[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_42c73b5e-6a39-409b-a766-0097d136e2ed":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:42c73b5e-6a39-409b-a766-0097d136e2ed,\"}":116},{"code":4,"data":5,"meta":24},"SUCCESS",{"id":6,"createTime":7,"updateTime":8,"relativeEntities":9,"slug":10,"properties":11,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":26,"manageAffiliations":51,"indexDatabases":73,"url":115,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},"42c73b5e-6a39-409b-a766-0097d136e2ed","2023-05-29T10:26:41.332+00:00","2025-11-21T10:02:54.451+00:00",[],"Cytometry-Part-A-the-journal-of-the-International-Society-for-Analytical-Cytology",{"country":12,"issn":14,"introduce":16,"eissn":18,"title":20},{"VOID":13},"US",{"VOID":15},"15524922",{"EN":17},"Cytometry Part A, the journal of quantitative single-cell analysis, features original research reports and reviews of innovative scientific studies employing quantitative single-cell measurement, separation, manipulation, and modeling techniques, as well as original articles on mechanisms of molecular and cellular functions obtained by cytometry techniques. The journal welcomes submissions from multiple research fields that fully embrace the study of the cytome: Biomedical Instrumentation Engineering Biophotonics Bioinformatics Cell Biology Computational Biology Data Science Immunology Parasitology Microbiology Neuroscience Cancer Stem Cells Tissue Regeneration.",{"VOID":19},"15524930",{"EN":21},"Cytometry. Part A : the journal of the International Society for Analytical Cytology","PUBLISHER","PENDING",null,0,[27,35,43],{"id":28,"createTime":29,"updateTime":30,"relativeEntities":31,"label":32,"description":34,"parentId":24,"standard":24,"scholarHubFieldId":24},"43fa52e2-3f93-4221-b984-b642751ae825","2023-05-29T10:24:32.319+00:00","2023-11-21T07:50:36.379+00:00",[],{"EN":33},"Histology",{},{"id":36,"createTime":37,"updateTime":38,"relativeEntities":39,"label":40,"description":42,"parentId":24,"standard":24,"scholarHubFieldId":24},"1e162c3b-d9db-4fe2-ae4f-d5f2251c2ce9","2023-05-29T10:25:00.590+00:00","2023-11-21T06:45:59.208+00:00",[],{"EN":41},"Pathology and Forensic Medicine",{},{"id":44,"createTime":45,"updateTime":46,"relativeEntities":47,"label":48,"description":50,"parentId":24,"standard":24,"scholarHubFieldId":24},"131e254e-0b02-478f-aa3e-0b27d8c7b9d1","2023-05-29T10:24:28.895+00:00","2023-11-21T07:54:54.939+00:00",[],{"EN":49},"Cell Biology",{},[52,63],{"id":53,"createTime":54,"updateTime":55,"relativeEntities":56,"slug":57,"properties":58,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"url":24,"parentIds":62,"statistic":24},"dbab0d8b-1eeb-49c8-86e2-223cba83a1b2","2023-05-29T10:25:19.582+00:00","2025-11-21T10:03:42.573+00:00",[],"Wiley-Liss-Inc-",{"title":59},{"EN":60},"Wiley-Liss Inc.","AFFILIATION",[],{"id":64,"createTime":65,"updateTime":66,"relativeEntities":67,"slug":68,"properties":69,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":71,"url":24,"parentIds":72,"statistic":24},"43d4a537-d044-4372-8544-ca45c3bea38f","2023-05-29T12:06:07.474+00:00","2024-02-13T10:28:57.921+00:00",[],"WILEY",{"title":70},{"EN":68},6,[],[74,95],{"id":75,"indexDatabase":76,"url":88,"indexYears":89,"academicFieldIds":90,"indexDatabaseRanking":94},"b0d79e50-cf37-4cdf-a015-31bf3f4d3f77",{"id":77,"createTime":78,"updateTime":79,"relativeEntities":80,"label":81,"description":83,"key":85,"publicationTags":86,"standard":24},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9","2023-05-22T09:57:18.509+00:00","2025-11-21T10:07:52.274+00:00",[],{"EN":82,"VI":82},"Scopus - Elsevier",{"EN":82,"VI":84},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[87],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F18517","2003-2025",[91,92,93],"3ae494ca-72b1-4f7f-a18c-56c79894839d","5d0ba0cd-b333-4796-a92a-6418d1621f5b","d2139bd1-2fdb-481b-a416-9c30dd0cc173","SCOPUS__Q1",{"id":96,"indexDatabase":97,"url":111,"indexYears":24,"academicFieldIds":112,"indexDatabaseRanking":24},"90f7efc8-bc1f-48af-854d-67ede1c17c9b",{"id":98,"createTime":99,"updateTime":100,"relativeEntities":101,"label":102,"description":104,"key":107,"publicationTags":108,"standard":24},"a4921856-b128-4d9f-8f1f-e80813d3bbd4","2023-05-22T09:59:31.026+00:00","2025-11-21T10:07:52.153+00:00",[],{"EN":103,"VI":103},"ISI\u002FSCIE - Science Citation Index Expanded",{"VI":105,"EN":106},"Cơ sở dữ liệu SCIE","SCIE database","scie",[109,110],"SCIE","ISI","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=1552-4922",[113,114],"cce3975f-7334-4658-9bbf-df0ab44312e1","8eb75d88-0c7a-497c-a346-e729afc75040","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fjournal\u002F15524930",{"meta":117,"data":119},{"total":118},"26",[120,279,595,856,1120,1440,1786,1907,2184,2438],{"id":121,"createTime":122,"updateTime":122,"relativeEntities":123,"slug":124,"properties":125,"entityType":139,"verifyStatus":140,"verifyTime":122,"verifyNote":141,"syncStatus":23,"languages":142,"translateLanguages":24,"viewCount":25,"primaryUrl":144,"fullTextUrl":24,"authors":145,"publicationType":184,"publisherRelationship":185,"citationCount":218,"citationInfo":219,"publishDate":221,"publishYear":222,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":223,"isForceReanalyzing":278},"01be7508-335d-414e-8dd2-6ba79cc1ed79","2024-10-14T23:48:14.369+00:00",[],"Modification-to-the-Lampariello-approach-to-evaluate-reactive-oxygen-species-production-by-flow-cytometry",{"mag":126,"keywords":128,"openalex":129,"abstract":131,"title":133,"pm":135,"doi":137},{"VOID":127},"2091661665",{},{"VOID":130},"W2091661665",{"EN":132},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>The aim of this article is to perform a statistical analysis of reactive oxygen species (ROS) cytometric data. It is demonstrated that the classical parametric and nonparametric statistical tests are not suitable to examine these data; the Kolmogorov‐Smirnov test and the modification proposed by Lampariello are shown to be too sensitive with respect to the experimental bias (due to procedure or to the instrument) and variability in the ROS production within the repeated samples. Several approaches are examined and discussed. Modifications of the Lampariello's procedure are proposed to include the variability within samples. The validity of the proposed approach is verified by analyzing repeated measurements of ROS formation in cultured human lymphocytes untreated or treated with ferrous sulfate. The proposed approach is successful in considering the “intersample” variability in the ROS data analysis and keeps a good level of validity. Nevertheless, this procedure is not user‐friendly and needs to be handled by an expert operator. © 2007 International Society for Analytical Cytology\u003C\u002Fjats:p>",{"EN":134},"Modification to the Lampariello approach to evaluate reactive oxygen species production by flow cytometry",{"VOID":136},"18163463",{"VOID":138},"10.1002\u002Fcyto.a.20508","PUBLICATION","VERIFIED","Auto Verify",[143],"EN","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcyto.a.20508",[146,169],{"id":147,"sortIndex":148,"researcher":24,"roles":149,"affiliations":150,"properties":162},"0721a6ec-06b3-46da-9e74-e6be5e4845f9",1,[],[151],{"id":152,"sortIndex":25,"affiliation":153,"properties":24},"decfc4fc-cccc-48d1-9d89-3ae77476bc59",{"id":154,"createTime":155,"updateTime":156,"relativeEntities":157,"slug":158,"properties":159,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"0be10f41-a815-4c44-b253-e7f65c7e98b7","2024-10-14T23:48:14.386+00:00","2025-06-12T00:43:48.659+00:00",[],"CNR-Institute-for-Electromagnetic-Sensing-of-Environment-IREA-Naples-Italy",{"title":160},{"EN":161},"CNR‐Institute for Electromagnetic Sensing of Environment (IREA), Naples, Italy",{"openalex":163,"orcid":165,"title":167},{"VOID":164},"A5053067932",{"VOID":166},"https:\u002F\u002Forcid.org\u002F0000-0002-5063-4154",{"EN":168},"Maurizio Sarti",{"id":170,"sortIndex":25,"researcher":24,"roles":171,"affiliations":172,"properties":179},"ec645be9-b339-4dda-a077-3e7de85ee8c6",[],[173],{"id":174,"sortIndex":25,"affiliation":175,"properties":24},"358a6fed-6c17-4a32-8bce-d30610308e3c",{"id":154,"createTime":155,"updateTime":156,"relativeEntities":176,"slug":158,"properties":177,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":178},{"EN":161},{"openalex":180,"title":182},{"VOID":181},"A5041895405",{"EN":183},"F. Brescia","ARTICLE",{"url":24,"publisher":186,"properties":211},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":187,"slug":10,"properties":188,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":194,"manageAffiliations":195,"indexDatabases":196,"url":115,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":189,"issn":190,"introduce":191,"eissn":192,"title":193},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[197,204],{"id":96,"indexDatabase":198,"url":111,"indexYears":24,"academicFieldIds":203,"indexDatabaseRanking":24},{"id":98,"createTime":99,"updateTime":100,"relativeEntities":199,"label":200,"description":201,"key":107,"publicationTags":202,"standard":24},[],{"EN":103,"VI":103},{"VI":105,"EN":106},[109,110],[113,114],{"id":75,"indexDatabase":205,"url":88,"indexYears":89,"academicFieldIds":210,"indexDatabaseRanking":94},{"id":77,"createTime":78,"updateTime":79,"relativeEntities":206,"label":207,"description":208,"key":85,"publicationTags":209,"standard":24},[],{"EN":82,"VI":82},{"EN":82,"VI":84},[87],[91,92,93],{"volume":212,"pages":214,"issue":216},{"VOID":213},"73A",{"VOID":215},"175-179",{"VOID":217},"2",8,{"total":218,"publishYear":24,"statisticByYear":220},{"2012":148,"2021":148,"2022":148},"2008-02-01",2008,[224,227,230,233,236,239,242,245,248,251,254,257,260,263,266,269,272,275],{"id":24,"text":225,"url":24,"identifiers":226},"10.1088\u002F0967-3334\u002F26\u002F3\u002FR02",{"doi":225},{"id":24,"text":228,"url":24,"identifiers":229},"10.1016\u002Fj.femsec.2004.01.014",{"doi":228},{"id":24,"text":231,"url":24,"identifiers":232},"Hahn GJ, 1967, Statistical Models in Engineering",{},{"id":24,"text":234,"url":24,"identifiers":235},"10.1177\u002F25.7.894009",{"doi":234},{"id":24,"text":237,"url":24,"identifiers":238},"Press WH, 2007, Numerical Recipes: The Art of Scientific Computing",{},{"id":24,"text":240,"url":24,"identifiers":241},"10.1002\u002F(SICI)1097-0320(20000301)39:3\u003C179::AID-CYTO2>3.0.CO;2-I",{"doi":240},{"id":24,"text":243,"url":24,"identifiers":244},"Eaton JW, 2002, Gnu Octave Manual",{},{"id":24,"text":246,"url":24,"identifiers":247},"10.1021\u002Far50088a003",{"doi":246},{"id":24,"text":249,"url":24,"identifiers":250},"10.1046\u002Fj.1471-4159.2003.01708.x",{"doi":249},{"id":24,"text":252,"url":24,"identifiers":253},"10.1016\u002FS0197-0186(00)00053-X",{"doi":252},{"id":24,"text":255,"url":24,"identifiers":256},"10.1038\u002Fsj.bjp.0705776",{"doi":255},{"id":24,"text":258,"url":24,"identifiers":259},"10.2307\u002F1403192",{"doi":258},{"id":24,"text":261,"url":24,"identifiers":262},"Vysochanskij DF, 1980, Justification of the 3s rule for unimodal distributions, Theor Probab Math Stat, 21, 25",{},{"id":24,"text":264,"url":24,"identifiers":265},"10.1016\u002FS0955-0674(03)00002-4",{"doi":264},{"id":24,"text":267,"url":24,"identifiers":268},"10.1016\u002FS0009-9120(99)00075-2",{"doi":267},{"id":24,"text":270,"url":24,"identifiers":271},"10.1016\u002FS1369-5274(99)80033-2",{"doi":270},{"id":24,"text":273,"url":24,"identifiers":274},"10.1152\u002Fajplung.00466.2001",{"doi":273},{"id":24,"text":276,"url":24,"identifiers":277},"10.1002\u002Fcyto.b.20082",{"doi":276},false,{"id":280,"createTime":281,"updateTime":282,"relativeEntities":283,"slug":284,"properties":285,"entityType":139,"verifyStatus":140,"verifyTime":281,"verifyNote":141,"syncStatus":23,"languages":302,"translateLanguages":303,"viewCount":25,"primaryUrl":305,"fullTextUrl":24,"authors":306,"publicationType":184,"publisherRelationship":478,"citationCount":511,"citationInfo":512,"publishDate":520,"publishYear":521,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":522,"isForceReanalyzing":278},"91804f59-5a5d-4cb8-a82c-9b3f434eff99","2024-10-05T13:53:55.475+00:00","2025-02-03T18:55:24.986+00:00",[],"Refractive-index-measurement-in-viable-cells-using-quantitative-phase-amplitude-microscopy-and-confocal-microscopy",{"mag":286,"keywords":288,"openalex":290,"abstract":292,"title":295,"pm":298,"doi":300},{"VOID":287},"2001198450",{"VI":289},"",{"VOID":291},"W2001198450",{"VI":293,"EN":294},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Nền tảng\u003C\u002Fjats:title>\u003Cjats:p>Chỉ số khúc xạ (RI) của vật liệu tế bào cung cấp thông tin sinh lý học cơ bản về thành phần và cấu trúc tổ chức của tế bào. Những nỗ lực mô tả tính chất khúc xạ của tế bào đã bị cản trở đáng kể bởi những khó khăn thực nghiệm trong việc đo chỉ số khúc xạ của tế bào sống. Trong báo cáo này, chúng tôi mô tả một thủ tục ứng dụng kính hiển vi pha định lượng kết hợp với kính hiển vi huỳnh quang để đo chỉ số khúc xạ của một mẫu tế bào cơ nuôi cấy.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Phương pháp\u003C\u002Fjats:title>\u003Cjats:p>Chiến lược thí nghiệm bao gồm việc tính toán độ dày của tế bào bằng cách sử dụng quy trình cắt lớp quang học huỳnh quang, xây dựng bản đồ pha của cùng một tế bào bằng kính hiển vi pha định lượng, và lựa chọn các vùng tế bào quan tâm để giải quyết chỉ số khúc xạ tế bào.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Kết quả\u003C\u002Fjats:title>\u003Cjats:p>Giá trị độ dày trung bình của tế bào và giá trị pha cho sáu vùng tế bào (năm vùng tế bào chất và một vùng nhân) đã được xác định. Giá trị chỉ số khúc xạ trung bình tính toán cho các vùng tế bào chất và nhân là 1.360 ± 0.004. Sự không chắc chắn trong giá trị chỉ số khúc xạ cuối cùng đại diện cho sai số đo lường kỹ thuật.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Kết luận\u003C\u002Fjats:title>\u003Cjats:p>Phương pháp mà chúng tôi mô tả để đo chỉ số khúc xạ của tế bào sống với mẫu tế bào nguyên mẫu này có ứng dụng rộng rãi trong nghiên cứu sự phát triển và phản ứng chức năng của tế bào. Giá trị chỉ số khúc xạ mà chúng tôi báo cáo có thể được sử dụng trong phân tích quang học cấu trúc và hình thái tế bào nuôi cấy. © 2005 Wiley‐Liss, Inc.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Background\u003C\u002Fjats:title>\u003Cjats:p>The refractive index (RI) of cellular material provides fundamental biophysical information about the composition and organizational structure of cells. Efforts to describe the refractive properties of cells have been significantly impeded by the experimental difficulties encountered in measuring viable cell RI. In this report we describe a procedure for the application of quantitative phase microscopy in conjunction with confocal microscopy to measure the RI of a cultured muscle cell specimen.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>The experimental strategy involved calculation of cell thickness by using confocal optical sectioning procedures, construction of a phase map of the same cell using quantitative phase microscopy, and selection of cellular regions of interest to solve for the cell RI.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Mean cell thickness and phase values for six cell regions (five cytoplasmic and one nuclear) were determined. The average refractive index calculated for cytoplasmic and nuclear regions was 1.360 ± 0.004. The uncertainty in the final RI value represents the technique measurement error.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>The methodology we describe for viable cell RI measurement with this prototype cell has broad generic application in the study of cell growth and functional responses. The RI value we report may be used in optical analyses of cultured cell structure and morphology. © 2005 Wiley‐Liss, Inc.