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Science Citation Index Expanded",{"EN":60,"VI":61},"SCIE database","Cơ sở dữ liệu SCIE","scie",[64,65],"SCIE","ISI","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=1355-008X",[68],"7fc7f180-3918-45ab-8bea-b2226f5d88f6",{"id":70,"indexDatabase":71,"url":81,"indexYears":82,"academicFieldIds":83,"indexDatabaseRanking":86},"951d5cfb-c8cd-4cda-a834-15ece2e18d6e",{"id":72,"createTime":21,"updateTime":21,"relativeEntities":73,"label":74,"description":76,"key":78,"publicationTags":79,"standard":21},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9",[],{"EN":75,"VI":75},"Scopus - Elsevier",{"EN":75,"VI":77},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[80],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F78208","1993-2025",[84,85],"5b134d7d-51cf-4eea-aade-eaec47ba2837","1fbd0674-a1cb-4227-af17-9260dd767b86","SCOPUS__Q2",{"impactFactor":22,"impactFactorByYear":88,"i10Index":101,"i10IndexLast5Year":102,"totalPublication":103,"totalPublicationByYear":104,"totalCitation":135,"totalCitationByYear":136,"totalCitationPerPublication":158,"totalCitationPerPublicationByYear":159,"hindexLast5Year":181,"hindex":181},{"2012":89,"2013":90,"2014":91,"2015":92,"2016":93,"2017":94,"2018":95,"2019":96,"2020":97,"2021":98,"2022":99,"2023":100},0.59,0.52,0.39,0.41,0.43,0.46,0.56,0.6,0.61,0.68,0.67,0.58,710,142,9128,{"1995":105,"1996":106,"1997":107,"1998":108,"1999":109,"2000":110,"2001":111,"2002":112,"2003":113,"2004":114,"2005":115,"2006":116,"2007":117,"2008":118,"2009":119,"2010":120,"2011":121,"2012":122,"2013":123,"2014":124,"2015":125,"2016":126,"2017":127,"2018":128,"2019":129,"2020":130,"2021":131,"2022":132,"2023":133,"2024":134},239,116,176,111,112,120,178,139,171,131,164,145,124,119,258,211,241,413,408,521,473,589,448,468,509,546,600,499,445,202,25074,{"1995":137,"1996":138,"1997":139,"1999":140,"2006":141,"2007":142,"2008":143,"2009":144,"2010":145,"2011":146,"2012":147,"2013":148,"2014":149,"2015":150,"2016":151,"2017":152,"2018":153,"2019":154,"2020":155,"2021":156,"2022":157},485,81,1301,422,168,773,286,911,1100,1227,1681,1931,1690,1726,2417,2424,1541,1767,1086,1162,371,2.75,{"1995":160,"1996":161,"1997":162,"1999":163,"2006":164,"2007":165,"2008":166,"2009":167,"2010":168,"2011":169,"2012":170,"2013":171,"2014":172,"2015":173,"2016":174,"2017":175,"2018":176,"2019":177,"2020":178,"2021":179,"2022":180},2.03,0.7,7.39,3.77,1.16,6.23,2.4,3.53,5.21,5.09,4.07,4.73,3.24,3.65,4.1,5.41,3.29,3.47,1.99,1.94,0.74,64,"JOURNAL",{"meta":184,"data":186},{"total":185},"4025",[187,351,469,687,973,1266,1432,1816,1937,2187],{"id":188,"createTime":189,"updateTime":190,"relativeEntities":191,"slug":192,"properties":193,"entityType":203,"verifyStatus":204,"verifyTime":205,"verifyNote":206,"languages":21,"translateLanguages":207,"viewCount":22,"primaryUrl":209,"fullTextUrl":21,"authors":210,"publicationType":296,"publisherRelationship":297,"citationCount":21,"citationInfo":21,"publishDate":347,"publishYear":348,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":349,"openAccess":21,"references":21,"isForceReanalyzing":350},"02cd4f77-0a96-4e8b-ad21-087584a12fec","2024-02-12T02:02:42.682+00:00","2026-09-10T06:13:21.121+00:00",[],"The-effect-of-gonadotropin-inhibitory-hormone-on-steroidogenesis-and-spermatogenesis-by-acting-through-the-hypothalamic-pituitary-testis-axis-in-mice",{"abstract":194,"title":196,"references":199,"doi":201},{"EN":195},"Gonadotropin inhibitory hormone (GnIH) is essential for regulating the reproduction of mammals and inhibiting testicular activities in mice. This study aimed to explore the mechanism of GnIH on spermatogenesis and steroidogenesis by acting through the hypothalamus-pituitary-testis axis of mice. Mice were subcutaneously injected with different doses of GnIH (1 μg\u002F150 μL, 3 μg\u002F150 μL, 6 μg\u002F150 μL, 150 μL saline, twice daily) for 11 days. Subsequently, luteinizing hormone (LH), testosterone (T), and inhibin B (INH B) levels of peripheral blood were determined, and the expression of GnRH synthesis-related genes (GnRH-1, Kiss-1, NPY) and gonadotropin synthesis-related genes (FSH β, LH β, GnRH receptor) in the hypothalamus and pituitary gland were respectively detected. Additionally, the expression of steroidogenesis-related genes\u002Fproteins (P450scc, StAR and 3β-HSD) and spermatogenesis-related proteins\u002Fgenes including LH receptor (LHR), androgen receptor (AR), heat shock factor-2 (HSF-2) and INH B were analyzed using western blot and q-PCR. Results showed that GnIH treatment significantly reduced the concentration of LH in the peripheral blood. Further analysis revealed that GnIH treatment markedly reduced the expression of GnRHImRNA and Kiss-1 mRNA in the hypothalamus, and mRNA levels of FSH β, LH β, and GnRHR genes in the pituitary. We also observed that GnIH treatment significantly decreased T levels and expression of the P450scc, StAR, and 3β-HSD proteins in the testis. Furthermore, GnIH treatment down-regulated LHR, AR proteins, and HSF-2 gene in the testis. Importantly, the INH B concentration of and INH βb mRNA levels significantly declined following GnIH treatment. Additionally, GnIH treatment may induce germ cell apoptosis in the testis of mice. In conclusion, GnIH may suppress spermatogenesis and steroidogenesis by acting through the hypothalamus-pituitary-testis axis in mice.",{"EN":197,"VI":198},"The effect of gonadotropin-inhibitory hormone on steroidogenesis and spermatogenesis by acting through the hypothalamic–pituitary–testis axis in mice","Tác động của hormone ức chế gonadotropin lên quá trình sinh steroid và sinh tinh thông qua tác động lên trục dưới đồi–tuyến yên–tinh hoàn ở chuột nhắt",{"VOID":200},"R.W. Holdcraft, R.E. Braun, Hormonal regulation of spermatogenesis. Int. J. Androl. 27, 335–342 (2004)\nK. Tsutsui, E. Saigoh, K. Ukena, H. Teranishi, Y. Fujisawa et al. A novel avian hypothalamic peptide inhibiting gonadotropin release. Biochem. Biophys. Res. Commun. 275, 661–667 (2000)\nK. Tsutsui, T. Osugi, Y.L. Son, T. Ubuka, Review: Structure, function and evolution of GnIH. Gen. Comp. Endocrinol. 264, 48–57 (2018)\nK. Tsutsui, T. Ubuka, Discovery of gonadotropin-inhibitory hormone (GnIH), progress in GnIH research on reproductive physiology and behavior and perspective of GnIH research on neuroendocrine regulation of reproduction. Mol. Cell Endocrinol. 514, 110914 (2020)\nK. Tsutsui, T. Ubuka, Gonadotropin-inhibitory hormone (GnIH): a new key neurohormone controlling reproductive physiology and behavior. Front. Neuroendocrinol. 61, 100900 (2021)\nI.J. Clarke, Y. Qi, I.P. Sari, J.T. Smith, Evidence that RF-amide related peptides are inhibitors of reproduction in mammals. Front. Neuroendocrinol. 30, 371–378 (2009)\nI. Parhar, S. Ogawa, T. Kitahashi, RFamide peptides as mediators in environmental control of GnRH neurons. Prog. Neurobiol. 98, 176–196 (2012)\nG.E. Bentley, N. Perfito, K. Ukena, K. Tsutsui, J.C. Wingfield, Gonadotropin-inhibitory peptide in song sparrows (Melospiza melodia) in different reproductive conditions, and in house sparrows (Passer domesticus) relative to chicken-gonadotropin-releasing hormone. J. Neuroendocrinol. 15, 794–802 (2003)\nM.A. Johnson, K. Tsutsui, G.S. Fraley, Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat. Horm. Behav. 51, 171–180 (2007)\nM.Z. Rizwan, M.C. Poling, M. Corr, P.A. Cornes, R.A. Augustine, J.H. Quennell et al. RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action. Endocrinology 153, 3770–3779 (2012)\nS. Hinuma, Y. Shintani, S. Fukusumi, N. Iijima, Y. Matsumoto et al. