[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"\"}":3,"_public_publisher_byId_d6c0257a-ce65-4515-865e-d8b69b4dae86":865,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"totalCitation\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:d6c0257a-ce65-4515-865e-d8b69b4dae86,\"}":924},{"meta":4,"data":6},{"total":5},"117",[7,56,246,295,379,474,535,646,710,744],{"id":8,"createTime":9,"updateTime":10,"relativeEntities":11,"slug":12,"properties":13,"entityType":25,"verifyStatus":26,"verifyTime":27,"verifyNote":28,"languages":29,"translateLanguages":28,"viewCount":32,"subjectFields":33,"manageAffiliations":34,"indexDatabases":35,"url":36,"thumbnailPath":28,"statistic":28,"gsStatistic":37,"type":55,"analyzePriority":28},"f8d0bf97-8d89-482e-b58c-2fc481a0b79b","2025-10-27T06:27:08.591+00:00","2026-08-27T01:57:29.562+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Khoa-h%E1%BB%8Dc-v%C3%A0-C%C3%B4ng-ngh%E1%BB%87-nhi%E1%BB%87t-%C4%91%E1%BB%9Bi",{"country":14,"issn":16,"title":18,"introduce":21,"gsId":23},{"VOID":15},"VN",{"VOID":17},"08667535",{"EN":19,"VI":20},"Journal of Tropical Science and Engineering","Tạp chí Khoa học và Công nghệ nhiệt đới",{"EN":22},"\u003Cp style=\"text-align:justify;\">     Journal of Tropical Science and Engineering (JTSE) is a multidisciplinary scientific journal, licensed to operate as a print journal in 2012 and an electronic journal in 2024 (License No.1479\u002FGP-BTTTT dated August 20, 2012 and No.91\u002FGP-BTTTT dated April 9, 2024 issued by the Ministry of Information and Communications of Vietnam). The JTSE is headquartered in Hanoi.\u003C\u002Fp>\u003Cp style=\"text-align:justify;\">        The JTSE is published every 3 months (4 issues\u002Fyear), publishing research results and overview articles in 3 groups of fields: Tropical Ecology and Environment; Chemistry and Material Sciences; Biomedicine and Pharmacy. In 2022, the JTSE registered the international identifier Digital Object Identifier (DOI): 10.58334\u002Fvrtc.jtst and assigned DOI codes to all articles of the journal. The members of the Editorial Board of the JTSE are prestigious scientists and leading scientists from Vietnam and many countries in the world. The JTSE has been recognized by the Vietnam State Council for Professorship to score scientific articles in Chemistry, Medicine and Biology with scores ranging from 0-0.75 points.\u003C\u002Fp>\u003Cp style=\"text-align:justify;\">      Currently, the JTSE is building and perfecting a set of criteria and making efforts to join the List of prestigious  international journals with a roadmap to enter Scopus and SCIE in the coming time.\u003C\u002Fp>",{"VOID":24},"MS2_GJQAAAAJ","PUBLISHER","VERIFIED","2025-10-27T06:27:25.058+00:00",null,[30,31],"VI","EN",0,[],[],[],"https:\u002F\u002Ftapchikhcnnd.com.vn",{"impactFactor":28,"impactFactorByYear":28,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":38,"totalPublicationByYear":39,"totalCitation":43,"totalCitationByYear":44,"totalCitationPerPublication":52,"totalCitationPerPublicationByYear":53,"hindexLast5Year":42,"hindex":42},483,{"0":40,"2020":40,"2021":40,"2022":40,"2024":40,"2025":41,"2026":42},1,475,3,117,{"2017":40,"2018":40,"2019":45,"2020":46,"2021":46,"2022":47,"2023":48,"2024":49,"2025":50,"2026":51},4,5,11,6,7,53,15,0.24,{"2020":46,"2021":46,"2022":47,"2024":49,"2025":54,"2026":46},0.11,"JOURNAL",{"id":57,"createTime":58,"updateTime":10,"relativeEntities":59,"slug":60,"properties":61,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":69,"subjectFields":70,"manageAffiliations":71,"indexDatabases":84,"url":101,"thumbnailPath":28,"statistic":102,"gsStatistic":195,"type":55,"analyzePriority":28},"cc3aedc1-bd17-441e-b403-4be82349b362","2023-05-29T12:05:16.902+00:00",[],"Vietnam-Journal-of-Mechanics",{"country":62,"issn":63,"title":65,"gsId":67},{"VOID":15},{"VOID":64},"08667136",{"EN":66},"Vietnam Journal of Mechanics",{"VOID":68},"B98qpzgAAAAJ",29,[],[72],{"id":73,"createTime":28,"updateTime":28,"relativeEntities":74,"slug":28,"properties":75,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":82,"parentIds":83,"statistic":28},"5bf72910-eb8d-41eb-b358-ea294f24f765",[],{"title":76,"country":79,"abbreviation":80},{"EN":77,"VI":78},"Vietnam Academy of Science and Technology","Viện Hàn lâm Khoa học và Công nghệ Việt Nam",{"VOID":15},{"VOID":81},"VAST","https:\u002F\u002Fvast.gov.vn\u002F",[],[85],{"id":86,"indexDatabase":87,"url":97,"indexYears":98,"academicFieldIds":99,"indexDatabaseRanking":28},"61d05d3d-1119-4247-9062-3944e6a8afd5",{"id":88,"createTime":28,"updateTime":28,"relativeEntities":89,"label":90,"description":92,"key":94,"publicationTags":95,"standard":28},"7c6668cf-5dbb-472f-ac65-0e3d0d95e1c2",[],{"EN":91,"VI":91},"ACI - Asean Citation Index",{"EN":93,"VI":93},"Cơ sở dữ liệu ACI","aci",[96],"ACI","https:\u002F\u002Fasean-cites.org\u002Fjournal_info?jid=10758","2018-2022",[100],"007635a4-2624-49b8-a8f3-fec188e6a80e","http:\u002F\u002Fvjs.ac.vn\u002Findex.php\u002Fvjmech\u002Findex",{"impactFactor":32,"impactFactorByYear":103,"i10Index":122,"i10IndexLast5Year":123,"totalPublication":124,"totalPublicationByYear":125,"totalCitation":143,"totalCitationByYear":144,"totalCitationPerPublication":163,"totalCitationPerPublicationByYear":164,"hindexLast5Year":146,"hindex":146},{"1994":104,"1995":105,"1997":54,"1998":106,"1999":105,"2000":107,"2001":108,"2002":107,"2003":107,"2004":109,"2005":110,"2006":111,"2007":105,"2008":110,"2010":112,"2011":113,"2012":114,"2013":115,"2014":105,"2015":116,"2016":111,"2017":116,"2018":117,"2019":109,"2020":118,"2021":119,"2022":115,"2023":120,"2024":121},0.12,0.08,0.05,0.02,0.1,0.15,0.14,0.09,0.07,0.21,0.73,0.52,0.13,0.26,0.36,0.61,0.64,0.27,23,2,1046,{"1979":126,"1980":127,"1981":128,"1982":129,"1983":51,"1984":129,"1985":130,"1986":128,"1987":51,"1988":51,"1989":122,"1990":128,"1991":129,"1992":128,"1993":131,"1994":132,"1995":133,"1996":133,"1997":132,"1998":131,"1999":128,"2000":122,"2001":134,"2002":130,"2003":135,"2004":122,"2005":136,"2006":133,"2007":137,"2008":138,"2009":131,"2010":134,"2011":47,"2012":139,"2013":131,"2014":134,"2015":131,"2016":135,"2017":140,"2018":132,"2019":131,"2020":141,"2021":122,"2022":142,"2023":130,"2024":123},12,17,18,19,20,25,28,27,22,21,24,38,35,37,26,39,36,1403,{"1980":40,"1982":40,"1983":40,"1991":132,"1992":45,"1993":48,"1994":49,"1995":145,"1996":146,"1997":134,"1998":140,"1999":47,"2000":136,"2001":127,"2002":128,"2003":147,"2004":148,"2005":131,"2006":149,"2007":150,"2008":151,"2009":152,"2010":153,"2011":154,"2012":155,"2013":156,"2014":152,"2015":157,"2016":158,"2017":138,"2018":159,"2019":160,"2020":159,"2021":161,"2022":162,"2023":45},9,13,31,30,46,40,65,43,119,105,89,72,63,66,70,59,68,58,1.34,{"1980":165,"1982":106,"1983":112,"1991":166,"1992":167,"1993":52,"1994":168,"1995":169,"1996":170,"1997":171,"1998":172,"1999":119,"2000":172,"2001":173,"2002":174,"2003":175,"2004":176,"2005":172,"2006":177,"2007":178,"2008":179,"2009":180,"2010":181,"2011":182,"2012":183,"2013":184,"2014":185,"2015":186,"2016":187,"2017":188,"2018":189,"2019":190,"2020":191,"2021":192,"2022":193,"2023":194},0.06,1.47,0.22,0.25,0.33,0.48,0.79,1.04,0.77,0.9,1.48,1.3,1.7,1.05,1.86,1.72,5.41,9.55,2.41,2.88,1.95,2.52,3.14,1.35,2.5,2.36,1.79,2.96,1.61,0.2,{"impactFactor":28,"impactFactorByYear":28,"i10Index":196,"i10IndexLast5Year":128,"totalPublication":197,"totalPublicationByYear":198,"totalCitation":203,"totalCitationByYear":204,"totalCitationPerPublication":219,"totalCitationPerPublicationByYear":220,"hindexLast5Year":126,"hindex":199},42,1244,{"0":147,"1979":146,"1980":127,"1981":127,"1982":199,"1983":199,"1984":129,"1985":129,"1986":128,"1987":129,"1988":51,"1989":140,"1990":127,"1991":129,"1992":129,"1993":133,"1994":147,"1995":132,"1996":69,"1997":132,"1998":131,"1999":134,"2000":140,"2001":131,"2002":134,"2003":131,"2004":133,"2005":132,"2006":131,"2007":200,"2008":138,"2009":140,"2010":132,"2011":122,"2012":201,"2013":132,"2014":140,"2015":148,"2016":122,"2017":202,"2018":69,"2019":140,"2020":69,"2021":132,"2022":139,"2023":130,"2024":133,"2025":131,"2026":138},16,47,41,32,2194,{"1997":126,"1998":205,"1999":126,"2000":145,"2001":145,"2002":126,"2003":205,"2004":127,"2005":129,"2006":146,"2007":132,"2008":136,"2009":47,"2010":131,"2011":138,"2012":206,"2013":207,"2014":208,"2015":162,"2016":209,"2017":209,"2018":210,"2019":211,"2020":212,"2021":213,"2022":214,"2023":215,"2024":216,"2025":217,"2026":218},10,54,64,62,93,123,118,122,168,159,177,205,255,154,1.76,{"1997":221,"1998":222,"1999":223,"2000":224,"2001":118,"2002":223,"2003":222,"2004":225,"2005":226,"2006":115,"2007":227,"2008":228,"2009":229,"2010":230,"2011":231,"2012":232,"2013":233,"2014":234,"2015":235,"2016":236,"2017":237,"2018":238,"2019":239,"2020":240,"2021":48,"2022":241,"2023":242,"2024":243,"2025":244,"2026":245},0.43,0.4,0.55,0.35,0.63,0.68,0.6,0.69,0.42,0.89,1.52,1.32,2.29,2.38,1.93,4.04,2.91,4.24,4.54,4.21,4.3,8.85,7.59,10.2,4.4,{"id":247,"createTime":248,"updateTime":10,"relativeEntities":249,"slug":250,"properties":251,"entityType":25,"verifyStatus":26,"verifyTime":261,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":147,"subjectFields":262,"manageAffiliations":263,"indexDatabases":264,"url":273,"thumbnailPath":28,"statistic":274,"gsStatistic":290,"type":55,"analyzePriority":28},"b5209d2b-2258-40ef-8732-874e80fe24a5","2023-08-01T04:13:30.887+00:00",[],"VNU-Journal-of-Science-Medical-and-Pharmaceutical-Sciences",{"country":252,"eissn":253,"issn":255,"title":257,"gsId":259},{"VOID":15},{"VOID":254},"25881132",{"VOID":256},"26159309",{"EN":258},"VNU Journal of Science: Medical and Pharmaceutical Sciences",{"VOID":260},"nxupvWQAAAAJ","2023-08-01T04:16:22.633+00:00",[],[],[265],{"id":266,"indexDatabase":267,"url":272,"indexYears":28,"academicFieldIds":28,"indexDatabaseRanking":28},"1c684ac3-c7bf-4466-8841-3c6146083c3c",{"id":88,"createTime":28,"updateTime":28,"relativeEntities":268,"label":269,"description":270,"key":94,"publicationTags":271,"standard":28},[],{"EN":91,"VI":91},{"EN":93,"VI":93},[96],"https:\u002F\u002Fasean-cites.org\u002Fjournal_info?jid=11969","https:\u002F\u002Fjs.vnu.edu.vn\u002FMPS",{"impactFactor":32,"impactFactorByYear":275,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":276,"totalPublicationByYear":277,"totalCitation":282,"totalCitationByYear":283,"totalCitationPerPublication":284,"totalCitationPerPublicationByYear":285,"hindexLast5Year":45,"hindex":45},{"2019":106,"2020":110,"2021":104,"2022":104,"2023":109,"2024":108},360,{"2016":140,"2017":278,"2018":69,"2019":148,"2020":279,"2021":200,"2022":280,"2023":281,"2024":200},34,48,49,50,163,{"2016":145,"2017":145,"2018":135,"2019":140,"2020":50,"2021":135,"2022":128,"2023":48},0.45,{"2016":224,"2017":117,"2018":286,"2019":287,"2020":288,"2021":284,"2022":289,"2023":104},0.72,0.87,1.1,0.37,{"impactFactor":28,"impactFactorByYear":28,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":136,"totalPublicationByYear":291,"totalCitation":127,"totalCitationByYear":292,"totalCitationPerPublication":293,"totalCitationPerPublicationByYear":294,"hindexLast5Year":123,"hindex":42},{"0":123,"2014":40,"2015":40,"2016":130},{"2016":40,"2019":123,"2021":123,"2023":45,"2024":42,"2025":40,"2026":40},0.71,{"2016":106},{"id":296,"createTime":297,"updateTime":10,"relativeEntities":298,"slug":299,"properties":300,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":51,"subjectFields":310,"manageAffiliations":311,"indexDatabases":312,"url":313,"thumbnailPath":28,"statistic":314,"gsStatistic":349,"type":55,"analyzePriority":28},"e7ce3904-ad2d-4341-b39e-98ebe8da5908","2023-06-13T10:30:04.853+00:00",[],"Communications-in-Physics",{"country":301,"eissn":302,"issn":304,"title":306,"gsId":308},{"VOID":15},{"VOID":303},"28155947",{"VOID":305},"08863166",{"EN":307},"Communications in Physics",{"VOID":309},"FStER9AAAAAJ",[],[],[],"https:\u002F\u002Fvjs.ac.vn\u002Findex.php\u002Fcip",{"impactFactor":32,"impactFactorByYear":315,"i10Index":199,"i10IndexLast5Year":45,"totalPublication":321,"totalPublicationByYear":322,"totalCitation":326,"totalCitationByYear":327,"totalCitationPerPublication":335,"totalCitationPerPublicationByYear":336,"hindexLast5Year":126,"hindex":126},{"2008":110,"2009":316,"2010":165,"2011":317,"2012":317,"2013":112,"2014":318,"2015":105,"2016":108,"2017":116,"2018":318,"2019":52,"2020":319,"2021":284,"2022":320,"2023":116,"2024":222},0.3,0.03,0.16,0.34,0.28,738,{"2007":323,"2008":145,"2009":145,"2010":136,"2011":139,"2012":324,"2013":138,"2014":151,"2015":69,"2016":151,"2017":325,"2018":142,"2019":50,"2020":201,"2021":141,"2022":152,"2023":150,"2024":278,"2025":123},14,107,56,947,{"2007":148,"2008":49,"2009":49,"2010":127,"2011":328,"2012":155,"2013":278,"2014":329,"2015":206,"2016":330,"2017":331,"2018":332,"2019":333,"2020":334,"2021":127,"2022":132,"2023":148},52,94,86,129,76,91,106,1.28,{"2007":337,"2008":338,"2009":338,"2010":293,"2011":339,"2012":340,"2013":341,"2014":342,"2015":179,"2016":232,"2017":343,"2018":344,"2019":180,"2020":345,"2021":346,"2022":347,"2023":348},2.14,0.78,1.41,0.83,0.97,1.45,2.3,2.11,2.59,0.44,0.65,0.75,{"impactFactor":28,"impactFactorByYear":28,"i10Index":133,"i10IndexLast5Year":145,"totalPublication":350,"totalPublicationByYear":351,"totalCitation":355,"totalCitationByYear":356,"totalCitationPerPublication":363,"totalCitationPerPublicationByYear":364,"hindexLast5Year":145,"hindex":323},1117,{"0":48,"1972":40,"1991":127,"1992":51,"1993":49,"1994":47,"1995":323,"1996":42,"1997":40,"1998":146,"1999":146,"2000":205,"2001":47,"2002":128,"2003":136,"2004":132,"2005":136,"2006":148,"2007":141,"2008":149,"2009":352,"2010":353,"2011":196,"2012":208,"2013":280,"2014":354,"2015":150,"2016":328,"2017":137,"2018":142,"2019":325,"2020":152,"2021":139,"2022":139,"2023":142,"2024":148,"2025":147,"2026":132},33,44,92,1611,{"2004":46,"2005":357,"2006":47,"2007":47,"2008":126,"2009":140,"2010":69,"2011":147,"2012":147,"2013":147,"2014":208,"2015":353,"2016":201,"2017":280,"2018":161,"2019":358,"2020":212,"2021":331,"2022":212,"2023":359,"2024":360,"2025":361,"2026":362},8,85,153,178,188,132,1.44,{"2004":365,"2005":169,"2006":289,"2007":320,"2008":117,"2009":171,"2010":366,"2011":367,"2012":368,"2013":225,"2014":369,"2015":288,"2016":171,"2017":370,"2018":371,"2019":231,"2020":372,"2021":373,"2022":374,"2023":375,"2024":376,"2025":377,"2026":378},0.18,0.66,0.74,0.5,0.67,1.29,1.89,2.84,3.49,3.3,4.25,5.93,6.06,4.71,{"id":380,"createTime":381,"updateTime":382,"relativeEntities":383,"slug":384,"properties":385,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":394,"translateLanguages":28,"viewCount":127,"subjectFields":395,"manageAffiliations":396,"indexDatabases":404,"url":418,"thumbnailPath":28,"statistic":419,"gsStatistic":446,"type":55,"analyzePriority":28},"2300fd63-13a8-4ee9-92b0-d24d9e616c6b","2023-05-29T12:05:31.684+00:00","2026-08-27T01:57:29.561+00:00",[],"Journal-of-Computer-Science-and-Cybernetics",{"country":386,"issn":387,"title":389,"gsId":392},{"VOID":15},{"VOID":388},"18139663",{"EN":390,"VI":391},"Journal of Computer Science and Cybernetics","Tạp chí tin học và điều khiển học",{"VOID":393},"hVh9fuMAAAAJ",[30,31],[],[397],{"id":73,"createTime":28,"updateTime":28,"relativeEntities":398,"slug":28,"properties":399,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":82,"parentIds":403,"statistic":28},[],{"title":400,"country":401,"abbreviation":402},{"EN":77,"VI":78},{"VOID":15},{"VOID":81},[],[405],{"id":406,"indexDatabase":407,"url":412,"indexYears":413,"academicFieldIds":414,"indexDatabaseRanking":28},"0c897c2c-8ca4-4a7a-91b9-14955abc3043",{"id":88,"createTime":28,"updateTime":28,"relativeEntities":408,"label":409,"description":410,"key":94,"publicationTags":411,"standard":28},[],{"EN":91,"VI":91},{"EN":93,"VI":93},[96],"https:\u002F\u002Fasean-cites.org\u002Fjournal_info?jid=11305","2019-2021",[100,415,416,417],"a24a4497-b6ac-43f3-ae94-c044be819e49","b2d37900-0c9f-4074-a519-9ee0b570caa7","37da756c-1c5e-4925-87f2-a9bd3ce5859c","http:\u002F\u002Fvjs.ac.vn\u002Findex.php\u002Fjcc",{"impactFactor":32,"impactFactorByYear":420,"i10Index":129,"i10IndexLast5Year":42,"totalPublication":425,"totalPublicationByYear":426,"totalCitation":431,"totalCitationByYear":432,"totalCitationPerPublication":438,"totalCitationPerPublicationByYear":439,"hindexLast5Year":323,"hindex":323},{"2013":107,"2014":107,"2015":111,"2016":365,"2017":107,"2018":421,"2019":117,"2020":422,"2021":227,"2022":423,"2023":368,"2024":424},0.04,0.32,0.39,0.57,1184,{"2012":427,"2013":358,"2014":278,"2015":428,"2016":429,"2017":51,"2018":430,"2019":148,"2020":130,"2021":136,"2022":199,"2023":132,"2024":42},473,71,251,134,995,{"2012":433,"2013":434,"2014":434,"2015":333,"2016":435,"2017":436,"2018":437,"2019":211,"2020":281,"2021":434,"2022":126,"2023":152},149,45,114,51,232,0.84,{"2012":422,"2013":440,"2014":232,"2015":335,"2016":284,"2017":441,"2018":442,"2019":443,"2020":189,"2021":444,"2022":348,"2023":445},0.53,3.4,1.73,3.93,1.88,1.54,{"impactFactor":28,"impactFactorByYear":28,"i10Index":150,"i10IndexLast5Year":132,"totalPublication":447,"totalPublicationByYear":448,"totalCitation":449,"totalCitationByYear":450,"totalCitationPerPublication":192,"totalCitationPerPublicationByYear":460,"hindexLast5Year":51,"hindex":199},1105,{"0":47,"1981":40,"1985":199,"1986":135,"1987":136,"1988":323,"1989":126,"1990":199,"1991":127,"1992":126,"1993":47,"1994":129,"1995":130,"1996":132,"1997":142,"1998":148,"1999":201,"2000":196,"2001":353,"2002":353,"2003":352,"2004":132,"2005":131,"2006":148,"2007":147,"2008":133,"2009":131,"2010":139,"2011":201,"2012":281,"2013":142,"2014":202,"2015":69,"2016":140,"2017":136,"2018":140,"2019":134,"2020":134,"2021":133,"2022":134,"2023":134,"2024":136,"2025":49},3272,{"2007":145,"2008":323,"2009":46,"2010":48,"2011":129,"2012":148,"2013":140,"2014":69,"2015":152,"2016":160,"2017":162,"2018":451,"2019":452,"2020":453,"2021":454,"2022":455,"2023":456,"2024":457,"2025":458,"2026":459},109,173,236,318,398,469,442,440,297,{"2007":461,"2008":115,"2009":194,"2010":318,"2011":462,"2012":227,"2013":286,"2014":463,"2015":175,"2016":464,"2017":465,"2018":466,"2019":467,"2020":468,"2021":469,"2022":470,"2023":471,"2024":472,"2025":473},0.29,0.46,0.91,2.27,2.42,4.19,7.86,10.73,11.78,18.09,21.32,18.42,62.86,{"id":475,"createTime":476,"updateTime":382,"relativeEntities":477,"slug":478,"properties":479,"entityType":25,"verifyStatus":26,"verifyTime":491,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":202,"subjectFields":492,"manageAffiliations":493,"indexDatabases":509,"url":510,"thumbnailPath":28,"statistic":511,"gsStatistic":525,"type":55,"analyzePriority":28},"25b6bd10-676c-40c0-8dc3-356d1679a284","2023-05-19T02:22:33.430+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Y-D%C6%B0%E1%BB%A3c-h%E1%BB%8Dc-C%E1%BA%A7n-Th%C6%A1",{"country":480,"issn":481,"title":483,"introduce":486,"gsId":489},{"VOID":15},{"VOID":482},"23541210",{"EN":484,"VI":485},"Cantho Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. Since then, the journal has grown in quality, size and scope and now comprises a dozen of serials spanning academic research. In 2002, with the rapid expansion of the field of Foreign Languages and International Studies, the \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was delighted to announce the launch of the \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science: Foreign Studies\"},{\"insert\":\"\\n.\\n\\n\\nSince 2017, as a natural development from its predecessor \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science: Foreign Studies\"},{\"insert\":\"\\n, the\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\" \"},{\"attributes\":{\"italic\":true,\"bold\":true},\"insert\":\"VNU Journal of Foreign Studies \"},{\"insert\":\"\\ncontinues to be an official, independent publication of the University of Languages and International Studies (ULIS) under Vietnam National University (VNU).\\nThe\\n\"},{\"attributes\":{\"italic\":true,\"bold\":true},\"insert\":\" VNU Journal of Foreign Studies\"},{\"attributes\":{\"italic\":true},\"insert\":\" \"},{\"insert\":\"\\npublishes \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"blind\"},{\"insert\":\"\\n \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"peer-reviewed\"},{\"insert\":\"\\n research papers, discussions and reviews concerning:\\nLinguisticsForeign language educationInternational studiesRelated social sciences and humanities\\nBimonthly in 4 English editions and 2 Vietnamese editions in the current year in both print and electronic forms, the journal provides maximum exposure for published articles, making research available to all to read and share.\\n\\n\\n\"}]}","{\"ops\":[{\"attributes\":{\"italic\":true},\"insert\":\"Tạp chí Khoa học, Đại học Quốc gia Hà Nội\"},{\"insert\":\"\\n được thành lập năm 1985 với mục đích xuất bản các bài báo nghiên cứu trong nước và quốc tế về tất cả các lĩnh vực khoa học tự nhiên và công nghệ, khoa học xã hội và nhân văn. Kể từ đó, tạp chí đã phát triển về chất lượng, quy mô và phạm vi với hàng chục số báo liên quan đến nghiên cứu học thuật. Năm 2002, với sự phát triển nhanh chóng của lĩnh vực Ngoại ngữ và Quốc tế học, \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"Tạp chí Khoa học Đại học Quốc gia Hà Nội\"},{\"insert\":\"\\n đã vui mừng thông báo ra mắt Chuyên san \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"Nghiên cứu Nước ngoài.\"},{\"insert\":\"\\n\\n\\nKể từ năm 2017, như một sự kế thừa và phát triển từ tiền thân Chuyên san \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"Nghiên cứu Nước ngoài\"},{\"insert\":\"\\n của Tạp chí Khoa học, Đại học Quốc gia Hà Nội, \\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Tạp chí\"},{\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\" \"},{\"insert\":\"\\n\"},{\"attributes\":{\"italic\":true,\"bold\":true},\"insert\":\"Nghiên cứu nước ngoài \"},{\"insert\":\"\\ntiếp tục là ấn phẩm khoa học chính thức và độc lập của Trường Đại học Ngoại ngữ, Đại học Quốc gia Hà Nội.\\nTạp chí \\n\"},{\"attributes\":{\"italic\":true,\"bold\":true},\"insert\":\"Nghiên cứu nước ngoài\"},{\"insert\":\"\\n xuất bản các bài báo nghiên cứu, trao đổi và đánh giá đã được phản biện kín về:\\nNgôn ngữ họcGiảng dạy ngoại ngữ\u002Fngôn ngữQuốc tế họcCác ngành khoa học xã hội và nhân văn có liên quan\\nTạp chí xuất bản định kì 06 số\u002Fnăm (gồm 04 số tiếng Anh\u002Fnăm và 2 số tiếng Việt\u002Fnăm) dưới dạng bản in và bản điện tử. Tạp chí cung cấp khả năng tiếp cận tối đa tới các bài báo đã xuất bản nhằm giúp độc giả dễ dàng đọc và chia sẻ.\\n\"}]}",{"VOID":551},"jyihv3YAAAAJ",[30,31],[],[],[],"https:\u002F\u002Fjfs.ulis.vnu.edu.vn\u002Findex.php\u002Ffs","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F6984a56a-db70-403b-9cc4-4013e1ceaffa\u002F92693604f5caf63c64520c5c2cd756b5.jpg",{"impactFactor":32,"impactFactorByYear":559,"i10Index":560,"i10IndexLast5Year":205,"totalPublication":561,"totalPublicationByYear":562,"totalCitation":568,"totalCitationByYear":569,"totalCitationPerPublication":579,"totalCitationPerPublicationByYear":580,"hindexLast5Year":140,"hindex":140},{"2007":317,"2010":112,"2011":109,"2012":421,"2013":165,"2014":421,"2015":421,"2016":111,"2017":116,"2018":104,"2019":109,"2020":320,"2021":284,"2022":168,"2023":116,"2024":108},67,1200,{"2002":51,"2003":51,"2004":47,"2005":352,"2006":142,"2007":131,"2008":147,"2009":139,"2010":278,"2011":138,"2012":69,"2013":206,"2014":137,"2015":69,"2016":196,"2017":563,"2018":209,"2019":564,"2020":565,"2021":566,"2022":530,"2023":567,"2024":428,"2025":281},130,78,90,80,61,3204,{"2002":42,"2003":123,"2004":123,"2005":570,"2006":47,"2007":127,"2008":571,"2009":572,"2010":196,"2011":573,"2012":130,"2013":560,"2014":574,"2015":149,"2016":325,"2017":575,"2018":576,"2019":577,"2020":578,"2021":453,"2022":206,"2023":205,"2025":51},189,223,765,246,98,171,377,355,199,2.67,{"2002":194,"2003":116,"2004":365,"2005":581,"2006":582,"2007":226,"2008":583,"2009":584,"2010":585,"2011":586,"2012":228,"2013":585,"2014":587,"2015":588,"2016":589,"2017":232,"2018":590,"2019":591,"2020":592,"2021":593,"2022":347,"2023":318,"2025":316},5.73,0.31,7.19,20.68,1.24,7.03,2.58,1.59,1.33,4.05,4.55,2.21,2.95,{"impactFactor":28,"impactFactorByYear":28,"i10Index":595,"i10IndexLast5Year":596,"totalPublication":597,"totalPublicationByYear":598,"totalCitation":609,"totalCitationByYear":610,"totalCitationPerPublication":625,"totalCitationPerPublicationByYear":626,"hindexLast5Year":142,"hindex":152},379,311,2120,{"0":361,"1960":40,"1971":40,"1975":40,"1987":40,"1988":40,"1989":40,"1990":45,"1992":40,"1993":40,"1994":46,"1995":46,"1996":45,"1997":42,"1998":49,"1999":42,"2000":123,"2001":42,"2002":48,"2003":46,"2004":145,"2005":131,"2006":51,"2007":131,"2008":135,"2009":146,"2010":127,"2011":122,"2012":148,"2013":352,"2014":201,"2015":149,"2016":599,"2017":600,"2018":601,"2019":209,"2020":602,"2021":603,"2022":604,"2023":605,"2024":606,"2025":607,"2026":608},77,75,97,143,167,156,182,231,230,128,13225,{"2003":149,"2004":150,"2005":201,"2006":196,"2007":157,"2008":436,"2009":328,"2010":611,"2011":612,"2012":333,"2013":522,"2014":613,"2015":520,"2016":614,"2017":615,"2018":616,"2019":617,"2020":618,"2021":619,"2022":620,"2023":621,"2024":622,"2025":623,"2026":624},74,88,146,228,310,347,413,636,944,1261,1400,1846,2511,1882,6.24,{"2003":627,"2004":628,"2005":629,"2006":630,"2007":186,"2008":631,"2009":45,"2010":632,"2011":633,"2012":634,"2013":42,"2014":635,"2015":636,"2016":192,"2017":637,"2018":638,"2019":628,"2020":639,"2021":640,"2022":641,"2023":642,"2024":643,"2025":644,"2026":645},9.2,4.44,1.64,2.8,2.43,4.35,3.83,3.03,3.56,3.5,4.13,3.58,4.45,5.65,8.08,7.69,7.99,10.92,14.7,{"id":647,"createTime":648,"updateTime":382,"relativeEntities":649,"slug":650,"properties":651,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":664,"languages":665,"translateLanguages":28,"viewCount":142,"subjectFields":666,"manageAffiliations":667,"indexDatabases":668,"url":677,"thumbnailPath":678,"statistic":679,"gsStatistic":699,"type":55,"analyzePriority":28},"21d239d8-ac9d-48c7-a176-9d8aadc5eba5","2023-08-21T02:43:48.721+00:00",[],"Khoa-h%E1%BB%8Dc-%C4%90HQGHN-Khoa-h%E1%BB%8Dc-T%E1%BB%B1-nhi%C3%AAn-v%C3%A0-C%C3%B4ng-ngh%E1%BB%87",{"country":652,"eissn":653,"issn":655,"title":657,"introduce":660,"gsId":662},{"VOID":15},{"VOID":654},"25881140",{"VOID":656},"26159317",{"EN":658,"VI":659},"VNU Journal of Science: Natural Science and Technology","Khoa học ĐHQGHN: Khoa học Tự nhiên và Công nghệ",{"EN":661},"{\"ops\":[{\"insert\":\"The \"},{\"attributes\":{\"italic\":true},\"insert\":\"Journal\"},{\"insert\":\" \"},{\"attributes\":{\"italic\":true},\"insert\":\"of\"},{\"insert\":\" \"},{\"attributes\":{\"italic\":true},\"insert\":\"Science\"},{\"insert\":\" was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. Since then, the journal has grown in quality, size and scope and now comprises a dozen of serials spanning academic research.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"With the rapid expansion of the field of Economics, the VNU \"},{\"attributes\":{\"italic\":true},\"insert\":\"Journal\"},{\"insert\":\" \"},{\"attributes\":{\"italic\":true},\"insert\":\"of\"},{\"insert\":\" \"},{\"attributes\":{\"italic\":true},\"insert\":\"Science\"},{\"insert\":\" is delighted to announce the launch of the \"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science: Natural Sciences and Technology (JS: NST) \"},{\"insert\":\"since 1985. This serial publication provides researchers with the opportunity to publish research covering aspects in these areas in the popular \"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\" series.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"As a fully open access publication, the journal will provide maximum exposure for published articles, making the research available to all to read and share. The journal will be published quarterly in March, June, September and December.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Scope\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"JS: NST is an open access journal publishing double-blinded peer-reviewed research papers, communications and reviews dealing with Biology, Bio-technology, Chemistry, Chemical engineering, Energy, Environmental technology and Materials engineering.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Publication Ethics\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"VNUJS is committed to maintaining the highest standards of publication ethics and takes all possible measures against any publication malpractices. The journal follows the guidelines and recommendations of the Committee on Publication Ethics (C.O.P.E) to ensure ethical publishing practices.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Plagiarism is strictly prohibited and will not be tolerated. Any form of plagiarism, including but not limited to copying, paraphrasing, or reusing previously published work without proper attribution, will result in rejection of the manuscript and potential sanctions against the author. VNUJS utilizes DoIt as plagiarism detection software to verify the originality of submitted manuscripts.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"The publication ethics statement with full detail of the responsibilities of authors, reviewers and editors can be found \"},{\"attributes\":{\"bold\":true,\"color\":\"#464d50\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fjs.vnu.edu.vn\u002FNST\u002Fethics\"},\"insert\":\"here\"},{\"attributes\":{\"bold\":true},\"insert\":\".\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Peer Review Process\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Any manuscript followed the journal’s scope and author guideline will be assigned to the managing editors. All manuscripts have undergone editorial screening and anonymous double-blind peer-review by the at least one independent expert in the field. The managing editor makes an editorial decision, which is subject to endorsement by the Editor – in - Chief.