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"VI":296,"EN":297},"Đo chỉ số khúc xạ trong các tế bào sống bằng kính hiển vi pha-độ lớn định lượng và kính hiển vi huỳnh quang","Refractive index measurement in viable cells using quantitative phase‐amplitude microscopy and confocal microscopy",{"VOID":299},"15800856",{"VOID":301},"10.1002\u002Fcyto.a.20134",[143],[304],"VI","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcyto.a.20134",[307,328,350,370,388,406,426,444,461],{"id":308,"sortIndex":309,"researcher":24,"roles":310,"affiliations":311,"properties":323},"6603b5d2-e1a1-4ffb-9e6e-27331302120e",2,[],[312],{"id":313,"sortIndex":25,"affiliation":314,"properties":24},"11679f38-0d5b-4b58-b170-b3d19c7674c2",{"id":315,"createTime":316,"updateTime":317,"relativeEntities":318,"slug":319,"properties":320,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"83487955-854f-4459-95e3-70cdf31302bb","2024-02-06T15:40:26.665+00:00","2024-10-05T13:53:55.512+00:00",[],"Department-of-Pharmacology-University-of-Melbourne-Parkville-Victoria-Australia",{"title":321},{"VI":322},"Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia",{"openalex":324,"title":326},{"VOID":325},"A5056257929",{"EN":327},"Trudi Harris",{"id":329,"sortIndex":218,"researcher":24,"roles":330,"affiliations":331,"properties":343},"effa3c65-c554-49bb-8c2c-175605edd48b",[],[332],{"id":333,"sortIndex":25,"affiliation":334,"properties":24},"8a6e5414-f3b0-4ef3-a37f-67d6a1b985c6",{"id":335,"createTime":336,"updateTime":337,"relativeEntities":338,"slug":339,"properties":340,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"7ea2ab1a-48f3-458a-bdd5-00c830e6f481","2024-01-10T07:58:44.744+00:00","2024-12-10T13:24:30.999+00:00",[],"Department-of-Physiology-University-of-Melbourne-Parkville-Victoria-Australia",{"title":341},{"VI":342},"Department of Physiology, University of Melbourne, Parkville, Victoria, Australia",{"openalex":344,"orcid":346,"title":348},{"VOID":345},"A5012918166",{"VOID":347},"https:\u002F\u002Forcid.org\u002F0000-0003-1859-0152",{"EN":349},"Lea M.D. Delbridge",{"id":351,"sortIndex":148,"researcher":24,"roles":352,"affiliations":353,"properties":365},"9943f629-df39-497e-8046-241acb1fff47",[],[354],{"id":355,"sortIndex":25,"affiliation":356,"properties":24},"529ba62d-8d17-4f45-ae55-30872859ce7e",{"id":357,"createTime":358,"updateTime":359,"relativeEntities":360,"slug":361,"properties":362,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"0aca9161-b379-4472-847c-61ab9e5a4c91","2023-11-25T23:35:39.194+00:00","2025-06-11T23:41:08.631+00:00",[],"School-of-Physics-University-of-Melbourne-Parkville-Victoria-Australia",{"title":363},{"VI":364},"School of Physics, University of Melbourne, Parkville, Victoria, Australia",{"openalex":366,"title":368},{"VOID":367},"A5017510929",{"EN":369},"Catherine J. Bellair",{"id":371,"sortIndex":372,"researcher":24,"roles":373,"affiliations":374,"properties":381},"443879a4-ad7f-4c02-80a9-27379de4f148",7,[],[375],{"id":376,"sortIndex":25,"affiliation":377,"properties":24},"7bfadcf5-2efd-4731-8965-e6d3688c167e",{"id":357,"createTime":358,"updateTime":359,"relativeEntities":378,"slug":361,"properties":379,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":380},{"VI":364},{"openalex":382,"orcid":384,"title":386},{"VOID":383},"A5033000618",{"VOID":385},"https:\u002F\u002Forcid.org\u002F0000-0002-4281-3478",{"EN":387},"K. Nugent",{"id":389,"sortIndex":390,"researcher":24,"roles":391,"affiliations":392,"properties":399},"a7223cbf-aff1-43c1-98a3-ff868235da3b",4,[],[393],{"id":394,"sortIndex":25,"affiliation":395,"properties":24},"b1e1b3b5-9395-4462-9003-143165c8ceda",{"id":335,"createTime":336,"updateTime":337,"relativeEntities":396,"slug":339,"properties":397,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":398},{"VI":342},{"openalex":400,"orcid":402,"title":404},{"VOID":401},"A5052248384",{"VOID":403},"https:\u002F\u002Forcid.org\u002F0000-0003-1598-9686",{"EN":405},"P. Harris",{"id":407,"sortIndex":408,"researcher":24,"roles":409,"affiliations":410,"properties":421},"6240fa00-4853-46dc-85ce-928e70f4e511",3,[],[411],{"id":412,"sortIndex":25,"affiliation":413,"properties":24},"d06122fc-eaf6-4982-af08-94d458d19c17",{"id":414,"createTime":415,"updateTime":415,"relativeEntities":416,"slug":417,"properties":418,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"48d41bc2-b99a-4d9e-be41-7b57949bc425","2024-10-05T13:53:55.521+00:00",[],"Imaging-Division-Iatia-Ltd-Box-Hill-Victoria-Australia",{"title":419},{"EN":420},"Imaging Division, Iatia Ltd., Box Hill, Victoria, Australia",{"openalex":422,"title":424},{"VOID":423},"A5056751072",{"EN":425},"B. E. Allman",{"id":427,"sortIndex":428,"researcher":24,"roles":429,"affiliations":430,"properties":437},"81b64ec2-162b-415e-89c4-69e9a78ace32",5,[],[431],{"id":432,"sortIndex":25,"affiliation":433,"properties":24},"2587eb9c-10b3-4401-96ca-c01d3114cc08",{"id":315,"createTime":316,"updateTime":317,"relativeEntities":434,"slug":319,"properties":435,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":436},{"VI":322},{"openalex":438,"orcid":440,"title":442},{"VOID":439},"A5069676334",{"VOID":441},"https:\u002F\u002Forcid.org\u002F0000-0002-2271-5942",{"EN":443},"Alastair G. Stewart",{"id":445,"sortIndex":25,"researcher":24,"roles":446,"affiliations":447,"properties":454},"c0eda938-36ad-4fa2-a0fd-3b41e53ea5e1",[],[448],{"id":449,"sortIndex":25,"affiliation":450,"properties":24},"f0efbe93-6d32-43dd-859e-e4ee834f614d",{"id":335,"createTime":336,"updateTime":337,"relativeEntities":451,"slug":339,"properties":452,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":453},{"VI":342},{"openalex":455,"orcid":457,"title":459},{"VOID":456},"A5067159924",{"VOID":458},"https:\u002F\u002Forcid.org\u002F0000-0002-8092-9236",{"EN":460},"Claire L. Curl",{"id":462,"sortIndex":71,"researcher":24,"roles":463,"affiliations":464,"properties":471},"68ab361e-3b28-4f02-b505-91dc9d418c7b",[],[465],{"id":466,"sortIndex":25,"affiliation":467,"properties":24},"1226ecce-ca88-48f7-ae14-2c6a36f10ee5",{"id":357,"createTime":358,"updateTime":359,"relativeEntities":468,"slug":361,"properties":469,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":470},{"VI":364},{"openalex":472,"orcid":474,"title":476},{"VOID":473},"A5001678639",{"VOID":475},"https:\u002F\u002Forcid.org\u002F0000-0003-4295-9730",{"EN":477},"Ann Roberts",{"url":24,"publisher":479,"properties":504},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":480,"slug":10,"properties":481,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":487,"manageAffiliations":488,"indexDatabases":489,"url":115,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":482,"issn":483,"introduce":484,"eissn":485,"title":486},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[490,497],{"id":96,"indexDatabase":491,"url":111,"indexYears":24,"academicFieldIds":496,"indexDatabaseRanking":24},{"id":98,"createTime":99,"updateTime":100,"relativeEntities":492,"label":493,"description":494,"key":107,"publicationTags":495,"standard":24},[],{"EN":103,"VI":103},{"VI":105,"EN":106},[109,110],[113,114],{"id":75,"indexDatabase":498,"url":88,"indexYears":89,"academicFieldIds":503,"indexDatabaseRanking":94},{"id":77,"createTime":78,"updateTime":79,"relativeEntities":499,"label":500,"description":501,"key":85,"publicationTags":502,"standard":24},[],{"EN":82,"VI":82},{"EN":82,"VI":84},[87],[91,92,93],{"volume":505,"pages":507,"issue":509},{"VOID":506},"65A",{"VOID":508},"88-92",{"VOID":510},"1",199,{"total":511,"publishYear":24,"statisticByYear":513},{"2012":218,"2013":514,"2014":515,"2015":516,"2016":516,"2017":517,"2018":518,"2019":514,"2020":519,"2021":218,"2022":372,"2023":71,"2024":309},12,11,15,18,9,14,"2005-05-01",2005,[523,526,529,532,535,538,541,544,547,550,553,556,559,562,565,568,571,574,577,580,583,586,589,592],{"id":24,"text":524,"url":24,"identifiers":525},"10.1364\u002FAO.38.003651",{"doi":524},{"id":24,"text":527,"url":24,"identifiers":528},"10.1364\u002FOL.19.002062",{"doi":527},{"id":24,"text":530,"url":24,"identifiers":531},"10.1117\u002F12.231370",{"doi":530},{"id":24,"text":533,"url":24,"identifiers":534},"10.1117\u002F1.1463043",{"doi":533},{"id":24,"text":536,"url":24,"identifiers":537},"10.1083\u002Fjcb.82.3.767",{"doi":536},{"id":24,"text":539,"url":24,"identifiers":540},"10.1088\u002F0031-9155\u002F41\u002F3\u002F002",{"doi":539},{"id":24,"text":542,"url":24,"identifiers":543},"10.1364\u002FJOSA.47.000545",{"doi":542},{"id":24,"text":545,"url":24,"identifiers":546},"Ross KFA, 1967, Phase contrast and interference microscopy for cell biologists",{},{"id":24,"text":548,"url":24,"identifiers":549},"10.1364\u002FOL.23.000817",{"doi":548},{"id":24,"text":551,"url":24,"identifiers":552},"10.1103\u002FPhysRevLett.80.2586",{"doi":551},{"id":24,"text":554,"url":24,"identifiers":555},"10.1046\u002Fj.1365-2818.2002.01027.x",{"doi":554},{"id":24,"text":557,"url":24,"identifiers":558},"10.1364\u002FOL.27.002061",{"doi":557},{"id":24,"text":560,"url":24,"identifiers":561},"10.1111\u002Fj.0022-2720.2004.01302.x",{"doi":560},{"id":24,"text":563,"url":24,"identifiers":564},"10.1038\u002Fsj.bjp.0701128",{"doi":563},{"id":24,"text":566,"url":24,"identifiers":567},"10.1016\u002FS0006-3495(96)79711-4",{"doi":566},{"id":24,"text":569,"url":24,"identifiers":570},"Visser TD, 1992, Refractive index and axial distance measurements in 3‐D microscopy, Optik, 90, 17",{},{"id":24,"text":572,"url":24,"identifiers":573},"10.1046\u002Fj.1365-2818.1997.d01-627.x",{"doi":572},{"id":24,"text":575,"url":24,"identifiers":576},"Roper Scientific. Available at:www.roperscientific.com.",{},{"id":24,"text":578,"url":24,"identifiers":579},"10.1007\u002Fs00424-004-1248-7",{"doi":578},{"id":24,"text":581,"url":24,"identifiers":582},"10.1364\u002FAO.28.002297",{"doi":581},{"id":24,"text":584,"url":24,"identifiers":585},"Olympus Microscopy Resource Center. Available at:www.olympusmicro.com\u002Fprimer\u002Ftechniques\u002Ffluorescence\u002Ftirf\u002Ftirfintro.html.",{},{"id":24,"text":587,"url":24,"identifiers":588},"Delbridge LMD, 2002, Quantitative phase imaging—a new way to ‘see’ cells, Today Life Sci, 14, 28",{},{"id":24,"text":590,"url":24,"identifiers":591},"Iatia Ltd. Available at:www.iatia.com.au\u002Fapplications\u002Fapps_confocal.asp.",{},{"id":24,"text":593,"url":24,"identifiers":594},"10.1111\u002Fj.1440-1681.2004.04100.x",{"doi":593},{"id":596,"createTime":597,"updateTime":598,"relativeEntities":599,"slug":600,"properties":601,"entityType":139,"verifyStatus":140,"verifyTime":620,"verifyNote":141,"syncStatus":23,"languages":621,"translateLanguages":622,"viewCount":25,"primaryUrl":623,"fullTextUrl":24,"authors":624,"publicationType":184,"publisherRelationship":732,"citationCount":764,"citationInfo":765,"publishDate":772,"publishYear":773,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":774,"isForceReanalyzing":278},"ec24753c-3235-459a-a59b-eed80db9cfb3","2024-09-25T06:13:26.084+00:00","2025-02-03T18:54:26.825+00:00",[],"Rapid-cell-population-identification-in-flow-cytometry-data",{"mag":602,"keywords":604,"pmc":606,"openalex":608,"abstract":610,"title":613,"pm":616,"doi":618},{"VOID":603},"2114124472",{"VI":605},"phân tích dòng chảy, K-means, quần thể tế bào, thuật toán tự động, mã nguồn mở",{"VOID":607},"3137288",{"VOID":609},"W2114124472",{"VI":611,"EN":612},"\u003Cjats:title>Giới thiệu\u003C\u002Fjats:title>\u003Cjats:p>Chúng tôi đã phát triển flowMeans, một phương pháp hiệu quả về thời gian và chính xác để tự động xác định các quần thể tế bào trong dữ liệu phân tích dòng chảy (FCM) dựa trên phân cụm K-means. Khác với K-means truyền thống, flowMeans có thể xác định các quần thể tế bào lõm bằng cách mô hình hóa một quần thể duy nhất với nhiều cụm. flowMeans sử dụng một thuật toán phát hiện điểm thay đổi để xác định số lượng tiểu quần thể, cho phép phương pháp này được sử dụng trong các quy trình phân tích dữ liệu FCM với quy mô lớn. Cách tiếp cận của chúng tôi cho kết quả so với phân tích thủ công của các chuyên gia con người và các thuật toán phân loại tự động tiên tiến hiện tại. flowMeans được cung cấp miễn phí dưới dạng gói mã nguồn mở R thông qua Bioconductor. © 2010 Hiệp hội Quốc tế Phát triển Phân tích tế bào.\u003C\u002Fjats:p>","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>We have developed flowMeans, a time‐efficient and accurate method for automated identification of cell populations in flow cytometry (FCM) data based on K‐means clustering. Unlike traditional K‐means, flowMeans can identify concave cell populations by modelling a single population with multiple clusters. flowMeans uses a change point detection algorithm to determine the number of sub‐populations, enabling the method to be used in high throughput FCM data analysis pipelines. Our approach compares favorably to manual analysis by human experts and current state‐of‐the‐art automated gating algorithms. flowMeans is freely available as an open source R package through Bioconductor. © 2010 International Society for Advancement of Cytometry\u003C\u002Fjats:p>",{"VI":614,"EN":615},"Xác định quần thể tế bào nhanh chóng trong dữ liệu phân tích dòng chảy","Rapid cell population identification in flow cytometry data",{"VOID":617},"21182178",{"VOID":619},"10.1002\u002Fcyto.a.21007","2024-09-25T06:13:26.082+00:00",[143],[304],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcyto.a.21007",[625,657,685,711],{"id":626,"sortIndex":25,"researcher":24,"roles":627,"affiliations":628,"properties":650},"1344b356-ab6b-404f-94e4-c3322530d167",[],[629,639],{"id":630,"sortIndex":25,"affiliation":631,"properties":24},"ee4561c7-41cd-45bb-8e46-5eec87eccc90",{"id":632,"createTime":633,"updateTime":633,"relativeEntities":634,"slug":635,"properties":636,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"6ea92d18-68a7-412d-940d-66d641ac369b","2024-09-25T06:13:26.149+00:00",[],"Department-of-Bioinformatics-University-of-British-Columbia-British-Columbia-Canada",{"title":637},{"EN":638},"Department of Bioinformatics, University of British Columbia, British Columbia, Canada",{"id":640,"sortIndex":148,"affiliation":641,"properties":24},"dfd9a08e-9545-4271-9ed3-dc1c2469724f",{"id":642,"createTime":643,"updateTime":644,"relativeEntities":645,"slug":646,"properties":647,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"781f4bc9-c93b-42b1-84e9-c0fe79b27185","2024-01-10T21:57:15.747+00:00","2024-09-25T06:13:26.173+00:00",[],"Terry-Fox-Laboratory-BC-Cancer-Agency-Vancouver-British-Columbia-Canada-",{"title":648},{"VI":649},"Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada.",{"openalex":651,"orcid":653,"title":655},{"VOID":652},"A5031425035",{"VOID":654},"https:\u002F\u002Forcid.org\u002F0000-0002-6117-8764",{"EN":656},"Nima Aghaeepour",{"id":658,"sortIndex":408,"researcher":24,"roles":659,"affiliations":660,"properties":678},"4223bafb-ae07-47ee-b6f9-ee5cd5df36c7",[],[661,672],{"id":662,"sortIndex":25,"affiliation":663,"properties":24},"ee576737-dfcd-4f2f-b284-36cf7c096d11",{"id":664,"createTime":665,"updateTime":666,"relativeEntities":667,"slug":668,"properties":669,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"5567bf93-2d05-455b-bfed-8bb50c36cbb7","2024-01-24T02:27:22.037+00:00","2024-09-25T06:13:26.278+00:00",[],"Department-of-Medical-Genetics-University-of-British-Columbia-British-Columbia-Canada-",{"title":670},{"VI":671},"Department of Medical Genetics, University of British Columbia, British Columbia, Canada;",{"id":673,"sortIndex":148,"affiliation":674,"properties":24},"3e7b9fbb-be83-42b7-8b50-bc49a1bca20d",{"id":642,"createTime":643,"updateTime":644,"relativeEntities":675,"slug":646,"properties":676,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":677},{"VI":649},{"openalex":679,"orcid":681,"title":683},{"VOID":680},"A5035285628",{"VOID":682},"https:\u002F\u002Forcid.org\u002F0000-0002-9765-2990",{"EN":684},"Ryan R. Brinkman",{"id":686,"sortIndex":148,"researcher":24,"roles":687,"affiliations":688,"properties":706},"23abc9ca-b33d-45ec-921c-5915366c55b9",[],[689,695],{"id":690,"sortIndex":148,"affiliation":691,"properties":24},"241ca370-6210-49d5-87c9-cb3d19549680",{"id":642,"createTime":643,"updateTime":644,"relativeEntities":692,"slug":646,"properties":693,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":694},{"VI":649},{"id":696,"sortIndex":25,"affiliation":697,"properties":24},"44c855d2-9b8d-43cd-a629-cf05fbf3a741",{"id":698,"createTime":699,"updateTime":700,"relativeEntities":701,"slug":702,"properties":703,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"0222ce1d-736c-406e-9ad9-31967ca9094e","2024-01-14T10:47:36.258+00:00","2025-06-11T15:33:51.561+00:00",[],"Department-of-Statistics-University-of-Oxford-Oxford-United-Kingdom",{"title":704},{"VI":705},"Department of Statistics, University of Oxford, Oxford, United Kingdom",{"openalex":707,"title":709},{"VOID":708},"A5000623670",{"EN":710},"Radina Nikolic",{"id":712,"sortIndex":309,"researcher":24,"roles":713,"affiliations":714,"properties":725},"b74851de-1448-4d29-a455-5fdc4f1de393",[],[715],{"id":716,"sortIndex":25,"affiliation":717,"properties":24},"5ebce14c-1d48-4acd-925a-15fa5c7a7b95",{"id":718,"createTime":719,"updateTime":719,"relativeEntities":720,"slug":721,"properties":722,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"2b907c19-559b-44fb-8ab8-f412c523d952","2024-09-25T06:13:26.251+00:00",[],"Department-of-Computer-Science-University-of-British-Columbia-British-Columbia-Canada",{"title":723},{"EN":724},"Department