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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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10.1002\u002Fpath.1711680303",{"doi":1176},"10.1002\u002Fpath.1711680303",{"id":28,"text":1178,"url":28,"identifiers":1179},"Macchiarini, 1992, Relation of neovascularization to metastasis of non-small cell lung carcinoma., Lancet, 340, 145, 10.1016\u002F0140-6736(92)93217-B",{"doi":1180},"10.1016\u002F0140-6736(92)93217-B",{"id":28,"text":1182,"url":28,"identifiers":1183},"Bigler, 1993, Comparison of microscopic vascularity in benign and malignant prostate tissue., Hum Pathol, 24, 220, 10.1016\u002F0046-8177(93)90304-Y",{"doi":1184},"10.1016\u002F0046-8177(93)90304-Y",{"id":28,"text":1186,"url":28,"identifiers":1187},"Smith-McCune, 1994, Demonstration and characterization of the angiogenic properties of cervical dysplasia., Cancer Res, 54, 804",{},{"id":28,"text":1189,"url":28,"identifiers":1190},"Folkman, 1992, Angiogenesis., J Biol Chem, 267, 10931, 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10.1038\u002F380439a0",{"doi":1207},"10.1038\u002F380439a0",{"id":28,"text":1209,"url":28,"identifiers":1210},"Banai, 1994, Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs., Circulation, 89, 2183, 10.1161\u002F01.CIR.89.5.2183",{"doi":1211},"10.1161\u002F01.CIR.89.5.2183",{"id":28,"text":1213,"url":28,"identifiers":1214},"Harada, 1996, Vascular endothelial growth factor in chronic myocardial ischemia, Am J Physiol, 270, H1791",{},{"id":28,"text":1216,"url":28,"identifiers":1217},"Pearlman, 1995, Magnetic resonance mapping demonstrates benefits of VEGF-induced myocardial angiogenesis., Nature Med, 1, 1085, 10.1038\u002Fnm1095-1085",{"doi":1218},"10.1038\u002Fnm1095-1085",{"id":28,"text":1220,"url":28,"identifiers":1221},"Takeshita, 1994, Therapeutic angiogenesis: a single intra-arterial bolus of vascular endothelial growth factor augments collateral vessel formation in a rabbit ischemic hindlimb model., J Clin 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Mosby, St. Louis, MO, pp, 3",{},{"id":28,"text":1952,"url":28,"identifiers":1953},"Lopez, 1996, Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes., Invest Opthalmol Vis Sci, 37, 855",{},{"id":28,"text":1955,"url":28,"identifiers":1956},"Kvanta, 1996, Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor., Invest Ophthalmol Vis Sci, 37, 1929",{},{"id":28,"text":1958,"url":28,"identifiers":1959},"Kvanta, 1995, Expression and regulation of vascular endothelial growth factor in choroidal fibroblasts., Curr Eye Res, 14, 1015, 10.3109\u002F02713689508998523",{"doi":1960},"10.3109\u002F02713689508998523",{"id":28,"text":1962,"url":28,"identifiers":1963},"Koch, 1994, Vascular endothelial growth factor: a cytokine modulating endothelial function in rheumatoid arthritis., J Immunol, 152, 4149, 10.4049\u002Fjimmunol.152.8.4149",{"doi":1964},"10.4049\u002Fjimmunol.152.8.4149",{"id":28,"text":1966,"url":28,"identifiers":1967},"Fava, 1994, Vascular permeability factor\u002Fvascular endothelial growth factor (VPF\u002FVEGF): accumulation and expression in human synovial fluids and rheumatoid arthritis., J Exp Med, 180, 340, 10.1084\u002Fjem.180.1.341",{"doi":1968},"10.1084\u002Fjem.180.1.341",{"id":28,"text":1970,"url":28,"identifiers":1971},"Fassbender, 1983, The potential aggressiveness of synovial tissue in rheumatoid arthritis., J Pathol, 139, 399, 10.1002\u002Fpath.1711390314",{"doi":1972},"10.1002\u002Fpath.1711390314",{"id":28,"text":1974,"url":28,"identifiers":1975},"Hamilton, 1976, Hypothesis: in vitro evidence for the invasive and tumor-like properties of the rheumatoid pannus., J Rheumatol, 10, 845",{},{"id":28,"text":1977,"url":28,"identifiers":1978},"Brown, 1995, Increased expression of vascular permeability factor (vascular endothelial growth factor) in bullous pemphigoid, dermatitis herpetiformis and erythema multiforme., J Invest Dermatol, 104, 744, 10.1111\u002F1523-1747.ep12606974",{"doi":1979},"10.1111\u002F1523-1747.ep12606974",{"id":28,"text":1981,"url":28,"identifiers":1982},"Buttram Jr, 1979, Endometriosis., Curr Probl Obstet Gynecol, 11, 1",{},{"id":28,"text":1984,"url":28,"identifiers":1985},"McLaren, 1996, Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids., J Clin Invest, 98, 482, 10.1172\u002FJCI118815",{"doi":1986},"10.1172\u002FJCI118815",{"id":28,"text":1988,"url":28,"identifiers":1989},"Shifren, 1996, Ovarian steroid regulation of VEGF in human endometrium:implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis., J Clin Endocrinol Metab, 81, 3112",{},{"id":28,"text":1991,"url":28,"identifiers":1992},"Kamat, 1995, Expression of vascular permeability