[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_5a2132a7-9da9-4dc3-8d1b-d03b489dffd4":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:5a2132a7-9da9-4dc3-8d1b-d03b489dffd4,\"}":87},{"code":4,"data":5,"meta":18},"SUCCESS",{"id":6,"createTime":7,"updateTime":8,"relativeEntities":9,"slug":10,"properties":11,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":20,"manageAffiliations":27,"indexDatabases":36,"url":54,"thumbnailPath":18,"statistic":55,"gsStatistic":18,"type":86,"analyzePriority":18},"5a2132a7-9da9-4dc3-8d1b-d03b489dffd4","2024-04-11T04:24:09.070+00:00","2025-11-21T10:01:13.860+00:00",[],"Current-Treatment-Options-in-Pediatrics",{"issn":12,"title":14},{"VOID":13},"2198-6088",{"EN":15},"Current Treatment Options in Pediatrics","PUBLISHER","PENDING",null,0,[21],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":23,"label":24,"description":26,"parentId":18,"standard":18,"scholarHubFieldId":18},"5870d53f-1c88-45cf-b26b-c48667a544de",[],{"EN":25},"Pediatrics, Perinatology and Child Health",{},[28],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":30,"slug":18,"properties":31,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":34,"statistic":18},"ca0dc894-2cfd-4536-8558-d78518e3e721",[],{"title":32},{"EN":33},"Springer International Publishing AG",[35],"9a7c7208-b28a-42c2-a634-5a7f90eee3ab",[37],{"id":38,"indexDatabase":39,"url":49,"indexYears":50,"academicFieldIds":51,"indexDatabaseRanking":53},"137c58df-6255-4521-b97e-1e70015a8ffa",{"id":40,"createTime":18,"updateTime":18,"relativeEntities":41,"label":42,"description":44,"key":46,"publicationTags":47,"standard":18},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9",[],{"EN":43,"VI":43},"Scopus - Elsevier",{"EN":43,"VI":45},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[48],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F21100854820","2015-2017,2019-2025",[52],"2a49c7d8-bbba-4081-b827-942cc7f24661","SCOPUS__Q4","https:\u002F\u002Flink.springer.com\u002Fjournal\u002F40746",{"impactFactor":19,"impactFactorByYear":56,"i10Index":62,"i10IndexLast5Year":62,"totalPublication":63,"totalPublicationByYear":64,"totalCitation":74,"totalCitationByYear":75,"totalCitationPerPublication":80,"totalCitationPerPublicationByYear":81,"hindexLast5Year":76,"hindex":76},{"2017":57,"2020":58,"2021":59,"2022":60,"2023":61},0.04,0.06,0.12,0.02,0.03,2,229,{"2014":65,"2015":66,"2016":67,"2017":68,"2018":69,"2019":70,"2020":71,"2021":72,"2022":73,"2023":72},1,23,26,24,28,37,27,17,22,67,{"2015":76,"2016":77,"2018":65,"2019":78,"2020":79,"2021":76},5,4,48,3,0.29,{"2015":82,"2016":83,"2018":57,"2019":84,"2020":85,"2021":80},0.22,0.15,1.3,0.11,"JOURNAL",{"meta":88,"data":90},{"total":89},"195",[91,182,273,480,620,705,788,882,950,1106],{"id":92,"createTime":93,"updateTime":94,"relativeEntities":95,"slug":96,"properties":97,"entityType":108,"verifyStatus":109,"verifyTime":110,"verifyNote":111,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":112,"fullTextUrl":18,"authors":113,"publicationType":139,"publisherRelationship":140,"citationCount":19,"citationInfo":175,"publishDate":178,"publishYear":176,"citationAnalyzeStatus":17,"lastCitationAnalyze":179,"indexDatabases":180,"openAccess":18,"references":18,"isForceReanalyzing":181},"c0bbc897-8ea7-419f-809b-aaa83227097a","2024-01-28T13:03:25.496+00:00","2026-07-23T07:34:24.572+00:00",[],"Building-a-Culture-of-Safety-in-Pediatrics-and-Child-Health",{"abstract":98,"title":100,"gsPaper":102,"references":104,"doi":106},{"EN":99},"While there have been significant technical advances in the provision of health care to children, there remains ongoing challenges in developing a culture of safety in pediatrics and child health. In many health systems, quality and safety programs are fragmented and the results variable. Health leaders need to ensure that care remains compassionate, child centered, and reliable across the systems in which they work. In order to transform our health system, we need to build and spread a culture of safety and reliability. Understanding the challenges and opportunities required to develop a culture of safety in pediatrics is best explored at three different levels. This paper aims to explore opportunities to build a culture of safety in pediatrics and child health at three levels. The first is the ward or unit base, the second is the hospital or heath system at large, and the third is whole system transformation at state, national, and global level.",{"EN":101},"Building a Culture of Safety in Pediatrics and Child Health",{"VOID":103},"[\"7827394086724117981\"]",{"VOID":105},"Lachman P, Runnacles J, Dudley J. Equipped: overcoming barriers to change to improve quality of care. Arch Dis Child Educ Pract Ed. 2015;100(1):13–8. This paper highlights the obligation that health professionals need to provide reliable and safe care to all children all of the time. The key is developing systems to do this.\nLachman P. Redefining the clinical gaze. BMJ Qual Saf. Online first 2 August 2014. Healthcare can be made safer by making child centered care and the safety of patients the key to developing a high reliable systems approach.\nStockwell D, Bisarya H, Claasen D, et al. A trigger tool to detect harm in pediatric inpatient settings. Pediatrics. 2015;135(6):1593–4. Harm occurs at high rates in children and the trigger tool methodology provides the best way to understand how much harm is happening to children in hospital.\nCarson Stevens A, Edwards A, Panesar S, et al. Reducing the burden of iatrogenic harm in children. Lancet. 2015;385(9978):1593–4.\nRees P, Edwards A, Panesar S, et al. Safety incidents in the primary care setting. Pediatrics. 2015;135(6):1027–35.\nCollins A. http:\u002F\u002Fwww.health.org.uk\u002Fpublications\u002Fmeasuring-what-really-matters\u002F. Accessed April 2014.\nCilfra C, Jones K, Ascenzi J, et al. The morbidity and mortality conference as an adverse event surveillance tool in a pediatric intensive care unit. BMJ Qual Saf. 2014;23:930–8.\nScheifer J, Leonard D. Patient safety and quality improvement: an overview of QI. Paediatr Rev. 2012;33(8):353–9.\nRunnucles J, Moult B, Lachman P. Developing future clinical leaders for quality improvement: an experience from a London children’s hospital. BMJ Qual Saf. 2013;22(11):956–63. Strong clinical leadership is e key to developing safe, effective microsystems for clinicians to work in.\nWoodhead P, Lachman P, Mountford J, et al. From harm to hope and purposeful action: what could we do after Francis? BMJ Qual Saf. 2014;23:619–23. Up skilling and capacity building of front line clinical staff can lead to a sustainable benefit for patients and staff.\nLannon C, Levy F, Moyer C. The need to build capability and capacity in quality improvement and patient safety. Pediatrics. 2015;135(6):e1371–3.\nSexton J, Sharek P, Thomas E, et al. Exposure to leadership walk rounds in neonatal intensive care units is associated with a better patient safety culture and less caregiver burnout. BMJ Qual Saf. 2014;23:814–22.\nAbrahamson E, Hyman D, Osorio S, Kaushal R. Implementing a patient safety and quality program across two merged pediatric institutions. Jt Comm J Qual Patient Saf. 2009;35(1):43–8.\nMiller M, Robinson K, Lubomski L, et al. Medication errors in pediatric care: a systemic review of epidemiology and an evaluation of evidence supporting reduction strategy recommendations. Qual Saf Health Care. 2007;16(2):116–26.\nLepee C, Klaber R, Benn J, et al. The use of a consultant led ward round checklist to improve pediatric prescribing: an interrupted time series study. Eur J Paediatr. 2012;171(8):1239–45.\nGoldenhar L, Brady P, Sutcliffe K, Mouthing S. Huddling for high reliability care. BMJ Qual Saf. 2013;22:899–906.\nMohr J, Betalden P, Barach P. Integrating patient safety into the clinical microsystem. Qual Saf Health Care. 2004;13 suppl 2:ii34–8.\nPronovost P, Armstrong C, Demski R, et al. Creating a high-reliability health care system: improving performance on core processes of care at John Hopkins Medicine. Acad Med. 2015;90(2):165–72.\nBuck D, Kurth C, Varughese A. Perspectives on quality and safety in pediatric anesthesia. Anesthesiol Clin. 2014;32(1):281–94.\nParry G, Horowitz D, Goldmann D. Patient safety attitudes of pediatric trainee physicians. Qual Saf Health Care. 2009;18:462–6.\nBigham M, Logsdon T, Manicone P. Decreasing handoff- related care failures in children’s hospitals. Pediatrics. 2014;134(2):e572–9.\nHughes C, Pain C, Braithwaite J, Hillman K. Between the flags: implementing a rapid response system at scale. BMJ Qual Saf. 2014;23:714–7.\nBrady P, Zix J, Brilli R. Developing and evaluating the sources of a family activated medical emergency team: a quality improvement report. BMJ Qual Saf. 2015;24(3):203–11.\nCox E, Crayon P, Hansen K, et al. Parent perceptions of children’s hospital safety climate. BMJ Qual Saf. 2013;22:664–71.\nLachman P, Linkson L, Evans T, et al. Developing person- centered analysis of harm in a pediatric hospital: a quality improvement report. BMJ Qual Saf. Online first 30 March 2015.\nBell S, Mann K, Truog R, Lantos J. Should we tell parents that we’ve made an error? Pediatrics. 2015;135(1):159–63.\nNewland J, Banerjee R, Gerber J, et al. Antimicrobial stewardship in pediatric care: strategies and future directions. Pharmacotherapy. 2012;32:735–43.\nDellit T, Owens R, McGowan J, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis. 2007;44(2):159–77.\nBest A, Greenhalgh T, Lewis S, et al. Large-scale transformation in health care: a realist review. Millbank Q. 2012;90(3):421–56.\nSAFE program –situational awareness for everyone. www.rcpch.ac.uk\u002Fimproving-child-health\u002Fquality. Accessed May 2015.\nLennon C, Peterson L. Pediatric collaborative networks for quality improvement and research. Acad Pediatr. 2013;13(6):S69–74.\nTaitz J, Genn K, Brooks V, et al. Qual Saf Health Care. Online first 29 July 2010.\nStockwell D, Bisarya H, Classen D, et al. Development of an electronic pediatric all-cause harm measurement tool using a modified Delphi method. J Patient S. Online first 26 August 2014.\nMatlow A, Cronin C, Flintoft V, et al. Description of the development and validation the Canadian pediatric trigger tool. BMJ Qual Saf. 2011;20:416–23.\nChapman S, Fitzsimmons J, Davey N, Lachman P. Prevalence and severity of pediatric harm in a sample of UK-hospitalized children detected by the pediatric trigger tool. BMJ Open. 2014;4:e005066.",{"VOID":107},"10.1007\u002Fs40746-015-0032-6","PUBLICATION","VERIFIED","2024-05-08T12:45:38.238+00:00","Auto Verify","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs40746-015-0032-6",[114],{"id":115,"sortIndex":19,"researcher":18,"roles":116,"affiliations":118,"properties":136,"displayName":138,"givenName":18,"familyName":18},"f7725ed3-a786-4c9f-ad73-6aa9c13b3ec1",[117],"AUTHOR",[119,127],{"id":120,"sortIndex":19,"affiliation":121,"properties":18},"8ff13764-ddcc-4d44-8356-fe66dcc99487",{"id":120,"createTime":18,"updateTime":18,"relativeEntities":122,"slug":18,"properties":123,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":126,"statistic":18},[],{"title":124},{"VI":125},"Clinical Excellence Commission, Sydney, Australia",[],{"id":128,"sortIndex":65,"affiliation":129,"properties":135},"8c814888-8172-467e-a851-10cda512cc77",{"id":128,"createTime":18,"updateTime":18,"relativeEntities":130,"slug":18,"properties":131,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":134,"statistic":18},[],{"title":132},{"VI":133},"Department of Pediatrics, University of New South Wales, Sydney, Australia",[],{},{"title":137},{"VI":138},"Jonny Taitz","ARTICLE",{"url":112,"publisher":141,"properties":170},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":142,"slug":10,"properties":143,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":146,"manageAffiliations":151,"indexDatabases":157,"url":54,"thumbnailPath":18,"statistic":165,"gsStatistic":18,"type":86,"analyzePriority":18},[],{"issn":144,"title":145},{"VOID":13},{"EN":15},[147],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":148,"label":149,"description":150,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[152],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":153,"slug":18,"properties":154,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":156,"statistic":18},[],{"title":155},{"EN":33},[35],[158],{"id":38,"indexDatabase":159,"url":49,"indexYears":50,"academicFieldIds":164,"indexDatabaseRanking":53},{"id":40,"createTime":18,"updateTime":18,"relativeEntities":160,"label":161,"description":162,"key":46,"publicationTags":163,"standard":18},[],{"EN":43,"VI":43},{"EN":43,"VI":45},[48],[52],{"impactFactor":19,"impactFactorByYear":166,"i10Index":62,"i10IndexLast5Year":62,"totalPublication":63,"totalPublicationByYear":167,"totalCitation":74,"totalCitationByYear":168,"totalCitationPerPublication":80,"totalCitationPerPublicationByYear":169,"hindexLast5Year":76,"hindex":76},{"2017":57,"2020":58,"2021":59,"2022":60,"2023":61},{"2014":65,"2015":66,"2016":67,"2017":68,"2018":69,"2019":70,"2020":71,"2021":72,"2022":73,"2023":72},{"2015":76,"2016":77,"2018":65,"2019":78,"2020":79,"2021":76},{"2015":82,"2016":83,"2018":57,"2019":84,"2020":85,"2021":80},{"pages":171,"volume":173},{"VOID":172},"253-261",{"VOID":174},"1",{"total":19,"publishYear":176,"statisticByYear":177},2015,{},"2015-10-12","2026-07-23T07:34:24.571+00:00",[53],false,{"id":183,"createTime":184,"updateTime":185,"relativeEntities":186,"slug":187,"properties":188,"entityType":108,"verifyStatus":109,"verifyTime":199,"verifyNote":111,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":200,"fullTextUrl":18,"authors":201,"publicationType":139,"publisherRelationship":232,"citationCount":19,"citationInfo":267,"publishDate":270,"publishYear":268,"citationAnalyzeStatus":17,"lastCitationAnalyze":271,"indexDatabases":272,"openAccess":18,"references":18,"isForceReanalyzing":181},"f06c0734-eb48-461a-80a2-df2317e67418","2023-12-28T02:42:51.265+00:00","2026-06-21T20:30:45.766+00:00",[],"Chronic-Rhinosinusitis-in-Children",{"abstract":189,"title":191,"gsPaper":193,"references":195,"doi":197},{"EN":190},"Pediatric chronic rhinosinusitis (CRS) is a common condition that is often misdiagnosed and can be challenging to treat. This review aims to (1) review definitions, presentation, complications, and management of CRS in children, and (2) highlight the paucity of evidence in the management of pediatric CRS. There are few studies supporting the usual recommended medical therapy for pediatric CRS (antibiotics, nasal saline irrigations, intranasal steroid). Adenoidectomy remains a mainstay of surgical treatment, but recent evidence demonstrates the utility of balloon sinuplasty and functional endoscopic sinus surgery (FESS) for patients who fail adenoidectomy alone. Pediatric CRS is distinct from ARS and adult CRS. It is a common problem that is poorly studied, in part because of significant symptomatic overlap with related conditions. Recent evidence supports the use of surgical treatment in children who fail medical management. However, further outcome studies are needed to better evaluate the effectiveness of current medical and surgical management protocols.",{"EN":192},"Chronic Rhinosinusitis in Children",{"VOID":194},"[\"7232041194533917384\"]",{"VOID":196},"Novembre E, Mori F, Pucci N, Bernardini R, Vierucci A, de Martino M. Systemic treatment of rhinosinusitis in children. Pediatr Allergy Immunol. 2007;18(Suppl 18):56–61.\nZacharisen M, Casper R. Pediatric sinusitis. Immunol Allergy Clin N Am. 2005;25(2):313–32 vii.\nMagit A. Pediatric rhinosinusitis. Otolaryngol Clin N Am. 2014;47(5):733–46.\nBrietzke SE, Shin JJ, Choi S, Lee JT, Parikh SR, Pena M, et al. Clinical consensus statement: pediatric chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2014;151(4):542–53.\nCunningham MJ, Chiu EJ, Landgraf JM, Gliklich RE. The health impact of chronic recurrent rhinosinusitis in children. Arch Otolaryngol Head Neck Surg. 2000;126(11):1363–8.\nBeswick DM, Messner AH, Hwang PH. Pediatric chronic rhinosinusitis management in rhinologists and pediatric otolaryngologists. Ann Otol Rhinol Laryngol. 2017;126(9):634–9.\n• Gilani S, Shin JJ. The burden and visit prevalence of pediatric chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2017;157(6):1048–52 This study demonstrates the national burden of CRS using a national database of ambulatory visits and places this in context with other common otolaryngological disorders.\nVan Buchem FL, Peeters MF, Knottnerus JA. Maxillary sinusitis in children. Clin Otolaryngol Allied Sci. 1992;17(1):49–53.\nNguyen KL, Corbett ML, Garcia DP, et al. Chronic sinusitis among pediatric patients with chronic respiratory complaints. J Allergy Clin Immunol. 1993;92(6):824–30.\nFokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology. 2012;50(1):1–12.\nRose AS, Thorp BD, Zanation AM, Ebert CS Jr. Chronic rhinosinusitis in children. Pediatr Clin N Am. 2013;60(4):979–91.\nChristensen DN, Franks ZG, McCrary HC, Saleh AA, Chang EH. A systematic review of the association between cigarette smoke exposure and chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2018;158(5):801–16.\nRachelefsky GS, Goldberg M, Katz RM, et al. Sinus disease in children with respiratory allergy. J Allergy Clin Immunol. 1978;61(5):310–4.\nPrincipi N, Esposito S. New insights into pediatric rhinosinusitis. Pediatr Allergy Immunol. 2007;18(Suppl 18):7–9.\nMener DJ, Lin SY, Ishman SL, Boss EF. Treatment and outcomes of chronic rhinosinusitis in children with primary ciliary dyskinesia: where is the evidence? A qualitative systematic review. Int Forum Allergy Rhinol. 2013;3(12):986–91.\nFitzgerald DA, Shapiro AJ. When to suspect primary ciliary dyskinesia in children. Paediatr Respir Rev. 2016;18:3–7.\nAbreu NA, Nagalingam NA, Song Y, Roediger FC, Pletcher SD, Goldberg AN, et al. Sinus microbiome diversity depletion and Corynebacterium tuberculostearicum enrichment mediates rhinosinusitis. Sci Transl Med. 2012;4(151):151ra124.\nMuntz HR, Lusk RP. Bacteriology of the ethmoid bullae in children with chronic sinusitis. Arch Otolaryngol Head Neck Surg. 1991;117(2):179–81.\nDiament MJ, Senac MO Jr, Gilsanz V, Baker S, Gillespie T, Larsson S. Prevalence of incidental paranasal sinuses opacification in pediatric patients: a CT study. J Comput Assist Tomogr. 