of Computer Science, University of British Columbia, British Columbia, Canada",{"openalex":726,"orcid":728,"title":730},{"VOID":727},"A5025342513",{"VOID":729},"https:\u002F\u002Forcid.org\u002F0000-0003-0629-0099",{"EN":731},"Holger H. Hoos",{"url":24,"publisher":733,"properties":758},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":734,"slug":10,"properties":735,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":741,"manageAffiliations":742,"indexDatabases":743,"url":115,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":736,"issn":737,"introduce":738,"eissn":739,"title":740},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[744,751],{"id":96,"indexDatabase":745,"url":111,"indexYears":24,"academicFieldIds":750,"indexDatabaseRanking":24},{"id":98,"createTime":99,"updateTime":100,"relativeEntities":746,"label":747,"description":748,"key":107,"publicationTags":749,"standard":24},[],{"EN":103,"VI":103},{"VI":105,"EN":106},[109,110],[113,114],{"id":75,"indexDatabase":752,"url":88,"indexYears":89,"academicFieldIds":757,"indexDatabaseRanking":94},{"id":77,"createTime":78,"updateTime":79,"relativeEntities":753,"label":754,"description":755,"key":85,"publicationTags":756,"standard":24},[],{"EN":82,"VI":82},{"EN":82,"VI":84},[87],[91,92,93],{"volume":759,"pages":761,"issue":763},{"VOID":760},"79A",{"VOID":762},"6-13",{"VOID":510},210,{"total":764,"publishYear":24,"statisticByYear":766},{"2012":514,"2013":519,"2014":767,"2015":768,"2016":769,"2017":516,"2018":516,"2019":770,"2020":516,"2021":771,"2022":771,"2023":519,"2024":771},17,23,21,16,13,"2011-01-01",2011,[775,778,781,784,787,790,793,796,799,802,805,809,812,815,818,822,825,828,831,834,837,840,843,846,850,853],{"id":24,"text":776,"url":24,"identifiers":777},"10.1002\u002Fcyto.a.20617",{"doi":776},{"id":24,"text":779,"url":24,"identifiers":780},"10.1002\u002Fcyto.a.20905",{"doi":779},{"id":24,"text":782,"url":24,"identifiers":783},"10.1002\u002Fcyto.a.20901",{"doi":782},{"id":24,"text":785,"url":24,"identifiers":786},"10.1016\u002Fj.leukres.2007.08.022",{"doi":785},{"id":24,"text":788,"url":24,"identifiers":789},"10.1002\u002Fcyto.10084",{"doi":788},{"id":24,"text":791,"url":24,"identifiers":792},"10.1515\u002FCCLM.2003.052",{"doi":791},{"id":24,"text":794,"url":24,"identifiers":795},"Hahne F, 2009, Per‐channel basis normalization methods for flow cytometry data, Cytometry Part A, 77, 121",{},{"id":24,"text":797,"url":24,"identifiers":798},"Bashashati A, 2009, A Survey of Flow Cytometry Data Analysis Methods, Adv Bioinformatics, 584603",{},{"id":24,"text":800,"url":24,"identifiers":801},"10.1002\u002Fcyto.a.20531",{"doi":800},{"id":24,"text":803,"url":24,"identifiers":804},"Finak G, 2009, Merging mixture model components for improved cell population identification in high throughput flow cytometry data, Advances in Bioinformatics, 100",{},{"id":24,"text":806,"url":24,"identifiers":807},"BaudryJ RafteryA CeleuxG LoK GottardoR.Combining mixture components for clustering. Journal of Computational and Graphical Statistics 2010;19:332–353.",{"doi":808},"10.1198\u002Fjcgs.2010.08111",{"id":24,"text":810,"url":24,"identifiers":811},"10.1073\u002Fpnas.0903028106",{"doi":810},{"id":24,"text":813,"url":24,"identifiers":814},"10.1002\u002Fcyto.a.20754",{"doi":813},{"id":24,"text":816,"url":24,"identifiers":817},"10.1186\u002F1471-2105-11-403",{"doi":816},{"id":24,"text":819,"url":24,"identifiers":820},"Murphy R, 2005, Automated identification of subpopulations in flow cytometric list mode data using cluster analysis, Cytometry Part A, 6, 302, 10.1002\u002Fcyto.990060405",{"doi":821},"10.1002\u002Fcyto.990060405",{"id":24,"text":823,"url":24,"identifiers":824},"Pelleg D, 2000, Proceedings of the Seventeenth International Conference on Machine Learning table of contents, 727",{},{"id":24,"text":826,"url":24,"identifiers":827},"Hamerly G, 2004, Learning the K in k‐means, Advances in Neural Information Processing Systems, 17, 281",{},{"id":24,"text":829,"url":24,"identifiers":830},"10.1002\u002F9780470316801",{"doi":829},{"id":24,"text":832,"url":24,"identifiers":833},"10.1016\u002Fj.csda.2008.02.035",{"doi":832},{"id":24,"text":835,"url":24,"identifiers":836},"10.1002\u002F9780470316849",{"doi":835},{"id":24,"text":838,"url":24,"identifiers":839},"RosenbergA HirschbergJ.V‐measure: A conditional entropy‐based external cluster evaluation measure. In Proceedings of the 2007 Joint Conference on Empirical Methods in Natural Language Processing and Computational Natural Language Learning (EMNLP‐CoNLL); Prague Czech Republic.2007. p410–420.",{},{"id":24,"text":841,"url":24,"identifiers":842},"AghaeepourN KhodabakhshiAH BrinkmanRR. An empirical study of cluster evaluation metrics using flow cytometry data. Clustering Theory Workshop Neural Information Processing Systems (NIPS). Whistler British Columbia Canada December 2009.http:\u002F\u002Fclusteringtheory.org\u002Fpapers\u002Fempiricalmetrics.pdf.",{},{"id":24,"text":844,"url":24,"identifiers":845},"10.1016\u002Fj.bbmt.2007.02.002",{"doi":844},{"id":24,"text":847,"url":24,"identifiers":848},"IgelC SuttorpT HansenN.A computational efficient covariance matrix update and a (1+ 1)‐CMA for evolution strategies. In Proceedings of the 8th annual conference on Genetic and Evolutionary Computation GECCO ’︁06. New York: ACM. ISBN 1‐59593‐186‐4; 2006: p 453–460.",{"doi":849},"10.1145\u002F1143997.1144082",{"id":24,"text":851,"url":24,"identifiers":852},"AghaeepourN. FlowMeans package at Bioconductor Available at:http:\u002F\u002Fwww.bioconductor.org\u002Fpackages\u002Fdevel\u002Fbioc\u002Fhtml\u002FflowMeans.html.2010.",{},{"id":24,"text":854,"url":24,"identifiers":855},"10.1186\u002Fgb-2004-5-10-r80",{"doi":854},{"id":857,"createTime":858,"updateTime":859,"relativeEntities":860,"slug":861,"properties":862,"entityType":139,"verifyStatus":140,"verifyTime":880,"verifyNote":141,"syncStatus":23,"languages":881,"translateLanguages":882,"viewCount":25,"primaryUrl":883,"fullTextUrl":24,"authors":884,"publicationType":184,"publisherRelationship":976,"citationCount":1009,"citationInfo":1010,"publishDate":1016,"publishYear":1017,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1018,"isForceReanalyzing":278},"618e0b32-654f-43de-90ad-34a156fe84c0","2024-09-28T04:58:22.792+00:00","2025-02-03T18:53:27.652+00:00",[],"Single-cell-mass-cytometry-adapted-to-measurements-of-the-cell-cycle",{"mag":863,"keywords":865,"pmc":866,"openalex":868,"abstract":870,"title":873,"pm":876,"doi":878},{"VOID":864},"2016322906",{"VI":289},{"VOID":867},"3667754",{"VOID":869},"W2016322906",{"VI":871,"EN":872},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Cytometry khối lượng là một công nghệ mới được giới thiệu, sử dụng kháng thể gắn đồng vị của nguyên tố chuyển tiếp để phát hiện protein trên cơ sở từng tế bào. Bằng cách vượt qua các hạn chế của sự chồng chéo quang phổ phát xạ liên quan đến các fluorochrome sử dụng trong cytometry dòng truyền thống, cytometry khối lượng hiện cho phép đo tới 40 thông số trên mỗi tế bào. Gần đây, một phân tích cytometry khối lượng toàn diện đã được mô tả cho chương trình phân biệt huyết học trong tủy xương của người từ một người hiến máu khỏe mạnh. Nghiên cứu hiện tại mô tả các phương pháp để phân đoạn các giai đoạn chu kỳ tế bào bằng cách sử dụng 5-iodo-2-deoxyuridine (IdU) để đánh dấu các tế bào trong giai đoạn S, đồng thời với các kháng thể chống lại cyclin B1, cyclin A và histone H3 phosphoryl hóa (S28) đặc trưng cho các giai đoạn chu kỳ tế bào khác. Các quy trình đã được phát triển trong đó một kháng thể chống lại protein retinoblastoma phosphoryl hóa (Rb) tại các serine 807 và 811 được sử dụng để tách biệt các tế bào ở các giai đoạn G0 và G1 của chu kỳ tế bào. Phương pháp cytometry khối lượng này đã cho ra các phân bố chu kỳ tế bào của cả quần thể tế bào bình thường và tế bào ung thư mà tương đương với những gì thu được từ các kỹ thuật cytometry huỳnh quang truyền thống. Chúng tôi đã áp dụng điều này để vẽ bản đồ các giai đoạn chu kỳ tế bào của các tế bào trải rộng qua hệ thống huyết học trong tủy xương người khỏe mạnh như một sự chuẩn bị cho các nghiên cứu sau này với ung thư và các rối loạn khác của dòng này. © 2012 Hiệp hội Quốc tế vì sự Tiến bộ của Cytometry\u003C\u002Fjats:p>","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Mass cytometry is a recently introduced technology that utilizes transition element isotope‐tagged antibodies for protein detection on a single‐cell basis. By circumventing the limitations of emission spectral overlap associated with fluorochromes utilized in traditional flow cytometry, mass cytometry currently allows measurement of up to 40 parameters per cell. Recently, a comprehensive mass cytometry analysis was described for the hematopoietic differentiation program in human bone marrow from a healthy donor. The current study describes approaches to delineate cell cycle stages utilizing 5‐iodo‐2‐deoxyuridine (IdU) to mark cells in S phase, simultaneously with antibodies against cyclin B1, cyclin A, and phosphorylated histone H3 (S28) that characterize the other cell cycle phases. Protocols were developed in which an antibody against phosphorylated retinoblastoma protein (Rb) at serines 807 and 811 was used to separate cells in G0 and G1 phases of the cell cycle. This mass cytometry method yielded cell cycle distributions of both normal and cancer cell populations that were equivalent to those obtained by traditional fluorescence cytometry techniques. We applied this to map the cell cycle phases of cells spanning the hematopoietic hierarchy in healthy human bone marrow as a prelude to later studies with cancers and other disorders of this lineage. © 2012 International Society for Advancement of Cytometry\u003C\u002Fjats:p>",{"VI":874,"EN":875},"Biểu đồ tế bào đơn với phương pháp phân tích khối lượng thích ứng cho việc đo lường chu kỳ tế bào","Single‐cell mass cytometry adapted to measurements of the cell cycle",{"VOID":877},"22693166",{"VOID":879},"10.1002\u002Fcyto.a.22075","2024-09-28T04:58:22.791+00:00",[143],[304],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcyto.a.22075",[885,906,927,944,961],{"id":886,"sortIndex":25,"researcher":24,"roles":887,"affiliations":888,"properties":899},"898ca04a-a505-4c43-b485-c77f04f1dd15",[],[889],{"id":890,"sortIndex":25,"affiliation":891,"properties":24},"339a8974-cf2b-40f3-9e9c-df4e5292a3bb",{"id":892,"createTime":893,"updateTime":893,"relativeEntities":894,"slug":895,"properties":896,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"4a76af55-e068-4fc5-a638-a08333332fb9","2024-09-28T04:58:22.813+00:00",[],"Baxter-Laboratory-for-Stem-Cell-Biology-Department-of-Microbiology-and-Immunology-Stanford-University-School-of-Medicine-Stanford-CA-94305-USA-",{"title":897},{"EN":898},"Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, 94305, USA.",{"openalex":900,"orcid":902,"title":904},{"VOID":901},"A5024815439",{"VOID":903},"https:\u002F\u002Forcid.org\u002F0000-0002-9493-3607",{"EN":905},"Gregory K. Behbehani",{"id":907,"sortIndex":408,"researcher":24,"roles":908,"affiliations":909,"properties":920},"53258cd9-d4ac-4758-8310-d6aaeccd07e7",[],[910],{"id":911,"sortIndex":25,"affiliation":912,"properties":24},"6ad06bba-e950-485b-a063-bb00abcc13b8",{"id":913,"createTime":914,"updateTime":914,"relativeEntities":915,"slug":916,"properties":917,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"ded22148-9d4e-401e-9f04-01610b9264fd","2024-09-28T04:58:22.824+00:00",[],"Baxter-Laboratory-for-Stem-Cell-Biology-Department-of-Microbiology-Immunology-Stanford-University-School-of-Medicine-Stanford-CA",{"title":918},{"EN":919},"Baxter Laboratory for Stem Cell Biology, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA",{"openalex":921,"orcid":923,"title":925},{"VOID":922},"A5071972147",{"VOID":924},"https:\u002F\u002Forcid.org\u002F0000-0003-3452-7292",{"EN":926},"Wendy J. Fantl",{"id":928,"sortIndex":148,"researcher":24,"roles":929,"affiliations":930,"properties":937},"a677fdc4-76f7-491a-8898-9814e372f442",[],[931],{"id":932,"sortIndex":25,"affiliation":933,"properties":24},"3099f850-22be-4faa-a967-916482d103ac",{"id":913,"createTime":914,"updateTime":914,"relativeEntities":934,"slug":916,"properties":935,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":936},{"EN":919},{"openalex":938,"orcid":940,"title":942},{"VOID":939},"A5045383208",{"VOID":941},"https:\u002F\u002Forcid.org\u002F0000-0003-1341-2453",{"EN":943},"Sean C. Bendall",{"id":945,"sortIndex":390,"researcher":24,"roles":946,"affiliations":947,"properties":954},"5af4e0b1-bb6b-43ce-a03c-9b3c0c21477b",[],[948],{"id":949,"sortIndex":25,"affiliation":950,"properties":24},"274df546-2eb9-4721-aa79-223ca17e7e48",{"id":913,"createTime":914,"updateTime":914,"relativeEntities":951,"slug":916,"properties":952,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":953},{"EN":919},{"openalex":955,"orcid":957,"title":959},{"VOID":956},"A5033995613",{"VOID":958},"https:\u002F\u002Forcid.org\u002F0000-0002-8862-9043",{"EN":960},"Garry P. Nolan",{"id":962,"sortIndex":309,"researcher":24,"roles":963,"affiliations":964,"properties":971},"f9f24c95-e597-49c1-99a0-4d4439aab7e9",[],[965],{"id":966,"sortIndex":25,"affiliation":967,"properties":24},"859f3f22-bb06-44b5-9951-3c8bb48af27b",{"id":913,"createTime":914,"updateTime":914,"relativeEntities":968,"slug":916,"properties":969,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":970},{"EN":919},{"openalex":972,"title":974},{"VOID":973},"A5005588883",{"EN":975},"Matthew R. Clutter",{"url":24,"publisher":977,"properties":1002},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":978,"slug":10,"properties":979,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":985,"manageAffiliations":986,"indexDatabases":987,"url":115,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":980,"issn":981,"introduce":982,"eissn":983,"title":984},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[988,995],{"id":96,"indexDatabase":989,"url":111,"indexYears":24,"academicFieldIds":994,"indexDatabaseRanking":24},{"id":98,"createTime":99,"updateTime":100,"relativeEntities":990,"label":991,"description":992,"key":107,"publicationTags":993,"standard":24},[],{"EN":103,"VI":103},{"VI":105,"EN":106},[109,110],[113,114],{"id":75,"indexDatabase":996,"url":88,"indexYears":89,"academicFieldIds":1001,"indexDatabaseRanking":94},{"id":77,"createTime":78,"updateTime":79,"relativeEntities":997,"label":998,"description":999,"key":85,"publicationTags":1000,"standard":24},[],{"EN":82,"VI":82},{"EN":82,"VI":84},[87],[91,92,93],{"volume":1003,"pages":1005,"issue":1007},{"VOID":1004},"81A",{"VOID":1006},"552-566",{"VOID":1008},"7",218,{"total":1009,"publishYear":24,"statisticByYear":1011},{"2012":71,"2013":514,"2014":519,"2015":1012,"2016":1013,"2017":769,"2018":768,"2019":1014,"2020":1015,"2021":519,"2022":768,"2023":517,"2024":518},19,10,22,27,"2012-07-01",2012,[1019,1022,1025,1028,1031,1034,1038,1042,1045,1049,1052,1055,1058,1061,1064,1067,1070,1073,1076,1079,1082,1085,1088,1091,1094,1097,1100,1103,1106,1109,1113,1116],{"id":24,"text":1020,"url":24,"identifiers":1021},"10.1016\u002Fj.jim.2005.09.020",{"doi":1020},{"id":24,"text":1023,"url":24,"identifiers":1024},"10.1039\u002Fb710510j",{"doi":1023},{"id":24,"text":1026,"url":24,"identifiers":1027},"10.1021\u002Fac901049w",{"doi":1026},{"id":24,"text":1029,"url":24,"identifiers":1030},"10.1126\u002Fscience.1198704",{"doi":1029},{"id":24,"text":1032,"url":24,"identifiers":1033},"10.1038\u002Fnbt.1991",{"doi":1032},{"id":24,"text":1035,"url":24,"identifiers":1036},"Griffin J, 1986, Clonogenic cells in acute myeloblastic leukemia, Blood, 68, 1185–1195, 10.1182\u002Fblood.V68.6.1185.1185",{"doi":1037},"10.1182\u002Fblood.V68.6.1185.1185",{"id":24,"text":1039,"url":24,"identifiers":1040},"Moore MA, 1974, Agar culture studies in 127 cases of untreated acute leukemia: The prognostic value of reclassification of leukemia according to in vitro growth characteristics, Blood, 44, 1–18, 10.1182\u002Fblood.V44.1.1.1",{"doi":1041},"10.1182\u002Fblood.V44.1.1.1",{"id":24,"text":1043,"url":24,"identifiers":1044},"Raza A, 1997, Cell cycle kinetic studies in 68 patients with myelodysplastic syndromes following intravenous iodo‐ and\u002For bromodeoxyuridine, Exp Hematol, 25, 530",{},{"id":24,"text":1046,"url":24,"identifiers":1047},"Pearce DJ, 2006, AML engraftment in the NOD\u002FSCID assay reflects the outcome of