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"The journal publishing process can be found in detail \"},{\"attributes\":{\"bold\":true,\"color\":\"#464d50\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fdrive.google.com\u002Ffile\u002Fd\u002F136BOGahfq9_5BB3TzSBsLBkQKfCUe5yN\u002Fview?usp=share_link\"},\"insert\":\"here\"},{\"insert\":\".\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"\\n\"}]}",{"VOID":663},"ZfBridMAAAAJ","Admin update database",[30,31],[],[],[669],{"id":670,"indexDatabase":671,"url":676,"indexYears":28,"academicFieldIds":28,"indexDatabaseRanking":28},"6684da33-2cb9-49f9-8332-28f0bcd72e39",{"id":88,"createTime":28,"updateTime":28,"relativeEntities":672,"label":673,"description":674,"key":94,"publicationTags":675,"standard":28},[],{"EN":91,"VI":91},{"EN":93,"VI":93},[96],"https:\u002F\u002Fasean-cites.org\u002Fjournal_info?jid=11968","https:\u002F\u002Fjs.vnu.edu.vn\u002FNST","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F21d239d8-ac9d-48c7-a176-9d8aadc5eba5\u002Fb081d4211e382646c2cdc054ead551b3.jpg",{"impactFactor":32,"impactFactorByYear":680,"i10Index":130,"i10IndexLast5Year":40,"totalPublication":682,"totalPublicationByYear":683,"totalCitation":685,"totalCitationByYear":686,"totalCitationPerPublication":691,"totalCitationPerPublicationByYear":692,"hindexLast5Year":47,"hindex":47},{"2000":317,"2005":513,"2007":107,"2010":513,"2011":317,"2012":106,"2013":107,"2014":317,"2015":107,"2016":107,"2017":421,"2018":317,"2019":421,"2020":113,"2021":582,"2022":681,"2023":194,"2024":104},0.19,1700,{"1985":131,"1986":353,"1987":130,"1988":69,"1989":69,"1990":200,"1991":196,"1992":146,"1993":279,"1994":148,"1995":200,"1996":201,"1999":278,"2000":140,"2001":128,"2002":202,"2003":353,"2004":138,"2005":202,"2006":136,"2007":278,"2008":139,"2009":137,"2010":141,"2011":278,"2012":132,"2013":202,"2014":202,"2015":278,"2016":684,"2017":359,"2018":160,"2019":162,"2020":281,"2021":157,"2022":436,"2023":358,"2024":136,"2025":135},165,870,{"1995":123,"1999":123,"2001":45,"2002":130,"2003":40,"2004":123,"2005":42,"2007":69,"2008":687,"2009":352,"2010":688,"2011":137,"2012":127,"2013":47,"2014":46,"2015":146,"2016":331,"2017":689,"2018":331,"2019":690,"2020":353,"2021":567,"2022":130,"2023":357},82,60,55,102,0.51,{"1995":421,"1999":165,"2001":167,"2002":532,"2003":107,"2004":165,"2005":111,"2007":693,"2008":694,"2009":287,"2010":445,"2011":695,"2012":119,"2013":319,"2014":318,"2015":696,"2016":338,"2017":118,"2018":697,"2019":219,"2020":698,"2021":341,"2022":423,"2023":111},0.85,2.22,1.12,0.38,2.19,0.88,{"impactFactor":28,"impactFactorByYear":28,"i10Index":126,"i10IndexLast5Year":123,"totalPublication":570,"totalPublicationByYear":700,"totalCitation":701,"totalCitationByYear":702,"totalCitationPerPublication":703,"totalCitationPerPublicationByYear":704,"hindexLast5Year":46,"hindex":205},{"0":48,"1999":146,"2000":47,"2001":45,"2002":40,"2003":199,"2004":123,"2005":42,"2006":123,"2007":145,"2008":145,"2009":46,"2010":49,"2011":47,"2012":47,"2013":49,"2014":45,"2015":45,"2016":157,"2017":40},425,{"2008":42,"2009":357,"2010":47,"2011":51,"2012":199,"2013":135,"2014":323,"2015":51,"2016":278,"2017":69,"2018":69,"2019":137,"2020":142,"2021":140,"2022":148,"2023":122,"2024":202,"2025":135,"2026":126},2.25,{"2008":169,"2009":705,"2010":706,"2011":707,"2012":342,"2013":42,"2014":636,"2015":708,"2016":709,"2017":69},1.6,1.57,1.36,3.75,0.54,{"id":711,"createTime":712,"updateTime":382,"relativeEntities":713,"slug":714,"properties":715,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":664,"languages":28,"translateLanguages":28,"viewCount":150,"subjectFields":727,"manageAffiliations":728,"indexDatabases":729,"url":730,"thumbnailPath":731,"statistic":732,"gsStatistic":738,"type":55,"analyzePriority":28},"954132b5-ca74-461c-b819-45ad6e49a404","2023-08-17T03:30:52.301+00:00",[],"HPU2-Journal-of-Science-Natural-Sciences-and-Technology",{"country":716,"issn":717,"title":719,"introduce":722,"gsId":725},{"VOID":15},{"VOID":718},"28155637",{"EN":720,"VI":721},"HPU2 Journal of Science: Natural Sciences and Technology","TẠP CHÍ KHOA HỌC TRƯỜNG ĐHSP HÀ NỘI 2: CHUYÊN SAN KHOA HỌC TỰ NHIÊN VÀ CÔNG NGHỆ",{"EN":723,"VI":724},"{\"ops\":[{\"insert\":\"HPU2 journal of Science aims to provide an interdisciplinary platform for the dissemination of advances in sciences and technology. The journal publishes original papers of scientific or technological value in all areas of natural, social or educational sciences.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"The main interest of HPU2 Journal of Science: Natural sciences and technology is in papers that describe valuable findings in physics, mathematics, chemistry, biology; solving engineering or technological problems.\"},{\"attributes\":{\"align\":\"justify\",\"list\":\"bullet\"},\"insert\":\"\\n\"},{\"insert\":\"The main interest of HPU2 Journal of Science: Social Sciences and Humanity is to facilitate the publication of high-quality papers in various areas of social sciences and studies for human development.\"},{\"attributes\":{\"align\":\"justify\",\"list\":\"bullet\"},\"insert\":\"\\n\"},{\"insert\":\"The main interest of HPU2 Journal of Science: Educational Sciences is to publish papers in the field of educational sciences and applications of advances to education for improving and enhancing science education at all levels.\"},{\"attributes\":{\"align\":\"justify\",\"list\":\"bullet\"},\"insert\":\"\\n\"},{\"insert\":\"Papers that are published by HPU2 Journal of Science are doubled-blind, peer-reviewed by at least two experts, are evaluated by the section editor and editor in chief.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Types of Articles\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Research articles\"},{\"attributes\":{\"align\":\"justify\",\"list\":\"bullet\"},\"insert\":\"\\n\"},{\"insert\":\"Academic reports of original research that have never been published elsewhere in any languages. Manuscripts, where appropriate, should contain the following sections in the order: Title, Authors, Author affiliations, Email address of corresponding authors, Abstract, Keywords, Nomenclature (if any), Introduction, Experiment, Theory, Results and Discussion, Conclusions, Conflict of Interest, Acknowledgments (if any), References, Appendix (if any). Pre-published are to be formatted according to Templates (MS-Word version). \"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Review articles\"},{\"attributes\":{\"align\":\"justify\",\"list\":\"bullet\"},\"insert\":\"\\n\"},{\"insert\":\"In addition to invited reviews, literature reviews, systematic reviews, and critical reviews will be accepted for consideration. The manuscript should be composed and organized according to the required sequence: Titles, Author names, Affiliations, Email addresses, Abstract, Keywords, Main text, Conclusion, Conflict of Interest, Acknowledgments (if any), References. Although, the main text structure may vary based on the review subtopics, the articles should be formatted according to suitable Templates as research articles.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"\\n\"}]}","{\"ops\":[{\"insert\":\"Tạp chí Khoa học Trường ĐHSP Hà Nội 2 nhằm mục đích cung cấp một nền tảng liên ngành của sự phổ biến những tiến bộ của khoa học và công nghệ. Tạp chí xuất bản các bài báo gốc có giá trị khoa học hoặc công nghệ trong tất cả các lĩnh vực khoa học tự nhiên, xã hội hoặc giáo dục.\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Chuyên san Khoa học tự nhiên và công nghệ:\"},{\"insert\":\" Là các bài báo mô tả những phát hiện có giá trị trong vật lý, toán học, hóa học, sinh học; giải quyết các vấn đề kỹ thuật hoặc công nghệ.\"},{\"attributes\":{\"list\":\"bullet\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Chuyên san Khoa học Xã hội và Nhân văn:\"},{\"insert\":\" là các bài báo xuất bản chất lượng cao trong các lĩnh vực khác nhau của khoa học xã hội và nghiên cứu phát triển con người.\"},{\"attributes\":{\"list\":\"bullet\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Chuyên san Khoa học giáo dục:\"},{\"insert\":\" là các bài báo xuất bản trong lĩnh vực khoa học giáo dục và các ứng dụng của tiến bộ vào giáo dục để cải thiện và nâng cao giáo dục khoa học ở tất cả các cấp.\"},{\"attributes\":{\"list\":\"bullet\"},\"insert\":\"\\n\"},{\"insert\":\"Tạp chí trường ĐHSP Hà Nội 2 xuất bản được phản biện kín, xét duyệt bởi ít nhất 02 chuyên gia, và được đánh giá, chọn lựa từ ban biên tập và Tổng biên tập.\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Các loại bài báo\"},{\"insert\":\":\\nBài báo nghiên cứu:\"},{\"attributes\":{\"list\":\"ordered\"},\"insert\":\"\\n\"},{\"insert\":\"Báo cáo học thuật về nghiên cứu ban đầu chưa từng được xuất bản ở bất kỳ nơi nào, hay bằng bất kỳ ngôn ngữ nào khác. Bản thảo thích hợp, nên chứa các phần sau theo thứ tự: Tiêu đề, Tác giả, Liên kết tác giả, Địa chỉ email của tác giả tương ứng, Tóm tắt, Từ khóa, Danh pháp (nếu có), Giới thiệu, Thử nghiệm, Lý thuyết, Kết quả và thảo luận, Kết luận, Xung đột quan tâm, Lời cảm ơn (nếu có), Tài liệu tham khảo, Phụ lục (nếu có). Bản xuất bản trước phải được định dạng theo Mẫu (phiên bản MS-Word).\\n2. Bài báo tổng quan:\\nNgoài các bài phê bình được mời, các bài phê bình tài liệu, bài phê bình có hệ thống và bài phê bình sẽ được chấp nhận để xem xét. Bản thảo cần được soạn thảo và sắp xếp theo trình tự yêu cầu: Tên sách, Tên tác giả, Liên kết, Địa chỉ email, Tóm tắt, Từ khóa, Nội dung chính, Kết luận, Xung đột lợi ích, Lời cảm ơn (nếu có), Tài liệu tham khảo. Mặc dù, cấu trúc văn bản chính có thể thay đổi dựa trên các chủ đề phụ của bài đánh giá, các bài báo nên được định dạng theo các Mẫu phù hợp như các bài báo nghiên cứu.\\n\"}]}",{"VOID":726},"YPoBvsIAAAAJ",[],[],[],"https:\u002F\u002Fsj.hpu2.edu.vn\u002Findex.php\u002Fjournal","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F954132b5-ca74-461c-b819-45ad6e49a404\u002F2790ef1d0a7d7a40a504c2fc1647f670.jpg",{"impactFactor":32,"impactFactorByYear":733,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":329,"totalPublicationByYear":735,"totalCitation":134,"totalCitationByYear":736,"totalCitationPerPublication":524,"totalCitationPerPublicationByYear":737,"hindexLast5Year":123,"hindex":123},{"2024":734},0.17,{"2022":136,"2023":278,"2024":142},{"2022":357,"2023":126,"2024":123},{"2022":169,"2023":224,"2024":165},{"impactFactor":28,"impactFactorByYear":28,"i10Index":45,"i10IndexLast5Year":45,"totalPublication":330,"totalPublicationByYear":739,"totalCitation":154,"totalCitationByYear":740,"totalCitationPerPublication":741,"totalCitationPerPublicationByYear":742,"hindexLast5Year":46,"hindex":46},{"0":123,"2022":134,"2023":136,"2024":69,"2025":145},{"2023":46,"2024":136,"2025":201,"2026":278},1.22,{"2023":113,"2024":340,"2025":743},4.56,{"id":745,"createTime":746,"updateTime":747,"relativeEntities":748,"slug":749,"properties":750,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":69,"subjectFields":762,"manageAffiliations":763,"indexDatabases":771,"url":817,"thumbnailPath":28,"statistic":818,"gsStatistic":850,"type":55,"analyzePriority":28},"21ccdb34-414d-420f-8a60-a592a2fa848e","2023-05-29T10:42:53.358+00:00","2026-08-27T01:57:29.560+00:00",[],"Vietnam-Journal-of-Earth-Sciences",{"country":751,"eissn":752,"issn":754,"title":756,"introduce":758,"gsId":760},{"VOID":15},{"VOID":753},"26159783",{"VOID":755},"08667187",{"EN":757},"Vietnam Journal of Earth Sciences",{"EN":759},"Science of the Earth, formerly Vietnam Journal of Earth Sciences, is a peer-reviewed journal to publish high-quality articles on the entire range of earth sciences and the environment, focused on the Asia Pacific region and their correlations and connections to the globe. The journal publishes fundamental and applied research in earth sciences and the environment, including geology, geophysics, geography, soil science, hydrology, meteorology, oceanography, petroleum, geohazards, environmental sciences, environmental engineering, sustainable development, geoinformatics, geodesy, GIS, and remote sensing.",{"VOID":761},"5htfr3YAAAAJ",[],[764],{"id":73,"createTime":28,"updateTime":28,"relativeEntities":765,"slug":28,"properties":766,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":82,"parentIds":770,"statistic":28},[],{"title":767,"country":768,"abbreviation":769},{"EN":77,"VI":78},{"VOID":15},{"VOID":81},[],[772,783,800],{"id":773,"indexDatabase":774,"url":779,"indexYears":780,"academicFieldIds":781,"indexDatabaseRanking":28},"dadb15a8-ee22-41c2-a287-49e969d9a998",{"id":88,"createTime":28,"updateTime":28,"relativeEntities":775,"label":776,"description":777,"key":94,"publicationTags":778,"standard":28},[],{"EN":91,"VI":91},{"EN":93,"VI":93},[96],"https:\u002F\u002Fasean-cites.org\u002Fjournal_info?jid=10629","2016-2022",[782],"e04f14cf-280b-4aa8-b711-b77ddd79cbaf",{"id":784,"indexDatabase":785,"url":795,"indexYears":796,"academicFieldIds":797,"indexDatabaseRanking":799},"6ace2085-a177-4a27-b309-8813b832111e",{"id":786,"createTime":28,"updateTime":28,"relativeEntities":787,"label":788,"description":790,"key":792,"publicationTags":793,"standard":28},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9",[],{"EN":789,"VI":789},"Scopus - Elsevier",{"EN":789,"VI":791},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[794],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F21101039869","2018-2024",[798],"1689391c-5702-4349-aaa7-d720ee4321fc","NONE",{"id":801,"indexDatabase":802,"url":814,"indexYears":28,"academicFieldIds":815,"indexDatabaseRanking":28},"06f278ee-37b9-41eb-a9b0-3d2d77fa502b",{"id":803,"createTime":28,"updateTime":28,"relativeEntities":804,"label":805,"description":807,"key":810,"publicationTags":811,"standard":28},"88bab0f7-443b-476c-a72a-7fa5222da393",[],{"EN":806,"VI":806},"ISI\u002FESCI  - Emerging Sources Citation Index",{"EN":808,"VI":809},"ESCI database","Cơ sở dữ liệu ESCI","esci",[812,813],"ESCI","ISI","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=0866-7187",[816],"0db73426-2364-455f-81a4-efe0f91d712e","https:\u002F\u002Fvjs.ac.vn\u002Findex.php\u002Fjse\u002F",{"impactFactor":32,"impactFactorByYear":819,"i10Index":151,"i10IndexLast5Year":132,"totalPublication":824,"totalPublicationByYear":825,"totalCitation":827,"totalCitationByYear":828,"totalCitationPerPublication":838,"totalCitationPerPublicationByYear":839,"hindexLast5Year":129,"hindex":129},{"2007":513,"2008":513,"2010":513,"2011":107,"2012":513,"2013":513,"2014":317,"2015":107,"2016":54,"2017":168,"2018":222,"2019":820,"2020":821,"2021":371,"2022":445,"2023":822,"2024":823},1.03,1.08,1.49,1.43,1180,{"2000":689,"2001":688,"2002":281,"2003":160,"2004":279,"2005":325,"2006":516,"2007":137,"2008":200,"2009":162,"2010":436,"2011":826,"2012":434,"2013":689,"2014":280,"2015":152,"2016":150,"2017":148,"2018":352,"2019":147,"2020":152,"2021":69,"2022":148,"2023":280,"2024":139,"2025":45},79,2421,{"2000":205,"2001":51,"2002":145,"2003":146,"2004":126,"2005":51,"2006":130,"2007":128,"2008":127,"2009":152,"2010":122,"2011":137,"2012":567,"2013":200,"2014":829,"2015":687,"2016":830,"2017":831,"2018":832,"2019":833,"2020":834,"2021":835,"2022":836,"2023":837,"2024":145,"2025":40},73,197,219,380,281,328,148,183,160,2.05,{"2000":365,"2001":168,"2002":365,"2003":167,"2004":168,"2005":121,"2006":224,"2007":840,"2008":118,"2009":367,"2010":284,"2011":170,"2012":707,"2013":693,"2014":822,"2015":841,"2016":842,"2017":843,"2018":844,"2019":845,"2020":846,"2021":847,"2022":848,"2023":849,"2024":52,"2025":168},0.47,1.91,4.93,7.3,11.52,9.06,7.63,5.1,6.1,3.27,{"impactFactor":28,"impactFactorByYear":28,"i10Index":435,"i10IndexLast5Year":155,"totalPublication":130,"totalPublicationByYear":851,"totalCitation":852,"totalCitationByYear":853,"totalCitationPerPublication":860,"totalCitationPerPublicationByYear":861,"hindexLast5Year":136,"hindex":133},{"1017":40,"2015":40,"2016":123,"2017":42,"2018":42,"2019":40,"2020":45,"2022":123,"2023":123,"2024":40},3528,{"2014":323,"2015":140,"2016":201,"2017":158,"2018":522,"2019":613,"2020":854,"2021":855,"2022":701,"2023":856,"2024":857,"2025":858,"2026":859},280,403,436,525,589,366,176.4,{"2015":140,"2016":862,"2017":134,"2018":352,"2019":613,"2020":159,"2022":863,"2023":864,"2024":857},20.5,212.5,218,{"code":866,"data":867,"meta":28},"SUCCESS",{"id":868,"createTime":869,"updateTime":870,"relativeEntities":871,"slug":872,"properties":873,"entityType":25,"verifyStatus":882,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":883,"manageAffiliations":896,"indexDatabases":904,"url":28,"thumbnailPath":28,"statistic":918,"gsStatistic":28,"type":55,"analyzePriority":28},"d6c0257a-ce65-4515-865e-d8b69b4dae86","2024-04-06T00:19:55.657+00:00","2025-11-21T10:00:49.269+00:00",[],"Current-Gastroenterology-Reports",{"eissn":874,"issn":876,"title":878,"url":880},{"VOID":875},"15228037",{"VOID":877},"1534312X",{"EN":879},"Current Gastroenterology Reports",{"VOID":881},"https:\u002F\u002Flink.springer.com\u002Fjournal\u002F11894","PENDING",[884,890],{"id":885,"createTime":28,"updateTime":28,"relativeEntities":886,"label":887,"description":889,"parentId":28,"standard":28,"scholarHubFieldId":28},"a520f91c-9c10-4000-96b1-c80ea7776e25",[],{"EN":888},"Gastroenterology",{},{"id":891,"createTime":28,"updateTime":28,"relativeEntities":892,"label":893,"description":895,"parentId":28,"standard":28,"scholarHubFieldId":28},"0254e3e5-c28d-4a33-83da-81bc94d29ffd",[],{"EN":894},"Medicine (miscellaneous)",{},[897],{"id":898,"createTime":28,"updateTime":28,"relativeEntities":899,"slug":28,"properties":900,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":903,"statistic":28},"aeebfe70-bb47-4404-91bd-6d44079a5c1d",[],{"title":901},{"EN":902},"Current Medicine Group",[],[905],{"id":906,"indexDatabase":907,"url":912,"indexYears":913,"academicFieldIds":914,"indexDatabaseRanking":917},"dd3b4e65-a25f-46b3-9d16-53c0ca97d04a",{"id":786,"createTime":28,"updateTime":28,"relativeEntities":908,"label":909,"description":910,"key":792,"publicationTags":911,"standard":28},[],{"EN":789,"VI":789},{"EN":789,"VI":791},[794],"https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F28287","1999-2025",[915,916],"e89cebf4-fecf-4b74-8ab4-88fca891e4c2","d39aa686-8d5d-45f0-81c4-13c21a0f2f39","SCOPUS__Q2",{"impactFactor":32,"impactFactorByYear":919,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":920,"totalPublicationByYear":921,"totalCitation":32,"totalCitationByYear":922,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":923,"hindexLast5Year":32,"hindex":32},{},888,{"1996":40,"1999":196,"2000":139,"2001":142,"2002":150,"2003":200,"2004":280,"2005":152,"2006":352,"2007":150,"2008":208,"2009":139,"2010":279,"2011":132,"2012":278,"2013":139,"2014":147,"2015":136,"2016":352,"2017":148,"2018":132,"2019":147,"2020":69,"2021":146,"2022":51,"2023":142,"2024":45},{},{},{"meta":925,"data":927},{"total":926},"1195",[928,1029,1178,1253,1338,1424,1497,1611,1684,1800],{"id":929,"createTime":930,"updateTime":931,"relativeEntities":932,"slug":933,"properties":934,"entityType":943,"verifyStatus":882,"verifyTime":931,"verifyNote":944,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":945,"fullTextUrl":28,"authors":946,"publicationType":984,"publisherRelationship":985,"citationCount":28,"citationInfo":28,"publishDate":1025,"publishYear":1026,"citationAnalyzeStatus":882,"lastCitationAnalyze":28,"indexDatabases":1027,"openAccess":28,"references":28,"isForceReanalyzing":1028},"004a142d-ad91-49a8-8dbb-9f513ab38ec8","2024-01-14T19:27:12.619+00:00","2024-12-23T02:24:29.129+00:00",[],"Parasitic-infestations-of-the-biliary-tract",{"abstract":935,"title":937,"references":939,"doi":941},{"EN":936},"Parasitic infestations of the biliary tract are a common cause of biliary obstruction in tropical countries and can lead to such serious complications as cholangitis and cholangiocarcinoma. Endoscopic therapy has helped in the management of biliary complications caused by these parasites. Ascaris lumbricoides organisms, which normally reside in the jejunum, are actively motile and can invade the papilla, thus migrating into the bile duct and causing biliary obstruction. Endoscopic retrograde cholangiopancreatography is a useful diagnostic tool with potential for therapeutic management of biliary ascariasis. Infestation with Clonorchis sinensis organisms can cause such complications as intrahepatic stones, recurrent pyogenic cholangitis, cirrhosis, cholelithiasis, pancreatitis, and cholangiocarcinoma. Opisthorchis viverrini, Opisthorchis felineus, and Dicrocoelium dendriticum are closely related to C. sinensis and can also cause serious biliary complications. Fascioliasis, caused by Fasciola hepatica and F. gigantica, is a zoonotic helminthiasis that can present as acute hepatic or chronic biliary tract infection. CT, MRI, and ultrasound guidance are useful imaging tools for identifying these parasites and their complications.",{"EN":938},"Parasitic infestations of the biliary tract",{"VOID":940},"Delarocque Astagneau E, Hadengue A, Degott C, et al.: Biliary obstruction resulting from Strongyloides stercoralis infection. Report of a case. Gut 1994, 35:705–706.\nCrompton DWT, Nesheim MC, Pawlowski ZS. Ascariasis and Its Prevention and Control. London: Taylor and Frances; 1985.\nKhuroo MS: Ascariasis. Gastroenterol Clin N Am 1996, 25:553–577.\nOchoa B: Surgical complications of ascariasis. World J Surg 1991, 15:222–227\nPaul M: The movements of the adult Ascaris lumbricoides. Br J Surg 1972, 59:437–442.\nKhuroo MS, Zargar SA, Mahajan R: Hepatobiliary and pancreatic ascariasis in India. Lancet 1990, 335:1503–1506.\nKhuroo MS, Mahajan R, Zargar SA, et al.: Biliary and pancreatic ascariasis: A long term follow up. Natl Med J India 1989, 2:4–8\nKhuroo MS, Zargar SA: Biliary ascariasis: A common cause of biliary and pancreatic disease in endemic area. Gastroenterology 1985, 88:418–423.\nKamiya T, Morishita T, Peredo R, et al.: Duodenoscopic management in biliary ascariasis. Dig Endosc 1993, 5:179–182.\nSchulman A: Biliary ascariasis presenting in the United States. Am J Gastroenterol 1977, 68:167–170.\nManialawi MS, Khattar NY, Helmy MM, Burcharth F: Endoscopic diagnosis and extraction of biliary ascariasis. Endoscopy 1986, 18:204–205.\nMisra SP, Dwivedi M: Clinical features and management of biliary ascariasis in a non-endemic area. Postgrad Med J 2000, 76:29–32.\nKamiya T, Justiniano M, Duran A, Uechi C: Biliopancreatic ascariasis: endoscopic approach. J Gastroenterol 2002, 37(Suppl XIII), 97–99.\nSandouk F, Haffar S, Zada MM, et al.: Pancreatic-biliary ascariasis: experience of 300 cases. Am J Gastroenterol 1997, 92:2264–2267.\nWani NA, Shah OJ, Naqash SH: Postoperative biliary ascariasis: presentation and management experience. World J Surg 2000, 24:1143–1145.\nShah OJ, Zargar SA, Robbani I: Biliary ascariasis: a review. World J Surg 2006, 30:1500–1506.\nKhuroo MS, Zargar SA, Yattoo GN, et al.: Sonographic findings in gall bladder ascariasis. J Clin Ultrasound 1992, 20:587–591.\nShah OJ, Robanni I, Khan F, et al.: Management of biliary ascariasis in pregnancy. World J Surg 2005, 29:1294–1298.\nZargar SA, Khuroo MS: Management of biliary ascariasis in children. Indian J Gastroenterol 1990, 9:321.\nOsman M, Lausten SB, El-Sefi T, et al.: Biliary parasites. Dig Surg 1998, 15:287–296.\nWright RM, Dorrough RL, Ditmore HB: Ascariasis of the biliary system. Arch Surg 1963, 86:402–405.\nJavid G, Wani NA, Gulzar GM, et al.: Ascaris induced liver abscess. World J Surg 1999, 23:1191–1194.\nTeoh TB: A study of gallstones and included worms in recurrent pyogenic cholangitis. J Pathol Bacteriol 1963, 86:123–129.\nKhuroo MS, Zargar SA, Mahajan R, et al.: Sonographic appearances in biliary ascariasis. Gastroenterology 1987, 93:267–272.\nDesai S, Tobin K: Biliary ascariasis: Sonographic findings. AJR Am Roentgenol 1995, 164:767–8.\nKamath PS, Joseph DC, Chandran R, et al.: Biliary ascariasis: Ultrasonography, endoscopic retrograde cholangiopancreatography and biliary drainage. Gastroenterology 1986, 91:230–232.\nRocha Mde S, Costa NS, Costa JC, et al.: CT identification of ascariasis in the biliary tract. Abdom Imaging 1995, 20:317–319.\nNg KK, Wong HF, Kong MS, et al.: Biliary ascariasis, CT, MR cholangiopancreatography and navigator endoscopic appearance—report of a case of acute biliary obstruction. Abdom Imaging 1999, 24:470–472.\nDanaci M, Belet U, Polat V, Incesu L: MR imaging features of biliary ascariasis. AJR Am J Roentgenol 1999, 173:503.\nSriram PVJ, Tandon M, Rao GV, Reddy DN: Endoscopic ultrasound features of biliary ascariasis. Indian J Gastroenterol 2006, 25:50.\nKhuroo MS, Zargar SA, Yattoo GN, et al.: Worm extraction and biliary drainage in hepatobiliary and pancreatic ascariasis. Gastrointest Endosc 1993, 39:680–685.\nReddy DN, Sriram PV, Rao GV: Endoscopic diagnosis and management of tropical parasitic infestations. Gastrointest Endosc Clin N Am 2003, 13:765–773.\nMisra SP, Dwivedi M: Removal of Ascaris lumbricoides from the bile duct using balloon sphincteroplasty. Endoscopy 1998, 30:S6–S7.\nYoshihara S, Toyoki Y, Takahashi O, Sasaki M: Laparoscopic treatment for biliary ascariasis. Surg Laparosc Endosc Percut Tech 2000, 10:103–105.\nRim HJ: Clonorchiasis: an update. J Helminthol 2005, 79:269–281.\nOna FV, Dytoc JN: Clonorchis-associated cholangiocarcinoma: A report of two cases with unusual manifestations. Gastroenterology 1991, 101:831–839.\nHou PC: The pathology of Clonorchis sinensis infestation of the liver. J Pathol Bacteriol 1955, 70:53–64.\nHou PC: The relationship between primary carcinoma of the liver and infestation with Clonorchis sinensis. J Pathol Bacteriol 1956, 72:239–246.\nOng GB: A study of recurrent pyogenic cholangitis. Arch Surg 1962, 84:199–225.\nKim YI, Yu ES, Kim ST: Intraductal variant of peripheral cholangiocarcinoma of the liver with Clonorchis sinensis infection. Cancer 1989, 63:1562–1566.\nYong TS, Lee JS, Cho SN, et al.: A carbohydrate antigen of Clonorchis sinensis recognized by a species-specific monoclonal antibody. Korean J Parasitol 1996, 34:279–281.\nLeung JWC, Sung JY, Chung SCS, Metroweli C: Hepatic clonorchiasis: a study by endoscopic retrograde cholangiopancreatography. Gastrointest Endosc 1989, 35:226–231.\nChoi D, Hong ST, Lim JH, et al.: Sonographic findings of active Clonorchis sinensis infection. J Clin Ultrasound 2004, 32:17–23.\nChoi BI, Kim HJ, Han MC, et al.: CT findings of clonorchiasis. AJR Am J Roentgenol 1989, 152:281–284.\nJeong YY, Kang HK, Kim JW, et al.: MR imaging findings of clonorchiasis. Korean J Radiol 2004, 5:25–30.\nLeung JW, Sung JY, Banez VP, et al.: Endoscopic cholangio-pancreatography in hepatic clonorchiasis-a follow up study. Gastrointest Endosc 1990, 36:360–363.\nRim HJ, Lyu KS, Lee JS, JOO KH: Clinical evaluation of the therapeutic efficacy of Praziquantel (Embay 8440) against Clonorchis sinensis infection in man. Ann Trop Med Parasitol 1981, 75:27–33.\nMing-Gang C, Yiang-Jiu H, Zhan-ru W, et al.: Praziquantel in 237 cases of Clonorchis sinensis. Chin Med J 1983, 96:935–940.\nIARC: Infection with liver flukes Opisthorchis viverrini, Opisthorchis felineus and Clonorchis sinensis, IARC. Monogr Eval Carcinog Risks Hum 1994, 6:121–175.\nRim HJ: Opisthorchiasis. In Parasitic Zoonoses (Trematode Zoonoses), vol. 3. CRC Handbook Series in Zoonoses, Section C. Edited by Steel, JH. Boca Raton, FL: CRC Press; 1982:109–121.\nTansurat P: Opisthorchiasis. In Pathology of Protozoal and Helminthic Diseases. Edited by Marcial-Rojas RA. Baltimore: Williams and Wilkins; 1971:536–545.\nHarinasuta T, Riganti M, Bunnag D: Opisthorchis viverrini infection: pathogenesis and clinical features. Arzneimittelforschung 1984, 34:1167–1169.\nSripa B: Pathobiology of opisthorchiasis: an update. Acta Tropica 2003, 88:209–220.\nMairiang E, Mairiang P: Clinical manifestation of Opisthorchiasis and treatment. Acta Tropica 2003, 88:221–227.\nUpatham ES, Viyanant V: Opisthorchis viverrini and opisthorchiasis: a historical review and future perspective. Acta Tropica 2003, 88:171–176.\nElkins DB, Mairiang E, Sithithaworn P, et al.: Cross-sectional patterns of hepatobiliary abnormalities and possible precursor conditions of cholangiocarcinoma associated with Opisthorchis viverrini infection in humans. Am J Trop Med Hyg 1996, 55:295–301.\nMairiang, E, Hasswell-Elkins MR, et al.: Reversal of biliary tract abnormalities associated with Opisthorchis viverrini infection following praziquantel treatment. Trans R Soc Trop Med Hyg 1993, 87:194–197.\nArjona R, Riancho JA, Aguado JM, et al.: Fascioliasis in developed countries, a review of classic and aberrant forms of the disease. Medicine 1995, 74:13–23.\nPrice TA, Tuazon CU, Simon GL: Fascioliasis: case reports and review. Clin. Infect. Dis 1993, 17:426–430.\nLee OJ, Kim TH: Indirect evidence of ectopic pancreatic fascioliasis in human. J Gastroenterol Hepatol 2006, 21:1631–1633.\nAksoy DY, Kerimoglu U, Oto A, et al.: Fasciola hepatica infection: Clinical and computerized tomographic findings often patients. Turk J Gastroenterol 2006, 17:40–45.\nRivera-Marero CA, Santiago N, Hillyer GV: Evaluation of immunodiagnostic antigens in the excretory-secretory products of Fasciola hepatica. J Parasitol 1988, 74:646–652.\nVan Beers B, Pringot J, Guebel A, et al.: Hepatobiliary fascioliasis: noninvasive imaging findings. Radiology 1990, 174:809–810.\nHan JK, Choi BI, Cho JM, et al.: Ratiological findings of human fascioliasis. Abdom Imaging 1993, 18:261–264.\nCondomines J, Rene-Espinet JM, Espinoz-Perez JC, Vilardell F: Percutaneous cholangiography in the diagnosis of hepatic fascioliasis. Am J Gastroenterol 1985, 80:384–386.\nHauser SC, Bynum TE: Abnormalities on ERCP in a case of human fascioliasis. Gastrointest Endosc 1984, 30:80–82.\nSotoudehmanesh R, Yoonessi A: Diagnosis of Fasciola hepatica by endoscopic ultrasound. Endoscopy 2003, 35:1038.\nAcosta-Ferreira W, Vercelli-Retta J, Falconi LM: Fasciola hepatica human infection: histopathological study of sixteen cases. Virchows Arch A Pathol Anat Histol 1979, 383:319–327.