[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_4ccf1f39-0b04-4e97-9718-65b946a6e8a0":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:4ccf1f39-0b04-4e97-9718-65b946a6e8a0,\"}":107},{"code":4,"data":5,"meta":18},"SUCCESS",{"id":6,"createTime":7,"updateTime":8,"relativeEntities":9,"slug":10,"properties":11,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":20,"manageAffiliations":37,"indexDatabases":60,"url":18,"thumbnailPath":18,"statistic":100,"gsStatistic":18,"type":106,"analyzePriority":18},"4ccf1f39-0b04-4e97-9718-65b946a6e8a0","2024-04-10T01:51:24.125+00:00","2025-11-21T09:46:58.640+00:00",[],"Current-Genetics",{"issn":12,"title":14},{"VOID":13},"14320983",{"VOID":15},"Current Genetics","PUBLISHER","PENDING",null,0,[21,29],{"id":22,"createTime":23,"updateTime":24,"relativeEntities":25,"label":26,"description":28,"parentId":18,"standard":18,"scholarHubFieldId":18},"0254e3e5-c28d-4a33-83da-81bc94d29ffd","2023-05-29T10:24:00.931+00:00","2023-11-21T07:56:41.438+00:00",[],{"EN":27},"Medicine (miscellaneous)",{},{"id":30,"createTime":31,"updateTime":32,"relativeEntities":33,"label":34,"description":36,"parentId":18,"standard":18,"scholarHubFieldId":18},"5815288e-6c9a-443e-9993-d3989541283b","2023-05-29T10:24:27.336+00:00","2023-11-21T07:15:31.374+00:00",[],{"EN":35},"Genetics",{},[38,51],{"id":39,"createTime":40,"updateTime":41,"relativeEntities":42,"slug":43,"properties":44,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":48,"url":18,"parentIds":49,"statistic":18},"6b6d67d8-1887-4ca8-86c5-a38f66f10928","2023-05-29T10:24:09.947+00:00","2025-11-21T10:07:51.595+00:00",[],"Springer-Verlag",{"title":45},{"EN":46},"Springer Verlag","AFFILIATION",12,[50],"9a7c7208-b28a-42c2-a634-5a7f90eee3ab",{"id":52,"createTime":53,"updateTime":54,"relativeEntities":55,"slug":56,"properties":57,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"url":18,"parentIds":59,"statistic":18},"26a19206-5cad-4456-bb2f-49abd254fbc6","2024-04-19T01:59:34.612+00:00","2025-11-21T10:06:47.646+00:00",[],"SPRINGER",{"title":58},{"EN":56},[],[61,81],{"id":62,"indexDatabase":63,"url":75,"indexYears":76,"academicFieldIds":77,"indexDatabaseRanking":80},"277f9617-571d-44d9-970e-62b8da99d6cc",{"id":64,"createTime":65,"updateTime":66,"relativeEntities":67,"label":68,"description":70,"key":72,"publicationTags":73,"standard":18},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9","2023-05-22T09:57:18.509+00:00","2025-11-21T10:07:52.274+00:00",[],{"EN":69,"VI":69},"Scopus - Elsevier",{"EN":69,"VI":71},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[74],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F22074","1979-2025",[78,79],"e89cebf4-fecf-4b74-8ab4-88fca891e4c2","8d793241-fb62-4735-9243-df74a7813046","SCOPUS__Q1",{"id":82,"indexDatabase":83,"url":97,"indexYears":18,"academicFieldIds":98,"indexDatabaseRanking":18},"61848c0f-d6c6-44fa-8e90-373ffb214976",{"id":84,"createTime":85,"updateTime":86,"relativeEntities":87,"label":88,"description":90,"key":93,"publicationTags":94,"standard":18},"a4921856-b128-4d9f-8f1f-e80813d3bbd4","2023-05-22T09:59:31.026+00:00","2025-11-21T10:07:52.153+00:00",[],{"EN":89,"VI":89},"ISI\u002FSCIE - Science Citation Index Expanded",{"VI":91,"EN":92},"Cơ sở dữ liệu SCIE","SCIE database","scie",[95,96],"SCIE","ISI","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=0172-8083",[99],"a88c02c1-1408-46e6-b021-2667e298d14d",{"impactFactor":19,"impactFactorByYear":101,"i10Index":19,"i10IndexLast5Year":19,"totalPublication":102,"totalPublicationByYear":103,"totalCitation":19,"totalCitationByYear":104,"totalCitationPerPublication":19,"totalCitationPerPublicationByYear":105,"hindexLast5Year":19,"hindex":19},{},1,{"2003":102},{},{},"JOURNAL",{"meta":108,"data":110},{"total":109},"3061",[111,253,344,435,514,617,706,822,899,1503],{"id":112,"createTime":113,"updateTime":114,"relativeEntities":115,"slug":116,"properties":117,"entityType":126,"verifyStatus":127,"verifyTime":114,"verifyNote":128,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":129,"fullTextUrl":18,"authors":130,"publicationType":216,"publisherRelationship":217,"citationCount":18,"citationInfo":18,"publishDate":250,"publishYear":251,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":252},"21139641-552a-40e1-93be-dc073b6baa9a","2024-02-18T21:07:03.389+00:00","2025-01-01T23:59:36.644+00:00",[],"Molecular-analysis-of-a-leu2-mutant-of-Candida-maltosa-demonstrates-the-presence-of-multiple-alleles",{"references":118,"abstract":120,"title":122,"doi":124},{"VOID":119},"Becher D, Wedler H, Schulze, Bode R, Kasüske A, Samsonova I (1991) Correlation of biochemical blocks and genetic lesions in leucine auxotrophic strains of the imperfect yeast Candida maltosa Mol Gen Genet 227:361–368\nBullock WD, Fernandez JM, Short NJM (1987) XL#1-Blue: a highly efficient plasmid transforming recA Escherichia coli strain with β-galactosidase selection. Biotechniques 5:376–378\nChang MC, Jung HK, Suzuki T, Takagi M, Yano K (1984) Ploidy of the asporogenous yeast Candida maltosa, isolation of its auxotrophic mutants and their cell fusion. J Gen Appl Microbiol 30: 489–497\nChu G, Vollrath D, Davis RW (1986) Separation of large DNA molecules by contour-clamped homogeneous electric fields. Science 234:1582–1585\nFeinberg AP, Vogelstein B (1983) A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132:6–13\nHorwitz JP, Chua J, Curby RJ, Tomson AJ, Daa Roge MA, Fisher BE, Mauricio J, Klundt I (1964) Substrates for cytochemical demonstration of enzyme activity. I. Some substituted 3-indolyl-D-glycopyranosides. J Med Chem 7:574–575\nKasüske A, Wedler H, Schulze S, Becher D (1992) Efficient electropulse transformation of intact Candida maltosa cells by different homologous vector plasmids. Yeast 8:691–697\nKawai S, Hikiji T, Murao S, Takagi M, Yano K (1991) Isolation and sequencing of a gene, C-ADE1, and its use for a host-vector system in Candida maltosa with two genetic markers. Agric Biol Chem 55:59–65\nKawamura M, Takagi M, Yano K (1983) Cloning of a LEU gene and an ARS site of Candida maltosa. Gene 24:157–162\nKunze G, Hecker M, Birnbaum D (1984) Molekularbiologische Charakterisierung der Genome von Candida spec.EH15, Lodderomyces elongisporus CBS 2605, Pichia guilliermondii SO809 und Pichia guilliermondii fp1–61. Zeitschrift Allg Mikrobiol 24: 33–40\nManiatis T, Fritsch EF, Sambrook J (1982) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York\nO'Connell MP (1984) Genetic transfer in prokaryotes: transformation, transduction, and conjugation. In: Pühler A, Timmis KN (eds) Advanced molecular genetics. Springer, Berlin Heidelberg New York, pp 2–5\nOliver SG et al. (1992) The complete DNA sequence of yeast chromosome III. Nature 357:38–46\nOhkuma M, Hikiji T, Tanimoto T, Schunck WH, Müller HG, Yano K, Takagi M (1991) Evidence that more than one gene encodes n-alkane-inducible cytochrome P-450 in Candida maltosa, found by two-step gene disruption. Agric Biol Chem 55:1757–1764\nSanger F, Nicklen S, Coulson AR (1977) DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74:5463–5467\nSasnauskas K, Jomantine R, Geneviciute E, Januska A, Lebedys J (1991) Molecular cloning of the Candida maltosa ADE1 gene. Gene 107:161–164\nSchunck WH, Kärgel E, Gross B, Wiedmann B, Mauersberger S, Köpke K, Kiebling U, Strauss M, Gaestel M, Müller HG (1989) Molecular cloning and characterization of the primary structure of the alkane hydroxylating cytochrome P-450 from the yeast Candida maltosa. Biochem Biophys Res Commun 161:843–850\nSouthern EM (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98:503–505\nTakagi M, Kobayashi N, Sugimoto M, Fuji T, Watari J, Yano K (1987) Nucleotide sequencing analysis of a LEU gene of Candida maltosa which complements the leuB mutation of Escherichia coli and the leu2 mutation of Saccharomyes cerevisiea. Curr Genet 11:451–457\nTanaka H, Takagi M, Yano K (1987) Separation of chromosomal DNA molecules of Candida maltosa on agarose gels using the OFAGE technique. Agric Biol Chem 51:3161–3163\nYannisch-Perron C, Vieira J, Messing J (1985) Improved M13 phage cloning vectors and host strains:nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33:103–119",{"EN":121},"Three different alleles of the β-isopropylmalate dehydrogenase gene were cloned and sequenced from a leucine auxotrophic mutant, G587, of Candida maltosa. The cloning of functionally-intact wild-type genes from this mutant strain suggests the presence of silent gene copies. An interallelic-divergence comparison has provided evidence for new regulatory mechanisms. Sequence data and karyotype analysis argue for a highly-aneuploid genome of C. maltosa. An interpretation for the spontaneous auxotrophy-prototrophy-auxotrophy sequence of mutations in C. maltosa is suggested.",{"EN":123},"Molecular analysis of a leu2 − mutant of Candida maltosa demonstrates the presence of multiple alleles",{"VOID":125},"10.1007\u002FBF00309549","PUBLICATION","VERIFIED","Auto Verify","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002FBF00309549",[131,148,166,178,191,203],{"id":132,"sortIndex":133,"researcher":18,"roles":134,"affiliations":136,"properties":145},"e8f4c9fb-e8f1-45c9-8b99-22183f721fe8",2,[135],"AUTHOR",[137],{"id":18,"sortIndex":19,"affiliation":138,"properties":18},{"id":139,"createTime":140,"updateTime":140,"relativeEntities":141,"slug":18,"properties":142,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"7e0d95ce-915a-410c-a547-0e2b9fa448d1","2024-02-18T21:07:03.415+00:00",[],{"title":143},{"VI":144},"Fachrichtung Biologie, Institut für Genetik und Biochemie, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany",{"title":146},{"VI":147},"Anette Kasüske",{"id":149,"sortIndex":150,"researcher":18,"roles":151,"affiliations":152,"properties":163},"fefef4ac-7c16-4866-b281-9a734082dc23",5,[135],[153],{"id":18,"sortIndex":19,"affiliation":154,"properties":18},{"id":155,"createTime":156,"updateTime":157,"relativeEntities":158,"slug":159,"properties":160,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"2d2c58af-8bd7-4040-baff-fcdd5b6570a1","2023-12-28T10:08:19.128+00:00","2024-09-03T01:31:41.801+00:00",[],"Department-of-Biochemistry-and-Applied-Molecular-Biology-UMIST-Manchester-UK",{"title":161},{"VI":162},"Department of Biochemistry and Applied Molecular Biology, UMIST, Manchester, UK",{"title":164},{"VI":165},"Stephen G. Oliver",{"id":167,"sortIndex":19,"researcher":18,"roles":168,"affiliations":169,"properties":175},"36d45f5f-a9a7-4cb9-972e-fb7be3762b3c",[135],[170],{"id":18,"sortIndex":19,"affiliation":171,"properties":18},{"id":139,"createTime":140,"updateTime":140,"relativeEntities":172,"slug":18,"properties":173,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":174},{"VI":144},{"title":176},{"VI":177},"Dietmar Becher",{"id":179,"sortIndex":180,"researcher":18,"roles":181,"affiliations":182,"properties":188},"f6517568-e05f-40ee-b3b5-5c85b5571f03",3,[135],[183],{"id":18,"sortIndex":19,"affiliation":184,"properties":18},{"id":139,"createTime":140,"updateTime":140,"relativeEntities":185,"slug":18,"properties":186,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":187},{"VI":144},{"title":189},{"VI":190},"Heiko Schulze",{"id":192,"sortIndex":102,"researcher":18,"roles":193,"affiliations":194,"properties":200},"191b13c2-cba5-4246-9f73-5d15fd87a381",[135],[195],{"id":18,"sortIndex":19,"affiliation":196,"properties":18},{"id":139,"createTime":140,"updateTime":140,"relativeEntities":197,"slug":18,"properties":198,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":199},{"VI":144},{"title":201},{"VI":202},"Steffen Schulze",{"id":204,"sortIndex":205,"researcher":18,"roles":206,"affiliations":207,"properties":213},"745ae961-391a-4403-a2c1-5216fd17ca35",4,[135],[208],{"id":18,"sortIndex":19,"affiliation":209,"properties":18},{"id":139,"createTime":140,"updateTime":140,"relativeEntities":210,"slug":18,"properties":211,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":212},{"VI":144},{"title":214},{"VI":215},"Ida A. Samsonova","ARTICLE",{"url":129,"publisher":218,"properties":245},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":219,"slug":10,"properties":220,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":223,"manageAffiliations":224,"indexDatabases":225,"url":18,"thumbnailPath":18,"statistic":240,"gsStatistic":18,"type":106,"analyzePriority":18},[],{"issn":221,"title":222},{"VOID":13},{"VOID":15},[],[],[226,233],{"id":82,"indexDatabase":227,"url":97,"indexYears":18,"academicFieldIds":232,"indexDatabaseRanking":18},{"id":84,"createTime":85,"updateTime":86,"relativeEntities":228,"label":229,"description":230,"key":93,"publicationTags":231,"standard":18},[],{"EN":89,"VI":89},{"VI":91,"EN":92},[95,96],[99],{"id":62,"indexDatabase":234,"url":75,"indexYears":76,"academicFieldIds":239,"indexDatabaseRanking":80},{"id":64,"createTime":65,"updateTime":66,"relativeEntities":235,"label":236,"description":237,"key":72,"publicationTags":238,"standard":18},[],{"EN":69,"VI":69},{"EN":69,"VI":71},[74],[78,79],{"impactFactor":19,"impactFactorByYear":241,"i10Index":19,"i10IndexLast5Year":19,"totalPublication":102,"totalPublicationByYear":242,"totalCitation":19,"totalCitationByYear":243,"totalCitationPerPublication":19,"totalCitationPerPublicationByYear":244,"hindexLast5Year":19,"hindex":19},{},{"2003":102},{},{},{"volume":246,"pages":248},{"VOID":247},"26",{"VOID":249},"208-216","1994-09-01",1994,false,{"id":254,"createTime":255,"updateTime":256,"relativeEntities":257,"slug":258,"properties":259,"entityType":126,"verifyStatus":127,"verifyTime":256,"verifyNote":128,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":268,"fullTextUrl":18,"authors":269,"publicationType":216,"publisherRelationship":309,"citationCount":18,"citationInfo":18,"publishDate":342,"publishYear":343,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":252},"ce51cf80-b464-4fd7-a47f-2deb1547d4b6","2023-12-28T19:29:52.911+00:00","2025-01-29T23:59:36.870+00:00",[],"Saccharomyces-cerevisiaeTSC11-AVO3-participates-in-regulating-cell-integrity-and-functionally-interacts-with-components-of-the-Tor2-complex",{"references":260,"abstract":262,"title":264,"doi":266},{"VOID":261},"Andrews PD, Stark MJ (2000) Type 1 protein phosphatase is required for maintenance of cell wall integrity, morphogenesis and cell cycle progression in Saccharomyces cerevisiae. J Cell Sci 113:507–520\nAudhya A, et al (2004) Genome-wide lethality screen identifies new PI4,5P(2) effectors that regulate the actin cytoskeleton. EMBO J 23:3747–3757\nBarbet N, et al (1996) TOR controls translation initiation and early G1 progression in yeast. Mol Biol Cell 7:25–42\nBeeler T, et al (1998) The Saccharomyces cerevisiaeTSC10\u002FYBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+ sensitive csg2Δ mutant. J Biol Chem 273:30688–30694\nBickle M, Delley PA, Schmidt A, Hall MN (1998) Cell wall integrity modulates RHO1 activity via the exchange factor ROM2. EMBO J 17:2235–2245\nChai B, Hsu JM, Du J, Laurent BC (2002) Yeast RSC function is required for organization of the cellular cytoskeleton via an alternative PKC1 pathway. Genetics 161:575–584\nChen M-Y, Long Y, Devreotes PN (1997) A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the twelve transmembrane domain adenylyl cyclase in Dictyostelium. Genes Dev 11:3218–3231\nChristianson TW, Skiorski RS, Dante M, Shero JH, Hieter P (1992) Multifunctional yeast high-copy-number shuttle vectors. Gene 110:119–122\nCostigan C, Gehrung S, Snyder M (1992) A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth. Mol Cell Biol 12:1162–1178\nFingar DC, Blenis J (2004) Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23:3151–3171\nFiron A, Lesage G, Bussey H (2004) Integrative studies put cell wall synthesis on the yeast functional map. Curr Opin Microbiol 7:617–623\nFlynn P, Mellor H, Palmer R, Panayotou G, Parker PJ (1998) Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif. J Biol Chem 273:2698–2705\nGarcia R, et al (2004) The global transcriptional response to transient cell wall damage in Saccharomyces cerevisiae and its regulation by the cell integrity signaling pathway. J Biol Chem 279:15183–15195\nGeitz D, St Jean A, Woods RA, Schiestl RH (1992) Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res 20:1425\nGustin MC, Albertyn J, Alexander M, Davenport K (1998) MAP kinase pathways in the yeast Saccharomyces cerevisiae. Microbiol Mol Biol Rev 62:1264–1300\nHara K, et al (2002) Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110:177–189\nHeinisch JJ, Lorberg A, Schmitz HP, Jacoby JJ (1999) The protein kinase C-mediated MAP kinase pathway involved in the maintenance of