AML: Implications for our understanding of the heterogeneity of AML, Blood, 107, 1166–1173, 10.1182\u002Fblood-2005-06-2325",{"doi":1048},"10.1182\u002Fblood-2005-06-2325",{"id":24,"text":1050,"url":24,"identifiers":1051},"10.1186\u002F1471-2105-10-106",{"doi":1050},{"id":24,"text":1053,"url":24,"identifiers":1054},"10.1002\u002F0471142956.cy1017s53",{"doi":1053},{"id":24,"text":1056,"url":24,"identifiers":1057},"van Lochem EG, 2004, Immunophenotypic differentiation patterns of normal hematopoiesis in human bone marrow: Reference patterns for age‐related changes and disease‐induced shifts, Cytometry Part B: Clinical Cytometry, 60, 1–13",{},{"id":24,"text":1059,"url":24,"identifiers":1060},"10.1021\u002Fac702128m",{"doi":1059},{"id":24,"text":1062,"url":24,"identifiers":1063},"10.1002\u002Fcyto.a.20252",{"doi":1062},{"id":24,"text":1065,"url":24,"identifiers":1066},"10.1016\u002FS0092-8674(04)00300-9",{"doi":1065},{"id":24,"text":1068,"url":24,"identifiers":1069},"10.1002\u002F(SICI)1097-0320(19960901)25:1\u003C1::AID-CYTO1>3.0.CO;2-N",{"doi":1068},{"id":24,"text":1071,"url":24,"identifiers":1072},"10.1002\u002F0471142956.cy0724s28",{"doi":1071},{"id":24,"text":1074,"url":24,"identifiers":1075},"10.1007\u002F978-1-61737-950-5_11",{"doi":1074},{"id":24,"text":1077,"url":24,"identifiers":1078},"10.1046\u002Fj.1356-9597.2001.00498.x",{"doi":1077},{"id":24,"text":1080,"url":24,"identifiers":1081},"10.1369\u002Fjhc.4A6285.2004",{"doi":1080},{"id":24,"text":1083,"url":24,"identifiers":1084},"10.1002\u002F0471142956.cy0703s30",{"doi":1083},{"id":24,"text":1086,"url":24,"identifiers":1087},"10.1089\u002Fscd.2007.0017",{"doi":1086},{"id":24,"text":1089,"url":24,"identifiers":1090},"10.2353\u002Fajpath.2006.060312",{"doi":1089},{"id":24,"text":1092,"url":24,"identifiers":1093},"10.1002\u002Fcyto.a.20003",{"doi":1092},{"id":24,"text":1095,"url":24,"identifiers":1096},"10.1158\u002F1078-0432.CCR-09-0787",{"doi":1095},{"id":24,"text":1098,"url":24,"identifiers":1099},"2011, Asymmetric cancer cell division regulated by AKT, Proc Natl Acad Sci, 108, 12845–12850",{},{"id":24,"text":1101,"url":24,"identifiers":1102},"Gong J, 1994, Unscheduled expression of Cyclin B1 and Cyclin E in several leukemic and solid tumor cell lines, Cancer Res, 54, 4285–4288",{},{"id":24,"text":1104,"url":24,"identifiers":1105},"10.1101\u002Fsqb.2008.73.031",{"doi":1104},{"id":24,"text":1107,"url":24,"identifiers":1108},"10.1073\u002Fpnas.96.6.3120",{"doi":1107},{"id":24,"text":1110,"url":24,"identifiers":1111},"Passegue E, 2005, Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates, J Exp Med, 202, 1599–1611, 10.1084\u002Fjem.20050967",{"doi":1112},"10.1084\u002Fjem.20050967",{"id":24,"text":1114,"url":24,"identifiers":1115},"Head DR, 2011, Innovative analyses support a role for DNA damage and an aberrant cell cycle in myelodysplastic syndrome pathogenesis, Bone Marrow Res, 2011",{},{"id":24,"text":1117,"url":24,"identifiers":1118},"Preisler H, 1980, Prediction of response to chemotherapy in acute myelocytic leukemia, Blood, 56, 361–367, 10.1182\u002Fblood.V56.3.361.361",{"doi":1119},"10.1182\u002Fblood.V56.3.361.361",{"id":1121,"createTime":1122,"updateTime":1123,"relativeEntities":1124,"slug":1125,"properties":1126,"entityType":139,"verifyStatus":140,"verifyTime":1122,"verifyNote":141,"syncStatus":23,"languages":1143,"translateLanguages":1144,"viewCount":25,"primaryUrl":1145,"fullTextUrl":24,"authors":1146,"publicationType":184,"publisherRelationship":1236,"citationCount":1268,"citationInfo":1269,"publishDate":1272,"publishYear":1273,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1274,"isForceReanalyzing":278},"ae15dd4e-83f3-434a-952c-dce4169e8982","2024-10-05T00:39:47.355+00:00","2025-02-03T18:52:29.837+00:00",[],"Detection-of-TiO-sub-2-sub-nanoparticles-in-cells-by-flow-cytometry",{"mag":1127,"keywords":1129,"openalex":1131,"abstract":1133,"title":1136,"pm":1139,"doi":1141},{"VOID":1128},"2069467605",{"VI":1130},"hạt nano TiO\u003Csub>2\u003C\u002Fsub>; phân tích tế bào chảy; độc tính tế bào; vi kính trường tối; hạt nano; tế bào ARPE‐19",{"VOID":1132},"W2069467605",{"VI":1134,"EN":1135},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Việc đánh giá các mối nguy tiềm ẩn của vật liệu nano do con người tạo ra đã bị cản trở bởi khả năng quan sát và đo lường hạn chế các hạt nano trong tế bào. Trong nghiên cứu này, các nồng độ khác nhau của hạt nano TiO\u003Cjats:sub>2\u003C\u002Fjats:sub> đã được hòa trộn trong môi trường nuôi cấy tế bào. Suspensions sau đó được siêu âm và phân tích bằng phương pháp tán xạ ánh sáng động và vi kính. Các tế bào biểu mô sắc tố võng mạc (ARPE‐19) được nuôi cấy từ người đã được ủ với các hạt nano TiO\u003Cjats:sub>2\u003C\u002Fjats:sub> tại các nồng độ 0, 0.1, 0.3, 1, 3, 10 và 30 μg\u002Fml trong 24 giờ. Các phản ứng của tế bào đối với các hạt nano đã được đánh giá bằng phương pháp phân tích tế bào chảy và vi kính trường tối. Máy phân tích tế bào chảy FACSCalibur™ đã được sử dụng để đo các thay đổi trong tán xạ ánh sáng sau khi ủ với hạt nano. Cả tán xạ bên và tán xạ phía trước đều thay đổi đáng kể phản ánh sự hiện diện của TiO\u003Cjats:sub>2\u003C\u002Fjats:sub>. Từ 0.1 đến 30 μg\u002Fml TiO\u003Cjats:sub>2\u003C\u002Fjats:sub>, tán xạ bên tăng liên tục trong khi tán xạ phía trước giảm, có thể do sự phản xạ ánh sáng mạnh bởi các hạt TiO\u003Cjats:sub>2\u003C\u002Fjats:sub>. Dựa trên các tham số hình thái và xét nghiệm khả năng sống sót calcein‐AM\u002Fiodide propidium, các nồng độ TiO\u003Cjats:sub>2\u003C\u002Fjats:sub> dưới 30 μg\u002Fml TiO\u003Cjats:sub>2\u003C\u002Fjats:sub> gây độc tế bào tối thiểu. Phân tích kính hiển vi được thực hiện trên cùng các tế bào bằng kính hiển vi Nikon E‐800 có nguồn sáng xenon và các vật kính trường tối đặc biệt. Tại các nồng độ thấp nhất của TiO\u003Cjats:sub>2\u003C\u002Fjats:sub> (0.1–0.3 μg\u002Fml), máy phân tích tế bào chảy có thể phát hiện ít nhất 5–10 hạt nano trong mỗi tế bào do sự tán xạ ánh sáng mạnh từ TiO\u003Cjats:sub>2\u003C\u002Fjats:sub>. Các vòng hạt nano tập trung được quan sát quanh các nhân ở gần lưới nội mô tại các nồng độ cao hơn. Các dữ liệu này cho thấy rằng sự hấp thụ các hạt nano bên trong tế bào có thể được theo dõi bằng phương pháp phân tích tế bào chảy và xác nhận bằng vi kính trường tối. Cách tiếp cận này có thể giúp đáp ứng một nhu cầu quan trọng của cộng đồng khoa học trong việc đánh giá mối quan hệ giữa liều lượng hạt nano và độc tính tế bào. Những thí nghiệm như vậy có thể được thực hiện nhanh chóng và dễ dàng hơn bằng cách sử dụng máy phân tích tế bào chảy để đo lường cả sự hấp thụ hạt nano và sức khỏe tế bào. Được xuất bản năm 2010 bởi Wiley‐Liss, Inc.\u003C\u002Fjats:p>","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Evaluation of the potential hazard of man‐made nanomaterials has been hampered by a limited ability to observe and measure nanoparticles in cells. In this study, different concentrations of TiO\u003Cjats:sub>2\u003C\u002Fjats:sub> nanoparticles were suspended in cell culture medium. The suspension was then sonicated and characterized by dynamic light scattering and microscopy. Cultured human‐derived retinal pigment epithelial cells (ARPE‐19) were incubated with TiO\u003Cjats:sub>2\u003C\u002Fjats:sub> nanoparticles at 0, 0.1, 0.3, 1, 3, 10, and 30 μg\u002Fml for 24 hours. Cellular reactions to nanoparticles were evaluated using flow cytometry and dark field microscopy. A FACSCalibur™ flow cytometer was used to measure changes in light scatter after nanoparticle incubation. Both the side scatter and forward scatter changed substantially in response to the TiO\u003Cjats:sub>2\u003C\u002Fjats:sub>. From 0.1 to 30 μg\u002Fml TiO\u003Cjats:sub>2\u003C\u002Fjats:sub>, the side scatter increased sequentially while the forward scatter decreased, presumably due to substantial light reflection by the TiO\u003Cjats:sub>2\u003C\u002Fjats:sub> particles. Based on the parameters of morphology and the calcein‐AM\u002Fpropidium iodide viability assay, TiO\u003Cjats:sub>2\u003C\u002Fjats:sub> concentrations below 30 μg\u002Fml TiO\u003Cjats:sub>2\u003C\u002Fjats:sub> caused minimal cytotoxicity. Microscopic analysis was done on the same cells using an E‐800 Nikon microscope containing a xenon light source and special dark field objectives. At the lowest concentrations of TiO\u003Cjats:sub>2\u003C\u002Fjats:sub> (0.1–0.3 μg\u002Fml), the flow cytometer could detect as few as 5–10 nanoparticles per cell due to intense light scattering by TiO\u003Cjats:sub>2\u003C\u002Fjats:sub>. Rings of concentrated nanoparticles were observed around the nuclei in the vicinity of the endoplasmic reticulum at higher concentrations. These data suggest that the uptake of nanoparticles within cells can be monitored with flow cytometry and confirmed by dark field microscopy. This approach may help fulfill a critical need for the scientific community to assess the relationship between nanoparticle dose and cellular toxicity Such experiments could potentially be performed more quickly and easily using the flow cytometer to measure both nanoparticle uptake and cellular health. Published 2010 Wiley‐Liss, Inc.\u003C\u002Fjats:p>",{"VI":1137,"EN":1138},"Phát hiện hạt nano TiO\u003Csub>2\u003C\u002Fsub> trong tế bào bằng phương pháp phân tích tế bào chảy","Detection of TiO\u003Csub>2\u003C\u002Fsub> nanoparticles in cells by flow cytometry",{"VOID":1140},"20564539",{"VOID":1142},"10.1002\u002Fcyto.a.20927",[143],[304],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcyto.a.20927",[1147,1168,1187,1202,1219],{"id":1148,"sortIndex":390,"researcher":24,"roles":1149,"affiliations":1150,"properties":1161},"26b28d45-1e71-48d9-94af-6a49f5efebe5",[],[1151],{"id":1152,"sortIndex":25,"affiliation":1153,"properties":24},"10f132f6-7ff9-4f1c-84cf-09fc32f14b1f",{"id":1154,"createTime":1155,"updateTime":1155,"relativeEntities":1156,"slug":1157,"properties":1158,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"d68c1ca4-d042-4095-a59c-86f2b4e97744","2024-10-05T00:39:47.409+00:00",[],"Toxicology-Assessment-Division-MD-67-National-Health-and-Environmental-Effects-Research-Laboratory-Office-of-Research-and-Development-US-Environmental-Protection-Agency-Research-Triangle-Park-North-Carolina-27711",{"title":1159},{"EN":1160},"Toxicology Assessment Division (MD-67), National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711",{"openalex":1162,"orcid":1164,"title":1166},{"VOID":1163},"A5084882145",{"VOID":1165},"https:\u002F\u002Forcid.org\u002F0000-0002-3598-0032",{"EN":1167},"William K. Boyes",{"id":1169,"sortIndex":148,"researcher":24,"roles":1170,"affiliations":1171,"properties":1182},"292420b2-a51d-4229-a6bf-fb9a122b750a",[],[1172],{"id":1173,"sortIndex":25,"affiliation":1174,"properties":24},"2728f65f-242b-4a3c-8892-109682753010",{"id":1175,"createTime":1176,"updateTime":1176,"relativeEntities":1177,"slug":1178,"properties":1179,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"aa8e3115-2a37-4df9-af09-b24ea6216461","2024-10-05T00:39:47.423+00:00",[],"Intergrated-Systems-Toxicology-Division-Toxicology-Assessment-Division-MD-67-National-Health-and-Environmental-Effects-Research-Laboratory-Office-of-Research-and-Development-U-S-Environmental-Protection-Agency-Research-Triangle-Park-North-Carolina-27711",{"title":1180},{"EN":1181},"Intergrated Systems Toxicology Division, Toxicology Assessment Division (MD-67), National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711",{"openalex":1183,"title":1185},{"VOID":1184},"A5002706685",{"EN":1186},"Edward J. Massaro",{"id":1188,"sortIndex":408,"researcher":24,"roles":1189,"affiliations":1190,"properties":1197},"7a85ae90-76dd-48f9-9c8d-2fcf5de9db2d",[],[1191],{"id":1192,"sortIndex":25,"affiliation":1193,"properties":24},"45a77c34-0aeb-4337-9bb5-916da8af912c",{"id":1154,"createTime":1155,"updateTime":1155,"relativeEntities":1194,"slug":1157,"properties":1195,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1196},{"EN":1160},{"openalex":1198,"title":1200},{"VOID":1199},"A5033591740",{"EN":1201},"Laura L. Degn",{"id":1203,"sortIndex":309,"researcher":24,"roles":1204,"affiliations":1205,"properties":1212},"82439a0c-c039-4ec2-a52b-43179f06eeb8",[],[1206],{"id":1207,"sortIndex":25,"affiliation":1208,"properties":24},"0208c353-dd0d-4aa0-a1aa-a617a714e432",{"id":1154,"createTime":1155,"updateTime":1155,"relativeEntities":1209,"slug":1157,"properties":1210,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1211},{"EN":1160},{"openalex":1213,"orcid":1215,"title":1217},{"VOID":1214},"A5073169144",{"VOID":1216},"https:\u002F\u002Forcid.org\u002F0000-0002-9326-427X",{"EN":1218},"Kristen M. Sanders",{"id":1220,"sortIndex":25,"researcher":24,"roles":1221,"affiliations":1222,"properties":1229},"1490ffee-767a-4e75-93a1-d1e7db68e299",[],[1223],{"id":1224,"sortIndex":25,"affiliation":1225,"properties":24},"7ac447d8-8cfb-4c44-8912-d956d1bc3ab6",{"id":1154,"createTime":1155,"updateTime":1155,"relativeEntities":1226,"slug":1157,"properties":1227,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1228},{"EN":1160},{"openalex":1230,"orcid":1232,"title":1234},{"VOID":1231},"A5065326123",{"VOID":1233},"https:\u002F\u002Forcid.org\u002F0000-0002-6602-8706",{"EN":1235},"Robert M. Zucker",{"url":24,"publisher":1237,"properties":1262},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1238,"slug":10,"properties":1239,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1245,"manageAffiliations":1246,"indexDatabases":1247,"url":115,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1240,"issn":1241,"introduce":1242,"eissn":1243,"title":1244},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1248,1255],{"id":96,"indexDatabase":1249,"url":111,"indexYears":24,"academicFieldIds":1254,"indexDatabaseRanking":24},{"id":98,"createTime":99,"updateTime":100,"relativeEntities":1250,"label":1251,"description":1252,"key":107,"publicationTags":1253,"standard":24},[],{"EN":103,"VI":103},{"VI":105,"EN":106},[109,110],[113,114],{"id":75,"indexDatabase":1256,"url":88,"indexYears":89,"academicFieldIds":1261,"indexDatabaseRanking":94},{"id":77,"createTime":78,"updateTime":79,"relativeEntities":1257,"label":1258,"description":1259,"key":85,"publicationTags":1260,"standard":24},[],{"EN":82,"VI":82},{"EN":82,"VI":84},[87],[91,92,93],{"volume":1263,"pages":1265,"issue":1267},{"VOID":1264},"77A",{"VOID":1266},"677-685",{"VOID":1008},219,{"total":1268,"publishYear":24,"statisticByYear":1270},{"2012":767,"2013":514,"2014":519,"2015":770,"2016":1012,"2017":1271,"2018":769,"2019":514,"2020":769,"2021":1012,"2022":771,"2023":519,"2024":428},29,"2010-07-01",2010,[1275,1278,1281,1284,1287,1290,1293,1296,1299,1302,1305,1308,1311,1314,1317,1320,1323,1326,1329,1332,1335,1338,1341,1344,1347,1350,1353,1356,1359,1362,1365,1368,1371,1374,1377,1380,1383,1386,1389,1392,1395,1398,1401,1404,1407,1410,1413,1416,1419,1422,1425,1428,1431,1434,1437],{"id":24,"text":1276,"url":24,"identifiers":1277},"10.1038\u002F444267a",{"doi":1276},{"id":24,"text":1279,"url":24,"identifiers":1280},"10.1289\u002Fehp.10327",{"doi":1279},{"id":24,"text":1282,"url":24,"identifiers":1283},"U.S. Environmental Protection Agency, 2007, Nanotechnology white paper",{},{"id":24,"text":1285,"url":24,"identifiers":1286},"U.S. Environmental Protection Agency, 2009, Nanomaterial research strategy",{},{"id":24,"text":1288,"url":24,"identifiers":1289},"10.1038\u002Fnnano.2009.242",{"doi":1288},{"id":24,"text":1291,"url":24,"identifiers":1292},"10.1080\u002F10408440601177780",{"doi":1291},{"id":24,"text":1294,"url":24,"identifiers":1295},"10.1002\u002Fjemt.20847",{"doi":1294},{"id":24,"text":1297,"url":24,"identifiers":1298},"10.1016\u002Fj.aanat.2008.11.001",{"doi":1297},{"id":24,"text":1300,"url":24,"identifiers":1301},"10.1007\u002Fs00216-009-3360-1",{"doi":1300},{"id":24,"text":1303,"url":24,"identifiers":1304},"10.1016\u002Fj.lfs.2009.02.030",{"doi":1303},{"id":24,"text":1306,"url":24,"identifiers":1307},"10.1016\u002Fj.ejpb.2009.09.005",{"doi":1306},{"id":24,"text":1309,"url":24,"identifiers":1310},"U.S. Environmental Protection Agency, 2009, Nanomaterial case studies: Nanoscale titanium dioxide (external review draft)",{},{"id":24,"text":1312,"url":24,"identifiers":1313},"10.1002\u002F0471142956.cy0113s09",{"doi":1312},{"id":24,"text":1315,"url":24,"identifiers":1316},"10.1002\u002Fcyto.a.20242",{"doi":1315},{"id":24,"text":1318,"url":24,"identifiers":1319},"Fujishima A, 1999, TiO2 Photocatalysis Fundamentals and Applications",{},{"id":24,"text":1321,"url":24,"identifiers":1322},"10.1016\u002FS0887-2333(02)00041-3",{"doi":1321},{"id":24,"text":1324,"url":24,"identifiers":1325},"Weast