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat. Cell Biol. 2, 703–708 (2000)\nE.M. Gibson, S.A. Humber, S. Jain, W.P. Williams, S. Zhao, G.E. Bentley et al. Alterations in RFamide-related peptide expression are coordinated with the preovulatory luteinizing hormone surge. Endocrinology 149, 4958–4969 (2008)\nY.L. Son, T. Ubuka, R.P. Millar, H. Kanasaki, K. Tsutsui, Gonadotropin-inhibitory hormone inhibits GnRH-induced gonadotropin subunit gene transcriptions by inhibiting AC\u002FcAMP\u002FPKA-dependent ERK pathway in LβT2 cells. Endocrinology 153, 2332–2343 (2012)\nT. Ubuka, K. Morgan, A.J. Pawson, T. Osugi, V.S. Chowdhury et al. Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary Axis. PLoS ONE 4, e8400 (2009)\nN.A. Ciccone, I.C. Dunn, T. Boswell, K. Tsutsui, T. Ubuka et al. Gonadotrophin inhibitory hormone depresses gonadotrophin α and follicle-stimulating hormone β subunit expression in the pituitary of the domestic chicken. J. Neuroendocrinol. 16, 999–1006 (2004)\nT. Ubuka, K. Ukena, P.J. Sharp, G.E. Bentley, K. Tsutsui, Gonadotropin-inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail. Endocrinology 147, 1187–1194 (2006)\nH. Kadokawa, M. Shibata, Y. Tanaka, T. Kojima, M. Matsumoto et al. Bovine C-terminal octapeptide of RFamide-related peptide-3 suppresses luteinizing hormone (LH) secretion from the pituitary as well as pulsatile LH secretion in bovines. Domest. Anim. Endocrinol. 36, 219–224 (2009)\nX. Li, J. Su, R. Fang, L. Zheng, R. Lei et al. The effects of RFRP-3, the mammalian ortholog of GnIH, on the female pig reproductive axis in vitro. Mol. Cell Endocrinol. 372, 65–72 (2013)\nR. Pineda, D. Garcia-Galiano, M.A. Sanchez-Garrido, M. Romero, F. Ruiz-Pino et al. Characterization of the inhibitory roles of RFRP3, the mammalian ortholog of GnIH, in the control of gonadotropin secretion in the rat: in vivo and in vitro studies. Am. J. Physiol. Endocrinol. Metab. 299, E39–E46 (2010)\nI.P. Sari, A. Rao, J.T. Smith, A.J. Tilbrook, I.J. Clarke, Effect of RF-Amide-related peptide-3 on luteinizing hormone and follicle-stimulating hormone synthesis and secretion in ovine pituitary gonadotropes. Endocrinology 150, 5549–5556 (2009)\nI.J. Clarke, I.P. Sari, Y. Qi, J.T. Smith, H.C. Parkington et al. Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology 149, 5811–5821 (2008)\nS. Anjum, A. Krishna, K. Tsutsui, Inhibitory roles of the mammalian GnIH ortholog RFRP3 in testicular activities in adult mice. J. Endocrinol. 223, 79–91 (2014)\nK. Ubuka, L.Y. Son, Y. Tobari, M. Narihiro, G.E. Bentley, L.G. Kriegsfeld et al. Central and direct regulation of testicular activity by gonadotropin-inhibitory hormone and its receptor. Front. Endocrinol. 5, 8 (2014)\nL. Han, C.J. Wu, H.S. Riazz, L.Y. Bai, J.G. Chen et al. Characterization of the mechanism of inhibin a-subunit gene in mouse anterior pituitary cells by RNA interference. Plos One 8, e74596 (2013)\nR.J. Shao, F.P. Zhang, F. Tian, P.A. Friberg, X.Y. Wang et al. Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo. FEBS Lett. 569, 293–300 (2004)\nT. Ubuka, S. Kim, Y.C. Huang, J. Reid, J. Jiang et al. Gonadotropin-inhibitory hormone neurons interact directly with gonadotropin-releasing hormone-I and -II neurons in European starling brain. Endocrinology 149, 268–278 (2008)\nX.H. Han, Y.Y. He, G.L. Zeng, Y.H. Wang, W. Sun et al. Intracerebroventricular injection of RFRP-3 delays puberty onset and stimulates growth hormone secretion in female rats. Reprod. Biol. Endocrinol. 15, 35 (2017)\nM. Murakami, T. Matsuzaki, T. Iwasa, T. Yasui, M. Irahara et al. Hypophysiotropic role of RFamide-related peptide-3 in the inhibition of LH secretion in female rats. J. Endocrinol. 199, 105–112 (2008)\nM. Sivalingam, S. Ogawa, V.L. Trudeau, I.S. Parhar, Conserved functions of hypothalamic kisspeptin in vertebrates. Gen. Comp. Endocrinol. 317, 113973 (2022)\nV. Sobrino, M.S. Avendaño, C. Perdices-López, M. Jimenez-Puyer, Tena-Sempere, M, Kisspeptins and the neuroendocrine control of reproduction: recent progress and new frontiers in kisspeptin research. Front. Neuroendocrinol. 65, 100977 (2022)\nE. Terasawa, Mechanism of pulsatile GnRH release in primates: unresolved questions. Mol. Cell Endocrinol. 498, 110578 (2019)\nI.J. Clarke, J.T. Smith, B.A. Henry, B.J. Oldfield, A. Stefanidis et al. Gonadotropin-inhibitory hormone is a hypothalamic peptide that provides a molecular switch between reproduction and feeding. Neuroendocrinology 95, 305–316 (2012)\nM.K. Herde, K. Geist, R.E. Campbell, A.E. Herbison, Gonadotropin-releasing hormone neurons extend complex highly branched dendritic trees outside the blood-brain barrier. Endocrinology 152, 3832–3841 (2011)\nW.A. Banks, M. Goulet, J.R. Rusche, M.L. Niehoff, R. Boismenu, Differential transport of a secretin analog across the blood-brain and blood-cerebrospinal fluid barriers of the mouse. J. Pharm. Exp. Ther. 302, 1062–1069 (2002)\nD. Dogrukol-Ak, F. Tore, N. Tuncel, Passage of VIP\u002FPACAP\u002Fsecretin family across the blood-brain barrier: therapeutic effects. Curr. Pharm. Des. 10, 1325–1340 (2004)\nA. Caraty, D. Lomet, M.E. Sébert, D. Guillaume, M. Beltramo, N.P. Evans, Gonadotrophin-releasing hormone release into the hypophyseal portal blood of the ewe mirrors both pulsatile and continuous intravenous infusion of kisspeptin: an insight into kisspeptin’s mechanism of action. J. Neuroendocrinol. 25, 537–546 (2013)\nJ.T. George, M. Hendrikse, J.D. Veldhuis, I.J. Clarke, R.A. Anderson et al. Effect of gonadotropin inhibitory hormone (GnIH) on luteinizing hormone secretion in humans. Clin. Endocrinol. 86, 731–738 (2017)\nP. Singh, A. Krishna, R. 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Mivechi, Targeted disruption of the heat shock transcription factor (hsf)-2 gene results in increased embryonic lethality, neuronal defects, and reduced spermatogenesis. Genesis 36(1), 48–61 (2003)\nJ. Liu, M.B. Rone, V. Papadopoulos, Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis. J. Biol. Chem. 281, 38879–38893 (2006)\nD.M. Stocco, X. Wang, Y. Jo, P.R. Manna, Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: more complicated than we thought. Mol. Endocrinol. 19, 2647–2659 (2005)\nF.P. Zhang, T. Pakarainen, M. Poutanen, J. Toppari, I. Huhtaniemi, The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis. Proc. Natl Acad. Sci. 100, 13692–13697 (2003)\nL.X. Shan, C.W. Bardin, M.P. Hardy, Immunohistochemical analysis of androgen effects on androgen receptor expression in developing Leydig and Sertoli cells. 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(Health Sci.) 37(5), 501–503 (2005)",{"VOID":202},"10.1007\u002Fs12020-024-03690-x","PUBLICATION","VERIFIED","2025-02-13T11:40:34.610+00:00","Auto Verify",[208],"VI","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs12020-024-03690-x",[211,227,243,257,273],{"id":212,"sortIndex":22,"researcher":21,"roles":213,"affiliations":215,"properties":224,"displayName":226,"givenName":21,"familyName":21},"a9d5abaa-ab77-41f9-929b-16025095b261",[214],"AUTHOR",[216],{"id":217,"sortIndex":22,"affiliation":218,"properties":21},"a24f65b7-6b73-4f44-8169-9120be05fdf3",{"id":217,"createTime":21,"updateTime":21,"relativeEntities":219,"slug":21,"properties":220,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":223,"statistic":21},[],{"title":221},{"VI":222},"College of Animal Science and Technology, Ningxia University, Yinchuan, China",[],{"title":225},{"VI":226},"Tianshu Dai",{"id":228,"sortIndex":229,"researcher":21,"roles":230,"affiliations":231,"properties":240,"displayName":242,"givenName":21,"familyName":21},"05f1406d-8ed8-485e-b213-75ec1367b4dd",1,[214],[232],{"id":233,"sortIndex":22,"affiliation":234,"properties":21},"49f3f5cb-162a-40c5-a112-ed232795ac2d",{"id":233,"createTime":21,"updateTime":21,"relativeEntities":235,"slug":21,"properties":236,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":239,"statistic":21},[],{"title":237},{"VI":238},"The