cellular integrity in Saccharomyces cerevisiae. Mol Microbiol 32:671–680\nHeitman J, Movva NR, Hall MN (1991) Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253:905–909\nHelliwell SB, et al (1994) TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol Biol Cell 5:105–118\nHelliwell SB, Howald I, Barbet N, Hall MN (1998a) TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae. Genetics 148:99–112\nHelliwell SB, Schmidt A, Ohya Y, Hall MN (1998b) The Rho1 effector, Pkc1, but not Bni1, mediates signaling from Tor2 to the actin cytoskeleton. Curr Biol 8:1211–1214\nHilti N, Baumann D, Schweingruber A-M, Bigler P, Schweingruber ME (1999) Gene ste20 controls amiloride sensitivity and fertility in Schizosaccharomyces pombe. Curr Genet 35:585–592\nIgual JC, Johnson AL, Johnston LH (1996) Coordinated regulation of gene expression by the cell cycle transcription factor Swi4 and the protein kinase C MAP kinase pathway for yeast cell integrity. EMBO J 15:5001–5013\nJacinto E, et al (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6:1122–1128\nKaeberlein M, Guarente L (2002) Saccharomyces cerevisiaeMPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 160:83–95\nKamada Y, et al (1996) Activation of yeast protein kinase C by Rho1 GTPase. J Biol Chem 271:9193–9196\nKarpova TS, Lepetit MM, Cooper JA (1993) Mutations that enhance the cap2 null mutant phenotype in Saccharomyces cerevisiae affect the actin cytoskeleton, morphogenesis and pattern of growth. Genetics 135:693–709\nKetela T, Green R, Bussey H (1999) Saccharomyces cerevisiae Mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway. J Bacteriol 181:3330–3340\nKim DH, et al (2002) mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110:163–175\nKim DH, et al (2003) GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 11:895–904\nKunz J, et al (1993) Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell 73:585–596\nLagorce A, et al (2003) Genome-wide analysis of the response to cell wall mutations in the yeast Saccharomyces cerevisiae. J Biol Chem 278:20345–20357\nLin J-J, Zakian VA (1996) The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo. Proc Natl Acad Sci USA 93:13760–13765\nLoewith R, et al (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10:457–468\nLorenz MC, et al (1995) Gene disruption with PCR products in Saccharomyces cerevisiae. Gene 158:113–117\nMarchler-Bauer A, et al (2005) CDD: a conserved domain database for protein classification. Nucleic Acids Res 33:D192–D196\nMarchler-Bauer A, Bryant SH (2004) CD-Search: protein domain annotations on the fly. Nucleic Acids Res 32:W327–W331\nMartin H, et al (1996) Molecular and functional characterization of a mutant allele of the mitogen-activated protein-kinase gene SLT2 (MPK1) rescued from yeast autolytic mutants. Curr Genet 29:516–522\nMartin H, Rodriguez-Pachon JM, Ruiz C, Nombela C, Molina M (2000) Regulatory mechanisms for modulation of signaling through the cell integrity Slt2-mediated pathway in Saccharomyces cerevisiae. J Biol Chem 275:1511–1519\nMazur P, Baginsky W (1996) In vitro activity of 1,3-beta-d-glucan synthase requires the GTP-binding protein Rho1. J Biol Chem 271:14604–14609\nMuhlrad D, Hunter R, Parker R (1992) A rapid method for localized mutagenesis of yeast genes. Yeast 8:79–82\nMumberg D, Muller R, Funk M (1994) Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expression. Nucleic Acids Res 22:5767–5768\nNickas ME, Yaffe MP (1996) BRO1, a novel gene that interacts with components of the Pkc1p-mitogen-activated protein kinase pathway in Saccharomyces cerevisiae. Mol Cell Biol 16:2585–2593\nNonaka H, et al (1995) A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae . EMBO J 14:5931–5938\nNotredame C, Higgins D, Heringa J (2000) T-Coffee: a novel method for multiple sequence alignments. J Mol Biol 302:205–217\nPhilip B, Levin DE (2001) Wsc1 and Mid2 are cell surface sensors for cell wall integrity signaling that act through Rom2, a guanine nucleotide exchange factor for Rho1. Mol Cell Biol 21:271–280\nRajavel M, Philip B, Buehrer BM, Errede B, Levin DE (1999) Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Mol Cell Biol 19:3969–3976\nRaught B, Gingras A-C, Sonenberg N (2001) The target of rapamycin (TOR) proteins. Proc Natl Acad Sci USA 98:7037–7044\nSambrook J, Russell DW (2001) Molecular cloning: a laboratory manual, 3rd edn. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.\nSarbassov DD et al (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 14:1296–1302\nSchmelzle T, Hall MN (2000) TOR, a central controller of cell growth. Cell 103:253-262\nSchmidt A, Kunz J, Hall MN (1996) TOR2 is required for organization of the actin cytoskeleton in yeast. Proc Natl Acad Sci USA 93:13780–13785\nSchmidt A, Bickle M, Beck T, Hall MN (1997) The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell 88:531–542\nShamji AF, Kuruvilla FG, Schreiber SL (2000) Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins. Curr Biol 10:1574–1581\nSikorski RS, Boeke JD (1991) In vitro mutagenesis and plasmid shuffling: from cloned genes to mutant yeast. Methods Enzymol 194:302–318\nSikorski RS, Hieter P (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19–27\nSmith V, Chou KN, Lashkare D, Botstein D, Brown PO (1996) Functional analysis of the genes of yeast chromosome V by genetic footprinting. Science 274:2069–2074\nTorres J, Di Como CJ, Herrero E, de la Torre-Ruiz MA (2002) Regulation of the cell integrity pathway by rapamycin-sensitive TOR function in budding yeast. J Biol Chem 277:43495–43504\nUetz P, et al (2000) A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403:623–627\nVerna J, Lodder A, Lee K, Vagts A, Ballester R (1997) A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 94:13804–13809\nWedaman KP, et al (2003) Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol Biol Cell 14:1204–1220\nYu JW, et al (2004) Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains. Mol Cell 13:677–688\nZheng XF, Florentino D, Chen J, Crabtree GR, Schreiber SL (1995) TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell 82:121–130",{"EN":263},"Saccharomyces cerevisiae TSC11\u002FAVO3 is an essential gene encoding one component of TORC2, a multi-protein complex of yeast Tor2p that also contains Lst8p, Avo1p, and Avo2p. Despite the proven physical association among TORC2 components, little is known about the functional linkage or cellular pathways these proteins act in. Here, we present genetic data linking the function of TSC11 to the regulation of cell integrity. Mutants carrying temperature-sensitive (ts) alleles in different regions of TSC11 displayed cell wall defects, evidenced by characteristic osmotic stabilizer-remediable cell lysis, susceptibility to trypan blue staining, and sensitivity to cell wall-digesting enzymes. Dosage suppression analysis identified different groups of genes in rescuing phenotypes of different tsc11\n                  ts\n                 mutants. AVO1 suppressed one class of mutants, whereas active PKC1, AVO2, and SLM1 partially rescued another. Our findings demonstrate functional connections among TORC2 components and we speculate that Tsc11p exerts its function via a Pkc1p-independent mechanism mediated through Avo1p, and a Pkc1p-dependent mechanism mediated through Avo2p and Slm1p.",{"EN":265},"Saccharomyces cerevisiaeTSC11\u002FAVO3 participates in regulating cell integrity and functionally interacts with components of the Tor2 complex",{"VOID":267},"10.1007\u002Fs00294-005-0570-8","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00294-005-0570-8",[270,285,297],{"id":271,"sortIndex":102,"researcher":18,"roles":272,"affiliations":273,"properties":282},"65dba168-74bf-47de-9d78-fa789af3e77a",[135],[274],{"id":18,"sortIndex":19,"affiliation":275,"properties":18},{"id":276,"createTime":277,"updateTime":277,"relativeEntities":278,"slug":18,"properties":279,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"b9d65730-b4b6-4517-827d-0b8f08afb56a","2023-12-28T19:29:52.921+00:00",[],{"title":280},{"VI":281},"Institute of Biochemistry, School of Life Sciences and Department of Biochemistry, School of Medicine, National Yang-Ming University, Shih-Pai, Taiwan",{"title":283},{"VI":284},"Yu-Shih Shiau",{"id":286,"sortIndex":19,"researcher":18,"roles":287,"affiliations":288,"properties":294},"be38c5b5-f02d-42fc-bd99-1aec1b11867a",[135],[289],{"id":18,"sortIndex":19,"affiliation":290,"properties":18},{"id":276,"createTime":277,"updateTime":277,"relativeEntities":291,"slug":18,"properties":292,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":293},{"VI":281},{"title":295},{"VI":296},"Hsiang-Ling Ho",{"id":298,"sortIndex":133,"researcher":18,"roles":299,"affiliations":300,"properties":306},"1d391fb4-8ac9-430f-86f6-5029fe2f27b9",[135],[301],{"id":18,"sortIndex":19,"affiliation":302,"properties":18},{"id":276,"createTime":277,"updateTime":277,"relativeEntities":303,"slug":18,"properties":304,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":305},{"VI":281},{"title":307},{"VI":308},"Mei-Yu Chen",{"url":268,"publisher":310,"properties":337},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":311,"slug":10,"properties":312,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":315,"manageAffiliations":316,"indexDatabases":317,"url":18,"thumbnailPath":18,"statistic":332,"gsStatistic":18,"type":106,"analyzePriority":18},[],{"issn":313,"title":314},{"VOID":13},{"VOID":15},[],[],[318,325],{"id":82,"indexDatabase":319,"url":97,"indexYears":18,"academicFieldIds":324,"indexDatabaseRanking":18},{"id":84,"createTime":85,"updateTime":86,"relativeEntities":320,"label":321,"description":322,"key":93,"publicationTags":323,"standard":18},[],{"EN":89,"VI":89},{"VI":91,"EN":92},[95,96],[99],{"id":62,"indexDatabase":326,"url":75,"indexYears":76,"academicFieldIds":331,"indexDatabaseRanking":80},{"id":64,"createTime":65,"updateTime":66,"relativeEntities":327,"label":328,"description":329,"key":72,"publicationTags":330,"standard":18},[],{"EN":69,"VI":69},{"EN":69,"VI":71},[74],[78,79],{"impactFactor":19,"impactFactorByYear":333,"i10Index":19,"i10IndexLast5Year":19,"totalPublication":102,"totalPublicationByYear":334,"totalCitation":19,"totalCitationByYear":335,"totalCitationPerPublication":19,"totalCitationPerPublicationByYear":336,"hindexLast5Year":19,"hindex":19},{},{"2003":102},{},{},{"volume":338,"pages":340},{"VOID":339},"47",{"VOID":341},"273-288","2005-04-05",2005,{"id":345,"createTime":346,"updateTime":347,"relativeEntities":348,"slug":349,"properties":350,"entityType":126,"verifyStatus":127,"verifyTime":347,"verifyNote":128,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":359,"fullTextUrl":18,"authors":360,"publicationType":216,"publisherRelationship":400,"citationCount":18,"citationInfo":18,"publishDate":433,"publishYear":434,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":252},"9989f897-d6f7-43fd-8837-37ca2c63e934","2023-12-29T23:38:24.338+00:00","2024-12-13T23:59:26.002+00:00",[],"Localization-of-chloroplast-ribosomal-protein-genes-on-Spirodela-oligorhiza-chloroplast-DNA",{"references":351,"abstract":353,"title":355,"doi":357},{"VOID":352},"Bartsch M (1985) J Biol Chem 260:237–241\nBoyton JE, Gillham NW, Lambowitz (1981) In: Chambliss G, Graven GR, Davies J, Davies K, Kahan L, Nomura M (eds) Ribosomes: structure, function and genetics. University Park Press, Baltimore, pp 903–950\nBünemann H, Westhoff P, Herrmann RG (1982) Nucleic Acids Res 10:7163–7180\nCeretti DP, Dean D, Davis GR, Bedwell DM, Nomura M (1983) Nucleic Acids Res 11:2599–2616\nDe Heij JT, Lustig H, Moeskops DIM, Bovenberg WA, Bisanz C, Groot GSP (1983) Curr Genet 7:1–6\nDorne AM, Lescure AM, Mache R (1984) Plant Mol Biol 3:83–90\nEneas-Filho J, Hartley MR, Mache R (1981) Mol Gen Genet 184:484–488\nFluhr R, Edelman M (1981) Nucleic Acids Res 9:6841–6853\nFreyssinet G (1978) Exp Cell Res 115:207–219\nGroot GSP (1985) In: Van Vloten-Doting L, Groot GSP, Hall T (eds) Molecular form and function of the plant genome. Plenum Press, New York, pp 175–181\nHallick RB, Bottomley W (1983) Plant Mol Biol Rep 1: 38–43\nHerrmann RG, Possingham JV (1980) In: Reinert J (ed). Results and problems in cell differentiation, vol 10. Springer, New York Berlin Heidelberg, pp 45–96\nHerrmann RG, Westhoff P, Alt J, Tittgen J, Nelson N (1985) In: Van Vloten-Doting L, Groot GSP, Hall T (eds). Molecular form and function of the plant genome. Plenum Press, New York, pp 233–256\nKössel H, Natt E, Strittmatter G, Fritzsche E, Gozdzicka-Jozefiak A, Przybyl D (1985) In: Van Vloten-Doting L, Groot GSP, Hall T (eds). Molecular form and function of the plant genome. Plenum Press, New York, pp 183–198\nKung SD, Zhu YS, Shen GF (1982) Theor Appl Genet 61:73–79\nMontandon P, Stutz E (1984) Nucleic Acids Res 12:2851–2859\nNomura M (1984a) Sci Am 250:72–84\nNomura M (1984b) Annu Rev Biochem 53:75–117\nOkyama K, Yamano Y, Fukuzawa H, Komano T, Yamagishi H, Fujimoto S, Sugiura M (1983) Mol Gen Genet 189:1–9\nPalmer JD (1982) Nucleic Acids Res 10:1593–1605\nPalmer JD, Thompson WF (1982) Cell 29:537–550\nPalmer JD, Singh GP, Pillay DTN (1983) Mol Gen Genet 190: 13–19\nPosno M, Van Noort M, Débise R, Groot GSP (1984) Curr Genet 8:147–154\nPosno M, Torenvliet DJ, Lustig H, Van Noort M, Groot GSP (1985) Curr Genet 9:211–219\nPosno M, Van Vliet A, Groot GSP (1986) Nucleic Acids Res 14: 3181–3195\nSchmidt RJ, Richardson CB, Gillham NW, Boyton JE (1983) J Cell Biol 96:1451–1463\nSchmidt RJ, Myers AM, Gillham NW, Boyton JE (1984) Mol Biol Evol 1: 317–334\nSubramanian AR, Steinmetz A, Bogorad L (1983) Nucleic Acids Res 11:5277–5286\nSugita M, Sugiura M (1983) Nucleic Acids Res 11:1913–1918\nUmesono K, Inakuchi H, Okyama K, Ozeki H (1984) Nucleic Acids Res 12:9551–9565\nVan Ee JH, Man in `t Veld WA, Planta RJ (1980) Plant Physiol 66:572–575\nVan Ee JH, Vos YJ, Bohnert HJ, Planta RJ (1982) Plant Mol Biol 2:117–131\nWesthoff P, Nelson N, Bünemann H, Herrmann RG (1981) Curr Genet 4:109–120\nWhitfeld PR, Bottomley W (1983) Annu Rev Plant Physiol 34: 279–301\nZurawski G, Zurawski SM (1985) Nucleic Acids Res 13:4521–4526\nZurawski G, Bottomley W, Whitfeld PR (1984) Nucleic Acids Res 12:6547–6558",{"EN":354},"Three chloroplast ribosomal protein genes have been located on Spirodela chloroplast DNA. (1) rps14 was physically mapped at the central region of the large single copy region by heterologous hybridization with the corresponding gene of Marchantia chloroplast DNA. (2) Chloroplast ribosomal protein C-S23 was detected by immunoprecipitation with a polyspecific antiserum against 30S chloroplast ribosomal proteins among the in vitro translation products of mRNAs selected by Spirodela Pstl-D chloroplast DNA fragment. (3) We have previously reported that Spirodela BamHI-G chloroplast DNA fragment encodes a 14–15 kD 50S chloroplast ribosomal protein (Posno et al. 1985 Curr Genet 9 : 211–219). Here we show that the homologous Spinacia chloroplast DNA fragment Sa1I-9 additionally directs the synthesis of another 50S chloroplast ribosomal protein in a DNA dependent E. coli cellfree system. This was confirmed by molecular weight determination, immunoprecipitation and competition immunoprecipitation experiments. mRNA selection experiments revealed that this additional chloroplast ribosomal protein gene is present on Spirodela chloroplast DNA as well, but is not expressed in the E. coli cellfree system. The identity of this 50S chloroplast ribosomal protein could not be established unambiguously, since two-dimensional gel analysis revealed that this protein comigrated, depending on the experiment, with C-L11 (26 kD) or with C-L24 (17 kD).",{"EN":356},"Localization of chloroplast ribosomal protein genes on Spirodela oligorhiza chloroplast DNA",{"VOID":358},"10.1007\u002FBF00398290","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002FBF00398290",[361,376,388],{"id":362,"sortIndex":102,"researcher":18,"roles":363,"affiliations":364,"properties":373},"7be13282-c8d7-4c7a-86db-9f2312092418",[135],[365],{"id":18,"sortIndex":19,"affiliation":366,"properties":18},{"id":367,"createTime":368,"updateTime":368,"relativeEntities":369,"slug":18,"properties":370,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"33ebf40b-54b3-4ea1-91f2-ac9438f5cc58","2023-12-29T23:38:24.391+00:00",[],{"title":371},{"VI":372},"Biochemical Laboratory, Free University, Amsterdam, The Netherlands",{"title":374},{"VI":375},"Anja van Vliet",{"id":377,"sortIndex":133,"researcher":18,"roles":378,"affiliations":379,"properties":385},"7c517559-e83f-4916-bd07-347b6b742935",[135],[380],{"id":18,"sortIndex":19,"affiliation":381,"properties":18},{"id":367,"createTime":368,"updateTime":368,"relativeEntities":382,"slug":18,"properties":383,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":384},{"VI":372},{"title":386},{"VI":387},"Gert