1813},"https:\u002F\u002Forcid.org\u002F0000-0003-0861-7788",{"EN":1815},"John W. 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The exposure of parental (F\u003Cjats:sub>0\u003C\u002Fjats:sub>) medaka to MT was begun on embryos within 12 h postfertilization and continued for up to 101 d; assessment endpoints included embryological development, hatching, posthatch survival, growth, sexual differentiation, reproduction, and hepatic vitellogenin (VTG) levels under flow‐through exposure to MT at each mean measured concentration of 0.35, 1.09, 3.29, 9.98, and 27.75 ng\u002FL. Eggs (F\u003Cjats:sub>1\u003C\u002Fjats:sub>) spawned from the F\u003Cjats:sub>0\u003C\u002Fjats:sub> fish at 98, 99, and 100 d posthatch were examined for hatchability, survival after hatching, growth, sexual differentiation, and hepatic VTG level until 60 d posthatch. In the FFLC with medaka, MT induced masculinization of both secondary sex characteristics and gonads. We observed that all F\u003Cjats:sub>0\u003C\u002Fjats:sub> fish in the 27.75‐ng\u002FL treatment group showed male secondary sex characteristics in which no fish with ovary could be discerned. Several fish with ovaries in F\u003Cjats:sub>0\u003C\u002Fjats:sub> and F\u003Cjats:sub>1\u003C\u002Fjats:sub> generations treated with 9.98 ng\u002FL showed male secondary sex characteristics. We also observed swollen abdomens in the F\u003Cjats:sub>0\u003C\u002Fjats:sub> and F\u003Cjats:sub>1\u003C\u002Fjats:sub> female fish in the 9.98‐ng\u002FL treatment group. These swollen abdomens were induced by enlarged ovaries and were accompanied with declined fecundity and fertility in the F\u003Cjats:sub>0\u003C\u002Fjats:sub> generation. 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Practically no data are available on the activity of individual PCBs or PBBs as carcinogens; however, considerable data exist on the activity of congeneric PCBs and PBBs as promoters\u002Finitiators of two‐stage hepatocarcinogenesis in the rat. The compounds studied were either acutely toxic (coplanar) biphenyl congeners, nonacutely toxic congeners or halogenated biphenyls with intermediate acute toxicity. Acutely toxic PCBs\u002FPBBs as well as those without acute toxicity and those with intermediate toxicity may all promote hepatocarcinogenesis in the rat, but probably by different mechanisms. The ability of congeneric PCBs and PBBs to stimulate cellular growth and division (mitogenic effects) on the one hand and\u002For hepatotoxic effects on the other most likely contributes to the carcinogenic effects seen. 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The age of individuals was not related to the blood concentrations for any of the four compounds, and in birds whose values were measured repeatedly, there was no effect of the length of time (number of years) between sampling events on the relative change in OC concentration. This indicates that steady‐state levels were reached before the age of first breeding. However, breeding area significantly influenced the changes in OC concentration between sampling events. In areas in which birds fed on prey from higher trophic levels, the OC concentrations showed large increases between sampling events; in areas in which birds fed at lower trophic levels, OC concentrations increased relatively little or not at all. This indicates that individual birds had different equilibrium concentrations, which are reached at different ages depending on the intake of OCs through the food. It also indicates that some individuals had not reached steady‐state concentrations at the onset of reproduction. Changes in body condition and amount of blood lipids were of lesser importance than trophic level and influenced the concentrations of HCB and oxychlordane more strongly than DDE and PCB‐153. In conclusion, this study indicates that steady‐state concentrations of persistent OCs are reached early in life in most glaucous gulls, considering the long life span of the species.\u003C\u002Fjats:p>",{"EN":2728},"Age and accumulation of persistent organochlorines: A study of arctic‐breeding glaucous gulls (\u003Ci>Larus hyperboreus\u003C\u002Fi>)",{"VOID":2730},"12959547",{"VOID":2732},"10.1897\u002F02-456",[121],"https:\u002F\u002Fsetac.onlinelibrary.wiley.com\u002Fdoi\u002F10.1897\u002F02-456",[2736,2753,2770,2787],{"id":2737,"sortIndex":25,"researcher":24,"roles":2738,"affiliations":2739,"properties":2748,"displayName":2750,"givenName":24,"familyName":24},"9ddd3232-ffcf-4989-b742-b05d9c1923d2",[],[2740],{"id":2741,"sortIndex":25,"affiliation":2742,"properties":24},"2b80f5b6-58ab-4bc2-9828-f5a335654852",{"id":2741,"createTime":24,"updateTime":24,"relativeEntities":2743,"slug":24,"properties":2744,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2747,"statistic":24},[],{"title":2745},{"EN":2746},"Norwegian Institute for Nature Research, Division of Arctic Ecology, The Polar Environmental Center, N-9296 Tromsø, Norway",[],{"title":2749,"openalex":2751},{"EN":2750},"Jan Ove Bustnes",{"VOID":2752},"A5014635096",{"id":2754,"sortIndex":147,"researcher":24,"roles":2755,"affiliations":2756,"properties":2765,"displayName":2767,"givenName":24,"familyName":24},"cb6895ed-9fbb-4b2b-af27-e215099d67d0",[],[2757],{"id":2758,"sortIndex":25,"affiliation":2759,"properties":24},"1eacaf99-8e25-4b99-918b-f24f4914fbe8",{"id":2758,"createTime":24,"updateTime":24,"relativeEntities":2760,"slug":24,"properties":2761,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2764,"statistic":24},[],{"title":2762},{"EN":2763},"Norwegian Polar Institute, c\u002Fo University of Oslo, Zoological Museum, Sarsgt. 1, N-0562 Oslo, Norway",[],{"title":2766,"openalex":2768},{"EN":2767},"Vidar Bakken",{"VOID":2769},"A5086765035",{"id":2771,"sortIndex":169,"researcher":24,"roles":2772,"affiliations":2773,"properties":2782,"displayName":2784,"givenName":24,"familyName":24},"6d20f000-6a40-4fce-a51e-ad1ddccfa114",[],[2774],{"id":2775,"sortIndex":25,"affiliation":2776,"properties":24},"dddbd561-a7e1-45b7-8bd8-0474beba86fe",{"id":2775,"createTime":24,"updateTime":24,"relativeEntities":2777,"slug":24,"properties":2778,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2781,"statistic":24},[],{"title":2779},{"EN":2780},"National Veterinary Institute, P.O. 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