\nDowidar N, El Sayad M, Osman M, Salem A: Endoscopic therapy of fascioliasis resistant to oral therapy. Gastrointest Endosc 1999, 50:345–351\nInal M, Doran F, Soyupak S, et al.: Percutaneous biliary drainage: an alternative treatment for biliary fascioliasis. Abdom Imaging 2002, 27:552–556.\nHaridy FM, Morsy TA, Ibrahim BB, Abdel-Aziz A: A preliminary study on dicrocoeliasis in Egypt, with a general review. J Egypt Soc Parasitol 2003, 33:85–96.\nMassoud A, Morsy TA, Haridy FM: Treatment of Egyptian dicrocoeliasis in man and animals with Mirazid. J Egypt Soc Parasitol 2003, 33:437–442.",{"VOID":942},"10.1007\u002Fs11894-007-0011-6","PUBLICATION","Author affiliation is blank","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs11894-007-0011-6",[947,955,970,977],{"id":948,"sortIndex":32,"researcher":28,"roles":949,"affiliations":951,"properties":952,"displayName":954,"givenName":28,"familyName":28},"dc2e7c2d-9f61-4873-a5bf-3ab6f3c499a3",[950],"AUTHOR",[],{"title":953},{"VI":954},"Surinder Singh Rana",{"id":956,"sortIndex":40,"researcher":28,"roles":957,"affiliations":958,"properties":967,"displayName":969,"givenName":28,"familyName":28},"aabe0f9c-fc5d-40b4-8335-59ad8510f6df",[950],[959],{"id":960,"sortIndex":32,"affiliation":961,"properties":28},"4b86a9ee-30a5-4bdb-8142-4646ff3efe39",{"id":960,"createTime":28,"updateTime":28,"relativeEntities":962,"slug":28,"properties":963,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":966,"statistic":28},[],{"title":964},{"VI":965},"Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India",[],{"title":968},{"VI":969},"Deepak Kumar Bhasin",{"id":971,"sortIndex":123,"researcher":28,"roles":972,"affiliations":973,"properties":974,"displayName":976,"givenName":28,"familyName":28},"4fa39ac9-e937-4864-b5f6-14d8120e471e",[950],[],{"title":975},{"VI":976},"Mohit Nanda",{"id":978,"sortIndex":42,"researcher":28,"roles":979,"affiliations":980,"properties":981,"displayName":983,"givenName":28,"familyName":28},"a8645800-8bca-4ab3-972d-95788a22b528",[950],[],{"title":982},{"VI":983},"Kartar Singh","ARTICLE",{"url":945,"publisher":986,"properties":1020},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":987,"slug":872,"properties":988,"entityType":25,"verifyStatus":882,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":992,"manageAffiliations":1001,"indexDatabases":1007,"url":28,"thumbnailPath":28,"statistic":1015,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":989,"title":990,"eissn":991},{"VOID":877},{"EN":879},{"VOID":875},[993,997],{"id":885,"createTime":28,"updateTime":28,"relativeEntities":994,"label":995,"description":996,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":888},{},{"id":891,"createTime":28,"updateTime":28,"relativeEntities":998,"label":999,"description":1000,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":894},{},[1002],{"id":898,"createTime":28,"updateTime":28,"relativeEntities":1003,"slug":28,"properties":1004,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1006,"statistic":28},[],{"title":1005},{"EN":902},[],[1008],{"id":906,"indexDatabase":1009,"url":912,"indexYears":913,"academicFieldIds":1014,"indexDatabaseRanking":917},{"id":786,"createTime":28,"updateTime":28,"relativeEntities":1010,"label":1011,"description":1012,"key":792,"publicationTags":1013,"standard":28},[],{"EN":789,"VI":789},{"EN":789,"VI":791},[794],[915,916],{"impactFactor":32,"impactFactorByYear":1016,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":920,"totalPublicationByYear":1017,"totalCitation":32,"totalCitationByYear":1018,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":1019,"hindexLast5Year":32,"hindex":32},{},{"1996":40,"1999":196,"2000":139,"2001":142,"2002":150,"2003":200,"2004":280,"2005":152,"2006":352,"2007":150,"2008":208,"2009":139,"2010":279,"2011":132,"2012":278,"2013":139,"2014":147,"2015":136,"2016":352,"2017":148,"2018":132,"2019":147,"2020":69,"2021":146,"2022":51,"2023":142,"2024":45},{},{},{"pages":1021,"volume":1023},{"VOID":1022},"156-164",{"VOID":1024},"9","2007-06-03",2007,[917],false,{"id":1030,"createTime":1031,"updateTime":1032,"relativeEntities":1033,"slug":1034,"properties":1035,"entityType":943,"verifyStatus":26,"verifyTime":1032,"verifyNote":1044,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1045,"fullTextUrl":28,"authors":1046,"publicationType":984,"publisherRelationship":1135,"citationCount":28,"citationInfo":28,"publishDate":1175,"publishYear":1176,"citationAnalyzeStatus":882,"lastCitationAnalyze":28,"indexDatabases":1177,"openAccess":28,"references":28,"isForceReanalyzing":1028},"004dc9c4-6c6e-48af-aad7-fea39ed40ba8","2024-01-15T12:20:41.837+00:00","2025-02-09T15:41:09.029+00:00",[],"Bugs-or-Drugs-Are-Probiotics-Safe-for-Use-in-the-Critically-Ill-",{"abstract":1036,"title":1038,"references":1040,"doi":1042},{"EN":1037},"Probiotics are living microorganisms which have demonstrated many benefits in prevention, mitigation, and treatment of various disease states in critically ill populations. These diseases include antibiotic-associated diarrhea, Clostridium difficile diarrhea, ventilator-associated pneumonia, clearance of vancomycin-resistant enterococci from the GI tract, pancreatitis, liver transplant, major abdominal surgery, and trauma. However, their use has been severely limited due to a variety of factors including a general naïveté within the physician community, lack of regulation, and safety concerns. This article focuses on uses for probiotics in prevention and treatment, addresses current concerns regarding their use as well as proposing a protocol for safe use of probiotics in the critically ill patient.",{"EN":1039},"Bugs or Drugs: Are Probiotics Safe for Use in the Critically Ill?",{"VOID":1041},"Boyle RJ, Robins-Browne RM, Tang MLK. Probiotic use in clinical practice: what are the risks? Am J Clin Nutr. 2006;83:1256–64.\nSnydman DR. The safety of probiotics. Clin Infect Dis. 2008;46:S104–11.\nReid G, Jass J, Sebulsky T, McCormick JK. Potential uses of probiotics in clinical practice. Clin Microbiol Rev. 2003;16:658–72.\nFood and Agricultural Organization of the United Nations\u002FWorld Health Organization. Guidelines for the evaluation of probiotics in food. Working group report 2002. Rome, Italy\u002FGeneva\u002FSwitzerland: FAO\u002FWHO; 2002.\nMartindale R, McClave S, Warren M, Desai S. Influence of the intestinal microbiota on the critically ill patient. In: Schiffrin EJ, Marteau P, Brassart P, editors. Intestinal microbiota in health and disease: modern concepts. 1st ed. Boca Raton: CRC Press; 2014. p. 293–306.\nMorrow LE, Gogineni V, Malesker MA. Probiotic, prebiotic and synbiotic use in critically ill patients. Curr Opin Crit Care. 2012;18:186–91.\nIsakow W, Morrow LE, Kollef MH. Probiotics for preventing and treating nosocomial infections. Chest. 2007;132:286–94.\nHempel S, Newberry SJ, Maher AR, et al. Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systemic review and meta-analysis. JAMA. 2012;307:1959–69.\nMcFarland LV. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol. 2006;101:812–22.\nMorrow LE, Gogineni V, Malesker MA. Probiotics in the intensive care unit. Nutr Clin Pract. 2012;27:235–41.\nSurawicz CM. Probiotics, antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in humans. Best Pract Res Clin Gastroenterol. 2003;17:775–83.\nTurroni F, Ventura M, Butto LF, et al. Molecular dialogue between the human gut microbiota and the host: a Lactobacillus and Bifidobacterium perspective. Cell Mol Life Sci. 2014;71:183–203.\nVidelock EJ, Cremonini F. Meta-analysis: probiotics in antibiotic-associated diarrhea. Aliment Pharmacol Ther. 2012;35:1355–69.\nMunoz P, Bouza E, Cuenca-Estrella M, et al. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis. 2005;40:1625–34.\nBouza E. Consequences of clostridium difficile infection: understanding the healthcare burden. Clin Microbiol Infect. 2012;18 Suppl 6:5–12.\nSafdar N, Maki DG. The commonality of risk factors for nosocomial colonization and infection with antimicrobial-resistant Staphylococcus aureus, enterococcus, gram-negative bacilli, Clostridium difficile, and Candida. Ann Intern Med. 2002;136(11):834–44.\nParkes GC, Sanderson JD, Whelan K. The mechanisms and efficacy of probiotics in the prevention of Clostridium difficile-associated diarrhea. Lancet Infect Dis. 2009;9:237–44.\nDendukuri N, Costa V, McGregor M, Brophy JM. Probiotic therapy for the prevention and treatment of Clostridium difficile-associated diarrhea: a systematic review. CMAJ. 2005;173:167–70.\nSegarra-Newnham M. Probiotics for Clostridium difficile-associated diarrhea: focus on Lactobacillus rhamnosus GG and Saccharomyces boulardii. Ann Pharmacother. 2007;41:1212–21.\nCasetagliuolo I, LaMont JT, Nikulasson ST, Pothoulakis C. Saccharomyces boulardii protease inhibits Clostridium difficile toxin A effects in the rat ileum. Infect Immun. 1996;64:5225–32.\nQamar A, Aboudola S, Warny M, et al. Saccharomyces boulardii stimulates intestinal immunoglobulin A immune response in Clostridium difficile toxin A in mice. Infect Immun. 2001;69:2762–5.\nTung JM, Dolovich LR, Lee CH. Prevention of Clostridium difficile infection with Saccharomyces boulardii: a systematic review. Can J Gastroenterol. 2009;23:817–21.\nGoldenberg JZ, Ma SSY, Saxton JD, MartzenMR, Vandvik PO, Thorlund K, Guyatt GH, Johnston BC. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database of Systematic Reviews 2013, Issue 5. Art. No.: CD006095. doi:10.1002\u002F14651858.CD006095.pub3. Cochrane review demonstrating the safety and efficacy of the combination of Lactobacillus acidophilus and Lactobacillus casei in the prevention of CDAD in patients who are not immunocompromised.\nJohnston BC, Ma SSY, Goldenberg JZ, et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea: a systematic review and meta-analysis. Ann Intern Med. 2012;157:878–88.\nAllen SJ, Wareham K, Wang D, et al. Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older patients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial. Lancet. 2013;382:1249–57. Large randomized, control trial suggesting there is no benefit when using L. acidophilus and B. bifidum in AAD and CDAD prevention, demonstrating the importance of using an appropriate strain when prescribing probiotics.\nVidal M, Forestier C, Charbonnel N, Henard S, Rabaud C, Lesens O. Probiotics and intestinal colonization by vancomycin-resistant enterococci in mice and humans. J Clin Microbiol. 2010;48:2595–8.\nManley KJ, Fraenkel MB, Mayall BC, Power DA. Probiotic treatment of vancomycin-resistant enterococci: a randomised controlled trial. Med J Aust. 2007;186:454–7.\nCook D. Ventilator associated pneumonia: perspectives on the burden of illness. Intensive Care Med. 2000;26:S31–7.\nCraven DE. Preventing ventilator-associated pneumonia in adults: sowing seeds of change. Chest. 2006;130:251–60.\nKollef MH. Prevention of hospital-associated pneumonia and ventilator associated pneumonia. Crit Care Med. 2004;32:1396–405.\nSachdev G, Napolitano LM. Postoperative pulmonary complications: pneumonia and acute respiratory failure. Surg Clin North Am. 2012;92:321–44. ix.\nKollef MH. What is ventilator-associated pneumonia and why is it important? Respir Care. 2005;506:714–21.\nHeineman J, Bubenik S, McClave S, Martindale R. Fighting fire with fire: is it time to use probiotics to manage pathogenic bacterial diseases? Curr Gastroenterol Rep. 2012;14:343–8.\nKollef MH, Shorr A, Tabak YP, Gupta V, Liu LZ, Johannes RS. Epidemiology and outcomes of healthcare-associated pneumonia: results from a large US database of culture-positive pneumonia. Chest. 2005;128:3854–62.\nKlarin B, Molin G, Jeppsson B, Larsson A. Use of the probiotic Lactobacillus plantarum 299 to reduce pathogenic bacteria in the oropharynx of intubated patients: a randomized controlled open pilot study. Crit Care. 2008;12:R136.\nBarraud D, Blard C, Hein F, et al. Probiotics in the critically ill patient: a double blind, randomized, placebo-controlled trial. Intensive Care Med. 2010;36:1540–7.\nSchultz MJ, Hass LE. Antibiotics or probiotics as preventative measures against ventilator-associated pneumonia: a literature review. Crit Care. 2011;15:R18.\nMorrow LE, Kollef MH, Casale TB. Probiotic prophylaxis of ventilator-associated pneumonia: a blinded, randomized, controlled trial. Am J Respir Crit Care Med. 2010;182:1058–64.\nSiempos II, Ntaidou TK, Falagas ME. Impact of the administration of probiotics on the incidence of ventilator-associated pneumonia: a meta-analysis of randomized controlled trials. Crit Care Med. 2010;38:954–62.\nPetrof EO, Dhaliwal R, Manzanares W, Johnstone J, Cook D, Heyland DK. Probiotics in the critically ill: a systematic review of the randomized trial evidence. Crit Care Med. 2012;40:3290–302. Meta-analysis of probiotic use in critically ill patients, demonstrated overall benefits of probiotics in reducing VAP and overall infectious complications. Heterogeneity of trials demonstrated need for more standardized assessment of the effects of probiotics to determine the true benefits.\nPillai A, Nelson RL. Probiotics for treatment of Clostridium difficile-associated colitis in adults. Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.: CD004611. doi:10.1002\u002F14651858.CD004611.pub2.\nMcFarland LV, Surawicz CM, Greenberg RN, et al. A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. JAMA. 1994;271:1913–8.\nSurawicz CM, McFarland LV, Greenberg RN, et al. The search for a better treatment for recurrent Clostridium difficile disease: use of high-dose vancomycin combined with Saccharomyces boulardii. Clin Infect Dis. 2000;31:1012–7.\nCapurso G, Marignani M, Piciucchi M, Merola E, Della FG. Probiotics and severe acute pancreatitis. J Clin Gastroenterol. 2008;42:S148–51.\nOláh A, Belágyi T, Isseekutz A, et al. Randomized clinical trial of specific lactobacillus and fiber supplement to early enteral nutrition in patients with acute pancreatitis. Br J Surg. 2002;89:1103–7.\nAkyol S, Mas MR, Comert B, et al. The effect of antibiotic and probiotic combination therapy on secondary pancreatic infections and oxidative stress parameters in experimental acute necrotizing pancreatitis. Pancreas. 2003;26:363–7.\nMuftuoglu MA, Isikgor S, Tosun S, Saglam A. Effects of probiotics on the severity of experimental acute pancreatitis. Eur J Clin Nutr. 2006;60:464–8.\nKaraken T, Ergun M, Dogan I, et al. Comparison of early enteral nutrition in severe acute pancreatitis with prebiotic fiber supplementation versus standard enteral solution: a prospective randomized double-blind study. World J Gastroenterol. 2007;13:2733–7.\nOláh A, Belágyi T, Pótó L, et al. Synbiotic control of inflammation and infection in severe acute pancreatitis: a prospective, randomized, double blind study. Hepatogastroenterology. 2007;54:590–4.\nVan Minnen LP, Timmerman HM, Lutgendorff F, et al. Modification of intestinal flora with multispecies probiotics reduces bacterial translocation and improves clinical course in a rat model of acute pancreatitis. Surgery. 2007;141:470–80.\nQin HL, Zheng JJ, Tong DN, et al. Effect of Lactobacillus plantarum enteral feeding on the gut permeability and septic complications in the patients with acute pancreatitis. Eur J Clin Nutr. 2008;62:923–30.\nWu XG, Zhang QC. Adjuvant therapy for probiotics in patients with severe acute pancreatitis with hepatic lesion: an analysis of 27 cases. Clin Med. 2009;29:51–2.\nSharma B, Srivastava S, Singh N, Sachdev V, Kapur S, Sarvana A. Role of probiotics on gut permeability and endotoxemia in patients with acute pancreatitis: a double-blind randomized controlled trial. J Clin Gastroenterol. 2011;45:442–8.\nHooijmans CR, de Vries RBM, Rovers MM, Gooszen HG, Ritskes-Hoitinga M. The effects of probiotic supplementation on experimental acute pancreatitis: a systematic review and meta-analysis. PLoS ONE. 2012;7(11):e48811. doi:10.1371\u002Fjournal.pone.0048811.\nWang G, Wen J, Xu L, et al. Effect of enteral nutrition and ecoimmunonutrition on bacterial translocation and cytokine production in patients with severe acute pancreatitis. J Surg Res. 2013;183:592–7.\nBesselink MGH, van Santvoort HC, Buskens E, et al. Probiotic prophylaxis in predicated severe acute pancreatitis: a randomized, double-blind, placebo-controlled trial. Lancet. 2008;371:651–9.\nSheldon T. Dutch probiotics study is criticized for its ‘design, approval and conduct’. BMJ. 2010;340:c77.\nRayes N, Hansen S, Seehofer D, et al. Early enteral supply of fiber and Lactobacilli versus conventional nutrition: a controlled trial in patients with major abdominal surgery. Nutrition. 2002;18:609–15.\nRayes N, Seehofer D, Theruvath T, et al. Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation—a randomized, double-blind trial. Am J Transplant. 2005;5:125–30.\nRayes N, Seehofer D, Hansen S, et al. Early enteral supply of Lactobacillus and fiber versus selective bowel decontamination: a controlled trial in liver transplant recipients. Transplantation. 2002;74:123–8.\nCorreia MITD, Nicoli JR. The role of probiotics in gastrointestinal surgery. Curr Opin Clin Nutr Metab Care. 2006;9:618–21.\nvan Santvoort HC, Besselink MG, Timmerman HM, van Minnen LP, Akkermans LM, Gooszen HG. Probiotics in surgery. Surgery. 2008;143:1–7.\nPitsouni E, Alexiou V, Saridakis V, Peppas G, Falagas ME. Does the use of probiotics\u002Fsynbiotics prevent postoperative infections in patients undergoing abdominal surgery? A meta-analysis of randomized controlled trials. Eur J Clin Pharmacol. 2009;65:561–70.\nJeppsson B, Mangell P, Thorlacius H. Use of probiotics as prophylaxis for postoperative infections. Nutrients. 2011;3:604–12.\nRayes N, Seehofer D, Theruvath T, et al. Effect of enteral nutrition and synbiotics on bacterial infection rates after pylorus-preserving pancreatoduodenectomy: a randomized, double-blind trial. Ann Surg. 2007;246:36–41.\nMcNaught CE, Woodcock NP, MacFie J, Mitchell CJ. A prospective randomised study of the probiotics Lactobacillus plantarum 299V on indices of gut barrier function in elective surgical patients. Gut. 2002;51:827–31.\nKotzampassi K, Giamarellos-Bourboulis EJ, Voudouris A, Kazamias P, Eleftheriadis E. Benefits of a synbiotic formula (Synbiotic 2000Forte®) in critically ill trauma patients: early results of a randomized controlled trial. World J Surg. 2006;30:1848–55.\nSpindler-Vesel A, Bengmark S, Vovk I, Cerovic O, Kompan L. Synbiotics, prebiotics, glutamine or peptide in early enteral nutrition: a randomized study in trauma patients. JPEN J Parenter Enteral Nutr. 2007;31:119–26.\nVenugopalan V, Shriner KA, Wong-Beringer A. Regulatory oversight and safety of probiotic use. Emerg Infect Dis. 2010;16:1661–5.\nHempel S, Newberry S, Ruelaz A, Wang Z, Miles JNV, Suttorp MJ, Johnsen B, Shanman R, Slusser W, Fu N, Smith A, Roth E, Polak J, Motala A, Perry T, Shekelle PG. Safety of probiotics to reduce risk and prevent or treat disease. Evidence Report\u002FTechnology Assessment No. 200. (Prepared by the Southern California Evidence-based Practice Center under Contract No. 290-2007-10062-I.) AHRQ Publication No. 11-E007. Rockville, MD: Agency for Healthcare Research and Quality. April 2011. Available at: www.ahrq.gov\u002Fclinic\u002Ftp\u002Fprobiotictp.htm. Systematic review conducted to determine the overall safety of probiotics in clinical trials. This review noted the need for more strains to be examined for efficacy in clinical trials as well as a lack of monitoring parameters used to determine efficacy and\u002For harm with the use of probiotics.\nMattia A, Merker R. Regulation of probiotic substances as ingredients in foods: premarket approval or “generally recognized as safe” notification. Clin Infect Dis. 2008;46:S115–8.\nCannon JP, Lee TA, Bolanos JT, Danziger LH. Pathogenic relevance of Lactobacillus: a retrospective review of over cases. Eur J Clin Microbiol Infect Dis. 2005;24:31–40.\nEnache-Angooulvant A, Hennequin C. Invasive Saccharomyces infection: a comprehensive review. Clin Infect Dis. 2005;41:1559–68.\nDrago L, Mattina R, De Vecchi E, Toscano M. Phenotypic and genotypic antibiotic resistance in some probiotics proposed for medical use. Int J Antimicrob Agents. 2013;41:393–401.\nCourvalin P. Antibiotic resistance: the pros and cons of probiotics. Dig Liver Dis. 2006;38:S261–5.\nHennequin C, Kauffmann-Lacroix C, Jobert A, et al. Possible role of catheters in Saccharomyces boulardii fungemia. Eur J Clin Microbiol Infect Dis. 2000;19:16–20.\nFloch MH, Walker WA, Madsen K, et al. Recommendations for probiotic use—2011 update. J Clin Gastroenterol. 2011;45:S168–71. Guidelines compiled on the use of probiotics including which probiotics have been tested in which disease states. This was an expansion on the original guidelines which were published three years earlier.\nCiorba MA. The gastroenterologist’s guide to probiotics. Clin Gastroenterol Hepatol. 2012;10:960–8.\nMcFarland LV. Systemic review and meta-analysis of Saccharomyces boulardii in adult patients. World J Gastroenterol. 2010;16:2202–22.\nWilliams NT. Probiotics. Am J Health Syst Pharm. 2010;67:449–58.",{"VOID":1043},"10.1007\u002Fs11894-014-0388-y","Auto Verify","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs11894-014-0388-y",[1047,1062,1075,1090,1105,1120],{"id":1048,"sortIndex":32,"researcher":28,"roles":1049,"affiliations":1050,"properties":1059,"displayName":1061,"givenName":28,"familyName":28},"e01e19fe-b006-4a59-9aa5-20f8925ee230",[950],[1051],{"id":1052,"sortIndex":32,"affiliation":1053,"properties":28},"cd0d2907-0caf-48d8-a7f8-3c675d255154",{"id":1052,"createTime":28,"updateTime":28,"relativeEntities":1054,"slug":28,"properties":1055,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1058,"statistic":28},[],{"title":1056},{"VI":1057},"Department of Pharmacy, University of Louisville Hospital, Louisville, USA",[],{"title":1060},{"VI":1061},"Lindsay M. Urben",{"id":1063,"sortIndex":40,"researcher":28,"roles":1064,"affiliations":1065,"properties":1072,"displayName":1074,"givenName":28,"familyName":28},"b3d6d3a1-a5bf-4adf-a8bc-1b506ff71eff",[950],[1066],{"id":1052,"sortIndex":32,"affiliation":1067,"properties":28},{"id":1052,"createTime":28,"updateTime":28,"relativeEntities":1068,"slug":28,"properties":1069,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1071,"statistic":28},[],{"title":1070},{"VI":1057},[],{"title":1073},{"VI":1074},"Jennifer Wiedmar",{"id":1076,"sortIndex":123,"researcher":28,"roles":1077,"affiliations":1078,"properties":1087,"displayName":1089,"givenName":28,"familyName":28},"8fbd4174-876f-4c78-bea6-14cdc7bc3655",[950],[1079],{"id":1080,"sortIndex":32,"affiliation":1081,"properties":28},"5deae9e5-d20e-4121-9314-aaf2929eedfe",{"id":1080,"createTime":28,"updateTime":28,"relativeEntities":1082,"slug":28,"properties":1083,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1086,"statistic":28},[],{"title":1084},{"VI":1085},"Division of Gastroenterology, Kaiser Permanente, San Diego, USA",[],{"title":1088},{"VI":1089},"Erica Boettcher",{"id":1091,"sortIndex":42,"researcher":28,"roles":1092,"affiliations":1093,"properties":1102,"displayName":1104,"givenName":28,"familyName":28},"f13debc1-b8a0-4fa3-8790-21570eb177d9",[950],[1094],{"id":1095,"sortIndex":32,"affiliation":1096,"properties":28},"f1d1a444-6287-44e5-b41d-e945b816b449",{"id":1095,"createTime":28,"updateTime":28,"relativeEntities":1097,"slug":28,"properties":1098,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1101,"statistic":28},[],{"title":1099},{"VI":1100},"Division of Pulmonary, Critical Care and Sleep Disorders, University of Louisville School of Medicine, Louisville, USA",[],{"title":1103},{"VI":1104},"Rodrigo Cavallazzi",{"id":1106,"sortIndex":45,"researcher":28,"roles":1107,"affiliations":1108,"properties":1117,"displayName":1119,"givenName":28,"familyName":28},"5cbd12cb-be2d-4a12-b46f-d03b31d3faa7",[950],[1109],{"id":1110,"sortIndex":32,"affiliation":1111,"properties":28},"8573fd4e-e325-4cf2-80de-4763d67092b7",{"id":1110,"createTime":28,"updateTime":28,"relativeEntities":1112,"slug":28,"properties":1113,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1116,"statistic":28},[],{"title":1114},{"EN":1115},"Department of Surgery, Oregon Health Sciences University, Portland, USA",[],{"title":1118},{"VI":1119},"Robert G. Martindale",{"id":1121,"sortIndex":46,"researcher":28,"roles":1122,"affiliations":1123,"properties":1132,"displayName":1134,"givenName":28,"familyName":28},"dae17171-8cfe-4027-a399-7cc6c902dcee",[950],[1124],{"id":1125,"sortIndex":32,"affiliation":1126,"properties":28},"29c00489-b534-4f3d-9fd7-df1ba77125c3",{"id":1125,"createTime":28,"updateTime":28,"relativeEntities":1127,"slug":28,"properties":1128,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1131,"statistic":28},[],{"title":1129},{"VI":1130},"Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville School of Medicine, Louisville, USA",[],{"title":1133},{"VI":1134},"Stephen A. McClave",{"url":1045,"publisher":1136,"properties":1170},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1137,"slug":872,"properties":1138,"entityType":25,"verifyStatus":882,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1142,"manageAffiliations":1151,"indexDatabases":1157,"url":28,"thumbnailPath":28,"statistic":1165,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1139,"title":1140,"eissn":1141},{"VOID":877},{"EN":879},{"VOID":875},[1143,1147],{"id":885,"createTime":28,"updateTime":28,"relativeEntities":1144,"label":1145,"description":1146,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":888},{},{"id":891,"createTime":28,"updateTime":28,"relativeEntities":1148,"label":1149,"description":1150,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":894},{},[1152],{"id":898,"createTime":28,"updateTime":28,"relativeEntities":1153,"slug":28,"properties":1154,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1156,"statistic":28},[],{"title":1155},{"EN":902},[],[1158],{"id":906,"indexDatabase":1159,"url":912,"indexYears":913,"academicFieldIds":1164,"indexDatabaseRanking":917},{"id":786,"createTime":28,"updateTime":28,"relativeEntities":1160,"label":1161,"description":1162,"key":792,"publicationTags":1163,"standard":28},[],{"EN":789,"VI":789},{"EN":789,"VI":791},[794],[915,916],{"impactFactor":32,"impactFactorByYear":1166,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":920,"totalPublicationByYear":1167,"totalCitation":32,"totalCitationByYear":1168,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":1169,"hindexLast5Year":32,"hindex":32},{},{"1996":40,"1999":196,"2000":139,"2001":142,"2002":150,"2003":200,"2004":280,"2005":152,"2006":352,"2007":150,"2008":208,"2009":139,"2010":279,"2011":132,"2012":278,"2013":139,"2014":147,"2015":136,"2016":352,"2017":148,"2018":132,"2019":147,"2020":69,"2021":146,"2022":51,"2023":142,"2024":45},{},{},{"pages":1171,"volume":1173},{"VOID":1172},"1-11",{"VOID":1174},"16","2014-07-03",2014,[917],{"id":1179,"createTime":1180,"updateTime":1181,"relativeEntities":1182,"slug":1183,"properties":1184,"entityType":943,"verifyStatus":26,"verifyTime":1181,"verifyNote":1044,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1193,"fullTextUrl":28,"authors":1194,"publicationType":984,"publisherRelationship":1210,"citationCount":28,"citationInfo":28,"publishDate":1250,"publishYear":1251,"citationAnalyzeStatus":882,"lastCitationAnalyze":28,"indexDatabases":1252,"openAccess":28,"references":28,"isForceReanalyzing":1028},"009078b0-ee09-4336-9495-e8c8396b6747","2024-02-02T10:34:40.121+00:00","2025-01-03T08:04:12.551+00:00",[],"Intestinal-Stem-Cells",{"abstract":1185,"title":1187,"references":1189,"doi":1191},{"EN":1186},"Self-renewal in the intestinal epithelia is fueled by a population of undifferentiated intestinal stem cells (ISCs) that give rise to daughter or progenitor cells, which can subsequently differentiate into the mature cell types required for normal gut function. The cellular signals that regulate self-renewal are poorly understood and the factors that mediate the transition from a stem cell to a progenitor cell in the gut are unknown. Recent studies have suggested that ISCs are located either at the crypt base interspersed between the Paneth cells (eg, Lgr-5+ve cells) or at or near position 4 within the intestinal crypt (eg, DCAMKL-1 or Bmi-1+ve cells). This raises the possibility that distinct stem cell regions exist in the crypts and that ISC’s state of activation will determine how the self-renewal is regulated in the intestinal tract.",{"EN":1188},"Intestinal Stem Cells",{"VOID":1190},"Crosnier C, Stamataki D, Lewis J: Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat Rev Genet 2006, 7:349–359.\nde Santa Barbara P, van den Brink GR, Roberts DJ: Development and differentiation of the intestinal epithelium. Cell Mol Life Sci 2003, 60:1322–1332.\nSchmidt GH, Winton DJ, Ponder BA: Development of the pattern of cell renewal in the crypt-villus unit of chimeric mouse small intestine. Development 1988, 103:785–790.\nCheng H, Leblond CP: Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types. Am J Anat 1974, 141:537–561.\nWright NA: Epithelial stem cell repertoire in the gut: clues to the origin of cell lineages, proliferative units and cancer. Int J Exp Pathol 2000, 81:117–143.\nPotten CS, Loeffler M: Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 1990, 110:1001–1020.\nGordon JI, Schmidt GH, Roth KA: Studies of intestinal stem cells using normal, chimeric, and transgenic mice. FASEB J 1992, 6:3039–3050.\nPotten CS: Stem cells in gastrointestinal epithelium: numbers, characteristics and death. Philos Trans R Soc Lond B Biol Sci 1998, 353:821–830.\nBjerknes M, Cheng H: The stem-cell zone of the small intestinal epithelium. I. Evidence from Paneth cells in the adult mouse. Am J Anat 1981, 160:51–63.\nBlanpain C, Horsley V, Fuchs E: Epithelial stem cells: turning over new leaves. Cell 2007,128:445–458.\nMoore KA, Lemischka IR: Stem cells and their niches. Science 2006, 311:1880–1885.\nKorinek V, Barker N, Moerer P, et al.: Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 1998, 19:379–383.