factor\u002Fvascular endothelial growth factor by human granulosa and theca lutein cells. Role in corpus luteum development., Am J Pathol, 146, 157",{},{"id":28,"text":1994,"url":28,"identifiers":1995},"Sato, 1995, Stimulation by thyroid- stimulating hormone and Grave’s immunoglobulin G of VEGF mRNA expression in human thyroid follicles in vitro and flt mRNA expression in the rat thyroid in vivo., J Clin Invest, 96, 1295, 10.1172\u002FJCI118164",{"doi":1996},"10.1172\u002FJCI118164",{"id":28,"text":1998,"url":28,"identifiers":1999},"Wartofsky, 1994, Diseases of the thyroid, In: Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS, Kasper DL (eds) Harrison’s Principles of Internal Medicine. McGraw Hill, New York, pp, 1930",{},{"id":28,"text":2001,"url":28,"identifiers":2002},"McClure, 1994, Vascular endothelial growth factor as capillary permeability agent in ovarian hyperstimulation syndrome., Lancet, 344, 235, 10.1016\u002FS0140-6736(94)93001-5",{"doi":2003},"10.1016\u002FS0140-6736(94)93001-5",{"id":28,"text":2005,"url":28,"identifiers":2006},"Baker, 1995, Elevated serum levels of vascular endothelial growth factor in patients with preeclampsia., Obstet Gynecol, 86, 815, 10.1016\u002F0029-7844(95)00259-T",{"doi":2007},"10.1016\u002F0029-7844(95)00259-T",{"id":28,"text":2009,"url":28,"identifiers":2010},"Thompson, 1990, Recruitment of growth and collateral circulation, In: Zelenock GB, D’Alecy LG, Fantone JC III, Shlafer M, Stanley JC Eds. Clinical ischemic syndromes: mechanisms and consequences of tissue injury. 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Mosby, St. Louis, MO, pp, 111",{},{"id":28,"text":2015,"url":28,"identifiers":2016},"Takeshita, 1996, Therapeutic angiogenesis following arterial gene transfer of vascular endothelial growth factor in a rabbit model of hindlimb ischemia., Biochem Biophys Res Commun, 227, 628, 10.1006\u002Fbbrc.1996.1556",{"doi":2017},"10.1006\u002Fbbrc.1996.1556",{"id":28,"text":2019,"url":28,"identifiers":2020},"Walder, 1996, Vascular endothelial growth factor improves blood flow and function in a chronic ischemic hind-limb model., J Cardiovasc Pharmacol, 27, 91, 10.1097\u002F00005344-199601000-00015",{"doi":2021},"10.1097\u002F00005344-199601000-00015",{"id":28,"text":2023,"url":28,"identifiers":2024},"Bauters, 1994, Physiologic assessment of augmented vascularity induced by VEGF in a rabbit ischemic hindlimb model, Am J Physiol, 267, H1263",{},{"id":28,"text":2026,"url":28,"identifiers":2027},"Sellke, 1992, Endothelial modulation of porcine coronary microcirculation perfused via immature vessels, Am J Physiol, 262, H1669",{},{"id":28,"text":2029,"url":28,"identifiers":2030},"Bauters, 1995, Recovery of disturbed endothelium-dependent flow in collateral-perfused rabbit ischemic hindlimb following administration of VEGF., Circulation, 91, 2793, 10.1161\u002F01.CIR.91.11.2802",{"doi":2031},"10.1161\u002F01.CIR.91.11.2802",{"id":28,"text":2033,"url":28,"identifiers":2034},"Essed, 1983, Transluminal coronary angioplasty and early restenosis., Br Heart J, 49, 393, 10.1136\u002Fhrt.49.4.393",{"doi":2035},"10.1136\u002Fhrt.49.4.393",{"id":28,"text":2037,"url":28,"identifiers":2038},"Asahara, 1995, Local delivery of vascular endothelial growth factor accelerates re-endothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery., Circulation, 91, 2802, 10.1161\u002F01.CIR.91.11.2793",{"doi":2039},"10.1161\u002F01.CIR.91.11.2793",{"id":28,"text":2041,"url":28,"identifiers":2042},"Callow, 1994, Vascular permeability factor accelerates endothelial regrowth following balloon angioplasty., Growth Factors, 10, 223, 10.3109\u002F08977199409000240",{"doi":2043},"10.3109\u002F08977199409000240",{"id":28,"text":2045,"url":28,"identifiers":2046},"Isner, 1996, Arterial gene transfer for therapeutic angiogenesis in patients with peripheral artery disease., Hum Gene Ther, 7, 859, 10.1089\u002Fhum.1996.7.8-959",{"doi":2047},"10.1089\u002Fhum.1996.7.8-959",{"id":28,"text":2049,"url":28,"identifiers":2050},"Rajewsky, 1996, Conditional gene targeting., J Clin Invest, 3, 600, 10.1172\u002FJCI118828",{"doi":2051},"10.1172\u002FJCI118828",{"id":28,"text":2053,"url":28,"identifiers":2054},"Dumont, 1993, The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors., Oncogene, 8, 1293",{},{"id":28,"text":2056,"url":28,"identifiers":2057},"Sato, 1995, Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation., Nature, 376, 70, 10.1038\u002F376070a0",{"doi":2058},"10.1038\u002F376070a0",{"id":28,"text":2060,"url":28,"identifiers":2061},"Friedlander, 1995, Definition of two angiogenic pathways by distinct alpha v integrins., Science, 270, 1500, 