S. P. Groot",{"id":389,"sortIndex":19,"researcher":18,"roles":390,"affiliations":391,"properties":397},"9d00e2ef-586e-4bd0-9d1b-9f09ee186ee3",[135],[392],{"id":18,"sortIndex":19,"affiliation":393,"properties":18},{"id":367,"createTime":368,"updateTime":368,"relativeEntities":394,"slug":18,"properties":395,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":396},{"VI":372},{"title":398},{"VI":399},"Mark Posno",{"url":359,"publisher":401,"properties":428},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":402,"slug":10,"properties":403,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":406,"manageAffiliations":407,"indexDatabases":408,"url":18,"thumbnailPath":18,"statistic":423,"gsStatistic":18,"type":106,"analyzePriority":18},[],{"issn":404,"title":405},{"VOID":13},{"VOID":15},[],[],[409,416],{"id":82,"indexDatabase":410,"url":97,"indexYears":18,"academicFieldIds":415,"indexDatabaseRanking":18},{"id":84,"createTime":85,"updateTime":86,"relativeEntities":411,"label":412,"description":413,"key":93,"publicationTags":414,"standard":18},[],{"EN":89,"VI":89},{"VI":91,"EN":92},[95,96],[99],{"id":62,"indexDatabase":417,"url":75,"indexYears":76,"academicFieldIds":422,"indexDatabaseRanking":80},{"id":64,"createTime":65,"updateTime":66,"relativeEntities":418,"label":419,"description":420,"key":72,"publicationTags":421,"standard":18},[],{"EN":69,"VI":69},{"EN":69,"VI":71},[74],[78,79],{"impactFactor":19,"impactFactorByYear":424,"i10Index":19,"i10IndexLast5Year":19,"totalPublication":102,"totalPublicationByYear":425,"totalCitation":19,"totalCitationByYear":426,"totalCitationPerPublication":19,"totalCitationPerPublicationByYear":427,"hindexLast5Year":19,"hindex":19},{},{"2003":102},{},{},{"volume":429,"pages":431},{"VOID":430},"10",{"VOID":432},"923-930","1986-08-01",1986,{"id":436,"createTime":437,"updateTime":438,"relativeEntities":439,"slug":440,"properties":441,"entityType":126,"verifyStatus":127,"verifyTime":438,"verifyNote":128,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":450,"fullTextUrl":18,"authors":451,"publicationType":216,"publisherRelationship":479,"citationCount":18,"citationInfo":18,"publishDate":512,"publishYear":513,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":252},"f9d9c576-f094-424a-974d-278a5971b4d3","2024-02-18T15:45:31.484+00:00","2025-01-07T23:59:12.370+00:00",[],"Molecular-analysis-of-a-novelSchizosaccharomyces-pombe-gene-containing-two-RNP-consensus-sequence-RNA-binding-domains",{"references":442,"abstract":444,"title":446,"doi":448},{"VOID":443},"Adam SA, Nakagawa TY, Swanson MS, Woodruff T, Dreyfuss G (1986) mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence. Mol Cell Biol 6:2932–2943\nAltschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215:403–410\nApolinaro E, Nocero M, Jin M, Hoffman CS (1994) Cloning and manipulation of theSchizosaccharomyces pombe his7 + gene as a new selectable marker for molecular genetic studies. Curr Genet 24:491–495\nBandziulis RJ, Swanson MS, Dreyfuss G (1989) RNA-binding proteins as developmental regulators. Genes Dev 32:431–437\nBentley RC, Keene JD (1991) Recognition of U1 and U2 small nuclear RNAs can be altered by a 5-amino-acid segment in the U2 small nuclear ribonucleoprotein particle (snRNP) B″ protein and through interactions with the U2 snRNP-A′ protein. Mol Cell Biol 11:1829–1839\nBirney E, Kumar S, Krainer AR (1993) Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. Nucleic Acids Res 21:5803–5816\nBresch C, Muller G, Egel R (1968) Genes involved in meiosis and sporulation of a yeast. Mol Gen Genet 102:301–306\nBurd CG, Dreyfuss G (1994) Conserved structures and diversity of functions of RNA-binding proteins. Science 265:615–621\nBurd CG, Matunis EL, Dreyfuss G (1991) The multiple RNA-binding domains of the mRNA poly(A)-binding protein have different RNA-binding activities. Mol Cell Biol 11:3419–3424\nChampion-Arnaud P, Reed R (1994) The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site. Genes Dev 8:1974–1983\nCobianchi R, SenGupta DN, Zmudzka BZ, Wilson SH (1986) Structure of rodent helix-destabilizing protein revealed by cDNA cloning. J Biol Chem 261:3536–3543\nCusick ME (1994) RNP1, a new ribonucleoprotein gene of the yeastSaccharomyces cerevisiae. Nucleic Acids Res 22:869–877\nDreyfuss G, Matunis MJ, Pinol-Roma S, Burd CG (1993) hnRNP proteins and the biogenesis of mRNA. Annu Rev Biochem 62:289–321\nFikes JD, Becker DM, Winston F (1990) Striking conservation of TFIID inSchizosaccharomyces pombe andSaccharomyces cerevisiae. Nature 346:291–294\nHiggins DG, Sharp PM (1989) Fast and sensitive multiple sequence alignments on a microcomputer. CABIOS 5:151–153\nHoffman DW, Query CC, Golden BL, White SW, Keene JD (1991) RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal protein. Proc Natl Acad Sci USA 88:2495–2499\nKim Y-J, Baker BS (1993) Isolation of RRM-type RNA-binding protein genes and the analysis of their relatedness by using a numerical approach. Mol Cell Biol 13:174–183\nLiao X, Brennwald P, Wise JA (1989) Genetic analysis ofSchizosaccharomyces pombe 7SL RNA: a structural motif that includes a conserved tetranucleotide loop is important for function. Proc Natl Acad Sci USA 86:4137–4141\nNagai K, Oubridge C, Jessen TH, Li J, Evans PR (1990) Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. Nature 348:515–520\nPearson WR, Lipman DJ (1988) Improved tools for biological sequence comparison. Proc Natl Acad Sci USA 85:2444–2448\nPorter G, Brennwald P, Wise JA (1990) U1 small nuclear RNA fromSchizosaccharomyces pombe has unique and conserved features and is encoded by an essential single-copy gene. Mol Cell Biol 10:2874–2881\nPotashkin J, Naik K, Wentz-Hunter K (1993) U2AF homolog required for splicing in vivo. Science 262:573–575\nQuery CC, Bentley RC, Keene JD (1989) A common RNA recognition motif identified within a defined U1 RNA-binding domain of the 70 U1 snRNP protein. Cell 57:89–101\nRiva S, Morandi C, Tsoulfas P, Pandolfo M, Biamonti G, Merrill B, Williams KR, Multhaup G, Beyreuther K, Werr H, Henrich B, Schafer KP (1986) Mammalian single-stranded DNA-binding protein UPI is derived from the ImRNP core protein A1. EMBO J 5:2267–2273\nSachs AB, Bond WM, Kornberg RD (1986) A single gene from yeast for both nuclear and cytoplasmic polyadenylate-binding protein: domain structure and expression. Cell 45:827–835\nSaitou N, Nei M (1987) The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 4:406–425\nSambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York\nScherly D, Boelens W, Dathan NA, van Venrooij WJ, Mattaj IW (1990) Major determinants of the specificity of interaction between small nuclear ribonucleoproteins U1A and U2B″ and their cognate RNAs. Nature 345:502–506\nSelinger DA, Porter GL, Brennwald PJ, Wise JA (1992) The two similarly expressed genes encoding U3 snRNA inSchizosaccharomyces pombe lack introns. Mol Biol Evol 9:297–308\nSwanson MS, Nakagawa TY, LeVan K, Dreyfuss G (1987) Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA and pre-rRNA-binding proteins. Mol Cell Biol 7:1731–1739\nThompson JD, Higgins DG, Gibson TJ (1994) CLUSTALW: improving the sensitivity of progressive multiple sequence alignments through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22:4673–4680.\nToda T, Shimanuki M, Yanagida M (1991) Fission-yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1\u002FMAP2 and budding-yeast FUS3 and KSSI kinases. Genes Dev 5:60–73\nToyama R, Goldstein DJ, Schlegel R, Dhar R (1992) A genomic sequence of theSchizosaccharomyces pombe 16-kDa vacuolar H + -ATPase. Yeast 7:989–991\nWatanabe Y, Yamamoto M (1994)S. pombe mei2 + encodes an RNA-binding protein essential for premeiotic DNA synthesis and meiosis I, which cooperates with a novel RNA species meiRNA. Cell 78:487–498\nWittekind M, Gorlach M, Friedrichs M, Dreyfuss G, Mueller L (1992) 1H, 13C, and 15N NMR assignments and global folding pattern of the RNA-binding domain of the human hnRNP C proteins. Biochemistry 31:6254–6265",{"EN":445},"Proteins containing RNP consensus-sequence RNA-binding domains (CS-RBDs) play diverse roles in many aspects of RNA metabolism. Using a PCR strategy, we cloned portions of six newSchizosaccharomyces pombe genes encoding RBD proteins, including a putative homolog of the mammalian splicing factor SAP49. The genomic locus corresponding to a second PCR product, designatedrnp24, was cloned and characterized in detail. Sequence analysis revealed that the Rnp24 protein is highly charged and contains a second RBD with an unusually long Loop-3 sequence. Strains containing a disrupted copy of thernp24 gene display neither loss of viability nor any discernible growth defects under a variety of conditions, suggesting that the function of Rnp24p overlaps with that of another fission yeast protein. Although database searches did not identify proteins that share extensive amino-acid identity with Rnp24p, phylogenetic analysis suggests that its closest relatives are metazoan hnRNP proteins. The lack of an observable phenotype inS. pombe cells lacking Rnp24p is consistent with this classification, since hnRNP proteins in higher cells include several distinct subfamilies with similar sequences and RNA-binding specifities.",{"EN":447},"Molecular analysis of a novelSchizosaccharomyces pombe gene containing two RNP consensus-sequence RNA-binding domains",{"VOID":449},"10.1007\u002FBF02208611","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002FBF02208611",[452,467],{"id":453,"sortIndex":102,"researcher":18,"roles":454,"affiliations":455,"properties":464},"63906049-0d5f-461a-a6b0-6aa34c44e161",[135],[456],{"id":18,"sortIndex":19,"affiliation":457,"properties":18},{"id":458,"createTime":459,"updateTime":459,"relativeEntities":460,"slug":18,"properties":461,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"c776d913-3688-40d8-8178-511983d00ec0","2023-12-26T09:12:03.903+00:00",[],{"title":462},{"VI":463},"Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland, USA",{"title":465},{"VI":466},"Jo Ann Wise",{"id":468,"sortIndex":19,"researcher":18,"roles":469,"affiliations":470,"properties":476},"c70773d0-4f90-4bf2-bf46-b7f4e26a1aca",[135],[471],{"id":18,"sortIndex":19,"affiliation":472,"properties":18},{"id":458,"createTime":459,"updateTime":459,"relativeEntities":473,"slug":18,"properties":474,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":475},{"VI":463},{"title":477},{"VI":478},"Roger W. VanHoy",{"url":450,"publisher":480,"properties":507},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":481,"slug":10,"properties":482,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":485,"manageAffiliations":486,"indexDatabases":487,"url":18,"thumbnailPath":18,"statistic":502,"gsStatistic":18,"type":106,"analyzePriority":18},[],{"issn":483,"title":484},{"VOID":13},{"VOID":15},[],[],[488,495],{"id":82,"indexDatabase":489,"url":97,"indexYears":18,"academicFieldIds":494,"indexDatabaseRanking":18},{"id":84,"createTime":85,"updateTime":86,"relativeEntities":490,"label":491,"description":492,"key":93,"publicationTags":493,"standard":18},[],{"EN":89,"VI":89},{"VI":91,"EN":92},[95,96],[99],{"id":62,"indexDatabase":496,"url":75,"indexYears":76,"academicFieldIds":501,"indexDatabaseRanking":80},{"id":64,"createTime":65,"updateTime":66,"relativeEntities":497,"label":498,"description":499,"key":72,"publicationTags":500,"standard":18},[],{"EN":69,"VI":69},{"EN":69,"VI":71},[74],[78,79],{"impactFactor":19,"impactFactorByYear":503,"i10Index":19,"i10IndexLast5Year":19,"totalPublication":102,"totalPublicationByYear":504,"totalCitation":19,"totalCitationByYear":505,"totalCitationPerPublication":19,"totalCitationPerPublicationByYear":506,"hindexLast5Year":19,"hindex":19},{},{"2003":102},{},{},{"volume":508,"pages":510},{"VOID":509},"29",{"VOID":511},"307-315","1996-03-01",1996,{"id":515,"createTime":516,"updateTime":517,"relativeEntities":518,"slug":519,"properties":520,"entityType":126,"verifyStatus":127,"verifyTime":517,"verifyNote":128,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":102,"primaryUrl":529,"fullTextUrl":18,"authors":530,"publicationType":216,"publisherRelationship":584,"citationCount":18,"citationInfo":18,"publishDate":616,"publishYear":434,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":252},"b75fa67b-d818-4402-8c82-50c4a37d0d4e","2023-12-04T11:58:49.716+00:00","2024-12-20T23:58:38.293+00:00",[],"Cloning-and-characterisation-of-the-ribosomal-RNA-genes-of-the-dimorphic-yeast-Yarrowia-lipolytica",{"references":521,"abstract":523,"title":525,"doi":527},{"VOID":522},"Barnitz J, Cramer JH, Rownd RH, Cooley L, Soll D (1982) FEBS Lett 143:129–132\nBayev AA, Georgiev OI, Hadjiolov AA, Kermechiev MB, Nicholaev N, Skryabin KG, Zakharyev VM (1981) Nucleic Acids Res 8:4919–4962\nBell GI, DeGennaro LJ, Gelfand DH, Bishop RJ, Valenzuela P, Rutter WJ (1977) J Biol Chem 252:8118–8125\nBollen AP (1982) Organization of fungal ribosomal RNA genes. In: Busch H (ed) The cell nucleus, vol 10. Academic Press, New York London, pp 67–175\nBorsuk PA, Nagiec MM, Stepien PP, Bartnik E (1982) Gene 17:147–152\nCihlar RL, Sypherd PS (1980) Nucleic Acids Res 8:793–804\nDenhardt DT (1966) Biochem Biophys Res Commun 23:641–646\nFree SJ, Rice PW, Metzenberger RL (1979) J Bacteriol 137:1219–1226\nGaillardin CM, Charoey V, Heslot H (1973) Arch Microbiol 92:69–83\nGrunstein M, Hogness DS (1975) Proc Natl Acad Sci USA 72:3961–3965\nLockington RA, Taylor GD, Winther M, Scazzocchio C, Davies RW (1982) Gene 20:135–137\nMaizels N (1976) Cell 9:431–438\nOrgryzdiak DM, Mortimer RK (1977) Genetics 87:621–632\nPetes TD, Hereford LM, Skryabin KG (1978) J Bacteriol 134:295–305\nRigby PWJ, Dieckmann M, Rhodes C, Berg P (1977) J Mol Biol 113:237–251\nRozek CE, Timberlake WE (1979) Nucleic Acids Res 8:1567–1578\nSouthern EM (1975) J Mol Biol 98:503–517\nSpecht CA, DiRusso CC, Novotny CP, Ullrich RC (1982) Anal Biochem 119:158–163\nTabata S (1980) Eur J Biochem 110:107–114\nVan Heerikhuizen H, Ykema A, Klootwijk J, Gaillardin C, Ballas C, Fournier P (1986) Gene (in press)\nVerbeet PPL, Klootwijk J, Van Heerikhuizen H, Fontijn R, Vreugdenhil E, Planta R (1983) Gene 23:53–63\nWilliamson DH, Fennell DJ (1975) Methods Cell Biol 12:335–351",{"EN":524},"The ribosomal RNA genes of Yarrowia lipolytica have been identified, both in restriction digests of total genomic DNA and in a pBR322 gene bank, by hybridisation with cloned Saccharomyces cerevisiae rDNA. The Y. lipolytica rDNA repeat unit is 8.9 kb in size and contains the genes for the 25S and 18S, but not the 5S, rRNA species. The number of copies of these repeat units is approx. 