RC, 1984, Handbook of Chemistry and Physics",{},{"id":24,"text":1327,"url":24,"identifiers":1328},"10.1080\u002F10934520903263231",{"doi":1327},{"id":24,"text":1330,"url":24,"identifiers":1331},"Hackley VA, 2001, The use of nomenclature in dispersion science and technology, 960",{},{"id":24,"text":1333,"url":24,"identifiers":1334},"10.1117\u002F1.2737351",{"doi":1333},{"id":24,"text":1336,"url":24,"identifiers":1337},"Shapiro HM, 2003",{},{"id":24,"text":1339,"url":24,"identifiers":1340},"10.1016\u002FS0091-679X(01)63009-7",{"doi":1339},{"id":24,"text":1342,"url":24,"identifiers":1343},"10.1002\u002Fcyto.a.10115",{"doi":1342},{"id":24,"text":1345,"url":24,"identifiers":1346},"10.1002\u002Fcyto.990090307",{"doi":1345},{"id":24,"text":1348,"url":24,"identifiers":1349},"10.1002\u002Fcyto.990100310",{"doi":1348},{"id":24,"text":1351,"url":24,"identifiers":1352},"10.1002\u002Fcyto.990200106",{"doi":1351},{"id":24,"text":1354,"url":24,"identifiers":1355},"10.1021\u002Fes0625632",{"doi":1354},{"id":24,"text":1357,"url":24,"identifiers":1358},"10.1002\u002Fcyto.990130108",{"doi":1357},{"id":24,"text":1360,"url":24,"identifiers":1361},"10.1095\u002Fbiolreprod39.1.157",{"doi":1360},{"id":24,"text":1363,"url":24,"identifiers":1364},"10.1016\u002F0014-4827(89)90300-5",{"doi":1363},{"id":24,"text":1366,"url":24,"identifiers":1367},"10.1016\u002FS0091-679X(08)61730-6",{"doi":1366},{"id":24,"text":1369,"url":24,"identifiers":1370},"10.1002\u002Fcyto.990050518",{"doi":1369},{"id":24,"text":1372,"url":24,"identifiers":1373},"10.1016\u002Fj.taap.2009.09.021",{"doi":1372},{"id":24,"text":1375,"url":24,"identifiers":1376},"10.1002\u002Fcyto.990110712",{"doi":1375},{"id":24,"text":1378,"url":24,"identifiers":1379},"10.1007\u002F4243_2008_047",{"doi":1378},{"id":24,"text":1381,"url":24,"identifiers":1382},"10.1002\u002Fjbio.200910039",{"doi":1381},{"id":24,"text":1384,"url":24,"identifiers":1385},"10.1021\u002Fnl062795z",{"doi":1384},{"id":24,"text":1387,"url":24,"identifiers":1388},"10.2217\u002F17435889.2.5.681",{"doi":1387},{"id":24,"text":1390,"url":24,"identifiers":1391},"10.1039\u002Fb606090k",{"doi":1390},{"id":24,"text":1393,"url":24,"identifiers":1394},"10.1016\u002Fj.cbpa.2005.08.021",{"doi":1393},{"id":24,"text":1396,"url":24,"identifiers":1397},"10.1021\u002Fjp057170o",{"doi":1396},{"id":24,"text":1399,"url":24,"identifiers":1400},"10.1002\u002Fcyto.a.20886",{"doi":1399},{"id":24,"text":1402,"url":24,"identifiers":1403},"10.1002\u002Fcyto.a.20846",{"doi":1402},{"id":24,"text":1405,"url":24,"identifiers":1406},"10.1002\u002Fcyto.a.20833",{"doi":1405},{"id":24,"text":1408,"url":24,"identifiers":1409},"10.1002\u002Fcyto.a.20706",{"doi":1408},{"id":24,"text":1411,"url":24,"identifiers":1412},"10.1002\u002Fcyto.a.20520",{"doi":1411},{"id":24,"text":1414,"url":24,"identifiers":1415},"10.1002\u002F(SICI)1097-0320(19980701)32:3\u003C191::AID-CYTO5>3.0.CO;2-N",{"doi":1414},{"id":24,"text":1417,"url":24,"identifiers":1418},"10.1002\u002Fcyto.a.20891",{"doi":1417},{"id":24,"text":1420,"url":24,"identifiers":1421},"10.1002\u002Fcyto.a.20677",{"doi":1420},{"id":24,"text":1423,"url":24,"identifiers":1424},"10.1002\u002Fcyto.a.20587",{"doi":1423},{"id":24,"text":1426,"url":24,"identifiers":1427},"10.1002\u002F1097-0320(20001201)41:4\u003C298::AID-CYTO8>3.0.CO;2-0",{"doi":1426},{"id":24,"text":1429,"url":24,"identifiers":1430},"10.1002\u002Fcyto.a.20384",{"doi":1429},{"id":24,"text":1432,"url":24,"identifiers":1433},"10.1002\u002Fcyto.a.20889",{"doi":1432},{"id":24,"text":1435,"url":24,"identifiers":1436},"10.1002\u002Fbiot.200800358",{"doi":1435},{"id":24,"text":1438,"url":24,"identifiers":1439},"10.1016\u002Fj.tox.2007.12.022",{"doi":1438},{"id":1441,"createTime":1442,"updateTime":1443,"relativeEntities":1444,"slug":1445,"properties":1446,"entityType":139,"verifyStatus":140,"verifyTime":1462,"verifyNote":141,"syncStatus":23,"languages":1463,"translateLanguages":1464,"viewCount":25,"primaryUrl":1465,"fullTextUrl":24,"authors":1466,"publicationType":184,"publisherRelationship":1510,"citationCount":1542,"citationInfo":1543,"publishDate":1550,"publishYear":1551,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1552,"isForceReanalyzing":278},"0481ccab-6aac-46f3-a724-0ef065b20baf","2024-10-10T01:08:04.897+00:00","2025-02-03T18:51:27.285+00:00",[],"From-truly-na%C3%AFve-to-exhausted-senescent-T-cells-When-markers-predict-functionality",{"mag":1447,"keywords":1449,"openalex":1450,"abstract":1452,"title":1455,"pm":1458,"doi":1460},{"VOID":1448},"1721778868",{"VI":289},{"VOID":1451},"W1721778868",{"VI":1453,"EN":1454},"Nghiên cứu sinh học T tế bào đã được tăng tốc nhờ những tiến bộ đáng kể ở cấp độ công nghệ, đặc biệt là thông qua sự phát triển không ngừng của cytometric dòng chảy. Phương pháp tiếp cận truyền thống để quan sát T tế bào là phân loại chúng thành T giúp đỡ hoặc T tiêu diệt quá đơn giản và không cho phép các nhà nghiên cứu xác định rõ các cơ chế miễn dịch hoặc những thay đổi trong các quá trình sinh lý tác động đến kết quả lâm sàng. Sự phức tạp của các dưới quần thể T tế bào, như chúng ta hiểu ngày nay, kết hợp với sự đa dạng miễn dịch và chức năng của các phân nhóm này tạo ra những khó khăn đáng kể cho việc nghiên cứu sinh học T tế bào. Trong bài viết này, chúng tôi xem xét việc sử dụng các dấu ấn cổ điển trong việc phân định các dưới quần thể T tế bào, từ các tế bào T “naive thật sự” (các tế bào mới rời bỏ tuyến ức không có lịch sử phát triển) đến các tế bào T “lão hóa kiệt sức” (các tế bào phát triển kém thể hiện các bất thường chức năng nghiêm trọng) mà các kiểu hình khác nhau của những quần thể này phản ánh chức năng khác nhau của chúng. Ngoài ra, vì các nhiễm trùng dai dẳng và sự lão hóa theo thời gian đã được chứng minh là có liên quan đến những thay đổi đáng kể trong sự phân bố và chức năng của T tế bào ở người, chúng tôi cũng thảo luận về những thay đổi liên quan đến độ tuổi và do virus cytomegalovirus gây ra trong sự biểu hiện của các dấu ấn phân nhóm chính.","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>The study of T cell biology has been accelerated by substantial progress at the technological level, particularly through the continuing advancement of flow cytometry. The conventional approach of observing T cells as either T helper or T cytotoxic is overly simplistic and does not allow investigators to clearly identify immune mechanisms or alterations in physiological processes that impact on clinical outcomes. The complexity of T cell sub‐populations, as we understand them today, combined with the immunological and functional diversity of these subsets represent significant complications for the study of T cell biology. In this article, we review the use of classical markers in delineating T cell sub‐populations, from “truly naïve” T cells (recent thymic emigrants with no proliferative history) to “exhausted senescent” T cells (poorly proliferative cells that display severe functional abnormalities) wherein the different phenotypes of these populations reflect their disparate functionalities. In addition, since persistent infections and chronological aging have been shown to be associated with significant alterations in human T cell distribution and function, we also discuss age‐associated and cytomegalovirus‐driven alterations in the expression of key subset markers. © 2013 International Society for Advancement of Cytometry\u003C\u002Fjats:p>",{"VI":1456,"EN":1457},"Từ “naive thật sự” đến “T tế bào lão hóa kiệt sức”: Khi các dấu ấn dự đoán chức năng","From “truly naïve” to “exhausted senescent” T cells: When markers predict functionality",{"VOID":1459},"24124072",{"VOID":1461},"10.1002\u002Fcyto.a.22351","2024-10-10T01:08:04.896+00:00",[143],[304],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcyto.a.22351",[1467,1488],{"id":1468,"sortIndex":148,"researcher":24,"roles":1469,"affiliations":1470,"properties":1481},"0c45a261-1f05-4e5c-9525-92881fab5464",[],[1471],{"id":1472,"sortIndex":25,"affiliation":1473,"properties":24},"02351ca2-71ad-4cc4-b06e-ecbb8cc3008d",{"id":1474,"createTime":1475,"updateTime":1475,"relativeEntities":1476,"slug":1477,"properties":1478,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"1e3feca1-582a-4834-a558-e467f48fbfc5","2024-10-10T01:08:04.928+00:00",[],"Department-of-Medicine-Geriatrics-Division-Research-Center-on-Aging-University-of-Sherbrooke-Sherbrooke-Canada",{"title":1479},{"EN":1480},"Department of Medicine Geriatrics Division Research Center on Aging University of Sherbrooke Sherbrooke Canada",{"openalex":1482,"orcid":1484,"title":1486},{"VOID":1483},"A5043056372",{"VOID":1485},"https:\u002F\u002Forcid.org\u002F0000-0001-5835-7449",{"EN":1487},"Tamàs Fülöp",{"id":1489,"sortIndex":25,"researcher":24,"roles":1490,"affiliations":1491,"properties":1503},"bfadc3ab-d85c-4e26-97e8-c92690a4623d",[],[1492],{"id":1493,"sortIndex":25,"affiliation":1494,"properties":24},"90c9fdf3-8225-4cb0-838c-da19ab68b66f",{"id":1495,"createTime":1496,"updateTime":1497,"relativeEntities":1498,"slug":1499,"properties":1500,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"fedd43f3-0683-48ac-a004-63b1cd8dcb63","2024-10-08T05:53:51.014+00:00","2024-10-10T01:08:04.916+00:00",[],"Singapore-Immunology-Network-SIgN-Biopolis-Agency-for-Science-Technology-and-Research-A-STAR-Singapore",{"title":1501},{"EN":1502},"Singapore Immunology Network (SIgN), Biopolis, Agency for Science Technology and Research (A*STAR), Singapore",{"openalex":1504,"orcid":1506,"title":1508},{"VOID":1505},"A5031563087",{"VOID":1507},"https:\u002F\u002Forcid.org\u002F0000-0001-8805-5433",{"EN":1509},"Anis Larbi",{"url":24,"publisher":1511,"properties":1536},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1512,"slug":10,"properties":1513,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1519,"manageAffiliations":1520,"indexDatabases":1521,"url":115,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1514,"issn":1515,"introduce":1516,"eissn":1517,"title":1518},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1522,1529],{"id":96,"indexDatabase":1523,"url":111,"indexYears":24,"academicFieldIds":1528,"indexDatabaseRanking":24},{"id":98,"createTime":99,"updateTime":100,"relativeEntities":1524,"label":1525,"description":1526,"key":107,"publicationTags":1527,"standard":24},[],{"EN":103,"VI":103},{"VI":105,"EN":106},[109,110],[113,114],{"id":75,"indexDatabase":1530,"url":88,"indexYears":89,"academicFieldIds":1535,"indexDatabaseRanking":94},{"id":77,"createTime":78,"updateTime":79,"relativeEntities":1531,"label":1532,"description":1533,"key":85,"publicationTags":1534,"standard":24},[],{"EN":82,"VI":82},{"EN":82,"VI":84},[87],[91,92,93],{"volume":1537,"pages":1539,"issue":1541},{"VOID":1538},"85",{"VOID":1540},"25-35",{"VOID":510},286,{"total":1542,"publishYear":24,"statisticByYear":1544},{"2014":390,"2015":1013,"2016":514,"2017":1014,"2018":1545,"2019":1546,"2020":1547,"2021":1546,"2022":1546,"2023":1548,"2024":1549},41,35,43,24,25,"2014-01-01",2014,[1553,1556,1558,1561,1564,1567,1570,1573,1576,1579,1582,1585,1588,1591,1594,1597,1600,1603,1606,1609,1612,1615,1618,1621,1624,1627,1630,1633,1636,1639,1642,1645,1648,1651,1654,1657,1660,1663,1666,1669,1672,1675,1678,1681,1684,1687,1690,1693,1696,1699,1702,1705,1708,1711,1714,1717,1720,1723,1726,1729,1732,1735,1738,1741,1744,1747,1750,1753,1756,1759,1762,1765,1768,1771,1774,1777,1780,1783],{"id":24,"text":1554,"url":24,"identifiers":1555},"10.1097\u002FCJI.0b013e31827806e6",{"doi":1554},{"id":24,"text":779,"url":24,"identifiers":1557},{"doi":779},{"id":24,"text":1559,"url":24,"identifiers":1560},"10.1186\u002Fcc10333",{"doi":1559},{"id":24,"text":1562,"url":24,"identifiers":1563},"10.1146\u002Fannurev.immunol.22.012703.104702",{"doi":1562},{"id":24,"text":1565,"url":24,"identifiers":1566},"10.1038\u002Fnm0402-379",{"doi":1565},{"id":24,"text":1568,"url":24,"identifiers":1569},"10.1128\u002FJVI.79.6.3675-3683.2005",{"doi":1568},{"id":24,"text":1571,"url":24,"identifiers":1572},"10.1111\u002Fj.1365-2249.2008.03785.x",{"doi":1571},{"id":24,"text":1574,"url":24,"identifiers":1575},"10.1016\u002Fj.smim.2004.02.007",{"doi":1574},{"id":24,"text":1577,"url":24,"identifiers":1578},"10.4049\u002Fjimmunol.175.12.8218",{"doi":1577},{"id":24,"text":1580,"url":24,"identifiers":1581},"10.1128\u002FJVI.75.12.5550-5558.2001",{"doi":1580},{"id":24,"text":1583,"url":24,"identifiers":1584},"Méndez‐Lagares G, 2012, Specific patterns of CD4‐associated immunosenescence in vertically HIV‐infected subjects, Clin Microbiol Infect",{},{"id":24,"text":1586,"url":24,"identifiers":1587},"10.1128\u002FJVI.01262-06",{"doi":1586},{"id":24,"text":1589,"url":24,"identifiers":1590},"10.1016\u002Fj.mad.2005.11.001",{"doi":1589},{"id":24,"text":1592,"url":24,"identifiers":1593},"10.1016\u002Fj.immuni.2008.11.002",{"doi":1592},{"id":24,"text":1595,"url":24,"identifiers":1596},"10.1016\u002Fj.immuni.2012.09.020",{"doi":1595},{"id":24,"text":1598,"url":24,"identifiers":1599},"10.1186\u002F1742-4933-9-23",{"doi":1598},{"id":24,"text":1601,"url":24,"identifiers":1602},"10.1186\u002F1742-4933-9-15",{"doi":1601},{"id":24,"text":1604,"url":24,"identifiers":1605},"10.1111\u002Fj.1365-2249.2012.04643.x",{"doi":1604},{"id":24,"text":1607,"url":24,"identifiers":1608},"10.1016\u002Fj.ymgme.2012.09.018",{"doi":1607},{"id":24,"text":1610,"url":24,"identifiers":1611},"10.1002\u002Feji.200636976",{"doi":1610},{"id":24,"text":1613,"url":24,"identifiers":1614},"10.1152\u002Fjapplphysiol.00601.2010",{"doi":1613},{"id":24,"text":1616,"url":24,"identifiers":1617},"10.1084\u002Fjem.20011756",{"doi":1616},{"id":24,"text":1619,"url":24,"identifiers":1620},"10.4049\u002Fjimmunol.177.11.7802",{"doi":1619},{"id":24,"text":1622,"url":24,"identifiers":1623},"10.1189\u002Fjlb.0209086",{"doi":1622},{"id":24,"text":1625,"url":24,"identifiers":1626},"10.1111\u002Fimm.12074",{"doi":1625},{"id":24,"text":1628,"url":24,"identifiers":1629},"10.1038\u002Fnri2318",{"doi":1628},{"id":24,"text":1631,"url":24,"identifiers":1632},"10.1074\u002Fmcp.M110.003921",{"doi":1631},{"id":24,"text":1634,"url":24,"identifiers":1635},"10.1038\u002Fni.2547",{"doi":1634},{"id":24,"text":1637,"url":24,"identifiers":1638},"10.1084\u002Fjem.20050882",{"doi":1637},{"id":24,"text":1640,"url":24,"identifiers":1641},"10.1126\u002Fscitranslmed.3004754",{"doi":1640},{"id":24,"text":1643,"url":24,"identifiers":1644},"10.1371\u002Fjournal.ppat.1003076",{"doi":1643},{"id":24,"text":1646,"url":24,"identifiers":1647},"10.1158\u002F1078-0432.CCR-11-2630",{"doi":1646},{"id":24,"text":1649,"url":24,"identifiers":1650},"10.1016\u002Fj.exger.2003.11.016",{"doi":1649},{"id":24,"text":1652,"url":24,"identifiers":1653},"10.1371\u002Fjournal.pone.0046073",{"doi":1652},{"id":24,"text":1655,"url":24,"identifiers":1656},"10.1016\u002F0198-8859(84)90006-5",{"doi":1655},{"id":24,"text":1658,"url":24,"identifiers":1659},"10.1016\u002F0014-4827(61)90192-6",{"doi":1658},{"id":24,"text":1661,"url":24,"identifiers":1662},"10.1016\u002Fj.exger.2010.08.027",{"doi":1661},{"id":24,"text":1664,"url":24,"identifiers":1665},"10.4049\u002Fjimmunol.1102889",{"doi":1664},{"id":24,"text":1667,"url":24,"identifiers":1668},"10.1016\u002Fj.smim.2012.12.005",{"doi":1667},{"id":24,"text":1670,"url":24,"identifiers":1671},"10.1016\u002Fj.coi.2012.04.001",{"doi":1670},{"id":24,"text":1673,"url":24,"identifiers":1674},"10.4049\u002Fjimmunol.1100978",{"doi":1673},{"id":24,"text":1676,"url":24,"identifiers":1677},"10.1007\u002Fs11357-012-9381-2",{"doi":1676},{"id":24,"text":1679,"url":24,"identifiers":1680},"10.1182\u002Fblood-2009-01-199588",{"doi":1679},{"id":24,"text":1682,"url":24,"identifiers":1683},"10.1002\u002Fijc.27410",{"doi":1682},{"id":24,"text":1685,"url":24,"identifiers":1686},"10.1146\u002Fannurev-physiol-030212-183653",{"doi":1685},{"id":24,"text":1688,"url":24,"identifiers":1689},"10.1038\u002Fnri2959",{"doi":1688},{"id":24,"text":1691,"url":24,"identifiers":1692},"10.2217\u002Fahe.12.78",{"doi":1691},{"id":24,"text":1694,"url":24,"identifiers":1695},"10.1016\u002Fj.arr.2010.09.008",{"doi":1694},{"id":24,"text":1697,"url":24,"identifiers":1698},"10.1038\u002Fni1033",{"doi":1697},{"id":24,"text":1700,"url":24,"identifiers":1701},"10.1016\u002Fj.arr.2010.08.003",{"doi":1700},{"id":24,"text":1703,"url":24,"identifiers":1704},"10.1016\u002FS0047-6374(03)00026-5",{"doi":1703},{"id":24,"text":1706,"url":24,"identifiers":1707},"10.1023\u002FA:1006611518223",{"doi":1706},{"id":24,"text":1709,"url":24,"identifiers":1710},"10.1016\u002Fj.immuni.2012.02.006",{"doi":1709},{"id":24,"text":1712,