10.1126\u002Fscience.270.5241.1500",{"doi":2062},"10.1126\u002Fscience.270.5241.1500",{"id":28,"text":2064,"url":28,"identifiers":2065},"Mulhauser, 1995, VEGF165 expressed by a replication-deficient recombinant adenovirus vector induces angiogenesis in vivo., Circ Res, 77, 1077, 10.1161\u002F01.RES.77.6.1077",{"doi":2066},"10.1161\u002F01.RES.77.6.1077",{"id":28,"text":2068,"url":28,"identifiers":2069},"Strawn, 1996, Flk-1 as a target for tumor growth inhibition., Cancer Res, 56, 3540",{},{"id":28,"text":2071,"url":28,"identifiers":2072},"Robinson, 1996, Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy., Proc Natl Acad Sci USA, 93, 4851, 10.1073\u002Fpnas.93.10.4851",{"doi":2073},"10.1073\u002Fpnas.93.10.4851",false,{"id":2076,"createTime":2077,"updateTime":2077,"relativeEntities":2078,"slug":2079,"properties":2080,"entityType":1041,"verifyStatus":26,"verifyTime":2095,"verifyNote":1042,"languages":2096,"translateLanguages":28,"viewCount":32,"primaryUrl":2097,"fullTextUrl":28,"authors":2098,"publicationType":1080,"publisherRelationship":2249,"citationCount":2304,"citationInfo":2305,"publishDate":2318,"publishYear":2306,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":2319,"openAccess":28,"references":2320,"isForceReanalyzing":2074},"28c10cd1-842c-4468-a37a-b65d5362a6a1","2024-09-12T15:23:42.099+00:00",[],"Endocrine-Disrupting-Chemicals-An-Endocrine-Society-Scientific-Statement",{"mag":2081,"pmc":2083,"openalex":2085,"abstract":2087,"title":2089,"pm":2091,"doi":2093},{"VOID":2082},"2165700542",{"VOID":2084},"2726844",{"VOID":2086},"W2165700542",{"EN":2088},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>There is growing interest in the possible health threat posed by endocrine-disrupting chemicals (EDCs), which are substances in our environment, food, and consumer products that interfere with hormone biosynthesis, metabolism, or action resulting in a deviation from normal homeostatic control or reproduction. In this first Scientific Statement of The Endocrine Society, we present the evidence that endocrine disruptors have effects on male and female reproduction, breast development and cancer, prostate cancer, neuroendocrinology, thyroid, metabolism and obesity, and cardiovascular endocrinology. Results from animal models, human clinical observations, and epidemiological studies converge to implicate EDCs as a significant concern to public health. The mechanisms of EDCs involve divergent pathways including (but not limited to) estrogenic, antiandrogenic, thyroid, peroxisome proliferator-activated receptor γ, retinoid, and actions through other nuclear receptors; steroidogenic enzymes; neurotransmitter receptors and systems; and many other pathways that are highly conserved in wildlife and humans, and which can be modeled in laboratory in vitro and in vivo models. Furthermore, EDCs represent a broad class of molecules such as organochlorinated pesticides and industrial chemicals, plastics and plasticizers, fuels, and many other chemicals that are present in the environment or are in widespread use. We make a number of recommendations to increase understanding of effects of EDCs, including enhancing increased basic and clinical research, invoking the precautionary principle, and advocating involvement of individual and scientific society stakeholders in communicating and implementing changes in public policy and awareness.\u003C\u002Fjats:p>",{"EN":2090},"Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement",{"VOID":2092},"19502515",{"VOID":2094},"10.1210\u002Fer.2009-0002","2024-09-12T15:23:42.098+00:00",[31],"https:\u002F\u002Facademic.oup.com\u002Fedrv\u002Farticle\u002F30\u002F4\u002F293\u002F2355049",[2099,2118,2135,2154,2173,2192,2211,2230],{"id":2100,"sortIndex":32,"researcher":28,"roles":2101,"affiliations":2102,"properties":2111,"displayName":2115,"givenName":28,"familyName":28},"625fee44-cda2-41f8-9056-4db33b34d60e",[],[2103],{"id":2104,"sortIndex":32,"affiliation":2105,"properties":28},"55d05aaa-3c57-4cc5-bef9-ac131b86c36f",{"id":2104,"createTime":28,"updateTime":28,"relativeEntities":2106,"slug":28,"properties":2107,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2110,"statistic":28},[],{"title":2108},{"EN":2109},"Endocrine Section of First Department of Medicine (E.D.-K.), Laiko Hospital, Medical School University of Athens, 11527 Athens, Greece",[],{"orcid":2112,"title":2114,"openalex":2116},{"VOID":2113},"https:\u002F\u002Forcid.org\u002F0000-0003-2063-7319",{"EN":2115},"Evanthia Diamanti‐Kandarakis",{"VOID":2117},"A5086973330",{"id":2119,"sortIndex":40,"researcher":28,"roles":2120,"affiliations":2121,"properties":2130,"displayName":2132,"givenName":28,"familyName":28},"688b29e8-a588-46ea-b226-6bb253f94026",[],[2122],{"id":2123,"sortIndex":32,"affiliation":2124,"properties":28},"90fa8ebe-5f78-4126-93c7-44835c9d8064",{"id":2123,"createTime":28,"updateTime":28,"relativeEntities":2125,"slug":28,"properties":2126,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2129,"statistic":28},[],{"title":2127},{"EN":2128},"Department of Pediatrics (J.