Center of Laboratory Animals of Ningxia Medical University, Yinchuan, China",[],{"title":241},{"VI":242},"Li Yang",{"id":244,"sortIndex":245,"researcher":21,"roles":246,"affiliations":247,"properties":254,"displayName":256,"givenName":21,"familyName":21},"c8aa4946-22e1-41ca-8e6e-8ee212441f00",2,[214],[248],{"id":217,"sortIndex":22,"affiliation":249,"properties":21},{"id":217,"createTime":21,"updateTime":21,"relativeEntities":250,"slug":21,"properties":251,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":253,"statistic":21},[],{"title":252},{"VI":222},[],{"title":255},{"VI":256},"Shihao Wei",{"id":258,"sortIndex":259,"researcher":21,"roles":260,"affiliations":261,"properties":270,"displayName":272,"givenName":21,"familyName":21},"c6ad814e-a710-45fc-a9ac-3c0aa8c59567",3,[214],[262],{"id":263,"sortIndex":22,"affiliation":264,"properties":21},"bf4053c7-e08b-457e-97a1-d0e66a5f322e",{"id":263,"createTime":21,"updateTime":21,"relativeEntities":265,"slug":21,"properties":266,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":269,"statistic":21},[],{"title":267},{"VI":268},"Department of Laboratory Medicine, General Hospital of Ningxia Medical University, Yinchuan, China",[],{"title":271},{"VI":272},"Yuankui Chu",{"id":274,"sortIndex":275,"researcher":21,"roles":276,"affiliations":277,"properties":293,"displayName":295,"givenName":21,"familyName":21},"af9ed93f-460e-4310-aaea-247e9e72c31e",4,[214],[278,284],{"id":217,"sortIndex":22,"affiliation":279,"properties":21},{"id":217,"createTime":21,"updateTime":21,"relativeEntities":280,"slug":21,"properties":281,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":283,"statistic":21},[],{"title":282},{"VI":222},[],{"id":285,"sortIndex":229,"affiliation":286,"properties":292},"6d5bbcae-4c7c-45fd-b055-6fd8128aa75f",{"id":285,"createTime":21,"updateTime":21,"relativeEntities":287,"slug":21,"properties":288,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":291,"statistic":21},[],{"title":289},{"VI":290},"Ningxia Province’s Key Laboratory of Animal Cell and Molecular Breeding, Yinchuan, China",[],{},{"title":294},{"VI":295},"Xingang Dan","ARTICLE",{"url":209,"publisher":298,"properties":344},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":299,"slug":10,"properties":300,"entityType":19,"verifyStatus":20,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":22,"subjectFields":304,"manageAffiliations":313,"indexDatabases":324,"url":21,"thumbnailPath":21,"statistic":339,"gsStatistic":21,"type":182,"analyzePriority":21},[],{"issn":301,"title":302,"eissn":303},{"VOID":15},{"EN":10},{"VOID":13},[305,309],{"id":25,"createTime":21,"updateTime":21,"relativeEntities":306,"label":307,"description":308,"parentId":21,"standard":21,"scholarHubFieldId":21},[],{"EN":28},{},{"id":31,"createTime":21,"updateTime":21,"relativeEntities":310,"label":311,"description":312,"parentId":21,"standard":21,"scholarHubFieldId":21},[],{"EN":34},{},[314,319],{"id":38,"createTime":21,"updateTime":21,"relativeEntities":315,"slug":21,"properties":316,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":318,"statistic":21},[],{"title":317},{"EN":42},[],{"id":45,"createTime":21,"updateTime":21,"relativeEntities":320,"slug":21,"properties":321,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":323,"statistic":21},[],{"title":322},{"EN":49},[],[325,332],{"id":53,"indexDatabase":326,"url":66,"indexYears":21,"academicFieldIds":331,"indexDatabaseRanking":21},{"id":55,"createTime":21,"updateTime":21,"relativeEntities":327,"label":328,"description":329,"key":62,"publicationTags":330,"standard":21},[],{"EN":58,"VI":58},{"EN":60,"VI":61},[64,65],[68],{"id":70,"indexDatabase":333,"url":81,"indexYears":82,"academicFieldIds":338,"indexDatabaseRanking":86},{"id":72,"createTime":21,"updateTime":21,"relativeEntities":334,"label":335,"description":336,"key":78,"publicationTags":337,"standard":21},[],{"EN":75,"VI":75},{"EN":75,"VI":77},[80],[84,85],{"impactFactor":22,"impactFactorByYear":340,"i10Index":101,"i10IndexLast5Year":102,"totalPublication":103,"totalPublicationByYear":341,"totalCitation":135,"totalCitationByYear":342,"totalCitationPerPublication":158,"totalCitationPerPublicationByYear":343,"hindexLast5Year":181,"hindex":181},{"2012":89,"2013":90,"2014":91,"2015":92,"2016":93,"2017":94,"2018":95,"2019":96,"2020":97,"2021":98,"2022":99,"2023":100},{"1995":105,"1996":106,"1997":107,"1998":108,"1999":109,"2000":110,"2001":111,"2002":112,"2003":113,"2004":114,"2005":115,"2006":116,"2007":117,"2008":118,"2009":119,"2010":120,"2011":121,"2012":122,"2013":123,"2014":124,"2015":125,"2016":126,"2017":127,"2018":128,"2019":129,"2020":130,"2021":131,"2022":132,"2023":133,"2024":134},{"1995":137,"1996":138,"1997":139,"1999":140,"2006":141,"2007":142,"2008":143,"2009":144,"2010":145,"2011":146,"2012":147,"2013":148,"2014":149,"2015":150,"2016":151,"2017":152,"2018":153,"2019":154,"2020":155,"2021":156,"2022":157},{"1995":160,"1996":161,"1997":162,"1999":163,"2006":164,"2007":165,"2008":166,"2009":167,"2010":168,"2011":169,"2012":170,"2013":171,"2014":172,"2015":173,"2016":174,"2017":175,"2018":176,"2019":177,"2020":178,"2021":179,"2022":180},{"pages":345},{"VOID":346},"1-12","2024-01-29",2024,[86,64],false,{"id":352,"createTime":353,"updateTime":354,"relativeEntities":355,"slug":356,"properties":357,"entityType":203,"verifyStatus":204,"verifyTime":367,"verifyNote":206,"languages":21,"translateLanguages":368,"viewCount":22,"primaryUrl":369,"fullTextUrl":21,"authors":370,"publicationType":296,"publisherRelationship":414,"citationCount":21,"citationInfo":21,"publishDate":466,"publishYear":467,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":468,"openAccess":21,"references":21,"isForceReanalyzing":350},"200913ef-aa60-43c2-a6e4-ff6f7dc94b0b","2023-12-04T15:58:36.017+00:00","2026-09-09T09:13:16.171+00:00",[],"Effects-of-luteinizing-hormone-and-prostaglandin-F2%CE%B1-on-gap-junctional-intercellular-communication-of-ovine-luteal-cells-throughout-the-estrous-cycle",{"abstract":358,"title":360,"references":363,"doi":365},{"EN":359},"Cellular interactions mediated by contact-dependent pathways may be important to maintain luteal function. The objective of the present experiment was to evaluate the role of LH and prostaglandin F2α (PGF) in regulation of contact-dependent, gap junctional intercellular communication (GJIC) of ovine luteal cells from several stages of luteal development. Corpora lutea (CL) obtained from superovulated ewes on days 5 (n=7), 10 (n=8), and 15 (n=9) after estrus were dispersed with collagenase and cell types were separated by elutriation. Cells were plated as a mixed population (nonelutriated), or as small or large luteal cell fractions, and incubated in serum-free media containing no hormone, LH (100 ng\u002FmL), PGF (100 ng\u002FmL), LH+PGF, or dibutyryl cAMP (dbcAMP; 2 mM) for 18–24 h. Media were collected for evaluation of progesterone (P4) concentrations and replaced with media containing fluorescent dye. Then the rate of GJIC was evaluated by using the fluorescence recovery after photobleaching technique and laser cytometry. The rate of GJIC was determined for selected cells: small luteal cells in contact only with small luteal (S-S) cells; large luteal cells in contact only with small luteal (L-S) cells; and large luteal cells in contact only with large luteal (L-L) cells. LH increased (p\u003C0.01) GJIC for S-S on d 5 and 10 and for L-S cells across the estrous cycle, but did not affect GJIC for L-L cells. PGF increased (p\u003C0.05) GJIC for L-L cells on d 10 and 