"url":24,"identifiers":1713},"10.1002\u002Feji.200838250",{"doi":1712},{"id":24,"text":1715,"url":24,"identifiers":1716},"10.4049\u002Fjimmunol.175.2.755",{"doi":1715},{"id":24,"text":1718,"url":24,"identifiers":1719},"10.1111\u002Fj.1749-6632.2000.tb06651.x",{"doi":1718},{"id":24,"text":1721,"url":24,"identifiers":1722},"10.1196\u002Fannals.1329.016",{"doi":1721},{"id":24,"text":1724,"url":24,"identifiers":1725},"10.1007\u002Fs11357-010-9170-8",{"doi":1724},{"id":24,"text":1727,"url":24,"identifiers":1728},"10.1128\u002FJVI.02565-09",{"doi":1727},{"id":24,"text":1730,"url":24,"identifiers":1731},"10.1097\u002FAOG.0b013e3181e00927",{"doi":1730},{"id":24,"text":1733,"url":24,"identifiers":1734},"10.1023\u002FB:JOCI.0000019777.75784.6f",{"doi":1733},{"id":24,"text":1736,"url":24,"identifiers":1737},"10.1016\u002Fj.it.2010.12.006",{"doi":1736},{"id":24,"text":1739,"url":24,"identifiers":1740},"10.1146\u002Fannurev-med-042909-093756",{"doi":1739},{"id":24,"text":1742,"url":24,"identifiers":1743},"10.1002\u002Fpath.2276",{"doi":1742},{"id":24,"text":1745,"url":24,"identifiers":1746},"10.1016\u002Fj.cca.2012.11.025",{"doi":1745},{"id":24,"text":1748,"url":24,"identifiers":1749},"10.4049\u002Fjimmunol.169.4.1984",{"doi":1748},{"id":24,"text":1751,"url":24,"identifiers":1752},"10.1371\u002Fjournal.pone.0016103",{"doi":1751},{"id":24,"text":1754,"url":24,"identifiers":1755},"10.1016\u002Fj.coi.2012.04.002",{"doi":1754},{"id":24,"text":1757,"url":24,"identifiers":1758},"10.1111\u002Fj.1749-6632.2011.06297.x",{"doi":1757},{"id":24,"text":1760,"url":24,"identifiers":1761},"10.1111\u002Fj.1474-9726.2012.00849.x",{"doi":1760},{"id":24,"text":1763,"url":24,"identifiers":1764},"10.1016\u002Fj.intimp.2012.10.019",{"doi":1763},{"id":24,"text":1766,"url":24,"identifiers":1767},"10.1038\u002Fnature05115",{"doi":1766},{"id":24,"text":1769,"url":24,"identifiers":1770},"10.1007\u002Fs11357-010-9200-6",{"doi":1769},{"id":24,"text":1772,"url":24,"identifiers":1773},"10.1016\u002Fj.aller.2011.01.002",{"doi":1772},{"id":24,"text":1775,"url":24,"identifiers":1776},"10.1189\u002Fjlb.0912438",{"doi":1775},{"id":24,"text":1778,"url":24,"identifiers":1779},"10.1128\u002FCVI.00455-09",{"doi":1778},{"id":24,"text":1781,"url":24,"identifiers":1782},"10.1002\u002Fcyto.a.20643",{"doi":1781},{"id":24,"text":1784,"url":24,"identifiers":1785},"10.1016\u002Fj.immuni.2012.01.002",{"doi":1784},{"id":1787,"createTime":1788,"updateTime":1789,"relativeEntities":1790,"slug":1791,"properties":1792,"entityType":139,"verifyStatus":140,"verifyTime":1788,"verifyNote":141,"syncStatus":23,"languages":1808,"translateLanguages":1809,"viewCount":25,"primaryUrl":1810,"fullTextUrl":24,"authors":1811,"publicationType":184,"publisherRelationship":1848,"citationCount":1881,"citationInfo":1882,"publishDate":1886,"publishYear":1887,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1888,"isForceReanalyzing":278},"a94de4f4-7b04-4c0f-95b7-b54b014d697b","2024-09-20T06:51:37.631+00:00","2025-02-03T18:50:30.287+00:00",[],"Flow-cytometry-controls-instrument-setup-and-the-determination-of-positivity",{"mag":1793,"keywords":1795,"openalex":1796,"abstract":1798,"title":1801,"pm":1804,"doi":1806},{"VOID":1794},"2066972199",{"VI":289},{"VOID":1797},"W2066972199",{"VI":1799,"EN":1800},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Một mục tiêu thường gặp trong phân tích dòng tế bào là phân loại tế bào thành dương tính hoặc âm tính với một đánh dấu cụ thể, hoặc xác định tỷ lệ chính xác giữa tế bào dương tính và âm tính. Điều này đòi hỏi thiết lập máy móc tốt và có thể tái tạo, cũng như việc sử dụng cẩn thận các đối chứng để phân tích và diễn giải dữ liệu. Loại đối chứng nào nên bao gồm trong các loại thí nghiệm dòng tế bào khác nhau là một vấn đề đang được tranh luận và thảo luận. Trong hướng dẫn này, chúng tôi phân loại các đối chứng thành các danh mục khác nhau, mô tả các tùy chọn trong mỗi danh mục, và thảo luận về lợi ích của từng tùy chọn. © 2006 Hiệp hội Quốc tế về Cytology Phân tích\u003C\u002Fjats:p>","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>A frequent goal of flow cytometric analysis is to classify cells as positive or negative for a given marker, or to determine the precise ratio of positive to negative cells. This requires good and reproducible instrument setup, and careful use of controls for analyzing and interpreting the data. The type of controls to include in various kinds of flow cytometry experiments is a matter of some debate and discussion. In this tutorial, we classify controls in various categories, describe the options within each category, and discuss the merits of each option. © 2006 International Society for Analytical Cytology\u003C\u002Fjats:p>",{"VI":1802,"EN":1803},"Kiểm soát trong phân tích dòng tế bào, thiết lập thiết bị và xác định tính dương tính","Flow cytometry controls, instrument setup, and the determination of positivity",{"VOID":1805},"16888771",{"VOID":1807},"10.1002\u002Fcyto.a.20333",[143],[304],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcyto.a.20333",[1812,1831],{"id":1813,"sortIndex":148,"researcher":24,"roles":1814,"affiliations":1815,"properties":1826},"f292fbae-07c0-4ff0-b898-66ffb6d8c9ff",[],[1816],{"id":1817,"sortIndex":25,"affiliation":1818,"properties":24},"3b034aaf-330d-46c8-9e07-bbb9eb8b5267",{"id":1819,"createTime":1820,"updateTime":1820,"relativeEntities":1821,"slug":1822,"properties":1823,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"e3a005d1-88fe-463e-86c0-6fda20cbabca","2024-09-20T06:51:37.649+00:00",[],"BD-Biosciences-2350-Qume-Drive-San-Jose-California-95131",{"title":1824},{"EN":1825},"BD Biosciences, 2350 Qume Drive, San Jose, California 95131",{"openalex":1827,"title":1829},{"VOID":1828},"A5072021137",{"EN":1830},"Joseph Trotter",{"id":1832,"sortIndex":25,"researcher":24,"roles":1833,"affiliations":1834,"properties":1841},"53ada1e4-bfd8-42b6-b5dc-9632306e61f7",[],[1835],{"id":1836,"sortIndex":25,"affiliation":1837,"properties":24},"69ed95e9-c4e0-476f-a661-19ccd217f2f8",{"id":1819,"createTime":1820,"updateTime":1820,"relativeEntities":1838,"slug":1822,"properties":1839,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1840},{"EN":1825},{"openalex":1842,"orcid":1844,"title":1846},{"VOID":1843},"A5068399737",{"VOID":1845},"https:\u002F\u002Forcid.org\u002F0000-0003-0795-9946",{"EN":1847},"Holden T. Maecker",{"url":24,"publisher":1849,"properties":1874},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1850,"slug":10,"properties":1851,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1857,"manageAffiliations":1858,"indexDatabases":1859,"url":115,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1852,"issn":1853,"introduce":1854,"eissn":1855,"title":1856},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1860,1867],{"id":96,"indexDatabase":1861,"url":111,"indexYears":24,"academicFieldIds":1866,"indexDatabaseRanking":24},{"id":98,"createTime":99,"updateTime":100,"relativeEntities":1862,"label":1863,"description":1864,"key":107,"publicationTags":1865,"standard":24},[],{"EN":103,"VI":103},{"VI":105,"EN":106},[109,110],[113,114],{"id":75,"indexDatabase":1868,"url":88,"indexYears":89,"academicFieldIds":1873,"indexDatabaseRanking":94},{"id":77,"createTime":78,"updateTime":79,"relativeEntities":1869,"label":1870,"description":1871,"key":85,"publicationTags":1872,"standard":24},[],{"EN":82,"VI":82},{"EN":82,"VI":84},[87],[91,92,93],{"volume":1875,"pages":1877,"issue":1879},{"VOID":1876},"69A",{"VOID":1878},"1037-1042",{"VOID":1880},"9",315,{"total":1881,"publishYear":24,"statisticByYear":1883},{"2012":517,"2013":1884,"2014":1885,"2015":517,"2016":1884,"2017":1012,"2018":1014,"2019":1549,"2020":1548,"2021":1546,"2022":1548,"2023":770,"2024":771},20,26,"2006-09-01",2006,[1889,1892,1895,1898,1901,1904],{"id":24,"text":1890,"url":24,"identifiers":1891},"10.1002\u002F(SICI)1097-0320(19981001)33:2\u003C267::AID-CYTO24>3.0.CO;2-R",{"doi":1890},{"id":24,"text":1893,"url":24,"identifiers":1894},"10.1002\u002Fcyto.a.20092",{"doi":1893},{"id":24,"text":1896,"url":24,"identifiers":1897},"10.1002\u002F1097-0320(20011101)45:3\u003C194::AID-CYTO1163>3.0.CO;2-C",{"doi":1896},{"id":24,"text":1899,"url":24,"identifiers":1900},"10.1186\u002F1471-2172-6-13",{"doi":1899},{"id":24,"text":1902,"url":24,"identifiers":1903},"10.1016\u002FS0022-1759(01)00535-X",{"doi":1902},{"id":24,"text":1905,"url":24,"identifiers":1906},"Ghanekar SA, 2005, Manual of Clinical Laboratory Immunology, 353",{},{"id":1908,"createTime":1909,"updateTime":1910,"relativeEntities":1911,"slug":1912,"properties":1913,"entityType":139,"verifyStatus":140,"verifyTime":1930,"verifyNote":141,"syncStatus":23,"languages":1931,"translateLanguages":1932,"viewCount":25,"primaryUrl":1933,"fullTextUrl":24,"authors":1934,"publicationType":184,"publisherRelationship":2006,"citationCount":2038,"citationInfo":2039,"publishDate":2044,"publishYear":1887,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":2045,"isForceReanalyzing":278},"323b732e-0c4e-403b-819c-30d17a6cbab9","2024-10-12T02:28:10.021+00:00","2025-02-03T18:49:32.832+00:00",[],"Spectral-imaging-Principles-and-applications",{"mag":1914,"keywords":1916,"openalex":1918,"abstract":1920,"title":1923,"pm":1926,"doi":1928},{"VOID":1915},"1981105828",{"VI":1917},"Hình ảnh quang phổ, quang phổ học, ứng dụng khoa học, phân tích dữ liệu.",{"VOID":1919},"W1981105828",{"VI":1921,"EN":1922},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Đặt bối cảnh:\u003C\u002Fjats:title>\u003Cjats:p>Hình ảnh quang phổ mở rộng khả năng của các nghiên cứu sinh học và lâm sàng để nghiên cứu đồng thời nhiều đặc điểm như bào quan và protein cả về chất lượng và số lượng. Hình ảnh quang phổ kết hợp hai phương pháp khoa học nổi tiếng, đó là quang phổ và hình ảnh, để cung cấp một công cụ mới có lợi thế. Nhu cầu đo quang phổ tại mỗi điểm của hình ảnh yêu cầu kết hợp quang học phân tán với các thiết bị hình ảnh thông thường hơn, và cũng giới thiệu những hạn chế.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Phương pháp và Kết quả:\u003C\u002Fjats:title>\u003Cjats:p>Các nguyên tắc của hình ảnh quang phổ và một vài ứng dụng tiêu biểu được mô tả. Phân tích hình ảnh quang phổ là cần thiết vì cấu trúc dữ liệu phức tạp không thể được phân tích trực quan. Một vài thuật toán được thảo luận với nhấn mạnh vào việc sử dụng cho các chế độ thí nghiệm khác nhau (huỳnh quang và trường sáng). Cuối cùng, hình ảnh quang phổ, giống như bất kỳ phương pháp nào, cần được đánh giá dựa trên những lợi thế của nó đối với các ứng dụng cụ thể, một số trong đó được mô tả.","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Background:\u003C\u002Fjats:title>\u003Cjats:p>Spectral imaging extends the capabilities of biological and clinical studies to simultaneously study multiple features such as organelles and proteins qualitatively and quantitatively. Spectral imaging combines two well‐known scientific methodologies, namely spectroscopy and imaging, to provide a new advantageous tool. The need to measure the spectrum at each point of the image requires combining dispersive optics with the more common imaging equipment, and introduces constrains as well.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods and Results:\u003C\u002Fjats:title>\u003Cjats:p>The principles of spectral imaging and a few representative applications are described. Spectral imaging analysis is necessary because the complex data structure cannot be analyzed visually. A few of the algorithms are discussed with emphasis on the usage for different experimental modes (fluorescence and bright field). Finally, spectral imaging, like any method, should be evaluated in light of its advantages to specific applications, a selection of which is described.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions:\u003C\u002Fjats:title>\u003Cjats:p>Spectral imaging is a relatively new technique and its full potential is yet to be exploited. Nevertheless, several applications have already shown its potential. © 2006 International Society for Analytical Cytology\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"VI":1924,"EN":1925},"Hình ảnh quang phổ: Nguyên tắc và ứng dụng","Spectral imaging: Principles and applications",{"VOID":1927},"16969819",{"VOID":1929},"10.1002\u002Fcyto.a.20311","2024-10-12T02:28:10.020+00:00",[143],[304],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcyto.a.20311",[1935,1956,1989],{"id":1936,"sortIndex":309,"researcher":24,"roles":1937,"affiliations":1938,"properties":1949},"1c27feee-8d78-4bd5-8db2-1c63693a0262",[],[1939],{"id":1940,"sortIndex":25,"affiliation":1941,"properties":24},"8b16c55a-787d-402d-a8d4-080cf67a992a",{"id":1942,"createTime":1943,"updateTime":1943,"relativeEntities":1944,"slug":1945,"properties":1946,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"5fdddb10-6910-4bf8-b6a5-6c9d91d385db","2024-10-12T02:28:10.054+00:00",[],"Division-of-Cancer-Immunotherapeutics-and-Tumor-Immunology-City-of-Hope-National-Medical-Center-California-USA",{"title":1947},{"EN":1948},"Division of Cancer Immunotherapeutics and Tumor Immunology, City of Hope National Medical Center, California, USA",{"openalex":1950,"orcid":1952,"title":1954},{"VOID":1951},"A5011931021",{"VOID":1953},"https:\u002F\u002Forcid.org\u002F0000-0003-4155-0976",{"EN":1955},"George McNamara",{"id":1957,"sortIndex":25,"researcher":24,"roles":1958,"affiliations":1959,"properties":1982},"aebaea01-e83c-4f29-be47-d11a672041f1",[],[1960,1971],{"id":1961,"sortIndex":25,"affiliation":1962,"properties":24},"ebd3d301-179e-4039-a29d-2ef95c183a66",{"id":1963,"createTime":1964,"updateTime":1965,"relativeEntities":1966,"slug":1967,"properties":1968,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"b136b195-2346-4650-8653-df0a02ee842a","2023-12-06T20:34:28.510+00:00","2024-11-26T22:36:18.561+00:00",[],"Department-of-Physics-Bar-Ilan-University-Ramat-Gan-Israel",{"title":1969},{"VI":1970},"Department of Physics, Bar-Ilan University, Ramat-Gan, Israel",{"id":1972,"sortIndex":148,"affiliation":1973,"properties":24},"2df4874e-7edd-419d-9f37-1bdfb62b3da9",{"id":1974,"createTime":1975,"updateTime":1976,"relativeEntities":1977,"slug":1978,"properties":1979,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"2d394bcc-6fb0-415f-b25f-050e6a80c60c","2023-12-29T13:24:15.023+00:00","2024-10-12T02:28:10.035+00:00",[],"Quantitative-Imaging-Group-Faculty-of-Applied-Sciences-Delft-University-of-Technology-Delft-The-Netherlands",{"title":1980},{"VI":1981},"Quantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands",{"openalex":1983,"orcid":1985,"title":1987},{"VOID":1984},"A5082934579",{"VOID":1986},"https:\u002F\u002Forcid.org\u002F0000-0002-8783-2015",{"EN":1988},"Yuval Garini",{"id":1990,"sortIndex":148,"researcher":24,"roles":1991,"affiliations":1992,"properties":1999},"da6b9ada-e30d-4961-8229-cb0bed378103",[],[1993],{"id":1994,"sortIndex":25,"affiliation":1995,"properties":24},"67607dec-d79d-45fa-8d06-3eba29eed1cb",{"id":1974,"createTime":1975,"updateTime":1976,"relativeEntities":1996,"slug":1978,"properties":1997,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1998},{"VI":1981},{"openalex":2000,"orcid":2002,"title":2004},{"VOID":2001},"A5072691740",{"VOID":2003},"https:\u002F\u002Forcid.org\u002F0000-0002-5575-5174",{"EN":2005},"Ian Young",{"url":24,"publisher":2007,"properties":2032},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2008,"slug":10,"properties":2009,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":2015,"manageAffiliations":2016,"indexDatabases":2017,"url":115,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":2010,"issn":2011,"introduce":2012,"eissn":2013,"title":2014},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[2018,2025],{"id":96,"indexDatabase":2019,"url":111,"indexYears":24,"academicFieldIds":2024,"indexDatabaseRanking":24},{"id":98,"createTime":99,"updateTime":100,"relativeEntities":2020,"label":2021,"description":2022,"key":107,"publicationTags":2023,"standard":24},[],{"EN":103,"VI":103},{"VI":105,"EN":106},[109,110],[113,114],{"id":75,"indexDatabase":2026,"url":88,"indexYears":89,"academicFieldIds":2031,"indexDatabaseRanking":94},{"id":77,"createTime":78,"updateTime":79,"relativeEntities":2027,"label":2028,"description":2029,"key":85,"publicationTags":2030,"standard":24},[],{"EN":82,"VI":82},{"EN":82,"VI":84},[87],[91,92,93],{"volume":2033,"pages":2034,"issue":2036},{"VOID":1876},{"VOID":2035},"735-747",{"VOID":2037},"8",406,{"total":2038,"publishYear":24,"statisticByYear":2040},{"2012":1014,"2013":1015,"2014":1885,"2015":1884,"2016":768,"2017":1885,"2018":1548,"2019":1546,"2020":2041,"2021":1548,"2022":2042,"2023":2043,"2024":1012},37,31,30,"2006-08-01",[2046,2049,2052,2055,2058,2061,2064,2067,2070,2073,2076,2079,2082,2085,2088,2091,2094,2097,2100,2103,2106,2109,2112,2115,2118,2121,2124,2127,2130,2133,2136,2139,2142,2145,2148,2151,2154,2157,2160,2163,2166,2169,2172,2175,2178,2181],{"id":24,"text":2047,"url":24,"identifiers":2048},"10.1046\u002Fj.1365-2818.1998.00290.x",{"doi":2047},{"id":24,"text":2050,"url":24,"identifiers":2051},"Newton