-P.B.), Centre Hospitalier Universitaire de Liege, 4000 Liege, Belgium",[],{"title":2131,"openalex":2133},{"EN":2132},"J P Bourguignon",{"VOID":2134},"A5087540372",{"id":2136,"sortIndex":123,"researcher":28,"roles":2137,"affiliations":2138,"properties":2147,"displayName":2151,"givenName":28,"familyName":28},"b2b284b1-bfcd-4da4-a25f-5c9228069de4",[],[2139],{"id":2140,"sortIndex":32,"affiliation":2141,"properties":28},"a7566a71-d96b-4360-be5f-056321a83f38",{"id":2140,"createTime":28,"updateTime":28,"relativeEntities":2142,"slug":28,"properties":2143,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2146,"statistic":28},[],{"title":2144},{"EN":2145},"Department of Obstetrics, Gynecology, and Reproductive Sciences (L.C.G.), University of California San Francisco, San Francisco, California 94131",[],{"orcid":2148,"title":2150,"openalex":2152},{"VOID":2149},"https:\u002F\u002Forcid.org\u002F0000-0002-1677-0822",{"EN":2151},"Linda C. Giudice",{"VOID":2153},"A5024724428",{"id":2155,"sortIndex":42,"researcher":28,"roles":2156,"affiliations":2157,"properties":2166,"displayName":2170,"givenName":28,"familyName":28},"b5194abb-79bf-4424-bfc2-eaae5609f5f6",[],[2158],{"id":2159,"sortIndex":32,"affiliation":2160,"properties":28},"fcd5e875-ec5d-40a6-bcf1-7f3214c7e058",{"id":2159,"createTime":28,"updateTime":28,"relativeEntities":2161,"slug":28,"properties":2162,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2165,"statistic":28},[],{"title":2163},{"EN":2164},"Department of Environmental Health (R.H.), Harvard School of Public Health, Boston, Massachusetts 02115",[],{"orcid":2167,"title":2169,"openalex":2171},{"VOID":2168},"https:\u002F\u002Forcid.org\u002F0000-0002-1899-3982",{"EN":2170},"Russ Hauser",{"VOID":2172},"A5017911709",{"id":2174,"sortIndex":45,"researcher":28,"roles":2175,"affiliations":2176,"properties":2185,"displayName":2189,"givenName":28,"familyName":28},"9991b8c9-ef86-4b24-b4d6-897ff36f087d",[],[2177],{"id":2178,"sortIndex":32,"affiliation":2179,"properties":28},"793f424f-8295-465a-b2c4-c0f44be691ea",{"id":2178,"createTime":28,"updateTime":28,"relativeEntities":2180,"slug":28,"properties":2181,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2184,"statistic":28},[],{"title":2182},{"EN":2183},"Department of Urology (G.S.P.), University of Illinois at Chicago, Chicago, Illinois 60612",[],{"orcid":2186,"title":2188,"openalex":2190},{"VOID":2187},"https:\u002F\u002Forcid.org\u002F0000-0002-9044-4734",{"EN":2189},"Gail S. 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10.1001\u002Fjama.300.11.1303",{"doi":4109},"10.1001\u002Fjama.300.11.1303",{"id":28,"text":4111,"url":28,"identifiers":4112},"Emmen, 2000, Involvement of insulin-like factor 3 (Insl3) in diethylstilbestrol-induced cryptorchidism., Endocrinology, 141, 846, 10.1210\u002Fendo.141.2.7379",{"doi":4113},"10.1210\u002Fendo.141.2.7379",{"id":28,"text":4115,"url":28,"identifiers":4116},"Ben Rhouma, 2001, Reproductive toxicity of DDT in adult male rats., Hum Exp Toxicol, 20, 393, 10.1191\u002F096032701682692946",{"doi":4117},"10.1191\u002F096032701682692946",{"id":28,"text":4119,"url":28,"identifiers":4120},"Fisher, 2003, Human testicular dysgenesis syndrome: a possible model using in-utero exposure of the rat to dibutyl phthalate., Hum Reprod, 18, 1383, 10.1093\u002Fhumrep\u002Fdeg273",{"doi":4121},"10.1093\u002Fhumrep\u002Fdeg273",{"id":28,"text":4123,"url":28,"identifiers":4124},"Parks, 2000, The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone 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10.1095\u002Fbiolreprod65.4.1271",{"doi":4137},"10.1095\u002Fbiolreprod65.4.1271",{"id":28,"text":4139,"url":28,"identifiers":4140},"Cohn, 2003, DDT and DDE exposure in mothers and time to pregnancy in daughters., Lancet, 361, 2205, 10.1016\u002FS0140-6736(03)13776-2",{"doi":4141},"10.1016\u002FS0140-6736(03)13776-2",{"id":28,"text":4143,"url":28,"identifiers":4144},"Markey, 2005, Long-term effects of fetal exposure to low doses of the xenoestrogen bisphenol-A in the female mouse genital tract., Biol Reprod, 72, 1344, 10.1095\u002Fbiolreprod.104.036301",{"doi":4145},"10.1095\u002Fbiolreprod.104.036301",{"id":28,"text":4147,"url":28,"identifiers":4148},"Howdeshell, 1999, Exposure to bisphenol A advances puberty., Nature, 401, 763, 10.1038\u002F44517",{"doi":4149},"10.1038\u002F44517",{"id":28,"text":4151,"url":28,"identifiers":4152},"Honma, 