15, and decreased (p\u003C0.05) GJIC for S-S cells from d 5 and 10 of the estrous cycle. LH+PGF increased (p\u003C0.05) GJIC for S-S cells on d 5 and 10, and for L-S and L-L cells on d 10 and 15 of the estrous cycle. In addition, PGF diminished (p\u003C0.05) LH-stimulatory effects on GJIC for S-S cells from d 5 and 10, and for L-S cells from d 5 of the estrous cycle. Dibutyryl cAMP stimulated (p\u003C0.05) GJIC between all evaluated cell types across the estrous cycle. LH and dbcAMP stimulated (p\u003C0.05) P4 secretion by mixed and small luteal cell fractions, PGF alone did not affect basal P4 secretion, but LH+PGF stimulated (p\u003C0.05) P4 production by small luteal cells across the estrous cycle. PGF diminished (p\u003C0.05) LH-stimulatory effects on P4 production in mixed populations of luteal cells across the estrous cycle. These data demonstrate that both luteal cell types communicate with each other, and the rate of communication was affected by LH, PGF, and dbcAMP. Modulation of gap junctional contact-dependent intercellular communication may be an important mechanism by which regulatory signals are transduced during luteal growth, differentiation, and regression in sheep.",{"EN":361,"VI":362},"Effects of luteinizing hormone and prostaglandin F2α on gap junctional intercellular communication of ovine luteal cells throughout the estrous cycle","Tác động của hormon hoàng thể hóa và prostaglandin F2α lên truyền thông liên bào qua mối nối hở của tế bào hoàng thể cừu trong suốt chu kỳ động dục",{"VOID":364},"Ackland, J. F., Schwartz, N. B., Mayo, K. E., and Dadson, R. E. (1992).Physiol. Rev. 72, 731–787.\nAgrawal, R. and Daniel, E. E. (1986).Am. J. Physiol. 250, C495-C505.\nArchbald, L. F., Al-Bagdadi, F. and Godke, R. A. (1981).Theriogenology 16, 27–37.\nBalapure, A. K., Caicedo I. C., Kawada, K., Watt, D. S., Rexroad, C. E., and Fitz, T. A. (1989).Biol. Reprod. 41, 385–392.\nBraden, T. D., Gamboni, F., and Niswender, G. D. (1988).Biol. Reprod. 39, 245–253.\nBurghardt, R. C. and Anderson, E. (1981).Cell Tissue Res. 214, 181–193.\nBurghardt, R. C., Barhoumi, R., Sewall, T. C., and Bowen, J. A. (1995).J. Membrane Biol. 148, 243–253.\nChegini, N., Lei, Z. M., Rao, Ch. V., and Hansel, W. (1991).Biol. Reprod. 45, 506–513.\nConley, A. L. and Ford, S. P. (1989).Biol. Reprod. 40, 1224–1230.\nCronier, L., Bastide, B., Hervé, J. C., Délèze, J., and Malassiné, A. (1994).Endocrinology 135, 402–408.\nCuster, E. E., Lamsa, J. C., Eldering, J. A., and McCracken, J. A. (1995).Endocrine 3, 761–764.\nDel Vecchio, R. P., Thibodeaux, J. K., and Hansel, W. (1995).Dom. Anim. Endocrinol. 12, 25–33.\nEvrard, M., Leboulleux, P., and Hermier, C. (1978).Prostaglandins 16, 491–502.\nFarin, C. E., Moeller, C. L., Sawyer, H. R., Gamboni, F., and Niswender, G. D. (1986).Biol. Reprod. 35, 1299–1308.\nFitz, T. A., Mayan, M. H., Sawyer, H. R., and Niswender, G. D. (1982).Biol. Reprod. 27, 703–711.\nFitz, T. A., Mock, E. J., Mayan, M. H., and Niswender, G. D. (1984).Prostaglandins 28, 127–138.\nFletcher, P. W. and Niswender, G. D. (1982).Prostaglandins 23, 803–818.\nGarfield, R. E., Kannan, M. S., and Daniel, E. E. (1980).Am. J. Physiol. 238, C81-C89.\nGirsh, E., Greber, Y., and Meidan, R. (1995).Biol. Reprod. 52, 954–962.\nGoodman, R. L. (1994). In:The Physiology of Reproduction, Knobil, E. and Neill, J. D. (eds.) 2nd Edition, Raven: New York, pp. 659–709.\nGrazul-Bilska, A. T., Jablonka-Shariff, A., Bilski, J. J., Doraiswamy, V., Redmer, D. A., and Reynolds, L. P. (1996a).Biol. Reprod. 54(Suppl. 1), 161.\nGrazul-Bilska, A. T., Redmer, D. A., and Reynolds, L. P. (1991).J. Anim. Sci. 69, 2099–2107.\nGrazul-Bilska, A. T., Redmer, D. A., Jablonka-Shariff, A., Biondini, M. E., and Reynolds, L. P. (1995).Can. J. Physiol. Pharmacol. 73, 491–500.\nGrazul-Bilska, A. T., Reynolds, L. P., Jablonka-Shariff, A., and Redmer, D. A. (1994).Assisted Reprod. Technol.\u002FAndrol. 6, 264–286.\nGrazul-Bilska, A. T., Reynolds, L. P., Kirsch, J. D., and Redmer, D. A. (1996d).Biol. Reprod. 54, 538–545.\nGrazul-Bilska, A. T., Reynolds, L. P., Kirsch, J. D., Bilski, J. J., and Redmer, D. A. (1996c).Prostaglandins 52 (in press).\nGrazul-Bilska, A. T., Redmer, D. A., Johnson, M. L., Jablonka-Shariff, A., Bilski, J., and Reynolds, L. P. (1996b).Biol. Reprod. 54, 1279–1287.\nHansel, W., Alila, H. A., Dowd, J. P., and Milvae, R. A. (1991).J. Reprod. Fertil. 43, (Suppl), 77–89.\nHarrison, L. M., Kenny, N., and Niswender, G. D. (1987).J. Reprod. Fertil. 79, 539–548.\nHild-Petito, S., Ottobre, A. C., and Hoyer, P. B. (1987).J. Reprod. Fertil. 80, 537–544.\nHolder, J. W., Elmore, E., and Barrett, J. C. (1993).Canc. Res. 53, 3475–3485.\nHoyer, P. B. and Niswender, G. D. (1985).Can. J. Physiol. Pharmacol. 63, 240–248.\nHoyer, P. B., Fitz, T. A., and Niswender, G. D. (1984).Endocrinology 114, 604–608.\nInskeep, E. K. (1973).J. Anim. Sci. 36, 1149–1157.\nJablonka-Shariff, A., Fricke, P. M., Grazul-Bilska, A. T., Reynolds, L. 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(1990).Endocrinology 127, 3029–3037.\nWiltbank, M. C., Diskin, M. G., and Niswender, G. D. (1991).J. Reprod. Fertil. 43 (Suppl.), 65–75.\nWiltbank, M. C., Shiao, T. F., Bergfelt, D. R., and Ginther, O. J. (1995).Biol. Reprod. 52, 74–78.\nWiltbank, M. C. (1994).J. Anim. Sci. 72, 1873–1883.\nZheng, J., Fricke, P. M., Reynolds, L. P., and Redmer, D. A. (1994).Biol. Reprod. 51, 623–632.",{"VOID":366},"10.1007\u002FBF02738710","2025-02-03T04:14:59.118+00:00",[208],"http:\u002F\u002Flink.springer.com\u002F10.1007\u002FBF02738710",[371,386,401],{"id":372,"sortIndex":22,"researcher":21,"roles":373,"affiliations":374,"properties":383,"displayName":385,"givenName":21,"familyName":21},"fc7d4584-4b9d-4420-8ba3-98319ac2c859",[214],[375],{"id":376,"sortIndex":22,"affiliation":377,"properties":21},"f900d622-c451-4f11-8ecd-b3caa6f7c982",{"id":376,"createTime":21,"updateTime":21,"relativeEntities":378,"slug":21,"properties":379,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":382,"statistic":21},[],{"title":380},{"VI":381},"Cell Biology Center, North Dakota State University, Fargo",[],{"title":384},{"VI":385},"Anna T. 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We enrolled 553 DTC patients who underwent total thyroidectomy and categorized them into two groups according to their response to RAI therapy: excellent response (ER) and non-ER groups. Clinical and pathological characteristics of the patients were collected and retrospectively analyzed using univariate and multivariate binary logistic regression. Receiver operating characteristic (ROC) curves and diagnostic cutoff values were analyzed to assess the predictive value of important quantitative influences on 131I treatment outcomes. A new nomogram model was developed based on the above independent risk factors. R software was used to develop nomograms with all the independent prognostic factors included. The multivariate analysis showed that lymph node metastasis (LNM), stimulated thyroglobulin (sTg), thyroglobulin antibodies (TgAb), and sTg\u002Fthyroid-stimulating hormone (TSH) were significantly associated with non-ER of DTC patients. In the training set, the consistency index (C-index) of the new column line graph was 0.868 (95% CI 0.865-0.871). We proposed a new nomogram to predict non-ER for DTC with excellent discrimination and calibration.",{"EN":479,"VI":480},"A novel nomogram integrated with preablation stimulated thyroglobulin and thyroglobulin\u002Fthyroid-stimulating hormone ratio to predict the therapeutic response of intermediate‑ and high‑risk differentiated thyroid cancer patients: a bi-center retrospective study","Nomogram mới tích hợp thyroglobulin kích thích trước triệt căn và tỷ lệ thyroglobulin\u002Fhormon kích thích tuyến giáp để dự đoán đáp ứng điều trị ở bệnh nhân ung thư tuyến giáp biệt hoá nguy cơ trung bình và cao: một nghiên cứu hồi cứu hai trung 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Chen, B.H.H. Lang, D.S.A. Mcleod et al. Thyroid cancer. Lancet 401(10387), 1531–1544 (2023). https:\u002F\u002Fdoi.org\u002F10.1016\u002Fs0140-6736(23)00020-x",{"id":21,"text":616,"url":21,"identifiers":21},"J.D. Lin, C. Hsueh, T.C. Chao, Long-term follow-up of the therapeutic outcomes for papillary thyroid carcinoma with distant metastasis. Medicine 94(26), e1063 (2015). https:\u002F\u002Fdoi.org\u002F10.1097\u002Fmd.0000000000001063",{"id":21,"text":618,"url":21,"identifiers":21},"M. Schlumberger, S. Leboulleux, Current practice in patients with differentiated thyroid cancer. Nat. Rev. Endocrinol. 