I, 1987, Opticks (1704)",{},{"id":24,"text":2053,"url":24,"identifiers":2054},"Voltaire F‐MA, 1738, Éléments de la philosophie de Newton",{},{"id":24,"text":2056,"url":24,"identifiers":2057},"10.1080\u002F14786441308634955",{"doi":2056},{"id":24,"text":2059,"url":24,"identifiers":2060},"10.1103\u002FPhysRev.28.1049",{"doi":2059},{"id":24,"text":2062,"url":24,"identifiers":2063},"10.1002\u002F0470011149",{"doi":2062},{"id":24,"text":2065,"url":24,"identifiers":2066},"Smith E, 2005, Modern Raman Spectroscopy, a Practical Approach",{},{"id":24,"text":2068,"url":24,"identifiers":2069},"10.1364\u002FAO.14.003086",{"doi":2068},{"id":24,"text":2071,"url":24,"identifiers":2072},"10.1088\u002F0026-1394\u002F28\u002F3\u002F008",{"doi":2071},{"id":24,"text":2074,"url":24,"identifiers":2075},"10.1016\u002FS0006-3495(97)78155-4",{"doi":2074},{"id":24,"text":2077,"url":24,"identifiers":2078},"10.1038\u002Fnbt994",{"doi":2077},{"id":24,"text":2080,"url":24,"identifiers":2081},"10.1117\u002F12.381686",{"doi":2080},{"id":24,"text":2083,"url":24,"identifiers":2084},"10.1364\u002FAO.43.002079",{"doi":2083},{"id":24,"text":2086,"url":24,"identifiers":2087},"10.2144\u002F01316bt01",{"doi":2086},{"id":24,"text":2089,"url":24,"identifiers":2090},"10.1002\u002F1361-6374(199606)4:2\u003C65::AID-BIO4>3.0.CO;2-D",{"doi":2089},{"id":24,"text":2092,"url":24,"identifiers":2093},"10.1046\u002Fj.1365-2818.1996.131411.x",{"doi":2092},{"id":24,"text":2095,"url":24,"identifiers":2096},"10.1046\u002Fj.1365-2818.2000.00665.x",{"doi":2095},{"id":24,"text":2098,"url":24,"identifiers":2099},"10.1016\u002FS0014-5793(03)00521-0",{"doi":2098},{"id":24,"text":2101,"url":24,"identifiers":2102},"10.1002\u002Fcyto.a.20048",{"doi":2101},{"id":24,"text":2104,"url":24,"identifiers":2105},"10.1364\u002FAO.36.003694",{"doi":2104},{"id":24,"text":2107,"url":24,"identifiers":2108},"10.1117\u002F1.1583734",{"doi":2107},{"id":24,"text":2110,"url":24,"identifiers":2111},"10.1038\u002Fnbt899",{"doi":2110},{"id":24,"text":2113,"url":24,"identifiers":2114},"10.1109\u002F16.760393",{"doi":2113},{"id":24,"text":2116,"url":24,"identifiers":2117},"10.1002\u002F(SICI)1097-0320(19990301)35:3\u003C214::AID-CYTO4>3.0.CO;2-D",{"doi":2116},{"id":24,"text":2119,"url":24,"identifiers":2120},"10.1111\u002Fj.1365-2818.2004.01262.x",{"doi":2119},{"id":24,"text":2122,"url":24,"identifiers":2123},"Garini Y, 1996, Fluorescence Imaging Spectroscopy and Microscopy, 87",{},{"id":24,"text":2125,"url":24,"identifiers":2126},"Young IT, 1998, The Digital Signal Processing Handbook, 51.1",{},{"id":24,"text":2128,"url":24,"identifiers":2129},"10.1109\u002FTMI.2005.859207",{"doi":2128},{"id":24,"text":2131,"url":24,"identifiers":2132},"10.1007\u002Fb102216",{"doi":2131},{"id":24,"text":2134,"url":24,"identifiers":2135},"10.1117\u002F1.2032458",{"doi":2134},{"id":24,"text":2137,"url":24,"identifiers":2138},"10.1038\u002Fnbt896",{"doi":2137},{"id":24,"text":2140,"url":24,"identifiers":2141},"Lawson CL, 1974, Solving Least Squares Problems",{},{"id":24,"text":2143,"url":24,"identifiers":2144},"Lakowicz JR, 1986, Principles of Fluorescence Spectroscopy, 496",{},{"id":24,"text":2146,"url":24,"identifiers":2147},"10.1118\u002F1.597841",{"doi":2146},{"id":24,"text":2149,"url":24,"identifiers":2150},"10.1177\u002F002215549904701010",{"doi":2149},{"id":24,"text":2152,"url":24,"identifiers":2153},"10.1155\u002F2001\u002F740909",{"doi":2152},{"id":24,"text":2155,"url":24,"identifiers":2156},"Jolliffe IT, 2002, Principle Component Analysis",{},{"id":24,"text":2158,"url":24,"identifiers":2159},"10.1126\u002Fscience.273.5274.494",{"doi":2158},{"id":24,"text":2161,"url":24,"identifiers":2162},"10.1016\u002FS0037-1963(00)90014-3",{"doi":2161},{"id":24,"text":2164,"url":24,"identifiers":2165},"10.1038\u002Fng0496-368",{"doi":2164},{"id":24,"text":2167,"url":24,"identifiers":2168},"10.1038\u002Fsj.ejhg.5200265",{"doi":2167},{"id":24,"text":2170,"url":24,"identifiers":2171},"10.1177\u002F002215540004800509",{"doi":2170},{"id":24,"text":2173,"url":24,"identifiers":2174},"10.1016\u002Fj.bone.2005.05.008",{"doi":2173},{"id":24,"text":2176,"url":24,"identifiers":2177},"10.1002\u002Fcyto.a.20053",{"doi":2176},{"id":24,"text":2179,"url":24,"identifiers":2180},"10.1002\u002Fcyto.a.20140",{"doi":2179},{"id":24,"text":2182,"url":24,"identifiers":2183},"10.1016\u002FS0014-5793(02)03508-1",{"doi":2182},{"id":2185,"createTime":2186,"updateTime":2187,"relativeEntities":2188,"slug":2189,"properties":2190,"entityType":139,"verifyStatus":140,"verifyTime":2186,"verifyNote":141,"syncStatus":23,"languages":2208,"translateLanguages":2209,"viewCount":25,"primaryUrl":2210,"fullTextUrl":24,"authors":2211,"publicationType":184,"publisherRelationship":2365,"citationCount":2398,"citationInfo":2399,"publishDate":2410,"publishYear":2411,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":2412,"isForceReanalyzing":278},"630f8c1c-bcab-4c15-bfc8-320a7d7911d1","2024-09-25T06:12:48.894+00:00","2025-02-03T18:48:36.059+00:00",[],"Normalization-of-mass-cytometry-data-with-bead-standards",{"mag":2191,"keywords":2193,"pmc":2194,"openalex":2196,"abstract":2198,"title":2201,"pm":2204,"doi":2206},{"VOID":2192},"2038426170",{"VI":289},{"VOID":2195},"3688049",{"VOID":2197},"W2038426170",{"VI":2199,"EN":2200},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Xét nghiệm khối lượng sử dụng phổ khối lượng nguyên tử kết hợp với các nguyên tố báo cáo tinh khiết đồng vị để đo hiện nay tới 40 tham số trên mỗi tế bào duy nhất. Giống như bất kỳ công nghệ định lượng nào, có một nhu cầu cơ bản về các quy trình đảm bảo chất lượng và chuẩn hóa. Trong trường hợp xét nghiệm khối lượng, biến động tín hiệu theo thời gian do sự thay đổi trong hiệu suất của thiết bị kết hợp với khoảng thời gian giữa các lần bảo trì định kỳ cần phải được tính đến và sau đó chuẩn hóa. Ở đây, các mẫu đã được trộn với các hạt polystyrene nhúng kim loại lanthanide, cho phép theo dõi hiệu suất của thiết bị xét nghiệm khối lượng trong nhiều ngày thu thập dữ liệu. Quy trình được mô tả ở đây bao gồm việc đo đồng thời các hạt và tế bào trên máy xét nghiệm khối lượng, chiết xuất chữ ký dựa trên hạt, và áp dụng một thuật toán cho phép điều chỉnh cả biến động tín hiệu ngắn hạn và dài hạn. Biến động trong cường độ của các hạt còn lại sau khi chuẩn hóa cũng có thể được sử dụng để xác định chất lượng dữ liệu. Việc áp dụng thuật toán cho một phân tích theo chiều dọc kéo dài một tháng của một mẫu máu ngoại biên người đã giảm biên độ dao động tín hiệu trung vị từ 4,9 lần xuống còn 1,3 lần. © 2013 Hiệp hội Quốc tế về Phát triển Xét nghiệm tế bào\u003C\u002Fjats:p>","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Mass cytometry uses atomic mass spectrometry combined with isotopically pure reporter elements to currently measure as many as 40 parameters per single cell. As with any quantitative technology, there is a fundamental need for quality assurance and normalization protocols. In the case of mass cytometry, the signal variation over time due to changes in instrument performance combined with intervals between scheduled maintenance must be accounted for and then normalized. Here, samples were mixed with polystyrene beads embedded with metal lanthanides, allowing monitoring of mass cytometry instrument performance over multiple days of data acquisition. The protocol described here includes simultaneous measurements of beads and cells on the mass cytometer, subsequent extraction of the bead‐based signature, and the application of an algorithm enabling correction of both short‐ and long‐term signal fluctuations. The variation in the intensity of the beads that remains after normalization may also be used to determine data quality. Application of the algorithm to a one‐month longitudinal analysis of a human peripheral blood sample reduced the range of median signal fluctuation from 4.9‐fold to 1.3‐fold. © 2013 International Society for Advancement of Cytometry\u003C\u002Fjats:p>",{"VI":2202,"EN":2203},"Chuẩn hóa dữ liệu xét nghiệm khối lượng bằng các tiêu chuẩn hạt","Normalization of mass cytometry data with bead standards",{"VOID":2205},"23512433",{"VOID":2207},"10.1002\u002Fcyto.a.22271",[143],[304],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcyto.a.22271",[2212,2230,2247,2269,2284,2298,2317,2334,2351],{"id":2213,"sortIndex":372,"researcher":24,"roles":2214,"affiliations":2215,"properties":2226},"28576947-9fa5-4bf7-8000-45eb9340c7de",[],[2216],{"id":2217,"sortIndex":25,"affiliation":2218,"properties":24},"af03bd77-ddc2-423c-a1c3-ba2886fbb9d1",{"id":2219,"createTime":2220,"updateTime":2220,"relativeEntities":2221,"slug":2222,"properties":2223,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"a8ae32fd-042a-434f-9fc5-30e8a9f53521","2024-09-25T06:12:48.961+00:00",[],"Baxter-Laboratory-in-Stem-Cell-Biology-Department-of-Microbiology-and-Immunology-Stanford-University-Stanford-California",{"title":2224},{"EN":2225},"Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, California",{"openalex":2227,"orcid":2228,"title":2229},{"VOID":956},{"VOID":958},{"EN":960},{"id":2231,"sortIndex":148,"researcher":24,"roles":2232,"affiliations":2233,"properties":2240},"746f60eb-845b-4447-ac90-990f87e4dc10",[],[2234],{"id":2235,"sortIndex":25,"affiliation":2236,"properties":24},"f39006e8-343c-4c52-afab-ef9a6cbfb120",{"id":2219,"createTime":2220,"updateTime":2220,"relativeEntities":2237,"slug":2222,"properties":2238,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2239},{"EN":2225},{"openalex":2241,"orcid":2243,"title":2245},{"VOID":2242},"A5082080696",{"VOID":2244},"https:\u002F\u002Forcid.org\u002F0000-0002-3497-4861",{"EN":2246},"Erin F. Simonds",{"id":2248,"sortIndex":71,"researcher":24,"roles":2249,"affiliations":2250,"properties":2262},"ab68c148-028e-41ee-bacb-a6fd46cb759c",[],[2251],{"id":2252,"sortIndex":25,"affiliation":2253,"properties":24},"d7f054d3-c562-43b8-a013-b25bcb08789a",{"id":2254,"createTime":2255,"updateTime":2256,"relativeEntities":2257,"slug":2258,"properties":2259,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"4cef9fe2-d4d8-4ed2-82a8-61f4b32bbab5","2024-01-08T07:27:25.732+00:00","2024-10-10T20:15:11.017+00:00",[],"Department-of-Biological-Sciences-Columbia-University-New-York",{"title":2260},{"VI":2261},"Department of Biological Sciences, Columbia University, New York",{"openalex":2263,"orcid":2265,"title":2267},{"VOID":2264},"A5074451448",{"VOID":2266},"https:\u002F\u002Forcid.org\u002F0000-0002-9259-8817",{"EN":2268},"Dana Pe’er",{"id":2270,"sortIndex":309,"researcher":24,"roles":2271,"affiliations":2272,"properties":2279},"2ade766e-71f4-41cf-921e-93b8529e2981",[],[2273],{"id":2274,"sortIndex":25,"affiliation":2275,"properties":24},"22d0d5df-03c9-4b4a-9315-f5997987b508",{"id":2219,"createTime":2220,"updateTime":2220,"relativeEntities":2276,"slug":2222,"properties":2277,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2278},{"EN":2225},{"openalex":2280,"title":2282},{"VOID":2281},"A5037162036",{"EN":2283},"Astraea Jager",{"id":2285,"sortIndex":218,"researcher":24,"roles":2286,"affiliations":2287,"properties":2294},"51622137-ca4e-4b85-9757-d05bd99ec7fa",[],[2288],{"id":2289,"sortIndex":25,"affiliation":2290,"properties":24},"22b1c40d-8b9e-4395-a0f5-77cff722c5f9",{"id":2219,"createTime":2220,"updateTime":2220,"relativeEntities":2291,"slug":2222,"properties":2292,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2293},{"EN":2225},{"openalex":2295,"orcid":2296,"title":2297},{"VOID":939},{"VOID":941},{"EN":943},{"id":2299,"sortIndex":25,"researcher":24,"roles":2300,"affiliations":2301,"properties":2312},"ad951345-eb0a-4b23-b6e0-174851d836d4",[],[2302],{"id":2303,"sortIndex":25,"affiliation":2304,"properties":24},"75665c1c-678e-4a18-990e-d72fcd694ef3",{"id":2305,"createTime":2306,"updateTime":2306,"relativeEntities":2307,"slug":2308,"properties":2309,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"1b435b2f-a932-4917-8697-b6b67ce1876d","2024-09-25T06:12:48.935+00:00",[],"Baxter-Laboratory-in-Stem-Cell-Biology-Department-of-Microbiology-and-Immunology-Stanford-University-Stanford-California-USA-",{"title":2310},{"EN":2311},"Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, California, USA.",{"openalex":2313,"title":2315},{"VOID":2314},"A5018617539",{"EN":2316},"Rachel Finck",{"id":2318,"sortIndex":390,"researcher":24,"roles":2319,"affiliations":2320,"properties":2327},"de66dd9f-1fe9-4592-89d7-2fe8afe5986c",[],[2321],{"id":2322,"sortIndex":25,"affiliation":2323,"properties":24},"c06536dd-68ca-4f9e-8343-042725b7aa50",{"id":2219,"createTime":2220,"updateTime":2220,"relativeEntities":2324,"slug":2222,"properties":2325,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2326},{"EN":2225},{"openalex":2328,"orcid":2330,"title":2332},{"VOID":2329},"A5001161419",{"VOID":2331},"https:\u002F\u002Forcid.org\u002F0000-0001-9386-4163",{"EN":2333},"Zohar Sachs",{"id":2335,"sortIndex":408,"researcher":24,"roles":2336,"affiliations":2337,"properties":2344},"16c5f5a6-d845-4520-a333-c2ee556d7489",[],[2338],{"id":2339,"sortIndex":25,"affiliation":2340,"properties":24},"643d1739-eb01-4706-b9c0-f4496744827d",{"id":2254,"createTime":2255,"updateTime":2256,"relativeEntities":2341,"slug":2258,"properties":2342,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2343},{"VI":2261},{"openalex":2345,"orcid":2347,"title":2349},{"VOID":2346},"A5045475274",{"VOID":2348},"https:\u002F\u002Forcid.org\u002F0000-0001-5823-1985",{"EN":2350},"Smita Krishnaswamy",{"id":2352,"sortIndex":428,"researcher":24,"roles":2353,"affiliations":2354,"properties":2361},"30af3660-3bce-481e-803b-5d26867a579c",[],[2355],{"id":2356,"sortIndex":25,"affiliation":2357,"properties":24},"578b4e5c-4e8b-4878-b098-4c4058d8e2a4",{"id":2219,"createTime":2220,"updateTime":2220,"relativeEntities":2358,"slug":2222,"properties":2359,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2360},{"EN":2225},{"openalex":2362,"orcid":2363,"title":2364},{"VOID":922},{"VOID":924},{"EN":926},{"url":24,"publisher":2366,"properties":2391},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2367,"slug":10,"properties":2368,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":2374,"manageAffiliations":2375,"indexDatabases":2376,"url":115,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":2369,"issn":2370,"introduce":2371,"eissn":2372,"title":2373},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[2377,2384],{"id":96,"indexDatabase":2378,"url":111,"indexYears":24,"academicFieldIds":2383,"indexDatabaseRanking":24},{"id":98,"createTime":99,"updateTime":100,"relativeEntities":2379,"label":2380,"description":2381,"key":107,"publicationTags":2382,"standard":24},[],{"EN":103,"VI":103},{"VI":105,"EN":106},[109,110],[113,114],{"id":75,"indexDatabase":2385,"url":88,"indexYears":89,"academicFieldIds":2390,"indexDatabaseRanking":94},{"id":77,"createTime":78,"updateTime":79,"relativeEntities":2386,"label":2387,"description":2388,"key":85,"publicationTags":2389,"standard":24},[],{"EN":82,"VI":82},{"EN":82,"VI":84},[87],[91,92,93],{"volume":2392,"pages":2394,"issue":2396},{"VOID":2393},"83A",{"VOID":2395},"483-494",{"VOID":2397},"5",666,{"total":2398,"publishYear":24,"statisticByYear":2400},{"2013":309,"2014":515,"2015":2401,"2016":2043,"2017":2402,"2018":2403,"2019":2404,"2020":2405,"2021":2406,"2022":2407,"2023":2408,"2024":2409},28,54,63,108,86,87,78,66,52,"2013-05-01",2013,[2413,2415,2417,2420,2423,2426,2429,2432,2435],{"id":24,"text":1026,"url":24,"identifiers":2414},{"doi":1026},{"id":24,"text":1029,"url":24,"identifiers":2416},{"doi":1029},{"id":24,"text":2418,"url":24,"identifiers":2419},"10.1002\u002Fcyto.a.20823",{"doi":2418},{"id":24,"text":2421,"url":24,"identifiers":2422},"10.1038\u002Fnprot.2006.250",{"doi":2421},{"id":24,"text":2424,"url":24,"identifiers":2425},"Dendrou CA, 2009, Fluorescence intensity normalisation: Correcting for time effects in large‐scale flow cytometric analysis, Adv Bioinfo, 476106",{},{"id":24,"text":2427,"url":24,"identifiers":2428},"10.1039\u002Fb921770c",{"doi":2427},{"id":24,"text":2430,"url":24,"identifiers":2431},"10.1021\u002Fja9052009",{"doi":2430},{"id":24,"text":2433,"url":24,"identifiers":2434},"10.1016\u002Fj.jim.2010.07.002",{"doi":2433},{"id":24,"text":2436,"url":24,"identifiers":2437},"10.1038\u002Fnbt.2317",{"doi":2436},{"id":2439,"createTime":2440,"updateTime":2441,"relativeEntities":2442,"slug":2443,"properties":2444,"entityType":139,"verifyStatus":140,"verifyTime":2440,"verifyNote":141,"syncStatus":23,"languages":2459,"translateLanguages":2460,"viewCount":25,"primaryUrl":2461,"fullTextUrl":24,"authors":2462,"publicationType":184,"publisherRelationship":2547,"citationCount":2579,"citationInfo":2580,"publishDate":2592,"publishYear":222,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":2593,"isForceReanalyzing":278},"9b39697b-aa63-4365-a220-34d2224f0564","2024-10-07T04:31:14.644+00:00","2025-02-03T18:47:38.524+00:00",[],"Phenotype-and-function-of-human-T-lymphocyte-subsets-Consensus-and-issues",{"mag":2445,"keywords":2447,"openalex":2448,"abstract":2450,"title":2453,"pm":2456,"doi":2458},{"VOID":2446},"1574493485",{"VI":289},{"VOID":2449},"W1574493485",{"VI":2451,"EN":2452},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Trong những năm gần đây, đã có sự nỗ lực to lớn trong việc khắc họa chi tiết về kiểu hình và chức năng của các phân nhóm tế bào T khác nhau ở người, cũng như các con đường phân hóa và vai trò của chúng trong các phản ứng miễn dịch. Tuy nhiên, các nghiên cứu này dường như đã tạo ra nhiều câu hỏi hơn là những câu trả lời rõ ràng. Để làm rõ các vấn đề liên quan đến chức năng và sự phân hóa của các phân nhóm tế bào T, một phiên hội thảo tại hội nghị MASIR 2008 đã được dành riêng cho chủ đề này. Nhiều điểm đồng thuận và bất đồng đã được làm nổi bật trong công trình được trình bày trong phiên này. Chúng tôi ở đây cung cấp một bản trình bày về những điểm này, bao gồm sự đa dạng tương đối của các phân nhóm tế bào T trong các nhiễm trùng do các tác nhân gây bệnh khác nhau, mối quan hệ giữa các đặc điểm kiểu hình và chức năng của tế bào T, và các con đường phân hóa của tế bào T. Cuối cùng, chúng tôi thảo luận về những vấn đề vẫn còn hạn chế sự đồng thuận chung. Xuất bản năm 2008, Wiley-Liss, Inc.