\nKim BM, Mao J, Taketo MM, et al.: Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. Gastroenterology 2007, 133:529–538.\nvan de Wetering M, Sancho E, Verweij C, et al.: The β-catenin\u002FTCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 2002, 111:241–250.\nGregorieff A, Pinto D, Begthel H, et al.: Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology 2005, 129:626–638.\nByun T, Karimi M, Marsh JL, et al.: Expression of secreted Wnt antagonists in gastrointestinal tissues: potential role in stem cell homeostasis. J Clin Pathol 2005, 58:515–519.\nMadison BB, Braunstein K, Kuizon E, et al.: Epithelial hedgehog signals pattern the intestinal crypt-villus axis. Development 2005, 132:279–289.\nBitgood MJ, McMahon AP: Hedgehog and Bmp genes are co-expressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol 1995, 172:126–138.\n• Zacharias WJ, Li X, Madison BB, et al.: Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propria. Gastroenterology 2010, 138:2368–2377. This article investigates the effects of chronic Hedgehog (Hh) inhibition in vivo by profiling molecular pathways acutely modulated by Hh signaling in the intestinal mesenchyme.\nHe XC, Zhang J, Tong WG, et al.: BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signaling. Nat Genet 2004, 36:1117–1121.\nHaramis AP, Begthel H, van den Born M, et al.: De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science 2004, 303:1684–1686.\nLouvi A, Artavanis-Tsakonas S: Notch signaling in vertebrate neural development. Nat Rev Neurosci 2006, 7:93–102.\nChiba S: Notch signaling in stem cell systems. Stem Cells 2006, 24:2437–2447.\nFortini ME: Gamma-secretase-mediated proteolysis in cell-surface-receptor signaling. Nat Rev Mol Cell Biol 2002, 3:673–684.\nKao HY, Ordentlich P, Koyano-Nakagawa N, et al.: A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev 1998, 12:2269–2277.\nLai EC: Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins. EMBO Rep 2002, 3:840–845.\nIso T, Kedes L, Hamamori Y: HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol 2003, 194:237–255.\nFre S, Huyghe M, Mourikis P, et al.: Notch signals control the fate of immature progenitor cells in the intestine. Nature 2005, 435:964–968.\nvan der Flier LG, Clevers H: Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol 2008, 71:241–260.\nPotten CS: Extreme sensitivity of some intestinal crypt cells to X and gamma irradiation. Nature 1977, 269:518–521.\nPotten CS, Owen G, Booth D: Intestinal stem cells protect their genome by selective segregation of template DNA strands. J Cell Sci 2002, 115:2381–2388.\nWinton DJ, Blount MA, Ponder BAJ: A clonal marker induced by mutation in mouse intestinal epithelium. Nature 1988, 333:463–466.\nHe XC, Yin T, Grindley JC, et al.: PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat Genet 2007, 39:189–198.\nBarker N, van de Wetering M, Clevers H: The intestinal stem cell. Genes Dev 2008, 22:1856–1864.\nScoville DH, Sato T, He XC, et al.: Current view: intestinal stem cells and signaling. Gastroenterology 2008, 134:849–864.\nBjerknes M, Cheng H: Clonal analysis of mouse intestinal epithelial progenitors. Gastroenterology 1999, 116:7–14.\nBatlle E, Henderson JT, Beghtel H, et al.: Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB\u002FephrinB. Cell 2002, 111:251–263.\nWielenga VJ, Smits R, Korinek V, et al.: Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am J Pathol 1999, 154:515–523.\nKayahara T, Sawada M, Takaishi S, et al.: Candidate markers for stem and early progenitor cells, Musashi-1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine. FEBS Lett 2003, 535:131–135.\nPotten CS, Booth C, Tudor GL, et al.: Identification of a putative intestinal stem cell and early lineage marker musashi-1. Differentiation 2003, 71:28–41.\nTian Q, Feetham MC, Tao WA, et al.: Proteomic analysis identifies that 14-3-3zeta interacts with beta-catenin and facilitates its activation by Akt. Proc Natl Acad Sci U S A 2004, 101:15370–15375.\nDekaney CM, Rodriguez JM, Graul MC, et al.: Isolation and characterization of a putative intestinal stem cell fraction from mouse jejunum. Gastroenterology 2005, 129:1567–1580.\nGulati AS, Ochsner SA, Henning SJ: Molecular properties on side population-sorted cells from mouse small intestine. Am J Physiol Gastrointest Liver Physiol 2008, 294:G286–G294.\nVidrich A, Buzan JM, Ilo C, et al.: Fibroblast growth factor receptor-3 is expressed in undifferentiated intestinal epithelial cells during murine crypt morphogenesis. Dev Dyn 2004, 230:114–123.\nBlache P, van de Wetering M, Duluc I, et al.: SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J Cell Biol 2004, 166:37–47.\nVan der Flier LG, Sabates-Bellver J, Oving I, et al.: The intestinal Wnt\u002FTCF signature. Gastroenterology 2007, 132:628–632.\nBreault DT, Min IM, Carlone DL, et al.: Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proc Natl Acad Sci U S A 2008, 105:10420–10425.\nStappenbeck TS, Mills JC, Gordon JI: Molecular features of adult mouse small intestinal epithelial progenitors. Proc Natl Acad Sci U S A 2003, 100:1004–1009.\nGiannakis M, Stappenbeck TS, Mills JC, et al.: Molecular properties of adult mouse gastric and intestinal epithelial progenitors in their niches. J Biol Chem 2006, 281:11292–11300.\nPotten CS, Booth C, Pritchard DM: The intestinal epithelial stem cell: the mucosal governor. Int J Exp Pathol 1997, 78:219–243.\n•• Barker N, van Es JH, Kuipers J, et al.: Identification of stem cells in small intestine and colon by marker gene LGR5. Nature 2007, 449:1003–1008. Using knock-in alleles, this elegant study identifies stem cells in small intestine and colon by marker gene Lgr5.\nPotten CS, Gandara R, Mahida YR, et al.: The stem cells of small intestinal crypts: where are they? Cell Prolif 2009, 42:731–750.\nZhu L, Gibson P, Currle DS, Tong Y, et al.: Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature 2009, 457:603–607.\nvan der Flier LG, Haegebarth A, Stange DE, et al.: OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. Gastroenterology 2009, 137:15–17.\n•• Sangiorgi E, Capecchi MR: Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet 2008, 40:915–920. Using a mouse expressing a tamoxifen-inducible Cre from the Bmi1 locus, this study identifies Bmi1 as an ISC marker in vivo.\n•• May R, Riehl TE, Hunt C, et al.: Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli\u002Fmultiple intestinal neoplasia mice. Stem Cells 2008, 26:630–637. Using the radiation injury and APC\u002FMin mouse models, this study identifies DCAMKL-1 as an ISC marker in vivo.\nGiannakis M, Chen SL, Karam SM, et al.: Helicobacter pylori evolution during progression from chronic atrophic gastritis to gastric cancer and its impact on gastric stem cells. Proc Natl Acad Sci U S A 2008, 105:4358–4363.\n• May R, Sureban SM, Hoang N, et al.: Doublecortin and CaM kinase-like-1 and leucine-rich-repeat-containing G-protein-coupled receptor mark quiescent and cycling intestinal stem cells, respectively. Stem Cells 2009, 27:2571–2579. Using the modified label-retention assay, this study compares the quiescent versus actively cycling nature of the intestinal stem markers DCAMKL-1 and Lgr5, respectively.\nPotten CS: A comprehensive study of the radiobiological response of the murine (BDF1) small intestine. Int J Rad Biol 1990, 58:925–973.\nPizarro TT, Arseneau KO, Cominelli F: Lessons from genetically engineered animal models XI. Novel mouse models to study pathogenic mechanisms of Crohn’s disease. Am J Physiol 2000, 278:G665–G669.\nJobin C, Sartor RB: The I kappa B\u002FNF-kappa B system: a key determinant of mucosal inflammation and protection. Am J Physiol 2000, 278:C451–C462.\nKarin M: Nuclear factor-κB in cancer development and progression. Nature 2006, 441:431–436.\nWehkamp J, Wang G, Kubler I, et al.: The Paneth cell alpha defensin deficiency of ileal Crohn’s disease is linked to Wnt\u002FTcf-4. J Immunol 2007, 179:3109–3118.\nRiehl T, Cohn S, Tessner T, et al.: Lipopolysaccharide is radioprotective in the mouse intestine through a prostaglandin-mediated mechanism. Gastroenterology 2000, 118:1106–1116.\nHouchen CW, George RJ, Sturmoski MA, et al.: FGF-2 enhances intestinal stem cell survival and its expression is induced after radiation injury. Am J Physiol 1999, 276:G249–G258.\nWu S, Miyamoto T: Radioprotection of the intestinal crypts of mice by recombinant human interlukin-1. Radiat Res 1990, 123:112–115.\nSomosy Z, Horvath G, Telbisz A, et al.: Morphological aspects of ionizing radiation response of small intestine. Micron 2002, 33:167–178.",{"VOID":1192},"10.1007\u002Fs11894-010-0130-3","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs11894-010-0130-3",[1195],{"id":1196,"sortIndex":32,"researcher":28,"roles":1197,"affiliations":1198,"properties":1207,"displayName":1209,"givenName":28,"familyName":28},"9b7f441c-5db2-4d63-a7d7-af06fd3af68c",[950],[1199],{"id":1200,"sortIndex":32,"affiliation":1201,"properties":28},"9fd854c4-24d1-46ed-adbc-58576fef8abb",{"id":1200,"createTime":28,"updateTime":28,"relativeEntities":1202,"slug":28,"properties":1203,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1206,"statistic":28},[],{"title":1204},{"VI":1205},"Department of Internal Medicine, Division of Digestive Diseases, University of Oklahoma Health Sciences Center, Oklahoma City, USA",[],{"title":1208},{"VI":1209},"Shahid Umar",{"url":1193,"publisher":1211,"properties":1245},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1212,"slug":872,"properties":1213,"entityType":25,"verifyStatus":882,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1217,"manageAffiliations":1226,"indexDatabases":1232,"url":28,"thumbnailPath":28,"statistic":1240,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1214,"title":1215,"eissn":1216},{"VOID":877},{"EN":879},{"VOID":875},[1218,1222],{"id":885,"createTime":28,"updateTime":28,"relativeEntities":1219,"label":1220,"description":1221,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":888},{},{"id":891,"createTime":28,"updateTime":28,"relativeEntities":1223,"label":1224,"description":1225,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":894},{},[1227],{"id":898,"createTime":28,"updateTime":28,"relativeEntities":1228,"slug":28,"properties":1229,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1231,"statistic":28},[],{"title":1230},{"EN":902},[],[1233],{"id":906,"indexDatabase":1234,"url":912,"indexYears":913,"academicFieldIds":1239,"indexDatabaseRanking":917},{"id":786,"createTime":28,"updateTime":28,"relativeEntities":1235,"label":1236,"description":1237,"key":792,"publicationTags":1238,"standard":28},[],{"EN":789,"VI":789},{"EN":789,"VI":791},[794],[915,916],{"impactFactor":32,"impactFactorByYear":1241,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":920,"totalPublicationByYear":1242,"totalCitation":32,"totalCitationByYear":1243,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":1244,"hindexLast5Year":32,"hindex":32},{},{"1996":40,"1999":196,"2000":139,"2001":142,"2002":150,"2003":200,"2004":280,"2005":152,"2006":352,"2007":150,"2008":208,"2009":139,"2010":279,"2011":132,"2012":278,"2013":139,"2014":147,"2015":136,"2016":352,"2017":148,"2018":132,"2019":147,"2020":69,"2021":146,"2022":51,"2023":142,"2024":45},{},{},{"pages":1246,"volume":1248},{"VOID":1247},"340-348",{"VOID":1249},"12","2010-08-04",2010,[917],{"id":1254,"createTime":1255,"updateTime":1256,"relativeEntities":1257,"slug":1258,"properties":1259,"entityType":943,"verifyStatus":26,"verifyTime":1256,"verifyNote":1044,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1270,"fullTextUrl":28,"authors":1271,"publicationType":984,"publisherRelationship":1300,"citationCount":28,"citationInfo":28,"publishDate":1335,"publishYear":1336,"citationAnalyzeStatus":882,"lastCitationAnalyze":28,"indexDatabases":1337,"openAccess":28,"references":28,"isForceReanalyzing":1028},"00cc5b8f-c1b1-4d3f-93d6-4256ce81771f","2024-04-06T17:56:10.728+00:00","2025-01-02T00:53:32.039+00:00",[],"Esophagogastric-Junction-Outflow-Obstruction-EGJOO-A-Manometric-Phenomenon-or-Clinically-Impactful-Problem",{"abstract":1260,"title":1262,"keywords":1264,"references":1266,"doi":1268},{"EN":1261},"Esophagogastric junction outflow obstruction (EGJOO), defined manometrically by impaired esophagogastric junction relaxation (EGJ) with preserved peristalsis, can be artifactual, due to secondary etiologies (mechanical, medication-induced), or a true motility disorder. The purpose of this review is to go over the evolving approach to diagnosing and treating clinically relevant EGJOO. Timed barium esophagram (TBE) and the functional lumen imaging probe (FLIP) are useful to identify clinically relevant EGJOO that merits lower esophageal sphincter (LES) directed therapies. There are no randomized controlled trials evaluating EJGOO treatment. Uncontrolled trials show effectiveness for pneumatic dilation and peroral endoscopic myotomy to treat confirmed EGJOO; Botox and Heller myotomy may also be considered but data for confirmed EGJOO is more limited. Diagnosis of clinically relevant idiopathic EGJOO requires symptoms, exclusion of mechanical and medication-related etiologies, and confirmation of EGJ obstruction by TBE or FLIP. Botox LES injection has limited durability, it can be used in patients who are not candidates for other treatments. PD and POEM are effective in confirmed EGJOO, Heller myotomy may also be considered but data for confirmed EGJOO is limited. Randomized controlled trials are needed to clarify optimal management of EGJOO.",{"EN":1263},"Esophagogastric Junction Outflow Obstruction (EGJOO): A Manometric Phenomenon or Clinically Impactful Problem",{"EN":1265},"",{"VOID":1267},"Yadlapati R, Kahrilas PJ, Fox MR, Bredenoord AJ, PrakashGyawali C, Roman S, et al. Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0(©). Neurogastroenterol Motil. 2021;33(1):e14058. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fnmo.14058.\nKahrilas PJ, Bredenoord AJ, Fox M, Gyawali CP, Roman S, Smout AJ, et al. The Chicago Classification of esophageal motility disorders v3.0. Neurogastroenterol Motil. 2015;27(2):160–74. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fnmo.12477.\nBeveridge CA, Triggs JR, Thanawala SU, Ahuja NK, Falk GW, Benitez AJ, et al. Can FLIP guide therapy in idiopathic esophagogastric junction outflow obstruction? Dis Esophagus. 2022;35(4):doab077. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fdote\u002Fdoab077.\nBeveridge C, Lynch K. Diagnosis and Management of Esophagogastric Junction Outflow Obstruction. Gastroenterol Hepatol (N Y). 2020;16(3):131–8.\nPatel DA, Yadlapati R, Vaezi MF. Esophageal Motility Disorders: Current Approach to Diagnostics and Therapeutics. Gastroenterology. 2022;162(6):1617–34. https:\u002F\u002Fdoi.org\u002F10.1053\u002Fj.gastro.2021.12.289.\nBredenoord AJ, Babaei A, Carlson D, Omari T, Akiyama J, Yadlapati R, et al. Esophagogastric junction outflow obstruction. Neurogastroenterol Motil. 2021;33(9): e14193. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fnmo.14193.\nZikos TA, Triadafilopoulos G, Clarke JO. Esophagogastric Junction Outflow Obstruction: Current Approach to Diagnosis and Management. Curr Gastroenterol Rep. 2020;22(2):9. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11894-020-0743-0.\nLiu A, Woo M, Nasser Y, Gupta M, Buresi MC, Curley M, et al. Esophagogastric junction outflow obstruction on manometry: Outcomes and lack of benefit from CT and EUS. Neurogastroenterol Motil. 2019;31(12): e13712. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fnmo.13712.\nSnyder DL, Vela MF. Impact of opioids on esophageal motility. Neurogastroenterol Motil. 2023;35(5): e14587. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fnmo.14587.\nMisselwitz B, Hollenstein M, Bütikofer S, Ang D, Heinrich H, Fox M. Prospective serial diagnostic study: the effects of position and provocative tests on the diagnosis of oesophageal motility disorders by high-resolution manometry. Aliment Pharmacol Ther. 2020;51(7):706–18. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fapt.15658.\nTriggs JR, Carlson DA, Beveridge C, Jain A, Tye MY, Kahrilas PJ, et al. Upright Integrated Relaxation Pressure Facilitates Characterization of Esophagogastric Junction Outflow Obstruction. Clin Gastroenterol Hepatol. 2019;17(11):2218-26.e2. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.cgh.2019.01.024.\nKahrilas PJ, Carlson DA, Pandolfino JE. Advances in the Diagnosis and Management of Achalasia and Achalasia-Like Syndromes: Insights From HRM and FLIP. Gastro Hep Adv. 2023;2(5):701–10. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.gastha.2023.02.001.\nde Oliveira JM, Birgisson S, Doinoff C, Einstein D, Herts B, Davros W, et al. Timed barium swallow: a simple technique for evaluating esophageal emptying in patients with achalasia. AJR Am J Roentgenol. 1997;169(2):473–9. https:\u002F\u002Fdoi.org\u002F10.2214\u002Fajr.169.2.9242756.\nBlonski W, Kumar A, Feldman J, Richter JE. Timed Barium Swallow: Diagnostic Role and Predictive Value in Untreated Achalasia, Esophagogastric Junction Outflow Obstruction, and Non-Achalasia Dysphagia. Am J Gastroenterol. 2018;113(2):196–203. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fajg.2017.370.\nClayton SB, Shin CM, Ewing A, Blonski W, Richter J. Pneumatic dilation improves esophageal emptying and symptoms in patients with idiopathic esophago-gastric junction outflow obstruction. Neurogastroenterol Motil. 2019;31(3): e13522. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fnmo.13522.\nSavarino E, di Pietro M, Bredenoord AJ, Carlson DA, Clarke JO, Khan A, et al. Use of the Functional Lumen Imaging Probe in Clinical Esophagology. Am J Gastroenterol. 2020;115(11):1786–96. https:\u002F\u002Fdoi.org\u002F10.14309\u002Fajg.0000000000000773.\nTriggs JR, Carlson DA, Beveridge C, Kou W, Kahrilas PJ, Pandolfino JE. Functional Luminal Imaging Probe Panometry Identifies Achalasia-Type Esophagogastric Junction Outflow Obstruction. Clin Gastroenterol Hepatol. 2020;18(10):2209–17. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.cgh.2019.11.037.\nCarlson DA, Schauer JM, Kou W, Kahrilas PJ, Pandolfino JE. Functional Lumen Imaging Probe Panometry Helps Identify Clinically Relevant Esophagogastric Junction Outflow Obstruction per Chicago Classification v4.0. Am J Gastroenterol. 2023;118(1):77–86. https:\u002F\u002Fdoi.org\u002F10.14309\u002Fajg.0000000000001980.\nKhashab MA, Familiari P, Draganov PV, Aridi HD, Cho JY, Ujiki M, et al. Peroral endoscopic myotomy is effective and safe in non-achalasia esophageal motility disorders: an international multicenter study. Endosc Int Open. 2018;6(8):E1031–6. https:\u002F\u002Fdoi.org\u002F10.1055\u002Fa-0625-6288.\nMarin I, Serra J. Patterns of esophageal pressure responses to a rapid drink challenge test in patients with esophageal motility disorders. Neurogastroenterol Motil. 2016;28(4):543–53. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fnmo.12749.\nKrause AJ, Su H, Triggs JR, Beveridge C, Baumann AJ, Donnan E, et al. Multiple rapid swallows and rapid drink challenge in patients with esophagogastric junction outflow obstruction on high-resolution manometry. Neurogastroenterol Motil. 2021;33(3): e14000. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fnmo.14000.\nShaker A, Stoikes N, Drapekin J, Kushnir V, Brunt LM, Gyawali CP. Multiple rapid swallow responses during esophageal high-resolution manometry reflect esophageal body peristaltic reserve. Am J Gastroenterol. 2013;108(11):1706–12. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fajg.2013.289.\nDodds WJ, Stewart ET, Kishk SM, Kahrilas PJ, Hogan WJ. Radiologic amyl nitrite test for distinguishing pseudoachalasia from idiopathic achalasia. AJR Am J Roentgenol. 1986;146(1):21–3. https:\u002F\u002Fdoi.org\u002F10.2214\u002Fajr.146.1.21.\nMayrand S, Diamant NE. Measurement of human esophageal tone in vivo. Gastroenterology. 1993;105(5):1411–20. https:\u002F\u002Fdoi.org\u002F10.1016\u002F0016-5085(93)90146-4.\nGonzález M, Mearin F, Vasconez C, Armengol JR, Malagelada JR. Oesophageal tone in patients with achalasia. Gut. 1997;41(3):291–6. https:\u002F\u002Fdoi.org\u002F10.1136\u002Fgut.41.3.291.\nBabaei A, Shad S, Szabo A, Massey BT. Pharmacologic interrogation of patients with esophagogastric junction outflow obstruction using amyl nitrite. Neurogastroenterol Motil. 2019;31(9): e13668. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fnmo.13668.\nBabaei A, Szabo A, Shad S, Massey BT. Chronic daily opioid exposure is associated with dysphagia, esophageal outflow obstruction, and disordered peristalsis. Neurogastroenterol Motil. 2019;31(7): e13601. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fnmo.13601.\nSnyder DL, Vela MF. Opioid-induced esophageal dysfunction. Curr Opin Gastroenterol. 2020;36(4):344–50. https:\u002F\u002Fdoi.org\u002F10.1097\u002Fmog.0000000000000648.\nRavi K, Murray JA, Geno DM, Katzka DA. Achalasia and chronic opioid use: innocent bystanders or associated conditions? Dis Esophagus. 2016;29(1):15–21. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fdote.12291.\nJacobs CC, Al-Haddad M, Stainko S, Perkins A, DeWitt JM. Prevalence and impact of opioid use in patients undergoing peroral endoscopic myotomy. Gastrointest Endosc. 2023;97(4):655-63.e2. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.gie.2022.12.006.\nLynch KL, Yang YX, Metz DC, Falk GW. Clinical presentation and disease course of patients with esophagogastric junction outflow obstruction. Dis Esophagus. 2017;30(6):1–6. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fdote\u002Fdox004.\nGarbarino S, von Isenburg M, Fisher DA, Leiman DA. Management of Functional Esophagogastric Junction Outflow Obstruction: A Systematic Review. J Clin Gastroenterol. 2020;54(1):35–42. https:\u002F\u002Fdoi.org\u002F10.1097\u002Fmcg.0000000000001156.\nScherer JR, Kwiatek MA, Soper NJ, Pandolfino JE, Kahrilas PJ. Functional esophagogastric junction obstruction with intact peristalsis: a heterogeneous syndrome sometimes akin to achalasia. J Gastrointest Surg. 2009;13(12):2219–25. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11605-009-0975-7.\nSalvador R, Provenzano L, Nezi G, Capovilla G, Nicoletti L, Pierobon ES, et al. Laparoscopic Heller-Dor Is an Effective Treatment for Esophageal-Gastric Junction Outflow Obstruction. J Gastrointest Surg. 2021;25(9):2201–7. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11605-021-05021-1.\nClayton SB, Patel R, Richter JE. Functional and Anatomic Esophagogastic Junction Outflow Obstruction: Manometry, Timed Barium Esophagram Findings, and Treatment Outcomes. Clin Gastroenterol Hepatol. 2016;14(6):907–11. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.cgh.2015.12.041.\nPérez-Fernández MT, Santander C, Marinero A, Burgos-Santamaría D, Chavarría-Herbozo C. Characterization and follow-up of esophagogastric junction outflow obstruction detected by high resolution manometry. Neurogastroenterol Motil. 2016;28(1):116–26. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fnmo.12708.\nDesai N, Kline M, Duncan D, Godiers M, Patel V, Keilin S, et al. Expanding the role of pneumatic dilation for nonachalasia patients: a comparative study. Gastrointest Endosc. 2023;97(2):251–9. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.gie.2022.09.032.\nOkeke FC, Raja S, Lynch KL, Dhalla S, Nandwani M, Stein EM, et al. What is the clinical significance of esophagogastric junction outflow obstruction? evaluation of 60 patients at a tertiary referral center. Neurogastroenterol Motil. 2017;29(6). https:\u002F\u002Fdoi.org\u002F10.1111\u002Fnmo.13061.\nIchkhanian Y, Sanaei O, Canakis A, Vosoughi K, Almazan E, Ghandour B, et al. Esophageal peroral endoscopic myotomy (POEM) for treatment of esophagogastric junction outflow obstruction: results from the first prospective trial. Endosc Int Open. 2020;8(9):E1137–43. https:\u002F\u002Fdoi.org\u002F10.1055\u002Fa-1198-4643.\nSanaka M, Kumar P, Mohammed A, Sudarshan M, Murthy S, Raja S. Efficacy of Peroral Endoscopic Myotomy for the Treatment of Functional Esophagogastric Junction Outflow Obstruction. iGIE. 2023;2(4):467–71. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.igie.2023.08.003.",{"VOID":1269},"10.1007\u002Fs11894-024-00928-6","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs11894-024-00928-6",[1272,1287],{"id":1273,"sortIndex":32,"researcher":28,"roles":1274,"affiliations":1275,"properties":1284,"displayName":1286,"givenName":28,"familyName":28},"3487db2b-fad0-4c06-9de4-7425ef243fd5",[950],[1276],{"id":1277,"sortIndex":32,"affiliation":1278,"properties":28},"25f7e158-53fd-402f-a452-a262879431bb",{"id":1277,"createTime":28,"updateTime":28,"relativeEntities":1279,"slug":28,"properties":1280,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1283,"statistic":28},[],{"title":1281},{"VI":1282},"Mayo Clinic Arizona, Scottsdale, USA",[],{"title":1285},{"VI":1286},"Laura Bach",{"id":1288,"sortIndex":40,"researcher":28,"roles":1289,"affiliations":1290,"properties":1297,"displayName":1299,"givenName":28,"familyName":28},"a69354f3-2c5a-43b7-b4f3-5ee2722d50a3",[950],[1291],{"id":1277,"sortIndex":32,"affiliation":1292,"properties":28},{"id":1277,"createTime":28,"updateTime":28,"relativeEntities":1293,"slug":28,"properties":1294,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1296,"statistic":28},[],{"title":1295},{"VI":1282},[],{"title":1298},{"VI":1299},"Marcelo F. Vela",{"url":28,"publisher":1301,"properties":28},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1302,"slug":872,"properties":1303,"entityType":25,"verifyStatus":882,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1307,"manageAffiliations":1316,"indexDatabases":1322,"url":28,"thumbnailPath":28,"statistic":1330,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1304,"title":1305,"eissn":1306},{"VOID":877},{"EN":879},{"VOID":875},[1308,1312],{"id":885,"createTime":28,"updateTime":28,"relativeEntities":1309,"label":1310,"description":1311,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":888},{},{"id":891,"createTime":28,"updateTime":28,"relativeEntities":1313,"label":1314,"description":1315,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":894},{},[1317],{"id":898,"createTime":28,"updateTime":28,"relativeEntities":1318,"slug":28,"properties":1319,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1321,"statistic":28},[],{"title":1320},{"EN":902},[],[1323],{"id":906,"indexDatabase":1324,"url":912,"indexYears":913,"academicFieldIds":1329,"indexDatabaseRanking":917},{"id":786,"createTime":28,"updateTime":28,"relativeEntities":1325,"label":1326,"description":1327,"key":792,"publicationTags":1328,"standard":28},[],{"EN":789,"VI":789},{"EN":789,"VI":791},[794],[915,916],{"impactFactor":32,"impactFactorByYear":1331,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":920,"totalPublicationByYear":1332,"totalCitation":32,"totalCitationByYear":1333,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":1334,"hindexLast5Year":32,"hindex":32},{},{"1996":40,"1999":196,"2000":139,"2001":142,"2002":150,"2003":200,"2004":280,"2005":152,"2006":352,"2007":150,"2008":208,"2009":139,"2010":279,"2011":132,"2012":278,"2013":139,"2014":147,"2015":136,"2016":352,"2017":148,"2018":132,"2019":147,"2020":69,"2021":146,"2022":51,"2023":142,"2024":45},{},{},"2024-03-28",2024,[917],{"id":1339,"createTime":1340,"updateTime":1341,"relativeEntities":1342,"slug":1343,"properties":1344,"entityType":943,"verifyStatus":26,"verifyTime":1341,"verifyNote":1044,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1353,"fullTextUrl":28,"authors":1354,"publicationType":984,"publisherRelationship":1383,"citationCount":28,"citationInfo":28,"publishDate":1422,"publishYear":1176,"citationAnalyzeStatus":882,"lastCitationAnalyze":28,"indexDatabases":1423,"openAccess":28,"references":28,"isForceReanalyzing":1028},"01240736-4d60-4cc6-ad35-d2a69a75a2c8","2023-12-29T20:00:50.914+00:00","2025-02-13T15:15:05.302+00:00",[],"Environmental-Triggers-for-IBD",{"abstract":1345,"title":1347,"references":1349,"doi":1351},{"EN":1346},"The fundamental elucidation of how environmental influences provoke the initiation of disease as well as flares of inflammatory bowel disease (IBD) remains incomplete. The current understanding of these diseases suggests that ulcerative colitis (UC) and Crohn’s disease (CD) result from poorly defined interactions between genetic and environmental factors which culminate in the pathologic effects and clinical manifestations of these diseases. The genetic variant appears not sufficient itself to lead to the development of the clinical disease, but likely must combine with the environmental factors. The intestinal microbiome is pivotal to IBD development. A greater understanding of the contribution of these factors to dysbiosis is critical, and we aspire to restoring a healthy microbiome to treat flares and ideally prevent the development of IBD and its complications. This article aims to place the environmental influences in the context of their potential contribution to the development of the pathophysiology of IBD.",{"EN":1348},"Environmental Triggers for IBD",{"VOID":1350},"Kabi A et al. Digesting the genetics of inflammatory bowel disease: insights from studies of autophagy risk genes. Inflamm Bowel Dis. 2012;18(4):782–92.\nKaser A, Zeissig S, Blumberg RS. Inflammatory bowel disease. Annu Rev Immunol. 2010;28:573–621.\nBaumgart DC, Carding SR. Inflammatory bowel disease: cause and immunobiology. Lancet. 2007;369(9573):1627–40.\nXavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature. 2007;448(7152):427–34.\nJostins L et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 2012;491(7422):119–24.\nArimura Y, et al Characteristics of Japanese inflammatory bowel disease susceptibility loci. J Gastroenterol. 2013. doi:10.1007\u002Fs00535-013-0866-2.\nMahurkar S et al. Common variants in NOD2 and IL23R are not associated with inflammatory bowel disease in Indians. J Gastroenterol Hepatol. 2011;26(4):694–9.