17(3), 176–188 (2021). https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41574-020-00448-z",{"id":21,"text":620,"url":21,"identifiers":21},"B.R. Haugen, E.K. Alexander, K.C. Bible et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 26(1), 1–133 (2016). https:\u002F\u002Fdoi.org\u002F10.1089\u002Fthy.2015.0020",{"id":21,"text":622,"url":21,"identifiers":21},"C. Sparano, S. Moog, J. Hadoux et al. Strategies for radioiodine treatment: what’s new. Cancers 14(15), (2022). https:\u002F\u002Fdoi.org\u002F10.3390\u002Fcancers14153800",{"id":21,"text":624,"url":21,"identifiers":21},"Y. Lin, T. Li, J. Liang et al. Predictive value of preablation stimulated thyroglobulin and thyroglobulin\u002Fthyroid-stimulating hormone ratio in differentiated thyroid cancer. Clin. Nucl. Med. 36(12), 1102–1105 (2011). https:\u002F\u002Fdoi.org\u002F10.1097\u002FRLU.0b013e3182291c65",{"id":21,"text":626,"url":21,"identifiers":21},"Y.W. Chang, H.S. Kim, S.P. Jung et al. Pre-ablation stimulated thyroglobulin is a better predictor of recurrence in pathological N1a papillary thyroid carcinoma than the lymph node ratio. Int J. Clin. Oncol. 21(5), 862–868 (2016). https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs10147-016-0956-2",{"id":21,"text":628,"url":21,"identifiers":21},"I.O. Amui, J.V. Tagliarini, E.C. Castilho et al. The first postoperative-stimulated serum thyroglobulin is a prognostic factor for thyroid microcarcinomas. Braz. J. Otorhinolaryngol. 85(1), 37–42 (2019). https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.bjorl.2017.10.005",{"id":21,"text":630,"url":21,"identifiers":21},"E. Karvounis, I. Kappas, A. Angelousi et al. The diagnostic and predictive accuracy of thyroglobulin to TSH ratio and TSH to thyroglobulin ratio in detecting differentiated thyroid carcinoma in normothyroid patients with thyroid nodules: a retrospective cohort study and systematic review of the literature. Oncol. Rev. 14(2), 439 (2020). https:\u002F\u002Fdoi.org\u002F10.4081\u002Foncol.2020.439",{"id":21,"text":632,"url":21,"identifiers":21},"Y. Ju, L. Wang, F. Cheng et al. Comparing the efficacy of thyroglobulin and thyroglobulin\u002F thyroid-stimulating hormone ratio models in predicting a successful response to radioactive iodine therapy. BMC Endocr. Disord. 23(1), 19 (2023). https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12902-022-01261-7",{"id":21,"text":634,"url":21,"identifiers":21},"C. Lu, C. Wang, F. Li et al. The influence of stimulated thyroglobulin and lymphocyte subsets before radioiodine therapy on the therapeutic response in patients with intermediate- and high-risk papillary thyroid carcinoma. Clin. Exp. Med. (2022). https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs10238-022-00932-y",{"id":21,"text":636,"url":21,"identifiers":21},"N. Dessoki, I. Nasr, A. Badawy et al. Value of the postablative thyroglobulin measurements for assessment of disease-free status in patients with differentiated thyroid cancer. Indian J. Nucl. Med. 34(2), 118–124 (2019). https:\u002F\u002Fdoi.org\u002F10.4103\u002Fijnm.IJNM_142_18",{"id":21,"text":638,"url":21,"identifiers":21},"R.M. Tuttle, H. Tala, J. Shah et al. Estimating risk of recurrence in differentiated thyroid cancer after total thyroidectomy and radioactive iodine remnant ablation: using response to therapy variables to modify the initial risk estimates predicted by the new American Thyroid Association staging system. Thyroid 20(12), 1341–1349 (2010). https:\u002F\u002Fdoi.org\u002F10.1089\u002Fthy.2010.0178",{"id":21,"text":640,"url":21,"identifiers":21},"A.E. Llamas-Olier, D.I. Cuéllar, G. Buitrago, Intermediate-risk papillary thyroid cancer: risk factors for early recurrence in patients with excellent response to initial therapy. Thyroid® 28(10), 1311–1317 (2018). https:\u002F\u002Fdoi.org\u002F10.1089\u002Fthy.2017.0578",{"id":21,"text":642,"url":21,"identifiers":21},"Y. Zhang, C. Zhang, Y. Ma et al. Prediction to the prognosis of children with neuroblastoma by nomogram based on the first-diagnosed inflammatory markers. Pediatr. Surg. Int. 39(1), 17 (2022). https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00383-022-05302-z",{"id":21,"text":644,"url":21,"identifiers":21},"R. Zhao, Z. Liang, K. Chen et al. Nomogram based on inflammatory biomarkers and nutritional indicators for predicting overall survival in locoregionally advanced nasopharyngeal carcinoma. J. Inflamm. Res. 15, 2971–2981 (2022). https:\u002F\u002Fdoi.org\u002F10.2147\u002Fjir.S366299",{"id":21,"text":646,"url":21,"identifiers":21},"Z. Zheng, R. Guan, Y. Zou et al. Nomogram based on inflammatory biomarkers to predict the recurrence of hepatocellular carcinoma-a multicentre experience. J. Inflamm. Res. 15, 5089–5102 (2022). https:\u002F\u002Fdoi.org\u002F10.2147\u002Fjir.S378099",{"id":21,"text":648,"url":21,"identifiers":21},"Y. Chen, C. Yu, D. Chen et al. A prognostic nomogram based on risk assessment for invasive micropapillary carcinoma of the breast after surgery. Cancer Med. 12(7), 8050–8062 (2023). https:\u002F\u002Fdoi.org\u002F10.1002\u002Fcam4.5595",{"id":21,"text":650,"url":21,"identifiers":21},"R. Wu, W. Liu, N. Li et al. Analysis of correlation factors influencing the outcome of initial 131I remnant ablative therapy in intermediate- to high-risk patients with papillary thyroid microcarcinoma. Nucl. Med Commun. 43(6), 669–674 (2022). https:\u002F\u002Fdoi.org\u002F10.1097\u002Fmnm.0000000000001554",{"id":21,"text":652,"url":21,"identifiers":21},"P.G. Trevizam, J.V. Tagliarini, E.C. Castilho et al. Thyroglobulin levels and thyroglobulin\u002Fthyrotropin ratio could predict the success of the ablative\u002Ftherapeutic (131)I in the differentiated thyroid cancers. Endocr. Res. 42(1), 42–48 (2017). https:\u002F\u002Fdoi.org\u002F10.3109\u002F07435800.2016.1173056",{"id":21,"text":654,"url":21,"identifiers":21},"Y. Li, M. Rao, C. Zheng et al. Analysis of factors influencing the clinical outcome after surgery and (131)I therapy in patients with moderate-risk thyroid papillary carcinoma. Front. Endocrinol. 