2002, Low dose effect of in utero exposure to bisphenol A and diethylstilbestrol on female mouse reproduction., Reprod Toxicol, 16, 117, 10.1016\u002FS0890-6238(02)00006-0",{"doi":4153},"10.1016\u002FS0890-6238(02)00006-0",{"id":28,"text":4155,"url":28,"identifiers":4156},"Zsarnovszky, 2005, Ontogeny of rapid estrogen-mediated extracellular signal-regulated kinase signaling in the rat cerebellar cortex: potent nongenomic agonist and endocrine disrupting activity of the xenoestrogen bisphenol A., Endocrinology, 146, 5388, 10.1210\u002Fen.2005-0565",{"doi":4157},"10.1210\u002Fen.2005-0565",{"id":28,"text":4159,"url":28,"identifiers":4160},"Steinberg, 2008, The effects of perinatal PCBs on adult female rat reproduction: development, reproductive physiology, and second generational effects., Biol Reprod, 78, 1091, 10.1095\u002Fbiolreprod.107.067249",{"doi":4161},"10.1095\u002Fbiolreprod.107.067249",{"id":28,"text":4163,"url":28,"identifiers":4164},"Jenkins, 2007, Prenatal TCDD exposure predisposes for mammary cancer in rats., Reprod Toxicol, 23, 391, 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A long-recognized but underappreciated pathological feature of type 2 diabetes., Diabetes, 48, 241, 10.2337\u002Fdiabetes.48.2.241",{"doi":7212},"10.2337\u002Fdiabetes.48.2.241",{"id":28,"text":7214,"url":28,"identifiers":7215},"Vigouroux, 1997, Genetic exclusion of 14 candidate genes in Lipoatropic diabetes using linkage analysis in 10 consanguineous families., J Clin Endocrinol Metab, 82, 3338",{},{"id":28,"text":7217,"url":28,"identifiers":7218},"Garg, 1999, A gene for congenital generalized lipodystrophy to human chromosome 9q34., J Clin Endocrinol Metab, 84, 3390, 10.1210\u002Fjcem.84.9.6103",{"doi":7219},"10.1210\u002Fjcem.84.9.6103",{"id":28,"text":7221,"url":28,"identifiers":7222},"Märin, Metabolism, 41, 882, 10.1016\u002F0026-0495(92)90171-6",{"doi":7223},"10.1016\u002F0026-0495(92)90171-6",{"id":28,"text":7225,"url":28,"identifiers":7226},"Bujalska, Lancet, 349, 1210, 10.1016\u002FS0140-6736(96)11222-8",{"doi":7227},"10.1016\u002FS0140-6736(96)11222-8",{"id":28,"text":7229,"url":28,"identifiers":7230},"Andrew, J Clin Endocrinol Metab, 83, 1806, 10.1210\u002Fjcem.83.5.4951",{"doi":7231},"10.1210\u002Fjcem.83.5.4951",{"id":28,"text":7233,"url":28,"identifiers":7234},"Pasquali, 1998",{},{"id":28,"text":7236,"url":28,"identifiers":7237},"Pasquali, J Clin Endocrinol Metab, 77, 341",{},{"id":28,"text":7239,"url":28,"identifiers":7240},"Moyer, Obes Res, 2, 255, 10.1002\u002Fj.1550-8528.1994.tb00055.x",{"doi":7241},"10.1002\u002Fj.1550-8528.1994.tb00055.x",{"id":28,"text":7243,"url":28,"identifiers":7244},"Pasquali, Metabolism, 45, 351, 10.1016\u002FS0026-0495(96)90290-5",{"doi":7245},"10.1016\u002FS0026-0495(96)90290-5",{"id":28,"text":7247,"url":28,"identifiers":7248},"Ljung, 1996, Inhibition of cortisol secretion by dexamethasone in relation to body fat distribution: a dose-response study., Obes Res, 4, 277, 10.1002\u002Fj.1550-8528.1996.tb00546.x",{"doi":7249},"10.1002\u002Fj.1550-8528.1996.tb00546.x",{"id":28,"text":7251,"url":28,"identifiers":7252},"Wajchenberg, Horm Res, 45, 99, 10.1159\u002F000184767",{"doi":7253},"10.1159\u002F000184767",{"id":28,"text":7255,"url":28,"identifiers":7256},"Seidell, Metabolism, 39, 897, 10.1016\u002F0026-0495(90)90297-P",{"doi":7257},"10.1016\u002F0026-0495(90)90297-P",{"id":28,"text":7259,"url":28,"identifiers":7260},"Haffner, 1993, Obesity, body fat distribution and sex hormones in men., Int J Obes, 17, 634",{},{"id":28,"text":7262,"url":28,"identifiers":7263},"Haffner, 1988, The relationship of sex hormones to hyperinsulinemia and hyperglycemia., Metabolism, 7, 638",{},{"id":28,"text":7265,"url":28,"identifiers":7266},"Copeland, 1990, The relationship between insulin-like growth factor 1, adiposity and aging., Metabolism, 39, 584, 10.1016\u002F0026-0495(90)90022-5",{"doi":7267},"10.1016\u002F0026-0495(90)90022-5",{"id":28,"text":7269,"url":28,"identifiers":7270},"Märin, 1992, The effects of testosterone treatment on body composition and metabolism in middle-aged obese men., Int J Obes, 16, 991",{},{"id":28,"text":7272,"url":28,"identifiers":7273},"Kley, 1981, Evidence of hypogonadism in massively obese males due to decreased free testosterone., Horm Metab Res, 13, 639, 10.1055\u002Fs-2007-1019359",{"doi":7274},"10.1055\u002Fs-2007-1019359",{"id":28,"text":7276,"url":28,"identifiers":7277},"Giagulli, 1994, Pathogenesis of the decreased androgen levels in obese men., J Clin Endocrinol Metab, 79, 997",{},{"id":28,"text":7279,"url":28,"identifiers":7280},"Leenen, 1994, Visceral fat accumulation in relation to sex hormones in obese men and women undergoing weight loss