\nStrachan DP. Hay fever, hygiene, and household size. BMJ. 1989;299(6710):1259–60.\nForbes A, Kalantzis T. Crohn’s disease: the cold chain hypothesis. Int J Color Dis. 2006;21(5):399–401.\nFunkhouser LJ, Bordenstein SR. Mom knows best: the universality of maternal microbial transmission. PLoS Biol. 2013;11(8):e1001631.\nDominguez-Bello MG et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A. 2010;107(26):11971–5.\nBager P et al. Cesarean section and offspring’s risk of inflammatory bowel disease: a national cohort study. Inflamm Bowel Dis. 2012;18(5):857–62.\nSonntag B et al. Preterm birth but not mode of delivery is associated with an increased risk of developing inflammatory bowel disease later in life. Inflamm Bowel Dis. 2007;13(11):1385–90.\nCabrera-Rubio R et al. The human milk microbiome changes over lactation and is shaped by maternal weight and mode of delivery. Am J Clin Nutr. 2012;96(3):544–51.\nKhalili H et al. Early life factors and risk of inflammatory bowel disease in adulthood. Inflamm Bowel Dis. 2013;19(3):542–7.\nSpooren CE et al. Review article: the association of diet with onset and relapse in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38(10):1172–87.\nCastiglione F et al. Risk factors for inflammatory bowel diseases according to the “hygiene hypothesis”: a case-control, multi-centre, prospective study in Southern Italy. J Crohn’s Colitis. 2012;6(3):324–9.\nRoberts CL et al. Translocation of Crohn’s disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers. Gut. 2010;59(10):1331–9.\nMaslowski KM, Mackay CR. Diet, gut microbiota and immune responses. Nat Immunol. 2011;12(1):5–9.\nJakobsen C et al. Environmental factors and risk of developing paediatric inflammatory bowel disease—a population based study 2007–2009. J Crohn’s Colitis. 2013;7(1):79–88.\nAnanthakrishnan AN et al. A prospective study of long-term intake of dietary fiber and risk of Crohn’s disease and ulcerative colitis. Gastroenterology. 2013;145(5):970–7.\nTsiountsioura M, et al Detailed assessment of nutritional status and eating patterns in children with gastrointestinal diseases attending an outpatients clinic and contemporary healthy controls. Eur J Clin Nutr. 2014;68(6):700–6.\nBurisch J, et al Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe—an ECCO-EpiCom study. J Crohns Colitis. 2014;8(7):607–16.\nPalmblad J, Gyllenhammar H. Effect of dietary lipids on immunity and inflammation. Review article. APMIS. 1988;96(7):571–83.\nCostea I et al. Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn’s disease. Gastroenterology. 2014;146(4):929–31.\nLaing B, Han DY, Ferguson LR. Candidate genes involved in beneficial or adverse responses to commonly eaten brassica vegetables in a New Zealand Crohn’s disease cohort. Nutrient. 2013;5(12):5046–64.\nVind I et al. Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County, 2003–2005: a population-based study from the Danish Crohn colitis database. Am J Gastroenterol. 2006;101(6):1274–82.\nBenchimol EI et al. Increasing incidence of paediatric inflammatory bowel disease in Ontario, Canada: evidence from health administrative data. Gut. 2009;58(11):1490–7.\nKhalili H et al. Geographical variation and incidence of inflammatory bowel disease among US women. Gut. 2012;61(12):1686–92.\nWang TT et al. Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2\u002FCARD15-defensin beta2 innate immune pathway defective in Crohn disease. J Biol Chem. 2010;285(4):2227–31.\nOoi JH et al. Vitamin D regulates the gut microbiome and protects mice from dextran sodium sulfate-induced colitis. J Nutr. 2013;143(10):1679–86.\nBaumgart M et al. Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn’s disease involving the ileum. ISME J. 2007;1(5):403–18.\nBarnich N et al. CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. J Clin Invest. 2007;117(6):1566–74.\nMartinez-Medina M et al. Western diet induces dysbiosis with increased E coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation. Gut. 2014;63(1):116–24.\nLeigh RJ, Turnberg LA. BCG vaccination and Crohn’s disease. Dig Dis Sci. 1980;25(12):972.\nGilat T et al. Childhood factors in ulcerative colitis and Crohn’s disease. An international cooperative study. Scand J Gastroenterol. 1987;22(8):1009–24.\nBaron S et al. Environmental risk factors in paediatric inflammatory bowel diseases: a population based case control study. Gut. 2005;54(3):357–63.\nHansen TS et al. Environmental factors in inflammatory bowel disease: a case-control study based on a Danish inception cohort. J Crohn’s Colitis. 2011;5(6):577–84.\nVirta L et al. Association of repeated exposure to antibiotics with the development of pediatric Crohn’s disease—a nationwide, register-based Finnish case–control study. Am J Epidemiol. 2012;175(8):775–84.\nMarchant A et al. Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Guerin vaccination. J Immunol. 1999;163(4):2249–55.\nEnnis FA et al. Primary induction of human CD8+ cytotoxic T lymphocytes and interferon-gamma-producing T cells after smallpox vaccination. J Infect Dis. 2002;185(11):1657–9.\nVillumsen M et al. Risk of inflammatory bowel disease following Bacille Calmette-Guerin and smallpox vaccination: a population-based Danish case-cohort study. Inflamm Bowel Dis. 2013;19(8):1717–24.\nNg SC et al. Role of genetic and environmental factors in British twins with inflammatory bowel disease. Inflamm Bowel Dis. 2012;18(4):725–36.\nVan Kruiningen HJ, Freda BJ. A clustering of Crohn’s disease in Mankato, Minnesota. Inflamm Bowel Dis. 2001;7(1):27–33.\nPierce ES, Borowitz SM, Naser SA. The Broad Street pump revisited: dairy farms and an ongoing outbreak of inflammatory bowel disease in Forest, Virginia. Gut Pathog. 2011;3(1):20.\nPierce ES. Free-ranging Rocky Mountain bighorn sheep and an outbreak of inflammatory bowel disease along the Clark Fork River in Plains, Montana. Virulence. 2012;3(6):546–50.\nMasclee GM et al. Is Clostridium difficile associated with relapse of inflammatory bowel disease? Results from a retrospective and prospective cohort study in the Netherlands. Inflamm Bowel Dis. 2013;19(10):2125–31.\nAnanthakrishnan AN et al. Aspirin, nonsteroidal anti-inflammatory drug use, and risk for Crohn disease and ulcerative colitis: a cohort study. Ann Intern Med. 2012;156(5):350–9.\nMusumba C, Pritchard DM, Pirmohamed M. Review article: cellular and molecular mechanisms of NSAID-induced peptic ulcers. Aliment Pharmacol Ther. 2009;30(6):517–31.\nJenkins AP et al. Do non-steroidal anti-inflammatory drugs increase colonic permeability? Gut. 1991;32(1):66–9.\nEtminan M et al. Isotretinoin and risk for inflammatory bowel disease: a nested case-control study and meta-analysis of published and unpublished data. JAMA Dermatol. 2013;149(2):216–20.\nLooijer-van Langen M et al. Estrogen receptor-beta signaling modulates epithelial barrier function. Am J Physiol Gastrointest Liver Physiol. 2011;300(4):G621–6.\nKhalili H et al. Hormone therapy increases risk of ulcerative colitis but not Crohn’s disease. Gastroenterology. 2012;143(5):1199–206.\nKhalili H et al. Oral contraceptives, reproductive factors and risk of inflammatory bowel disease. Gut. 2013;62(8):1153–9.\nHiguchi LM et al. A prospective study of cigarette smoking and the risk of inflammatory bowel disease in women. Am J Gastroenterol. 2012;107(9):1399–406.\nBiedermann L et al. Smoking cessation induces profound changes in the composition of the intestinal microbiota in humans. PLoS One. 2013;8(3):e59260.\nVerschuere S et al. Cigarette smoke and the terminal ileum: increased autophagy in murine follicle-associated epithelium and Peyer’s patches. Histochem Cell Biol. 2012;137(3):293–301.\nHe C et al. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature. 2012;481(7382):511–5.\nKhalili H et al. Physical activity and risk of inflammatory bowel disease: prospective study from the Nurses’ Health Study cohorts. BMJ. 2013;347:f6633.\nLange T, Dimitrov S, Born J. Effects of sleep and circadian rhythm on the human immune system. Ann N Y Acad Sci. 2010;1193:48–59.\nUthgenannt D et al. Effects of sleep on the production of cytokines in humans. Psychosom Med. 1995;57(2):97–104.\nSwanson GR, Burgess HJ, Keshavarzian A. Sleep disturbances and inflammatory bowel disease: a potential trigger for disease flare? Expert Rev Clin Immunol. 2011;7(1):29–36.\nRanjbaran Z et al. The relevance of sleep abnormalities to chronic inflammatory conditions. Inflamm Res. 2007;56(2):51–7.\nOpp MR. Cytokines and sleep. Sleep Med Rev. 2005;9(5):355–64.\nAnanthakrishnan AN et al. Sleep disturbance and risk of active disease in patients with Crohn’s disease and ulcerative colitis. Clin Gastroenterol Hepatol. 2013;11(8):965–71.\nAli T et al. Assessment of the relationship between quality of sleep and disease activity in inflammatory bowel disease patients. Inflamm Bowel Dis. 2013;19(11):2440–3.\nMawdsley JE, Rampton DS. The role of psychological stress in inflammatory bowel disease. Neuroimmunomodulation. 2006;13(5–6):327–36.\nRampton DS. The influence of stress on the development and severity of immune-mediated diseases. J Rheumatol Suppl. 2011;88:43–7.\nAnanthakrishnan AN et al. Association between depressive symptoms and incidence of Crohn’s disease and ulcerative colitis: results from the Nurses’ Health Study. Clin Gastroenterol Hepatol. 2013;11(1):57–62.\nLanghorst J et al. Short-term stress, but not mucosal healing nor depression was predictive for the risk of relapse in patients with ulcerative colitis: a prospective 12-month follow-up study. Inflamm Bowel Dis. 2013;19(11):2380–6.\nVanuytsel T, et al Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism. Gut. 2014;63(8):1293–9.\nMartin Sanchez F, et al, Exposome informatics: considerations for the design of future biomedical research information systems. J Am Med Inform Assoc. 2014;21(3):386–90.\nTringe SG, Rubin EM. Metagenomics: DNA sequencing of environmental samples. Nat Rev Genet. 2005;6(11):805–14.\nGerber GK, Onderdonk AB, Bry L. Inferring dynamic signatures of microbes in complex host ecosystems. PLoS Comput Biol. 2012;8(8):e1002624.\nNes AA, et al Web-based, self-management enhancing interventions with e-diaries and personalized feedback for persons with chronic illness: a tale of three studies. Patient Educ Couns. 2013;93(3):451–8.",{"VOID":1352},"10.1007\u002Fs11894-014-0396-y","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs11894-014-0396-y",[1355,1370],{"id":1356,"sortIndex":32,"researcher":28,"roles":1357,"affiliations":1358,"properties":1367,"displayName":1369,"givenName":28,"familyName":28},"2afcbaa4-1405-4339-8511-d868d8d4ef7b",[950],[1359],{"id":1360,"sortIndex":32,"affiliation":1361,"properties":28},"8c5f974c-7cf5-40c0-866e-fe5d44073d44",{"id":1360,"createTime":28,"updateTime":28,"relativeEntities":1362,"slug":28,"properties":1363,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1366,"statistic":28},[],{"title":1364},{"VI":1365},"BWH Crohn’s and Colitis Center, Brigham and Women’s Hospital, Boston, USA",[],{"title":1368},{"VI":1369},"Aoibhlinn O’Toole",{"id":1371,"sortIndex":40,"researcher":28,"roles":1372,"affiliations":1373,"properties":1380,"displayName":1382,"givenName":28,"familyName":28},"841765ba-c22b-4abd-b39e-43a692ed9653",[950],[1374],{"id":1360,"sortIndex":32,"affiliation":1375,"properties":28},{"id":1360,"createTime":28,"updateTime":28,"relativeEntities":1376,"slug":28,"properties":1377,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1379,"statistic":28},[],{"title":1378},{"VI":1365},[],{"title":1381},{"VI":1382},"Joshua Korzenik",{"url":1353,"publisher":1384,"properties":1418},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1385,"slug":872,"properties":1386,"entityType":25,"verifyStatus":882,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1390,"manageAffiliations":1399,"indexDatabases":1405,"url":28,"thumbnailPath":28,"statistic":1413,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1387,"title":1388,"eissn":1389},{"VOID":877},{"EN":879},{"VOID":875},[1391,1395],{"id":885,"createTime":28,"updateTime":28,"relativeEntities":1392,"label":1393,"description":1394,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":888},{},{"id":891,"createTime":28,"updateTime":28,"relativeEntities":1396,"label":1397,"description":1398,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":894},{},[1400],{"id":898,"createTime":28,"updateTime":28,"relativeEntities":1401,"slug":28,"properties":1402,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1404,"statistic":28},[],{"title":1403},{"EN":902},[],[1406],{"id":906,"indexDatabase":1407,"url":912,"indexYears":913,"academicFieldIds":1412,"indexDatabaseRanking":917},{"id":786,"createTime":28,"updateTime":28,"relativeEntities":1408,"label":1409,"description":1410,"key":792,"publicationTags":1411,"standard":28},[],{"EN":789,"VI":789},{"EN":789,"VI":791},[794],[915,916],{"impactFactor":32,"impactFactorByYear":1414,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":920,"totalPublicationByYear":1415,"totalCitation":32,"totalCitationByYear":1416,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":1417,"hindexLast5Year":32,"hindex":32},{},{"1996":40,"1999":196,"2000":139,"2001":142,"2002":150,"2003":200,"2004":280,"2005":152,"2006":352,"2007":150,"2008":208,"2009":139,"2010":279,"2011":132,"2012":278,"2013":139,"2014":147,"2015":136,"2016":352,"2017":148,"2018":132,"2019":147,"2020":69,"2021":146,"2022":51,"2023":142,"2024":45},{},{},{"pages":1419,"volume":1421},{"VOID":1420},"1-6",{"VOID":1174},"2014-07-22",[917],{"id":1425,"createTime":1426,"updateTime":1426,"relativeEntities":1427,"slug":28,"properties":1428,"entityType":943,"verifyStatus":882,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1437,"fullTextUrl":28,"authors":1438,"publicationType":984,"publisherRelationship":1454,"citationCount":28,"citationInfo":28,"publishDate":1494,"publishYear":1495,"citationAnalyzeStatus":882,"lastCitationAnalyze":28,"indexDatabases":1496,"openAccess":28,"references":28,"isForceReanalyzing":1028},"01945971-31c1-4a38-ba97-284024b22258","2024-01-11T07:31:55.505+00:00",[],{"abstract":1429,"title":1431,"references":1433,"doi":1435},{"EN":1430},"The costs to society and accuracy of screening for esophageal cancer and other esophageal diseases with standard endoscopy are formidable. As a result, the applicability of endoscopy as a general screening tool has been challenged. To maintain accuracy but reduce the price of endoscopy on society, multiple adjunct or replacement technologies are being developed that are less expensive and more easily applied. These devices include image-enhancing techniques that more reliably identify dysplasia and cancer reducing the need for extensive biopsy sampling during standard endoscopy. They also include ambulatory forms for procuring esophageal imaging including smaller endoscopes and capsule endoscopy. Finally, some of the newer methods either obtain samples of esophageal tissue through bedside maneuvers not requiring endoscopy or retrieve information about mucosal inflammation and function without the need to procure esophageal tissue. There is an exciting future for esophageal diagnosis with tools that will save cost and\u002For provide greater accuracy and safety for some of the most common esophageal disorders.",{"EN":1432},"Recent Advances in Non-invasive Esophageal Tissue Sampling",{"VOID":1434},"Locke 3rd GR, Talley NJ, Fett SL, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology. 1997;112:1448–56.\nEl-Serag HB, Petersen NJ, Carter J, et al. Gastroesophageal reflux among different racial groups in the United States. Gastroenterology. 2004;126:1692–9.\nDellon ES, Jensen ET, Martin CF, et al. Prevalence of eosinophilic esophagitis in the United States. Clin Gastroenterol Hepatol. 2014;12:589-96 e1.\nPeery AF, Crockett SD, Barritt AS, et al. Burden of Gastrointestinal, Liver, and Pancreatic Diseases in the United States. Gastroenterology. 2015;149:1731-1741 e3.\nJayasekera C, Taylor AC, Desmond PV, et al. Added value of narrow band imaging and confocal laser endomicroscopy in detecting Barrett’s esophagus neoplasia. Endoscopy. 2012;44:1089–95.\nSingh R, Jayanna M, Wong J, et al. Narrow-band imaging and white-light endoscopy with optical magnification in the diagnosis of dysplasia in Barrett’s esophagus: results of the Asia-Pacific Barrett’s Consortium. Endosc Int Open. 2015;3:E14–8.\nSong J, Zhang J, Wang J, et al. Meta-analysis of the effects of endoscopy with narrow band imaging in detecting dysplasia in Barrett’s esophagus. Dis Esophagus. 2015;28:560–6.\n•• Sharma P, Bergman JJ, Goda K, et al. Development and Validation of a Classification System to Identify High-Grade Dysplasia and Esophageal Adenocarcinoma in Barrett’s Esophagus Using Narrow-Band Imaging. Gastroenterology. 2016;150:591–8. This study performed by experts in Barrett’s esophagus and narrow band imaging provides a compelling simple, internally validated system to identify dysplasia and EAC in patients with BE based on NBI results.\nThosani N, Abu Dayyeh BK, Sharma P, et al. ASGE Technology Committee systematic review and meta-analysis assessing the ASGE Preservation and Incorporation of Valuable Endoscopic Innovations thresholds for adopting real-time imaging-assisted endoscopic targeted biopsy during endoscopic surveillance of Barrett’s esophagus. Gastrointest Endosc. 2016;83:684-98 e7.\nSharma P, Brill J, Canto M, et al. White Paper AGA: advanced imaging in Barrett’s esophagus. Clin Gastroenterol Hepatol. 2015;13:2209–18.\ndi Pietro M, Bird-Lieberman EL, Liu X, et al. Autofluorescence-directed confocal endomicroscopy in combination with a three-biomarker panel can inform management decisions in Barrett’s esophagus. Am J Gastroenterol. 2015;110:1549–58.\nGong EJ, Kim DH, Ahn JY, et al. Routine endoscopic screening for synchronous esophageal neoplasm in patients with head and neck squamous cell carcinoma: a prospective study. Dis Esophagus. 2016. doi:10.1111\u002Fdote.12404.\nCarvalho R, Areia M, Brito D, et al. Diagnostic accuracy of lugol chromoendoscopy in the oesophagus in patients with head and neck cancer. Rev Esp Enferm Dig. 2013;105:79–83.\nHori K, Okada H, Kawahara Y, et al. Lugol-voiding lesions are an important risk factor for a second primary squamous cell carcinoma in patients with esosphageal cancer or head and neck cancer. Am J Gastroenterol. 2011;106:858–66.\nChung CS, Lo WC, Lee YC, et al. Image-enhanced endoscopy for detection of second primary neoplasm in patients with esophageal and head and neck cancer: a systematic review and meta-analysis. Head Neck. 2016;38 Suppl 1:E2343–9.\nLecleire S, Antonietti M, Iwanicki-Caron I, et al. Lugol chromo-endoscopy versus narrow band imaging for endoscopic screening of esophageal squamous-cell carcinoma in patients with a history of cured esophageal cancer: a feasibility study. Dis Esophagus. 2011;24:418–22.\nSami SS, Dunagan KT, Johnson ML, et al. A randomized comparative effectiveness trial of novel endoscopic techniques and approaches for Barrett’s esophagus screening in the community. Am J Gastroenterol. 2015;110:148–58.\nPeery AF, Hoppo T, Garman KS, et al. Feasibility, safety, acceptability, and yield of office-based, screening transnasal esophagoscopy (with video). Gastrointest Endosc. 2012;75:945-953 e2.\nCrews NR, Johnson ML, Schleck CD, et al. Prevalence and predictors of gastroesophageal reflux complications in community subjects. Dig Dis Sci. 2016;61(11):3221–8.\nAlashkar B, Faulx AL, Hepner A, et al. Development of a program to train physician extenders to perform transnasal esophagoscopy and screen for Barrett’s esophagus. Clin Gastroenterol Hepatol. 2014;12:785–92.\nArantes V, Albuquerque W, Salles JM, et al. Effectiveness of unsedated transnasal endoscopy with white-light, flexible spectral imaging color enhancement, and lugol staining for esophageal cancer screening in high-risk patients. J Clin Gastroenterol. 2013;47:314–21.\nWang CH, Lee YC, Wang CP, et al. Use of transnasal endoscopy for screening of esophageal squamous cell carcinoma in high-risk patients: yield rate, completion rate, and safety. Dig Endosc. 2014;26:24–31.\ndi Pietro M, Chan D, Fitzgerald RC, et al. Screening for Barrett’s esophagus. Gastroenterology. 2015;148:912–23.\nDomingos TA, Moura EG, Mendes DC, et al. Comparative evaluation of esophageal Barrett’s epithelium through esophageal capsule endoscopy and methylene blue chromoendoscopy. Rev Gastroenterol Mex. 2013;78:57–63.\nBhardwaj A, Hollenbeak CS, Pooran N, et al. A meta-analysis of the diagnostic accuracy of esophageal capsule endoscopy for Barrett’s esophagus in patients with gastroesophageal reflux disease. Am J Gastroenterol. 2009;104:1533–9.\nChak A, Alashkar BM, Isenberg GA, et al. Comparative acceptability of transnasal esophagoscopy and esophageal capsule esophagoscopy: a randomized, controlled trial in veterans. Gastrointest Endosc. 2014;80:774–82.\nGupta M, Beebe TJ, Dunagan KT, et al. Screening for Barrett’s esophagus: results from a population-based survey. Dig Dis Sci. 2014;59:1831–50.\nWaterman M, Gralnek IM. Capsule endoscopy of the esophagus. J Clin Gastroenterol. 2009;43:605–12.\nGora MJ, Sauk JS, Carruth RW, et al. Imaging the upper gastrointestinal tract in unsedated patients using tethered capsule endomicroscopy. Gastroenterology. 2013;145:723–5.\nChavalitdhamrong D, Chen GC, Roth BE, et al. Esophageal capsule endoscopy for evaluation of patients with chronic gastroesophageal reflux symptoms: findings and its image quality. Dis Esophagus. 2011;24:295–8.\n• Ross-Innes CS, Debiram-Beecham I, O’Donovan M, et al. Evaluation of a minimally invasive cell sampling device coupled with assessment of trefoil factor 3 expression for diagnosing Barrett’s esophagus: a multi-center case-control study. PLoS Med. 2015;12:e1001780. This may well be the future in screening for Barrett’s esophagus and adenocarcinoma. It is a simple, safe, accurate, bedside test which can be performed by physicians and physician extenders and avoid the need for screening endoscopy.\nBenaglia T, Sharples LD, Fitzgerald RC, et al. Health benefits and cost effectiveness of endoscopic and nonendoscopic cytosponge screening for Barrett’s esophagus. Gastroenterol. 2013;144:62-73 e6.\nKatzka DA, Geno DM, Ravi A, et al. Accuracy, safety, and tolerability of tissue collection by Cytosponge vs endoscopy for evaluation of eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2015;13:77-83 e2.\nLiu SF, Shen Q, Dawsey SM, et al. Esophageal balloon cytology and subsequent risk of esophageal and gastric-cardia cancer in a high-risk Chinese population. Int J Cancer. 1994;57:775–80.\nWang LD, Yang HH, Fan ZM, et al. Cytological screening and 15 years’ follow-up (1986-2001) for early esophageal squamous cell carcinoma and precancerous lesions in a high-risk population in Anyang County, Henan Province, Northern China. Cancer Detect Prev. 2005;29:317–22.\nPan QJ, Roth MJ, Guo HQ, et al. Cytologic detection of esophageal squamous cell carcinoma and its precursor lesions using balloon samplers and liquid-based cytology in asymptomatic adults in Llinxian, China. Acta Cytol. 2008;52:14–23.\nFalk GW, Chittajallu R, Goldblum JR, et al. Surveillance of patients with Barrett’s esophagus for dysplasia and cancer with balloon cytology. Gastroenterology. 1997;112:1787–97.\n•• Ates F, Yuksel ES, Higginbotham T, et al. Mucosal impedance discriminates GERD from non-GERD conditions. Gastroenterology. 2015;148:334–43. This is a fascinating study applying the use of measuring esophageal mucosa impedance to disease. As decreased impedance reflects increased tissue permeability and compromise of the epithelial barrier, several tools to measure esophageal impedance may become an important tool in assessing esophageal inflammatory diseases.\nSaritas Yuksel E, Higginbotham T, Slaughter JC, et al. Use of direct, endoscopic-guided measurements of mucosal impedance in diagnosis of gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2012;10:1110–6.\nKatzka DA, Ravi K, Geno DM, et al. Endoscopic Mucosal Impedance Measurements Correlate With Eosinophilia and Dilation of Intercellular Spaces in Patients With Eosinophilic Esophagitis. Clin Gastroenterol Hepatol. 2015;13:1242-1248 e1.\nvan Rhijn BD, Kessing BF, Smout AJ, et al. Oesophageal baseline impedance values are decreased in patients with eosinophilic oesophagitis. United Eur Gastroenterol J. 2013;1:242–8.",{"VOID":1436},"10.1007\u002Fs11894-017-0550-4","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs11894-017-0550-4",[1439],{"id":1440,"sortIndex":32,"researcher":28,"roles":1441,"affiliations":1442,"properties":1451,"displayName":1453,"givenName":28,"familyName":28},"c93741a3-fbdc-40a1-ac19-e5b41e9cab51",[950],[1443],{"id":1444,"sortIndex":32,"affiliation":1445,"properties":28},"3ba4d788-7368-4166-9257-4706beb5abb8",{"id":1444,"createTime":28,"updateTime":28,"relativeEntities":1446,"slug":28,"properties":1447,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1450,"statistic":28},[],{"title":1448},{"VI":1449},"Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, USA",[],{"title":1452},{"VI":1453},"David A. Katzka",{"url":1437,"publisher":1455,"properties":1489},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1456,"slug":872,"properties":1457,"entityType":25,"verifyStatus":882,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1461,"manageAffiliations":1470,"indexDatabases":1476,"url":28,"thumbnailPath":28,"statistic":1484,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1458,"title":1459,"eissn":1460},{"VOID":877},{"EN":879},{"VOID":875},[1462,1466],{"id":885,"createTime":28,"updateTime":28,"relativeEntities":1463,"label":1464,"description":1465,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":888},{},{"id":891,"createTime":28,"updateTime":28,"relativeEntities":1467,"label":1468,"description":1469,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":894},{},[1471],{"id":898,"createTime":28,"updateTime":28,"relativeEntities":1472,"slug":28,"properties":1473,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1475,"statistic":28},[],{"title":1474},{"EN":902},[],[1477],{"id":906,"indexDatabase":1478,"url":912,"indexYears":913,"academicFieldIds":1483,"indexDatabaseRanking":917},{"id":786,"createTime":28,"updateTime":28,"relativeEntities":1479,"label":1480,"description":1481,"key":792,"publicationTags":1482,"standard":28},[],{"EN":789,"VI":789},{"EN":789,"VI":791},[794],[915,916],{"impactFactor":32,"impactFactorByYear":1485,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":920,"totalPublicationByYear":1486,"totalCitation":32,"totalCitationByYear":1487,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":1488,"hindexLast5Year":32,"hindex":32},{},{"1996":40,"1999":196,"2000":139,"2001":142,"2002":150,"2003":200,"2004":280,"2005":152,"2006":352,"2007":150,"2008":208,"2009":139,"2010":279,"2011":132,"2012":278,"2013":139,"2014":147,"2015":136,"2016":352,"2017":148,"2018":132,"2019":147,"2020":69,"2021":146,"2022":51,"2023":142,"2024":45},{},{},{"pages":1490,"volume":1492},{"VOID":1491},"1-7",{"VOID":1493},"19","2017-03-09",2017,[917],{"id":1498,"createTime":1499,"updateTime":1500,"relativeEntities":1501,"slug":1502,"properties":1503,"entityType":943,"verifyStatus":26,"verifyTime":1500,"verifyNote":1044,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1512,"fullTextUrl":28,"authors":1513,"publicationType":984,"publisherRelationship":1568,"citationCount":28,"citationInfo":28,"publishDate":1608,"publishYear":1609,"citationAnalyzeStatus":882,"lastCitationAnalyze":28,"indexDatabases":1610,"openAccess":28,"references":28,"isForceReanalyzing":1028},"0198c075-6b58-4bd0-8bcf-cc780ab73486","2024-01-20T02:47:04.619+00:00","2024-12-19T20:07:51.522+00:00",[],"Management-and-Complications-of-Short-Bowel-Syndrome-an-Updated-Review",{"abstract":1504,"title":1506,"references":1508,"doi":1510},{"EN":1505},"Short bowel syndrome (SBS) is defined as loss of bowel mass from surgical resection, congenital defects, or disease. Intestinal failure (IF) includes the subset of SBS unable to meet nutrition needs with enteral supplements and requires parenteral nutrition (PN). The parenteral treatment of SBS is now a half-century old. Recent pharmacologic treatment (GLP-2 analogues) has begun to make a significant impact in the care and ultimate management of these patients such that the possibility of reducing PN requirements in formerly PN-dependent patients is a now a real possibility. Finally, newer understanding and possible treatment for some of the complications related to IF have more recently evolved and will be an emphasis of this report. This review will focus on developments over the last 10 years with the goal of updating the reader to new advances in our understanding of the care and feeding of the SBS patient.",{"EN":1507},"Management and Complications of Short Bowel Syndrome: an Updated Review",{"VOID":1509},"O’Keefe SJ, Buchman AL, Fishbein TM, Jeejeebhoy KN, Jeppesen PB, Shaffer J. Short bowel syndrome and intestinal failure: consensus definitions and overview. Clin Gastroenterol Hepatol. 2006;4(1):6–10. doi:10.1016\u002Fj.cgh.2005.10.002.\nDudrick SJ, Wilmore DW, Vars HM, Rhoads JE. Long-term total parenteral nutrition with growth, development, and positive nitrogen balance. Surgery. 1968;64(1):134–42.\nBuchman AL, Scolapio J, Fryer J. AGA technical review on short bowel syndrome and intestinal transplantation. Gastroenterology. 2003;124(4):1111–34. doi:10.1053\u002Fgast.2003.50139a.\nMullady DK, O’Keefe SJ. Treatment of intestinal failure: home parenteral nutrition. Nat Clin Pract Gastroenterol Hepatol. 2006;3(9):492–504. doi:10.1038\u002Fncpgasthep0580.\nNightingale J, Woodward JM, Gastroenterology SBaNCotBSo. Guidelines for management of patients with a short bowel. Gut. 2006;55 Suppl 4:iv1–12.\nSinha R, Trivedi D, Murphy PD, Fallis S. Small-intestinal length measurement on MR enterography: comparison with in vivo surgical measurement. AJR Am J Roentgenol. 2014;203(3):W274–9. doi:10.2214\u002FAJR.13.11944.