1987;11(3):426–31.\nHill M, Bhattacharyya N, Hall TR, Lufkin R, Shapiro NL. Incidental paranasal sinus imaging abnormalities and the normal Lund score in children. Otolaryngol Head Neck Surg. 2004;130(2):171–5.\nKennedy DW, Josephson JS, Zinreich SJ, Mattox DE, Goldsmith MM. Endoscopic sinus surgery for mucoceles: a viable alternative. Laryngoscope. 1989;99(9):885–95.\nBenninger MS, Marks S. The endoscopic management of sphenoid and ethmoid mucoceles with orbital and intranasal extension. Rhinology. 1995;33(3):157–61.\nCampbell JM, Graham M, Gray HC, Bower C, Blaiss MS, Jones SM. Allergic fungal sinusitis in children. Ann Allergy Asthma Immunol. 2006;96(2):286–90.\nGeorgalas C, Videler W, Freling N, Fokkens W. Global Osteitis Scoring Scale and chronic rhinosinusitis: a marker of revision surgery. Clin Otolaryngol. 2010;35(6):455–61.\nVideler WJ, Georgalas C, Menger DJ, Freling NJ, van Drunen CM, Fokkens WJ. Osteitic bone in recalcitrant chronic rhinosinusitis. Rhinology. 2011;49(2):139–47.\nSmith MJ. Evidence for the diagnosis and treatment of acute uncomplicated sinusitis in children: a systematic review. Pediatrics. 2013;132(1):e284–96.\nWald ER, Applegate KE, Bordley C, Darrow DH, Glode MP, Marcy SM, et al. Clinical practice guideline for the diagnosis and management of acute bacterial sinusitis in children aged 1 to 18 years. Pediatrics. 2013;132(1):e262–80.\nGallant JN, Basem JI, Turner JH, Shannon CN, Virgin FW. Nasal saline irrigation in pediatric rhinosinusitis: a systematic review. Int J Pediatr Otorhinolaryngol. 2018;108:155–62.\nHarvey R, Hannan SA, Badia L, Scadding G. Nasal saline irrigations for the symptoms of chronic rhinosinusitis. Cochrane Database Syst Rev. 2007;3. CD006394.\nChong LY, Head K, Hopkins C, Philpott C, Schilder AG, Burton MJ. Intranasal steroids versus placebo or no intervention for chronic rhinosinusitis. Cochrane Database Syst Rev. 2016;4 CD011996.\nChur V, Small CB, Stryszak P, Teper A. Safety of mometasone furoate nasal spray in the treatment of nasal polyps in children. Pediatr Allergy Immunol. 2013;24(1):33–8.\nRatner PH, Meltzer EO, Teper A. Mometasone furoate nasal spray is safe and effective for 1-year treatment of children with perennial allergic rhinitis. Int J Pediatr Otorhinolaryngol. 2009;73(5):651–7.\nGawchik S, Goldstein S, Prenner B, John A. Relief of cough and nasal symptoms associated with allergic rhinitis by mometasone furoate nasal spray. Ann Allergy Asthma Immunol. 2003;90(4):416–21.\nElwany S, El-Dine AN, El-Medany A, Omran A, Mandour Z, El-Salam AA. Relationship between bacteriology of the adenoid core and middle meatus in children with sinusitis. J Laryngol Otol. 2011;125(3):279–81.\nZuliani G, Carron M, Gurrola J, Coleman C, Haupert M, Berk R, et al. Identification of adenoid biofilms in chronic rhinosinusitis. Int J Pediatr Otorhinolaryngol. 2006;70(9):1613–7.\nBrietzke SE, Brigger MT. Adenoidectomy outcomes in pediatric rhinosinusitis: a meta-analysis. Int J Pediatr Otorhinolaryngol. 2008;72(10):1541–5.\nRamadan HH, Tiu J. Failures of adenoidectomy for chronic rhinosinusitis in children: for whom and when do they fail? Laryngoscope. 2007;117(6):1080–3.\nHebert RL 2nd, Bent JP 3rd. Meta-analysis of outcomes of pediatric functional endoscopic sinus surgery. Laryngoscope. 1998;108(6):796–9.\nChang PH, Lee LA, Huang CC, Lai CH, Lee TJ. Functional endoscopic sinus surgery in children using a limited approach. Arch Otolaryngol Head Neck Surg. 2004;130(9):1033–6.\nFetta M, Tsilis NS, Segas JV, Nikolopoulos TP, Vlastarakos PV. Functional endoscopic sinus surgery improves the quality of life in children suffering from chronic rhinosinusitis with nasal polyps. Int J Pediatr Otorhinolaryngol. 2017;100:145–8.\nVlastarakos PV, Fetta M, Segas JV, Maragoudakis P, Nikolopoulos TP. Functional endoscopic sinus surgery improves sinus-related symptoms and quality of life in children with chronic rhinosinusitis: a systematic analysis and meta-analysis of published interventional studies. Clin Pediatr. 2013;52(12):1091–7.\nSethi G, Chakravarti A. Quality of life after endoscopic sinus surgery in refractory pediatric chronic rhinosinusitis. Int J Pediatr Otorhinolaryngol. 2016;90:160–4.\nCriddle MW, Stinson A, Savliwala M, Coticchia J. Pediatric chronic rhinosinusitis: a retrospective review. Am J Otolaryngol. 2008;29(6):372–8.\nRamadan HH, Terrell AM. Balloon catheter sinuplasty and adenoidectomy in children with chronic rhinosinusitis. Ann Otol Rhinol Laryngol. 2010;119(9):578–82.\nRamadan HH, Cost JL. Outcome of adenoidectomy versus adenoidectomy with maxillary sinus wash for chronic rhinosinusitis in children. Laryngoscope. 2008;118(5):871–3.\nDon DM, Yellon RF, Casselbrant ML, Bluestone CD. Efficacy of a stepwise protocol that includes intravenous antibiotic therapy for the management of chronic sinusitis in children and adolescents. Arch Otolaryngol Head Neck Surg. 2001;127(9):1093–8.\nDeckard NA, Kruper GJ, Bui T, Coticchia J. Comparison of two minimally invasive techniques for treating chronic rhinosinusitis in the pediatric population. Int J Pediatr Otorhinolaryngol. 2011;75(10):1296–300.\nFerence EH, Schroeder JW Jr, Qureshi H, et al. Current utilization of balloon dilation versus endoscopic techniques in pediatric sinus surgery. Otolaryngol Head Neck Surg. 2014;151(5):852–60.\nChaaban MR, Rana N, Baillargeon J, Baillargeon G, Resto V, Kuo YF. Outcomes and complications of balloon and conventional functional endoscopic sinus surgery. Am J Rhinol Allergy. 2018:1945892418782248 This study offers a population-based comparison of complications and outcomes related to balloon sinuplasty and functional endoscopic sinus surgery.\nSoler ZM, Rosenbloom JS, Skarada D, Gutman M, Hoy MJ, Nguyen SA. Prospective, multicenter evaluation of balloon sinus dilation for treatment of pediatric chronic rhinosinusitis. Int Forum Allergy Rhinol. 2017;7(3):221–9.\nLiu J, Zhao Z, Chen Y, Xu B, Dai J, Fu Y. Clinical curative effect and safety of balloon sinuplasty in children with chronic rhinosinusitis. Int J Pediatr Otorhinolaryngol. 2017;100:204–10.\nHouse LK, Lewis AF, Ashmead MG. A cost-effectiveness analysis of the up-front use of balloon catheter dilation in the treatment of pediatric chronic rhinosinusitis. Am J Otolaryngol. 2018;39(4):418–22.",{"VOID":198},"10.1007\u002Fs40746-018-0142-z","2024-05-07T12:26:23.577+00:00","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs40746-018-0142-z",[202,217],{"id":203,"sortIndex":19,"researcher":18,"roles":204,"affiliations":205,"properties":214,"displayName":216,"givenName":18,"familyName":18},"418f5f6d-bb7f-4e65-a0eb-d08bf1b2eea6",[117],[206],{"id":207,"sortIndex":19,"affiliation":208,"properties":18},"3053e9fd-3b25-47c2-8875-1b54c66b43b2",{"id":207,"createTime":18,"updateTime":18,"relativeEntities":209,"slug":18,"properties":210,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":213,"statistic":18},[],{"title":211},{"VI":212},"Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, USA",[],{"title":215},{"VI":216},"Lourdes Quintanilla-Dieck",{"id":218,"sortIndex":65,"researcher":18,"roles":219,"affiliations":220,"properties":227,"displayName":229,"givenName":18,"familyName":18},"a2f77ef5-5822-4a89-97d0-6a0b91b48c20",[117],[221],{"id":207,"sortIndex":19,"affiliation":222,"properties":18},{"id":207,"createTime":18,"updateTime":18,"relativeEntities":223,"slug":18,"properties":224,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":226,"statistic":18},[],{"title":225},{"VI":212},[],{"title":228,"gsAuthor":230},{"VI":229},"Derek J. Lam",{"VOID":231},"[\"o_wt590AAAAJ\"]",{"url":200,"publisher":233,"properties":262},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":234,"slug":10,"properties":235,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":238,"manageAffiliations":243,"indexDatabases":249,"url":54,"thumbnailPath":18,"statistic":257,"gsStatistic":18,"type":86,"analyzePriority":18},[],{"issn":236,"title":237},{"VOID":13},{"EN":15},[239],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":240,"label":241,"description":242,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[244],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":245,"slug":18,"properties":246,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":248,"statistic":18},[],{"title":247},{"EN":33},[35],[250],{"id":38,"indexDatabase":251,"url":49,"indexYears":50,"academicFieldIds":256,"indexDatabaseRanking":53},{"id":40,"createTime":18,"updateTime":18,"relativeEntities":252,"label":253,"description":254,"key":46,"publicationTags":255,"standard":18},[],{"EN":43,"VI":43},{"EN":43,"VI":45},[48],[52],{"impactFactor":19,"impactFactorByYear":258,"i10Index":62,"i10IndexLast5Year":62,"totalPublication":63,"totalPublicationByYear":259,"totalCitation":74,"totalCitationByYear":260,"totalCitationPerPublication":80,"totalCitationPerPublicationByYear":261,"hindexLast5Year":76,"hindex":76},{"2017":57,"2020":58,"2021":59,"2022":60,"2023":61},{"2014":65,"2015":66,"2016":67,"2017":68,"2018":69,"2019":70,"2020":71,"2021":72,"2022":73,"2023":72},{"2015":76,"2016":77,"2018":65,"2019":78,"2020":79,"2021":76},{"2015":82,"2016":83,"2018":57,"2019":84,"2020":85,"2021":80},{"pages":263,"volume":265},{"VOID":264},"413-424",{"VOID":266},"4",{"total":19,"publishYear":268,"statisticByYear":269},2018,{},"2018-09-25","2026-06-21T20:30:45.764+00:00",[],{"id":274,"createTime":275,"updateTime":276,"relativeEntities":277,"slug":278,"properties":279,"entityType":108,"verifyStatus":109,"verifyTime":288,"verifyNote":111,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":289,"fullTextUrl":18,"authors":290,"publicationType":139,"publisherRelationship":321,"citationCount":18,"citationInfo":18,"publishDate":356,"publishYear":357,"citationAnalyzeStatus":17,"lastCitationAnalyze":276,"indexDatabases":358,"openAccess":18,"references":359,"isForceReanalyzing":181},"a3102022-e18c-43cb-8046-88466ff3e794","2024-02-09T15:54:28.458+00:00","2025-06-24T11:38:56.356+00:00",[],"Improving-the-Quality-of-Pediatric-Healthcare-through-Quality-Improvement-Collaboratives",{"abstract":280,"title":282,"gsPaper":284,"doi":286},{"EN":281},"\n                        Purpose of review This review summarizes the current need for Quality Improvement Collaboratives (QICs) and includes considerations specific to pediatric healthcare, such as low-frequency of outcomes and unique funding barriers. This review will consider nuances within measure formation and data collection within QICs, available models for structured formation of a QIC, components that are integral to a QICs success, as well as lessons learned and future directions.Recent findings The literature has demonstrated an increase in the number of pediatric QI collaboratives in recent years. These collaboratives have varied in size, duration, and composition of team members. While some QICs have included members at the organizational level, others have included more novel groups such as insurance companies. Novel methodologies have also been utilized such as N of 1 trials focused on continued interventions for one patient and provider dyad. Successful QICs include use of a steering committee or pre-planning group to guide measures development, use of robust QI methodology to implement small tests of change and continuous feedback of individual and aggregate data and transparency among benchmarking sites. Ideal QI methods for use within QICs have been vetted in prior collaboratives and include formal barriers assessments using driver diagrams, PDSA cycles and analyzing data and measures using run and statistical process control (SPC) charts to inform real-time change and interventions.Summary QICs are pivotal to closing the gap in delivery of evidence based practice while minimizing widespread unnecessary practice variation across multiple organizations using available QI methodologies and tools. Novel approaches to funding such as partnership with insurance companies and educational organizations can allow for more robust participation. Future research should broaden the scope of their measures to include patient centered outcomes.",{"EN":283},"Improving the Quality of Pediatric Healthcare through Quality Improvement Collaboratives",{"VOID":285},"[\"1842160138859292100\"]",{"VOID":287},"10.1007\u002Fs40746-017-0105-9","2024-04-30T20:57:47.418+00:00","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs40746-017-0105-9",[291,306],{"id":292,"sortIndex":19,"researcher":18,"roles":293,"affiliations":294,"properties":303,"displayName":305,"givenName":18,"familyName":18},"ed9093e4-1a18-4d48-bb41-6a8eb2f37d25",[117],[295],{"id":296,"sortIndex":19,"affiliation":297,"properties":18},"7a19fe0a-bb94-4df8-9457-cbc3c0abaa28",{"id":296,"createTime":18,"updateTime":18,"relativeEntities":298,"slug":18,"properties":299,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":302,"statistic":18},[],{"title":300},{"VI":301},"Division of Emergency Medicine and Center for Excellence, Ann and Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, USA",[],{"title":304},{"VI":305},"Raina Paul",{"id":307,"sortIndex":65,"researcher":18,"roles":308,"affiliations":309,"properties":318,"displayName":320,"givenName":18,"familyName":18},"4384130d-151a-48a7-a2de-44eb2c75b286",[117],[310],{"id":311,"sortIndex":19,"affiliation":312,"properties":18},"ad8bbb0d-2d95-46f4-85fe-cb405f2dea32",{"id":311,"createTime":18,"updateTime":18,"relativeEntities":313,"slug":18,"properties":314,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":317,"statistic":18},[],{"title":315},{"VI":316},"Division of Cardiology and Center for Excellence, Ann and Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, USA",[],{"title":319},{"VI":320},"George R. Verghese",{"url":289,"publisher":322,"properties":351},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":323,"slug":10,"properties":324,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":327,"manageAffiliations":332,"indexDatabases":338,"url":54,"thumbnailPath":18,"statistic":346,"gsStatistic":18,"type":86,"analyzePriority":18},[],{"issn":325,"title":326},{"VOID":13},{"EN":15},[328],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":329,"label":330,"description":331,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[333],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":334,"slug":18,"properties":335,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":337,"statistic":18},[],{"title":336},{"EN":33},[35],[339],{"id":38,"indexDatabase":340,"url":49,"indexYears":50,"academicFieldIds":345,"indexDatabaseRanking":53},{"id":40,"createTime":18,"updateTime":18,"relativeEntities":341,"label":342,"description":343,"key":46,"publicationTags":344,"standard":18},[],{"EN":43,"VI":43},{"EN":43,"VI":45},[48],[52],{"impactFactor":19,"impactFactorByYear":347,"i10Index":62,"i10IndexLast5Year":62,"totalPublication":63,"totalPublicationByYear":348,"totalCitation":74,"totalCitationByYear":349,"totalCitationPerPublication":80,"totalCitationPerPublicationByYear":350,"hindexLast5Year":76,"hindex":76},{"2017":57,"2020":58,"2021":59,"2022":60,"2023":61},{"2014":65,"2015":66,"2016":67,"2017":68,"2018":69,"2019":70,"2020":71,"2021":72,"2022":73,"2023":72},{"2015":76,"2016":77,"2018":65,"2019":78,"2020":79,"2021":76},{"2015":82,"2016":83,"2018":57,"2019":84,"2020":85,"2021":80},{"pages":352,"volume":354},{"VOID":353},"362-373",{"VOID":355},"3","2017-11-20",2017,[53],[360,364,370,373,376,379,382,385,388,391,394,397,400,408,411,420,423,429,432,435,439,443,447,450,453,457,461,465,468,471,474,477],{"id":18,"text":361,"url":362,"identifiers":363},"Miller MR, Niedner MF, Huskins WC, et al. National Association of Children’s Hospitals and Related Institutions Pediatric Intensive Care Unit Central Line-Associated Bloodstream Infection Quality Transformation Teams. Reducing PICU central line-associated bloodstream infections: 3-year results. Pediatrics. 2011;128(5). Available at: www.pediatrics.org\u002Fcgi\u002Fcontent\u002Ffull\u002F128\u002F5\u002Fe1077.","www.pediatrics.org\u002Fcgi\u002Fcontent\u002Ffull\u002F128\u002F5\u002Fe1077",{},{"id":365,"text":366,"url":367,"identifiers":368},"4c68646b-0035-4279-8000-0006b275d4fa","Blumenthal A. The stories behind the stats: NACHRI quality transformation network reaches milestone. Pediatr Nurs. 2011;37(5):276–8. 3. Ohio Children’s Hospitals Solutions for Patient Safety. Available at: http:\u002F\u002Fsolutionsforpatientsafety.org\u002F. Accessed 4 April 2013","https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs10440-022-00541-7",{"doi":369},"10.1007\u002Fs10440-022-00541-7",{"id":365,"text":371,"url":367,"identifiers":372},"Watson RS, Carcillo JA, Linde-Zwirble WT, et al. The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med. 2003;167(5):695–701.",{"doi":369},{"id":365,"text":374,"url":367,"identifiers":375},"Cameron DB, Rangel S. Quality improvement in pediatric surgery. J Curr Opin Pediatr. 2016;28(3):348–55.",{"doi":369},{"id":18,"text":377,"url":18,"identifiers":378},"Wennberg JE. Dartmouth Atlas of Health Care. Available at: www.dartmouthatlas.org. Practice variation: implications for our health care system. Manag Care. 2004;13(supplement 9):3–7.",{},{"id":18,"text":380,"url":18,"identifiers":381},"Committee on Quality of Health Care in America and the Institute of Medicine, Crossing the Quality Chasm; 2001.",{},{"id":18,"text":383,"url":18,"identifiers":384},"Substance Abuse and Mental Health Services Administration Bulletin; Rockland. 2012. www.Samhsa.gov.",{},{"id":18,"text":386,"url":18,"identifiers":387},"Children’s Hospital Association webpage: www.childrenshospitals.org\u002FAbout-Us\u002FAbout-the-Association.",{},{"id":18,"text":389,"url":18,"identifiers":390},"•• Miles PV, Conway PH, Pawlson G. Physician professionalism and accountability: the role of collaborative improvement networks. Pediatrics. 2013;131(Supplement 4):S204–9. This seminal manuscript details how Quality Improvement Collaboratives and Networks can add tremendous value to multiple stakeholders in the healthcare area and postulates strategies to ensure onoing collaborative work.",{},{"id":18,"text":392,"url":18,"identifiers":393},"Institute for Healthcare Improvement. The breakthrough series: IHI’s collaborative model for achieving breakthrough improvement. IHI Innovation series white paper. Boston; 2003.",{},{"id":18,"text":395,"url":18,"identifiers":396},"Kilo CM. A framework for collaborative improvement: lessons from the institute for healthcare improvement’s breakthrough series. Qual Manag Health Care Summer. 