therapy., J Clin Endocrinol Metab, 78, 1515",{},{"id":28,"text":7282,"url":28,"identifiers":7283},"Rissanen, 1994, Visceral adiposity, androgens and plasma lipids in obese men., Metabolism, 43, 1318, 10.1016\u002F0026-0495(94)90229-1",{"doi":7284},"10.1016\u002F0026-0495(94)90229-1",{"id":28,"text":7286,"url":28,"identifiers":7287},"Smith, 1996, The endocrinology of obesity., Endocrinol Metab Clin North Am, 25, 921, 10.1016\u002FS0889-8529(05)70362-5",{"doi":7288},"10.1016\u002FS0889-8529(05)70362-5",{"id":28,"text":7290,"url":28,"identifiers":7291},"Vermeulen Kaufman, 1993, Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency and its relation to plasma androgens in hypogonadism of obese men., J Clin Endocrinol Metab, 76, 1140",{},{"id":28,"text":7293,"url":28,"identifiers":7294},"Gooren, 1989, Androgens and estrogens in their negative feedback action in the hypothalamo-pituitary-testis axis: site of action and evidence of their interaction., J Steroid Biochem, 33, 757, 10.1016\u002F0022-4731(89)90488-3",{"doi":7295},"10.1016\u002F0022-4731(89)90488-3",{"id":28,"text":7297,"url":28,"identifiers":7298},"Spijkstra, 1988, Divergent effects of the antiandrogen tamoxifen and of estrogens on luteinizing hormone(LH) pulse frequency, but not on basal LH levels and LH pulse amplitude in men., J Clin Endocrinol Metab, 66, 355, 10.1210\u002Fjcem-66-2-355",{"doi":7299},"10.1210\u002Fjcem-66-2-355",{"id":28,"text":7301,"url":28,"identifiers":7302},"Märin, 1993, Androgen treatment of abdominally obese men., Obes Res, 1, 245, 10.1002\u002Fj.1550-8528.1993.tb00618.x",{"doi":7303},"10.1002\u002Fj.1550-8528.1993.tb00618.x",{"id":28,"text":7305,"url":28,"identifiers":7306},"Yang, 1995, Additive effects of growth hormone and testosterone on lipolysis in adipocytes of hypophysectomized rats., J Endocrinol, 147, 147, 10.1677\u002Fjoe.0.1470147",{"doi":7307},"10.1677\u002Fjoe.0.1470147",{"id":28,"text":7309,"url":28,"identifiers":7310},"Märin, 1995, Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens., J Clin Endocrinol Metab, 80, 239",{},{"id":28,"text":6479,"url":28,"identifiers":7312},{},{"id":28,"text":7314,"url":28,"identifiers":7315},"Glass, 1989, Endocrine aspects of obesity., Med Clin North Am, 73, 139, 10.1016\u002FS0025-7125(16)30696-4",{"doi":7316},"10.1016\u002FS0025-7125(16)30696-4",{"id":28,"text":7318,"url":28,"identifiers":7319},"Veldhuis, 1991, Dual defects in pulsatile growth hormone secretion and clearence subserve the hyposomatotropism of obesity in man., J Clin Endocrinol Metab, 72, 51, 10.1210\u002Fjcem-72-1-51",{"doi":7320},"10.1210\u002Fjcem-72-1-51",{"id":28,"text":7322,"url":28,"identifiers":7323},"Rasmussen, 1995, Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-1 levels in obese subjects., J Clin Endocrinol Metab, 80, 1407",{},{"id":28,"text":7325,"url":28,"identifiers":7326},"Frystyk, 1995, 37",{},{"id":28,"text":7328,"url":28,"identifiers":7329},"Rasmussen, 1994, The impact of obesity, fat distribution and energy restriction on insulin-like growth factor-1 (IGF-1), IGF-binding protein-3, insulin and growth hormone., Metabolism, 43, 315, 10.1016\u002F0026-0495(94)90099-X",{"doi":7330},"10.1016\u002F0026-0495(94)90099-X",{"id":28,"text":7332,"url":28,"identifiers":7333},"Wabitsch, 1995, 45",{},{"id":28,"text":7335,"url":28,"identifiers":7336},"Brummer, 1993, Adipose tissue and muscle volume determination by computed tomography in Acromegaly before and 1 year after adenomectomy., Eur J Clin Invest, 23, 199, 10.1111\u002Fj.1365-2362.1993.tb00762.x",{"doi":7337},"10.1111\u002Fj.1365-2362.1993.tb00762.x",{"id":28,"text":7339,"url":28,"identifiers":7340},"Bengtsson, 1993, Treatment of adults with growth hormone deficiency with recombinant human growth., J Clin Endocrinol Metab, 76, 309",{},{"id":28,"text":7342,"url":28,"identifiers":7343},"Jorgensen, 1996, Growth hormone vs. placebo teatment for one year in growth hormone deficient adults: increase in exercise capacity and normalization of body composition., Clin Endocrinol (Oxf), 45, 681, 10.1046\u002Fj.1365-2265.1996.8720883.x",{"doi":7344},"10.1046\u002Fj.1365-2265.1996.8720883.x",{"id":28,"text":7346,"url":28,"identifiers":7347},"Beauville, 1992, Effect of long-term rhGH administration in GH-deficient adults on fat cell epinephrine response, Am J Physiol, 263, E467",{},{"id":28,"text":7349,"url":28,"identifiers":7350},"West, 1989, Regional changes in adipose tissue flow and metabolism in rats after a meal, Am J Physiol, 257, R711",{},{"id":28,"text":7352,"url":28,"identifiers":7353},"Rebuffé-Scrive, 1991, Neuroregulation of adipose tissue: molecular and hormonal mechanisms., Int J Obes, 15, 83",{},{"id":28,"text":7355,"url":28,"identifiers":7356},"Rebuffé-Scrive, 