\nCarbonnel F, Cosnes J, Chevret S, Beaugerie L, Ngô Y, Malafosse M, et al. The role of anatomic factors in nutritional autonomy after extensive small bowel resection. JPEN J Parenter Enteral Nutr. 1996;20(4):275–80.\nKurkchubasche AG, Rowe MI, Smith SD. Adaptation in short-bowel syndrome: reassessing old limits. J Pediatr Surg. 1993;28(8):1069–71.\nCrenn P, Messing B, Cynober L. Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction. Clin Nutr. 2008;27(3):328–39. doi:10.1016\u002Fj.clnu.2008.02.005.\nSigalet DL, Martin G, Meddings J, Hartman B, Holst JJ. GLP-2 levels in infants with intestinal dysfunction. Pediatr Res. 2004;56(3):371–6. doi:10.1203\u002F01.PDR.0000134250.80492.EC.\nZiv YH, Burrow T, Kocoshis S, Pentiuk S. Encephalopathy in a patient with short bowel syndrome: case report and discussion of the pathophysiology. JPEN J Parenter Enteral Nutr. 2014;38(4):518–20. doi:10.1177\u002F0148607113496819.\nWeale AR, Edwards AG, Bailey M, Lear PA. Intestinal adaptation after massive intestinal resection. Postgrad Med J. 2005;81(953):178–84. doi:10.1136\u002Fpgmj.2004.023846.\nMiskowiak J, Andersen B. Bypass revision in unsatisfactory weight loss after jejunoileal bypass for morbid obesity. Scand J Gastroenterol. 1982;17(2):317–9.\nTappenden KA. Intestinal adaptation following resection. JPEN J Parenter Enteral Nutr. 2014;38(1 Suppl):23S–31. doi:10.1177\u002F0148607114525210.\nMessing B, Crenn P, Beau P, Boutron-Ruault MC, Rambaud JC, Matuchansky C. Long-term survival and parenteral nutrition dependence in adult patients with the short bowel syndrome. Gastroenterology. 1999;117(5):1043–50.\nHiguera I, Garcia-Peris P, Camblor M, Bretón I, Velasco C, Romero R, et al. Outcomes of a general hospital-based home parenteral nutrition (HPN) program; report of our experience from a 26-year period. Nutr Hosp. 2014;30(2):359–65. doi:10.3305\u002Fnh.2014.30.2.7592.\nJeppesen PB, Pertkiewicz M, Messing B, Iyer K, Seidner DL, O’keefe SJ, et al. Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure. Gastroenterology. 2012;143(6):1473–81.e3. doi:10.1053\u002Fj.gastro.2012.09.007. Teduglutide is the most significant medical advance in the treatment of SBS since the development of PN.\nKelly DG, Tappenden KA, Winkler MF. Short bowel syndrome: highlights of patient management, quality of life, and survival. JPEN J Parenter Enteral Nutr. 2014;38(4):427–37. doi:10.1177\u002F0148607113512678.\nVantini I, Benini L, Bonfante F, Talamini G, Sembenini C, Chiarioni G, et al. Survival rate and prognostic factors in patients with intestinal failure. Dig Liver Dis. 2004;36(1):46–55. doi:10.1016\u002Fj.dld.2003.09.015.\nLloyd DA, Vega R, Bassett P, Forbes A, Gabe SM. Survival and dependence on home parenteral nutrition: experience over a 25-year period in a UK referral centre. Aliment Pharmacol Ther. 2006;24(8):1231–40. doi:10.1111\u002Fj.1365-2036.2006.03106.x.\nCrenn P, Rakotoanbinina B, Raynaud JJ, Thuillier F, Messing B, Melchior JC. Hyperphagia contributes to the normal body composition and protein-energy balance in HIV-infected asymptomatic men. J Nutr. 2004;134(9):2301–6.\nNightingale JM. Management of patients with a short bowel. World J Gastroenterol. 2001;7(6):741–51.\nMessing B, Pigot F, Rongier M, Morin MC, Ndeïndoum U, Rambaud JC. Intestinal absorption of free oral hyperalimentation in the very short bowel syndrome. Gastroenterology. 1991;100(6):1502–8.\nQandeel HG, Alonso F, Hernandez DJ, Madhavan S, Duenes JA, Zheng Y, et al. Peptide absorption after massive proximal small bowel resection: mechanisms of ileal adaptation. J Gastrointest Surg. 2011;15(9):1537–47. doi:10.1007\u002Fs11605-011-1581-z.\nBuyse M, Berlioz F, Guilmeau S, Tsocas A, Voisin T, Péranzi G, et al. PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine. J Clin Invest. 2001;108(10):1483–94. doi:10.1172\u002FJCI13219.\nHindlet P, Bado A, Farinotti R, Buyse M. Long-term effect of leptin on H+-coupled peptide cotransporter 1 activity and expression in vivo: evidence in leptin-deficient mice. J Pharmacol Exp Ther. 2007;323(1):192–201. doi:10.1124\u002Fjpet.107.125799.\nMcIntyre PB, Fitchew M, Lennard-Jones JE. Patients with a high jejunostomy do not need a special diet. Gastroenterology. 1986;91(1):25–33.\nCosnes J, Evard D, Beaugerie L, Gendre JP, Le Quintrec Y. Improvement in protein absorption with a small-peptide-based diet in patients with high jejunostomy. Nutrition. 1992;8(6):406–11.\nNovak F, Heyland DK, Avenell A, Drover JW, Su X. Glutamine supplementation in serious illness: a systematic review of the evidence. Crit Care Med. 2002;30(9):2022–9. doi:10.1097\u002F01.CCM.0000026106.58241.95.\nByrne TA, Wilmore DW, Iyer K, Dibaise J, Clancy K, Robinson MK, et al. Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome: a prospective, randomized, placebo-controlled, double-blind clinical trial. Ann Surg. 2005;242(5):655–61.\nWales PW, Nasr A, de Silva N, Yamada J. Human growth hormone and glutamine for patients with short bowel syndrome. Cochrane Database Syst Rev. 2010;6:CD006321. doi:10.1002\u002F14651858.CD006321.pub2.\nScolapio JS. Short bowel syndrome: recent clinical outcomes with growth hormone. Gastroenterology. 2006;130(2 Suppl 1):S122–6. doi:10.1053\u002Fj.gastro.2005.12.003.\nCardell RR, Badenhausen S, Porter KR. Intestinal triglyceride absorption in the rat. An electron microscopical study. J Cell Biol. 1967;34(1):123–55.\nAlrefai WA, Gill RK. Bile acid transporters: structure, function, regulation and pathophysiological implications. Pharm Res. 2007;24(10):1803–23. doi:10.1007\u002Fs11095-007-9289-1.\nHofmann AF, Hagey LR. Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell Mol Life Sci. 2008;65(16):2461–83. doi:10.1007\u002Fs00018-008-7568-6.\nKapral C, Wewalka F, Praxmarer V, Lenz K, Hofmann AF. Conjugated bile acid replacement therapy in short bowel syndrome patients with a residual colon. Z Gastroenterol. 2004;42(7):583–9. doi:10.1055\u002Fs-2004-813059.\nFaber J, Goldstein R, Blondheim O, Stankiewicz H, Darwashi A, Bar-Maor JA, et al. Absorption of medium chain triglycerides in the stomach of the human infant. J Pediatr Gastroenterol Nutr. 1988;7(2):189–95.\nJeppesen PB, Mortensen PB. The influence of a preserved colon on the absorption of medium chain fat in patients with small bowel resection. Gut. 1998;43(4):478–83.\nGray GM. Carbohydrate digestion and absorption. Role of the small intestine. N Engl J Med. 1975;292(23):1225–30. doi:10.1056\u002FNEJM197506052922308.\nCura AJ, Carruthers A. Role of monosaccharide transport proteins in carbohydrate assimilation, distribution, metabolism, and homeostasis. Compr Physiol. 2012;2(2):863–914. doi:10.1002\u002Fcphy.c110024.\nHamilton KL, Butt AG. Glucose transport into everted sacs of the small intestine of mice. Adv Physiol Educ. 2013;37(4):415–26. doi:10.1152\u002Fadvan.00017.2013.\nDepoortere I. Taste receptors of the gut: emerging roles in health and disease. Gut. 2014;63(1):179–90. doi:10.1136\u002Fgutjnl-2013-305112.\nAtia A, Girard-Pipau F, Hébuterne X, Spies WG, Guardiola A, Ahn CW, et al. Macronutrient absorption characteristics in humans with short bowel syndrome and jejunocolonic anastomosis: starch is the most important carbohydrate substrate, although pectin supplementation may modestly enhance short chain fatty acid production and fluid absorption. JPEN J Parenter Enteral Nutr. 2011;35(2):229–40. doi:10.1177\u002F0148607110378410.\nNordgaard I, Hansen BS, Mortensen PB. Colon as a digestive organ in patients with short bowel. Lancet. 1994;343(8894):373–6.\nden Besten G, Lange K, Havinga R, van Dijk TH, Gerding A, van Eunen K, et al. Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids. Am J Physiol Gastrointest Liver Physiol. 2013;305(12):G900–10. doi:10.1152\u002Fajpgi.00265.2013.\nSchiano TD, Klang MG, Quesada E, Scott F, Tao Y, Shike M. Thiamine status in patients receiving long-term home parenteral nutrition. Am J Gastroenterol. 1996;91(12):2555–9.\nLakhani SV, Shah HN, Alexander K, Finelli FC, Kirkpatrick JR, Koch TR. Small intestinal bacterial overgrowth and thiamine deficiency after Roux-en-Y gastric bypass surgery in obese patients. Nutr Res. 2008;28(5):293–8. doi:10.1016\u002Fj.nutres.2008.03.002.\nJustino SR, Gonçalves Dias MC, Maculevicius J, Batista de Morais M, Sing TC, Halpern A, et al. Fasting breath hydrogen concentration in short bowel syndrome patients with colon incontinuity before and after antibiotic therapy. Nutrition. 2004;20(2):187–91. doi:10.1016\u002Fj.nut.2003.10.009.\nDuerksen DR, Fallows G, Bernstein CN. Vitamin B12 malabsorption in patients with limited ileal resection. Nutrition. 2006;22(11-12):1210–3. doi:10.1016\u002Fj.nut.2006.08.017.\nPedersen GA, Chakraborty S, Steinhauser AL, Traub LM, Madsen M. AMN directs endocytosis of the intrinsic factor-vitamin B(12) receptor cubam by engaging ARH or Dab2. Traffic. 2010;11(5):706–20. doi:10.1111\u002Fj.1600-0854.2010.01042.x.\nRenner AB, Dietrich-Ntoukas T, Jägle H. Recurrent episodes of night blindness in a patient with short bowel syndrome. Doc Ophthalmol. 2015;131(3):221–30. doi:10.1007\u002Fs10633-015-9516-8.\nBraga CB, Vannucchi H, Freire CM, Marchini JS, Jordão AA, da Cunha SF. Serum vitamins in adult patients with short bowel syndrome receiving intermittent parenteral nutrition. JPEN J Parenter Enteral Nutr. 2011;35(4):493–8. doi:10.1177\u002F0148607110386964.\nTouloukian RJ, Gertner JM. Vitamin D deficiency rickets as a late complication of the short gut syndrome during infancy. J Pediatr Surg. 1981;16(3):230–5.\nMargulies SL, Kurian D, Elliott MS, Han Z. Vitamin D deficiency in patients with intestinal malabsorption syndromes—think in and outside the gut. J Dig Dis. 2015;16(11):617–33. doi:10.1111\u002F1751-2980.12283.\nJeejeebhoy K. Zinc: an essential trace element for parenteral nutrition. Gastroenterology. 2009;137(5 Suppl):S7–12. doi:10.1053\u002Fj.gastro.2009.08.014.\nIshida T, Himeno K, Torigoe Y, Inoue M, Wakisaka O, Tabuki T, et al. Selenium deficiency in a patient with Crohn’s disease receiving long-term total parenteral nutrition. Intern Med. 2003;42(2):154–7.\nBlaszyk H, Wild PJ, Oliveira A, Kelly DG, Burgart LJ. Hepatic copper in patients receiving long-term total parenteral nutrition. J Clin Gastroenterol. 2005;39(4):318–20.\nVanek VW. Review of trace mineral requirements for preterm infants: what are the current recommendations for clinical practice? Nutr Clin Pract. 2015;30(5):720–1. doi:10.1177\u002F0884533615598965. The identification of potential toxicity of parenteral vitamins is of significance for adult and peditric PN population. This review addresses a potential safety problem with the use of these preparations.\nHardy G. Manganese in parenteral nutrition: who, when, and why should we supplement? Gastroenterology. 2009;137(5 Suppl):S29–35. doi:10.1053\u002Fj.gastro.2009.08.011.\nMoukarzel A. Chromium in parenteral nutrition: too little or too much? Gastroenterology. 2009;137(5 Suppl):S18–28. doi:10.1053\u002Fj.gastro.2009.08.048.\nStraus E, Yalow RS. Studies on the distribution and degradation of heptadecapeptide, big, and big big gastrin. Gastroenterology. 1974;66(5):936–43.\nBuchman AL, Fryer J, Wallin A, Ahn CW, Polensky S, Zaremba K. Clonidine reduces diarrhea and sodium loss in patients with proximal jejunostomy: a controlled study. JPEN J Parenter Enteral Nutr. 2006;30(6):487–91.\nNehra V, Camilleri M, Burton D, Oenning L, Kelly DG. An open trial of octreotide long-acting release in the management of short bowel syndrome. Am J Gastroenterol. 2001;96(5):1494–8. doi:10.1111\u002Fj.1572-0241.2001.03803.x.\nGómez-Herrera E, Farías-Llamas OA, Gutiérrez-de la Rosa JL, Hermosillo-Sandoval JM. The role of long-acting release (LAR) depot octreotide as adjuvant management of short bowel disease]. Cir Cir. 2004;72(5):379–86. doi:10.3201\u002Feid1011.040428.\nSato D, Morino K, Ohashi N, Ueda E, Ikeda K, Yamamoto H, et al. Octreotide improves early dumping syndrome potentially through incretins: a case report. Endocr J. 2013;60(7):847–53.\nHussaini SH, Pereira SP, Murphy GM, Kennedy C, Wass JA, Besser GM, et al. Composition of gall bladder stones associated with octreotide: response to oral ursodeoxycholic acid. Gut. 1995;36(1):126–32.\nSukhotnik I, Khateeb K, Krausz MM, Sabo E, Siplovich L, Coran AG, et al. Sandostatin impairs postresection intestinal adaptation in a rat model of short bowel syndrome. Dig Dis Sci. 2002;47(9):2095–102.\nHediger MA, Turk E, Pajor AM, Wright EM. Molecular genetics of the human Na+\u002Fglucose cotransporter. Klin Wochenschr. 1989;67(17):843–6.\nWright EM, Loo DD, Hirayama BA, Turk E. Surprising versatility of Na+-glucose cotransporters: SLC5. Physiology (Bethesda). 2004;19:370–6. doi:10.1152\u002Fphysiol.00026.2004.\nFreedman SB, Cho D, Boutis K, Stephens D, Schuh S. Assessing the palatability of oral rehydration solutions in school-aged children: a randomized crossover trial. Arch Pediatr Adolesc Med. 2010;164(8):696–702. doi:10.1001\u002Farchpediatrics.2010.129.\nMansmann H. Lab diagnosis of magnesium deficiency. The BartterSite 2008\nAnast CS, Winnacker JL, Forte LR, Burns TW. Impaired release of parathyroid hormone in magnesium deficiency. J Clin Endocrinol Metab. 1976;42(4):707–17. doi:10.1210\u002Fjcem-42-4-707.\nHahn M, Raithel M, Hagel A, Biermann T, Manger B. Chronic calcium pyrophosphate crystal inflammatory arthritis induced by extreme hypomagnesemia in short bowel syndrome. BMC Gastroenterol. 2012;12:129. doi:10.1186\u002F1471-230X-12-129.\nFlorentin M, Elisaf MS. Proton pump inhibitor-induced hypomagnesemia: a new challenge. World J Nephrol. 2012;1(6):151–4. doi:10.5527\u002Fwjn.v1.i6.151.\nThulesen J. Glucagon-like peptide 2 (GLP-2), an intestinotrophic mediator. Curr Protein Pept Sci. 2004;5(1):51–65.\nDrucker DJ, Yusta B. Physiology and pharmacology of the enteroendocrine hormone glucagon-like peptide-2. Annu Rev Physiol. 2014;76:561–83. doi:10.1146\u002Fannurev-physiol-021113-170317. Dr. Drucker’s cloning and characterization of GLP-2 and its cognate receptor identified the most important trophic hormone of the small intestine known to date.\nJeppesen PB, Sanguinetti EL, Buchman A, Howard L, Scolapio JS, Ziegler TR, et al. Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients. Gut. 2005;54(9):1224–31. doi:10.1136\u002Fgut.2004.061440.\nThulesen J, Hartmann B, Hare KJ, Kissow H, Ørskov C, Holst JJ, et al. Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice. Gut. 2004;53(8):1145–50. doi:10.1136\u002Fgut.2003.035212.\nRoslyn JJ, Pitt HA, Mann L, Fonkalsrud EW, DenBesten L. Parenteral nutrition-induced gallbladder disease: a reason for early cholecystectomy. Am J Surg. 1984;148(1):58–63.\nThompson JS. The role of prophylactic cholecystectomy in the short-bowel syndrome. Arch Surg. 1996;131(5):556–9. discussion 9-60.\nHutchinson R, Tyrrell PN, Kumar D, Dunn JA, Li JK, Allan RN. Pathogenesis of gall stones in Crohn’s disease: an alternative explanation. Gut. 1994;35(1):94–7.\nRedfern JS, Fortuner WJ. Octreotide-associated biliary tract dysfunction and gallstone formation: pathophysiology and management. Am J Gastroenterol. 1995;90(7):1042–52.\nBuchman AL, Moukarzel A. Metabolic bone disease associated with total parenteral nutrition. Clin Nutr. 2000;19(4):217–31. doi:10.1054\u002Fclnu.1999.0083.\nPironi L, Labate AM, Pertkiewicz M, Przedlacki J, Tjellesen L, Staun M, et al. Prevalence of bone disease in patients on home parenteral nutrition. Clin Nutr. 2002;21(4):289–96.\nBraga CB, Bizari L, Suen VM, Marchini JS, Paula FJ, Cunha SF. Bone mineral density in short bowel syndrome: correlation with BMI and serum vitamins C, E and K. Arch Endocrinol Metab. 2015;59(3):252–8. doi:10.1590\u002F2359-3997000000046.\nAment ME. Bone mineral content in patients with short bowel syndrome: the impact of parenteral nutrition. J Pediatr. 1998;132(3 Pt 1):386–8.\nTangpricha V, Luo M, Fernández-Estívariz C, Gu LH, Bazargan N, Klapproth JM, et al. Growth hormone favorably affects bone turnover and bone mineral density in patients with short bowel syndrome undergoing intestinal rehabilitation. JPEN J Parenter Enteral Nutr. 2006;30(6):480–6.\nHaderslev KV, Jeppesen PB, Hartmann B, Thulesen J, Sorensen HA, Graff J, et al. Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon. Scand J Gastroenterol. 2002;37(4):392–8.\nEmmett M, Guirl MJ, Santa Ana CA, Porter JL, Neimark S, Hofmann AF, et al. Conjugated bile acid replacement therapy reduces urinary oxalate excretion in short bowel syndrome. Am J Kidney Dis. 2003;41(1):230–7. doi:10.1053\u002Fajkd.2003.50012.\nFinkielstein VA, Goldfarb DS. Strategies for preventing calcium oxalate stones. CMAJ. 2006;174(10):1407–9. doi:10.1503\u002Fcmaj.051517.\nLuman W, Shaffer JL. Prevalence, outcome and associated factors of deranged liver function tests in patients on home parenteral nutrition. Clin Nutr. 2002;21(4):337–43.\nKelly DA. Intestinal failure-associated liver disease: what do we know today? Gastroenterology. 2006;130(2 Suppl 1):S70–7. doi:10.1053\u002Fj.gastro.2005.10.066.\nFitzgibbons SC, Jones BA, Hull MA, Zurakowski D, Duro D, Duggan C, et al. Relationship between biopsy-proven parenteralnutrition-associated liver fibrosis and biochemical cholestasis in children with short bowel syndrome. J Pediatr Surg. 2010;45(1):95–9. doi:10.1016\u002Fj.jpedsurg.2009.10.020. discussion 9.\nFong DG, Nehra V, Lindor KD, Buchman AL. Metabolic and nutritional considerations in nonalcoholic fatty liver. Hepatology. 2000;32(1):3–10. doi:10.1053\u002Fjhep.2000.8978.\nRollins MD, Scaife ER, Jackson WD, Meyers RL, Mulroy CW, Book LS. Elimination of soybean lipid emulsion in parenteral nutrition and supplementation with enteral fish oil improve cholestasis in infants with short bowel syndrome. Nutr Clin Pract. 2010;25(2):199–204. doi:10.1177\u002F0884533610361477.\nXu Z, Li Y, Wang J, Wu B, Li J. Effect of omega-3 polyunsaturated fatty acids to reverse biopsy-proven parenteral nutrition-associated liver disease in adults. Clin Nutr. 2012;31(2):217–23. doi:10.1016\u002Fj.clnu.2011.10.001.\nMercer DF, Hobson BD, Fischer RT, Talmon GA, Perry DA, Gerhardt BK, et al. Hepatic fibrosis persists and progresses despite biochemical improvement in children treated with intravenous fish oil emulsion. J Pediatr Gastroenterol Nutr. 2013;56(4):364–9. doi:10.1097\u002FMPG.0b013e31827e208c.\nMatsumoto CS, Kaufman SS, Island ER, Kallakury B, Yazigi NA, Khan KM, et al. Hepatic explant pathology of pediatric intestinal transplant recipients previously treated with omega-3 fatty acid lipid emulsion. J Pediatr. 2014;165(1):59–64. doi:10.1016\u002Fj.jpeds.2014.03.034.\nKlek S, Chambrier C, Singer P, Rubin M, Bowling T, Staun M, et al. Four-week parenteral nutrition using a third generation lipid emulsion (SMOFlipid)—a double-blind, randomised, multicentre study in adults. Clin Nutr. 2013;32(2):224–31. doi:10.1016\u002Fj.clnu.2012.06.011.\nBuchman AL, Ament ME, Sohel M, Dubin M, Jenden DJ, Roch M, et al. Choline deficiency causes reversible hepatic abnormalities in patients receiving parenteral nutrition: proof of a human choline requirement: a placebo-controlled trial. JPEN J Parenter Enteral Nutr. 2001;25(5):260–8.\nSentongo TA, Kumar P, Karza K, Keys L, Iyer K, Buchman AL. Whole-blood-free choline and choline metabolites in infants who require chronic parenteral nutrition therapy. J Pediatr Gastroenterol Nutr. 2010;50(2):194–9. doi:10.1097\u002FMPG.0b013e3181a93735.\nDunlop RH, Hammond PB. D-lactic acidosis of ruminants. Ann N Y Acad Sci. 1965;119(3):1109–32.\nKowlgi NG, Chhabra L. D-lactic acidosis: an underrecognized complication of short bowel syndrome. Gastroenterol Res Pract. 2015;2015:476215. doi:10.1155\u002F2015\u002F476215.\nKu W, Lau D, Huen KF. Probiotics provoked D-lactic acidosis in short bowel syndrome: case report and literature review. H K J Paediatr. 2006;11:246–54.\nWinkler MF, Smith CE. Clinical, social, and economic impacts of home parenteral nutrition dependence in short bowel syndrome. JPEN J Parenter Enteral Nutr. 2014;38(1 Suppl):32S–7. doi:10.1177\u002F0148607113517717.\nKalaitzakis E, Carlsson E, Josefsson A, Bosaeus I. Quality of life in short-bowel syndrome: impact of fatigue and gastrointestinal symptoms. Scand J Gastroenterol. 2008;43(9):1057–65. doi:10.1080\u002F00365520802078325.\nScolapio JS, Savoy AD, Kaplan J, Burger CD, Lin SC. Sleep patterns of cyclic parenteral nutrition, a pilot study: are there sleepless nights? JPEN J Parenter Enteral Nutr. 2002;26(3):214–7.\nFeagan BG, Bala M, Yan S, Olson A, Hanauer S. Unemployment and disability in patients with moderately to severely active Crohn’s disease. J Clin Gastroenterol. 2005;39(5):390–5.\nMarri SR, Buchman AL. The education and employment status of patients with inflammatory bowel diseases. Inflamm Bowel Dis. 2005;11(2):171–7.\nJeppesen PB, Pertkiewicz M, Forbes A, Pironi L, Gabe SM, Joly F, et al. Quality of life in patients with short bowel syndrome treated with the new glucagon-like peptide-2 analogue teduglutide—analyses from a randomised, placebo-controlled study. Clin Nutr. 2013;32(5):713–21. doi:10.1016\u002Fj.clnu.2013.03.016.\nKunkel D, Basseri B, Low K, Lezcano S, Soffer EE, Conklin JL, et al. Efficacy of the glucagon-like peptide-1 agonist exenatide in the treatment of short bowel syndrome. Neurogastroenterol Motil. 2011;23(8):739–e328. doi:10.1111\u002Fj.1365-2982.2011.01723.x.\nMadsen KB, Askov-Hansen C, Naimi RM, Brandt CF, Hartmann B, Holst JJ, et al. Acute effects of continuous infusions of glucagon-like peptide (GLP)-1, GLP-2 and the combination (GLP-1+GLP-2) on intestinal absorption in short bowel syndrome (SBS) patients. A placebo-controlled study. Regul Pept. 2013;184:30–9. doi:10.1016\u002Fj.regpep.2013.03.025.\nJones BA, Hull MA, Potanos KM, Zurakowski D, Fitzgibbons SC, Ching YA, et al. Report of 111 consecutive patients enrolled in the International Serial Transverse Enteroplasty (STEP) Data Registry: a retrospective observational study. J Am Coll Surg. 2013;216(3):438–46. doi:10.1016\u002Fj.jamcollsurg.2012.12.018.\nBianchi A. Intestinal lengthening: an experimental and clinical review. J R Soc Med. 1984;77 Suppl 3:35–41.\nGarcia-Roca R, Tzvetanov IG, Jeon H, Hetterman E, Oberholzer J, Benedetti E. Successful living donor intestinal transplantation in cross-match positive recipients: initial experience. World J Gastrointest Surg. 2016;8(1):101–5. doi:10.4240\u002Fwjgs.v8.i1.101.",{"VOID":1511},"10.1007\u002Fs11894-016-0511-3","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs11894-016-0511-3",[1514,1529,1542,1555],{"id":1515,"sortIndex":32,"researcher":28,"roles":1516,"affiliations":1517,"properties":1526,"displayName":1528,"givenName":28,"familyName":28},"ca2da375-c6d7-4190-ba81-fd9332900a4f",[950],[1518],{"id":1519,"sortIndex":32,"affiliation":1520,"properties":28},"06358693-1dd2-4f32-8dcc-39ae5a7fdcea",{"id":1519,"createTime":28,"updateTime":28,"relativeEntities":1521,"slug":28,"properties":1522,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1525,"statistic":28},[],{"title":1523},{"VI":1524},"Intestinal Rehabilitation and Transplant Center, Departments of Medicine and Surgery, University of Illinois at Chicago and Chicago Veterans Administration Medical Center (West Side Division), Chicago, USA",[],{"title":1527},{"VI":1528},"Robert E. Carroll",{"id":1530,"sortIndex":40,"researcher":28,"roles":1531,"affiliations":1532,"properties":1539,"displayName":1541,"givenName":28,"familyName":28},"8159def3-751c-423c-88ac-0f3da0698529",[950],[1533],{"id":1519,"sortIndex":32,"affiliation":1534,"properties":28},{"id":1519,"createTime":28,"updateTime":28,"relativeEntities":1535,"slug":28,"properties":1536,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1538,"statistic":28},[],{"title":1537},{"VI":1524},[],{"title":1540},{"VI":1541},"Enrico Benedetti",{"id":1543,"sortIndex":123,"researcher":28,"roles":1544,"affiliations":1545,"properties":1552,"displayName":1554,"givenName":28,"familyName":28},"eae64ce8-bb53-40e3-a988-d7f9a3e63153",[950],[1546],{"id":1519,"sortIndex":32,"affiliation":1547,"properties":28},{"id":1519,"createTime":28,"updateTime":28,"relativeEntities":1548,"slug":28,"properties":1549,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1551,"statistic":28},[],{"title":1550},{"VI":1524},[],{"title":1553},{"VI":1554},"Joseph P. Schowalter",{"id":1556,"sortIndex":42,"researcher":28,"roles":1557,"affiliations":1558,"properties":1565,"displayName":1567,"givenName":28,"familyName":28},"98ee97a3-0445-46d6-8de9-6df539fed63c",[950],[1559],{"id":1519,"sortIndex":32,"affiliation":1560,"properties":28},{"id":1519,"createTime":28,"updateTime":28,"relativeEntities":1561,"slug":28,"properties":1562,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1564,"statistic":28},[],{"title":1563},{"VI":1524},[],{"title":1566},{"VI":1567},"Alan L. Buchman",{"url":1512,"publisher":1569,"properties":1603},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1570,"slug":872,"properties":1571,"entityType":25,"verifyStatus":882,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1575,"manageAffiliations":1584,"indexDatabases":1590,"url":28,"thumbnailPath":28,"statistic":1598,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1572,"title":1573,"eissn":1574},{"VOID":877},{"EN":879},{"VOID":875},[1576,1580],{"id":885,"createTime":28,"updateTime":28,"relativeEntities":1577,"label":1578,"description":1579,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":888},{},{"id":891,"createTime":28,"updateTime":28,"relativeEntities":1581,"label":1582,"description":1583,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":894},{},[1585],{"id":898,"createTime":28,"updateTime":28,"relativeEntities":1586,"slug":28,"properties":1587,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1589,"statistic":28},[],{"title":1588},{"EN":902},[],[1591],{"id":906,"indexDatabase":1592,"url":912,"indexYears":913,"academicFieldIds":1597,"indexDatabaseRanking":917},{"id":786,"createTime":28,"updateTime":28,"relativeEntities":1593,"label":1594,"description":1595,"key":792,"publicationTags":1596,"standard":28},[],{"EN":789,"VI":789},{"EN":789,"VI":791},[794],[915,916],{"impactFactor":32,"impactFactorByYear":1599,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":920,"totalPublicationByYear":1600,"totalCitation":32,"totalCitationByYear":1601,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":1602,"hindexLast5Year":32,"hindex":32},{},{"1996":40,"1999":196,"2000":139,"2001":142,"2002":150,"2003":200,"2004":280,"2005":152,"2006":352,"2007":150,"2008":208,"2009":139,"2010":279,"2011":132,"2012":278,"2013":139,"2014":147,"2015":136,"2016":352,"2017":148,"2018":132,"2019":147,"2020":69,"2021":146,"2022":51,"2023":142,"2024":45},{},{},{"pages":1604,"volume":1606},{"VOID":1605},"1-13",{"VOID":1607},"18","2016-06-20",2016,[917],{"id":1612,"createTime":1613,"updateTime":1614,"relativeEntities":1615,"slug":1616,"properties":1617,"entityType":943,"verifyStatus":26,"verifyTime":1614,"verifyNote":1044,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1624,"fullTextUrl":28,"authors":1625,"publicationType":984,"publisherRelationship":1641,"citationCount":28,"citationInfo":28,"publishDate":1681,"publishYear":1682,"citationAnalyzeStatus":882,"lastCitationAnalyze":28,"indexDatabases":1683,"openAccess":28,"references":28,"isForceReanalyzing":1028},"01bef8ef-7600-407e-acdd-852f3d3349a6","2023-12-20T15:04:02.210+00:00","2025-02-12T23:37:15.771+00:00",[],"Crying-in-infant-GERD-Acid-or-volume-Heartburn-or-dyspepsia-",{"title":1618,"references":1620,"doi":1622},{"EN":1619},"Crying in infant GERD: Acid or volume? Heartburn or dyspepsia?",{"VOID":1621},"Ryan P, Lander M, Ong TH, Shepherd R: When does reflux oesophagitis occur with gastro-oesophageal reflux in infants? A clinical and endoscopic study and correlation with outcome. Aust Paediatr J 1983, 19:90–93.\nOrenstein SR, Shalaby TM, Cohn JF: Reflux symptoms in 100 normal infants: diagnostic validity of the Infant Gastroesophageal Reflux Questionnaire. Clin Pediatr 1996, 35:607–614.\nOmari TI, Haslam RR, Lundborg P, Davidson GP: Effect of omeprazole on acid gastroesophageal reflux and gastric acidity in preterm infants with pathological acid reflux. J Pediatr Gastroenterol Nutr 2007, 44:41–44.\nMoore DJ, Tau BS, Lines DR, et al.: Double-blind placebo-controlled trial of omeprazole in irritable infants with gastroesophageal reflux. J Pediatr 2003, 143:219–223.\nOmari T, Davidson G, Bondarov P, et al.: Pharmacokinetics and acid-suppressive effects of esomeprazole in infants 1–24 months old with symptoms of gastroesophageal reflux disease. J Pediatr Gastroenterol Nutr 2007, 45:530–537.\nTran A, Rey E, Pons G, et al.: Pharmacokinetic-pharmacodynamic study of oral lansoprazole in children. Clin Pharmacol Ther 2002, 71:359–367.\nAndersson T, Gothberg G, Friberg L, et al.: Pharmacokinetics of intravenous omeprazole in neonates and infants [abstract]. J Pediatr Gastroenterol Nutr 2001, 33:424.\nWessel MA, Cobb CJ, Jackson EB, et al.: Paroxysmal fussing in infancy, sometimes called “colic.” Pediatrics 1954, 14:421.\nTreem WR: Infant colic. Pediatr Clin North Am 1994, 41:1121–1138.\nMatheson I, Rivrud GN: The effect of smoking on lactation and infantile colic. JAMA 1989, 261:42–43.\nSaid G, Patois E, Lellouch J: Infantile colic and parental smoking. Br Med J (Clin Res Ed) 1984, 289:660.\nSutphen JL: Is it colic or is it gastroesophageal reflux? J Pediatr Gastroenterol Nutr 2001, 33:110–111.\nBarron JJ, Tan H, Spalding J, et al.: Proton pump inhibitor utilization patterns in infants. J Pediatr Gastroenterol Nutr 2007, 45:421–427.\nOrenstein SR, Hassall E: Infants and proton pump inhibitors: tribulations, no trials [editorial]. J Pediatr Gastroenterol Nutr 2007, 45:395–398.\nFeranchak AP, Orenstein SR, Cohn JF: Behaviors associated with onset of gastroesophageal reflux episodes in infants: prospective study using split-screen video and pH probe. Clin Pediatr 1994, 33:654–662.\nCondino AA, Sondheimer J, Pan Z, et al.: Evaluation of infantile acid and nonacid gastroesophageal reflux using combined pH monitoring and impedance measurement. J Pediatr Gastroenterol Nutr 2006, 42:16–21.