1998;6(4):1–14.",{},{"id":365,"text":398,"url":367,"identifiers":399},"Mistry KP, Jaggers J, Lodge A. Using six sigma methodology to improve handoff communication in high risk patients. In: Henriksen K, Battles JB, Keyes MA, et al., editors. Advances in patient safety; new directions and alternative approaches (Vol 3: Performance and tools). Rockville: Agency for Healthcare Research and Quality; 2008.",{"doi":369},{"id":18,"text":401,"url":402,"identifiers":403},"Horbar JD, Rogowski J, Plesek P, et al. Collaborative quality improvement for neonatal intensive care. Pediatrics. 107(1):14–22. https:\u002F\u002Fdoi.org\u002F10.1542\u002Fpeds.107.1.14.","https:\u002F\u002Fdoi.org\u002F10.1542\u002Fpeds.107.1.14",{"mag":404,"openalex":405,"pm":406,"doi":407},"1972732693","W1972732693","11134428","10.1542\u002Fpeds.107.1.14",{"id":18,"text":409,"url":18,"identifiers":410},"Sundberg M,Paul R, Verghese G. Teamwork and Collaboration. Patient safety and quality in pediatric hematology\u002Foncology and stem cell transplantation; 2017.",{},{"id":18,"text":412,"url":413,"identifiers":414},"Berwick DM. A primer on leading the improvement of systems. BMJ. 1996;312(7031):619–22. https:\u002F\u002Fdoi.org\u002F10.1136\u002Fbmj.312.7031.619.","https:\u002F\u002Fdoi.org\u002F10.1136\u002Fbmj.312.7031.619",{"mag":415,"pmc":416,"openalex":417,"pm":418,"doi":419},"2058036013","2350403","W2058036013","8595340","10.1136\u002Fbmj.312.7031.619",{"id":18,"text":421,"url":18,"identifiers":422},"Langley G, Moen R, Nolan K, et al. The improvement guide: a practical approach to enhancing organizational performance. 2nd ed. San Francisco: Jossey-Bass; 2009.",{},{"id":424,"text":425,"url":426,"identifiers":427},"d6428d5b-a574-45c8-986c-38122e1a679f","Schouten LMT, Grol RP, Hulscher ME. Factors influencing success in quality improvement Collaboratives: development and psychometric testing of an instrument. Implement Sci. 2010;5(1):1–9.","https:\u002F\u002Fimplementationscience.biomedcentral.com\u002Farticles\u002F10.1186\u002F1748-5908-5-84",{"doi":428},"10.1186\u002F1748-5908-5-84",{"id":18,"text":430,"url":18,"identifiers":431},"• Erum NS, Serene O, et al. Understanding the components of quality improvement Collaboratives: a systematic literature review. Milbank Q. 2013;91(2):354–94. This manuscript details in robust manner the potential components of successful QI collaboratives. It details the latest collaboratives in both pediatrics and adults and attempts to link successful components to outcomes, a novel approach.",{},{"id":18,"text":433,"url":18,"identifiers":434},"Langley GL, Moen R, Nolan KM, Nolan TW, Norman CL, Provost LP. The improvement guide: a practical approach to enhancing organizational performance. 2nd ed. San Francisco: Jossey-Bass Publishers; 2009.",{},{"id":18,"text":436,"url":437,"identifiers":438},"National Pediatric Cardiology Quality Improvement Collaborative. For parents by parents http:\u002F\u002Fjcchdqi.org\u002Fparents; 2012.","http:\u002F\u002Fjcchdqi.org\u002Fparents",{},{"id":18,"text":440,"url":441,"identifiers":442},"Families. Improve Care Now. https:\u002F\u002Fimprovecarenow.org\u002Ffamilies; 2012.","https:\u002F\u002Fimprovecarenow.org\u002Ffamilies",{},{"id":18,"text":444,"url":445,"identifiers":446},"Collaborative Chronic Care Network. N of 1 trials. http:\u002F\u002Fc3nproject.org\u002Finnovations\u002Fn-1-trials. 2012.","http:\u002F\u002Fc3nproject.org\u002Finnovations\u002Fn-1-trials",{},{"id":18,"text":448,"url":18,"identifiers":449},"Anderson JB, Beekman R, Kugler JD. Improvement in interstage survival in a national pediatric cardiology learning network: for the national pediatric cardiology quality improvement collaborative. Circ Cardiovasc Qual Outcomes. 2015;8:428–36.",{},{"id":365,"text":451,"url":367,"identifiers":452},"Adirim T, Kelley MKamila M et al. A new era in quality measurement: the development and application of quality measures. Pediatrics. 2017; 139(1).",{"doi":369},{"id":18,"text":454,"url":455,"identifiers":456},"Pediatric Health Information System. Children’s Hospital Association. Available at: http:\u002F\u002Fwww.childrenshospitals.org. Accessed 31 Oct 2012.","http:\u002F\u002Fwww.childrenshospitals.org",{},{"id":18,"text":458,"url":459,"identifiers":460},"Agency for Healthcare Research and Quality. Grants on-line database. Factors Associated with Quality of Care Delivered to Children in US EDs. Available at: http:\u002F\u002Fgold.ahrq.gov\u002Fprojectsearch\u002Fgrant_summary.jsp?grant¼R01þHS19712-03. Accessed 3 Oct 2017. 36.","http:\u002F\u002Fgold.ahrq.gov\u002Fprojectsearch\u002Fgrant_summary.jsp?grant¼R",{},{"id":18,"text":462,"url":463,"identifiers":464},"Agency for Healthcare Research and Quality. Grants on-line database. Improving the Quality of Pediatric Emergency Care Using an Electronic Medical Record. Available at: http:\u002F\u002Fgold.ahrq.gov\u002Fprojectsearch\u002Fgrant_summary.jsp?grant¼R01þHS20270-02. Accessed 2 Oct 2017. 37.","http:\u002F\u002Fgold.ahrq.gov\u002Fprojectsearch\u002Fgrant_summary.jsp?",{},{"id":365,"text":466,"url":367,"identifiers":467},"Agency for Healthcare Research and Quality. Grants on-line database. ParentLink: Better and Safer Emergency Care for Children. Available at: http:\u002F\u002Fgold.ahrq.gov\u002Fprojectsearch\u002Fgrant_summary.jsp?grant¼R01þHS14947-02. Accessed 3 Oct 2017.",{"doi":369},{"id":365,"text":469,"url":367,"identifiers":470},"Miller M, Wietecha M. Keeping children healthy. Fresh approaches are sorely needed to expand pediatric HAI prevention efforts. Mod Healthc. 2012;42(1):22.",{"doi":369},{"id":18,"text":472,"url":18,"identifiers":473},"Grades of Recommendation, Oxford Centre for Evidence Based Medicine. Available at: www.cebm.net\u002Findex.aspx?o=1047. Accessed 1 Oct 2017.",{},{"id":18,"text":475,"url":18,"identifiers":476},"Dougherty D, Conway PH. The 3 Ts roadmap to transform U.S. healthcare: the “how” of high-quality care. JAMA. 2008;299(19):2319–21.",{},{"id":365,"text":478,"url":367,"identifiers":479},"Clancy C, Margolis P, Miller M. Collaborative networks for both improvement and research. Pediatrics. 2013;13(Supplement 4):S210–4.",{"doi":369},{"id":481,"createTime":482,"updateTime":483,"relativeEntities":484,"slug":485,"properties":486,"entityType":108,"verifyStatus":109,"verifyTime":483,"verifyNote":111,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":495,"fullTextUrl":18,"authors":496,"publicationType":139,"publisherRelationship":584,"citationCount":18,"citationInfo":18,"publishDate":618,"publishYear":176,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":619,"openAccess":18,"references":18,"isForceReanalyzing":181},"e819b6eb-880f-4122-b4b9-35fff411ab81","2023-12-14T11:34:00.686+00:00","2025-02-26T02:28:34.817+00:00",[],"Change-Management-in-Quality-Improvement-The-Softer-Skills",{"abstract":487,"title":489,"references":491,"doi":493},{"EN":488},"Quality improvement work in healthcare requires an understanding of not only the methodology and science of improvement but also a mastery of the concepts of change management. These “softer skills” include leadership, team building, culture, context, and patient and family engagement. Capable leaders and teams facilitate improvement by fostering a culture of improvement. By engaging patients and families, interventions and innovations can be appropriately tailored to suit individual contexts. Without the incorporation of these change management concepts, successful, sustainable quality improvement cannot be achieved.",{"EN":490},"Change Management in Quality Improvement: The Softer Skills",{"VOID":492},"Reinertsen JL, Bisognano M, Pugh MD. Seven Leadership Leverage Points for Organization-Level Improvement in Health Care (Second Edition). IHI Innovation Series white paper. Cambridge, MA: Institute for Healthcare Improvement; 2008. (Available on www.IHI.org) This article provides an overview of the key points for leaders who want to facilitate QI in their organizations. It is an excellent summary of the necessary characteristics for anyone wishing to lead organizational change.\nMcAlearney AS. Using leadership development programs to improve quality and efficiency in healthcare. J Healthcare Manag. 2008;53:319–31. This article describes the ways in which leadership development programs improve quality and efficiency in healthcare and provides qualitative evidence that leadership development contributes to improvement efforts.\nLee TH. Turning doctors into leaders. Harv Bus Rev. 2010;88:50–8.\nHomer CS, Friberg IK, Dias MA, et al. The projected effect of scaling up midwifery. Lancet. 2014;384:1146–57.\nFrich JC, Brewster AL, Cherlin EJ, Bradley EH. Leadership development programs for physicians: a systematic review. J Gen Int Med. 2015;30:656–74.\nCrossing the quality chasm: a new health system for the 21st century. Institute of Medicine Committee on Health Care in America. Washington (DC): National Academies Press; 2001. This work describes the gaps in care in our current health care system in the United States and provides insight into each of the “softer” QI skills as they relate to heath care transformation.\nBohmer RM. Managing the new primary care: the new skills that will be needed. Health Aff. 2010;29:1010–4. This article provides an excellent summary of the need to foster leadership and change management skills in primary care physicians in order for physicians to remain effective caregivers in the new primary care models.\nMiles PV, Moyer VA. Quality improvement and maintenance of certification. Acad Pediatr. 2013;13:S15.\nTing HH, Nowick KM, Starr SR, et al., Integrating maintenance of certification programs and health systems’ quality-improvement programs. Harvard Bus Rev. 2013. November.\nEllner AL, Stout S, Sullivan EE, Griffiths EP, Mountjoy A, Phillips RS. Health systems innovation at academic health centers: leading in a new era of health care delivery. Acad Med. 2015, March 2. Epub ahead of print. This article reviews the current metrics for achieving promotion in academic health centers and highlights the need for better defined pathways to promotion for physicians who pursue careers in health systems transformation.\nScholtes PR, Joiner BL, Streibel, BJ. The Team Handbook, 3rd edition. Edison, NJ: Oriel STAT A MATRIX; 2010. This is a textbook with practical step-by-step instructions for development of self-sustaining and productive teams. It is a necessity for any individual beginning improvement work.\nPorter ME. What is value in health care? N Engl J Med. 2010;363:2477–81. This article helps establish a framework for improving outcomes while reducing costs. It emphasizes the importance of selecting outcomes that are meanigful to both healthcare providers and patients in an effort to truly promote value in healthcare.\nBritto MT, Vockell AB, Munafo JK, Schoettker PJ, Wimberg JA, Pruett R, et al. Improving outcomes for underserved adolescents with asthma. Pediatrics. 2014;133(2):e418–427.\nBodenheimer T, Wagner EH, Grumbach K. Improving primary care for patients with chronic illness. JAMA. 2002;288(14):1775–9.\nDetert JR, Schroeder RG, Mauriel JJ. A framework for linking culture and improvement initiatives in organizations. Acad Manag Rev. 2000;25(4):850–63.\nPettigrew A. The awakening giant: change and continuity in ICI. Oxford: Blackwell; 1998.\nSecretary of State for Health. The new NHS modern and dependable: a national framework for assessing Performance. London. HMSO; 1998.\nShortell SM, Bennet CL, Byck GR. Assessing the impact of continuous quality improvement on clinical practice: what it will take. Milibank Q. 1998;76(4):593–624.\nBerwick DM. A user’s manual for the IOM’s ‘Quality Chasm’ report. Health Aff. 2002;21(3):80–90. This is an essential “how to” for healthcare providers involved with quality improvement. It provides guidance and a “true north” for the healthcare providers of the next century.\nDavies HTO, Nutley SM, Mannion R. Organisational culture and quality of health care. Quality Health Care. 2000;9:111–9.\nShortell SM, O’Brien JM. Carman, et al. Assessing the impact of continuous quality improvement\u002Ftotal quality management: concept versus implementation. Health Serv Res. 1995;30(2):377–401.\nShortell SM, Gilles RR, Anderson DA, et al. Remaking health care in America. San Francisco: Jossey-Bass; 1996.\nPathman DE, Konrad TR, Freed GL, et al. The awareness-to-adherence model of the steps to clinical guidelines compliance. The case of pediatric vaccine recommendations. Med Care. 1996;34:873–89.\nSolomons NM, Spross JA. Evidence-based practice barriers and facilitators from continuous quality improvement perspective: an integrative review. J Nursing Manag. 2011;19:109–20.\nGreenhalgh T, Robert G, Macfarlane F, Bate F, Kyriakidou O. Diffusion of innovations in service organizations: systematic review and recommendations. Milbank Q. 2004;82(4):581–629.\nLangley GI, Moen RD, Nolan KM, Nolan TW, Norman CL, Provost LP. The improvement guide. San Francisco: Jossey-Boss; 2009.\nEdwards N, Barker PM. The importance of context in implementation research. J Acquir Immune Defic Syndr. 2014;67(S2):S157–162. This article describes the importance of context in achieving successful implementation of complex interventions to decrease mother to child transmission of HIV in South Africa. The authors provide an excellent overview of the importance of contextual characteristics in QI work.\nMaurer M, Dardess P, Carman KL, et al. Guide to patient and family engagement: environmental scan report. AHRQ. Rockville, MD. Agency for Healthcare and Research Quality, 2012.\nDomecq JP, Prtusky G, Elraiya T, et al. Patient engagement in research: a systematic review. BMC Health Serv Res. 2014;14:89.\nShippee ND, Shah ND, May CR, Mair FS, Montori VM. Cumulative complexity: a functional, patient-centered model of patient complexity can improve research and practice. J of Clin Epi. 2012;65:1041–51.\nStacey D, Bennett, CL, Barry MJ, et al. Decision aids for people facing health treatment or screening decisions. The Cochrane, Database. 2011;CD001413.\nParker RM, Wolf MS, Kirsch I. Preparing for an epidemic of limited health literacy: weathering the perfect storm. J of Gen Int Med. 2008;23:1273–6.\nMay C, Montori VM, Mair FS. We need minimally disruptive medicine. BMJ. 2009;339:b2803.",{"VOID":494},"10.1007\u002Fs40746-015-0028-2","http:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs40746-015-0028-2",[497,521,536,560],{"id":498,"sortIndex":19,"researcher":18,"roles":499,"affiliations":500,"properties":518,"displayName":520,"givenName":18,"familyName":18},"f358e83f-9248-4690-9524-b4096a6577a1",[117],[501,509],{"id":502,"sortIndex":19,"affiliation":503,"properties":18},"7fb0d600-7d37-4601-87a4-bc2a0a037ac7",{"id":502,"createTime":18,"updateTime":18,"relativeEntities":504,"slug":18,"properties":505,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":508,"statistic":18},[],{"title":506},{"VI":507},"Division of Pediatric Otolaryngology—Head and Neck Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, USA",[],{"id":510,"sortIndex":65,"affiliation":511,"properties":517},"5562bbc5-f952-4d98-87ad-3ed75cf8c8c6",{"id":510,"createTime":18,"updateTime":18,"relativeEntities":512,"slug":18,"properties":513,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":516,"statistic":18},[],{"title":514},{"VI":515},"Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, USA",[],{},{"title":519},{"VI":520},"Catherine K. Hart",{"id":522,"sortIndex":65,"researcher":18,"roles":523,"affiliations":524,"properties":533,"displayName":535,"givenName":18,"familyName":18},"680a7835-e76e-4f04-94d5-c6372a9f02c2",[117],[525],{"id":526,"sortIndex":19,"affiliation":527,"properties":18},"4b956be5-ceca-4bb3-af20-9707c572ab8c",{"id":526,"createTime":18,"updateTime":18,"relativeEntities":528,"slug":18,"properties":529,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":532,"statistic":18},[],{"title":530},{"VI":531},"Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, USA",[],{"title":534},{"VI":535},"Chelly Dykes",{"id":537,"sortIndex":62,"researcher":18,"roles":538,"affiliations":539,"properties":557,"displayName":559,"givenName":18,"familyName":18},"864427eb-7415-43d9-ba83-a433422865ed",[117],[540,548],{"id":541,"sortIndex":19,"affiliation":542,"properties":18},"4c31478e-e923-4602-b3bf-37a5ee08268f",{"id":541,"createTime":18,"updateTime":18,"relativeEntities":543,"slug":18,"properties":544,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":547,"statistic":18},[],{"title":545},{"VI":546},"Department of Anesthesiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, USA",[],{"id":549,"sortIndex":65,"affiliation":550,"properties":556},"079ff75d-a75c-40df-abc2-9bb5352a86bb",{"id":549,"createTime":18,"updateTime":18,"relativeEntities":551,"slug":18,"properties":552,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":555,"statistic":18},[],{"title":553},{"VI":554},"Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, USA",[],{},{"title":558},{"VI":559},"Rachel Thienprayoon",{"id":561,"sortIndex":79,"researcher":18,"roles":562,"affiliations":563,"properties":581,"displayName":583,"givenName":18,"familyName":18},"57f372d1-033c-4f1d-b4a8-ddc83ded1b20",[117],[564,572],{"id":565,"sortIndex":19,"affiliation":566,"properties":18},"12e1fbf4-d62c-4418-8963-0e6ea31af698",{"id":565,"createTime":18,"updateTime":18,"relativeEntities":567,"slug":18,"properties":568,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":571,"statistic":18},[],{"title":569},{"VI":570},"Department of Occupational and Physical Therapy, Cincinnati Children’s Hospital Medical Center, Cincinnati, USA",[],{"id":573,"sortIndex":65,"affiliation":574,"properties":580},"fc61248a-a7d6-4478-8882-aa5d7a1d7b34",{"id":573,"createTime":18,"updateTime":18,"relativeEntities":575,"slug":18,"properties":576,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":579,"statistic":18},[],{"title":577},{"VI":578},"Department of Rehabilitation Services, Cincinnati Children’s