1989, Metabolism of mammary, abdominal and femoral adipocytes in women before and after menopause., Metabolism, 35, 792, 10.1016\u002F0026-0495(86)90217-9",{"doi":7357},"10.1016\u002F0026-0495(86)90217-9",{"id":28,"text":7359,"url":28,"identifiers":7360},"Rebuffé-Scrive, 1987, Regional adipose tissue metabolism in men and postmenopausal women., Int J Obes, 11, 347",{},{"id":28,"text":7362,"url":28,"identifiers":7363},"Metzger, 1994, Gonadal steroid hormone regulation of the somatotropic axis during puberty in humans. Mechanisms of androgen and estrogen action., Trends Endocrinol Metab, 5, 290, 10.1016\u002F1043-2760(94)P3204-K",{"doi":7364},"10.1016\u002F1043-2760(94)P3204-K",{"id":7366,"createTime":7367,"updateTime":7367,"relativeEntities":7368,"slug":7369,"properties":7370,"entityType":1041,"verifyStatus":26,"verifyTime":7367,"verifyNote":1042,"languages":7385,"translateLanguages":28,"viewCount":32,"primaryUrl":7386,"fullTextUrl":28,"authors":7387,"publicationType":1080,"publisherRelationship":7604,"citationCount":7659,"citationInfo":7660,"publishDate":7672,"publishYear":7661,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":7673,"openAccess":28,"references":7674,"isForceReanalyzing":2074},"1f8c8fb1-199b-4009-83f1-d431e1930db6","2024-09-20T16:03:07.835+00:00",[],"Hormones-and-Endocrine-Disrupting-Chemicals-Low-Dose-Effects-and-Nonmonotonic-Dose-Responses",{"mag":7371,"pmc":7373,"openalex":7375,"abstract":7377,"title":7379,"pm":7381,"doi":7383},{"VOID":7372},"2097327668",{"VOID":7374},"3365860",{"VOID":7376},"W2097327668",{"EN":7378},"\u003Cjats:p>For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional concepts in toxicology, in particular the dogma of “the dose makes the poison,” because EDCs can have effects at low doses that are not predicted by effects at higher doses. Here, we review two major concepts in EDC studies: low dose and nonmonotonicity. Low-dose effects were defined by the National Toxicology Program as those that occur in the range of human exposures or effects observed at doses below those used for traditional toxicological studies. We review the mechanistic data for low-dose effects and use a weight-of-evidence approach to analyze five examples from the EDC literature. Additionally, we explore nonmonotonic dose-response curves, defined as a nonlinear relationship between dose and effect where the slope of the curve changes sign somewhere within the range of doses examined. We provide a detailed discussion of the mechanisms responsible for generating these phenomena, plus hundreds of examples from the cell culture, animal, and epidemiology literature. We illustrate that nonmonotonic responses and low-dose effects are remarkably common in studies of natural hormones and EDCs. Whether low doses of EDCs influence certain human disorders is no longer conjecture, because epidemiological studies show that environmental exposures to EDCs are associated with human diseases and disabilities. We conclude that when nonmonotonic dose-response curves occur, the effects of low doses cannot be predicted by the effects observed at high doses. Thus, fundamental changes in chemical testing and safety determination are needed to protect human health.\u003C\u002Fjats:p>",{"EN":7380},"Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses",{"VOID":7382},"22419778",{"VOID":7384},"10.1210\u002Fer.2011-1050",[31],"https:\u002F\u002Facademic.oup.com\u002Fedrv\u002Farticle\u002F33\u002F3\u002F378\u002F2354852",[7388,7407,7424,7441,7460,7479,7498,7517,7533,7552,7569,7585],{"id":7389,"sortIndex":32,"researcher":28,"roles":7390,"affiliations":7391,"properties":7400,"displayName":7404,"givenName":28,"familyName":28},"f083a949-8f1b-4639-b213-47b865175299",[],[7392],{"id":7393,"sortIndex":32,"affiliation":7394,"properties":28},"2b1cc468-94b3-42ac-b217-c964352cae98",{"id":7393,"createTime":28,"updateTime":28,"relativeEntities":7395,"slug":28,"properties":7396,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":7399,"statistic":28},[],{"title":7397},{"EN":7398},"Center for Regenerative and Developmental Biology and Department of Biology (L.N.V.), Tufts University, Medford, Massachusetts 02155;",[],{"orcid":7401,"title":7403,"openalex":7405},{"VOID":7402},"https:\u002F\u002Forcid.org\u002F0000-0002-6807-9136",{"EN":7404},"Laura N. Vandenberg",{"VOID":7406},"A5032055617",{"id":7408,"sortIndex":40,"researcher":28,"roles":7409,"affiliations":7410,"properties":7419,"displayName":7421,"givenName":28,"familyName":28},"fd5179b4-1bb2-4d20-b22e-28cd0ef5dabf",[],[7411],{"id":7412,"sortIndex":32,"affiliation":7413,"properties":28},"8eac075f-78c0-4a80-881e-32a9fe76e220",{"id":7412,"createTime":28,"updateTime":28,"relativeEntities":7414,"slug":28,"properties":7415,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":7418,"statistic":28},[],{"title":7416},{"EN":7417},"The