50 per haploid genome. Several clones were found which did not conform to the standard restriction map due to differences outside the coding region. It appears that there is either heterogeneity of the spacer sequence within a strain or that the Y. lipolytica rDNA genes may be present as a number of separate clusters within this yeast's genome.",{"EN":526},"Cloning and characterisation of the ribosomal RNA genes of the dimorphic yeast, Yarrowia lipolytica",{"VOID":528},"10.1007\u002FBF00419872","http:\u002F\u002Flink.springer.com\u002F10.1007\u002FBF00419872",[531,546,561,573],{"id":532,"sortIndex":19,"researcher":18,"roles":533,"affiliations":534,"properties":543},"7f572b36-792b-4ab6-8525-256dffe8ef83",[135],[535],{"id":18,"sortIndex":19,"affiliation":536,"properties":18},{"id":537,"createTime":538,"updateTime":538,"relativeEntities":539,"slug":18,"properties":540,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"c3b4dbe3-6b58-4125-867e-95e429770c78","2024-01-12T18:31:39.035+00:00",[],{"title":541},{"VI":542},"Department of Biochemistry and Applied Molecular Biology, University of Manchester Institute of Science and Technology, Manchester, UK",{"title":544},{"VI":545},"Jeffrey J. Clare",{"id":547,"sortIndex":102,"researcher":18,"roles":548,"affiliations":549,"properties":558},"a2f4c14c-e4ff-409c-aefa-928ad3dcc378",[135],[550],{"id":18,"sortIndex":19,"affiliation":551,"properties":18},{"id":552,"createTime":553,"updateTime":553,"relativeEntities":554,"slug":18,"properties":555,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"9b999fdd-00ba-43dd-a475-2c7005933033","2023-12-04T11:58:49.734+00:00",[],{"title":556},{"VI":557},"Pfizer Central Research, Molecular Genetics Division, Groton, USA",{"title":559},{"VI":560},"Lance S. Davidow",{"id":562,"sortIndex":133,"researcher":18,"roles":563,"affiliations":564,"properties":570},"3c781775-9456-49b8-8a28-6e202077d672",[135],[565],{"id":18,"sortIndex":19,"affiliation":566,"properties":18},{"id":537,"createTime":538,"updateTime":538,"relativeEntities":567,"slug":18,"properties":568,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":569},{"VI":542},{"title":571},{"VI":572},"David C. J. Gardner",{"id":574,"sortIndex":180,"researcher":18,"roles":575,"affiliations":576,"properties":582},"a9950172-8d36-49a6-9daa-79a4e78cdcd3",[135],[577],{"id":18,"sortIndex":19,"affiliation":578,"properties":18},{"id":537,"createTime":538,"updateTime":538,"relativeEntities":579,"slug":18,"properties":580,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":581},{"VI":542},{"title":583},{"VI":165},{"url":529,"publisher":585,"properties":612},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":586,"slug":10,"properties":587,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":590,"manageAffiliations":591,"indexDatabases":592,"url":18,"thumbnailPath":18,"statistic":607,"gsStatistic":18,"type":106,"analyzePriority":18},[],{"issn":588,"title":589},{"VOID":13},{"VOID":15},[],[],[593,600],{"id":82,"indexDatabase":594,"url":97,"indexYears":18,"academicFieldIds":599,"indexDatabaseRanking":18},{"id":84,"createTime":85,"updateTime":86,"relativeEntities":595,"label":596,"description":597,"key":93,"publicationTags":598,"standard":18},[],{"EN":89,"VI":89},{"VI":91,"EN":92},[95,96],[99],{"id":62,"indexDatabase":601,"url":75,"indexYears":76,"academicFieldIds":606,"indexDatabaseRanking":80},{"id":64,"createTime":65,"updateTime":66,"relativeEntities":602,"label":603,"description":604,"key":72,"publicationTags":605,"standard":18},[],{"EN":69,"VI":69},{"EN":69,"VI":71},[74],[78,79],{"impactFactor":19,"impactFactorByYear":608,"i10Index":19,"i10IndexLast5Year":19,"totalPublication":102,"totalPublicationByYear":609,"totalCitation":19,"totalCitationByYear":610,"totalCitationPerPublication":19,"totalCitationPerPublicationByYear":611,"hindexLast5Year":19,"hindex":19},{},{"2003":102},{},{},{"volume":613,"pages":614},{"VOID":430},{"VOID":615},"449-452","1986-02-01",{"id":618,"createTime":619,"updateTime":620,"relativeEntities":621,"slug":622,"properties":623,"entityType":126,"verifyStatus":127,"verifyTime":620,"verifyNote":128,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":632,"fullTextUrl":18,"authors":633,"publicationType":216,"publisherRelationship":671,"citationCount":18,"citationInfo":18,"publishDate":704,"publishYear":705,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":252},"a4c86df3-f35d-4c33-acc7-9f30a40a65d0","2024-02-13T03:59:22.114+00:00","2025-02-12T23:58:15.250+00:00",[],"Exploiting-budding-yeast-natural-variation-for-industrial-processes",{"references":624,"abstract":626,"title":628,"doi":630},{"VOID":625},"Ambroset C, Petit M, Brion C, Sanchez I, Delobel P, Guerin C, Chiapello H, Nicolas P, Bigey F, Dequin S, Blondin B (2011) Deciphering the molecular basis of wine yeast fermentation traits using a combined genetic and genomic approach. G3 (Bethesda) 1:263–281. doi:10.1534\u002Fg3.111.000422\nApweiler E, Sameith K, Margaritis T, Brabers N, van de Pasch L, Bakker LV, van Leenen D, Holstege FC, Kemmeren P (2012) Yeast glucose pathways converge on the transcriptional regulation of trehalose biosynthesis. BMC Genom 13:239. doi:10.1186\u002F1471-2164-13-239\nBarnett JA (2007) A history of research on yeasts 10: foundations of yeast genetics. Yeast 24:799–845. doi:10.1002\u002Fyea.1513\nBergstrom A, Simpson JT, Salinas F, Barre B, Parts L, Zia A, Nguyen Ba AN, Moses AM, Louis EJ, Mustonen V, Warringer J, Durbin R, Liti G (2014) A high-definition view of functional genetic variation from natural yeast genomes. Mol Biol Evol 31:872–888. doi:10.1093\u002Fmolbev\u002Fmsu037\nBrice C, Sanchez I, Bigey F, Legras JL, Blondin B (2014) A genetic approach of wine yeast fermentation capacity in nitrogen-starvation reveals the key role of nitrogen signaling. BMC Genom 15:495. doi:10.1186\u002F1471-2164-15-495\nChidi BS, Rossouw D, Bauer FF (2016) Identifying and assessing the impact of wine acid-related genes in yeast. Curr Genet 62:149–164. doi:10.1007\u002Fs00294-015-0498-6\nCromie GA, Hyma KE, Ludlow CL, Garmendia-Torres C, Gilbert TL, May P, Huang AA, Dudley AM, Fay JC (2013) Genomic sequence diversity and population structure of Saccharomyces cerevisiae assessed by RAD-seq. G3 (Bethesda) 3:2163–2171. doi:10.1534\u002Fg3.113.007492-&gt\nCubillos FA, Coustham V, Loudet O (2012) Lessons from eQTL mapping studies: non-coding regions and their role behind natural phenotypic variation in plants. Curr Opin Plant Biol 15:192–198. doi:10.1016\u002Fj.pbi.2012.01.005\nCubillos FA, Parts L, Salinas F, Bergstrom A, Scovacricchi E, Zia A, Illingworth CJ, Mustonen V, Ibstedt S, Warringer J, Louis EJ, Durbin R, Liti G (2013) High-resolution mapping of complex traits with a four-parent advanced intercross yeast population. Genetics 195:1141–1155. doi:10.1534\u002Fgenetics.113.155515\nDuitama J, Sanchez-Rodriguez A, Goovaerts A, Pulido-Tamayo S, Hubmann G, Foulquie-Moreno MR, Thevelein JM, Verstrepen KJ, Marchal K (2014) Improved linkage analysis of Quantitative Trait Loci using bulk segregants unveils a novel determinant of high ethanol tolerance in yeast. BMC Genom 15:207. doi:10.1186\u002F1471-2164-15-207\nEhrenreich IM, Gerke JP, Kruglyak L (2009) Genetic dissection of complex traits in yeast: insights from studies of gene expression and other phenotypes in the BYxRM cross. Cold Spring Harb Symp Quant Biol 74:145–153. doi:10.1101\u002Fsqb.2009.74.013\nFay JC, McCullough HL, Sniegowski PD, Eisen MB (2004) Population genetic variation in gene expression is associated with phenotypic variation in Saccharomyces cerevisiae. Genome Biol 5:R26. doi:10.1186\u002Fgb-2004-5-4-r26\nFraser HB, Levy S, Chavan A, Shah HB, Perez JC, Zhou Y, Siegal ML, Sinha H (2012) Polygenic cis-regulatory adaptation in the evolution of yeast pathogenicity. Genome Res 22:1930–1939. doi:10.1101\u002Fgr.134080.111\nGerke J, Lorenz K, Cohen B (2009) Genetic interactions between transcription factors cause natural variation in yeast. Science 323:498–501. doi:10.1126\u002Fscience.1166426\nGibbons JG, Rinker DC (2015) The genomics of microbial domestication in the fermented food environment. Curr Opin Genet Dev 35:1–8. doi:10.1016\u002Fj.gde.2015.07.003\nGutierrez A, Beltran G, Warringer J, Guillamon JM (2013) Genetic basis of variations in nitrogen source utilization in four wine commercial yeast strains. PLoS ONE 8:e67166. doi:10.1371\u002Fjournal.pone.0067166\nHallin J, Martens K, Young A, Zackrisson M, Salinas F, Parts L, Warringer J, Lit G (2016) Powerful decomposition of complex traits in a diploid model using Phased Outbred Lines. bioRxiv http:\u002F\u002Fdx.doi.org\u002F10.1101\u002F042176\nHou J, Sigwalt A, Pflieger D, Peter J, Montigny Jd, Dunham M, Schacherer J (2016) The hidden complexity of Mendelian traits across yeast natural populations. bioRxiv http:\u002F\u002Fdx.doi.org\u002F10.1101\u002F039693\nHubmann G, Mathe L, Foulquie-Moreno MR, Duitama J, Nevoigt E, Thevelein JM (2013) Identification of multiple interacting alleles conferring low glycerol and high ethanol yield in Saccharomyces cerevisiae ethanolic fermentation. Biotechnol Biofuels 6:87. doi:10.1186\u002F1754-6834-6-87\nJara M, Cubillos FA, Garcia V, Salinas F, Aguilera O, Liti G, Martinez C (2014) Mapping genetic variants underlying differences in the central nitrogen metabolism in fermenter yeasts. PLoS ONE 9:e86533. doi:10.1371\u002Fjournal.pone.0086533\nKessi-Perez EI, Araos S, Garcia V, Salinas F, Abarca V, Larrondo LF, Martinez C, Cubillos FA (2016) RIM15 antagonistic pleiotropy is responsible for differences in fermentation and stress response kinetics in budding yeast. FEMS Yeast Res. doi:10.1093\u002Ffemsyr\u002Ffow021\nLegras JL, Merdinoglu D, Cornuet JM, Karst F (2007) Bread, beer and wine: Saccharomyces cerevisiae diversity reflects human history. Mol Ecol 16:2091–2102. doi:10.1111\u002Fj.1365-294X.2007.03266.x\nLiti G (2015) The fascinating and secret wild life of the budding yeast S. cerevisiae. Elife. doi:10.7554\u002FeLife.05835\nLiti G, Louis EJ (2012) Advances in quantitative trait analysis in yeast. PLoS Genet 8:e1002912. doi:10.1371\u002Fjournal.pgen.1002912\nLiti G, Carter DM, Moses AM, Warringer J, Parts L, James SA, Davey RP, Roberts IN, Burt A, Koufopanou V, Tsai IJ, Bergman CM, Bensasson D, O’Kelly MJ, van Oudenaarden A, Barton DB, Bailes E, Nguyen AN, Jones M, Quail MA, Goodhead I, Sims S, Smith F, Blomberg A, Durbin R, Louis EJ (2009) Population genomics of domestic and wild yeasts. Nature 458:337–341. doi:10.1038\u002Fnature07743\nMarsit S, Dequin S (2015) Diversity and adaptive evolution of Saccharomyces wine yeast: a review. FEMS Yeast Res. doi:10.1093\u002Ffemsyr\u002Ffov067\nMcManus CJ, Coolon JD, Duff MO, Eipper-Mains J, Graveley BR, Wittkopp PJ (2010) Regulatory divergence in Drosophila revealed by mRNA-seq. Genome Res 20:816–825. doi:10.1101\u002Fgr.102491.109\nPais TM, Foulquie-Moreno MR, Hubmann G, Duitama J, Swinnen S, Goovaerts A, Yang Y, Dumortier F, Thevelein JM (2013) Comparative polygenic analysis of maximal ethanol accumulation capacity and tolerance to high ethanol levels of cell proliferation in yeast. PLoS Genet 9:e1003548. doi:10.1371\u002Fjournal.pgen.1003548\nParts L, Cubillos FA, Warringer J, Jain K, Salinas F, Bumpstead SJ, Molin M, Zia A, Simpson JT, Quail MA, Moses A, Louis EJ, Durbin R, Liti G (2011) Revealing the genetic structure of a trait by sequencing a population under selection. Genome Res 21:1131–1138. doi:10.1101\u002Fgr.116731.110\nPeter J, Schacherer J (2016) Population genomics of yeasts: towards a comprehensive view across a broad evolutionary scale. Yeast 33:73–81. doi:10.1002\u002Fyea.3142\nQuerol A, Fernandez-Espinar MT, del Olmo M, Barrio E (2003) Adaptive evolution of wine yeast. Int J Food Microbiol 86:3–10\nSalinas F, Cubillos FA, Soto D, Garcia V, Bergstrom A, Warringer J, Ganga MA, Louis EJ, Liti G, Martinez C (2012) The genetic basis of natural variation in oenological traits in Saccharomyces cerevisiae. PLoS ONE 7:e49640. doi:10.1371\u002Fjournal.pone.0049640\nSalinas F, de Boer CG, Abarca V, Garcia V, Cuevas M, Araos S, Larrondo LF, Martinez C, Cubillos FA (2016) Natural variation in non-coding regions underlying phenotypic diversity in budding yeast. Sci Rep 6:21849. doi:10.1038\u002Fsrep21849\nSicard D, Legras JL (2011) Bread, beer and wine: yeast domestication in the Saccharomyces sensu stricto complex. C R Biol 334:229–236. doi:10.1016\u002Fj.crvi.2010.12.016\nSkelly DA, Merrihew GE, Riffle M, Connelly CF, Kerr EO, Johansson M, Jaschob D, Graczyk B, Shulman NJ, Wakefield J, Cooper SJ, Fields S, Noble WS, Muller EG, Davis TN, Dunham MJ, Maccoss MJ, Akey JM (2013) Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast. Genome Res 23:1496–1504. doi:10.1101\u002Fgr.155762.113\nSnoek T, Verstrepen KJ, Voordeckers K (2016) How do yeast cells become tolerant to high ethanol concentrations? Curr Genet. doi:10.1007\u002Fs00294-015-0561-3\nSteensels J, Snoek T, Meersman E, Picca Nicolino M, Voordeckers K, Verstrepen KJ (2014) Improving industrial yeast strains: exploiting natural and artificial diversity. FEMS Microbiol Rev 38:947–995. doi:10.1111\u002F1574-6976.12073\nSteyer D, Ambroset C, Brion C, Claudel P, Delobel P, Sanchez I, Erny C, Blondin B, Karst F, Legras JL (2012) QTL mapping of the production of wine aroma compounds by yeast. BMC Genom 13:573. doi:10.1186\u002F1471-2164-13-573\nSwinnen S, Schaerlaekens K, Pais T, Claesen J, Hubmann G, Yang Y, Demeke M, Foulquie-Moreno MR, Goovaerts A, Souvereyns K, Clement L, Dumortier F, Thevelein JM (2012) Identification of novel causative genes determining the complex trait of high ethanol tolerance in yeast using pooled-segregant whole-genome sequence analysis. Genome Res 22:975–984. doi:10.1101\u002Fgr.131698.111\nTesniere C, Brice C, Blondin B (2015) Responses of Saccharomyces cerevisiae to nitrogen starvation in wine alcoholic fermentation. Appl Microbiol Biotechnol 99:7025–7034. doi:10.1007\u002Fs00253-015-6810-z\nTilloy V, Ortiz-Julien A, Dequin S (2014) Reduction of ethanol yield and improvement of glycerol formation by adaptive evolution of the wine yeast Saccharomyces cerevisiae under hyperosmotic conditions. Appl Environ Microbiol 80:2623–2632. doi:10.1128\u002FAEM.03710-13\nVoordeckers K, Kominek J, Das A, Espinosa-Cantu A, De Maeyer D, Arslan A, Van Pee M, van der Zande E, Meert W, Yang Y, Zhu B, Marchal K, DeLuna A, Van Noort V, Jelier R, Verstrepen KJ (2015) Adaptation to High Ethanol Reveals Complex Evolutionary Pathways. PLoS Genet 11:e1005635. doi:10.1371\u002Fjournal.pgen.1005635\nWang QM, Liu WQ, Liti G, Wang SA, Bai FY (2012) Surprisingly diverged populations of Saccharomyces cerevisiae in natural environments remote from human activity. Mol Ecol. doi:10.1111\u002Fj.1365-294X.2012.05732.x\nWilkening S, Lin G, Fritsch ES, Tekkedil MM, Anders S, Kuehn R, Nguyen M, Aiyar RS, Proctor M, Sakhanenko NA, Galas DJ, Gagneur J, Deutschbauer A, Steinmetz LM (2014) An evaluation of high-throughput approaches to QTL mapping in Saccharomyces cerevisiae. Genetics 196:853–865. doi:10.1534\u002Fgenetics.113.160291\nWittkopp PJ, Kalay G (2012) Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence. Nat Rev Genet 13:59–69. doi:10.1038\u002Fnrg3095\nWray GA (2007) The evolutionary significance of cis-regulatory mutations. Nat Rev Genet 8:206–216. doi:10.1038\u002Fnrg2063\nZimmer A, Durand C, Loira N, Durrens P, Sherman DJ, Marullo P (2014) QTL dissection of Lag phase in wine fermentation reveals a new translocation responsible for Saccharomyces cerevisiae adaptation to sulfite. PLoS ONE 9:e86298. doi:10.1371\u002Fjournal.pone.0086298",{"EN":627},"For the last two decades, the natural variation of the yeast Saccharomyces cerevisiae has been massively exploited with the aim of understanding ecological and evolutionary processes. As a result, many new genetic variants have been uncovered, providing a large catalogue of alleles underlying complex traits. These alleles represent a rich genetic resource with the potential to provide new strains that can cope with the growing demands of industrial fermentation processes. When surveyed in detail, several of these variants have proven useful in wine and beer industries by improving nitrogen utilisation, fermentation kinetics, ethanol production, sulphite resistance and aroma production. Here, I illustrate how allele-specific expression and polymorphisms within the coding region of GDB1 underlie fermentation kinetic differences in synthetic wine must. Nevertheless, the genetic basis of how GDB1 variants and other natural alleles interact in foreign genetic backgrounds remains unclear. Further studies in large sets of strains, recombinant hybrids and multiple parental pairs will broaden our knowledge of the molecular and genetic basis of trait adaptation for utilisation in applied and industrial processes.",{"EN":629},"Exploiting budding yeast natural variation for industrial processes",{"VOID":631},"10.1007\u002Fs00294-016-0602-6","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00294-016-0602-6",[634],{"id":635,"sortIndex":19,"researcher":18,"roles":636,"affiliations":637,"properties":668},"a9f0dd99-b1da-4d09-a446-48324bb4334f",[135],[638,648,660],{"id":639,"sortIndex":102,"affiliation":640,"properties":647},"5739e0b8-994c-4423-8055-426acb593f1a",{"id":641,"createTime":642,"updateTime":642,"relativeEntities":643,"slug":18,"properties":644,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"e5bc99c5-a9b9-48ca-8cea-da1b8783fa1b","2024-02-09T11:48:27.676+00:00",[],{"title":645},{"VI":646},"Millennium Nucleus for Fungal Integrative and Synthetic Biology (MN-FISB), Santiago, Chile",{},{"id":649,"sortIndex":133,"affiliation":650,"properties":659},"9f9de544-e8b9-429c-a788-f4420fe4aea4",{"id":651,"createTime":652,"updateTime":653,"relativeEntities":654,"slug":655,"properties":656,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"917d3581-d2b2-48c4-a8de-84847115290d","2023-12-15T06:33:46.610+00:00","2024-09-28T03:12:22.259+00:00",[],"Departamento-de-Biolog%C3%ADa-Facultad-de-Qu%C3%ADmica-y-Biolog%C3%ADa-Universidad-de-Santiago-de-Chile-Santiago-Chile",{"title":657},{"VI":658},"Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile",{},{"id":18,"sortIndex":19,"affiliation":661,"properties":18},{"id":662,"createTime":663,"updateTime":663,"relativeEntities":664,"slug":18,"properties":665,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"8dcc7ebf-6af3-4a24-b704-33f46eceec0a","2024-02-13T03:59:22.132+00:00",[],{"title":666},{"VI":667},"Centro