Hospital Medical Center, Cincinnati, USA",[],{},{"title":582},{"VI":583},"Jennifer Schmit",{"url":495,"publisher":585,"properties":614},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":586,"slug":10,"properties":587,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":590,"manageAffiliations":595,"indexDatabases":601,"url":54,"thumbnailPath":18,"statistic":609,"gsStatistic":18,"type":86,"analyzePriority":18},[],{"issn":588,"title":589},{"VOID":13},{"EN":15},[591],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":592,"label":593,"description":594,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[596],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":597,"slug":18,"properties":598,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":600,"statistic":18},[],{"title":599},{"EN":33},[35],[602],{"id":38,"indexDatabase":603,"url":49,"indexYears":50,"academicFieldIds":608,"indexDatabaseRanking":53},{"id":40,"createTime":18,"updateTime":18,"relativeEntities":604,"label":605,"description":606,"key":46,"publicationTags":607,"standard":18},[],{"EN":43,"VI":43},{"EN":43,"VI":45},[48],[52],{"impactFactor":19,"impactFactorByYear":610,"i10Index":62,"i10IndexLast5Year":62,"totalPublication":63,"totalPublicationByYear":611,"totalCitation":74,"totalCitationByYear":612,"totalCitationPerPublication":80,"totalCitationPerPublicationByYear":613,"hindexLast5Year":76,"hindex":76},{"2017":57,"2020":58,"2021":59,"2022":60,"2023":61},{"2014":65,"2015":66,"2016":67,"2017":68,"2018":69,"2019":70,"2020":71,"2021":72,"2022":73,"2023":72},{"2015":76,"2016":77,"2018":65,"2019":78,"2020":79,"2021":76},{"2015":82,"2016":83,"2018":57,"2019":84,"2020":85,"2021":80},{"pages":615,"volume":617},{"VOID":616},"372-379",{"VOID":174},"2015-09-29",[53],{"id":621,"createTime":622,"updateTime":623,"relativeEntities":624,"slug":625,"properties":626,"entityType":108,"verifyStatus":109,"verifyTime":623,"verifyNote":111,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":635,"fullTextUrl":18,"authors":636,"publicationType":139,"publisherRelationship":667,"citationCount":18,"citationInfo":18,"publishDate":702,"publishYear":703,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":704,"openAccess":18,"references":18,"isForceReanalyzing":181},"01c98824-5c52-4dbb-b4be-2bc4d26604ea","2024-01-13T03:36:31.047+00:00","2025-02-26T00:10:26.261+00:00",[],"Pediatric-Inflammatory-Neck-Mass",{"abstract":627,"title":629,"references":631,"doi":633},{"EN":628},"The treatment of pediatric inflammatory neck masses depends upon the underlying etiology and may include both medical and surgical interventions. The most common causes of bacterial cervical lymphadenitis include Staphylococcus aureus (increasingly methicillin-resistant S. aureus), and Streptococcus pyogenes. A contrast-enhanced computed tomography (CT) scan can provide an accurate means of diagnosing whether an abscess is present which might need surgical drainage. Recent studies, however, have focused on the ability to diagnose abscesses using imaging studies that limit the patient exposure to radiation, including the use of ultrasound, magnetic resonance imaging (MRI) and low-voltage CT scanning. Recent database studies have demonstrated trends in the incidence and management of deep neck abscesses from 2000 to 2009. The incidence of retropharyngeal abscesses has increased while the incidence of peritonsillar abscesses, parapharyngeal abscesses or combined space deep neck infections has remained the same. Rates of incision and drainage for retropharyngeal abscesses have decreased, while for peritonsillar abscesses rates of incision and drainage have increased with a corresponding decrease in tonsillectomy rates. Fusobacterial infections have been associated with peritonsillar abscesses and deep neck space infections in association with Lemierre syndrome. These infections are treated with culture-directed antibiotics and surgical drainage when indicated and the prognosis is generally good when identified early. Kawasaki disease (KD) is a potential non-infectious\u002Fidiopathic cause of inflammatory pediatric neck mass. In addition to cervical lymphadenopathy, patients with Kawasaki disease may present with retropharyngeal cellulitits or abscess. It is critical that the patient with KD be identified within 10 days of illness onset so the child can be treated with intravenous immunoglobulin which has unequivocally been shown to decrease the incidence of potentially life-threatening cardiac aneurysms.",{"EN":630},"Pediatric Inflammatory Neck Mass",{"VOID":632},"Delides A, Manoli E, Papadopoulos M, Nikolopoulos T. Ultrasound-guided transoral drainage of a paediatric parapharyngeal abscess. J Laryngol Otol. 2014;128:1120–2.\nScholtz J-E et al. Evaluation of image quality and dose reduction of 80 kVp neck computed tomography in patients with suspected peritonsillar abscess. Clin Radiol. 2015;70:e67–73. Describes the diagnostic accuracy and improved clarity of low voltage CT scans in diagnosing peritonsillar abscess. This could potentially be easily adopted more broadly in clinical use and result in reduced radiation exposure.\nCollins B, Stoner J a, Digoy GP. Benefits of ultrasound vs. computed tomography in the diagnosis of pediatric lateral neck abscesses. Int J Pediatr Otorhinolaryngol. 2014;78:423–6. Describes the diagnostic accuracy of ultrasound as an alternative to CT scanning in deep neck abscesses.\nSaat R et al. MR imaging features of acute mastoiditis and their clinical relevance. AJNR Am J Neuroradiol. 2015;36:361–7.\nBrenner DJ. Should we be concerned about the rapid increase in CT usage? Rev Environ Health 25:63–8.\nPearce MS et al. Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Lancet (London, England). 2012;380:499–505. Highlights the risks associated with CT scans due to radiation exposure.\nWichmann JL et al. Low-tube-voltage 80-kVp neck CT: evaluation of diagnostic accuracy and interobserver agreement. AJNR Am J Neuroradiol. 2014;35:2376–81.\nNeff L, Newland JG, Sykes KJ, Selvarangan R, Wei JL. Microbiology and antimicrobial treatment of pediatric cervical lymphadenitis requiring surgical intervention. Int J Pediatr Otorhinolaryngol. 2013;77:817–20.\nWalker PC, Karnell LH, Ziebold C, Kacmarynski DSF. Changing microbiology of pediatric neck abscesses in Iowa 2000–2010. Laryngoscope. 2013;123:249–52.\nWorley ML et al. Suppurative cervical lymphadenitis in infancy: microbiology and sociology. Clin Pediatr (Phila). 2015;54:629–34. Important review of current bacteriology of infant neck abscesses.\nCheng J, Elden L, Elden L. Children with deep space neck infections: our experience with 178 children. Otolaryngol Head Neck Surg. 2013;148:1037–42. Important review of current bacteriology of pediatric neck abscesses.\nMutlu M, Dereci S, Aslan Y. Deep neck abscess in neonatal period: case report and review of literature. Int J Pediatr Otorhinolaryngol. 2014;78:577–82.\nWalls A, Pierce M, Krishnan N, Steehler M, Harley EH. Pediatric head and neck complications of Streptococcus pneumoniae before and after PCV7 vaccination. Otolaryngol Head Neck Surg. 2015;152:336–41.\nKjærulff AMG, Thomsen MK, Ovesen T, Klug TE. Clinical and biochemical characteristics of patients with Fusobacterium necrophorum-positive acute tonsillitis. Eur Arch Otorhinolaryngol. 2015;272:1457–63.\nCheng J, Kleinberger AJ, Sikora A. Fusobacterium necrophorum in a pediatric retropharyngeal abscess: a case report and review of the literature. Ear Nose Throat J. 2014;93:E22–4.\nNovis SJ, Pritchett CV, Thorne MC, Sun GH. Pediatric deep space neck infections in U.S. children, 2000-2009. Int J Pediatr Otorhinolaryngol. 2014;78:832–6. Describes significant trends in the incidence and management of deep neck abscesses.\nQureshi H et al. Trends in the management of pediatric peritonsillar abscess infections in the U.S., 2000-2009. Int J Pediatr Otorhinolaryngol. 2015;79:527–31. Describes the changes in management of peritonsillar abscesses towards increased incision and drainage and decreased tonsillectomy.\nSingh S, Vignesh P, Burgner D. The epidemiology of Kawasaki disease: a global update. Arch Dis Child. 2015;1–5. doi:10.1136\u002Farchdischild-2014-307536.\nSundel RP. Kawasaki disease. Rheum Dis Clin N Am. 2015;41:63–73. viii.\nBayers S, Shulman ST, Paller AS. Kawasaki disease: part I. Diagnosis, clinical features, and pathogenesis. J Am Acad Dermatol. 2013;69.\nYoskovitch A, Tewfik TL, Duffy CM, Moroz B. Head and neck manifestations of Kawasaki disease. Int J Pediatr Otorhinolaryngol. 2000;52:123–9.\nNomura O et al. Comparison of patients with Kawasaki disease with retropharyngeal edema and patients with retropharyngeal abscess. Eur J Pediatr. 2014;173:381–6.\nTona R et al. Risk factors for retropharyngeal cellulitis in Kawasaki disease. Auris Nasus Larynx. 2014;41:455–8.\nPuhakka L et al. Retropharyngeal involvement in Kawasaki disease--a report of four patients with retropharyngeal edema verified by magnetic resonance imaging. Int J Pediatr Otorhinolaryngol. 2014;78:1774–8.",{"VOID":634},"10.1007\u002Fs40746-016-0063-7","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs40746-016-0063-7",[637,652],{"id":638,"sortIndex":19,"researcher":18,"roles":639,"affiliations":640,"properties":649,"displayName":651,"givenName":18,"familyName":18},"4955afb4-9e52-4bcf-aa2c-55eb30e4f0b0",[117],[641],{"id":642,"sortIndex":19,"affiliation":643,"properties":18},"d2bf0cac-1823-4191-aa4c-facad6706794",{"id":642,"createTime":18,"updateTime":18,"relativeEntities":644,"slug":18,"properties":645,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":648,"statistic":18},[],{"title":646},{"VI":647},"Clinical Otolaryngology, Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine of USC, Los Angeles, USA",[],{"title":650},{"VI":651},"Christian J. Hochstim",{"id":653,"sortIndex":65,"researcher":18,"roles":654,"affiliations":655,"properties":664,"displayName":666,"givenName":18,"familyName":18},"eb256bef-e42f-4d53-8ee8-7788c699b8cb",[117],[656],{"id":657,"sortIndex":19,"affiliation":658,"properties":18},"183712d5-4bf8-43c1-af24-55ea5549246e",{"id":657,"createTime":18,"updateTime":18,"relativeEntities":659,"slug":18,"properties":660,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":663,"statistic":18},[],{"title":661},{"VI":662},"Otolaryngology\u002FHead & Neck Surgery, Department of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Stanford, USA",[],{"title":665},{"VI":666},"Anna H. Messner",{"url":635,"publisher":668,"properties":697},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":669,"slug":10,"properties":670,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":673,"manageAffiliations":678,"indexDatabases":684,"url":54,"thumbnailPath":18,"statistic":692,"gsStatistic":18,"type":86,"analyzePriority":18},[],{"issn":671,"title":672},{"VOID":13},{"EN":15},[674],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":675,"label":676,"description":677,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[679],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":680,"slug":18,"properties":681,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":683,"statistic":18},[],{"title":682},{"EN":33},[35],[685],{"id":38,"indexDatabase":686,"url":49,"indexYears":50,"academicFieldIds":691,"indexDatabaseRanking":53},{"id":40,"createTime":18,"updateTime":18,"relativeEntities":687,"label":688,"description":689,"key":46,"publicationTags":690,"standard":18},[],{"EN":43,"VI":43},{"EN":43,"VI":45},[48],[52],{"impactFactor":19,"impactFactorByYear":693,"i10Index":62,"i10IndexLast5Year":62,"totalPublication":63,"totalPublicationByYear":694,"totalCitation":74,"totalCitationByYear":695,"totalCitationPerPublication":80,"totalCitationPerPublicationByYear":696,"hindexLast5Year":76,"hindex":76},{"2017":57,"2020":58,"2021":59,"2022":60,"2023":61},{"2014":65,"2015":66,"2016":67,"2017":68,"2018":69,"2019":70,"2020":71,"2021":72,"2022":73,"2023":72},{"2015":76,"2016":77,"2018":65,"2019":78,"2020":79,"2021":76},{"2015":82,"2016":83,"2018":57,"2019":84,"2020":85,"2021":80},{"pages":698,"volume":700},{"VOID":699},"216-223",{"VOID":701},"2","2016-07-21",2016,[53],{"id":706,"createTime":707,"updateTime":708,"relativeEntities":709,"slug":710,"properties":711,"entityType":108,"verifyStatus":109,"verifyTime":708,"verifyNote":111,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":720,"fullTextUrl":18,"authors":721,"publicationType":139,"publisherRelationship":752,"citationCount":18,"citationInfo":18,"publishDate":786,"publishYear":268,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":787,"openAccess":18,"references":18,"isForceReanalyzing":181},"5b7c29b1-0616-4ebc-b413-80555a978de2","2024-01-08T21:43:57.211+00:00","2025-02-24T23:02:14.548+00:00",[],"Stridor-in-the-Primary-Care-Setting",{"abstract":712,"title":714,"references":716,"doi":718},{"EN":713},"This paper will review common etiologies of stridor for primary care specialists with an emphasis on recent literature. New international consensus recommendations for laryngomalacia provide management algorithms per symptom severity with acid suppression therapy being considered prior to surgery for moderate laryngomalacia. CT imaging has been proposed over diagnostic bronchoscopy for patients with suspected foreign body aspiration. Endoscopic balloon dilation is successful in 50–100% of subglottic stenosis cases dependent on the severity. Vocal fold immobility resolution occurs in up to 40% of idiopathic cases versus only a quarter of neurologic and cardiac etiologies. Speech therapy is first-line treatment of vocal cord dysfunction. A thorough history and physical with special consideration of presenting age and stridor characteristics is imperative for accurate diagnosis. Flexible laryngoscopy, direct laryngoscopy and bronchoscopy, and\u002For imaging are utilized in many cases for diagnosis and\u002For management.",{"EN":715},"Stridor in the Primary Care Setting",{"VOID":717},"Ida JB, Thompson DM. Pediatric stridor. Otolaryngol Clin N Am. 2014;47(5):795–819. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.otc.2014.06.005.\nKoltai PJ, Lin AC, Stridor HJ. Presentation and evaluation. In: Bluestone CD, Simons JP, Healy GB, editors. Bluestone and Stool’s pediatric otolaryngology. 5th ed. Shelton: People’s Medical Publishing House; 2014. p. 1473–84.\nPasha R, Golub JS. Otolaryngology: head and neck surgery: clinical reference guide. 4th ed. San Diego: Plural Publishing; 2014.\nDeacon JWF, Widger J, Soma MA. Paediatric tracheomalacia - a review of clinical features and comparison of diagnostic imaging techniques. Int J Pediatr Otorhinolaryngol. 2017;98:75–81. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijporl.2017.04.027.\nEvans WN, Acherman RJ, Ciccolo ML, Carrillo SA, Mayman GA, Luna CF, et al. Vascular ring diagnosis and management: notable trends over 25 years. World J Pediatr Congenit Heart Surg. 2016;7(6):717–20.\nAntón-Pacheco JL, Morante R. Operative or non-operative treatment of congenital tracheal stenosis: is there something new? J Thorac Dis. 2017;9(12):4878–80. https:\u002F\u002Fdoi.org\u002F10.21037\u002Fjtd.2017.11.75.\n•• Carter J, Rahbar R, Brigger M, Chan K, Cheng A, Daniel SJ, et al. International Pediatric ORL Group (IPOG) laryngomalacia consensus recommendations. Int J Pediatr Otorhinolaryngol. 2016;86:256–61. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijporl.2016.04.007 Comprehensive up-to-date international consensus recommendations for laryngomalacia including evaluation and treatment, initial and comprehensive care algorithms, management of feeding difficulties, post-surgical and persistent laryngomalacia algorithms, and acid suppression recommendations.\nSchroeder JW Jr, Bhandarkar ND, Holinger LD. Synchronous airway lesions and outcomes in infants with severe laryngomalacia requiring supraglottoplasty. Arch Otolaryngol Head Neck Surg. 2009;135(7):647–51. https:\u002F\u002Fdoi.org\u002F10.1001\u002Farchoto.2009.73.\nDurvasula VS, Lawson BR, Bower CM, Richter GT. Supraglottoplasty in premature infants with laryngomalacia: does gestation age at birth influence outcomes? Otolaryngol Head Neck Surg. 2014;150(2):292–9. https:\u002F\u002Fdoi.org\u002F10.1177\u002F0194599813514370.\n• Jabbour J, Martin T, Beste D, Robey T. Pediatric vocal fold immobility: natural history and the need for long-term follow-up. JAMA Otolaryngol Head Neck Surg. 2014;140(5):428–33 A well designed retrospective review of pediatric vocal fold immobility including etiology, incidence and long-term outcomes. A good resource to read prior to counseling patients and their families.\nDewan K, Cephus C, Owczarzak V, Ocampo E. Incidence and implication of vocal fold paresis following neonatal cardiac surgery. Laryngoscope. 2012;122(12):2781–5. https:\u002F\u002Fdoi.org\u002F10.1002\u002Flary.23575.\nEngeseth MS, Olsen NR, Maeland S, Halvorsen T, Goode A, Røksund OD. Left vocal cord paralysis after patent ductus arteriosus ligation: a systematic review. Paediatr Respir Rev. 2018;27:74–85. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.prrv.2017.11.001.\nDaya H, Hosni A, Bejar-Solar I, Evans JN, Bailey CM. Pediatric vocal fold paralysis: a long-term retrospective study. Arch Otolaryngol Head Neck Surg. 2000;126(1):21–5.\nNichols BG, Jabbour J, Hehir DA, Ghanayem NS, Beste D, Martin T, et al. Recovery of vocal fold immobility following isolated patent ductus arteriosus ligation. Int J Pediatr Otorhinolaryngol. 2014;78(8):1316–9. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijporl.2014.05.019.\nZalzal GH, Cotton RT. Glottic and Subglottic Stenosis. In: Flint PW, Haughey BH, Lund V, Niparko JK, Robbins KT, Thomas JR, Lesperance MM, editors. Cummings otolaryngology. 6th ed. Philadelphia: Elsevier; 2015. p. 3158–70.e3.\nMyer CM 3rd, O’Connor DM, Cotton RT. Proposed grading system for subglottic stenosis based on endotracheal tube sizes. Ann Otol Rhinol Laryngol. 1994;103(4 Pt 1):319–23.\nJefferson ND, Cohen AP, Rutter MJ. Subglottic stenosis. Semin Pediatr Surg. 2016;25(3):138–43. https:\u002F\u002Fdoi.org\u002F10.1053\u002Fj.sempedsurg.2016.02.006.\nManica D, Schweiger C, Maróstica PJ, Kuhl G, Carvalho PR. Association between length of intubation and subglottic stenosis in children. Laryngoscope. 2013;123(4):1049–54. https:\u002F\u002Fdoi.org\u002F10.1002\u002Flary.23771.