Endocrine Disruption Exchange (T.C.), Paonia, Colorado 81428;",[],{"title":7420,"openalex":7422},{"EN":7421},"Theo Colborn",{"VOID":7423},"A5031537044",{"id":7425,"sortIndex":123,"researcher":28,"roles":7426,"affiliations":7427,"properties":7436,"displayName":7438,"givenName":28,"familyName":28},"7098667f-8cac-4f41-9e11-4341502176b8",[],[7428],{"id":7429,"sortIndex":32,"affiliation":7430,"properties":28},"69ebcffa-b95b-443f-a58d-66a55c1a4f7f",{"id":7429,"createTime":28,"updateTime":28,"relativeEntities":7431,"slug":28,"properties":7432,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":7435,"statistic":28},[],{"title":7433},{"EN":7434},"Laboratory for Integrative Studies in Amphibian Biology (T.B.H.), Molecular Toxicology, Group in Endocrinology, Energy and Resources Group, Museum of Vertebrate Zoology, and Department of Integrative Biology, University of California, Berkeley, California 94720;",[],{"title":7437,"openalex":7439},{"EN":7438},"Thomas R. Hayes",{"VOID":7440},"A5032276483",{"id":7442,"sortIndex":42,"researcher":28,"roles":7443,"affiliations":7444,"properties":7453,"displayName":7457,"givenName":28,"familyName":28},"076d2c3b-1d20-4e91-84a6-ce47fcd77bb8",[],[7445],{"id":7446,"sortIndex":32,"affiliation":7447,"properties":28},"4ad4a348-77f6-46d0-a027-7842b3059949",{"id":7446,"createTime":28,"updateTime":28,"relativeEntities":7448,"slug":28,"properties":7449,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":7452,"statistic":28},[],{"title":7450},{"EN":7451},"Division of Extramural Research and Training (J.J.H.), National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina 27709;",[],{"orcid":7454,"title":7456,"openalex":7458},{"VOID":7455},"https:\u002F\u002Forcid.org\u002F0000-0002-0719-6523",{"EN":7457},"Jerrold J. 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10.1097\u002FEDE.0b013e3181df8e52",{"doi":10918},"10.1097\u002FEDE.0b013e3181df8e52",{"id":28,"text":10920,"url":28,"identifiers":10921},"Wirth, 2007, Ambient manganese exposure is negatively associated with human sperm motility and concentration, Epidemiology, 18, 270, 10.1097\u002F01.ede.0000253939.06166.7e",{"doi":10922},"10.1097\u002F01.ede.0000253939.06166.7e",{"id":28,"text":10924,"url":28,"identifiers":10925},"Lee, 2007, Relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among non-diabetic adults: results from the National Health and Nutrition Examination Survey 1999–2002, Diabetologia, 50, 1841, 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Recent evidence suggests that common stress-activated signaling pathways such as nuclear factor-κB, p38 MAPK, and NH2-terminal Jun kinases\u002Fstress-activated protein kinases underlie the development of these late diabetic complications. In addition, in type 2 diabetes, there is evidence that the activation of these same stress pathways by glucose and possibly FFA leads to both insulin resistance and impaired insulin secretion. Thus, we propose a unifying hypothesis whereby hyperglycemia and FFA-induced activation of the nuclear factor-κB, p38 MAPK, and NH2-terminal Jun kinases\u002Fstress-activated protein kinases stress pathways, along with the activation of the advanced glycosylation end-products\u002Freceptor for advanced glycosylation end-products, protein kinase C, and sorbitol stress pathways, plays a key role in causing late complications in type 1 and type 2 diabetes, along with insulin resistance and impaired insulin secretion in type 2 diabetes. 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1997, Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes., Diabetes Rev, 5, 177",{},{"id":28,"text":11839,"url":28,"identifiers":11840},"Reaven, 2000, 604",{},{"id":28,"text":11842,"url":28,"identifiers":11843},"Kahn, 1994, Insulin action, diabetogenes, and the cause of type II diabetes., Diabetes, 43, 1066, 10.2337\u002Fdiab.43.8.1066",{"doi":11844},"10.2337\u002Fdiab.43.8.1066",{"id":28,"text":11846,"url":28,"identifiers":11847},"Porte Jr, 2001, Clinical importance of insulin secretion and its interaction with insulin resistance in the treatment of type 2 diabetes mellitus and its complications., Diabetes Metab Res Rev, 17, 181, 10.1002\u002F1520-7560(200105\u002F06)17:3\u003C181::AID-DMRR197>3.0.CO;2-1",{"doi":11848},"10.1002\u002F1520-7560(200105\u002F06)17:3\u003C181::AID-DMRR197>3.0.CO;2-1",{"id":28,"text":11850,"url":28,"identifiers":11851},"Grodsky, 2000, 2",{},{"id":28,"text":11853,"url":28,"identifiers":11854},"Froguel, 2001, 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