13, 1015798 (2022). https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffendo.2022.1015798",{"id":21,"text":656,"url":21,"identifiers":21},"P. Yazici, M. Mihmanli, E. Bozkurt et al. Which is the best predictor of thyroid cancer: thyrotropin, thyroglobulin or their ratio? Hormones 15(2), 256–263 (2016). https:\u002F\u002Fdoi.org\u002F10.14310\u002Fhorm.2002.1677",{"id":21,"text":658,"url":21,"identifiers":21},"P. Trimboli, G. Treglia, L. Giovanella, Preoperative measurement of serum thyroglobulin to predict malignancy in thyroid nodules: a systematic review. Horm. Metab. Res. 47(4), 247–252 (2015). https:\u002F\u002Fdoi.org\u002F10.1055\u002Fs-0034-1395517",{"id":21,"text":660,"url":21,"identifiers":21},"N. Hulikal, A. Re, M. Banoth et al. Can preoperative serum thyroglobulin levels predict the risk of malignancy? Results from prospective analysis of biochemical predictors of malignancy in thyroid nodules. Acta Otorhinolaryngol. Ital. 40(1), 33–37 (2020). https:\u002F\u002Fdoi.org\u002F10.14639\u002F0392-100x-n0276",{"id":21,"text":662,"url":21,"identifiers":21},"H. Kim, S.Y. Park, J.H. Choe et al. Preoperative serum thyroglobulin and its correlation with the burden and extent of differentiated thyroid cancer. Cancers 12(3), (2020). https:\u002F\u002Fdoi.org\u002F10.3390\u002Fcancers12030625",{"id":21,"text":664,"url":21,"identifiers":21},"H. Wang, S. Zhao, C. Xu et al. Clinical value of ultrasonography and serum markers in preoperative N staging of thyroid cancer. Cells 11(22), (2022). https:\u002F\u002Fdoi.org\u002F10.3390\u002Fcells11223621",{"id":21,"text":666,"url":21,"identifiers":21},"Y. Feng, Y. Min, H. Chen et al. Construction and validation of a nomogram for predicting cervical lymph node metastasis in classic papillary thyroid carcinoma. J. Endocrinol. Invest. 44(10), 2203–2211 (2021). https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs40618-021-01524-5",{"id":21,"text":668,"url":21,"identifiers":21},"C.J. Cao, C.Y. Dou, J. Lian et al. Clinical outcomes and associated factors of radioiodine-131 treatment in differentiated thyroid cancer with cervical lymph node metastasis. Oncol. Lett. 15(5), 8141–8148 (2018). https:\u002F\u002Fdoi.org\u002F10.3892\u002Fol.2018.8270",{"id":21,"text":670,"url":21,"identifiers":21},"Y. Lu, L. Jiang, C. Chen et al. Clinicopathologic characteristics and outcomes of papillary thyroid carcinoma in younger patients. Medicine 99(15), e19795 (2020). https:\u002F\u002Fdoi.org\u002F10.1097\u002Fmd.0000000000019795",{"id":21,"text":672,"url":21,"identifiers":21},"F. Demir, F.S. Şimşek, T. Ansal Balcı, The role of pre-ablative stimulated thyroglobulin and thyroglobulin\u002Fthyroid-stimulating hormone ratio for predicting metastasis in thyroid cancer. Mol. Imaging Radionucl. Ther. 28(1), 21–26 (2019). https:\u002F\u002Fdoi.org\u002F10.4274\u002Fmirt.galenos.2018.09825",{"id":21,"text":674,"url":21,"identifiers":21},"H.J. Jiang, P.J. Hsiao, Clinical application of the ultrasound-guided fine needle aspiration for thyroglobulin measurement to diagnose lymph node metastasis from differentiated thyroid carcinoma-literature review. Kaohsiung J. Med Sci. 36(4), 236–243 (2020). https:\u002F\u002Fdoi.org\u002F10.1002\u002Fkjm2.12173",{"id":21,"text":676,"url":21,"identifiers":21},"C. Wang, H. Diao, P. Ren et al. Efficacy and affecting factors of (131)I thyroid remnant ablation after surgical treatment of differentiated thyroid carcinoma. Front. Oncol. 8, 640 (2018). https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffonc.2018.00640",{"id":21,"text":678,"url":21,"identifiers":21},"B. Barres, A. Kelly, F. Kwiatkowski et al. Stimulated thyroglobulin and thyroglobulin reduction index predict excellent response in differentiated thyroid cancers. J. Clin. Endocrinol. Metab. 104(8), 3462–3472 (2019). https:\u002F\u002Fdoi.org\u002F10.1210\u002Fjc.2018-02680",{"id":21,"text":680,"url":21,"identifiers":21},"W. Zheng, Z. Rui, X. Wang et al. The influences of TSH stimulation level, stimulated Tg level and Tg\u002FTSH ratio on the therapeutic effect of (131)I treatment in DTC patients. Front Endocrinol. 12, 601960 (2021). https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffendo.2021.601960",{"id":21,"text":682,"url":21,"identifiers":21},"S. Zubair Hussain, M.U. Zaman, S. Malik et al. Preablation stimulated thyroglobulin\u002FTSH ratio as a predictor of successful I(131)remnant ablation in patients with differentiated thyroid cancer following total thyroidectomy. J. Thyroid Res. 2014, 610273 (2014). https:\u002F\u002Fdoi.org\u002F10.1155\u002F2014\u002F610273",{"id":21,"text":684,"url":21,"identifiers":21},"S. Wu, H. Wang, Efficacy analysis of (131)I therapy and predictive value of preablation stimulated thyroglobulin for lung metastases from differentiated thyroid cancer. Ann. Endocrinol. 74(1), 40–44 (2013). https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ando.2012.11.007",{"id":21,"text":686,"url":21,"identifiers":21},"T. Zhao, J. Liang, T. Li et al. Serial stimulated thyroglobulin measurements are more specific for detecting distant metastatic differentiated thyroid cancer before radioiodine therapy. Chin. J. Cancer Res. 29(3), 213–222 (2017). https:\u002F\u002Fdoi.org\u002F10.21147\u002Fj.issn.1000-9604.2017.03.07",{"id":688,"createTime":689,"updateTime":690,"relativeEntities":691,"slug":692,"properties":693,"entityType":203,"verifyStatus":204,"verifyTime":703,"verifyNote":206,"languages":21,"translateLanguages":704,"viewCount":22,"primaryUrl":705,"fullTextUrl":21,"authors":706,"publicationType":296,"publisherRelationship":918,"citationCount":21,"citationInfo":21,"publishDate":970,"publishYear":971,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":972,"openAccess":21,"references":21,"isForceReanalyzing":350},"10179191-f60b-4b45-9bf8-d487af1d75e0","2023-12-15T04:34:15.495+00:00","2026-09-07T09:14:51.573+00:00",[],"Human-telomerase-reverse-transcriptase-in-papillary-thyroid-cancer-gene-expression-effects-of-silencing-and-regulation-by-BET-inhibitors-in-thyroid-cancer-cells",{"abstract":694,"title":696,"references":699,"doi":701},{"EN":695},"Mutations in TERT promoter have been detected in the more aggressive papillary thyroid cancers (PTCs). To elucidate the role of TERT as an eligible molecular target in these tumors, the expression of hTERT was analyzed in a series of PTCs and the effects of both pharmacological and RNA-interference-induced hTERT silencing were investigated in two human PTC cell lines (K1 and BCPAP). The expression levels of hTERT mRNA and protein were evaluated by real-time PCR and western blot assays, respectively. Effects of hTERT silencing on PTC cell lines were analyzed by MTT, migration and western blot assays. Pharmacological inhibition of hTERT was performed using two bromodomain and extra-terminal (BET) inhibitors, JQ1 and I-BET762. hTERT expression results increased in 20 out of 48 PTCs, including tumors either positive or negative for the presence of hTERT promoter and\u002For BRAF mutations. In K1 and BCPAP cells, hTERT silencing determined a reduction in cell viability (~50% for K1 and ~70%, for BCPAP, vs control) and migration properties that were associated with a decrease of AKT phosphorylation and β-Catenin expression. Moreover, hTERT mRNA levels were down-regulated by two BET inhibitors, JQ1 and I-BET762, which at the same dosage (0.5 and 5 µM) reduced the growth of these thyroid cancer cells. These findings demonstrate that hTERT may represent an excellent therapeutic target in subgroups of aggressive PTCs.",{"EN":697,"VI":698},"Human telomerase reverse transcriptase in papillary thyroid cancer: gene expression, effects of silencing and regulation by BET inhibitors in thyroid cancer cells","Men phiên mã ngược telomerase ở người trong ung thư tuyến giáp thể nhú: Biểu hiện gene, ảnh hưởng của làm câm gene và điều hòa bởi các chất ức chế BET trong tế bào ung thư tuyến giáp",{"VOID":700},"C.M. Kitahara, J.A. Sosa, The changing incidence of thyroid cancer. Nat. Rev. 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Wen, Efficacy and safety of vascular endothelial growth factor receptor tyrosine kinase inhibitors in the treatment of advanced thyroid cancer: a meta-analysis of randomized controlled trials. Onco Targets Ther. 9, 1167–1173 (2016)\nR. Leão, J.D. Apolónio, D. Lee, A. Figueiredo, U. Tabori, P. Castelo-Branco, Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer. J. Biomed. Sci. 25(1), 22 (2018)\nA. Pestana, J. Vinagre, M. Sobrinho-Simões, P. Soares, TERT biology and function in cancer: beyond immortalisation. J. Mol. Endocrinol. 