\nLang M, Brietzke SE. A systematic review and meta-analysis of endoscopic balloon dilation of pediatric subglottic stenosis. Otolaryngol Head Neck Surg. 2014;150(2):174–9. https:\u002F\u002Fdoi.org\u002F10.1177\u002F0194599813510867.\nChueng K, Chadha NK. Primary dilatation as a treatment for pediatric laryngotracheal stenosis: a systematic review. Int J Pediatr Otorhinolaryngol. 2013;77(5):623–8. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijporl.2013.02.003.\nChen C, Ni WH, Tian TL, Xu ZM. The outcomes of endoscopic management in young children with subglottic stenosis. Int J Pediatr Otorhinolaryngol. 2017;99:141–5. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijporl.2017.06.012.\nMaresh A, Preciado DA, O’Connell AP, Zalzal GH. A comparative analysis of open surgery vs endoscopic balloon dilation for pediatric subglottic stenosis. JAMA Otolaryngol Head Neck Surg. 2014;140(10):901–5. https:\u002F\u002Fdoi.org\u002F10.1001\u002Fjamaoto.2014.1742.\nLicari A, Manca E, Rispoli GA, Mannarino S, Pelizzo G, Marseglia GL. Congenital vascular rings: a clinical challenge for the pediatrician. Pediatr Pulmonol. 2015;50(5):511–24. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fppul.23152.\nSchroeder JW, Holinger LD. Congenital anomalies of the larynx, trachea, and bronchi. In: Kliegman RM, Stanton BF, St Geme JW, Schor NF, editors. Nelson textbook of pediatrics. 20th ed. Philadelphia: Elsevier; 2016. p. 2036–39.e3.\nBacker CL, Mongé MC, Popescu AR, Eltayeb OM, Rastatter JC, Rigsby CK. Vascular rings. Semin Pediatr Surg. 2016;25(3):165–75. https:\u002F\u002Fdoi.org\u002F10.1053\u002Fj.sempedsurg.2016.02.009.\nJanahi IA, Khan S, Chandra P, Al-Marri N, Saadoon A, Al-Naimi L, et al. A new clinical algorithm scoring for management of suspected foreign body aspiration in children. BMC Pulm Med. 2017;17(1):61. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12890-017-0406-6.\nRoberts CA, Carr MM. Morbidity and mortality in children undergoing bronchoscopy for foreign body removal. Laryngoscope. 2017;128:1226–9. https:\u002F\u002Fdoi.org\u002F10.1002\u002Flary.26817.\nJohnson K, Linnaus M, Notrica D. Airway foreign bodies in pediatric patients: anatomic location of foreign body affects complications and outcomes. Pediatr Surg Int. 2017;33(1):59–64. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00383-016-3988-9.\nSink JR, Kitsko DJ, Georg MW, Winger DG, Simons JP. Predictors of foreign body aspiration in children. Otolaryngol Head Neck Surg. 2016;155(3):501–7. https:\u002F\u002Fdoi.org\u002F10.1177\u002F0194599816644410.\nSheehan CC, Lopez J, Elmaraghy CA. Low rate of positive bronchoscopy for suspected foreign body aspiration in infants. Int J Pediatr Otorhinolaryngol. 2018;104:72–5. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijporl.2017.10.030.\nMartin A, van der Meer G, Blair D, Mahadevan M, Neeff M, Barber C, et al. Long-standing inhaled foreign bodies in children: characteristics and outcome. Int J Pediatr Otorhinolaryngol. 2016;90:49–53. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijporl.2016.08.018.\nPetrocheilou A, Tanou K, Kalampouka E, Malakasioti G, Giannios C, Kaditis AG. Viral croup: diagnosis and a treatment algorithm. Pediatr Pulmonol. 2014;49(5):421–9. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fppul.22993.\nYellon RF, Chi DH. Otolaryngology. In: Ziteli BJ, McIntire SC, Nowalk AJ, editors. Zitelli and Davis’ atlas of pediatric physical diagnosis. 7th ed. Philadelphia: Elsevier; 2018. p. 868–915.\nHiebert JC, Zhao YD, Willis EB. Bronchoscopy findings in recurrent croup: a systematic review and meta-analysis. Int J Pediatr Otorhinolaryngol. 2016;90:86–90. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijporl.2016.09.003.\nSmith B, Milstein C, Rolfes B, Anne S. Paradoxical vocal fold motion (PVFM) in pediatric otolaryngology. Am J Otolaryngol. 2017;38(2):230–2. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.amjoto.2017.01.027.\nFretzayas A, Moustaki M, Loukou I, Douros K. Differentiating vocal cord dysfunction from asthma. J Asthma Allergy. 2017;10:277–83. Published online. https:\u002F\u002Fdoi.org\u002F10.2147\u002FJAA.S146007.\nPowell DM, Karanfilov BI, Beechler KB, Treole K, Trudeau MD, Forrest LA. Paradoxical vocal cord dysfunction in juveniles. Arch Otolaryngol Head Neck Surg. 2000;126(1):29–34.\nHilland M, Røksund OD, Sandvik L, Haaland Ø, Aarstad HJ, Halvorsen T, et al. Congenital laryngomalacia is related to exercise-induced laryngeal obstruction in adolescence. Arch Dis Child. 2016;101(5):443–8. https:\u002F\u002Fdoi.org\u002F10.1136\u002Farchdischild-2015-308450.\nJohnston KL, Bradford H, Hodges H, Moore CM, Nauman E, Olin JT. The Olin EILOBI breathing techniques: description and initial case series of novel respiratory retraining strategies for athletes with exercise-induced laryngeal obstruction. J Voice. 2017. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jvoice.2017.08.020.",{"VOID":719},"10.1007\u002Fs40746-018-0144-x","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs40746-018-0144-x",[722,737],{"id":723,"sortIndex":19,"researcher":18,"roles":724,"affiliations":725,"properties":734,"displayName":736,"givenName":18,"familyName":18},"89775232-0a50-4904-8b7b-d7d97aadde4d",[117],[726],{"id":727,"sortIndex":19,"affiliation":728,"properties":18},"5ee377cb-9950-4f4d-836e-83668a211315",{"id":727,"createTime":18,"updateTime":18,"relativeEntities":729,"slug":18,"properties":730,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":733,"statistic":18},[],{"title":731},{"VI":732},"Department of Pediatric Otolaryngology, Cook Children’s Medical Center, Fort Worth, USA",[],{"title":735},{"VI":736},"Allison G. Chisholm",{"id":738,"sortIndex":65,"researcher":18,"roles":739,"affiliations":740,"properties":749,"displayName":751,"givenName":18,"familyName":18},"a1b334b3-98a6-47cb-b85d-3d31d14e645c",[117],[741],{"id":742,"sortIndex":19,"affiliation":743,"properties":18},"9e0aa289-0a94-43e3-a0af-63c38f94e6ac",{"id":742,"createTime":18,"updateTime":18,"relativeEntities":744,"slug":18,"properties":745,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":748,"statistic":18},[],{"title":746},{"VI":747},"Department of Otolaryngology- Head and Neck Surgery, University of Texas - Southwestern, Dallas, USA",[],{"title":750},{"VI":751},"Romaine F. Johnson",{"url":720,"publisher":753,"properties":782},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":754,"slug":10,"properties":755,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":758,"manageAffiliations":763,"indexDatabases":769,"url":54,"thumbnailPath":18,"statistic":777,"gsStatistic":18,"type":86,"analyzePriority":18},[],{"issn":756,"title":757},{"VOID":13},{"EN":15},[759],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":760,"label":761,"description":762,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[764],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":765,"slug":18,"properties":766,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":768,"statistic":18},[],{"title":767},{"EN":33},[35],[770],{"id":38,"indexDatabase":771,"url":49,"indexYears":50,"academicFieldIds":776,"indexDatabaseRanking":53},{"id":40,"createTime":18,"updateTime":18,"relativeEntities":772,"label":773,"description":774,"key":46,"publicationTags":775,"standard":18},[],{"EN":43,"VI":43},{"EN":43,"VI":45},[48],[52],{"impactFactor":19,"impactFactorByYear":778,"i10Index":62,"i10IndexLast5Year":62,"totalPublication":63,"totalPublicationByYear":779,"totalCitation":74,"totalCitationByYear":780,"totalCitationPerPublication":80,"totalCitationPerPublicationByYear":781,"hindexLast5Year":76,"hindex":76},{"2017":57,"2020":58,"2021":59,"2022":60,"2023":61},{"2014":65,"2015":66,"2016":67,"2017":68,"2018":69,"2019":70,"2020":71,"2021":72,"2022":73,"2023":72},{"2015":76,"2016":77,"2018":65,"2019":78,"2020":79,"2021":76},{"2015":82,"2016":83,"2018":57,"2019":84,"2020":85,"2021":80},{"pages":783,"volume":785},{"VOID":784},"456-466",{"VOID":266},"2018-10-25",[],{"id":789,"createTime":790,"updateTime":791,"relativeEntities":792,"slug":793,"properties":794,"entityType":108,"verifyStatus":109,"verifyTime":791,"verifyNote":111,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":803,"fullTextUrl":18,"authors":804,"publicationType":139,"publisherRelationship":844,"citationCount":18,"citationInfo":18,"publishDate":879,"publishYear":880,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":881,"openAccess":18,"references":18,"isForceReanalyzing":181},"d4f7e363-5f3f-4fe2-b3ce-cfde34891b7b","2024-02-22T02:31:07.337+00:00","2025-02-24T10:46:38.730+00:00",[],"Methicillin-Resistant-Staphylococcus-aureus-MRSA-Review-of-Current-Treatment-Options-in-Pediatrics",{"abstract":795,"title":797,"references":799,"doi":801},{"EN":796},"Methicillin-resistant Staphylococcus aureus (MRSA) infections have significant morbidity and mortality in pediatrics. Although, MRSA frequently causes skin and soft tissue infections (SSTI), invasive infections due to MRSA have become increasingly common. This review aims to provide clinicians with the current treatment options available for invasive and non-invasive MRSA infections in pediatrics. MRSA resistance is increasing and antibiotics, such as clindamycin and TMP-SMX, may not be as effective. Ceftaroline is a newer agent that has been approved in the USA and Canada for the management of acute bacterial SSTI and community acquired pneumonias caused by MRSA. Vancomycin remains the mainstay of therapy for most invasive MRSA infections. However, the choice of antibiotic used in the clinical setting can depend on many factors: resistance patterns, site of infection, age and geographical location of the patient, side effects and availability of antibiotics. In pediatrics, future clinical studies are required to determine the efficacy and safety of novel antibiotics such as ceftaroline.",{"EN":798},"Methicillin-Resistant Staphylococcus aureus (MRSA): Review of Current Treatment Options in Pediatrics",{"VOID":800},"Vanderkoo OG, Gregson DB, Kellner JD, Laupland KB. Staphylococcus aureus bloodstream infections in children: a population-based assessment. Paediatr Child Health. 2011;16(5):276–80.\nSuryati B, Watson M. Staphylococcus aureus bacteraemia in children: a 5-year retrospective review. J Paediatr Child Health. 2002;38(3):290–4.\n•• McMullan BJ, Campbell AJ, Blyth CC, McNeil JC, Montgomery CP, Tong SYC, et al. Clinical management of Staphylococcus aureus bacteremia in neonates, children, and adolescents. Pediatrics. 2020;146(3):e20200134. Findings showed the different presentations and risk factors for MRSA bacteremia. It was discussed that in pediatrics, a large cohort of patients with SA bacteremia are healthy children with no medical problems which is different from adults.\n•• Kaplan SL. Methicillin-resistant Staphylococcus aureus infections in children: epidemiology and clinical spectrum [Internet]. 2021. Available from: https:\u002F\u002Fwww.uptodate.com\u002Fcontents\u002Fmethicillin-resistant-staphylococcus-aureus-infections-in-children-epidemiology-and-clinical-spectrum\u002Fprint?topicRef=6025&so…1\u002F26OfficialreprintfromUpToDatewww.uptodate.com. Accessed 21 Nov 2021. This paper discussed the updated geographical differences along with recent incidence and prevalence of MRSA. Furthermore, updated definitions for hospital and community onset were established. Key points regarding pathogenesis and clinical spectrum of MRSA were reported. Since rates of resistance are increasing and MRSA is no longer only a nosocomial infection, it is Important for clinicians in the community to be aware of the alternative risk factors and high risk populations.\nDavid MZ, Daum RS. Community-associated methicillin-resistant Staphylococcus aureus : epidemiology and clinical consequences of an emerging epidemic. Clin Microbiol Rev. 2010;23(3):616–87.\nSiddiqui AH, Koirala J. Methicillin resistant Staphylococcus aureus. 2022. Available from: https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F29489200\u002F.\nKreiswirth B, Kornblum J, Arbeit RD, Eisner W, Maslow JN, McGeer A, et al. (1993) Evidence for a clonal origin of methicillin resistance in Staphylococcus aureus. Science. 1979;259(5092):227–30.\nZeng D, Debabov D, Hartsell TL, Cano RJ, Adams S, Schuyler JA, et al. Approved glycopeptide antibacterial drugs: mechanism of action and resistance. Cold Spring Harb Perspect Med. 2016;6(12):a026989.\nLiu C, Bayer A, Cosgrove SE, Daum RS, Fridkin SK, Gorwitz RJ, et al. Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis. 2011;52(3). Available from: https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F21217178\u002F.\nDrew RH, Sakoulas G. Vancomycin: parenteral dosing, monitoring, and adverse effects in adults [Internet]. 2022. Available from: https:\u002F\u002Fwww.uptodate.com\u002Fcontents\u002Fvancomycin-parenteral-dosing-monitoring-and-adverse-effects-in-adults\u002Fprint?search=vancomycindosing&source=search_result…1\u002F37OfficialreprintfromUpToDatewww.uptodate.com. Accessed 27 Jan 2022.\nRybak MJ, Le J, Lodise TP, Levine DP, Bradley JS, Liu C, et al. Therapeutic monitoring of vancomycin for serious methicillin-resistant Staphylococcus aureus infections: a revised consensus guideline and review by the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists. Am J Health Syst Pharm. 2020;77(11):835–64.\nFinch NA, Zasowski EJ, Murray KP, Mynatt RP, Zhao JJ, Yost R, et al. A quasi-experiment to study the impact of vancomycin area under the concentration-time curve-guided dosing on vancomycin-associated nephrotoxicity.Antimicrob Agents Chemother. 2017;61(12). Available from: https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F28923869\u002F.\nNeely MN, Kato L, Youn G, Kraler L, Bayard D, van Guilder M, et al. Prospective trial on the use of trough concentration versus area under the curve to determine therapeutic vancomycin dosing. Antimicrob Agents Chemother. 2018;62(2). 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Linezolid and tedizolid (oxazolidinones): an overview [Internet]. 2022. Available from: https:\u002F\u002Fwww.uptodate.com\u002Fcontents\u002Flinezolid-and-tedizolid-oxazolidinones-an-overview\u002Fprint?search=linezolid&source=search_result&selectedTitle=2~148&usage…1\u002F26OfficialreprintfromUpToDatewww.uptodate.com. Accessed 10 Jan 2022.\nTsona A, Metallidis S, Foroglou N, Selviaridis P, Chrysanthidis T, Lazaraki G, et al. Linezolid penetration into cerebrospinal fluid and brain tissue. J Chemother. 2010;22(1):17–9.\nSipahi OR, Bardak-Ozcem S, Turhan T, Arda B, Ruksen M, Pullukcu H, et al. Vancomycin versus linezolid in the treatment of methicillin-resistant Staphylococcus aureus meningitis. Surg Infect (Larchmt). 2013;14(4):357–62.\nDryden MS. Linezolid pharmacokinetics and pharmacodynamics in clinical treatment. J Antimicrob Chemother. 2011;66(Supplement 4):iv7-15.\nHirano M, Palenzuela L, Hahn NM, Nelson RP, Arno JN, Schobert C, et al. Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis? Clin Infect Dis. 2005;40(12):e113–6.\nMoellering RC. Linezolid: the first oxazolidinone antimicrobial. Ann Intern Med. 2003;138(2):135.\nKim A, Suecof LA, Sutherland CA, Gao L, Kuti JL, Nicolau DP. In vivo microdialysis study of the penetration of daptomycin into soft tissues in diabetic versus healthy volunteers. Antimicrob Agents Chemother. 2008;52(11):3941–6.\nSeaton RA, Malizos KN, Viale P, Gargalianos-Kakolyris P, Santantonio T, Petrelli E, et al. Daptomycin use in patients with osteomyelitis: a preliminary report from the EU-CORESM database. J Antimicrob Chemother. 2013;68(7):1642–9.\nLamp KC, Friedrich LV, Mendez-Vigo L, Russo R. Clinical experience with daptomycin for the treatment of patients with osteomyelitis. Am J Med. 2007;120(10):S13-20.\nMoenster RP, Linneman TW, Finnegan PM, McDonald JR. Daptomycin compared to vancomycin for the treatment of osteomyelitis: a single-center, retrospective cohort study. Clin Ther. 2012;34(7):1521–7.\nMurray KP, Zhao JJ, Davis SL, Kullar R, Kaye KS, Lephart P, et al. Early use of daptomycin versus vancomycin for methicillin-resistant Staphylococcus aureus bacteremia with vancomycin minimum inhibitory concentration >1 mg\u002FL: a matched cohort study. Clin Infect Dis. 2013;56(11):1562–9.\nAbdel-Rahman SM, Chandorkar G, Akins RL, Bradley JS, Jacobs RF, Donovan J, et al. Single-dose pharmacokinetics and tolerability of daptomycin 8 to 10 mg\u002Fkg in children aged 2 to 6 years with suspected or proved Gram-positive infections. Pediatr Infect Dis J. 2011;30(8):712–4.\nhttps:\u002F\u002Fclinicalinfo.hiv.gov\u002Fen\u002Fdrugs\u002Fsulfamethoxazole-trimethoprim\u002Fpatient. Accessed 20 Jan 2022.\nPaul M, Bishara J, Yahav D, Goldberg E, Neuberger A, Ghanem-Zoubi N, et al. Trimethoprim-sulfamethoxazole versus vancomycin for severe infections caused by meticillin resistant Staphylococcus aureus: randomised controlled trial. BMJ. 2015;350(may14 24):h2219–h2219.\nThyagarajan B, Deshpande SS. Cotrimoxazole and neonatal kernicterus: a review. Drug Chem Toxicol. 2014;37(2):121–9.\nKhamash DF, Voskertchian A, Tamma PD, Akinboyo IC, Carroll KC, Milstone AM. Increasing clindamycin and trimethoprim-sulfamethoxazole resistance in pediatric Staphylococcus aureus infections. J Pediatric Infect Dis Soc. 2019;8(4):351–3.\nCosgrove SE, Fowler VG Jr. Management of methicillin-resistant Staphylococcus aureus bacteremia. Clin Infect Dis. 2008;46(S5):S386–93.\nBouazza N, Pestre V, Jullien V, Curis E, Urien S, Salmon D, et al. Population pharmacokinetics of clindamycin orally and intravenously administered in patients with osteomyelitis. Br J Clin Pharmacol. 2012;74(6):971–7.\nNau R, Sörgel F, Eiffert H. Penetration of drugs through the blood-cerebrospinal fluid\u002Fblood-brain barrier for treatment of central nervous system infections. Clin Microbiol Rev. 2010;23(4):858–83.\nKaushik A, Kest H. Pediatric methicillin-resistant staphylococcus aureus osteoarticular infections. Vol. 6, Microorganisms.MDPI AG; 2018. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fmicroorganisms6020040.\nGurwith MJ, Rabin HR, Love K. Diarrhea associated with clindamycin and ampicillin therapy: preliminary results of a cooperative study. J Infect Dis. 1977;135(Supplement):S104–10.