de Estudios en Ciencia y Tecnología de Alimentos (CECTA), Universidad de Santiago de Chile (USACH), Santiago, Chile",{"title":669},{"VI":670},"Francisco A. Cubillos",{"url":632,"publisher":672,"properties":699},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":673,"slug":10,"properties":674,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":677,"manageAffiliations":678,"indexDatabases":679,"url":18,"thumbnailPath":18,"statistic":694,"gsStatistic":18,"type":106,"analyzePriority":18},[],{"issn":675,"title":676},{"VOID":13},{"VOID":15},[],[],[680,687],{"id":82,"indexDatabase":681,"url":97,"indexYears":18,"academicFieldIds":686,"indexDatabaseRanking":18},{"id":84,"createTime":85,"updateTime":86,"relativeEntities":682,"label":683,"description":684,"key":93,"publicationTags":685,"standard":18},[],{"EN":89,"VI":89},{"VI":91,"EN":92},[95,96],[99],{"id":62,"indexDatabase":688,"url":75,"indexYears":76,"academicFieldIds":693,"indexDatabaseRanking":80},{"id":64,"createTime":65,"updateTime":66,"relativeEntities":689,"label":690,"description":691,"key":72,"publicationTags":692,"standard":18},[],{"EN":69,"VI":69},{"EN":69,"VI":71},[74],[78,79],{"impactFactor":19,"impactFactorByYear":695,"i10Index":19,"i10IndexLast5Year":19,"totalPublication":102,"totalPublicationByYear":696,"totalCitation":19,"totalCitationByYear":697,"totalCitationPerPublication":19,"totalCitationPerPublicationByYear":698,"hindexLast5Year":19,"hindex":19},{},{"2003":102},{},{},{"volume":700,"pages":702},{"VOID":701},"62",{"VOID":703},"745-751","2016-04-16",2016,{"id":707,"createTime":708,"updateTime":708,"relativeEntities":709,"slug":18,"properties":710,"entityType":126,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":719,"fullTextUrl":18,"authors":720,"publicationType":216,"publisherRelationship":787,"citationCount":18,"citationInfo":18,"publishDate":820,"publishYear":821,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":252},"96be16ff-69f6-4b3a-bee9-68049be5755a","2024-01-10T23:57:37.291+00:00",[],{"references":711,"abstract":713,"title":715,"doi":717},{"VOID":712},"Adomas A, Asiegbu FO (2007) Analysis of organ-specific responses of Pinus sylvestris to shoot (Gremmeniella abietina) and root (Heterobasidion annosum) pathogens. Physiol Mol Plant Pathol. doi:10.1016\u002Fj.pmpp.2007.04.001\nAlbersheim P, Anderson-Prouty A (1975) Carbohydrates, proteins, cell surfaces and the biochemistry of pathogenesis. Annu Rev Plant Physiol 26:31–52\nAnderson M, Kasuga T, Mitchelson K (1993) A partial physical karyotype of Heterobasidion annosum. In: Johansson M, Stenlid J (eds) Eighth international conference on root and butt rots. Wik, Sweden and Haikko, Finland\nAsiegbu FO (2000) Adhesion and development of the root rot fungus (Heterobasidion annosum) on conifer tissues: effects of spore and host surface constituents. FEMS Microbiol 33:101–110\nAsiegbu FO, Daniel G, Johansson M (1994) Defence related reactions of seedling roots of Norway spruce to infection by Heterobasidion annosum (Fr) Bref. Physiol Mol Plant Pathol 45:1–19\nAsiegbu FO, Johansson M, Woodward S, Hüttermann A (1998) Biochemistry in the host–parasite interaction. In: Woodward S, Stenlid J, Karjalainen R, Hüttermann A (eds) Heterobasidion annosum; biology, ecology, impact and control. CAB International, Wallingford, pp 167–193\nAsiegbu FO, Adomas A, Stenlid J (2005) Conifer root and butt rot caused by Heterobasidion annosum (Fr) Bref. s. l. Mol Plant Pathol 6:395–409\nAtkinson M (1993) Molecular mechanisms of pathogen recognition by plants. Adv Plant Pathol 10:35–64\nCapretti P, Korhonen K, Mugnai L, Romagnoli C (1990) An intersterility group of Heterobasidion annosum, specialized to Abies alba. Eur J Forest Pathol 20:231–240\nChase TE (1985) PhD Thesis, University of Vermont, Burlington\nCumagun CJR, Bowden R, Jurgenson J, Leslie J, Miedaner T (2004) Genetic mapping of pathogenicity and aggressiveness of Gibberella zeae (Fusarium graminearum) toward wheat. Phytopathology 94:520–526\nDangl JL, Jones JD (2001) Plant pathogens and integrated defence responses to infection. Nature 411:826–833\nFalconer D (1989) Introduction to quantitative genetics, 3rd. Longman Group Limited, London\nFlor H (1971) Current status of the gene for gene concept. Annu Rev Phytopathol 9:275–296\nGarbelotto M, Ratcliff A, Bruns TD, Cobb FW, Otrosina WJ (1996) Use of Taxon-specific competitive-priming PCR to study host specificity, hybridization, and intergroup gene flow in intersterility groups of Heterobasidion annosum. Phytopathology 86:543–551\nGarbelotto M, Otrosina WJ Chapela IH, Gonthier P (2001) Studies on the ecology and genetics of hybridization in Heterobasidion. In: Laflamme G, Bérubé JA, Bussières G (eds) 10th international conference on root and butt rots, pp 238–244\nGarbelotto M, Gonthier P, Nicolotti G (2004) Assessing fitness of Heterobasidion F1 hybrids through inoculation experiments. In: Manka M, Lakomy P (eds) 11th international conference on root and butt rots, pp 255–260\nGilchrist D (1998) Programmed cell death in plant disease: the purpose and promise of cellular suicide. Annu Rev Phytopathol 36:393–414\nGreenberg J, Yao N (2004) The role and regulation of programmed cell death in plant–pathogen interactions. Cell Microbiol 6:201–211\nHarrington T, Worrall JJ, Rizzo D (1989) Compatibility among host-specialized isolates of Heterobasidion annosum from western North America. Phytopathology 79:290–296\nHawthorne B, Rees-George J, Bowen J, Ball R (1997) A single locus with a large effect on virulence in Nectria haematococca MPI. Fungal Genet Newsl 44:24–26\nHeath M (2000) Hypersensitive response-related death. Plant Mol Biol 44:321–334\nHolz G, Coertze S, Williamson B (2004) The ecology of Botrytis on plant surfaces. In: Elad Y, Williamson B, Tudzynski P, Delen N (eds) Botrytis: biology, pathology and control. Kluwer, Dordrecht, pp 9–27\nJiang R, Weide R, de Vondervoort P, Govers F (2006) Amplification generates modular diversity at an avirulence locus in the pathogen Phytophthora. Genome Res 16:827–840\nJohansson M (1988) Pectic enzyme activity of spruce (S) and pine (P) strains of Heterobasidion annosum (Fr) Bref. Physiol Mol Plant Pathol 33:333–349\nJohansson M, Lundgren L, Asiegbu FO (1994) Initial interactions in living bark and sapwood of conifers infected by root rot fungi. In: Aamlid D (ed) Proceedings from the SNS meetings in forest pathology. Biri, Norway, pp 12–16\nJohansson M, Denekamp M, Asiegbu FO (1999) Production and isozyme pattern of extracellular laccase in the S and P intersterility groups of the root pathogen Heterobasidion annosum. Mycol Res 103:365–371\nJones E (1994) Fungal adhesion. Mycol Res 98:961–981\nKarlsson J, Stenlid J (1991) Pectic isozyme profiles of the intersterility groups in Heterobasidion annosum. Mycol Res 95:531–536\nKarlsson M, Olson Å, Stenlid J (2003) Expressed sequences from the basidiomycetous tree pathogen Heterobasidion annosum during early infection of scots pine. Fungal Genet Biol 39:51–59\nKarlsson M, Stenlid J, Olson Å (2005) Identification of a superoxide dismutase gene from the conifer pathogen Heterobasidion annosum. Physiol Mol Plant Pathol 66:99–107\nKnoche H, Duvick J (1987) The role of fungal toxins in plant disease. In: Pegg G, Ayres P (eds) Fungal infection of plants. Cambridge University Press, Cambridge, pp 158–191\nKorhonen K (1978) Intersterility groups of Heterobasidion annosum. Comm Inst For Fenn 94:1–25\nKorhonen K, Stenlid J (1998) Biology of Heterobasidion annosum. In: Woodward S, Stenlid J, Karjalainen R, Hüttermann A (eds) Heterobasidion annosum: biology, ecology, impact and control. CAB International. Wallingford, pp 43–70\nKubisiak TL, Amerson HV, Nelson CD (2005) Genetic interaction of the fusiform rust fungus with resistance gene Fr1 in loblolly pine. Phytopathology 95:376–380\nLander ES, Botstein D (1988) Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121:185–199\nLarraya LM, Idareta E, Arana D, Ritter E, Pisabarro AG, Ramirez L (2002) Quantitative trait loci controlling vegetative growth rate in the edible Basidiomycete Pleurotus ostreatus. Appl Environ Microbiol 68:1109–1114\nLarraya LM, Alfonso M, Pisabarro AG, Ramirez L (2003) Mapping of genomic regions (quantitative trait loci) controlling production and quality in industrial cultures of the edible Basidiomycete Pleurotus ostreatus. Appl Environ Microbiol 69:3617–3625\nLind M, Olson Å, Stenlid J (2005) An AFLP-marker based genetic linkage map of Heterobasidion annosum locating intersterility genes. Fungal Genet Biol 42:519–527\nLindberg M, Johansson M (1991) Growth of Heterobasidion annosum through bark of Picea abies. Eur J Forest Pathol 21:377–388\nLyon GD, Goodman BA, Williamson B (2004) Botrytis cinerea perturbs redox strategies as an attack strategy in plants. In: Elad Y, Williamson B, Tudzynski P, Delen N (eds) Botrytis: biology, pathology and control. Kluwer, Dordrecht, pp 119–141\nManocha M (1984) Cell surface characteristics of Mortierella and their interaction with a mycoparasite. Can J Microbiol 30:290–298\nMoquet F, Desmerger C, Mamoun M, Ramos-Guedes-Lafargue M, Olivier J-M (1999) A quantitative trait locus of Agaricus bisporus resistance to Pseudomonas tolaasii is closely linked to natural cap color. Fungal Genet Biol 28:34–42\nMorel JB, Dangl J (1997) The hypersensitive response and the induction of cell death in plants. Cell Death Diff 4:671–683\nNiemelä T, Korhonen K (1998) Taxonomy of the genus Heterobasidion. In: Woodward S, Stenlid J, Karjalainen R, Hüttermann A (eds) Heterobasidion annosum: biology, ecology, impact and control. CAB International. Wallingford, pp 27–33\nOlson Å (2006) Genetic linkage between growth rate and the intersterility genes S and P in the basidiomycete Heterobasidion annosum s.l. Mycol Res 110:979–984\nOlson Å, Stenlid J (2001) Mitochondrial control of fungal hybrid virulence. Nature 411:438\nOlson Å, Lind M, Stenlid J (2005) In vitro test of virulence in the progeny of a Heterobasidion interspecific cross. For Pathol 35:321–331\nSamils N, Elfstrand M, Lindner Czederpiltz D L, Fahleson J, Olson Å, Dixelius C, Stenlid S (2006) Development of a rapid and simple Agrobacterium tumefaciens-mediated transformation system for the fungal pathogen Heterobasidion annosum. FEMS Microbiol Lett 255:82–88\nSiegee D (1993) Bacterial plant pathology; cell and molecular aspects. Cambridge University Press, Cambridge, pp 126–171\nSierotzki H, Gessler C (1998) Genetic analysis of a cross of two Venturia inaequalis strains that differ in virulence. J Phytopathol 146:515–519\nSoanes DM, Talbot NJ (2006) Comparative genomic analysis of phytopathogenic fungi using expressed sequence tag (EST) collections. Mol Plant Pathol 7:61–71\nStenlid J (1985) Population structure of Heterobasidion annosum as determined by somatic incompatibility, sexual incompatibility and isoenzyme patterns. Can J Bot 63:2268–2273\nStenlid J, Karlsson J (1991) Partial intersterility in Heterobasidion annosum. Mycol Res 95:1153–1159\nSwedjemark G, Johannesson H, Stenlid J (1999) Intraspecific variation in Heterobasidion annosum for growth in sapwood of Picea abies and Pinus silvestris. Eur J Forest Pathol 29:249–258\nSwedjemark G, Stenlid J, Karlsson B (2001) Variation in growth of Heterobasidion annosum among clones of Picea abies incubated for different periods of time. For Pathol 31:163–175\nThrall PH, Burdon JJ (2003) Evolution of virulence in a plant host–pathogen metapopulation. Science 299:1735–1737\nVan Ooijen J, Boer MP, Jansen RC, Maliepaard C (2002) MapQTL 4.0, Software for the calculation of QTL positions on genetic maps. Plant Research International, Wageningen, the Neterlands\nVinatzer B, Patocchi A, Gianfranceschi L, Tartarini S, Zhang H, Gessler C, Sansavini S (2001) Apple contains receptor-like genes homologous to the Cladosporium fulvum resistance gene family of tomato with a cluster of genes cosegregating with Vf apple scab resistance. Mol Plant Microbe Interact 14:508–515\nWelz H, Leonard K (1994) Genetic analysis of two race 0 X race 2 crosses in Cochliobolus carbonum. Phytopathology 84:83–91\nWilcox PL, Amerson HV, Kuhlman EG, Liu BH, OMalley DM, Sederoff RR (1996) Detection of a major gene for resistance to fusiform rust disease in loblolly pine by genomic mapping. PNAS 93:3859–3864\nWolpert T, Dunkle L, Ciuffetti LM (2002) Host-selective toxins and avirulence determinants: What’s in a name? Annu Rev Phytopathol 40:251–285\nWoodward S, Stenlid J, Karjalainen R, Hûttermann A (1998) Heterobasidion annosum. Biology, ecology, impact and control. CAB International, Cambridge\nZhan J, Mundt CC, Hoffer ME, McDonald BA (2002) Local adaptation and effect of host genotype on the rate of pathogen evolution: an experimental test in a plant pathosystem. J Evol Biol 15:634–647\nZhong S, Steffenson BJ (2002) Identification and characterization of DNA markers associated with a locus conferring virulence on barley in the plant pathogenic fungus Cochliobolus sativus. Theor Appl Genet 104:1049–1054",{"EN":714},"Identification of virulence factors of phytopathogens is important for the fundamental understanding of infection and disease progress in plants and for the development of control strategies. We have identified quantitative trait loci (QTL) for virulence on 1-year-old Pinus sylvestris and 2-year-old Picea abies seedlings and positioned them on a genetic linkage map of the necrotrophic phytopathogen Heterobasidion annosum sensu lato (s.l.), a major root rot pathogen on conifers. The virulence of 102 progeny isolates was analysed using two measurements: lesion lengths and fungal growth in sapwood from a cambial infection site. We found negative virulence effects of hybridization although this was contradicted on a winter-hardened spruce. On P. abies, both measurements identified several partially overlapping QTLs on linkage group (LG) 15 of significant logarithm of odds (LOD) values ranging from 2.31 to 3.85. On P. sylvestris, the lesion length measurement also identified a QTL (LOD 3.09) on LG 15. Moreover, QTLs on two separate smaller LGs, with peak LOD values of 2.78 and 4.58 were identified for fungal sapwood growth and lesion lengths, respectively. The QTL probably represent loci important for specific as well as general aspects of virulence on P. sylvestris and P. abies.",{"EN":716},"Identification of quantitative trait loci affecting virulence in the basidiomycete Heterobasidion annosum s.l.",{"VOID":718},"10.1007\u002Fs00294-007-0137-y","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00294-007-0137-y",[721,736,748,760,775],{"id":722,"sortIndex":19,"researcher":18,"roles":723,"affiliations":724,"properties":733},"7e2fb5dc-8592-4c42-9bfc-1f6789164434",[135],[725],{"id":18,"sortIndex":19,"affiliation":726,"properties":18},{"id":727,"createTime":728,"updateTime":728,"relativeEntities":729,"slug":18,"properties":730,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"6010afa8-22d8-44bb-8745-bef46900b1b9","2023-12-24T18:09:19.450+00:00",[],{"title":731},{"VI":732},"Department of Forest Mycology and Pathology, Swedish University of Agricultural Sciences, Uppsala, Sweden",{"title":734},{"VI":735},"Mårten Lind",{"id":737,"sortIndex":205,"researcher":18,"roles":738,"affiliations":739,"properties":745},"1b7231fb-b9c1-4cea-89df-f3b2f349bc8c",[135],[740],{"id":18,"sortIndex":19,"affiliation":741,"properties":18},{"id":727,"createTime":728,"updateTime":728,"relativeEntities":742,"slug":18,"properties":743,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":744},{"VI":732},{"title":746},{"VI":747},"Åke Olson",{"id":749,"sortIndex":133,"researcher":18,"roles":750,"affiliations":751,"properties":757},"7582b30a-5112-48b3-8cc5-17c7c1b24358",[135],[752],{"id":18,"sortIndex":19,"affiliation":753,"properties":18},{"id":727,"createTime":728,"updateTime":728,"relativeEntities":754,"slug":18,"properties":755,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":756},{"VI":732},{"title":758},{"VI":759},"Jan Stenlid",{"id":761,"sortIndex":180,"researcher":18,"roles":762,"affiliations":763,"properties":772},"8276081a-7803-4a71-8d01-4b859b33dc0f",[135],[764],{"id":18,"sortIndex":19,"affiliation":765,"properties":18},{"id":766,"createTime":767,"updateTime":767,"relativeEntities":768,"slug":18,"properties":769,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"4cc5ff4f-a6a3-49bd-98ae-f4693ec92e00","2024-01-10T23:57:37.336+00:00",[],{"title":770},{"VI":771},"Skogforsk, Ekebo, Svalöv, Sweden",{"title":773},{"VI":774},"Bo