\nRavelli A, Villanacci V, Ruzzenenti N, et al.: Dilated intercellular spaces: a major morphological feature of esophagitis. J Pediatr Gastroenterol Nutr 2006, 42:510–515.\nOrlando RC: Current understanding of the mechanisms of gastro-oesophageal reflux disease [review]. Drugs 2006, 66(Suppl 1):1–5.\nSabri MT, Hussain SZ, Shalaby TM, Orenstein SR: Morphometric histology for infant gastroesophageal reflux disease: evaluation of reliability in 497 esophageal biopsies. J Pediatr Gastroenterol Nutr 2007, 44:27–34.\nOrenstein SR: Infantile reflux: different from adult reflux. Am J Med 1997, 103(5A):114S–119S.\nOrenstein SR, Dent J, Deneault LG, et al.: Regurgitant reflux, vs. non-regurgitant reflux, is preceded by rectus abdominis contraction in infants. Neurogastroenterol Motil 1994, 6:271–277.\nBlack DD, Haggitt RC, Orenstein SR, Whitington PF: Esophagitis in infants: morphometric histologic diagnosis and correlation with measures of gastroesophageal reflux. Gastroenterology 1990, 98:1408–1414.\nShalaby TM, Orenstein SR: Efficacy of telephone teaching of conservative therapy for infants with symptomatic gastroesophageal reflux referred by pediatricians to pediatric gastroenterologists. J Pediatr 2003, 142:57–61.\nOrenstein SR, McGowan JD: Efficacy of conservative therapy as taught in the primary care setting for symptoms suggesting infant gastroesophageal reflux: prospective validated assessment by the I-GERQ-R. J Pediatr 2008, 152:310–314.",{"VOID":1623},"10.1007\u002Fs11894-008-0080-1","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs11894-008-0080-1",[1626],{"id":1627,"sortIndex":32,"researcher":28,"roles":1628,"affiliations":1629,"properties":1638,"displayName":1640,"givenName":28,"familyName":28},"03da20b8-d7c7-46e5-baba-adf02552c598",[950],[1630],{"id":1631,"sortIndex":32,"affiliation":1632,"properties":28},"0a2a8265-4ad9-466a-8874-90d87538bf99",{"id":1631,"createTime":28,"updateTime":28,"relativeEntities":1633,"slug":28,"properties":1634,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1637,"statistic":28},[],{"title":1635},{"VI":1636},"University of Pittsburgh School of Medicine, Pittsburgh, USA",[],{"title":1639},{"VI":1640},"Susan R. Orenstein",{"url":1624,"publisher":1642,"properties":1676},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1643,"slug":872,"properties":1644,"entityType":25,"verifyStatus":882,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1648,"manageAffiliations":1657,"indexDatabases":1663,"url":28,"thumbnailPath":28,"statistic":1671,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1645,"title":1646,"eissn":1647},{"VOID":877},{"EN":879},{"VOID":875},[1649,1653],{"id":885,"createTime":28,"updateTime":28,"relativeEntities":1650,"label":1651,"description":1652,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":888},{},{"id":891,"createTime":28,"updateTime":28,"relativeEntities":1654,"label":1655,"description":1656,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":894},{},[1658],{"id":898,"createTime":28,"updateTime":28,"relativeEntities":1659,"slug":28,"properties":1660,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1662,"statistic":28},[],{"title":1661},{"EN":902},[],[1664],{"id":906,"indexDatabase":1665,"url":912,"indexYears":913,"academicFieldIds":1670,"indexDatabaseRanking":917},{"id":786,"createTime":28,"updateTime":28,"relativeEntities":1666,"label":1667,"description":1668,"key":792,"publicationTags":1669,"standard":28},[],{"EN":789,"VI":789},{"EN":789,"VI":791},[794],[915,916],{"impactFactor":32,"impactFactorByYear":1672,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":920,"totalPublicationByYear":1673,"totalCitation":32,"totalCitationByYear":1674,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":1675,"hindexLast5Year":32,"hindex":32},{},{"1996":40,"1999":196,"2000":139,"2001":142,"2002":150,"2003":200,"2004":280,"2005":152,"2006":352,"2007":150,"2008":208,"2009":139,"2010":279,"2011":132,"2012":278,"2013":139,"2014":147,"2015":136,"2016":352,"2017":148,"2018":132,"2019":147,"2020":69,"2021":146,"2022":51,"2023":142,"2024":45},{},{},{"pages":1677,"volume":1679},{"VOID":1678},"433-436",{"VOID":1680},"10","2008-10-16",2008,[917],{"id":1685,"createTime":1686,"updateTime":1687,"relativeEntities":1688,"slug":1689,"properties":1690,"entityType":943,"verifyStatus":26,"verifyTime":1687,"verifyNote":1044,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1699,"fullTextUrl":28,"authors":1700,"publicationType":984,"publisherRelationship":1757,"citationCount":28,"citationInfo":28,"publishDate":1797,"publishYear":1798,"citationAnalyzeStatus":882,"lastCitationAnalyze":28,"indexDatabases":1799,"openAccess":28,"references":28,"isForceReanalyzing":1028},"01f1a94e-42e7-49a5-81b4-65a9e6d757fb","2024-01-25T10:47:59.841+00:00","2024-09-18T10:49:30.032+00:00",[],"Bleeding-Lesion-of-the-Small-Bowel-an-Extensive-Update-Leaving-No-Stone-Unturned",{"abstract":1691,"title":1693,"references":1695,"doi":1697},{"EN":1692},"Gastrointestinal bleeding originating from the small bowel (SB) poses a challenge to the treating gastroenterologist. Once diagnosed, management is not a walk in the park either. This review intends to summarize the current state-of-the-art evidence in a complete way with special attention for vascular and ulcerative lesions, to provide the reader with a clinical guide and flow chart towards SB bleeding. Absence of SB bleeding lesions on CE does not directly yield better prognosis; although having a lower rebleeding rate the first 2 years, rebleeding in the long term is high. Push enteroscopy can play an early role in patients with SB bleeding if suspicion of angioectasia is high, since these lesions tend to be located in the proximal SB. Endoscopic management of angioectasia is, however, difficult and shows poor results. Capsule endoscopy (CE) or device-assisted enteroscopy (DAE) remain the diagnostic mainstay in SB bleeding, choosing one over the other based upon patient characteristics and expected lesions.",{"EN":1694},"Bleeding Lesion of the Small Bowel: an Extensive Update Leaving No Stone Unturned",{"VOID":1696},"Peery AF, Crockett SD, Barritt AS, Dellon ES, Eluri S, Gangarosa LM, et al. Burden of gastrointestinal, liver, and pancreatic diseases in the United States. Gastroenterology. 2015;149(7):1731–41 e1733. https:\u002F\u002Fdoi.org\u002F10.1053\u002Fj.gastro.2015.08.045.\nKim BS, Li BT, Engel A, Samra JS, Clarke S, Norton ID, et al. Diagnosis of gastrointestinal bleeding: a practical guide for clinicians. World J Gastrointest Pathophysiol. 2014;5(4):467–78. https:\u002F\u002Fdoi.org\u002F10.4291\u002Fwjgp.v5.i4.467.\nSharara AI, Rockey DC. Gastroesophageal variceal hemorrhage. N Engl J Med. 2001;345(9):669–81. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMra003007.\nOkazaki H, Fujiwara Y, Sugimori S, Nagami Y, Kameda N, Machida H, et al. Prevalence of mid-gastrointestinal bleeding in patients with acute overt gastrointestinal bleeding: multi-center experience with 1,044 consecutive patients. J Gastroenterol. 2009;44(6):550–5. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00535-009-0039-5.\nCommittee ASoP, Gurudu SR, Bruining DH, Acosta RD, Eloubeidi MA, Faulx AL, et al. The role of endoscopy in the management of suspected small-bowel bleeding. Gastrointest Endosc. 2017;85(1):22–31. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.gie.2016.06.013.\nZhang BL, Chen CX, Li YM. Capsule endoscopy examination identifies different leading causes of obscure gastrointestinal bleeding in patients of different ages. Turk J Gastroenterol. 2012;23(3):220–5. https:\u002F\u002Fdoi.org\u002F10.4318\u002Ftjg.2012.0338.\nYung DE, Rondonotti E, Giannakou A, Avni T, Rosa B, Toth E, et al. Capsule endoscopy in young patients with iron deficiency anaemia and negative bidirectional gastrointestinal endoscopy. United European Gastroenterol J. 2017;5(7):974–81. https:\u002F\u002Fdoi.org\u002F10.1177\u002F2050640617692501.\nLi L, Chen C, Li Y, Zhang B. The role of capsule endoscopy in the diagnosis and treatment of obscure gastrointestinal bleeding in older individuals. Eur J Gastroenterol Hepatol. 2016;28(12):1425–30. https:\u002F\u002Fdoi.org\u002F10.1097\u002FMEG.0000000000000737.\n• Bosch X, Montori E, Guerra-Garcia M, Costa-Rodriguez J, Quintanilla MH, Tolosa-Chapasian PE, et al. A comprehensive evaluation of the gastrointestinal tract in iron-deficiency anemia with predefined hemoglobin below 9mg\u002FdL: a prospective cohort study. Digestive Liver Dis. 2017;49(4):417–26. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.dld.2016.12.013. This large study confirms the importance of diffuse angioectasia as disease entity, as it is, just like GI cancer, correlated with the lowest hemoglobin values in GI bleeding.\nHosoe N, Matsukawa S, Kanno Y, Naganuma M, Imaeda H, Ida Y, et al. Cross-sectional small intestinal surveillance of maintenance hemodialysis patients using video capsule endoscopy: SCHEMA study. Endosc Int Open. 2016;4(5):E589–96. https:\u002F\u002Fdoi.org\u002F10.1055\u002Fs-0042-105203.\n• Draper KV, Huang RJ, Gerson LB. GI bleeding in patients with continuous-flow left ventricular assist devices: a systematic review and meta-analysis. Gastrointestinal Endoscopy. 2014;80(3):435–446 e431. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.gie.2014.03.040. This systematic review and meta-analysis creates awareness of GI bleeding due to GI angioectasia in patients with Left Ventricular Assist Devices.\n•• Sakai E, Endo H, Taniguchi L, Hata Y, Ezuka A, Nagase H, et al. Factors predicting the presence of small bowel lesions in patients with obscure gastrointestinal bleeding. Dig Endoscopy. 2013;25(4):412–20. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fden.12002. This study emphasizes the impact of nonsteroidal anti-inflammatory drugs, low-dose aspirin, and proton-pump inhibitor use on GI bleeding.\nOkamoto J, Tominaga K, Sugimori S, Kato K, Minamino H, Ominami M, et al. Comparison of risk factors between small intestinal ulcerative and vascular lesions in occult versus overt obscure gastrointestinal bleeding. Dig Dis Sci. 2016;61(2):533–41. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs10620-015-3904-5.\nNagata N, Niikura R, Yamada A, Sakurai T, Shimbo T, Kobayashi Y, et al. Acute middle gastrointestinal bleeding risk associated with NSAIDs, antithrombotic drugs, and PPIs: a multicenter case-control study. PLoS One. 2016;11(3):e0151332. https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.pone.0151332.\n• Van de Bruaene C, Hindryckx P, Snauwaert C, Dooremont D, Vanduyfhuys B, Vandenabeele L, et al. The predictive value of negative capsule endoscopy for the indication of Obscure Gastrointestinal Bleeding: no reassurance in the long term. Acta Gastroenterol Belg. 2016;79(4):405–13. Our recently published study shows the outcome of negative capsule endoscopies in patients with gastrointestinal bleeding. High rebleeding rates were found in the long term and negative capsule endoscopy should not reassure the treating gastroenterologist.\nHoedemaker RA, Westerhof J, Weersma RK, Koornstra JJ. Non-small-bowel abnormalities identified during small bowel capsule endoscopy. World J Gastroenterol WJG. 2014;20(14):4025–9. https:\u002F\u002Fdoi.org\u002F10.3748\u002Fwjg.v20.i14.4025.\nFry LC, Bellutti M, Neumann H, Malfertheiner P, Monkemuller K. Incidence of bleeding lesions within reach of conventional upper and lower endoscopes in patients undergoing double-balloon enteroscopy for obscure gastrointestinal bleeding. Aliment Pharmacol Ther. 2009;29(3):342–9. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1365-2036.2008.03888.x.\nPennazio M, Spada C, Eliakim R, Keuchel M, May A, Mulder CJ, et al. Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy. 2015;47(4):352–86. https:\u002F\u002Fdoi.org\u002F10.1055\u002Fs-0034-1391855.\n• Van de Bruaene C, De Looze D, Hindryckx P. Small bowel capsule endoscopy: where are we after almost 15 years of use? World J Gastrointest Endosc. 2015;7(1):13–36. https:\u002F\u002Fdoi.org\u002F10.4253\u002Fwjge.v7.i1.13. This review encompasses every possible aspect of capsule endoscopy in-depth.\nOu G, Shahidi N, Galorport C, Takach O, Lee T, Enns R. Effect of longer battery life on small bowel capsule endoscopy. World J Gastroenterol: WJG. 2015;21(9):2677–82. https:\u002F\u002Fdoi.org\u002F10.3748\u002Fwjg.v21.i9.2677.\nMonteiro S, de Castro FD, Carvalho PB, Moreira MJ, Rosa B, Cotter J. PillCam((R)) SB3 capsule: does the increased frame rate eliminate the risk of missing lesions? World J Gastroenterol: WJG. 2016;22(10):3066–8. https:\u002F\u002Fdoi.org\u002F10.3748\u002Fwjg.v22.i10.3066.\nKoulaouzidis A, Rondonotti E, Giannakou A, Plevris JN. Diagnostic yield of small-bowel capsule endoscopy in patients with iron-deficiency anemia: a systematic review. Gastrointest Endosc. 2012;76(5):983–92. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.gie.2012.07.035.\nShahidi NC, Ou G, Svarta S, Law JK, Kwok R, Tong J, et al. Factors associated with positive findings from capsule endoscopy in patients with obscure gastrointestinal bleeding. Clin Gastroenterol Hepatol. 2012;10(12):1381–5. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.cgh.2012.08.035.\nNennstiel S, Machanek A, von Delius S, Neu B, Haller B, Abdelhafez M, et al. Predictors and characteristics of angioectasias in patients with obscure gastrointestinal bleeding identified by video capsule endoscopy. United European Gastroenterol J. 2017;5(8):1129–35. https:\u002F\u002Fdoi.org\u002F10.1177\u002F2050640617704366.\nSulbaran M, de Moura E, Bernardo W, Morais C, Oliveira J, Bustamante-Lopez L, et al. Overtube-assisted enteroscopy and capsule endoscopy for the diagnosis of small-bowel polyps and tumors: a systematic review and meta-analysis. Endosc Int Open. 2016;4(2):E151–63. https:\u002F\u002Fdoi.org\u002F10.1055\u002Fs-0041-108261.\nRahman M, Akerman S, DeVito B, Miller L, Akerman M, Sultan K. Comparison of the diagnostic yield and outcomes between standard 8 h capsule endoscopy and the new 12 h capsule endoscopy for investigating small bowel pathology. World J Gastroenterol. 2015;21(18):5542–7. https:\u002F\u002Fdoi.org\u002F10.3748\u002Fwjg.v21.i18.5542.\nPioche M, Gaudin JL, Filoche B, Jacob P, Lamouliatte H, Lapalus MG, et al. Prospective, randomized comparison of two small-bowel capsule endoscopy systems in patients with obscure GI bleeding. Gastrointest Endosc. 2011;73(6):1181–8. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.gie.2011.02.011.\nPioche M, Vanbiervliet G, Jacob P, Duburque C, Gincul R, Filoche B, et al. Prospective randomized comparison between axial- and lateral-viewing capsule endoscopy systems in patients with obscure digestive bleeding. Endoscopy. 2014;46(6):479–84. https:\u002F\u002Fdoi.org\u002F10.1055\u002Fs-0033-1358832.\n•• Tontini GE, Wiedbrauck F, Cavallaro F, Koulaouzidis A, Marino R, Pastorelli L, et al. Small-bowel capsule endoscopy with panoramic view: results of the first multicenter, observational study (with videos). Gastrointest Endosc. 2017;85(2):401–408 e402. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.gie.2016.07.063. In this study, the diagnostic yield and safety of 360° panoramic-view cameras was found to be similar to forward-viewing capsules.\nLepileur L, Dray X, Antonietti M, Iwanicki-Caron I, Grigioni S, Chaput U, et al. Factors associated with diagnosis of obscure gastrointestinal bleeding by video capsule enteroscopy. Clin Gastroenterol Hepatol. 2012;10(12):1376–80. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.cgh.2012.05.024.\nSidhu R, Sanders DS, Kapur K, Leeds JS, McAlindon ME. Factors predicting the diagnostic yield and intervention in obscure gastrointestinal bleeding investigated using capsule endoscopy. J Gastrointest Liver Dis. 2009;18(3):273–8.\nKim SH, Keum B, Chun HJ, Yoo IK, Lee JM, Lee JS, et al. Efficacy and implications of a 48-h cutoff for video capsule endoscopy application in overt obscure gastrointestinal bleeding. Endosc Int Open. 2015;3(4):E334–8. https:\u002F\u002Fdoi.org\u002F10.1055\u002Fs-0034-1391852.\nSung JJ, Tang RS, Ching JY, Rainer TH, Lau JY. Use of capsule endoscopy in the emergency department as a triage of patients with GI bleeding. Gastrointest Endosc. 2016;84(6):907–13. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.gie.2016.04.043.\nMaeda Y, Moribata K, Deguchi H, Inoue I, Maekita T, Iguchi M, et al. Video capsule endoscopy as the initial examination for overt obscure gastrointestinal bleeding can efficiently identify patients who require double-balloon enteroscopy. BMC Gastroenterol. 2015;15:132. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12876-015-0362-7.\nChalazan B, Gostout CJ, Song LM, Enders FT, Rajan E. Use of capsule small bowel transit time to determine the optimal enteroscopy approach. Gastroenterol Res. 2012;5(2):39–44. https:\u002F\u002Fdoi.org\u002F10.4021\u002Fgr404w.\n• Rezapour M, Amadi C, Gerson LB. Retention associated with video capsule endoscopy: systematic review and meta-analysis. Gastrointestinal Endoscopy. 2017;85(6):1157–1168 e1152. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.gie.2016.12.024. This systematic review and meta-analysis focuses on the retention of capsules in patients with small bowel bleeding undergoing capsule endoscopy, being ~ 2%. Retention rates can be decreased by 50% using patency capsules or CT enterography.\nBouchard S, Ibrahim M, Van Gossum A. Video capsule endoscopy: perspectives of a revolutionary technique. World J Gastroenterol. 2014;20(46):17330–44. https:\u002F\u002Fdoi.org\u002F10.3748\u002Fwjg.v20.i46.17330.\nLaine L, Sahota A, Shah A. Does capsule endoscopy improve outcomes in obscure gastrointestinal bleeding? Randomized trial versus dedicated small bowel radiography. Gastroenterology. 2010;138(5):1673–1680 e1671; quiz e1611–1672. https:\u002F\u002Fdoi.org\u002F10.1053\u002Fj.gastro.2010.01.047.\nSegarajasingam DS, Hanley SC, Barkun AN, Waschke KA, Burtin P, Parent J, et al. Randomized controlled trial comparing outcomes of video capsule endoscopy with push enteroscopy in obscure gastrointestinal bleeding. Can J Gastroenterol Hepatol. 2015;29(2):85–90.\nHolleran GE, Barry SA, Thornton OJ, Dobson MJ, McNamara DA. The use of small bowel capsule endoscopy in iron deficiency anaemia: low impact on outcome in the medium term despite high diagnostic yield. Eur J Gastroenterol Hepatol. 2013;25(3):327–32. https:\u002F\u002Fdoi.org\u002F10.1097\u002FMEG.0b013e32835b7d3a.\nChen WG, Shan GD, Zhang H, Yang M, L L, Yue M, et al. Double-balloon enteroscopy in small bowel diseases: eight years single-center experience in China. Medicine (Baltimore). 2016;95(42):e5104. https:\u002F\u002Fdoi.org\u002F10.1097\u002FMD.0000000000005104.\nAniwan S, Viriyautsahakul V, Rerknimitr R, Angsuwatcharakon P, Kongkam P, Treeprasertsuk S, et al. Urgent double balloon endoscopy provides higher yields than non-urgent double balloon endoscopy in overt obscure gastrointestinal bleeding. Endosc Int Open. 2014;2(2):E90–5. https:\u002F\u002Fdoi.org\u002F10.1055\u002Fs-0034-1365543.\nLipka S, Rabbanifard R, Kumar A, Brady P. Single versus double balloon enteroscopy for small bowel diagnostics: a systematic review and meta-analysis. J Clin Gastroenterol. 2015;49(3):177–84. https:\u002F\u002Fdoi.org\u002F10.1097\u002FMCG.0000000000000274.\nTeshima CW, Kuipers EJ, van Zanten SV, Mensink PB. Double balloon enteroscopy and capsule endoscopy for obscure gastrointestinal bleeding: an updated meta-analysis. J Gastroenterol Hepatol. 2011;26(5):796–801. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1440-1746.2010.06530.x.\nAniwan S, Viriyautsahakul V, Angsuwatcharakon P, Kongkam P, Treeprasertsuk S, Rerknimitr R, et al. Comparison of urgent video capsule endoscopy and urgent double-balloon endoscopy in massive obscure gastrointestinal bleeding. Hepato-Gastroenterology. 2014;61(135):1990–4.\nPinto-Pais T, Pinho R, Rodrigues A, Fernandes C, Ribeiro I, Fraga J, et al. Emergency single-balloon enteroscopy in overt obscure gastrointestinal bleeding: efficacy and safety. United Eur Gastroenterol J. 2014;2(6):490–6. https:\u002F\u002Fdoi.org\u002F10.1177\u002F2050640614554850.\n• Nelson KK, Lipka S, Davis-Yadley AH, Rodriguez AC, Doraiswamy V, Rabbanifard R, et al. Timing of single balloon enteroscopy: significant or not? Endosc Int Open. 2016;4(7):E761–6. https:\u002F\u002Fdoi.org\u002F10.1055\u002Fs-0042-108189. Diagnostic and therapeutic yield of SBE within or after 24 hours were similar, yet hospital stay was significantly shorter if SBE was performed early.\nRahmi G, Samaha E, Vahedi K, Ponchon T, Fumex F, Filoche B, et al. Multicenter comparison of double-balloon enteroscopy and spiral enteroscopy. J Gastroenterol Hepatol. 2013;28(6):992–8. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fjgh.12188.\nDespott EJ, Murino A, Bourikas L, Nakamura M, Ramachandra V, Fraser C. A prospective comparison of performance during back-to-back, anterograde manual spiral enteroscopy and double-balloon enteroscopy. Digest Liver Dis. 2015;47(5):395–400. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.dld.2015.02.003.\n•• Baniya R, Upadhya S, Subedi SC, Khan J, Sharma P, Mohammed TS, et al. Balloon enteroscopy versus spiral enteroscopy for small-bowel disorders: a systematic review and meta-analysis. Gastrointest Endosc. 2017; https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.gie.2017.06.015. This recently published systematic review and meta-analysis shows no difference in balloon enteroscopy and spiral enteroscopy, regarding diagnostic and therapeutic outcomes. However, spiral enteroscopy is associated with shorter procedure times.\nFoutch PG, Sawyer R, Sanowski RA. Push-enteroscopy for diagnosis of patients with gastrointestinal bleeding of obscure origin. Gastrointest Endosc. 1990;36(4):337–41. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0016-5107(90)71060-7.\n• Plotkin E, Imaeda A. mall intestinal angioectasias are not randomly distributed in the small bowel and most may be reached by push enteroscopy. J Clin Gastroenterol. 2016;50(7):561–5. https:\u002F\u002Fdoi.org\u002F10.1097\u002FMCG.0000000000000425. Although more and more replaced by balloon-assisted endoscopy, push enteroscopy might be of use in patients at risk of bleeding GI angioectasia, since these lesions were found to be located in the proximal part of the small bowel.\nDouard R, Wind P, Berger A, Maniere T, Landi B, Cellier C, et al. Role of intraoperative enteroscopy in the management of obscure gastointestinal bleeding at the time of video-capsule endoscopy. Am J Surg. 2009;198(1):6–11. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.amjsurg.2008.06.036.\nBonnet S, Douard R, Malamut G, Cellier C, Wind P. Intraoperative enteroscopy in the management of obscure gastrointestinal bleeding. Digest Liver Dis. 2013;45(4):277–84. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.dld.2012.07.003.\nWang Z, Chen JQ, Liu JL, Qin XG, Huang Y. CT enterography in obscure gastrointestinal bleeding: a systematic review and meta-analysis. J Med Imaging Radiat Oncol. 2013;57(3):263–73. https:\u002F\u002Fdoi.org\u002F10.1111\u002F1754-9485.12035.\nLimsrivilai J, Srisajjakul S, Pongprasobchai S, Leelakusolvong S, Tanwandee T. A prospective blinded comparison of video capsule endoscopy versus computed tomography enterography in potential small bowel bleeding: clinical utility of computed tomography enterography. J Clin Gastroenterol. 2016; https:\u002F\u002Fdoi.org\u002F10.1097\u002FMCG.0000000000000639.\nHeo HM, Park CH, Lim JS, Lee JH, Kim BK, Cheon JH, et al. The role of capsule endoscopy after negative CT enterography in patients with obscure gastrointestinal bleeding. Eur Radiol. 2012;22(6):1159–66. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00330-011-2374-1.\nHe B, Gong S, Hu C, Fan J, Qian J, Huang S, et al. Obscure gastrointestinal bleeding: diagnostic performance of 64-section multiphase CT enterography and CT angiography compared with capsule endoscopy. Br J Radiol. 2014;87(1043):20140229. https:\u002F\u002Fdoi.org\u002F10.1259\u002Fbjr.20140229.\nVan Weyenberg SJ, Bouman K, Jacobs MA, Halloran BP, Van der Peet DL, Mulder CJ, et al. Comparison of MR enteroclysis with video capsule endoscopy in the investigation of small-intestinal disease. Abdom Imaging. 2013;38(1):42–51. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00261-012-9892-4.\nWiarda BM, Heine DG, Mensink P, Stolk M, Dees J, Hazenberg HJ, et al. Comparison of magnetic resonance enteroclysis and capsule endoscopy with balloon-assisted enteroscopy in patients with obscure gastrointestinal bleeding. Endoscopy. 2012;44(7):668–73. https:\u002F\u002Fdoi.org\u002F10.1055\u002Fs-0032-1309386.\nTseng CM, Lin IC, Chang CY, Wang HP, Chen CC, Mo LR, et al. Role of computed tomography angiography on the management of overt obscure gastrointestinal bleeding. PLoS One. 2017;12(3):e0172754. https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.pone.0172754.\nWildgruber M, Wrede CE, Zorger N, Muller-Wille R, Hamer OW, Zeman F, et al. Computed tomography versus digital subtraction angiography for the diagnosis of obscure gastrointestinal bleeding. Eur J Radiol. 2017;88:8–14. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ejrad.2016.12.029.\nGrady E. Gastrointestinal bleeding scintigraphy in the early 21st century. J Nucl Med. 2016;57(2):252–9. https:\u002F\u002Fdoi.org\u002F10.2967\u002Fjnumed.115.157289.\nGerson L, Kamal A. Cost-effectiveness analysis of management strategies for obscure GI bleeding. Gastrointest Endosc. 2008;68(5):920–36. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.gie.2008.01.035.\nMarmo R, Rotondano G, Rondonotti E, de Franchis R, D’Inca R, Vettorato MG, et al. Capsule enteroscopy vs. other diagnostic procedures in diagnosing obscure gastrointestinal bleeding: a cost-effectiveness study. Eur J Gastroenterol Hepatol. 2007;19(7):535–42. https:\u002F\u002Fdoi.org\u002F10.1097\u002FMEG.0b013e32812144dd.\nSomsouk M, Gralnek IM, Inadomi JM. Management of obscure occult gastrointestinal bleeding: a cost-minimization analysis. Clin Gastroenterol Hepatol. 2008;6(6):661–70. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.cgh.2008.02.033.\nAlbert JG, Nachtigall F, Wiedbrauck F, Dollinger MM, Gittinger FS, Hollerbach S, et al. Minimizing procedural cost in diagnosing small bowel bleeding: comparison of a strategy based on initial capsule endoscopy versus initial double-balloon enteroscopy. Eur J Gastroenterol Hepatol. 2010;22(6):679–88.\nPalimaka S, Blackhouse G, Goeree R. Capsule endoscopy in the assessment of obscure gastrointestinal bleeding: an economic analysis. Ont Health Technol Assess Ser. 2015;15(2):1–32.\nJackson CS, Gerson LB. Management of gastrointestinal angiodysplastic lesions (GIADs): a systematic review and meta-analysis. Am J Gastroenterol. 2014;109(4):474–83; quiz 484. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fajg.2014.19.\nSakai E, Endo H, Taguri M, Kawamura H, Taniguchi L, Hata Y, et al. Frequency and risk factors for rebleeding events in patients with small bowel angioectasia. BMC Gastroenterol. 2014;14:200. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12876-014-0200-3.\nPinho R, Ponte A, Rodrigues A, Pinto-Pais T, Fernandes C, Ribeiro I, et al. Long-term rebleeding risk following endoscopic therapy of small-bowel vascular lesions with device-assisted enteroscopy. Eur J Gastroenterol Hepatol. 2016;28(4):479–85. https:\u002F\u002Fdoi.org\u002F10.1097\u002FMEG.0000000000000552.\nShinozaki S, Yamamoto H, Yano T, Sunada K, Hayashi Y, Shinhata H, et al. Favorable long-term outcomes of repeat endotherapy for small-intestine vascular lesions by double-balloon endoscopy. Gastrointest Endosc. 2014;80(1):112–7. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.gie.2013.11.029.\nRomagnuolo J, Brock AS, Ranney N. Is endoscopic therapy effective for angioectasia in obscure gastrointestinal bleeding?: a systematic review of the literature. J Clin Gastroenterol. 2015;49(10):823–30. https:\u002F\u002Fdoi.org\u002F10.1097\u002FMCG.0000000000000266.\nBauditz J. Effective treatment of gastrointestinal bleeding with thalidomide—chances and limitations. World J Gastroenterol. 2016;22(11):3158–64. https:\u002F\u002Fdoi.org\u002F10.3748\u002Fwjg.v22.i11.3158.\n• Chen H, Fu S, Feng N, Chen H, Gao Y, Zhao Y, et al. Bleeding recurrence in patients with gastrointestinal vascular malformation after thalidomide. Medicine (Baltimore). 2016;95(33):e4606. https:\u002F\u002Fdoi.org\u002F10.1097\u002FMD.0000000000004606. This retrospective study showed the efficacy of Thalidomide as treatment of GI angioectasia. An 80% response rate and 20% recurrence rate were found, confirming its relevance in patients at risk of vascular malformations. However, in 60% of patients, adverse events were observed.\nNardone G, Compare D, Scarpignato C, Rocco A. Long acting release-octreotide as “rescue” therapy to control angiodysplasia bleeding: a retrospective study of 98 cases. Digest Liver Dis. 2014;46(8):688–94. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.dld.2014.04.011.\n• Holleran G, Hall B, Breslin N, McNamara D. Long-acting somatostatin analogues provide significant beneficial effect in patients with refractory small bowel angiodysplasia: results from a proof of concept open label mono-centre trial. United European Gastroenterol J. 2016;4(1):70–6. https:\u002F\u002Fdoi.org\u002F10.1177\u002F2050640614559121. In this small study of 20 patients with small bowel angioectasia, long-acting somatostatin analogues proved to be effective in 90% of patients, significantly increasing hemoglobin values and reducing further transfusion need. However, adverse events were present in ~ 30%.\nGrooteman KV, van Geenen EJ, Drenth JP. Multicentre, open-label, randomised, parallel-group, superiority study to compare the efficacy of octreotide therapy 40 mg monthly versus standard of care in patients with refractory anaemia due to gastrointestinal bleeding from small bowel angiodysplasias: a protocol of the OCEAN trial. BMJ Open. 2016;6(9):e011442. https:\u002F\u002Fdoi.org\u002F10.1136\u002Fbmjopen-2016-011442.