\nCorey A, So TY. Current clinical trials on the use of ceftaroline in the pediatric population. Vol. 37, Clinical drug investigation. Springer International Publishing; 2017. p. 625–34. Available from: https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F28382572\u002F.\nChen CW, Chang SP, Huang HT, Tang HJ, Lai CC. The efficacy and safety of ceftaroline in the treatment of acute bacterial infection in pediatric patients – a systemic review and meta-analysis of randomized controlled trials. Infect Drug Resist. 2019;12:1303–10.\n•• Bradley JS, Stone GG, Chan PLS, Raber SR, Riccobene T, Mas Casullo V, et al. Phase 2 study of the safety, pharmacokinetics and efficacy of ceftaroline fosamil in neonates and very young infants with late-onset sepsis. Pediatr Infect Dis J. 2020;39(5):411–8. Findings from this study showed that ceftaroline can be used in a wide range of ages (neonates Older children) with minimal side effects for ill patients with sepsis. In addition, dosing was provided which is helpful for clinicians, as resistance to older therapies develops.\nYim J, Molloy LM, Newland JG. Use of ceftaroline fosamil in children: review of current knowledge and its application. Infect Dis Ther. 2017;6(1):57–67.\nCies JJ, Moore WS, Enache A, Chopra A. Ceftaroline cerebrospinal fluid penetration in the treatment of a ventriculopleural shunt infection: a case report. J Pediatr Pharmacol Ther. 2020;25(4):336–9.\nKato H, Hagihara M, Asai N, Shibata Y, Koizumi Y, Yamagishi Y, et al. Meta-analysis of vancomycin versus linezolid in pneumonia with proven methicillin-resistant Staphylococcus aureus. J Glob Antimicrob Resist. 2021;24:98–105.\nHuang C, Chen I, Lin L. Comparing the outcomes of ceftaroline plus vancomycin or daptomycin combination therapy versus vancomycin or daptomycin monotherapy in adults with methicillin-resistant Staphylococcus aureus bacteremia-a meta-analysis. Antibiotics (Basel, Switzerland). 2022;11(8):1104.\nWilcox MH, Tack KJ, Bouza E, Herr DL, Ruf BR, Ijzerman MM, et al. Complicated skin and skin-structure infections and catheter-related bloodstream infections: noninferiority of linezolid in a phase 3 study. Clin Infect Dis. 2009;48(2):203–12.",{"VOID":802},"10.1007\u002Fs40746-023-00265-2","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs40746-023-00265-2",[805,820],{"id":806,"sortIndex":19,"researcher":18,"roles":807,"affiliations":808,"properties":817,"displayName":819,"givenName":18,"familyName":18},"9c731312-d612-4151-8974-24943e567360",[117],[809],{"id":810,"sortIndex":19,"affiliation":811,"properties":18},"c82790e9-d3aa-4d06-9089-d3298b91636e",{"id":810,"createTime":18,"updateTime":18,"relativeEntities":812,"slug":18,"properties":813,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":816,"statistic":18},[],{"title":814},{"VI":815},"Division of Pediatric Infectious Diseases, JPCH Children’s Hospital, Saskatoon, Canada",[],{"title":818},{"VI":819},"Rupeena Purewal",{"id":821,"sortIndex":65,"researcher":18,"roles":822,"affiliations":823,"properties":841,"displayName":843,"givenName":18,"familyName":18},"f4b49be5-1194-45e3-85f3-16dcb1bff5fe",[117],[824,832],{"id":825,"sortIndex":19,"affiliation":826,"properties":18},"99a6c5e5-3eca-4cba-be39-54bf5ba39469",{"id":825,"createTime":18,"updateTime":18,"relativeEntities":827,"slug":18,"properties":828,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":831,"statistic":18},[],{"title":829},{"VI":830},"Division of Pediatric Infectious Diseases, BC Children’s Hospital, Vancouver, Canada",[],{"id":833,"sortIndex":65,"affiliation":834,"properties":840},"39e372bf-3ec6-4f79-8faf-337121f3815e",{"id":833,"createTime":18,"updateTime":18,"relativeEntities":835,"slug":18,"properties":836,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":839,"statistic":18},[],{"title":837},{"VI":838},"Division of Pediatric Infectious Disease, Children’s Hospital, London Health Sciences Centre, London, Canada",[],{},{"title":842},{"VI":843},"Alison Lopez",{"url":803,"publisher":845,"properties":874},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":846,"slug":10,"properties":847,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":850,"manageAffiliations":855,"indexDatabases":861,"url":54,"thumbnailPath":18,"statistic":869,"gsStatistic":18,"type":86,"analyzePriority":18},[],{"issn":848,"title":849},{"VOID":13},{"EN":15},[851],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":852,"label":853,"description":854,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[856],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":857,"slug":18,"properties":858,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":860,"statistic":18},[],{"title":859},{"EN":33},[35],[862],{"id":38,"indexDatabase":863,"url":49,"indexYears":50,"academicFieldIds":868,"indexDatabaseRanking":53},{"id":40,"createTime":18,"updateTime":18,"relativeEntities":864,"label":865,"description":866,"key":46,"publicationTags":867,"standard":18},[],{"EN":43,"VI":43},{"EN":43,"VI":45},[48],[52],{"impactFactor":19,"impactFactorByYear":870,"i10Index":62,"i10IndexLast5Year":62,"totalPublication":63,"totalPublicationByYear":871,"totalCitation":74,"totalCitationByYear":872,"totalCitationPerPublication":80,"totalCitationPerPublicationByYear":873,"hindexLast5Year":76,"hindex":76},{"2017":57,"2020":58,"2021":59,"2022":60,"2023":61},{"2014":65,"2015":66,"2016":67,"2017":68,"2018":69,"2019":70,"2020":71,"2021":72,"2022":73,"2023":72},{"2015":76,"2016":77,"2018":65,"2019":78,"2020":79,"2021":76},{"2015":82,"2016":83,"2018":57,"2019":84,"2020":85,"2021":80},{"pages":875,"volume":877},{"VOID":876},"23-35",{"VOID":878},"9","2023-04-13",2023,[53],{"id":883,"createTime":884,"updateTime":885,"relativeEntities":886,"slug":887,"properties":888,"entityType":108,"verifyStatus":109,"verifyTime":885,"verifyNote":111,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":897,"fullTextUrl":18,"authors":898,"publicationType":139,"publisherRelationship":914,"citationCount":18,"citationInfo":18,"publishDate":948,"publishYear":703,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":949,"openAccess":18,"references":18,"isForceReanalyzing":181},"fbb86d7e-8935-43b8-b366-7425773e2aef","2024-01-04T13:08:40.439+00:00","2025-02-23T21:55:13.041+00:00",[],"Nephrotic-Syndrome-Updates-and-Approaches-to-Treatment",{"abstract":889,"title":891,"references":893,"doi":895},{"EN":890},"Nephrotic syndrome (NS) is among the most common pediatric kidney diseases with a high risk of morbidity and mortality due to infection and thrombosis. Goals of treatment are to reduce proteinuria to normal levels thereby reducing symptoms and risk of complications. Children with NS should initially be treated with prednisone or prednisolone at a dose of 60 mg\u002Fm2\u002Fday daily for 6 weeks followed by 40 mg\u002Fm2\u002Fday given every other day for an additional 6 weeks. While most children are steroid responsive, approximately 20 % of children with NS do not go into remission with steroids and should be treated with a calcineurin inhibitor such as cyclosporine or tacrolimus. Some children with NS who respond to steroids eventually have a frequently relapsing or steroid-dependent course and may have significant side effects from cumulative corticosteroid therapy. For these children, steroid-sparing medications are required. Treatment with mycophenolate mofetil is recommended as first-line therapy for treatment of frequently relapsing or steroid-dependent NS with steroid toxicity due to its favorable side effect profile compared to alternatives. If this is not effective, alternate agents such as cyclophosphamide, calcineurin inhibitors, or rituximab could be considered after careful review of the pros and cons of each medication with the child’s family. Further randomized controlled trials are necessary to determine which agents are most effective and to determine methods to predict medication response in individual children.",{"EN":892},"Nephrotic Syndrome: Updates and Approaches to Treatment",{"VOID":894},"The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the International Study of Kidney Disease in Children. J Pediatr 1981;98:561–64.\nSadowski CE, Lovric S, Ashraf S, et al. A single-gene cause in 29.5% of cases of steroid-resistant nephrotic syndrome. J Am Soc Nephrol. 2015;26:1279–89.\nHinkes B, Wiggins RC, Gbadegesin R, et al. Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nat Genet. 2006;38:1397–405.\nTarshish P, Tobin JN, Bernstein J, Edelmann Jr CM. Prognostic significance of the early course of minimal change nephrotic syndrome: report of the International Study of Kidney Disease in Children. J Am Soc Nephrol. 1997;8:769–76.\nVernier RL, Farquhar MG, Brunson JG, Good RA. Chronic renal disease in children; correlation of clinical findings with morphologic characteristics seen by light and electron microscopy. AMA J Dis Child. 1958;96:306–43.\nD'Agati VD, Fogo AB, Bruijn JA, Jennette JC. Pathologic classification of focal segmental glomerulosclerosis: a working proposal. Am J Kidney Dis. 2004;43:368–82.\nArneil GC, Lam CN. Long-term assessment of steroid therapy in childhood nephrosis. Lancet. 1966;2:819–21.\nHingorani SR, Weiss NS, Watkins SL. Predictors of peritonitis in children with nephrotic syndrome. Pediatr Nephrol. 2002;17:678–82.\nMatsell DG, Wyatt RJ. The role of I and B in peritonitis associated with the nephrotic syndrome of childhood. Pediatr Res. 1993;34:84–8.\nMcLean RH, Forsgren A, Bjorksten B, Kim Y, Quie PG, Michael AF. Decreased serum factor B concentration associated with decreased opsonization of Escherichia coli in the idiopathic nephrotic syndrome. Pediatr Res. 1977;11:910–6.\nAnderson DC, York TL, Rose G, Smith CW. Assessment of serum factor B, serum opsonins, granulocyte chemotaxis, and infection in nephrotic syndrome of children. J Infect Dis. 1979;140:1–11.\nBallow M, Kennedy 3rd TL, Gaudio KM, Siegel NJ, McLean RH. Serum hemolytic factor D values in children with steroid-responsive idiopathic nephrotic syndrome. J Pediatr. 1982;100:192–6.\nKerlin BA, Haworth K, Smoyer WE. Venous thromboembolism in pediatric nephrotic syndrome. Pediatr Nephrol 2013.\nKerlin BA, Ayoob R, Smoyer WE. Epidemiology and pathophysiology of nephrotic syndrome-associated thromboembolic disease. Clin J Am Soc Nephrol. 2012;7:513–20.\nRuth EM, Kemper MJ, Leumann EP, Laube GF, Neuhaus TJ. Children with steroid-sensitive nephrotic syndrome come of age: long-term outcome. J Pediatr. 2005;147:202–7.\nShalhoub RJ. Pathogenesis of lipoid nephrosis: a disorder of T-cell function. Lancet. 1974;2:556–60.\nDavin JC. The glomerular permeability factors in idiopathic nephrotic syndrome. Pediatr Nephrol 2015\nRansom RF, Lam NG, Hallett MA, Atkinson SJ, Smoyer WE. Glucocorticoids protect and enhance recovery of cultured murine podocytes via actin filament stabilization. Kidney Int. 2005;68:2473–83.\nXing CY, Saleem MA, Coward RJ, Ni L, Witherden IR, Mathieson PW. Direct effects of dexamethasone on human podocytes. Kidney Int. 2006;70:1038–45.\nKidney Disease: Improving Global Outcomes (KDIGO) Glomerulonephritis Work Group. KDIGO Clinical Practice Guideline for Glomerulonephritis. Kidney Int, Suppl. 2012;2:139–274. This is a comprehensive overview of evidence based treatment recommendations for children with steroid sensitive and steroid resistant nephrotic syndrome.\nHodson EM, Knight JF, Willis NS, Craig JC. Corticosteroid therapy for nephrotic syndrome in children. Cochrane Database Syst Rev 2005:CD001533.\nSinha A, Saha A, Kumar M, et al. Extending initial prednisolone treatment in a randomized control trial from 3 to 6 months did not significantly influence the course of illness in children with steroid-sensitive nephrotic syndrome. Kidney Int. 2015;87:217–24. This paper describes a randomized, placebo-controlled trial in children with their initial episode of nephrotic syndrome. They found that extending therapy from 3 to 6 months did not influence the course of illness or proportion of children with adverse effects.\nTeeninga N, Kist-van Holthe JE, van Rijswijk N, et al. Extending prednisolone treatment does not reduce relapses in childhood nephrotic syndrome. J Am Soc Nephrol. 2013;24:149–59.\nAlternate-day prednisone is more effective than intermittent prednisone in frequently relapsing nephrotic syndrome. A report of \"Arbeitsgemeinschaft fur Padiatrische Nephrologie. Eur J Pediatr 1981;135:229–237.\nShort versus standard prednisone therapy for initial treatment of idiopathic nephrotic syndrome in children. Arbeitsgemeinschaft fur Padiatrische Nephrologie. Lancet 1988;1:380–383.\nPasini A, Aceto G, Ammenti A, et al. Best practice guidelines for idiopathic nephrotic syndrome: recommendations versus reality. Pediatr Nephrol. 2015;30:91–101.\nMacHardy N, Miles PV, Massengill SF, et al. Management patterns of childhood-onset nephrotic syndrome. Pediatr Nephrol. 2009;24:2193–201.\nSamuel S, Morgan CJ, Bitzan M, et al. Substantial practice variation exists in the management of childhood nephrotic syndrome. Pediatr Nephrol. 2013;28:2289–98.\nGipson DS, Massengill SF, Yao L, et al. Management of childhood onset nephrotic syndrome. Pediatrics. 2009;124:747–57.\nBagga A. Revised guidelines for management of steroid-sensitive nephrotic syndrome. Indian J Nephrol. 2008;18:31–9.\nSrivastava RN, Vasudev AS, Bagga A, Sunderam KR. Long-term, low-dose prednisolone therapy in frequently relapsing nephrotic syndrome. Pediatr Nephrol. 1992;6:247–50.\nLiu D, Ahmet A, Ward L, et al. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. Allergy Asthma Clin Immunol. 2013;9:30.\nProspective, controlled trial of cyclophosphamide therapy in children with nephrotic syndrome. Report of the International study of Kidney Disease in Children. Lancet 1974;2:423–427.\nTarshish P, Tobin JN, Bernstein J, Edelmann Jr CM. Cyclophosphamide does not benefit patients with focal segmental glomerulosclerosis. A report of the International Study of Kidney Disease in Children. Pediatr Nephrol. 1996;10:590–3.\nPlank C, Kalb V, Hinkes B, Hildebrandt F, Gefeller O, Rascher W. Arbeitsgemeinschaft fur Padiatrische N: Cyclosporin A is superior to cyclophosphamide in children with steroid-resistant nephrotic syndrome-a randomized controlled multicentre trial by the Arbeitsgemeinschaft fur Padiatrische Nephrologie. Pediatr Nephrol. 2008;23:1483–93.\nLatta K, von Schnakenburg C, Ehrich JH. A meta-analysis of cytotoxic treatment for frequently relapsing nephrotic syndrome in children. Pediatr Nephrol. 2001;16:271–82.\nBarratt TM, Soothill JF. Controlled trial of cyclophosphamide in steroid-sensitive relapsing nephrotic syndrome of childhood. Lancet. 1970;2:479–82.\nAzib S, Macher MA, Kwon T, et al. Cyclophosphamide in steroid-dependent nephrotic syndrome. Pediatr Nephrol. 2011;26:927–32.\nGajjar R, Miller SD, Meyers KE, Ginsberg JP. Fertility preservation in patients receiving cyclophosphamide therapy for renal disease. Pediatr Nephrol. 2015;30:1099–106.\nFaul C, Donnelly M, Merscher-Gomez S, et al. The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A. Nat Med. 2008;14:931–8.\nChoudhry S, Bagga A, Hari P, Sharma S, Kalaivani M, Dinda A. Efficacy and safety of tacrolimus versus cyclosporine in children with steroid-resistant nephrotic syndrome: a randomized controlled trial. Am J Kidney Dis. 2009;53:760–9.\nGulati A, Sinha A, Gupta A, et al. Treatment with tacrolimus and prednisolone is preferable to intravenous cyclophosphamide as the initial therapy for children with steroid-resistant nephrotic syndrome. Kidney Int. 2012;82:1130–5.\nCattran DC, Appel GB, Hebert LA, et al. A randomized trial of cyclosporine in patients with steroid-resistant focal segmental glomerulosclerosis. North America Nephrotic Syndrome Study Group. Kidney Int. 1999;56:2220–6.\nPonticelli C, Rizzoni G, Edefonti A, et al. A randomized trial of cyclosporine in steroid-resistant idiopathic nephrotic syndrome. Kidney Int. 1993;43:1377–84.\nKlaassen I, Ozgoren B, Sadowski CE, et al. Response to cyclosporine in steroid-resistant nephrotic syndrome: discontinuation is possible. Pediatr Nephrol. 2015;30:1477–83.\nGellermann J, Weber L, Pape L, Tonshoff B, Hoyer P, Querfeld U. Gesellschaft fur Padiatrische N: Mycophenolate mofetil versus cyclosporin A in children with frequently relapsing nephrotic syndrome. J Am Soc Nephrol. 2013;24:1689–97. This prospective open-label crossover study compared the efficacy of mycophenolate mofetil and cyclosporine in children with frequently relapsing nephrotic syndrome. They found no relapses in 85 % of children treated with cyclosporine and 64 % of children treated with mycophenolate.\nIshikura K, Yoshikawa N, Nakazato H, et al. Two-year follow-up of a prospective clinical trial of cyclosporine for frequently relapsing nephrotic syndrome in children. Clin J Am Soc Nephrol. 2012;7:1576–83.\nHulton SA, Neuhaus TJ, Dillon MJ, Barratt TM. Long-term cyclosporin A treatment of minimal-change nephrotic syndrome of childhood. Pediatr Nephrol. 1994;8:401–3.\nPonticelli C, Edefonti A, Ghio L, et al. Cyclosporin versus cyclophosphamide for patients with steroid-dependent and frequently relapsing idiopathic nephrotic syndrome: a multicentre randomized controlled trial. Nephrol Dial Transplant. 1993;8:1326–32.\nNiaudet P. Comparison of cyclosporin and chlorambucil in the treatment of steroid-dependent idiopathic nephrotic syndrome: a multicentre randomized controlled trial. The French Society of Paediatric Nephrology. Pediatr Nephrol. 1992;6:1–3.\nEl-Husseini A, El-Basuony F, Mahmoud I, et al. Long-term effects of cyclosporine in children with idiopathic nephrotic syndrome: a single-centre experience. Nephrol Dial Transplant. 2005;20:2433–8.\nDittrich K, Knerr I, Rascher W, Dotsch J. Transient insulin-dependent diabetes mellitus in children with steroid-dependent idiopathic nephrotic syndrome during tacrolimus treatment. Pediatr Nephrol. 2006;21:958–61.\nIijima K, Hamahira K, Tanaka R, et al. Risk factors for cyclosporine-induced tubulointerstitial lesions in children with minimal change nephrotic syndrome. Kidney Int. 2002;61:1801–5.\nHogg RJ, Fitzgibbons L, Bruick J, et al. Mycophenolate mofetil in children with frequently relapsing nephrotic syndrome: a report from the Southwest Pediatric Nephrology Study Group. Clin J Am Soc Nephrol. 2006;1:1173–8.