Karlsson",{"id":776,"sortIndex":102,"researcher":18,"roles":777,"affiliations":778,"properties":784},"834c9a10-f819-4235-9da2-ec2b29f97787",[135],[779],{"id":18,"sortIndex":19,"affiliation":780,"properties":18},{"id":727,"createTime":728,"updateTime":728,"relativeEntities":781,"slug":18,"properties":782,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":783},{"VI":732},{"title":785},{"VI":786},"Kerstin Dalman",{"url":719,"publisher":788,"properties":815},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":789,"slug":10,"properties":790,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":793,"manageAffiliations":794,"indexDatabases":795,"url":18,"thumbnailPath":18,"statistic":810,"gsStatistic":18,"type":106,"analyzePriority":18},[],{"issn":791,"title":792},{"VOID":13},{"VOID":15},[],[],[796,803],{"id":82,"indexDatabase":797,"url":97,"indexYears":18,"academicFieldIds":802,"indexDatabaseRanking":18},{"id":84,"createTime":85,"updateTime":86,"relativeEntities":798,"label":799,"description":800,"key":93,"publicationTags":801,"standard":18},[],{"EN":89,"VI":89},{"VI":91,"EN":92},[95,96],[99],{"id":62,"indexDatabase":804,"url":75,"indexYears":76,"academicFieldIds":809,"indexDatabaseRanking":80},{"id":64,"createTime":65,"updateTime":66,"relativeEntities":805,"label":806,"description":807,"key":72,"publicationTags":808,"standard":18},[],{"EN":69,"VI":69},{"EN":69,"VI":71},[74],[78,79],{"impactFactor":19,"impactFactorByYear":811,"i10Index":19,"i10IndexLast5Year":19,"totalPublication":102,"totalPublicationByYear":812,"totalCitation":19,"totalCitationByYear":813,"totalCitationPerPublication":19,"totalCitationPerPublicationByYear":814,"hindexLast5Year":19,"hindex":19},{},{"2003":102},{},{},{"volume":816,"pages":818},{"VOID":817},"52",{"VOID":819},"35-44","2007-06-14",2007,{"id":823,"createTime":824,"updateTime":825,"relativeEntities":826,"slug":827,"properties":828,"entityType":126,"verifyStatus":127,"verifyTime":825,"verifyNote":128,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":837,"fullTextUrl":18,"authors":838,"publicationType":216,"publisherRelationship":866,"citationCount":18,"citationInfo":18,"publishDate":898,"publishYear":434,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":252},"8ce14308-f222-4857-ae9e-95b20f7aab5c","2024-01-19T14:35:27.532+00:00","2025-02-15T23:56:35.015+00:00",[],"The-subunit-I-of-the-respiratory-chain-NADH-dehydrogenase-from-Cephalosporium-acremonium-the-evolution-of-a-mitochondrial-gene",{"references":829,"abstract":831,"title":833,"doi":835},{"VOID":830},"Anderson S, Bankier AT, Barrell BG, de Bruijn MHL, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJH, Staden R, Young IJ (1981) Nature (London) 290:457–465\nAnderson S, de Bruijn MHL, Coulson AR, Eperon IC, Sanger F, Young IG (1982) J Mol Biol 156:683–717\nBibb MJ, Van Etten RA, Wright CT, Walberg WM, Clayton DA (1981) Cell 26:167–180\nBrown TA, Davies RW, Ray JA, Waring RB, Scazzocchio C (1983) EMBO J 2:427–435\nBrown TA, Waring RB, Scazzocchio C, Davies RW (1985) Curr Genet 9:113–117\nChen M, Anné J, Volckaert G, Huysmans E, Vandenberghe A, De Wachter R (1984) Nucleic Acids Res 12:4881–4892\nChomyn A, Mariottini P, Cleeter MWJ, Ragan CI, Matsuno-Yagi A, Hatefi Y, Doolitle RF, Attardi G (1985) Nature (London) 314:592–597\nChou PY, Fasman GD (1978) Annu Rev Biochem 47:251–276\nClary DO, Goddard JM, Martin SC, Fauron CMR, Wolstenholme DR (1982) Nucleic Acids Res 10:6619–6637\nKyte J, Doolittle RF (1982) J Mol Biol 157:105–132\nLipman DJ, Pearson WR (1985) Science 27:1435–1441\nPeñalva MA, Touriño A, Patiño C, Sánchez F, Fernández-Sousa JM, Rubio V (1985) In: Timberlake W (ed) Molecular genetics of filamentous fungi. Liss, New York, pp 59–68 (UCLA Symposia on Molecular and Cellular Biology, new series, vol 34)\nPeñalva MA, Patiño C, Rubio V (1986) FEBS Lett 198:92–98\nSamson SM, Belagaje R, Blankenship DT, Chapman JL, Perry D, Skatrud PL, VanFrank RM, Abraham EP, Baldwin JE, Queener SW, Ingolia TD (1985) Nature (London) 318:191–194\nSanger F, Nicklen S, Coulson AR (1977) Natl Acad Sci USA 74:5463–5467\nStaden R, McLachlan AD (1982) Nucleic Acids Res 10:141–156\nZamaroczy M, Bernardi G (1985) Gene 37:1–17",{"EN":832},"A Cephalosporium acremonium mitochondrial gene equivalent to human URF1 has been identified. The primary structure of the protein is highly homologous to its human (39%) and A. nidulans (66%) counterparts. Hydrophobicity profiles and predicted secondary structures are also very similar suggesting that this gene codes for the subunit I of the respiratory-chain NADH dehydrogenase. The nucleotide sequence of the gene, 70% homologous to the A. nidulans one, presents a high AT content (72%) and this fact is reflected in the codon usage.",{"EN":834},"The subunit I of the respiratory-chain NADH dehydrogenase from Cephalosporium acremonium: the evolution of a mitochondrial gene",{"VOID":836},"10.1007\u002FBF00418525","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002FBF00418525",[839,854],{"id":840,"sortIndex":19,"researcher":18,"roles":841,"affiliations":842,"properties":851},"91ccb9b5-83c9-49ac-889f-2050275d040e",[135],[843],{"id":18,"sortIndex":19,"affiliation":844,"properties":18},{"id":845,"createTime":846,"updateTime":846,"relativeEntities":847,"slug":18,"properties":848,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"e27381a8-7924-4f2c-ae89-29f9424d8d68","2024-01-19T14:35:27.548+00:00",[],{"title":849},{"VI":850},"Laboratorio de Genética Molecular, Antibióticos S.A., Madrid, Spain",{"title":852},{"VI":853},"Miguel A. Peñalva",{"id":855,"sortIndex":102,"researcher":18,"roles":856,"affiliations":857,"properties":863},"8e609bbf-e91b-462a-9bff-4e78e0fb4736",[135],[858],{"id":18,"sortIndex":19,"affiliation":859,"properties":18},{"id":845,"createTime":846,"updateTime":846,"relativeEntities":860,"slug":18,"properties":861,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":862},{"VI":850},{"title":864},{"VI":865},"Jose L. Garcia",{"url":837,"publisher":867,"properties":894},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":868,"slug":10,"properties":869,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":872,"manageAffiliations":873,"indexDatabases":874,"url":18,"thumbnailPath":18,"statistic":889,"gsStatistic":18,"type":106,"analyzePriority":18},[],{"issn":870,"title":871},{"VOID":13},{"VOID":15},[],[],[875,882],{"id":82,"indexDatabase":876,"url":97,"indexYears":18,"academicFieldIds":881,"indexDatabaseRanking":18},{"id":84,"createTime":85,"updateTime":86,"relativeEntities":877,"label":878,"description":879,"key":93,"publicationTags":880,"standard":18},[],{"EN":89,"VI":89},{"VI":91,"EN":92},[95,96],[99],{"id":62,"indexDatabase":883,"url":75,"indexYears":76,"academicFieldIds":888,"indexDatabaseRanking":80},{"id":64,"createTime":65,"updateTime":66,"relativeEntities":884,"label":885,"description":886,"key":72,"publicationTags":887,"standard":18},[],{"EN":69,"VI":69},{"EN":69,"VI":71},[74],[78,79],{"impactFactor":19,"impactFactorByYear":890,"i10Index":19,"i10IndexLast5Year":19,"totalPublication":102,"totalPublicationByYear":891,"totalCitation":19,"totalCitationByYear":892,"totalCitationPerPublication":19,"totalCitationPerPublicationByYear":893,"hindexLast5Year":19,"hindex":19},{},{"2003":102},{},{},{"volume":895,"pages":896},{"VOID":430},{"VOID":897},"797-801","1986-07-01",{"id":900,"createTime":901,"updateTime":902,"relativeEntities":903,"slug":904,"properties":905,"entityType":126,"verifyStatus":127,"verifyTime":902,"verifyNote":128,"syncStatus":17,"languages":918,"translateLanguages":18,"viewCount":19,"primaryUrl":920,"fullTextUrl":18,"authors":921,"publicationType":216,"publisherRelationship":1084,"citationCount":1119,"citationInfo":1120,"publishDate":1122,"publishYear":1123,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":1124,"isForceReanalyzing":252},"34477dd7-cea1-4794-9fc2-7e7b66e08279","2024-04-20T08:40:52.154+00:00","2025-01-21T23:56:16.407+00:00",[],"The-International-Symposium-on-Fungal-Stress-ISFUS",{"mag":906,"keywords":908,"openalex":909,"abstract":911,"title":912,"pm":914,"doi":916},{"VOID":907},"2238301160",{},{"VOID":910},"W2238301160",{},{"EN":913},"The International Symposium on Fungal Stress: ISFUS",{"VOID":915},"26100601",{"VOID":917},"10.1007\u002Fs00294-015-0501-2",[919],"EN","http:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs00294-015-0501-2",[922,943,963,983,998,1019,1042,1062],{"id":923,"sortIndex":133,"researcher":18,"roles":924,"affiliations":925,"properties":936},"dc860807-f0b5-4597-ad6c-2485669fd5d3",[],[926],{"id":927,"sortIndex":19,"affiliation":928,"properties":18},"3ca5880b-7d76-4cc7-9096-8abc09d2f1a0",{"id":929,"createTime":930,"updateTime":930,"relativeEntities":931,"slug":932,"properties":933,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"cadcce2a-6b9c-469c-bbd0-b85dcfe994c4","2024-04-20T08:40:52.247+00:00",[],"Departments-of-Radiology-and-Microbiology-and-Immunology-Albert-Einstein-College-of-Medicine-1695A-Eastchester-Road-Bronx-NY-10461-USA",{"title":934},{"EN":935},"Departments of Radiology and Microbiology and Immunology, Albert Einstein College of Medicine, 1695A Eastchester Road, Bronx, NY, 10461, USA",{"openalex":937,"orcid":939,"title":941},{"VOID":938},"A5034610205",{"VOID":940},"https:\u002F\u002Forcid.org\u002F0000-0001-7300-6479",{"EN":942},"Ekaterina Dadachova",{"id":944,"sortIndex":19,"researcher":18,"roles":945,"affiliations":946,"properties":956},"0e8cc396-6a7f-4b26-ba9e-f53292d4a341",[],[947],{"id":948,"sortIndex":19,"affiliation":949,"properties":18},"7e1045d2-522d-42b6-8518-45ce23bc10e7",{"id":950,"createTime":951,"updateTime":951,"relativeEntities":952,"slug":18,"properties":953,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"ba4bea0a-a9c1-40a0-bf08-f32ba341537e","2024-02-12T12:12:38.181+00:00",[],{"title":954},{"VI":955},"Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraíba, São José dos Campos, SP 12244-000, Brazil",{"openalex":957,"orcid":959,"title":961},{"VOID":958},"A5018563668",{"VOID":960},"https:\u002F\u002Forcid.org\u002F0000-0001-7188-100X",{"EN":962},"Drauzio E.N. Rangel",{"id":964,"sortIndex":205,"researcher":18,"roles":965,"affiliations":966,"properties":978},"663729b5-4c01-4dec-8bc8-bfcbd4263383",[],[967],{"id":968,"sortIndex":19,"affiliation":969,"properties":18},"aeaee1e4-6273-4143-94e1-786af09ca3f2",{"id":970,"createTime":971,"updateTime":972,"relativeEntities":973,"slug":974,"properties":975,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"b8daf7e7-6159-476b-81b4-55e80264c3fd","2023-12-28T18:11:29.679+00:00","2024-10-05T04:34:56.524+00:00",[],"CBS-KNAW-Fungal-Biodiversity-Centre-Uppsalalaan-8-3584-CT-Utrecht-The-Netherlands",{"title":976},{"VI":977},"CBS-KNAW Fungal Biodiversity Centre, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands",{"openalex":979,"title":981},{"VOID":980},"A5090780993",{"EN":982},"Jan Dijksterhuis",{"id":984,"sortIndex":102,"researcher":18,"roles":985,"affiliations":986,"properties":993},"c7d95f1a-af93-4928-816b-df10d123a5a3",[],[987],{"id":988,"sortIndex":19,"affiliation":989,"properties":18},"c944ba95-7b47-4233-beda-1e66d39bc094",{"id":950,"createTime":951,"updateTime":951,"relativeEntities":990,"slug":18,"properties":991,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":992},{"VI":955},{"openalex":994,"title":996},{"VOID":995},"A5071064759",{"EN":997},"Alene Alder-Rangel",{"id":999,"sortIndex":180,"researcher":18,"roles":1000,"affiliations":1001,"properties":1012},"2ced16c3-12de-492b-abd8-5b1b1748758b",[],[1002],{"id":1003,"sortIndex":19,"affiliation":1004,"properties":18},"5295aaad-c004-4c85-a73c-7883bd7e202f",{"id":1005,"createTime":1006,"updateTime":1006,"relativeEntities":1007,"slug":1008,"properties":1009,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"7f8661e7-17eb-4d35-b4a8-8ed16a180449","2024-04-20T08:40:52.308+00:00",[],"Uppsala-BioCenter-Department-Forest-Mycology-and-Plant-Pathology-Swedish-University-of-Agricultural-Sciences-75007-Uppsala-Sweden",{"title":1010},{"EN":1011},"Uppsala BioCenter, Department Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences, 75007, Uppsala, Sweden",{"openalex":1013,"orcid":1015,"title":1017},{"VOID":1014},"A5068227654",{"VOID":1016},"https:\u002F\u002Forcid.org\u002F0000-0002-3652-2930",{"EN":1018},"Roger D. Finlay",{"id":1020,"sortIndex":1021,"researcher":18,"roles":1022,"affiliations":1023,"properties":1035},"28210b34-4a75-4736-893a-e4413a347779",7,[],[1024],{"id":1025,"sortIndex":19,"affiliation":1026,"properties":18},"53e31e81-1378-4395-b3e6-402c8e1c9005",{"id":1027,"createTime":1028,"updateTime":1029,"relativeEntities":1030,"slug":1031,"properties":1032,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"89162f11-77ee-4d55-aa42-2d2dd44f9e74","2024-04-20T08:40:52.375+00:00","2024-09-18T01:10:41.598+00:00",[],"Institute-for-Global-Food-Security-School-of-Biological-Sciences-Queen-s-University-Belfast-MBC-97-Lisburn-Road-Belfast-BT9-7BL-UK",{"title":1033},{"EN":1034},"Institute for Global Food Security, School of Biological Sciences, Queen’s University Belfast, MBC, 97 Lisburn Road, Belfast, BT9 7BL, UK",{"openalex":1036,"orcid":1038,"title":1040},{"VOID":1037},"A5076096411",{"VOID":1039},"https:\u002F\u002Forcid.org\u002F0000-0001-6797-9362",{"EN":1041},"John E. Hallsworth",{"id":1043,"sortIndex":150,"researcher":18,"roles":1044,"affiliations":1045,"properties":1055},"05e22f62-68fa-4f37-8310-65e28249389b",[],[1046],{"id":1047,"sortIndex":19,"affiliation":1048,"properties":18},"a6987ad6-6ec4-4455-a67c-dcc50f5b1d72",{"id":1049,"createTime":1050,"updateTime":1050,"relativeEntities":1051,"slug":18,"properties":1052,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"a6220560-ff6a-4285-a797-d557bbd3cae1","2024-01-26T01:21:32.913+00:00",[],{"title":1053},{"VI":1054},"Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP 14040-903, Brazil",{"openalex":1056,"orcid":1058,"title":1060},{"VOID":1057},"A5035934087",{"VOID":1059},"https:\u002F\u002Forcid.org\u002F0000-0002-4787-4704",{"EN":1061},"Gilberto Úbida Leite Braga",{"id":1063,"sortIndex":1064,"researcher":18,"roles":1065,"affiliations":1066,"properties":1077},"1d7d60fc-4412-4af3-af1c-3bd86f822dc3",6,[],[1067],{"id":1068,"sortIndex":19,"affiliation":1069,"properties":18},"7b966d88-1cdd-4c4b-9ae4-130a3e1080db",{"id":1070,"createTime":1071,"updateTime":1071,"relativeEntities":1072,"slug":1073,"properties":1074,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"59d600bd-a959-4681-9dff-8171e0328290","2024-04-20T08:40:52.366+00:00",[],"Departamento-de-Gen%C3%A9tica-Facultad-de-Biolog%C3%ADa-Universidad-de-Sevilla-Avenida-Reina-Mercedes-6-Apartado-1095-41080-Seville-Spain",{"title":1075},{"EN":1076},"Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Avenida Reina Mercedes 6, Apartado 1095, 41080, Seville, Spain",{"openalex":1078,"orcid":1080,"title":1082},{"VOID":1079},"A5067242395",{"VOID":1081},"https:\u002F\u002Forcid.org\u002F0000-0002-6282-6567",{"EN":1083},"Luis M. Corrochano",{"url":18,"publisher":1085,"properties":1112},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1086,"slug":10,"properties":1087,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1090,"manageAffiliations":1091,"indexDatabases":1092,"url":18,"thumbnailPath":18,"statistic":1107,"gsStatistic":18,"type":106,"analyzePriority":18},[],{"issn":1088,"title":1089},{"VOID":13},{"VOID":15},[],[],[1093,1100],{"id":82,"indexDatabase":1094,"url":97,"indexYears":18,"academicFieldIds":1099,"indexDatabaseRanking":18},{"id":84,"createTime":85,"updateTime":86,"relativeEntities":1095,"label":1096,"description":1097,"key":93,"publicationTags":1098,"standard":18},[],{"EN":89,"VI":89},{"VI":91,"EN":92},[95,96],[99],{"id":62,"indexDatabase":1101,"url":75,"indexYears":76,"academicFieldIds":1106,"indexDatabaseRanking":80},{"id":64,"createTime":65,"updateTime":66,"relativeEntities":1102,"label":1103,"description":1104,"key":72,"publicationTags":1105,"standard":18},[],{"EN":69,"VI":69},{"EN":69,"VI":71},[74],[78,79],{"impactFactor":19,"impactFactorByYear":1108,"i10Index":19,"i10IndexLast5Year":19,"totalPublication":102,"totalPublicationByYear":1109,"totalCitation":19,"totalCitationByYear":1110,"totalCitationPerPublication":19,"totalCitationPerPublicationByYear":1111,"hindexLast5Year":19,"hindex":19},{},{"2003":102},{},{},{"volume":1113,"pages":1115,"issue":1117},{"VOID":1114},"61",{"VOID":1116},"479-487",{"VOID":1118},"3",10,{"total":1119,"publishYear":18,"statisticByYear":1121},{"2018":1021,"2020":133,"2023":102},"2015-08-01",2015,[1125,1128,1131,1135,1138,1142,1146,1150,1154,1158,1162,1166,1170,1174,1177,1181,1185,1189,1193,1197,1200,1203,1207,1211,1215,1219,1223,1227,1231,1235,1239,1243,1247,1251,1255,1259,1263,1267,1271,1275,1279,1283,1287,1291,1295,1299,1303,1307,1311,1315,1319,1323,1327,1331,1335,1339,1343,1347,1351,1355,1359,1362,1366,1370,1374,1378,1381,1385,1389,1393,1397,1401,1405,1409,1412,1415,1419,1423,1427,1431,1434,1437,1441,1445,1448,1452,1456,1460,1464,1468,1472,1476,1480,1484,1488,1492,1495,1499],{"id":18,"text":1126,"url":18,"identifiers":1127},"Agrios