58(2), R129–R146 (2017)\nA. Alzahrani, R. Alsaadi, A.K. Murugan, B.B. Sadiq, TERT promoter mutations in thyroid cancer. Horm. Cancer 7, 165–177 (2016)\nX. Liu, J. Bishop, Y. Shan, S. Pai, D. Liu, A.K. Murugan, H. Sun, A.K. El-Naggar, M. Xing, Highly prevalent TERT promoter mutations in aggressive thyroid cancers. Endocr. Rel. Cancer 20, 603–610 (2013)\nB. Xu, R. Ghossein, Genomic landscape of poorly differentiated and anaplastic thyroid carcinoma. Endocr. Pathol. 27, 205–212 (2016)\nR. Liu, M. Xing, TERT promoter mutations in thyroid cancer. Endocr. Rel. Cancer 23, R143–R155 (2016)\nH.G. Vuong, A.M. Altibi, U.N. Duong, H.T. Ngo, T.Q. Pham, H.M. Tran, N. Oishi, K. Mochizuki, T. Nakazawa, L. Hassell, R. Katoh, T. Kondo, Role of molecular markers to predict distant metastasis in papillary thyroid carcinoma: promising value of TERT promoter mutations and insignificant role of BRAF mutations—a meta-analysis. Tumour Biol. 39(10), 1010428317713913 (2017)\nG.C. Penna, A. Pestana, J.M. Cameselle, D. Momesso, F.A. de Andrade, A.P.A. Vidal, M.L. Araujo Junior, M. Melo, P.V. Fernandes, R. Corbo, M. Vaisman, M. Sobrinho-Simões, P. Soares et al. TERTp mutation is associated with a shorter progression free survival in patients with aggressive histology subtypes of follicular-cell derived thyroid carcinoma. Endocrine 61(3), 489–498 (2018)\nM. Muzza, C. Colombo, S. Rossi, D. Tosi, V. Cirello, M. Perrino, S. De Leo, E. Magnani, E. Pignatti, B. Vigo, M. Simoni, G. Bulfamante, L. Vicentini et al. Telomerase in differentiated thyroid cancer: promoter mutations, expression and localization. Mol. Cell. Endocrinol. 399, 288–295 (2015)\nV. Maggisano, M. Celano, S. Lepore, G.E. Lombardo, M. Sponziello, F. Rosignolo, A. Verrienti, F. Baldan, E. Puxeddu, C. Durante, S. Filetti, G. Damante, D. Russo et al. Silencing of hTERT blocks growth and migration of anaplastic thyroid cancer cells. Mol. Cell. Endocrinol. 448, 34–40 (2017)\nD. Cheng, Y. Zhao, S. Wang, F. Zhang, M. Russo, S.B. McMahon, J. Zhu, Repression of telomerase gene promoter requires human-specific genomic context and is mediated by multiple HDAC1-containing corepressor complexes. FASEB J. 31, 1165–1178 (2017)\nM. Celano, C. Mio, M. Sponziello, A. Verrienti, S. Bulotta, C. Durante, G. Damante, D. Russo, Targeting post-translational histone modifications for the treatment of non-medullary thyroid cancer. Mol. Cell. Endocrinol. 469, 38–47 (2018)\nX. Zhu, S.Y. Cheng, Epigenetic modifications: novel therapeutic approach for thyroid cancer. Endocrinol. Metab. 32, 326–331 (2017)\nC. Mio, E. Lavarone, F. Baldan, B. Toffoletto, C. Puppin, S. Filetti, C. Durante, D. Russo, A. Orlacchio, A. Di Cristofano, C. Di Loreto, G. Damante, MCM5 as a target of BET inhibitors in thyroid cancer cells. Endocr. Relat. Cancer 23(4), 335–347 (2016)\nX. Gao, X. Wu, X. Zhang, W. Hua, Y. Zhang, Y. Maimaiti, Z. Gao, Y. Zhang, Inhibition of BRD4 suppresses tumor growth and enhances iodine uptake in thyroid cancer. Biochem. Biophys. Res. Commun. 469(3), 679–685 (2016)\nM. Pérez-Salvia, M. Esteller, Bromodomain inhibitors and cancer therapy: from structures to applications. Epigenetics 12(5), 323–339 (2017)\nE. Wadhwa, T. Nicolaides, Bromodomain inhibitor review: bromodomain and extra-terminal family protein inhibitors as a potential new therapy in central nervous system tumors. Cureus 8(5), e620 (2016)\nS. Natarajan, Z. Chen, E.V. Wancewicz, B.P. Monia, D.R. Corey, Telomerase reverse transcriptase (hTERT) mRNA and telomerase RNA (hTR) as targets for downregulation of telomerase activity. Oligonucleotides 14, 263–273 (2004)\nW. Zhang, L. Xing, RNAi gene therapy of SiHa cells via targeting human TERT induces growth inhibition and enhances radiosensitivity. Int. J. Oncol. 43, 1228–1234 (2013)\nA.Q. Liu, L.Y. Ge, X. Lu, X.L. Luo, Y. Cai, X.Q. Ye, F.F. Geng, Silencing of the hTERT gene by shRNA inhibits colon cancer SW480 cell growth in vitro and in vivo. PLoS ONE 9, e107019 2014).\nP. Chen, W.L. Gu, M.Z. Gong, J. Wang, D.Q. Li, shRNA-mediated silencing of hTERT suppresses proliferation and promotes apoptosis in osteosarcoma cells. Cancer Gene Ther. 24, 325–332 (2017)\nL. Teng, M.C. Specht, C.B. Barden, T.J.Fahey III, Antisense hTERT inhibits thyroid cancer cell growth. J. Clin. Endocrinol. Metab. 88, 1362–1366 (2003).\nG.E. Lombardo, V. Maggisano, M. Celano, D. Cosco, C. Mignogna, F. Baldan, S.M. Lepore, L. Allegri, S. Moretti, C. Durante, G. Damante, M. Fresta, D. Russo et al. Anti-hTERT siRNA-loaded nanoparticles block the growth of anaplastic thyroid cancer xenograft. Mol. Cancer Ther. 17(6), 1187–1195 (2018)\nB.R. Haugen, E.K. Alexander, K.C. Bible, G. Doherty, S.J. Mandel, Y.E. Nikiforov, F. Pacini, G. Randolph, A. Sawka, M. Schlumberger, K.G. Schuff, S.I. Sherman, J.A. Sosa et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 26, 1–133 (2016)\nM. Celano, C. Mignogna, F. Rosignolo, M. Sponziello, M. Iannone, S.M. Lepore, G.E. Lombardo, V. Maggisano, A. Verrienti, S. Bulotta, C. Durante, C. Di Loreto, G. Damante et al. Expression of YAP1 in aggressive thyroid cancer. Endocrine 59, 209–212 (2018)\nM. Sponziello, F. Rosignolo, M. Celano, V. Maggisano, V. Pecce, R.F. De Rose, G.E. Lombardo, C. Durante, S. Filetti, G. Damante, D. Russo, S. Bulotta, Fibronectin-1 expression is increased in aggressive thyroid cancer and favors the migration and invasion of cancer cells. Mol. Cell. Endocrinol. 431, 123–132 (2016)\nR.E. Schweppe, J.P. Klopper, C. Korch, U. Puqazhenthi, M. Benezra, J.A. Knauf, J.A. Fagin, L.A. Marlow, J.A. Copland, R.C. Smallridge, B.R. Haugen, Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification. J. Clin. Endocrinol. Metab. 93(11), 4331–4341 (2008)\nM.J. Jeon, W.G. Kim, S. Sim, S. Lim, H. Kwon, T.Y. Kim, Y.K. Shong, W.B. Kim, Low prevalence of somatic TERT promoter mutations in classic papillary thyroid carcinoma. Endocrinol. Metab. 31, 100–104 (2016)\nM. D’Agostino, M. Sponziello, C. Puppin, M. Celano, V. Maggisano, F. Baldan, M. 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Rep. 39, 582–588 (2018)",{"VOID":702},"10.1007\u002Fs12020-018-01836-2","2025-01-15T16:47:09.266+00:00",[208],"http:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs12020-018-01836-2",[707,722,735,748,763,776,790,804,818,834,848,862,876,890,904],{"id":708,"sortIndex":22,"researcher":21,"roles":709,"affiliations":710,"properties":719,"displayName":721,"givenName":21,"familyName":21},"4053e36f-8456-424e-84a2-486edfd33b2b",[214],[711],{"id":712,"sortIndex":22,"affiliation":713,"properties":21},"d8ecab37-e430-4525-babd-3f94dbdd8af9",{"id":712,"createTime":21,"updateTime":21,"relativeEntities":714,"slug":21,"properties":715,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":718,"statistic":21},[],{"title":716},{"VI":717},"Department of Health Sciences, “Magna Graecia” University of Catanzaro, Catanzaro, Italy",[],{"title":720},{"VI":721},"Valentina Maggisano",{"id":723,"sortIndex":229,"researcher":21,"roles":724,"affiliations":725,"properties":732,"displayName":734,"givenName":21,"familyName":21},"67938649-1961-4846-9e22-3ba0ecd7c960",[214],[726],{"id":712,"sortIndex":22,"affiliation":727,"properties":21},{"id":712,"createTime":21,"updateTime":21,"relativeEntities":728,"slug":21,"properties":729,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":731,"statistic":21},[],{"title":730},{"VI":717},[],{"title":733},{"VI":734},"Marilena