\nDorresteijn EM, Kist-van Holthe JE, Levtchenko EN, Nauta J, Hop WC, van der Heijden AJ. Mycophenolate mofetil versus cyclosporine for remission maintenance in nephrotic syndrome. Pediatr Nephrol. 2008;23:2013–20.\nBaudouin V, Alberti C, Lapeyraque AL, et al. Mycophenolate mofetil for steroid-dependent nephrotic syndrome: a phase II Bayesian trial. Pediatr Nephrol. 2012;27:389–96.\nCattran DC, Wang MM, Appel G, Matalon A, Briggs W. Mycophenolate mofetil in the treatment of focal segmental glomerulosclerosis. Clin Nephrol. 2004;62:405–11.\nGipson DS, Trachtman H, Kaskel FJ, et al. Clinical trial of focal segmental glomerulosclerosis in children and young adults. Kidney Int. 2011;80:868–78.\nAfzal K, Bagga A, Menon S, Hari P, Jordan SC. Treatment with mycophenolate mofetil and prednisolone for steroid-dependent nephrotic syndrome. Pediatr Nephrol. 2007;22:2059–65.\nHoeltzenbein M, Elefant E, Vial T, et al. Teratogenicity of mycophenolate confirmed in a prospective study of the European Network of Teratology Information Services. Am J Med Genet A. 2012;158A:588–96.\nFornoni A, Sageshima J, Wei C, et al. Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis. Sci Transl Med. 2011;3:85ra46.\nRavani P, Magnasco A, Edefonti A, et al. Short-term effects of rituximab in children with steroid- and calcineurin-dependent nephrotic syndrome: a randomized controlled trial. Clin J Am Soc Nephrol. 2011;6:1308–15.\nRuggenenti P, Ruggiero B, Cravedi P, et al. Rituximab in steroid-dependent or frequently relapsing idiopathic nephrotic syndrome. J Am Soc Nephrol. 2014;25:850–63.\nRavani P, Ponticelli A, Siciliano C, et al. Rituximab is a safe and effective long-term treatment for children with steroid and calcineurin inhibitor-dependent idiopathic nephrotic syndrome. Kidney Int. 2013;84:1025–33.\nIijima K, Sako M, Nozu K, et al. Rituximab for childhood-onset, complicated, frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet. 2014;384:1273–81. This randomized double-blind trial demonstrated that children with frequently relapsing or steroid dependent nephrotic syndrome treated with 4-weekly doses of rituximab had longer relapse-free survival compared to children who received placebo.\nRavani P, Rossi R, Bonanni A, Quinn RR, Sica F, Bodria M, Pasini A, Montini G, Edefonti A, Belingheri M, et al.: Rituximab in Children with Steroid-Dependent Nephrotic Syndrome: A Multicenter, Open-Label, Noninferiority, Randomized Controlled Trial. J Am Soc Nephrol 2015.\nMagnasco A, Ravani P, Edefonti A, et al. Rituximab in children with resistant idiopathic nephrotic syndrome. J Am Soc Nephrol. 2012;23:1117–24.\nPrytula A, Iijima K, Kamei K, et al. Rituximab in refractory nephrotic syndrome. Pediatr Nephrol. 2010;25:461–8.\nChaumais MC, Garnier A, Chalard F, et al. Fatal pulmonary fibrosis after rituximab administration. Pediatr Nephrol. 2009;24:1753–5.\nDeborska-Materkowska D, Kozinska-Przybyl O, Mikaszewska-Sokolewicz M, Durlik M. Fatal late-onset Pneumocystis pneumonia after rituximab: administration for posttransplantation recurrence of focal segmental glomerulosclerosis—case report. Transplant Proc. 2014;46:2908–11.\nKumar J, Shatat IF, Skversky AL, et al. Rituximab in post-transplant pediatric recurrent focal segmental glomerulosclerosis. Pediatr Nephrol. 2013;28:333–8.\nRiley CM. Nephrotic syndrome. Effect of adenocorticotrophic hormone. Pediatrics. 1951;7:457–71.\nSavin VJ, McCarthy ET, Sharma R, Charba D, Sharma M. Galactose binds to focal segmental glomerulosclerosis permeability factor and inhibits its activity. Transl Res. 2008;151:288–92.\nSgambat K, Banks M, Moudgil A. Effect of galactose on glomerular permeability and proteinuria in steroid-resistant nephrotic syndrome. Pediatr Nephrol. 2013;28:2131–5.\nDe Smet E, Rioux JP, Ammann H, Deziel C, Querin S. FSGS permeability factor-associated nephrotic syndrome: remission after oral galactose therapy. Nephrol Dial Transplant. 2009;24:2938–40.\nTrachtman H, Vento S, Herreshoff E, et al. Efficacy of galactose and adalimumab in patients with resistant focal segmental glomerulosclerosis: report of the font clinical trial group. BMC Nephrol. 2015;16:111.\nReiser J, von Gersdorff G, Loos M, et al. Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest. 2004;113:1390–7.\nYu CC, Fornoni A, Weins A, et al. Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med. 2013;369:2416–23.\nAlachkar N, Carter-Monroe N, Reiser J. Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med. 2014;370:1263–4.",{"VOID":896},"10.1007\u002Fs40746-016-0044-x","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs40746-016-0044-x",[899],{"id":900,"sortIndex":19,"researcher":18,"roles":901,"affiliations":902,"properties":911,"displayName":913,"givenName":18,"familyName":18},"6e3298d4-071f-4105-8771-d3c3167b542f",[117],[903],{"id":904,"sortIndex":19,"affiliation":905,"properties":18},"fecb1fb5-2b55-4f81-8d92-07fe0db1e233",{"id":904,"createTime":18,"updateTime":18,"relativeEntities":906,"slug":18,"properties":907,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":910,"statistic":18},[],{"title":908},{"VI":909},"Division of Pediatric Nephrology, University of Minnesota Masonic Children’s Hospital, Minneapolis, USA",[],{"title":912},{"VI":913},"Michelle N Rheault",{"url":897,"publisher":915,"properties":944},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":916,"slug":10,"properties":917,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":920,"manageAffiliations":925,"indexDatabases":931,"url":54,"thumbnailPath":18,"statistic":939,"gsStatistic":18,"type":86,"analyzePriority":18},[],{"issn":918,"title":919},{"VOID":13},{"EN":15},[921],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":922,"label":923,"description":924,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[926],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":927,"slug":18,"properties":928,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":930,"statistic":18},[],{"title":929},{"EN":33},[35],[932],{"id":38,"indexDatabase":933,"url":49,"indexYears":50,"academicFieldIds":938,"indexDatabaseRanking":53},{"id":40,"createTime":18,"updateTime":18,"relativeEntities":934,"label":935,"description":936,"key":46,"publicationTags":937,"standard":18},[],{"EN":43,"VI":43},{"EN":43,"VI":45},[48],[52],{"impactFactor":19,"impactFactorByYear":940,"i10Index":62,"i10IndexLast5Year":62,"totalPublication":63,"totalPublicationByYear":941,"totalCitation":74,"totalCitationByYear":942,"totalCitationPerPublication":80,"totalCitationPerPublicationByYear":943,"hindexLast5Year":76,"hindex":76},{"2017":57,"2020":58,"2021":59,"2022":60,"2023":61},{"2014":65,"2015":66,"2016":67,"2017":68,"2018":69,"2019":70,"2020":71,"2021":72,"2022":73,"2023":72},{"2015":76,"2016":77,"2018":65,"2019":78,"2020":79,"2021":76},{"2015":82,"2016":83,"2018":57,"2019":84,"2020":85,"2021":80},{"pages":945,"volume":947},{"VOID":946},"94-103",{"VOID":701},"2016-03-18",[53],{"id":951,"createTime":952,"updateTime":953,"relativeEntities":954,"slug":955,"properties":956,"entityType":108,"verifyStatus":109,"verifyTime":953,"verifyNote":111,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":965,"fullTextUrl":18,"authors":966,"publicationType":139,"publisherRelationship":1068,"citationCount":18,"citationInfo":18,"publishDate":1103,"publishYear":1104,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":1105,"openAccess":18,"references":18,"isForceReanalyzing":181},"d046e3ff-392e-48ef-b304-a440b5795bef","2023-12-05T13:33:15.341+00:00","2025-02-23T08:38:40.603+00:00",[],"Patient-Safety-What-Is-Working-and-Why-",{"abstract":957,"title":959,"references":961,"doi":963},{"EN":958},"Our goal is to review a number of methodologies which have been used to improve safety in healthcare since the release of the Institute of Medicine report in 1998 which documented that error was a significant cause of mortality in the USA. Multifaceted approaches have each led to reduction in error. Methods for error reduction included in this review are “Just Culture,” increased transparency and accountability, error reporting and investigation, second-victim programs, training in quality and safety methods, standardization and bundles, electronic health records, computerized order entry, barcode scanning, clinical decision support, predictive analytics, and situational awareness. Newer fields with the potential to improve patient safety include human factors engineering, indication-based prescribing, and Safety II. While each intervention has led to incremental improvement, continued expansion of these programs is necessary to eliminate medical error.",{"EN":960},"Patient Safety: What Is Working and Why?",{"VOID":962},"Kohn LT, Corrigan J, Donaldson MS, Institute of Medicine (U.S.). Committee on Quality of Health Care in America. To err is human: building a safer health system. 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SEIPS 2.0: a human factors framework for studying and improving the work of healthcare professionals and patients. Ergonomics. 2013;56(11):1669–86. https:\u002F\u002Fdoi.org\u002F10.1080\u002F00140139.2013.838643.\nSchiff GD, Seoane-Vazquez E, Wright A. Incorporating indications into medication ordering--time to enter the age of reason. N Engl J Med. 2016;375(4):306–9. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMp1603964.\nFalck S, Adimadhyam S, Meltzer DO, Walton SM, Galanter WL. A trial of indication based prescribing of antihypertensive medications during computerized order entry to improve problem list documentation. Int J Med Inform. 2013;82(10):996–1003. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijmedinf.2013.07.003.\nGalanter W, Falck S, Burns M, Laragh M, Lambert BL. Indication-based prescribing prevents wrong-patient medication errors in computerized provider order entry (CPOE). J Am Med Inform Assoc. 2013;20(3):477–81. https:\u002F\u002Fdoi.org\u002F10.1136\u002Famiajnl-2012-001555.\nWalton SM, Galanter WL, Rosencranz H, Meltzer D, Stafford RS, Tiryaki F, et al. A trial of inpatient indication based prescribing during computerized order entry with medications commonly used off-label. Appl Clin Inform. 2011;2(1):94–103. https:\u002F\u002Fdoi.org\u002F10.4338\u002FACI-2010-11-RA-0072.\nIs an Indication-Based Prescribing System in Our Future? Institute for Safe Medication Practices. https:\u002F\u002Fwww.ismp.org\u002Fresources\u002Findication-based-prescribing-system-our-future. Accessed October 22, 2018.\n• Hollnagel E, Wears R, Braithwaite J. From Safety I to Safety II: a white paper. 2015.This white paper outlines the principles of Safety II and points a way forward toward improved patient safety.\nClay-Williams R, Hounsgaard J, Hollnagel E. Where the rubber meets the road: using FRAM to align work-as-imagined with work-as-done when implementing clinical guidelines. Implement Sci. 2015;10:125. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs13012-015-0317-y.\nGrant S, Guthrie B. Efficiency and thoroughness trade-offs in high-volume organisational routines: an ethnographic study of prescribing safety in primary care. BMJ Qual Saf. 2018;27(3):199–206. https:\u002F\u002Fdoi.org\u002F10.1136\u002Fbmjqs-2017-006917.\nHolden RJ, Rivera-Rodriguez AJ, Faye H, Scanlon MC, Karsh BT. Automation and adaptation: Nurses’ problem-solving behavior following the implementation of bar coded medication administration technology. Cogn Tech Work. 2013;15(3):283–96. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs10111-012-0229-4.\nFairbanks RJ, Wears RL, Woods DD, Hollnagel E, Plsek P, Cook RI. Resilience and resilience engineering in health care. Jt Comm J Qual Patient Saf. 2014;40(8):376–83.\nMerandi J, Vannatta K, Davis JT, McClead RE, Brilli R, Bartman T. Safety II behavior in a pediatric intensive care unit. Pediatrics. 2018;141(6):e20180018. https:\u002F\u002Fdoi.org\u002F10.1542\u002Fpeds.2018-0018.",{"VOID":964},"10.1007\u002Fs40746-019-00156-5","http:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs40746-019-00156-5",[967,991,1006,1024,1046],{"id":968,"sortIndex":19,"researcher":18,"roles":969,"affiliations":970,"properties":988,"displayName":990,"givenName":18,"familyName":18},"a8be544a-730d-4d5d-9383-ad0d857fe960",[117],[971,979],{"id":972,"sortIndex":19,"affiliation":973,"properties":18},"58ae5fc9-09a9-4cfd-98ce-88344671f72b",{"id":972,"createTime":18,"updateTime":18,"relativeEntities":974,"slug":18,"properties":975,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":978,"statistic":18},[],{"title":976},{"VI":977},"Quality Improvement Services, Nationwide Children’s Hospital, Columbus, USA",[],{"id":980,"sortIndex":65,"affiliation":981,"properties":987},"1587992f-40a9-4971-a665-be63a93b8008",{"id":980,"createTime":18,"updateTime":18,"relativeEntities":982,"slug":18,"properties":983,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":986,"statistic":18},[],{"title":984},{"VI":985},"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, USA",[],{},{"title":989},{"VI":990},"Thomas Bartman",{"id":992,"sortIndex":65,"researcher":18,"roles":993,"affiliations":994,"properties":1003,"displayName":1005,"givenName":18,"familyName":18},"9625923f-39da-47a9-8f35-2e03a80164af",[117],[995],{"id":996,"sortIndex":19,"affiliation":997,"properties":18},"3a1d7b6f-398d-4833-96d6-878ece233f8c",{"id":996,"createTime":18,"updateTime":18,"relativeEntities":998,"slug":18,"properties":999,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1002,"statistic":18},[],{"title":1000},{"VI":1001},"Clinical Fellowship in Quality and Safety Leadership, Nationwide Children’s Hospital, Columbus, USA",[],{"title":1004},{"VI":1005},"C. 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Bode",{"url":965,"publisher":1069,"properties":1098},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1070,"slug":10,"properties":1071,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1074,"manageAffiliations":1079,"indexDatabases":1085,"url":54,"thumbnailPath":18,"statistic":1093,"gsStatistic":18,"type":86,"analyzePriority":18},[],{"issn":1072,"title":1073},{"VOID":13},{"EN":15},[1075],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":1076,"label":1077,"description":1078,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[1080],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":1081,"slug":18,"properties":1082,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1084,"statistic":18},[],{"title":1083},{"EN":33},[35],[1086],{"id":38,"indexDatabase":1087,"url":49,"indexYears":50,"academicFieldIds":1092,"indexDatabaseRanking":53},{"id":40,"createTime":18,"updateTime":18,"relativeEntities":1088,"label":1089,"description":1090,"key":46,"publicationTags":1091,"standard":18},[],{"EN":43,"VI":43},{"EN":43,"VI":45},[48],[52],{"impactFactor":19,"impactFactorByYear":1094,"i10Index":62,"i10IndexLast5Year":62,"totalPublication":63,"totalPublicationByYear":1095,"totalCitation":74,"totalCitationByYear":1096,"totalCitationPerPublication":80,"totalCitationPerPublicationByYear":1097,"hindexLast5Year":76,"hindex":76},{"2017":57,"2020":58,"2021":59,"2022":60,"2023":61},{"2014":65,"2015":66,"2016":67,"2017":68,"2018":69,"2019":70,"2020":71,"2021":72,"2022":73,"2023":72},{"2015":76,"2016":77,"2018":65,"2019":78,"2020":79,"2021":76},{"2015":82,"2016":83,"2018":57,"2019":84,"2020":85,"2021":80},{"pages":1099,"volume":1101},{"VOID":1100},"131-144",{"VOID":1102},"5","2019-04-11",2019,[53],{"id":1107,"createTime":1108,"updateTime":1109,"relativeEntities":1110,"slug":1111,"properties":1112,"entityType":108,"verifyStatus":109,"verifyTime":1109,"verifyNote":111,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1121,"fullTextUrl":18,"authors":1122,"publicationType":139,"publisherRelationship":1153,"citationCount":18,"citationInfo":18,"publishDate":1187,"publishYear":357,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":1188,"openAccess":18,"references":18,"isForceReanalyzing":181},"71341f00-08d9-4bc0-b306-96b6e7e4c54c","2024-01-22T13:49:31.262+00:00","2025-02-23T07:33:54.565+00:00",[],"Prevention-of-CAUTIs-CLABSIs-and-VAPs-in-Children",{"abstract":1113,"title":1115,"references":1117,"doi":1119},{"EN":1114},"Given the lack of randomized controlled trials or robust literature in children, we are left with recommended bundles, adult-based literature, and common sense. The quality improvement approach to studying prevention of hospital-acquired infections through the use of bundles has generally been studied en masse, rather than by individual bundle elements. Due to the mortality risk, indirect and direct attributable costs, and the inevitable penalties associated with these largely preventable harms, we must reliably implement bundles to avoid these hospital-acquired infections. ”Implementation is the most difficult but most essential aspect of harm prevention”. The journey to zero harm, whether infectious or not, will ultimately require a robust safety culture, incorporation of high reliability principles, and patient and family engagement.",{"EN":1116},"Prevention of CAUTIs, CLABSIs, and VAPs in Children",{"VOID":1118},"Klevens RM, Edwards JR, Richards CL, Horan TC, Gaynes RP, Pollock DA, et al. Estimating health care-associated infections and deaths in U.S. hospitals, 2002. Public Health Rep Wash DC 1974. 2007;122(2):160–6. doi:10.1177\u002F003335490712200205.\nMagill SS, Edwards JR, Bamberg W, Beldavs ZG, Dumyati G, Kainer MA, et al. Multistate point-prevalence survey of health care-associated infections. N Engl J Med. 2014;370(13):1198–208. doi:10.1056\u002FNEJMoa1306801.\nRichards MJ, Edwards JR, Culver DH, et al. Nosocomial infections in pediatric intensive care units in the United States. National Nosocomial Infections Surveillance System. Pediatrics. 1999;103(4):e39.\nZingg W, Hopkins S, Gayet-Ageron A, Holmes A, Sharland M, Suetens C, et al. Health-care-associated infections in neonates, children, and adolescents: an analysis of pediatric data from the European Centre for Disease Prevention and Control point-prevalence survey. Lancet Infect Dis. 2017;17:381–9.\nHow it all started. Solutions for Patient Safety. http:\u002F\u002Fwww.solutionsforpatientsafety.org\u002Fabout-us\u002Fhow-it-all-started. Accessed 1 May 2017.\n•• SPS prevention bundles. Solutions for Patient Safety; 2017. http:\u002F\u002Fwww.solutionsforpatientsafety.org\u002Fwp-content\u002Fuploads\u002FSPS-Prevention-Bundles.pdf. Accessed 1 May 2017. SPS has published pediatric-specific bundles for prevention of hospital-acquired harm.