GN (1997) Plant Pathology, 4th edn. Academic Press, San Diego",{},{"id":18,"text":1129,"url":18,"identifiers":1130},"Alder-Rangel A (2015) The adventures of  Dr. Donald W. Roberts: International Insect Pathologist (in press)",{},{"id":18,"text":1132,"url":18,"identifiers":1133},"Alston DG, Rangel DEN, Lacey LA, Golez HG, Kim JJ, Roberts DW (2005) Evaluation of novel fungal and nematode isolates for control of Conotrachelus nenuphar (Coleoptera: Curculionidae) larvae. Biol Control 35:163–171",{"doi":1134},"10.1016\u002Fj.biocontrol.2005.06.011",{"id":18,"text":1136,"url":18,"identifiers":1137},"Alves FL, Stevenson A, Baxter E, Gillion JLM, Hejazi F, Hayes S, Morrison IEG, Prior BA, McGenity TJ, Rangel DEN, Magan N, Timmis KN, Hallsworth JE (2015) Concomitant osmotic and chaotropicity-induced stresses in Aspergillus wentii: compatible solutes determine the biotic window. Curr Genet. doi: 10.1007\u002Fs00294-015-0496-8",{},{"id":18,"text":1139,"url":18,"identifiers":1140},"Avalos J, Limón MC (2014) Biological roles of fungal carotenoids Curr Genet doi: 10.1007\u002Fs00294-014-0454-x",{"doi":1141},"10.1007\u002Fs00294-014-0454-x",{"id":18,"text":1143,"url":18,"identifiers":1144},"Azevedo RFF, Souza RKF, Braga GUL, Rangel DEN (2014) Responsiveness of entomopathogenic fungi to menadione-induced oxidative stress. Fungal Biol 118:990–995. doi: 10.1016\u002Fj.funbio.2014.09.003",{"doi":1145},"10.1016\u002Fj.funbio.2014.09.003",{"id":18,"text":1147,"url":18,"identifiers":1148},"Ball P, Hallsworth JE (2015) Water structure and chaotropicity: their uses, abuses and biological implications. Phys Chem Chem Phys 17:8297–8305. doi: 10.1039\u002Fc4cp04564e",{"doi":1149},"10.1039\u002FC4CP04564E",{"id":18,"text":1151,"url":18,"identifiers":1152},"Bhaganna P, Volkers RJM, Bell ANW, Kluge K, Timson DJ, McGrath JW, Ruijssenaars HJ, Hallsworth JE (2010) Hydrophobic substances induce water stress in microbial cells. Microb Biotechnol 3:701–716. doi: 10.1111\u002Fj.1751-7915.2010.00203.x",{"doi":1153},"10.1111\u002Fj.1751-7915.2010.00203.x",{"id":18,"text":1155,"url":18,"identifiers":1156},"Bischoff JF, Rehner SA, Humber RA (2009) A multilocus phylogeny of the Metarhizium anisopliae lineage. Mycologia 101:512–530",{"doi":1157},"10.3852\u002F07-202",{"id":18,"text":1159,"url":18,"identifiers":1160},"Braga GUL, Flint SD, Messias CL, Anderson AJ, Roberts DW (2001a) Effect of UV-B on conidia and germlings of the entomopathogenic hyphomycete Metarhizium anisopliae. Mycol Res 105:874–882",{"doi":1161},"10.1017\u002FS0953756201004270",{"id":18,"text":1163,"url":18,"identifiers":1164},"Braga GUL, Flint SD, Messias CL, Anderson AJ, Roberts DW (2001b) Effects of UV-B irradiance on conidia and germinants of the entomopathogenic hyphomycete Metarhizium anisopliae: a study of reciprocity and recovery. Photochem Photobiol 73:140–146",{"doi":1165},"10.1562\u002F0031-8655(2001)073\u003C0140:EOUIOC>2.0.CO;2",{"id":18,"text":1167,"url":18,"identifiers":1168},"Braga GUL, Flint SD, Miller CD, Anderson AJ, Roberts DW (2001c) Variability in response to UV-B among species and strains of Metarhizium anisopliae isolates from sites at latitudes from 61°N to 54°S. J Invertebr Pathol 78:98–108",{"doi":1169},"10.1006\u002Fjipa.2001.5048",{"id":18,"text":1171,"url":18,"identifiers":1172},"Braga GUL, Rangel DEN, Flint SD, Anderson AJ, Roberts DW (2006) Conidial pigmentation is important to tolerance against solar-simulated radiation in the entomopathogenic fungus Metarhizium anisopliae. Photochem Photobiol 82:418–422",{"doi":1173},"10.1562\u002F2005-05-08-RA-52",{"id":18,"text":1175,"url":18,"identifiers":1176},"Braga GUL, Rangel DEN, Fernandes EKK, Flint SD, Roberts DW (2015) Molecular and physiological effects of environmental UV radiation on fungal conidia. Curr Genet. doi: 10.1007\u002Fs00294-015-0483-0",{},{"id":18,"text":1178,"url":18,"identifiers":1179},"Brown SM, Campbell LT, Lodge JK (2007) Cryptococcus neoformans, a fungus under stress. Curr Opin Microbiol 10:320–325. doi: 10.1016\u002Fj.mib.2007.05.014",{"doi":1180},"10.1016\u002Fj.mib.2007.05.014",{"id":18,"text":1182,"url":18,"identifiers":1183},"Brown AJP, Brown GD, Netea MG, Gow NAR (2014) Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels. Trends Microbiol 22:614–622. doi: 10.1016\u002Fj.tim.2014.07.001",{"doi":1184},"10.1016\u002Fj.tim.2014.07.001",{"id":18,"text":1186,"url":18,"identifiers":1187},"Cliquet S, Despreaux J, Zeeshan K, Ddl Broise, Ash G (2011) Characterization of aggregates produced by the potential mycoherbistat Plectosporium alismatis in submerged culture: germination UV-radiation tolerance and infectivity. Biocontrol Sci Technol 21:1243–1256. doi: 10.1080\u002F09583157.2011.604124",{"doi":1188},"10.1080\u002F09583157.2011.604124",{"id":18,"text":1190,"url":18,"identifiers":1191},"Costa LB, Rangel DEN, Morandi MAB, Bettiol W (2013) Effects of UV-B radiation on the antagonistic ability of Clonostachys rosea to Botrytis cinerea on strawberry leaves. Biol Control 65:95–100. doi: 10.1016\u002Fj.biocontrol.2012.12.007",{"doi":1192},"10.1016\u002Fj.biocontrol.2012.12.007",{"id":18,"text":1194,"url":18,"identifiers":1195},"Coutinho C, Bernardes E, Felix D, Panek AD (1988) Trehalose as cryoprotectant for preservation of yeast strains. J Biotechnol 7:23–32. doi: 10.1016\u002F0168-1656(88)90032-6",{"doi":1196},"10.1016\u002F0168-1656(88)90032-6",{"id":18,"text":1198,"url":18,"identifiers":1199},"Cray JA, Houghton JDR, Cooke LR, Hallsworth JE (2015a) A simple inhibition coefficient for quantifying potency of biocontrol agents against plant-pathogenic fungi Biol Control 81:93–100. doi: 10.1016\u002Fj.biocontrol.2014.11.006",{},{"id":18,"text":1201,"url":18,"identifiers":1202},"Cray JA, Stevenson A, Ball P, Bankar SB, Eleutherio ECA, Ezeji TC, Singhal RS, Thevelein JM, Timson DJ, Hallsworth JE (2015b) Chaotropicity: a key factor in product tolerance of biofuel-producing microorganisms Curr Opin. Biotech 33:228–259. doi: 10.1016\u002Fj.copbio.2015.02.010",{},{"id":18,"text":1204,"url":18,"identifiers":1205},"Dadachova E, Casadevall A (2008) Ionizing radiation: how fungi cope, adapt, and exploit with the help of melanin. Curr Opin Microbiol 11:525–531. doi: 10.1016\u002Fj.mib.2008.09.013",{"doi":1206},"10.1016\u002Fj.mib.2008.09.013",{"id":18,"text":1208,"url":18,"identifiers":1209},"Daoust RA, Roberts DW (1982) Virulence of natural and insect-passaged strains of Metarhizium anisopliae to mosquito larvae. J Invertebr Pathol 40:107–117",{"doi":1210},"10.1016\u002F0022-2011(82)90042-8",{"id":18,"text":1212,"url":18,"identifiers":1213},"Daoust RA, Roberts DW (1983a) Studies on the prolonged storage of Metarhizium anisopliae conidia: effect of growth substrate on conidial survival and virulence against mosquitoes. J Invertebrate Pathol 41:161–170",{"doi":1214},"10.1016\u002F0022-2011(83)90215-X",{"id":18,"text":1216,"url":18,"identifiers":1217},"Daoust RA, Roberts DW (1983b) Studies on the prolonged storage of Metarhizium anisopliae conidia: effect of temperature and relative humidity on conidial viability and virulence against mosquitoes. J Invertebr Pathol 41:143–150",{"doi":1218},"10.1016\u002F0022-2011(83)90213-6",{"id":18,"text":1220,"url":18,"identifiers":1221},"Dighton J, Tugay T, Zhdanova N (2008) Fungi and ionizing radiation from radionuclides. FEMS Microbiol Lett 281:109–120. doi: 10.1111\u002Fj.1574-6968.2008.01076.x",{"doi":1222},"10.1111\u002Fj.1574-6968.2008.01076.x",{"id":18,"text":1224,"url":18,"identifiers":1225},"Druzhinina IS, Seidl-Seiboth V, Herrera-Estrella A, Horwitz BA, Kenerley CM, Monte E, Mukherjee PK, Zeilinger S, Grigoriev IV, Kubicek CP (2011) Trichoderma: the genomics of opportunistic success. Nat Rev Microbiol 9:749–759. doi: 10.1038\u002Fnrmicro2637",{"doi":1226},"10.1038\u002Fnrmicro2637",{"id":18,"text":1228,"url":18,"identifiers":1229},"Eleutherio EC, Araujo PS, Panek AD (1993a) Role of the trehalose carrier in dehydration resistance of Saccharomyces cerevisiae. Biochim Biophys Acta 1156:263–266",{"doi":1230},"10.1016\u002F0304-4165(93)90040-F",{"id":18,"text":1232,"url":18,"identifiers":1233},"Eleutherio ECA, Araujo PS, Panek AD (1993b) Protective role of trehalose during heat stress in Saccharomyces cerevisiae. Cryobiology 30:591–596. doi: 10.1006\u002Fcryo.1993.1061",{"doi":1234},"10.1006\u002Fcryo.1993.1061",{"id":18,"text":1236,"url":18,"identifiers":1237},"Eleutherio E, Panek AD, de Mesquita JF, Trevisol E, Magalhães R (2014) Revisiting yeast trehalose metabolism. Curr Genet doi: 10.1007\u002Fs00294-014-0450-1",{"doi":1238},"10.1007\u002Fs00294-014-0450-1",{"id":18,"text":1240,"url":18,"identifiers":1241},"Ene IV, Brunke S, Brown AJP, Hube B (2014) Metabolism in fungal pathogenesis cold spring harb. Perspect Med doi: 10.1101\u002Fcshperspect.a019695",{"doi":1242},"10.1101\u002Fcshperspect.a019695",{"id":18,"text":1244,"url":18,"identifiers":1245},"Faria MR, Wraight SP (2007) Mycoinsecticides and mycoacaricides: a comprehensive list with worldwide coverage and international classification of formulation types. Biol Control 43:237–256",{"doi":1246},"10.1016\u002Fj.biocontrol.2007.08.001",{"id":18,"text":1248,"url":18,"identifiers":1249},"Fernandes EKK, Rangel DEN, Moraes AM, Bittencourt VR, Roberts DW (2007) Variability in tolerance to UV-B radiation among Beauveria spp. isolates. J Invertebr Pathol 96:237–243",{"doi":1250},"10.1016\u002Fj.jip.2007.05.007",{"id":18,"text":1252,"url":18,"identifiers":1253},"Fernandes EKK, Rangel DEN, Moraes AML, Bittencourt VREP, Roberts DW (2008) Cold activity of Beauveria and Metarhizium, and thermotolerance of Beauveria. J Invertebr Pathol 98:69–78",{"doi":1254},"10.1016\u002Fj.jip.2007.10.011",{"id":18,"text":1256,"url":18,"identifiers":1257},"Fernandes EKK, Moraes AML, Pacheco RS, Rangel DEN, Miller MP, Bittencourt VREP, Roberts DW (2009) Genetic diversity among Brazilian isolates of Beauveria bassiana: comparisons with non-Brazilian isolates and other Beauveria species. J Appl Microbiol 107:760–774",{"doi":1258},"10.1111\u002Fj.1365-2672.2009.04258.x",{"id":18,"text":1260,"url":18,"identifiers":1261},"Fernandes EKK, Keyser CA, Chong JP, Rangel DEN, Miller MP, Roberts DW (2010a) Characterization of Metarhizium species and varieties based on molecular analysis, heat tolerance and cold activity. J Appl Microbiol 108:115–128",{"doi":1262},"10.1111\u002Fj.1365-2672.2009.04422.x",{"id":18,"text":1264,"url":18,"identifiers":1265},"Fernandes EKK, Keyser CA, Rangel DEN, Foster RN, Roberts DW (2010b) CTC medium: a novel dodine-free selective medium for isolating entomopathogenic fungi, especially Metarhizium acridum, from soil. Biol Control 54:197–205. doi: 10.1016\u002Fj.biocontrol.2010.05.009",{"doi":1266},"10.1016\u002Fj.biocontrol.2010.05.009",{"id":18,"text":1268,"url":18,"identifiers":1269},"Fernandes EKK, Angelo IC, Rangel DEN, Bahiense TC, Moraes AM, Roberts DW, Bittencourt VR (2011) An intensive search for promising fungal biological control agents of ticks, particularly Rhipicephalus microplus. Vet Parasitol 182:307–318. doi: 10.1016\u002Fj.vetpar.2011.05.046",{"doi":1270},"10.1016\u002Fj.vetpar.2011.05.046",{"id":18,"text":1272,"url":18,"identifiers":1273},"Fernandes EKK, Rangel DEN, Braga GUL, Roberts DW (2015) Tolerance of entomopathogenic fungi to ultraviolet radiation: a review on screening of strains and their formulation. Curr Genet",{"doi":1274},"10.1007\u002Fs00294-015-0492-z",{"id":18,"text":1276,"url":18,"identifiers":1277},"Finlay RD (2008) Ecological aspects of mycorrhizal symbiosis: with special emphasis on the functional diversity of interactions involving the extraradical mycelium. J Exp Bot 59:1115–1126. doi: 10.1093\u002Fjxb\u002Fern059",{"doi":1278},"10.1093\u002Fjxb\u002Fern059",{"id":18,"text":1280,"url":18,"identifiers":1281},"Finlay R, Wallander H, Smits M, Holmstrom S, van Hees P, Lian B, Rosling A (2009) The role of fungi in biogenic weathering in boreal forest soils. Fungal Biol Rev 23:101–106. doi: 10.1016\u002Fj.fbr.2010.03.002",{"doi":1282},"10.1016\u002Fj.fbr.2010.03.002",{"id":18,"text":1284,"url":18,"identifiers":1285},"Fuller K, Loros J, Dunlap J (2014) Fungal photobiology: visible light as a signal for stress, space and time. Curr Genet. doi: 10.1007\u002Fs00294-014-0451-0",{"doi":1286},"10.1007\u002Fs00294-014-0451-0",{"id":18,"text":1288,"url":18,"identifiers":1289},"Gadd GM (2010) Metals, minerals and microbes: geomicrobiology and bioremediation. Microbiology 156:609–643. doi: 10.1099\u002Fmic.0.037143-0",{"doi":1290},"10.1099\u002Fmic.0.037143-0",{"id":18,"text":1292,"url":18,"identifiers":1293},"Hagedorn S, Kaphammer B (1994) Microbial biocatalysis in the generation of flavor and fragrance chemicals. Annu Rev Microbiol 48:773–800. doi: 10.1146\u002Fannurev.mi.48.100194.004013",{"doi":1294},"10.1146\u002Fannurev.mi.48.100194.004013",{"id":18,"text":1296,"url":18,"identifiers":1297},"Hallsworth JE, Magan N (1996) Culture age, temperature, and pH affect the polyol and trehalose contents of fungal propagules. Appl Environ Microbiol 62:2435–2442",{"doi":1298},"10.1128\u002FAEM.62.7.2435-2442.1996",{"id":18,"text":1300,"url":18,"identifiers":1301},"Hallsworth JE, Prior BA, Nomura Y, Iwahara M, Timmis KN (2003) Compatible solutes protect against chaotrope (ethanol)-induced, nonosmotic water stress. Appl Environ Microb 69:7032–7034. doi: 10.1128\u002Faem.69.12.7032-7034.2003",{"doi":1302},"10.1128\u002FAEM.69.12.7032-7034.2003",{"id":18,"text":1304,"url":18,"identifiers":1305},"Herdeiro RS, Pereira MD, Panek AD, Eleutherio ECA (2006) Trehalose protects Saccharomyces cerevisiae from lipid peroxidation during oxidative stress. Biochim Biophys Acta Gen Subjects 1760:340–346. doi: 10.1016\u002Fj.bbagen.2006.01.010",{"doi":1306},"10.1016\u002Fj.bbagen.2006.01.010",{"id":18,"text":1308,"url":18,"identifiers":1309},"Hernández-Oñate MA, Herrera-Estrella A (2015) Damage response involves mechanisms conserved across plants, animals and fungi. Curr Genet. doi: 10.1007\u002Fs00294-014-0467-5",{"doi":1310},"10.1007\u002Fs00294-014-0467-5",{"id":18,"text":1312,"url":18,"identifiers":1313},"Hillmann F, Shekhova E, Kniemeyer O (2015) Insights into the cellular responses to hypoxia in filamentous fungi Curr Genet",{"doi":1314},"10.1007\u002Fs00294-015-0487-9",{"id":18,"text":1316,"url":18,"identifiers":1317},"Hohmann S (2015) An integrated view on a eukaryotic osmoregulation system. Curr Genet doi: 10.1007\u002Fs00294-015-0475-0",{"doi":1318},"10.1007\u002Fs00294-015-0475-0",{"id":18,"text":1320,"url":18,"identifiers":1321},"Huarte-Bonnet C, Juárez MP, Pedrini N (2014) Oxidative stress in entomopathogenic fungi grown on insect-like hydrocarbons. Curr Genet doi: 10.1007\u002Fs00294-014-0452-z",{"doi":1322},"10.1007\u002Fs00294-014-0452-z",{"id":18,"text":1324,"url":18,"identifiers":1325},"Kaijiang L, Roberts DW (1986) The production of destruxins by the entomogenous fungus, Metarhizium anisopliae var. major. J Invertebr Pathol 47:120–122. doi: 10.1016\u002F0022-2011(86)90170-9",{"doi":1326},"10.1016\u002F0022-2011(86)90170-9",{"id":18,"text":1328,"url":18,"identifiers":1329},"Keyser CA, Fernandes EKK, Rangel DEN, Roberts DW (2014) Heat-induced post-stress growth delay: A biological trait of many Metarhizium isolates reducing biocontrol efficacy? J Invertebr Pathol 120:67–73. doi: 10.1016\u002Fj.jip.2014.05.008",{"doi":1330},"10.1016\u002Fj.jip.2014.05.008",{"id":18,"text":1332,"url":18,"identifiers":1333},"Li ZZ, Alves SB, Roberts DW, Fan MZ, Delalibera I, Tang J, Lopes RB, Faria M, Rangel DEN (2010) Biological control of insects in Brazil and China: history, current programs and reasons for their successes using entomopathogenic fungi. Biocontrol Sci Tech 20:117–136",{"doi":1334},"10.1080\u002F09583150903431665",{"id":18,"text":1336,"url":18,"identifiers":1337},"Lovett B, St. Leger R (2014) Stress is the rule rather than the exception for Metarhizium. Curr Genet doi: 10.1007\u002Fs00294-014-0447-9",{"doi":1338},"10.1007\u002Fs00294-014-0447-9",{"id":18,"text":1340,"url":18,"identifiers":1341},"Mansure JJC, Panek AD, Crowe LM, Crowe JH (1994) Trehalose inhibits ethanol effects on intact yeast cells and liposomes. Biochimica Et Biophysica Acta Biomembranes 1191:309–316. doi: 