\nHongsakul K, Pakdeejit S, Tanutit P. Outcome and predictive factors of successful transarterial embolization for the treatment of acute gastrointestinal hemorrhage. Acta Radiol. 2014;55(2):186–94. https:\u002F\u002Fdoi.org\u002F10.1177\u002F0284185113494985.\nBua-Ngam C, Norasetsingh J, Treesit T, Wedsart B, Chansanti O, Tapaneeyakorn J, et al. Efficacy of emergency transarterial embolization in acute lower gastrointestinal bleeding: a single-center experience. Diagn Interv Imaging. 2017;98(6):499–505. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.diii.2017.02.005.\nManatsathit W, Khrucharoen U, Jensen DM, Hines OJ, Kovacs T, Ohning G, Jutabha R, Ghassemi K, Dulai GS, Machicado G. Laparotomy and intraoperative enteroscopy for obscure gastrointestinal bleeding before and after the era of video capsule endoscopy and deep enteroscopy: a tertiary center experience. Am J Surg. 2017. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.amjsurg.2017.05.018\nFrydman J, Bahouth H, Leiderman M, Ofer A, Kluger Y. Methylene Blue injection via superior mesenteric artery microcatheter for focused enterectomy in the treatment of a bleeding small intestinal arteriovenous malformation. World J Emerg Surg. 2014;9(1):17. https:\u002F\u002Fdoi.org\u002F10.1186\u002F1749-7922-9-17.\nTziatzios G, Gkolfakis P, Dimitriadis GD, Triantafyllou K. Long-term effects of video capsule endoscopy in the management of obscure gastrointestinal bleeding. Ann Transl Med. 2017;5(9):196. https:\u002F\u002Fdoi.org\u002F10.21037\u002Fatm.2017.03.80.\nHindryckx P, Botelberge T, De Vos M, De Looze D. Clinical impact of capsule endoscopy on further strategy and long-term clinical outcome in patients with obscure bleeding. Gastrointest Endosc. 2008;68(1):98–104. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.gie.2007.09.042.\n•• Niikura R, Yamada A, Nagata N, Kobayashi Y, Okamoto M, Mitsuno Y, et al. New predictive model of rebleeding during follow-up of patents with obscure gastrointestinal bleeding: a multicenter cohort study. J Gastroenterol Hepatol. 2016;31(4):752–60. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fjgh.13201. This study provides the reader with an interesting prognostic model, which is not only able to predict rebleeding, but also future transfusion needs, length of hospital stay, and mortality rates, based on the presence of 5 risk factors: female gender, liver cirrhosis, warfarin use, overt bleeding, and positive capsule endoscopy findings.\nRahmi G, Samaha E, Vahedi K, Delvaux M, Gay G, Lamouliatte H, et al. Long-term follow-up of patients undergoing capsule and double-balloon enteroscopy for identification and treatment of small-bowel vascular lesions: a prospective, multicenter study. Endoscopy. 2014;46(7):591–7. https:\u002F\u002Fdoi.org\u002F10.1055\u002Fs-0034-1365514.\nRibeiro I, Pinho R, Rodrigues A, Silva J, Ponte A, Rodrigues J, et al. What is the long-term outcome of a negative capsule endoscopy in patients with obscure gastrointestinal bleeding? Rev Esp Enferm Dig. 2015;107(12):753–8.\nTan W, Ge ZZ, Gao YJ, Li XB, Dai J, Fu SW, et al. Long-term outcome in patients with obscure gastrointestinal bleeding after capsule endoscopy. J Dig Dis. 2015;16(3):125–34. https:\u002F\u002Fdoi.org\u002F10.1111\u002F1751-2980.12222.\nMin YW, Kim JS, Jeon SW, Jeen YT, Im JP, Cheung DY, et al. Long-term outcome of capsule endoscopy in obscure gastrointestinal bleeding: a nationwide analysis. Endoscopy. 2014;46(1):59–65. https:\u002F\u002Fdoi.org\u002F10.1055\u002Fs-0033-1358803.\nOrmeci A, Akyuz F, Baran B, Gokturk S, Ormeci T, Pinarbasi B, et al. What is the impact of capsule endoscopy in the long term period? World J Gastrointest Endosc. 2016;8(7):344–8. https:\u002F\u002Fdoi.org\u002F10.4253\u002Fwjge.v8.i7.344.\nMatsumura T, Arai M, Saito K, Okimoto K, Saito M, Minemura S, Oyamada A, Maruoka D, Nakagawa T, Watabe H, Katsuno T, Yokosuka O. Predictive factor of re-bleeding after negative capsule endoscopy for obscure gastrointestinal bleeding: over 1-year follow-up study. Digest Endosc. 2014. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fden.12257\nMai SH, Chao DC, Liao SY, Jackson CS. Nonisolated small bowel gastrointestinal angiodysplasias are associated with higher rebleeding rates when compared with isolated small bowel gastrointestinal angiodysplasia on video capsule endoscopy. J Clin Gastroenterol. 2017; https:\u002F\u002Fdoi.org\u002F10.1097\u002FMCG.0000000000000836.\nShinozaki S, Yano T, Sakamoto H, Sunada K, Hayashi Y, Sato H, et al. Long-term outcomes in patients with overt obscure gastrointestinal bleeding after negative double-balloon endoscopy. Dig Dis Sci. 2015;60(12):3691–6. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs10620-015-3792-8.\n•• Yung DE, Koulaouzidis A, Avni T, Kopylov U, Giannakou A, Rondonotti E, et al. Clinical outcomes of negative small-bowel capsule endoscopy for small-bowel bleeding: a systematic review and meta-analysis. Gastrointest Endosc. 2017;85(2):305–317 e302. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.gie.2016.08.027. This large systematic review and meta-analysis showed that negative capsule endoscopies were associated with low rebleeding rates. However, this protective effect was only observed for a period of 2 years.",{"VOID":1698},"10.1007\u002Fs11894-018-0610-4","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs11894-018-0610-4",[1701,1716,1729,1744],{"id":1702,"sortIndex":32,"researcher":28,"roles":1703,"affiliations":1704,"properties":1713,"displayName":1715,"givenName":28,"familyName":28},"54e95926-d6a9-4132-bdff-d6f3b03fcfdc",[950],[1705],{"id":1706,"sortIndex":32,"affiliation":1707,"properties":28},"be51bb94-a294-41a6-bde5-2fbd3328e4e9",{"id":1706,"createTime":28,"updateTime":28,"relativeEntities":1708,"slug":28,"properties":1709,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1712,"statistic":28},[],{"title":1710},{"VI":1711},"Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium",[],{"title":1714},{"VI":1715},"Cedric Van de Bruaene",{"id":1717,"sortIndex":40,"researcher":28,"roles":1718,"affiliations":1719,"properties":1726,"displayName":1728,"givenName":28,"familyName":28},"d9823d58-2919-4c39-acc0-1d8170136c74",[950],[1720],{"id":1706,"sortIndex":32,"affiliation":1721,"properties":28},{"id":1706,"createTime":28,"updateTime":28,"relativeEntities":1722,"slug":28,"properties":1723,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1725,"statistic":28},[],{"title":1724},{"VI":1711},[],{"title":1727},{"VI":1728},"Pieter Hindryckx",{"id":1730,"sortIndex":123,"researcher":28,"roles":1731,"affiliations":1732,"properties":1741,"displayName":1743,"givenName":28,"familyName":28},"c56ed4e2-91e6-47db-9a44-a8d761d0181b",[950],[1733],{"id":1734,"sortIndex":32,"affiliation":1735,"properties":28},"45e11e69-18c9-4c02-ae12-dfcf6294b90b",{"id":1734,"createTime":28,"updateTime":28,"relativeEntities":1736,"slug":28,"properties":1737,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1740,"statistic":28},[],{"title":1738},{"VI":1739},"Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium",[],{"title":1742},{"VI":1743},"Laurens Van de Bruaene",{"id":1745,"sortIndex":42,"researcher":28,"roles":1746,"affiliations":1747,"properties":1754,"displayName":1756,"givenName":28,"familyName":28},"abf84bb9-88ba-4953-9264-94569639d4e5",[950],[1748],{"id":1706,"sortIndex":32,"affiliation":1749,"properties":28},{"id":1706,"createTime":28,"updateTime":28,"relativeEntities":1750,"slug":28,"properties":1751,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1753,"statistic":28},[],{"title":1752},{"VI":1711},[],{"title":1755},{"VI":1756},"Danny De Looze",{"url":1699,"publisher":1758,"properties":1792},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1759,"slug":872,"properties":1760,"entityType":25,"verifyStatus":882,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1764,"manageAffiliations":1773,"indexDatabases":1779,"url":28,"thumbnailPath":28,"statistic":1787,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1761,"title":1762,"eissn":1763},{"VOID":877},{"EN":879},{"VOID":875},[1765,1769],{"id":885,"createTime":28,"updateTime":28,"relativeEntities":1766,"label":1767,"description":1768,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":888},{},{"id":891,"createTime":28,"updateTime":28,"relativeEntities":1770,"label":1771,"description":1772,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":894},{},[1774],{"id":898,"createTime":28,"updateTime":28,"relativeEntities":1775,"slug":28,"properties":1776,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1778,"statistic":28},[],{"title":1777},{"EN":902},[],[1780],{"id":906,"indexDatabase":1781,"url":912,"indexYears":913,"academicFieldIds":1786,"indexDatabaseRanking":917},{"id":786,"createTime":28,"updateTime":28,"relativeEntities":1782,"label":1783,"description":1784,"key":792,"publicationTags":1785,"standard":28},[],{"EN":789,"VI":789},{"EN":789,"VI":791},[794],[915,916],{"impactFactor":32,"impactFactorByYear":1788,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":920,"totalPublicationByYear":1789,"totalCitation":32,"totalCitationByYear":1790,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":1791,"hindexLast5Year":32,"hindex":32},{},{"1996":40,"1999":196,"2000":139,"2001":142,"2002":150,"2003":200,"2004":280,"2005":152,"2006":352,"2007":150,"2008":208,"2009":139,"2010":279,"2011":132,"2012":278,"2013":139,"2014":147,"2015":136,"2016":352,"2017":148,"2018":132,"2019":147,"2020":69,"2021":146,"2022":51,"2023":142,"2024":45},{},{},{"pages":1793,"volume":1795},{"VOID":1794},"1-12",{"VOID":1796},"20","2018-03-07",2018,[917],{"id":1801,"createTime":1802,"updateTime":1802,"relativeEntities":1803,"slug":28,"properties":1804,"entityType":943,"verifyStatus":882,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1813,"fullTextUrl":28,"authors":1814,"publicationType":984,"publisherRelationship":1887,"citationCount":28,"citationInfo":28,"publishDate":1927,"publishYear":1928,"citationAnalyzeStatus":882,"lastCitationAnalyze":28,"indexDatabases":1929,"openAccess":28,"references":28,"isForceReanalyzing":1028},"0218a137-f444-49d5-bdd1-9824a911040e","2024-02-14T15:00:43.555+00:00",[],{"abstract":1805,"title":1807,"references":1809,"doi":1811},{"EN":1806},"C-terminally amidated gastrins act at cholecystokinin-2 receptors (CCK2R), which are normally expressed by gastric parietal and enterochromaffin-like (ECL) cells and smooth muscle; there is also extensive expression in the CNS where the main endogenous ligand is cholecystokinin. A variety of neoplasms express CCK2R, or splice variants, including neuroendocrine, pancreatic, medullary thyroid and lung cancers. Other products of the gastrin gene (progastrin, the Gly-gastrins) may stimulate cell proliferation but are not CCK2R ligands. Depending on the cell type, stimulation of CCK2R evokes secretion, increases proliferation and cell migration, inhibits apoptosis, and controls the expression of various genes. These effects are mediated by increased intracellular calcium and activation of protein kinase C, MAPkinase and other protein kinase cascades. There has been recent progress in developing CCK2R ligands that can be used for imaging tumours expressing the receptor. New antagonists have also been developed, and there is scope for using these for suppression of gastric acid and for treatment of neuroendocrine and other CCK2R-expressing tumours.",{"EN":1808},"Gastrin Receptor Pharmacology",{"VOID":1810},"Morton M, Prendergast C, Barrett TD. Targeting gastrin for the treatment of gastric acid related disorders and pancreatic cancer. Trends Pharmacol Sci. 2011;32:201–5.\nChao C, Hellmich MR. Gastrin, inflammation, and carcinogenesis. Curr Opin Endocrinol Diabetes Obes. 2010;17:33–9.\nBurkitt MD, Varro A, Pritchard DM. Importance of gastrin in the pathogenesis and treatment of gastric tumors. World J Gastroenterol. 2009;15:1–16.\nKopin AS, Lee YM, McBride EW, et al. Expression cloning and characterization of the canine parietal cell gastrin receptor. Proc Natl Acad Sci USA. 1992;89:3605–9.\nHellmich MR, Rui XL, Hellmich HL, et al. Human colorectal cancers express a constitutively active cholecystokinin-B\u002Fgastrin receptor that stimulates cell growth. J Biol Chem. 2000;275:32122–8.\nKorner M, Waser B, Reubi JC, Miller LJ. CCK(2) receptor splice variant with intron 4 retention in human gastrointestinal and lung tumours. J Cell Mol Med. 2010;14:933–43.\nRyberg A, Borch K, Monstein HJ. Expression of multiple forms of 3'-end variant CCK2 receptor mRNAs in human pancreatic adenocarcinomas. BMC Res Notes. 2011;4:131.\nSmith JP, Harms JF, Matters GL, et al. A single nucleotide polymorphism of the cholecystokinin-B receptor predicts risk for pancreatic cancer. Cancer Biol Ther. 2012;13:164–74.\nSanchez C, Escrieut C, Clerc P, et al. Characterization of a novel five-transmembrane domain cholecystokinin-2 receptor splice variant identified in human tumors. Mol Cell Endocrinol. 2012;349:170–9.\nKan Z, Jaiswal BS, Stinson J, et al. Diverse somatic mutation patterns and pathway alterations in human cancers. Nature. 2010;466:869–73.\nWillard MD, Lajiness ME, Wulur IH, et al. Somatic mutations in CCK2R alter receptor activity that promote oncogenic phenotypes. Mol Cancer Res. 2012 in press.\nSong Y, Xu Y, Wang Z, et al. MicroRNA-148b suppresses cell growth by targeting cholecystokinin-2 receptor in colorectal cancer. Int J Cancer. 2011. doi:10.1002\u002Fijc.26485.\nSong YX, Yue ZY, Wang ZN, et al. MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation. Mol Cancer. 2011;10:1.\nPatel O, Marshall KM, Bramante G, et al. The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway. Regul Pept. 2010;165:224–31.\nFourmy D, Gigoux V, Reubi JC. Gastrin in gastrointestinal diseases. Gastroenterology. 2011;141:814–8. e811-813.\n• Jin G, Ramanathan V, Quante M, et al. Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice. J Clin Invest. 2009;119:2691–701. In transgenic mice overexpressing progastrin there is stimulation of colonic epithelial cell proliferation, colon cryptic fission and promotion of colorectal cancer; progastrin is not a CCK2R ligand. However, by using CCK2R null mice crossed with mice over-expressing progastrin, this study demonstrates that CCK2R is required for the action of progastrin.\n• Sarkar S, Swiercz R, Kantara C, et al. Annexin A2 mediates up-regulation of NF-kappaB, beta-catenin, and stem cell in response to progastrin in mice and HEK-293 cells. Gastroenterology. 2011;140:583–95 e584. AnnexinA2 has been proposed as a receptor for progastrin. This paper reports that annexin A2 is required for the action of progastrin on colon cancer cells in vitro and on colon epithelial cells in vivo; p65 NFκB and β-catenin are required for the proliferative actions of progastrin.\nSarkar S, Kantara C, Singh P. Clathrin mediates endocytosis of progastrin and activates MAPKs: role of cell surface annexin A2. Am J Physiol Gastrointest Liver Physiol. 2012;302:G712–22.\nKovac S, Xiao L, Shulkes A, et al. Gastrin increases its own synthesis in gastrointestinal cancer cells via the CCK2 receptor. FEBS Lett. 2010;584:4413–8.\nFerrand A, Lachal S, Bramante G, et al. Stimulation of proliferation in the colorectal mucosa by gastrin precursors is blocked by desferrioxamine. Am J Physiol Gastrointest Liver Physiol. 2010;299:G220–7.\nKowalski-Chauvel A, Najib S, Bertrand C, et al. Cell surface F1-ATPase binds the gastrin precursor, G-gly, and mediates its proliferative effects on colorectal cancer cells and vascular endothelial cells. Regul Pept. 2010;164:48.\nDufresne M, Seva C, Fourmy D. Cholecystokinin and gastrin receptors. Physiol Rev. 2006;86:805–47.\nPaillasse MR, de Medina P, Amouroux G, et al. Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion. J Lipid Res. 2009;50:2203–11.\nLanger I, Tikhonova IG, Boulegue C, et al. Evidence for a direct and functional interaction between the regulators of G protein signaling-2 and phosphorylated C terminus of cholecystokinin-2 receptor. Mol Pharmacol. 2009;75:502–13.\nMagnan R, Masri B, Escrieut C, et al. Regulation of membrane cholecystokinin-2 receptor by agonists enables classification of partial agonists as biased agonists. J Biol Chem. 2011;286:6707–19.\nDockray GJ. Gastrin. Best Pract Res Clin Endocrinol Metab. 2004;18:555–68.\nWang TC, Dangler CA, Chen D, et al. Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology. 2000;118:36–47.\nFjeldbo CS, Bakke I, Erlandsen SE, et al. Gastrin upregulates the prosurvival factor secretory clusterin in adenocarcinoma cells and in oxyntic mucosa of hypergastrinemic rats. Am J Physiol Gastrointest Liver Physiol. 2012;302:G21–33.\nNorsett KG, Steele I, Duval C, et al. Gastrin stimulates expression of plasminogen activator inhibitor-1 in gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2011;301:G446–53.\nMishra P, Senthivinayagam S, Rana A, Rana B. Glycogen Synthase Kinase-3beta regulates Snail and beta-catenin during gastrin-induced migration of gastric cancer cells. J Mol Signal. 2010;5:9.\nMishra P, Senthivinayagam S, Rangasamy V, et al. Mixed lineage kinase-3\u002FJNK1 axis promotes migration of human gastric cancer cells following gastrin stimulation. Mol Endocrinol. 2010;24:598–607.\nZhou JJ, Chen ML, Zhang QZ, et al. Blocking gastrin and CCK-B autocrine loop affects cell proliferation and apoptosis in vitro. Mol Cell Biochem. 2010;343:133–41.\nBerna MJ, Seiz O, Nast JF, et al. CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production. J Biol Chem. 2010;285:38905–14.\nKato H, Seto K, Kobayashi N, et al. CCK-2\u002Fgastrin receptor signaling pathway is significant for gemcitabine-induced gene expression of VEGF in pancreatic carcinoma cells. Life Sci. 2011;89:603–8.\nFino KK, Matters GL, McGovern CO, et al. Down-regulation of the CCK-B receptor in pancreatic cancer cells blocks proliferation and promotes apoptosis. Am J Physiol Gastrointest Liver Physiol. 2012 in press.\nCayrol C, Bertrand C, Kowalski-Chauvel A, et al. alphav integrin: a new gastrin target in human pancreatic cancer cells. World J Gastroenterol. 2011;17:4488–95.\nChao C, Han X, Ives K, et al. CCK2 receptor expression transforms non-tumorigenic human NCM356 colonic epithelial cells into tumor forming cells. Int J Cancer. 2010;126:864–75.\nBerna MJ, Tapia JA, Sancho V, Jensen RT. Progress in developing cholecystokinin (CCK)\u002Fgastrin receptor ligands that have therapeutic potential. Curr Opin Pharmacol. 2007;7:583–92.\nGupta AK, Varshney K, Saxena AK. Toward the Identification of a Reliable 3D QSAR Pharmacophore Model for the CCK2 Receptor Antagonism. J Chem Inf Model. 2012 in press.\nCawston EE, Lam PC, Harikumar KG, et al. Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor. J Biol Chem. 2012 in press.\n• Morton MF, Barrett TD, Freedman J, et al. JNJ-26070109 [(R)4-bromo-N-[1-(2,4-difluoro-phenyl)-ethyl]-2-(quinoxaline-5-sulfonylamino)-ben zamide]: a novel, potent, and selective cholecystokinin 2 receptor antagonist with good oral bioavailability. J Pharmacol Exp Ther. 2011;338:328–36. A new class of CCK2R antagonist is described. JNJ-26070109 has high oral bioavailability, and exhibits high affinity and selectivity for CCK2R. It inhibits acid secretion in several different models and is a suitable candidate for further evaluation as an anti-secretory agent.\nBarrett T, Lagaud G, Wagaman P, et al. The CCK(2) receptor antagonist, JNJ-26070109, inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rat. Br J Pharmacol. 2012 in press.\nSoll AH. The interaction of histamine with gastrin and carbamylcholine on oxygen uptake by isolated mammalian parietal cells. J Clin Invest. 1978;61:381–9.\nBlack JW, Shankley NP. How does gastrin act to stimulate oxyntic cell secretion. TIPS. 1987;8:486–90.\nRoberts K, Ursini A, Barnaby R, et al. Synthesis and structure-activity relationship of new 1,5-dialkyl-1,5-benzodiazepines as cholecystokinin-2 receptor antagonists. Bioorg Med Chem. 2011;19:4257–73.\n• Roosenburg S, Laverman P, van Delft FL, Boerman OC. Radiolabeled CCK\u002Fgastrin peptides for imaging and therapy of CCK2 receptor-expressing tumors. Amino Acids. 2011;41:1049–58. A valuable review of recent progress in developing labelled analogues for radionuclide imaging and therapy of CCK2R-expressing tumours.\nAloj L, Aurilio M, Rinaldi V, et al. Comparison of the binding and internalization properties of 12 DOTA-coupled and (1)(1)(1)In-labelled CCK2\u002Fgastrin receptor binding peptides: a collaborative project under COST Action BM0607. Eur J Nucl Med Mol Imaging. 2011;38:1417–25.\nLaverman P, Joosten L, Eek A, et al. Comparative biodistribution of 12 (1)(1)(1)In-labelled gastrin\u002FCCK2 receptor-targeting peptides. Eur J Nucl Med Mol Imaging. 2011;38:1410–6.\nvon Guggenberg E, Rangger C, Sosabowski J, et al. Preclinical evaluation of radiolabeled DOTA-derivatized cyclic minigastrin analogs for targeting cholecystokinin receptor expressing malignancies. Mol Imaging Biol. 2012;14:366–75.\nBrom M, Joosten L, Laverman P, et al. Preclinical evaluation of 68 Ga-DOTA-minigastrin for the detection of cholecystokinin-2\u002Fgastrin receptor-positive tumors. Mol Imaging. 2011;10:144–52.\nDorbes S, Mestre-Voegtle B, Coulais Y, et al. Synthesis, characterization and in vitro evaluation of new oxorhenium- and oxotechnetium-CCK4 derivatives as molecular imaging agents for CCK2-receptor targeting. Eur J Med Chem. 2010;45:423–9.\nAkgun E, Korner M, Gao F, et al. Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and type 2 cholecystokinin receptors. J Med Chem. 2009;52:2138–47.\nLaabs E, Behe M, Kossatz S, et al. Optical imaging of CCK\u002Fgastrin receptor-positive tumors with a minigastrin near-infrared probe. Invest Radiol. 2011;46:196–201.\nKumari S, Chowdhury J, Mishra AK, et al. Synthesis and evaluation of a fluorescent non-peptidic cholecystokinin-B\u002Fgastrin receptor specific antagonist for cancer cell imaging. Chembiochem. 2012;13:282–92.\nGilliam AD, Broome P, Topuzov EG, et al. An international multicenter randomized controlled trial of G17DT in patients with pancreatic cancer. Pancreas. 2012;41:374–9.\nTieppo C, Betterle C, Basso D, et al. Gastric type I carcinoid: a pilot study with human G17DT immunogen vaccination. Cancer Immunol Immunother. 2011;60:1057–60.\n• Boyce M, David O, Darwin K, et al. Single oral doses of netazepide (YF476), a gastrin receptor antagonist, cause dose-dependent, sustained increases in gastric pH compared with placebo and ranitidine in healthy subjects. Aliment Pharmacol Ther. 2012. doi:10.1111\u002Fj.1365-2036.2012.05143.x. First in man study of the effect of netazepide on gastric pH. The compound is orally active and well tolerated. At 25 mg it was superior to 150 mg ranitidine in raising 24-h gastric pH. Future trials appear justified.\nHagiwara T, Mukaisho K, Nakayama T, et al. Long-term proton pump inhibitor administration worsens atrophic corpus gastritis and promotes adenocarcinoma development in Mongolian gerbils infected with Helicobacter pylori. Gut. 2011;60:624–30.\nHassall E, Owen D, Kerr W, et al. Gastric histology in children treated with proton pump inhibitors long term, with emphasis on enterochromaffin cell-like hyperplasia. Aliment Pharmacol Ther. 2011;33:829–36.\nPoulsen AH, Christensen S, McLaughlin JK, et al. Proton pump inhibitors and risk of gastric cancer: a population-based cohort study. Br J Cancer. 2009;100:1503–7.\nBradley MC, Murray LJ, Cantwell MM, Hughes CM. Proton pump inhibitors and histamine-2-receptor antagonists and pancreatic cancer risk: a nested case–control study. Br J Cancer. 2012;106:233–9.\nKidd M, Siddique ZL, Drozdov I, et al. The CCK(2) receptor antagonist, YF476, inhibits Mastomys ECL cell hyperplasia and gastric carcinoid tumor development. Regul Pept. 2010;162:52–60.\n• Meyer T, Caplin ME, Palmer DH, et al. A phase Ib\u002FIIa trial to evaluate the CCK2 receptor antagonist Z-360 in combination with gemcitabine in patients with advanced pancreatic cancer. Eur J Cancer. 2010;46:526–33. The CCK2R antagonist Z-360 was studied in a trial of 33 patients with pancreatic cancer receiving Z-360 with gemcitabine compared with gemcitabine alone. Z-360 was safe and well tolerated and the data indicate that a phase III trial is now justified to determine whether Z-360 together with gemcitabine offers additional advantages over gemcitabine alone.\nOrikawa Y, Kato H, Seto K, et al. Z-360, a novel therapeutic agent for pancreatic cancer, prevents up-regulation of ephrin B1 gene expression and phosphorylation of NR2B via suppression of interleukin-1 beta production in a cancer-induced pain model in mice. Mol Pain. 2010;6:72.\nYoshinaga K, Horii T, Hamano H, et al. Pharmacological evaluation of analgesic effects of the cholecystokinin2 receptor antagonist Z-360 in mouse models of formalin- and cancer-induced pain. Biol Pharm Bull. 2010;33:244–8.",{"VOID":1812},"10.1007\u002Fs11894-012-0293-1","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs11894-012-0293-1",[1815,1839,1861,1874],{"id":1816,"sortIndex":32,"researcher":28,"roles":1817,"affiliations":1818,"properties":1836,"displayName":1838,"givenName":28,"familyName":28},"70465297-1a8f-488e-8b90-65cdc76f37a6",[950],[1819,1827],{"id":1820,"sortIndex":32,"affiliation":1821,"properties":28},"9885f489-26c3-42b8-9f7b-d9b24f3c3cb7",{"id":1820,"createTime":28,"updateTime":28,"relativeEntities":1822,"slug":28,"properties":1823,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1826,"statistic":28},[],{"title":1824},{"VI":1825},"Departments of Cell and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK",[],{"id":1828,"sortIndex":40,"affiliation":1829,"properties":1835},"313bb5cd-acf7-4fc3-8136-b5648920264e",{"id":1828,"createTime":28,"updateTime":28,"relativeEntities":1830,"slug":28,"properties":1831,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1834,"statistic":28},[],{"title":1832},{"VI":1833},"Physiological Laboratory, Institute of Translational Medicine, University of Liverpool, Liverpool, UK",[],{},{"title":1837},{"VI":1838},"Graham J. Dockray",{"id":1840,"sortIndex":40,"researcher":28,"roles":1841,"affiliations":1842,"properties":1858,"displayName":1860,"givenName":28,"familyName":28},"f4129428-4aca-434e-b342-3147618bcd28",[950],[1843,1849],{"id":1820,"sortIndex":32,"affiliation":1844,"properties":28},{"id":1820,"createTime":28,"updateTime":28,"relativeEntities":1845,"slug":28,"properties":1846,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1848,"statistic":28},[],{"title":1847},{"VI":1825},[],{"id":1850,"sortIndex":40,"affiliation":1851,"properties":1857},"f46152d1-6d7d-44e6-8cc0-e952de842e0c",{"id":1850,"createTime":28,"updateTime":28,"relativeEntities":1852,"slug":28,"properties":1853,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1856,"statistic":28},[],{"title":1854},{"VI":1855},"Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK",[],{},{"title":1859},{"VI":1860},"Andy Moore",{"id":1862,"sortIndex":123,"researcher":28,"roles":1863,"affiliations":1864,"properties":1871,"displayName":1873,"givenName":28,"familyName":28},"ee619f92-2c52-4e2a-9aa5-2744cb1ac346",[950],[1865],{"id":1820,"sortIndex":32,"affiliation":1866,"properties":28},{"id":1820,"createTime":28,"updateTime":28,"relativeEntities":1867,"slug":28,"properties":1868,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1870,"statistic":28},[],{"title":1869},{"VI":1825},[],{"title":1872},{"VI":1873},"Andrea Varro",{"id":1875,"sortIndex":42,"researcher":28,"roles":1876,"affiliations":1877,"properties":1884,"displayName":1886,"givenName":28,"familyName":28},"6cdc0319-c1db-4c41-9f9e-f73cda2d5c00",[950],[1878],{"id":1850,"sortIndex":32,"affiliation":1879,"properties":28},{"id":1850,"createTime":28,"updateTime":28,"relativeEntities":1880,"slug":28,"properties":1881,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1883,"statistic":28},[],{"title":1882},{"VI":1855},[],{"title":1885},{"VI":1886},"D. Mark Pritchard",{"url":1813,"publisher":1888,"properties":1922},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1889,"slug":872,"properties":1890,"entityType":25,"verifyStatus":882,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1894,"manageAffiliations":1903,"indexDatabases":1909,"url":28,"thumbnailPath":28,"statistic":1917,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1891,"title":1892,"eissn":1893},{"VOID":877},{"EN":879},{"VOID":875},[1895,1899],{"id":885,"createTime":28,"updateTime":28,"relativeEntities":1896,"label":1897,"description":1898,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":888},{},{"id":891,"createTime":28,"updateTime":28,"relativeEntities":1900,"label":1901,"description":1902,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":894},{},[1904],{"id":898,"createTime":28,"updateTime":28,"relativeEntities":1905,"slug":28,"properties":1906,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1908,"statistic":28},[],{"title":1907},{"EN":902},[],[1910],{"id":906,"indexDatabase":1911,"url":912,"indexYears":913,"academicFieldIds":1916,"indexDatabaseRanking":917},{"id":786,"createTime":28,"updateTime":28,"relativeEntities":1912,"label":1913,"description":1914,"key":792,"publicationTags":1915,"standard":28},[],{"EN":789,"VI":789},{"EN":789,"VI":791},[794],[915,916],{"impactFactor":32,"impactFactorByYear":1918,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":920,"totalPublicationByYear":1919,"totalCitation":32,"totalCitationByYear":1920,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":1921,"hindexLast5Year":32,"hindex":32},{},{"1996":40,"1999":196,"2000":139,"2001":142,"2002":150,"2003":200,"2004":280,"2005":152,"2006":352,"2007":150,"2008":208,"2009":139,"2010":279,"2011":132,"2012":278,"2013":139,"2014":147,"2015":136,"2016":352,"2017":148,"2018":132,"2019":147,"2020":69,"2021":146,"2022":51,"2023":142,"2024":45},{},{},{"pages":1923,"volume":1925},{"VOID":1924},"453-459",{"VOID":1926},"14","2012-09-16",2012,[917]]