\nOperational definitions. Solutions for Patient Safety; 2017. http:\u002F\u002Fwww.solutionsforpatientsafety.org\u002Fwp-content\u002Fuploads\u002Fsps-operating-definitions.pdf. Accessed 1 May 2017.\nBloodstream infection event. CDC. January 2017. https:\u002F\u002Fwww.cdc.gov\u002Fnhsn\u002Fpdfs\u002Fpscmanual\u002F4psc_clabscurrent.pdf. Accessed 5 Jun 2017.\nUrinary tract infection. CDC. January 2017. https:\u002F\u002Fwww.cdc.gov\u002Fnhsn\u002Fpdfs\u002Fpscmanual\u002F7psccauticurrent.pdf. Accessed 5 Jun 2017.\nVentilator-associated event. January 2017. https:\u002F\u002Fwww.cdc.gov\u002Fnhsn\u002Fpdfs\u002Fpscmanual\u002F10-vae_final.pdf. Accessed 5 Jun 2017.\nCocoros NM, Priebe GP, Logan LK, Coffin S, Larsen G, Toltzis P, et al. A Pediatric Approach to Ventilator-Associated Events Surveillance. Infect Control Hosp Epidemiol. 2017;38(3):327–33. doi:10.1017\u002Fice.2016.277.\nPneumonia Event. January 2017. https:\u002F\u002Fwww.cdc.gov\u002Fnhsn\u002Fpdfs\u002Fpscmanual\u002F6pscvapcurrent.pdf. Accessed 5 Jun 2017.\nUmscheid CA, Mitchell MD, Doshi JA, Agarwal R, Williams K, Brennan PJ. Estimating the Proportion of Healthcare-Associated Infections That Are Reasonably Preventable and the Related Mortality and Costs. Infect Control Hosp Epidemiol. 2011;32(02):101–14. doi:10.1086\u002F657912.\nBest D, Osterkamp E, Demmel K, Kiniyalocts S, Mock S, Mulligan K, et al. Increasing Activities of Daily Living Is as Easy as 1–2-3. J Pediatr Oncol Nurs. 2016;33(5):345–52. doi:10.1177\u002F1043454215616607.\nLalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, et al. MASCC\u002FISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2014;120(10):1453–61. doi:10.1002\u002Fcncr.28592.\nOral cryotherapy for oral mucositis in patients receiving chemotherapy. Cincinnati children’s hospital medical center; 2013. https:\u002F\u002Fwww.cincinnatichildrens.org\u002Fservice\u002Fj\u002Fanderson-center\u002Fevidence-based-care\u002Frecommendations\u002Ftopic. Accessed 1 May 2017.\nZimlichman E, Henderson D, Tamir O, Franz C, Song P, Yamin CK, et al. Health care-associated infections: a meta-analysis of costs and financial impact on the US health care system. JAMA Intern Med. 2013;173(22):2039–46. doi:10.1001\u002Fjamainternmed.2013.9763.\nScott II RD. The direct medical costs of healthcare-associated infections in U.S. hospitals and the benefits of prevention. Division of Healthcare Quality Promotion, National Center for Preparedness, Detection, and Control of Infectious Diseases. Centers for Disease Control and Prevention; 2009. https:\u002F\u002Fwww.cdc.gov\u002Fhai\u002Fpdfs\u002Fhai\u002Fscott_costpaper.pdf. Accessed 1 May 2017.\nGoudie A, Dynan L, Brady PW, Rettiganti M. Attributable cost and length of stay for central line-associated bloodstream infections. Pediatrics. 2014;133(6):e1525–32. doi:10.1542\u002Fpeds.2013-3795.\nNowak JE, Brilli RJ, Lake MR, Sparling KW, Butcher J, Schulte M, et al. Reducing catheter-associated bloodstream infections in the pediatric intensive care unit: Business case for quality improvement. Pediatr Crit Care Med. 2010;11(5):579–87. doi:10.1097\u002FPCC.0b013e3181d90569.\nElward AM, Hollenbeak CS, Warren DK, et al. Attributable cost of nosocomial primary bloodstream infection in pediatric intensive care unit patients. Pediatrics. 2005;115(4):868–72.\nBrilli R, Sparling K, Lake M, et al. The business case for preventing ventilator-associated pneumonia in pediatric intensive care unit patients. Jt Comm J Qual Patient Saf. 2008;34(11):629–38.\nGoudie A, Dynan L, Brady PW, Fieldston E, Brilli RJ, Walsh KE. Costs of Venous Thromboembolism, Catheter-Associated Urinary Tract Infection, and Pressure Ulcer. Pediatrics. 2015;136(3):432–9. doi:10.1542\u002Fpeds.2015-1386.\nResar R, Griffin F, Haraden C, et al. Using care bundles to improve health care quality. IHI Innovation Series white paper. Cambridge: Institute for Healthcare Improvement; 2012. http:\u002F\u002Fwww.ihi.org\u002Fresources\u002FPages\u002FIHIWhitePapers\u002FUsingCareBundles.aspx. Accessed 1 May 2017\nHow-to Guide. Prevent Ventilator-Associated Pneumonia. Cambridge, MA: Institute for Healthcare Improvement; 2012. http:\u002F\u002Fwww.ihi.org\u002Fresources\u002FPages\u002FTools\u002FHowtoGuidePreventVAP.aspx. Accessed 1 May 2017\nHow-to Guide. Prevent Central Line-Associated Bloodstream Infections. Cambridge, MA: Institute for Healthcare Improvement; 2012. http:\u002F\u002Fwww.ihi.org\u002Fresources\u002FPages\u002FTools\u002FHowtoGuidePreventCentralLineAssociatedBloodstreamInfection.aspx. Accessed 1 May 2017\nHow-to Guide. Prevent Catheter-Associated Urinary Tract Infections. Cambridge, MA: Institute for Healthcare Improvement; 2012. http:\u002F\u002Fwww.ihi.org\u002Fresources\u002FPages\u002FTools\u002FHowtoGuidePreventCatheterAssociatedUrinaryTractInfection.aspx. Accessed 1 May 2017\nLachman P, Yuen S. Using care bundles to prevent infection in neonatal and pediatric ICUs. Curr Opin Infect Dis. 2009;22(3):224–8. doi:10.1097\u002FQCO.0b013e3283297b68.\nSevere sepsis bundles. Institute fxor Healthcare Improvement; 2013. http:\u002F\u002Fwww.ihi.org\u002Fresources\u002FPages\u002FTools\u002FSevereSepsisBundles.aspx. Accessed 1 May 2017.\nHow-to guide: Prevent obstetrical adverse events. Institute for Healthcare Improvement; 2012. http:\u002F\u002Fwww.ihi.org\u002Fresources\u002FPages\u002FTools\u002FHowtoGuidePreventObstetricalAdverseEvents.aspx. Accessed 1 May 2017.\nHuskins WC. Quality improvement interventions to prevent healthcare-associated infections in neonates and children. Curr Opin Pediatr. 2012;24(1):103–12. doi:10.1097\u002FMOP.0b013e32834ebdc3.\nSmulders CA, van Gestel JPJ, Bos AP. Are central line bundles and ventilator bundles effective in critically ill neonates and children? Intensive Care Med. 2013;39(8):1352–8. doi:10.1007\u002Fs00134-013-2927-7.\nFisher D, Cochran KM, Provost LP, Patterson J, Bristol T, Metzguer K, et al. Reducing central line-associated bloodstream infections in North Carolina NICUs. Pediatrics. 2013;132(6):e1664–71. doi:10.1542\u002Fpeds.2013-2000.\nWang W, Zhao C, Ji Q, Liu Y, Shen G, Wei L. Prevention of peripherally inserted central line-associated blood stream infections in very low-birth-weight infants by using a central line bundle guideline with a standard checklist: a case control study. BMC Pediatr. 2015;15:69. doi:10.1186\u002Fs12887-015-0383-y.\nSteiner M, Langgartner M, Cardona F, Waldhör T, Schwindt J, Haiden N, et al. Significant Reduction of Catheter-associated Blood Stream Infections in Preterm Neonates After Implementation of a Care Bundle Focusing on Simulation Training of Central Line Insertion. Pediatr Infect Dis J. 2015;34(11):1193–6. doi:10.1097\u002FINF.0000000000000841.\nResende DS, Peppe ALG, dos Reis H, Abdallah VOS, Ribas RM, Gontijo Filho PP. Late onset sepsis in newborn babies: epidemiology and effect of a bundle to prevent central line associated bloodstream infections in the neonatal intensive care unit. Braz J Infect Dis. 2015;19(1):52–7. doi:10.1016\u002Fj.bjid.2014.09.006.\nCeballos K, Waterman K, Hulett T, Makic MBF. Nurse-driven quality improvement interventions to reduce hospital-acquired infection in the NICU. Adv Neonatal Care. 2013;13(3):154–163; quiz 164–5. doi:10.1097\u002FANC.0b013e318285fe70.\nJeong IS, Park SM, Lee JM, Song JY, Lee SJ. Effect of central line bundle on central line-associated bloodstream infections in intensive care units. Am J Infect Control. 2013;41(8):710–6. doi:10.1016\u002Fj.ajic.2012.10.010.\nGrover TR, Pallotto EK, Brozanski B, Piazza AJ, Chuo J, Moran S, et al. Interdisciplinary teamwork and the power of a quality improvement collaborative in tertiary neonatal intensive care units. J Perinat Neonatal Nurs. 2015;29(2):179–86. doi:10.1097\u002FJPN.0000000000000102.\nO’Grady N, Alexander M, Burns L, Dellinger P, Garland J, Heard S, et al. Guidelines for the prevention of intravascular catheter-related infections, 2011. Centers for Disease Control and Prevention. 2011. https:\u002F\u002Fwww.cdc.gov\u002Fhai\u002Fpdfs\u002Fbsi-guidelines-2011.pdf. Accessed 1 May 2017.\nChecklist for prevention of central line associated blood stream infections. Centers for Disease Control and Prevention. National Center for Emerging and Zoonotic Infectious Diseases. Division of Healthcare Quality Promotion. https:\u002F\u002Fwww.cdc.gov\u002Fhai\u002Fpdfs\u002Fbsi\u002Fchecklist-for-clabsi.pdf. Accessed 1 May 2017.\nBarnes S, Olmsted R, Monsees E, et al. Guide to preventing central line-associated bloodstream infections. Association for Professionals in Infection Control and Epidemiology. 2015. http:\u002F\u002Fapic.org\u002FResource_\u002FTinyMceFileManager\u002F2015\u002FAPIC_CLABSI_WEB.pdf. Accessed 1 May 2017.\nBest practice guidelines in the care and maintenance of pediatric central venous catheters. 2nd ed. Pediatric Special Interest Group of AVA; 2015.\n• Gorski L, Hadaway L, Hagle ME, et al. Infusion therapy standards of practice. J Infus Nurs. 2016;39(suppl1):S1–S159. Frequently referenced source for CLABSI prevention guidelines.\nPeripherally inserted central catheters: Guidelines for practice. 3rd ed. National Association of Neonatal Nurses, 2015.\nGould C, Umscheid C, Agarwal R, et al. Guideline for prevention of catheter-associated urinary tract infections 2009. Healthcare Infection Control Practices Advisory Committee. Centers for Disease Control and Prevention. 2009. https:\u002F\u002Fwww.cdc.gov\u002Fhai\u002Fpdfs\u002Fcautiguideline2009final.pdf. Accessed 1 May 2017.\nFelix K, Bellush MJ, Bor B. Guide to preventing catheter-associated urinary tract infections. Association for Professionals in Infection Control and Epidemiology. 2014. http:\u002F\u002Fapic.org\u002FResource_\u002FEliminationGuideForm\u002F0ff6ae59-0a3a-4640-97b5-eee38b8bed5b\u002FFile\u002FCAUTI_06.pdf. Accessed 1 May 2017.\nInstitute for Healthcare Improvement. How to guide pediatric supplement: ventilator-associated pneumonia 2012. http:\u002F\u002Fwww..org\u002Fresources\u002FPages\u002FTools\u002FHowtoGuidePreventVAPPediatricSupplement.aspx. Accessed 1 May 2017.\nGreene L, Sposato K. Guide to the elimination of ventilator-associated pneumonia. Association for Professionals in Infection Control and Epidemiology. 2009. http:\u002F\u002Fwww.apic.org\u002FResource_\u002FEliminationGuideForm\u002F18e326ad-b484-471c-9c35-6822a53ee4a2\u002FFile\u002FVAP_09.pdf. Accessed 1 May 2017.\n• Klompas M, Branson R, Eichenwald EC, Greene LR, Howell MD, Lee G, et al. Strategies to prevent ventilator-associated pneumonia in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol. 2014;35(Suppl 2):S133–54. Specifically examines evidence for VAP prevention in children and neonates.\nMuszynski JA, Sartori J, Steele L, Frost R, Wang W, Khan N, et al. Multidisciplinary quality improvement initiative to reduce ventilator-associated tracheobronchitis in the PICU. Pediatr Crit Care Med. 2013;14(5):533–8. doi:10.1097\u002FPCC.0b013e31828a897f.\nBigham MT, Amato R, Bondurrant P, Fridriksson J, Krawczeski CD, Raake J, et al. Ventilator-associated pneumonia in the pediatric intensive care unit: characterizing the problem and implementing a sustainable solution. J Pediatr. 2009;154(4):582–587.e2. doi:10.1016\u002Fj.jpeds.2008.10.019.\nZhou Q, Lee SK, Jiang S, Chen C, Kamaluddeen M, Hu X, et al. Efficacy of an infection control program in reducing ventilator-associated pneumonia in a Chinese neonatal intensive care unit. Am J Infect Control. 2013;41(11):1059–64. doi:10.1016\u002Fj.ajic.2013.06.007.\nAzab SFA, Sherbiny HS, Saleh SH, Elsaeed WF, Elshafiey MM, Siam AG, et al. Reducing ventilator-associated pneumonia in neonatal intensive care unit using “VAP prevention Bundle”: a cohort study. BMC Infect Dis. 2015;15:314. doi:10.1186\u002Fs12879-015-1062-1.\nDavis KF, Colebaugh AM, Eithun BL, Klieger SB, Meredith DJ, Plachter N, et al. Reducing catheter-associated urinary tract infections: a quality-improvement initiative. Pediatrics. 2014;134(3):e857–64. doi:10.1542\u002Fpeds.2013-3470.\nPatrick SW, Kawai AT, Kleinman K, Jin R, Vaz L, Gay C, et al. Health Care-Associated Infections Among Critically Ill Children in the US, 2007–2012. Pediatrics. 2014;134:705–12.\nWeber DJ, Kanamori H, Rutala WA. ‘No touch’ technologies for environmental decontamination: focus on ultraviolet devices and hydrogen peroxide systems. Curr Opin Infect Dis. 2016;29(4):424–31. doi:10.1097\u002FQCO.0000000000000284.\nBoyce J. Modern technologies for improving cleaning and disinfection of environmental surfaces at hospitals. Antimicrob Resist Infect Control. 2016;5:10. doi:10.1186\u002Fs13756-016-0111-x.\nSchmidt MG, Attaway HH, Sharpe PA, John J Jr, Sepkowitz KA, Morgan A, et al. Sustained reduction of microbial burden on common hospital surfaces through introduction of copper. J Clin Microbiol. 2012;50:2217–23.\nSchmidt MG, Attaway HH, Fairey SE, Steed LL, Michels HT, Salgado CD. Copper continuously limits the concentration of bacteria resident on bed rails within the intensive care unit. Infect Control Hosp Epidemiol. 2013;34:530–3.\nSalgado CD, Sepkowitz KA, John JF, Cantey JR, Attaway HH, Freeman KD, et al. Copper surfaces reduce the rate of healthcare-acquired infections in the intensive care unit. Infect Control Hosp Epidemiol. 2013;34:479–86.\nMezoff EA, Fei L, Troutt M, Klotz K, Kocoshis SA, Cole CR. Ethanol lock efficacy and associated complications in children with intestinal failure. JPEN. 2016;40(6):815–9. doi:10.1177\u002F0148607115574745.\nKawano T, Taji T, Onishi S, Yamada W, Nakame K, Mukai M, et al. Efficacy of ethanol locks to reduce the incidence of catheter-related bloodstream infections for home parenteral nutrition pediatric patients: comparison of therapeutic treatment with prophylactic treatment. Pediatr Surg Int. 2016;32(9):863–7.\nLandry DL, Jaber RA, Hanumanthappa N, Lipkowitz GS, O’Shea MH, Bermudez H, et al. Effects of prolonged ethanol lock exposure to carbothane- and silicone-based hemodialysis catheters: a 26-week study. J Vasc Access. 2015;16(5):367–71. doi:10.5301\u002Fjva.5000397.\nVoor In ‘t Holt AF, Helder OK, Vos MC, Schafthuizen L, Sülz S, van den Hoogen A, et al. Antiseptic barrier cap effective in reducing central line-associated bloodstream infections: A systematic review and meta-analysia. Int J Nurs Stud. 2017;69:34–40. doi:10.1016\u002Fj.ijnurstu.2017.01.007.\nRupp ME, Cavalieri RJ, Lyden E, Kucera J, Martin M, Fitzgerald T, et al. Effect of hospital-wide chlorhexidine patient bathing on healthcare-associated infections. Infect Control Hosp Epidemiol. 2012;33(11):1094–100. doi:10.1086\u002F668024.\nDerde LP, Dautzenberg MJ, Bonten MJ. Chlorhexidine body washing to control antimicrobial-resistant bacteria in intensive care units: a systematic review. Intensive Care Med. 2012;28(6):931–9. doi:10.1007\u002Fs00134-012-2542-z.\nKarki S, Cheng AC. Impact of chlorhexidine washcloths on healthcare-associated infections: do the recent trials add to the evidence? J Hosp Infect. 2013;84(3):266–7. doi:10.1016\u002Fj.jhin.2013.04.006.\nO’Horo JC, Silva GLM, Munoz-Price LS, Safdar N. The efficacy of daily bathing with chlorhexidine for reducing healthcare-associated bloodstream infections: a meta-analysis. Infect Control Hosp Epidemiol. 2012;33(3):257–67. doi:10.1086\u002F664496.\nSievert D, Armola R, Halm MA. Chlorhexidine gluconate bathing: does it decrease hospital-acquired infections? Am J Crit Care. 2011;20(2):166–70. doi:10.4037\u002Fajcc2011841.\nMunoz-Price LS, Dezfulian C, Wyckoff M, Lenchus JD, Rosalsky M, Birnbach DJ, et al. Effectiveness of stepwise interventions targeted to decrease central catheter-associated bloodstream infections. Crit Care Med. 2012;40(5):1464–9. doi:10.1097\u002FCCM.0b013e31823e9f5b.\nLopez AC. A quality improvement program combining maximal barrier precaution compliance monitoring and daily chlorhexidine baths resulting in decreased central line bloodstream infections. Dimens Crit Care Nurs. 2011;30(5):293–8. doi:10.1097\u002FDCC.0b013e318227767f.\nMontecalvo MA, McKenna D, Yarrish R, Mack L, Maguire G, Haas J, et al. Chlorhexidine bathing to reduce central venous catheter-associated bloodstream infection: impact and sustainability. Am J Med. 2012;125(5):505–11. doi:10.1016\u002Fj.amjmed.2011.10.032.\nLee A, Harlan R, Breaud AR, Speck K, Perl TM, Clarke W, et al. Blood concentrations of chlorhexidine in hospitalized children undergoing daily chlorhexidine bathing. Infect Control Hosp Epidemiol. 2011;32(4):395–7. doi:10.1086\u002F659154.\nRitz J, Pashink B, Padula C, et al. Effectiveness of 2 methods of chlorhexidine bathing. J Nurs Care Qual. 2012;27(2):171–5. doi:10.1097\u002FNCQ.0b013e3182398568.\nMilstone AM, Elward A, Song X, Zerr DM, Orscheln R, Speck K, et al. Daily chlorhexidine bathing to reduce bacteraemia in critically ill children: a multicentre, cluster-randomized, crossover trial. Lancet Lond Engl. 2013;381(9872):1099–106. doi:10.1016\u002FS0140-6736(12)61687-0.\nClimo MW, Yokoe DS, Warren DK, Perl TM, Bolon M, Herwaldt LA, et al. Effect of Daily Chlorhexidine Bathing on Hospital-Acquired Infection. N Engl J Med. 2013;368(6):533–42. doi:10.1056\u002FNEJMoa1113849.\nMendes ET, Ranzani OT, Marchi AP, de Silva MT, Filho JUA, Alves T, et al. Chlorhexidine bathing for the prevention of colonization and infection with multidrug-resistant microorganisms in a hematopoietic stem cell transplantation unit over a 9-year period. Medicine. 2016;95:46.\nLee YSH, Stone PW, Pogorzelska-Maziarz M, Nembhard IM. Differences in work environment for staff as an explanation for variation in central line bundle compliance in intensive care units. Health Care Manag Rev. 2016; doi:10.1097\u002FHMR.0000000000000134.\nShaw SJ, Jacobs B, Stockwell DC, Futterman C, Spaeder MC. Effect of a Real-Time Pediatric ICU Safety Bundle Dashboard on Quality Improvement Measures. Jt Comm J Qual Patient Saf. 2015;41(9):414–20. doi:10.1016\u002FS1553-7250(15)41053-0.\nPageler NM, Longhurst CA, Wood M, Cornfield DN, Suermondt J, Sharek PJ, et al. Use of electronic medical record-enhanced checklist and electronic dashboard to decrease CLABSIs. 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