\u003C\u002Fjats:p>","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>In recent years, a tremendous effort has been devoted to the detailed characterization of the phenotype and function of distinct T cell subpopulations in humans, as well as to their pathway(s) of differentiation and role in immune responses. But these studies seem to have generated more questions than definitive answers. To clarify issues related to the function and differentiation of T cell subsets, one session of the MASIR 2008 conference was dedicated to this topic. Several points of consensus and discord were highlighted in the work presented during this session. We provide here an account of these points, including the relative heterogeneity of T cell subpopulations during infections with distinct pathogens, the relationship between phenotypic and functional T cell attributes, and the pathway(s) of T cell differentiation. Finally, we discuss the problems which still limit general agreement. Published 2008 Wiley‐Liss, Inc.\u003C\u002Fjats:p>",{"VI":2454,"EN":2455},"Hiện tượng và chức năng của các phân nhóm lymphocyte T ở người: Sự đồng thuận và vấn đề","Phenotype and function of human T lymphocyte subsets: Consensus and issues",{"VOID":2457},"18785267",{"VOID":1781},[143],[304],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcyto.a.20643",[2463,2484,2505,2526],{"id":2464,"sortIndex":408,"researcher":24,"roles":2465,"affiliations":2466,"properties":2477},"af17a291-f2fb-483c-af48-4129376971f9",[],[2467],{"id":2468,"sortIndex":25,"affiliation":2469,"properties":24},"14c006cb-ddc2-4e65-8069-88270aaea347",{"id":2470,"createTime":2471,"updateTime":2471,"relativeEntities":2472,"slug":2473,"properties":2474,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"0f900bbb-965f-4fee-9aa1-0506341001ac","2024-10-07T04:31:14.699+00:00",[],"Vaccine-Research-Center-National-Institutes-of-Health-Bethesda-Maryland-20892",{"title":2475},{"EN":2476},"Vaccine Research Center, National Institutes of Health, Bethesda, Maryland 20892",{"openalex":2478,"orcid":2480,"title":2482},{"VOID":2479},"A5090939942",{"VOID":2481},"https:\u002F\u002Forcid.org\u002F0000-0001-7448-7040",{"EN":2483},"Mario Roederer",{"id":2485,"sortIndex":148,"researcher":24,"roles":2486,"affiliations":2487,"properties":2498},"bdb29ad7-e6e6-426b-93e3-62a991bfa617",[],[2488],{"id":2489,"sortIndex":25,"affiliation":2490,"properties":24},"5c397ea4-a488-463e-974a-a0e4d04f4f3b",{"id":2491,"createTime":2492,"updateTime":2492,"relativeEntities":2493,"slug":2494,"properties":2495,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"c6b35065-c5f8-4d32-9c91-96dd5c3d1c18","2024-10-07T04:31:14.675+00:00",[],"Department-of-Experimental-Immunology-Academic-Medical-Center-Amsterdam-Meibergdreef-15-1105-AZ-Amsterdam-The-Netherlands",{"title":2496},{"EN":2497},"Department of Experimental Immunology, Academic Medical Center, Amsterdam, Meibergdreef, 15, 1105 AZ, Amsterdam, The Netherlands",{"openalex":2499,"orcid":2501,"title":2503},{"VOID":2500},"A5032410098",{"VOID":2502},"https:\u002F\u002Forcid.org\u002F0000-0002-3201-7144",{"EN":2504},"René A. W. van Lier",{"id":2506,"sortIndex":25,"researcher":24,"roles":2507,"affiliations":2508,"properties":2519},"9673381a-3401-42d6-a36d-9410f1236352",[],[2509],{"id":2510,"sortIndex":25,"affiliation":2511,"properties":24},"a0be92aa-dead-4e6f-8cd9-392abc63fe24",{"id":2512,"createTime":2513,"updateTime":2513,"relativeEntities":2514,"slug":2515,"properties":2516,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"5b1ced8e-1be1-4273-880b-0ac8e08976b0","2024-10-07T04:31:14.663+00:00",[],"Cellular-Immunology-Laboratory-INSERM-U543-Avenir-Group-H%C3%B4pital-Piti%C3%A9-Salp%C3%AAtri%C3%A8re-Universit%C3%A9-Pierre-et-Marie-Curie-Paris6-75013-Paris-France",{"title":2517},{"EN":2518},"Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hôpital Pitié-Salpêtrière, Université Pierre et Marie Curie-Paris6, 75013 Paris, France",{"openalex":2520,"orcid":2522,"title":2524},{"VOID":2521},"A5044666153",{"VOID":2523},"https:\u002F\u002Forcid.org\u002F0000-0001-5434-3963",{"EN":2525},"Victor Appay",{"id":2527,"sortIndex":309,"researcher":24,"roles":2528,"affiliations":2529,"properties":2540},"1c8b1113-acef-43ec-88c8-ea36c9e433ba",[],[2530],{"id":2531,"sortIndex":25,"affiliation":2532,"properties":24},"97e2df5e-d20f-48b2-be00-170abbe34ad1",{"id":2533,"createTime":2534,"updateTime":2534,"relativeEntities":2535,"slug":2536,"properties":2537,"entityType":61,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"e6191d94-52ad-4308-99be-850a3c596547","2024-10-07T04:31:14.687+00:00",[],"Institute-for-Research-in-Biomedicine-Via-Vincenzo-Vela-6-CH-6500-Bellinzona-Switzerland",{"title":2538},{"EN":2539},"Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH‐6500 Bellinzona, Switzerland",{"openalex":2541,"orcid":2543,"title":2545},{"VOID":2542},"A5047171254",{"VOID":2544},"https:\u002F\u002Forcid.org\u002F0000-0003-3750-2752",{"EN":2546},"Federica Sallusto",{"url":24,"publisher":2548,"properties":2573},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2549,"slug":10,"properties":2550,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":2556,"manageAffiliations":2557,"indexDatabases":2558,"url":115,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":2551,"issn":2552,"introduce":2553,"eissn":2554,"title":2555},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[2559,2566],{"id":96,"indexDatabase":2560,"url":111,"indexYears":24,"academicFieldIds":2565,"indexDatabaseRanking":24},{"id":98,"createTime":99,"updateTime":100,"relativeEntities":2561,"label":2562,"description":2563,"key":107,"publicationTags":2564,"standard":24},[],{"EN":103,"VI":103},{"VI":105,"EN":106},[109,110],[113,114],{"id":75,"indexDatabase":2567,"url":88,"indexYears":89,"academicFieldIds":2572,"indexDatabaseRanking":94},{"id":77,"createTime":78,"updateTime":79,"relativeEntities":2568,"label":2569,"description":2570,"key":85,"publicationTags":2571,"standard":24},[],{"EN":82,"VI":82},{"EN":82,"VI":84},[87],[91,92,93],{"volume":2574,"pages":2575,"issue":2577},{"VOID":213},{"VOID":2576},"975-983",{"VOID":2578},"11",697,{"total":2579,"publishYear":24,"statisticByYear":2581},{"2012":2582,"2013":2583,"2014":2584,"2015":2585,"2016":2586,"2017":2587,"2018":2588,"2019":2589,"2020":2590,"2021":2591,"2022":1012,"2023":768,"2024":519},55,73,53,59,51,48,40,45,44,39,"2008-11-01",[2594,2597,2600,2603,2606,2608,2611,2614,2617,2620,2623,2626,2629,2632,2635,2638,2641,2644,2647,2650,2653,2656,2659,2662,2665,2668,2671,2674,2677,2680,2683,2686,2689,2692,2695,2698,2701,2704,2707,2710,2713,2716,2719,2722,2725,2728,2731,2734,2737,2740,2743,2746,2749,2752,2755,2758,2761,2764,2767,2769,2772,2775,2778,2781,2784,2787,2790,2793,2796,2799,2802,2805,2808,2811,2814],{"id":24,"text":2595,"url":24,"identifiers":2596},"10.1084\u002Fjem.183.4.1367",{"doi":2595},{"id":24,"text":2598,"url":24,"identifiers":2599},"10.1126\u002Fscience.166.3906.747",{"doi":2598},{"id":24,"text":2601,"url":24,"identifiers":2602},"10.1084\u002Fjem.186.9.1407",{"doi":2601},{"id":24,"text":2604,"url":24,"identifiers":2605},"10.1038\u002F44385",{"doi":2604},{"id":24,"text":1565,"url":24,"identifiers":2607},{"doi":1565},{"id":24,"text":2609,"url":24,"identifiers":2610},"10.1038\u002F84701",{"doi":2609},{"id":24,"text":2612,"url":24,"identifiers":2613},"10.4049\u002Fjimmunol.165.4.1910",{"doi":2612},{"id":24,"text":2615,"url":24,"identifiers":2616},"10.4049\u002Fjimmunol.164.3.1148",{"doi":2615},{"id":24,"text":2618,"url":24,"identifiers":2619},"10.4049\u002Fjimmunol.167.1.212",{"doi":2618},{"id":24,"text":2621,"url":24,"identifiers":2622},"10.4049\u002Fjimmunol.167.11.6165",{"doi":2621},{"id":24,"text":2624,"url":24,"identifiers":2625},"10.1016\u002FS0952-7915(00)00242-9",{"doi":2624},{"id":24,"text":2627,"url":24,"identifiers":2628},"10.1093\u002Fintimm\u002F13.4.593",{"doi":2627},{"id":24,"text":2630,"url":24,"identifiers":2631},"10.4049\u002Fjimmunol.168.11.5455",{"doi":2630},{"id":24,"text":2633,"url":24,"identifiers":2634},"10.4049\u002Fjimmunol.168.11.5538",{"doi":2633},{"id":24,"text":2636,"url":24,"identifiers":2637},"10.4049\u002Fjimmunol.168.5.2225",{"doi":2636},{"id":24,"text":2639,"url":24,"identifiers":2640},"10.1182\u002Fblood-2002-02-0657",{"doi":2639},{"id":24,"text":2642,"url":24,"identifiers":2643},"10.1097\u002F00002030-200306130-00002",{"doi":2642},{"id":24,"text":2645,"url":24,"identifiers":2646},"10.1182\u002Fblood-2002-07-2103",{"doi":2645},{"id":24,"text":2648,"url":24,"identifiers":2649},"10.1182\u002Fblood-2003-02-0420",{"doi":2648},{"id":24,"text":2651,"url":24,"identifiers":2652},"10.1097\u002F01.aids.0000191919.24185.46",{"doi":2651},{"id":24,"text":2654,"url":24,"identifiers":2655},"10.1182\u002Fblood-2005-02-0449",{"doi":2654},{"id":24,"text":2657,"url":24,"identifiers":2658},"10.1128\u002FJVI.79.18.12112-12116.2005",{"doi":2657},{"id":24,"text":2660,"url":24,"identifiers":2661},"10.1189\u002Fjlb.1205725",{"doi":2660},{"id":24,"text":2663,"url":24,"identifiers":2664},"10.1097\u002FQAD.0b013e3282eee548",{"doi":2663},{"id":24,"text":2666,"url":24,"identifiers":2667},"10.1002\u002Feji.200526122",{"doi":2666},{"id":24,"text":2669,"url":24,"identifiers":2670},"10.4049\u002Fjimmunol.177.7.4330",{"doi":2669},{"id":24,"text":2672,"url":24,"identifiers":2673},"10.1084\u002Fjem.187.6.875",{"doi":2672},{"id":24,"text":2675,"url":24,"identifiers":2676},"10.1084\u002Fjem.20040774",{"doi":2675},{"id":24,"text":2678,"url":24,"identifiers":2679},"10.1038\u002Fni1467",{"doi":2678},{"id":24,"text":2681,"url":24,"identifiers":2682},"10.1084\u002Fjem.20070663",{"doi":2681},{"id":24,"text":2684,"url":24,"identifiers":2685},"10.1002\u002Feji.200737768",{"doi":2684},{"id":24,"text":2687,"url":24,"identifiers":2688},"10.1371\u002Fjournal.pbio.0020020",{"doi":2687},{"id":24,"text":2690,"url":24,"identifiers":2691},"10.4049\u002Fjimmunol.178.7.4112",{"doi":2690},{"id":24,"text":2693,"url":24,"identifiers":2694},"10.1086\u002F368218",{"doi":2693},{"id":24,"text":2696,"url":24,"identifiers":2697},"10.1086\u002F367707",{"doi":2696},{"id":24,"text":2699,"url":24,"identifiers":2700},"10.1084\u002Fjem.20022058",{"doi":2699},{"id":24,"text":2702,"url":24,"identifiers":2703},"10.4049\u002Fjimmunol.172.4.2476",{"doi":2702},{"id":24,"text":2705,"url":24,"identifiers":2706},"10.1182\u002Fblood-2003-04-1203",{"doi":2705},{"id":24,"text":2708,"url":24,"identifiers":2709},"10.1172\u002FJCI200318509",{"doi":2708},{"id":24,"text":2711,"url":24,"identifiers":2712},"10.1128\u002FJVI.78.13.7284-7287.2004",{"doi":2711},{"id":24,"text":2714,"url":24,"identifiers":2715},"10.1182\u002Fblood-2003-01-0183",{"doi":2714},{"id":24,"text":2717,"url":24,"identifiers":2718},"10.4049\u002Fjimmunol.172.10.6107",{"doi":2717},{"id":24,"text":2720,"url":24,"identifiers":2721},"10.1034\u002Fj.1600-0528.2002.017416.x",{"doi":2720},{"id":24,"text":2723,"url":24,"identifiers":2724},"10.4049\u002Fjimmunol.173.3.1834",{"doi":2723},{"id":24,"text":2726,"url":24,"identifiers":2727},"10.1038\u002Fnri2274",{"doi":2726},{"id":24,"text":2729,"url":24,"identifiers":2730},"10.1073\u002Fpnas.0502393102",{"doi":2729},{"id":24,"text":2732,"url":24,"identifiers":2733},"10.1182\u002Fblood-2005-12-4818",{"doi":2732},{"id":24,"text":2735,"url":24,"identifiers":2736},"10.1084\u002Fjem.20062363",{"doi":2735},{"id":24,"text":2738,"url":24,"identifiers":2739},"10.1182\u002Fblood-2002-08-2502",{"doi":2738},{"id":24,"text":2741,"url":24,"identifiers":2742},"10.1016\u002FS0092-8674(02)01139-X",{"doi":2741},{"id":24,"text":2744,"url":24,"identifiers":2745},"10.1084\u002Fjem.20061496",{"doi":2744},{"id":24,"text":2747,"url":24,"identifiers":2748},"10.1002\u002F(SICI)1521-4141(199906)29:06\u003C2037::AID-IMMU2037>3.0.CO;2-V",{"doi":2747},{"id":24,"text":2750,"url":24,"identifiers":2751},"10.1093\u002Fintimm\u002Fdxh251",{"doi":2750},{"id":24,"text":2753,"url":24,"identifiers":2754},"10.1038\u002Fni1469",{"doi":2753},{"id":24,"text":2756,"url":24,"identifiers":2757},"10.4049\u002Fjimmunol.168.1.29",{"doi":2756},{"id":24,"text":2759,"url":24,"identifiers":2760},"10.1016\u002Fj.immuni.2007.10.012",{"doi":2759},{"id":24,"text":2762,"url":24,"identifiers":2763},"10.1016\u002FS1074-7613(01)00236-9",{"doi":2762},{"id":24,"text":2765,"url":24,"identifiers":2766},"10.4049\u002Fjimmunol.170.1.33",{"doi":2765},{"id":24,"text":1577,"url":24,"identifiers":2768},{"doi":1577},{"id":24,"text":2770,"url":24,"identifiers":2771},"10.4049\u002Fjimmunol.179.11.7406",{"doi":2770},{"id":24,"text":2773,"url":24,"identifiers":2774},"10.1084\u002Fjem.192.1.63",{"doi":2773},{"id":24,"text":2776,"url":24,"identifiers":2777},"10.1038\u002F35065118",{"doi":2776},{"id":24,"text":2779,"url":24,"identifiers":2780},"10.1084\u002Fjem.20070784",{"doi":2779},{"id":24,"text":2782,"url":24,"identifiers":2783},"10.1084\u002Fjem.20042408",{"doi":2782},{"id":24,"text":2785,"url":24,"identifiers":2786},"10.1038\u002Fni889",{"doi":2785},{"id":24,"text":2788,"url":24,"identifiers":2789},"10.1172\u002FJCI24480",{"doi":2788},{"id":24,"text":2791,"url":24,"identifiers":2792},"10.1128\u002FJVI.01458-06",{"doi":2791},{"id":24,"text":2794,"url":24,"identifiers":2795},"10.1172\u002FJCI32103",{"doi":2794},{"id":24,"text":2797,"url":24,"identifiers":2798},"10.1038\u002Fnm1592",{"doi":2797},{"id":24,"text":2800,"url":24,"identifiers":2801},"Hesperger AR, 2008, Flow cytometric detection of perforin upregulation in human CD8 T cells, Cytometry Part A, 73A",{},{"id":24,"text":2803,"url":24,"identifiers":2804},"van Baalen C, 2008, FATT‐CTL assay for detection of antigen‐specific cell‐mediated cytotoxicity, Cytometry Part A, 73A",{},{"id":24,"text":2806,"url":24,"identifiers":2807},"Chattopadhyay P, 2008, Techniques to improve the direct ex vivo detection of low frequency antigen‐specific CD8+ T cells with peptide‐major histocompatibility complex class I tetramers, Cytometry Part A, 73A",{},{"id":24,"text":2809,"url":24,"identifiers":2810},"Fuhrmann S, 2008, How flow cytometry is changing the study of TB immunology and clinical diagnosis, Cytometry Part A, 73A",{},{"id":24,"text":2812,"url":24,"identifiers":2813},"Cecconi V, 2008, Use of MHC Class II tetramers to investigate CD4+ T cell responses: Problems and solutions, Cytometry Part A, 73A",{},{"id":24,"text":2815,"url":24,"identifiers":2816},"Meier S, 2008, The influence of different stimulation conditions on the assessment of antigen‐induced CD154 expression on CD4+ T cells, Cytometry Part A, 73A",{}]