10.1016\u002F0005-2736(94)90181-3",{"doi":1342},"10.1016\u002F0005-2736(94)90181-3",{"id":18,"text":1344,"url":18,"identifiers":1345},"McCarthy WJ, Granados RR, Sutter GR, Roberts DW (1975) Characterization of entomopox virions of the army cutworm, Euxoa auxiliaris (Lepidoptera: Noctuidae). J Invertebr Pathol 25:215–220. doi: 10.1016\u002F0022-2011(75)90071-3",{"doi":1346},"10.1016\u002F0022-2011(75)90071-3",{"id":18,"text":1348,"url":18,"identifiers":1349},"Medina A, Schmidt-Heydt M, Rodríguez A, Parra R, Geisen R, Magan N (2014) Impacts of environmental stress on growth, secondary metabolite biosynthetic gene clusters and metabolite production of xerotolerant\u002Fxerophilic fungi. Curr Genet doi: 10.1007\u002Fs00294-014-0455-9",{"doi":1350},"10.1007\u002Fs00294-014-0455-9",{"id":18,"text":1352,"url":18,"identifiers":1353},"Ortiz CH, Maia JC, Tenan MN, Braz-Padrao GR, Mattoon JR, Panek AD (1983) Regulation of yeast trehalase by a monocyclic, cyclic AMP-dependent phosphorylation-dephosphorylation cascade system. J Bacteriol 153:644–651",{"doi":1354},"10.1128\u002FJB.153.2.644-651.1983",{"id":18,"text":1356,"url":18,"identifiers":1357},"Ortiz-Urquiza A, Keyhani NO (2014) Stress response signaling and virulence: insights from entomopathogenic fungi. Curr Genet doi: 10.1007\u002Fs00294-014-0439-9",{"doi":1358},"10.1007\u002Fs00294-014-0439-9",{"id":18,"text":1360,"url":18,"identifiers":1361},"Panek A (1959) Kinetic study of the formation and the utilization of trehalose by baker’s yeast. C R Hebd Seances Acad Sci 249:333–335",{},{"id":18,"text":1363,"url":18,"identifiers":1364},"Panek A (1962) Synthesis of trehalose by baker’s yeast (Saccharomyces cerevisiae). Arch Biochem Biophys 98:349–355",{"doi":1365},"10.1016\u002F0003-9861(62)90197-2",{"id":18,"text":1367,"url":18,"identifiers":1368},"Panek A (1963) Function of trehalose in baker’s yeast (Saccharomyces cerevisiae). Arch Biochem Biophys 100:422–425",{"doi":1369},"10.1016\u002F0003-9861(63)90107-3",{"id":18,"text":1371,"url":18,"identifiers":1372},"Pointing SB (2001) Feasibility of bioremediation by white-rot fungi. Appl Microbiol Biotechnol 57:20–33",{"doi":1373},"10.1007\u002Fs002530100745",{"id":18,"text":1375,"url":18,"identifiers":1376},"Rangel DEN (2011) Stress induced cross-protection against environmental challenges on prokaryotic and eukaryotic microbes. World J Microb Biot 27:1281–1296. doi: 10.1007\u002Fs11274-010-0584-3",{"doi":1377},"10.1007\u002Fs11274-010-0584-3",{"id":18,"text":1379,"url":18,"identifiers":1380},"Rangel DEN, Correia AdCB (2003) Virulencia de Aphanocladium album (Preuss) Gams e Verticillium lecanii (Zimm.) Viégas (Deuteromycotina: Hyphomycetes) para o percevejo-de-renda da seringueira, Leptopharsa heveae (Drake & Poor) (Hemiptera: Tingidae) Ciência e Agrotecnologia Edicao Especial:1636–1642",{},{"id":18,"text":1382,"url":18,"identifiers":1383},"Rangel DEN, Braga GUL, Anderson AJ, Roberts DW (2005) Variability in conidial thermotolerance of Metarhizium anisopliae isolates from different geographic origins. J Invertebr Pathol 88:116–125",{"doi":1384},"10.1016\u002Fj.jip.2004.11.007",{"id":18,"text":1386,"url":18,"identifiers":1387},"Rangel DEN, Anderson AJ, Roberts DW (2006) Growth of Metarhizium anisopliae on non-preferred carbon sources yields conidia with increased UV-B tolerance. J Invertebr Pathol 93:127–134",{"doi":1388},"10.1016\u002Fj.jip.2006.05.011",{"id":18,"text":1390,"url":18,"identifiers":1391},"Rangel DEN, Alston DG, Roberts DW (2008a) Effects of physical and nutritional stress conditions during mycelial growth on conidial germination speed, adhesion to host cuticle, and virulence of Metarhizium anisopliae, an entomopathogenic fungus. Mycol Res 112:1355–1361",{"doi":1392},"10.1016\u002Fj.mycres.2008.04.011",{"id":18,"text":1394,"url":18,"identifiers":1395},"Rangel DEN, Anderson AJ, Roberts DW (2008b) Evaluating physical and nutritional stress during mycelial growth as inducers of tolerance to heat and UV-B radiation in Metarhizium anisopliae conidia. Mycol Res 112:1362–1372",{"doi":1396},"10.1016\u002Fj.mycres.2008.04.013",{"id":18,"text":1398,"url":18,"identifiers":1399},"Rangel DEN, Dettenmaier SJ, Fernandes EKK, Roberts DW (2010a) Susceptibility of Metarhizium spp. and other entomopathogenic fungi to dodine-based selective media. Biocontrol Sci Tech 20:375–389",{"doi":1400},"10.1080\u002F09583150903518370",{"id":18,"text":1402,"url":18,"identifiers":1403},"Rangel DEN, Fernandes EKK, Dettenmaier SJ, Roberts DW (2010b) Thermotolerance of germlings and mycelium of the insect-pathogenic fungus Metarhizium spp. and mycelial recovery after heat stress. J Basic Microb 50:344–350",{"doi":1404},"10.1002\u002Fjobm.200900430",{"id":18,"text":1406,"url":18,"identifiers":1407},"Rangel DEN, Fernandes EKK, Braga GUL, Roberts DW (2011) Visible light during mycelial growth and conidiation of Metarhizium robertsii produces conidia with increased stress tolerance. FEMS Microbiol Lett 315:81–86. doi: 10.1111\u002Fj.1574-6968.2010.02168.x",{"doi":1408},"10.1111\u002Fj.1574-6968.2010.02168.x",{"id":18,"text":1410,"url":18,"identifiers":1411},"Rangel DEN, Fernandes EKK, Anderson AJ, Roberts DW (2012) Culture of Metarhizium robertsii on salicylic-acid supplemented medium induces increased conidial thermotolerance Fungal Biol-Uk 116:438–442",{},{"id":18,"text":1413,"url":18,"identifiers":1414},"Rangel DEN, Alder-Rangel A, Dadachova E, Finlay RD, Kupiec M, Dijksterhuis J, Braga GUL, Corrochano LM, Hallsworth JE (2015a) Fungal stress biology: a preface to the   Fungal Stress Responses special edition. Curr Genet. doi: 10.1007\u002Fs00294-015-0500-3",{},{"id":18,"text":1416,"url":18,"identifiers":1417},"Rangel DEN, Braga GUL, Fernandes EKK, Keyser CA, Hallsworth JE, Roberts DW (2015b) Stress tolerance and virulence of insect-pathogenic fungi are determined by environmental conditions during conidial formation. Curr Genet doi: 10.1007\u002Fs00294-015-0477-y",{"doi":1418},"10.1007\u002Fs00294-015-0477-y",{"id":18,"text":1420,"url":18,"identifiers":1421},"Roberts DW (1966) Toxins from the entomogenous fungus Metarrhizium anisopliae I Production in submerged and surface cultures, and in inorganic and organic nitrogen media. J Invertebr Pathol 8:212–221",{"doi":1422},"10.1016\u002F0022-2011(66)90131-5",{"id":18,"text":1424,"url":18,"identifiers":1425},"Roberts DW (1969) Toxins from the entomogenous fungus Metarrhizium anisopliae: Isolation of destruxins from submerged cultures. J Invertebr Pathol 14:82–88. doi: 10.1016\u002F0022-2011(69)90012-3",{"doi":1426},"10.1016\u002F0022-2011(69)90012-3",{"id":18,"text":1428,"url":18,"identifiers":1429},"Roberts DW, St. Leger RJ (2004) Metarhizium spp., cosmopolitan insect-pathogenic fungi: mycological aspects. Adv Appl Microbiol 54:1–70",{"doi":1430},"10.1016\u002FS0065-2164(04)54001-7",{"id":18,"text":1432,"url":18,"identifiers":1433},"Roberts DW, LeBrun RA, Semel M (1981) Control of the colorado potato beetle with fungi. In: Casagrande RaJL (ed) Advances in potato pest management. Hutchinson and Ross Publ. Co., Stroudsberg, pp 119–137",{},{"id":18,"text":1435,"url":18,"identifiers":1436},"Roberts DW, Rangel DEN, Keyser CA, Bignayan HG, Dettenmaier SJ, Fernandes EKK, Miller MP, Evans EW (2007) The mormon cricket, an old threat in modern day western USA: a search for fungal pathogens. J Anhui Agricul Univ 34:141–148",{},{"id":18,"text":1438,"url":18,"identifiers":1439},"Santi L, Beys da Silva WO, Berger M, Guimaraes JA, Schrank A, Vainstein MH (2010) Conidial surface proteins of Metarhizium anisopliae: Source of activities related with toxic effects, host penetration and pathogenesis Toxicon 55:874-880 doi: 10.1016\u002Fj.toxicon.2009.12.012",{"doi":1440},"10.1016\u002Fj.toxicon.2009.12.012",{"id":18,"text":1442,"url":18,"identifiers":1443},"Santos MP, Dias LP, Ferreira PC, Pasin LA, Rangel DEN (2011) Cold activity and tolerance of the entomopathogenic fungus Tolypocladium spp. to UV-B irradiation and heat. J Invertebr Pathol 108:209–213. doi: 10.1016\u002Fj.jip.2011.09.001",{"doi":1444},"10.1016\u002Fj.jip.2011.09.001",{"id":18,"text":1446,"url":18,"identifiers":1447},"Santos R, Stevenson A, de Carvalho CCCR, Grant IR, Hallsworth JE (2015) Extraordinary solute-stress tolerance contributes to the environmental tenacity of mycobacteria. Environ Microbiol Rep. doi: 10.1111\u002F1758-2229.12306",{},{"id":18,"text":1449,"url":18,"identifiers":1450},"Schwan RF, Wheals AE (2004) The microbiology of cocoa fermentation and its role in chocolate quality. Crit Rev Food Sci Nutr 44:205–221. doi: 10.1080\u002F10408690490464104",{"doi":1451},"10.1080\u002F10408690490464104",{"id":18,"text":1453,"url":18,"identifiers":1454},"Selbmann L, Zucconi L, Isola D, Onofri S (2014) Rock black fungi: excellence in the extremes, from the Antarctic to space. Curr Genet doi: 10.1007\u002Fs00294-014-0457-7",{"doi":1455},"10.1007\u002Fs00294-014-0457-7",{"id":18,"text":1457,"url":18,"identifiers":1458},"Shalaby S, Horwitz BA (2014) Plant phenolic compounds and oxidative stress: integrated signals in fungal–plant interactions. Curr Genet doi: 10.1007\u002Fs00294-014-0458-6",{"doi":1459},"10.1007\u002Fs00294-014-0458-6",{"id":18,"text":1461,"url":18,"identifiers":1462},"Singh SK, Pandey A (2013) Emerging approaches in fermentative production of statins. Appl Biochem Biotechnol 171:927–938. doi: 10.1007\u002Fs12010-013-0400-2",{"doi":1463},"10.1007\u002Fs12010-013-0400-2",{"id":18,"text":1465,"url":18,"identifiers":1466},"Solé C, Nadal-Ribelles M, de Nadal E, Posas F (2014) A novel role for lncRNAs in cell cycle control during stress adaptation. Curr Genet doi: 10.1007\u002Fs00294-014-0453-y",{"doi":1467},"10.1007\u002Fs00294-014-0453-y",{"id":18,"text":1469,"url":18,"identifiers":1470},"Souza RKF, Azevedo RFF, Lobo AO, Rangel DEN (2014) Conidial water affinity is an important characteristic for thermotolerance in entomopathogenic fungi. Biocontrol Sci Tech 24:448–461. doi: 10.1080\u002F09583157.2013.871223",{"doi":1471},"10.1080\u002F09583157.2013.871223",{"id":18,"text":1473,"url":18,"identifiers":1474},"St. Leger R, Joshi L, Bidochka MJ, Roberts DW (1996) Construction of an improved mycoinsecticide overexpressing a toxic protease. Proc Natl Acad Sci U S A 93:6349–6354",{"doi":1475},"10.1073\u002Fpnas.93.13.6349",{"id":18,"text":1477,"url":18,"identifiers":1478},"St. Leger RJ, Goettel M, Roberts DW, Staples RC (1991) Prepenetration events during infection of host cuticle by Metarhizium anisopliae. J Invertebr Pathol 58:168–179",{"doi":1479},"10.1016\u002F0022-2011(91)90061-T",{"id":18,"text":1481,"url":18,"identifiers":1482},"St. Leger RJ, Joshi L, Roberts D (1998) Ambient pH is a major determinant in the expression of cuticle-degrading enzymes and hydrophobin by Metarhizium anisopliae. Appl Environ Microbiol 64:709–713",{"doi":1483},"10.1128\u002FAEM.64.2.709-713.1998",{"id":18,"text":1485,"url":18,"identifiers":1486},"St. Leger RJ, Nelson JO, Screen SE (1999) The entomopathogenic fungus Metarhizium anisopliae alters ambient pH, allowing extracellular protease production and activity. Microbiology 145:2691–2699",{"doi":1487},"10.1099\u002F00221287-145-10-2691",{"id":18,"text":1489,"url":18,"identifiers":1490},"St. Leger RJ (2010) Society for Invertebrate Pathology 2009 Founders’ Lecture Donald W. Roberts-50 Years of leadership in insect pathology. J Invertebr Pathol 105:211–219. doi: 10.1016\u002Fj.jip.2010.09.021",{"doi":1491},"10.1016\u002Fj.jip.2010.09.021",{"id":18,"text":1493,"url":18,"identifiers":1494},"Stevenson A, Cray JA, Williams JP, Santos R, Sahay R, Neuenkirchen N, McClure CD, Grant IR, Houghton JDR, Quinn JP, Timson DJ, Patil SV, Singhal RS, Anton J, Dijksterhuis J, Hocking AD, Lievens B, Rangel DEN, Voytek MA, Gunde-Cimerman N, Oren A, Timmis KN, McGenity TJ, Hallsworth JE (2015) Is there a common water-activity limit for the three domains of life? ISME J. doi: 10.1038\u002Fismej.2014.219",{},{"id":18,"text":1496,"url":18,"identifiers":1497},"Zhao XQ, Bai FW (2009) Mechanisms of yeast stress tolerance and its manipulation for efficient fuel ethanol production. J Biotechnol 144:23–30. doi: 10.1016\u002Fj.jbiotec.2009.05.001",{"doi":1498},"10.1016\u002Fj.jbiotec.2009.05.001",{"id":18,"text":1500,"url":18,"identifiers":1501},"Zhdanova NN, Zakharchenko VA, Vember VV, Nakonechnaya LT (2000) Fungi from Chernobyl: micobiota of the inner regions of the containment structures of the damaged nuclear reactor. Mycol Res 104:1421–1426",{"doi":1502},"10.1017\u002FS0953756200002756",{"id":1504,"createTime":1505,"updateTime":1505,"relativeEntities":1506,"slug":1507,"properties":1508,"entityType":126,"verifyStatus":127,"verifyTime":1505,"verifyNote":128,"syncStatus":17,"languages":1523,"translateLanguages":18,"viewCount":19,"primaryUrl":1524,"fullTextUrl":18,"authors":1525,"publicationType":216,"publisherRelationship":1562,"citationCount":1597,"citationInfo":1598,"publishDate":1600,"publishYear":1601,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":1602,"isForceReanalyzing":252},"8b641072-c27d-40bd-8602-fbfb9c36e1d7","2024-12-25T23:56:05.401+00:00",[],"Role-of-SGS1-and-SLX4-in-maintaining-rDNA-structure-in-Saccharomyces-cerevisiae",{"mag":1509,"keywords":1511,"pmc":1512,"openalex":1514,"abstract":1516,"title":1517,"pm":1519,"doi":1521},{"VOID":1510},"2095557596",{},{"VOID":1513},"2804045",{"VOID":1515},"W2095557596",{},{"EN":1518},"Role of SGS1 and SLX4 in maintaining rDNA structure in Saccharomyces cerevisiae",{"VOID":1520},"12228808",{"VOID":1522},"10.1007\u002Fs00294-002-0319-6",[919],"http:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs00294-002-0319-6",[1526,1547],{"id":1527,"sortIndex":19,"researcher":18,"roles":1528,"affiliations":1529,"properties":1540},"a2bf2dcc-1a30-4b06-bca0-1cc838704782",[],[1530],{"id":1531,"sortIndex":19,"affiliation":1532,"properties":18},"00be0fca-b390-4234-8ef2-448cbbf93d87",{"id":1533,"createTime":1534,"updateTime":1534,"relativeEntities":1535,"slug":1536,"properties":1537,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"8c63e747-1582-4a42-a9b1-070268af0f5d","2024-12-25T23:56:05.429+00:00",[],"Department-of-Molecular-Biology-and-Biochemistry-679-Hoes-Lane-CABM-Rutgers-University-Piscataway-NJ-08854-USA-",{"title":1538},{"EN":1539},"Department of Molecular Biology and Biochemistry, 679 Hoes Lane, CABM, Rutgers University, Piscataway, NJ 08854, USA.",{"openalex":1541,"orcid":1543,"title":1545},{"VOID":1542},"A5085865686",{"VOID":1544},"https:\u002F\u002Forcid.org\u002F0000-0002-6803-4341",{"EN":1546},"Vivek Kaliraman",{"id":1548,"sortIndex":102,"researcher":18,"roles":1549,"affiliations":1550,"properties":1557},"7cd88b9b-caf1-4d1f-954d-290157d30a6d",[],[1551],{"id":1552,"sortIndex":19,"affiliation":1553,"properties":18},"ee872ec9-c0a4-4f5e-abcf-389479dbe32b",{"id":1533,"createTime":1534,"updateTime":1534,"relativeEntities":1554,"slug":1536,"properties":1555,"entityType":47,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1556},{"EN":1539},{"openalex":1558,"title":1560},{"VOID":1559},"A5108447561",{"EN":1561},"Steven J. Brill",{"url":18,"publisher":1563,"properties":1590},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1564,"slug":10,"properties":1565,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1568,"manageAffiliations":1569,"indexDatabases":1570,"url":18,"thumbnailPath":18,"statistic":1585,"gsStatistic":18,"type":106,"analyzePriority":18},[],{"issn":1566,"title":1567},{"VOID":13},{"VOID":15},[],[],[1571,1578],{"id":82,"indexDatabase":1572,"url":97,"indexYears":18,"academicFieldIds":1577,"indexDatabaseRanking":18},{"id":84,"createTime":85,"updateTime":86,"relativeEntities":1573,"label":1574,"description":1575,"key":93,"publicationTags":1576,"standard":18},[],{"EN":89,"VI":89},{"VI":91,"EN":92},[95,96],[99],{"id":62,"indexDatabase":1579,"url":75,"indexYears":76,"academicFieldIds":1584,"indexDatabaseRanking":80},{"id":64,"createTime":65,"updateTime":66,"relativeEntities":1580,"label":1581,"description":1582,"key":72,"publicationTags":1583,"standard":18},[],{"EN":69,"VI":69},{"EN":69,"VI":71},[74],[78,79],{"impactFactor":19,"impactFactorByYear":1586,"i10Index":19,"i10IndexLast5Year":19,"totalPublication":102,"totalPublicationByYear":1587,"totalCitation":19,"totalCitationByYear":1588,"totalCitationPerPublication":19,"totalCitationPerPublicationByYear":1589,"hindexLast5Year":19,"hindex":19},{},{"2003":102},{},{},{"volume":1591,"pages":1593,"issue":1595},{"VOID":1592},"41",{"VOID":1594},"389-400",{"VOID":1596},"6",64,{"total":1597,"publishYear":18,"statisticByYear":1599},{"2012":133,"2013":180,"2014":150,"2015":133,"2016":205,"2017":180,"2018":102,"2019":180,"2020":102,"2023":102,"2024":102},"2002-09-01",2002,[]]