Celano",{"id":736,"sortIndex":245,"researcher":21,"roles":737,"affiliations":738,"properties":745,"displayName":747,"givenName":21,"familyName":21},"104d7e4b-bd85-486f-a430-84cfe9b07bbd",[214],[739],{"id":712,"sortIndex":22,"affiliation":740,"properties":21},{"id":712,"createTime":21,"updateTime":21,"relativeEntities":741,"slug":21,"properties":742,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":744,"statistic":21},[],{"title":743},{"VI":717},[],{"title":746},{"VI":747},"Saverio Massimo Lepore",{"id":749,"sortIndex":259,"researcher":21,"roles":750,"affiliations":751,"properties":760,"displayName":762,"givenName":21,"familyName":21},"aac71481-8156-4329-82bd-00050aab2d82",[214],[752],{"id":753,"sortIndex":22,"affiliation":754,"properties":21},"30d4fa69-68d9-4196-a591-f9f58761ae64",{"id":753,"createTime":21,"updateTime":21,"relativeEntities":755,"slug":21,"properties":756,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":759,"statistic":21},[],{"title":757},{"EN":758},"Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy",[],{"title":761},{"VI":762},"Marialuisa Sponziello",{"id":764,"sortIndex":275,"researcher":21,"roles":765,"affiliations":766,"properties":773,"displayName":775,"givenName":21,"familyName":21},"d7457655-e159-4852-a233-b3c76c7e753e",[214],[767],{"id":753,"sortIndex":22,"affiliation":768,"properties":21},{"id":753,"createTime":21,"updateTime":21,"relativeEntities":769,"slug":21,"properties":770,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":772,"statistic":21},[],{"title":771},{"EN":758},[],{"title":774},{"VI":775},"Francesca Rosignolo",{"id":777,"sortIndex":778,"researcher":21,"roles":779,"affiliations":780,"properties":787,"displayName":789,"givenName":21,"familyName":21},"5ae11266-eefb-4f2f-9493-1febc35daaa2",5,[214],[781],{"id":753,"sortIndex":22,"affiliation":782,"properties":21},{"id":753,"createTime":21,"updateTime":21,"relativeEntities":783,"slug":21,"properties":784,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":786,"statistic":21},[],{"title":785},{"EN":758},[],{"title":788},{"VI":789},"Valeria 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Proportional prevalence of goiter was greater for females than males 0.54 (95 % CI = 0.53–0.56) versus 0.46 (95 % CI = 0.44–0.47), these proportions for subgroups of longstanding iodine deficiency and recent (\u003C10 years) iodine sufficiency were 0.59 versus 0.41 and 0.54 versus 0.46, respectively; however, no gender difference was observed in proportional prevalence of goiter in the subgroup of longstanding (>10 years) iodine sufficiency (0.50 vs. 0.50). These proportions for grade 1 of goiter were 0.54 versus 0.46 and for grade 2 were 0.63 versus 0.37; for children were 0.54 versus 0.46 and for adults were 0.74 versus 0.26 for females and males, respectively. Subgroup analyses showed that there was an increasing trend in gender differences around the age of 15 years. Goiter is more frequent in females. 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Platvoet-Ter Schiphorst, A survey of iodine intake and thyroid volume in Dutch schoolchildren: reference values in an iodine-sufficient area and the effect of puberty. Eur. J. Endocrinol. 144, 595–603 (2001)",{"doi":1132},{"id":1128,"text":1155,"url":1130,"identifiers":1156},"S. Semiz, U. Senol, O. Bircan, S. Gümüslü, S. Akcurin, I. Bircan, Thyroid volume and urinary iodine excretion in children 6–11 years old in an endemic area. J. Pediatr. Endocrinol. Metab. 13, 245–251 (2000)",{"doi":1132},{"id":1128,"text":1158,"url":1130,"identifiers":1159},"C. Reiners, K. Wegscheider, H. Schicha, P. Theissen, R. Vaupel, R. Wrbitzky et al., Prevalence of thyroid disorders in the working population of Germany: ultrasonography screening in 96,278 unselected employees. Thyroid 14, 926–932 (2004)",{"doi":1132},{"id":1128,"text":1161,"url":1130,"identifiers":1162},"F. Delange, G. Benker, P. Caron, O. Eber, W. Ott, F. Peter et al., Thyroid volume and urinary iodine in European schoolchildren: standardization of values for assessment of iodine deficiency. Eur. J. Endocrinol. 136, 180–187 (1997)",{"doi":1132},{"id":1128,"text":1164,"url":1130,"identifiers":1165},"Y. Fleury, G. Van Melle, V. Woringer, R.C. Gaillard, L. Portmann, Sex-dependent variations and timing of thyroid growth during puberty. J. Clin. Endocrinol. Metab. 86, 750–754 (2001)",{"doi":1132},{"id":1128,"text":1167,"url":1130,"identifiers":1168},"F. Aghini-Lombardi, L. Antonangeli, A. Pinchera, F. Leoli, T. Rago, A.M. Bartolomei et al., Effect of iodized salt on thyroid volume of children living in an area previously characterized by moderate iodine deficiency. J. Clin. Endocrinol. Metab. 82, 1136–1139 (1997)",{"doi":1132},{"id":1128,"text":1170,"url":1130,"identifiers":1171},"M.F. Erdoğan, O. Demir, R. Emral, A.N. Kamel, G. 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Endocrinol. 148, 77–85 (1996)",{"doi":1132},{"id":1267,"createTime":1268,"updateTime":1269,"relativeEntities":1270,"slug":1271,"properties":1272,"entityType":203,"verifyStatus":204,"verifyTime":1283,"verifyNote":206,"languages":21,"translateLanguages":21,"viewCount":245,"primaryUrl":1284,"fullTextUrl":21,"authors":1285,"publicationType":296,"publisherRelationship":1374,"citationCount":22,"citationInfo":1426,"publishDate":1429,"publishYear":1427,"citationAnalyzeStatus":1124,"lastCitationAnalyze":1430,"indexDatabases":1431,"openAccess":21,"references":21,"isForceReanalyzing":350},"34c52967-8a8b-46e9-810e-255e90d34dda","2023-12-21T09:06:01.163+00:00","2026-08-16T19:58:53.270+00:00",[],"Assesment-of-oxidative-status-and-its-association-with-thyroid-autoantibodies-in-patients-with-euthyroid-autoimmune-thyroiditis",{"abstract":1273,"title":1275,"gsPaper":1277,"references":1279,"doi":1281},{"EN":1274},"Oxidative stress results from either overproduction of free radicals or insufficiency of several anti-oxidant defense systems. It leads to oxidation of main cellular macromolecules and a resultant molecular dysfunction. Thyroid hormones regulate oxidative metabolism and, thus, play a role in free radical production. Studies evaluating oxidative stress in patients with hypothyroidism and hyperthyroidism have been encountered in recent years; however, oxidative status in patients with euthyroid autoimmune thyroiditis (AIT) was not investigated previously. Thirty-five subjects with euthyroid AIT and 35 healthy controls were enrolled in the study. Serum oxidative status was determined by the measurement of total anti-oxidant status (TAS), total oxidant status (TOS), ischemia-modified albumin (IMA), and oxidized-low density lipoprotein (ox-LDL) levels. Serum TAS levels were significantly lower (p \u003C 0.001), while serum TOS levels and IMA levels were significantly higher (p \u003C 0.001 and p = 0.020, respectively) in patients compared to controls. In both groups, ox-LDL levels were similar (p = 0.608). Serum TAS levels were negatively correlated with anti-thyroid peroxidase and anti-thyroglobulin (anti-TG) levels (rho = −0.415, p = 0.001 and rho = −0.484, p \u003C 0.001, respectively). Serum TOS was positively correlated with anti-TG levels (rho = 0.547, p \u003C 0.001). Further, TAS was positively correlated with free T4 levels (r = 0.279, p = 0.043). No correlation was observed between thyrotropin, free T3 levels, and TOS and TAS levels. These results suggest that oxidants are increased, and anti-oxidants are decreased in patients with euthyroid AIT, and oxidative\u002Fanti-oxidative balance is shifted to the oxidative side. Increased oxidative stress might have a role in thyroid autoimmunity.",{"EN":1276},"Assesment of oxidative status and its association with thyroid autoantibodies in patients with euthyroid autoimmune thyroiditis",{"VOID":1278},"[\"6496723739690228550\"]",{"VOID":1280},"L. Oziol, P. Faure, N. Bertrand, P. 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