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381",{},false,{"id":449,"createTime":450,"updateTime":450,"relativeEntities":451,"slug":452,"properties":453,"entityType":130,"verifyStatus":467,"verifyTime":450,"verifyNote":468,"syncStatus":23,"languages":469,"translateLanguages":24,"viewCount":25,"primaryUrl":470,"fullTextUrl":24,"authors":471,"publicationType":236,"publisherRelationship":509,"citationCount":542,"citationInfo":543,"publishDate":550,"publishYear":551,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":552,"isForceReanalyzing":447},"f7885e4c-0f73-46b9-83ac-9f3f7db779ac","2024-08-30T23:17:11.774+00:00",[],"Cyclooxygenase-2-its-regulation-role-and-impact-in-airway-inflammation",{"mag":454,"keywords":456,"openalex":457,"abstract":459,"title":461,"pm":463,"doi":465},{"VOID":455},"2288465238",{},{"VOID":458},"W2288465238",{"EN":460},"\u003Cjats:title>Summary\u003C\u002Fjats:title>\u003Cjats:p>Cyclooxygenase 2 (COX‐2: official gene symbol – PTGS2) has long been regarded as playing a pivotal role in the pathogenesis of airway inflammation in respiratory diseases including asthma. COX‐2 can be rapidly and robustly expressed in response to a diverse range of pro‐inflammatory cytokines and mediators. Thus, increased levels of COX‐2 protein and prostanoid metabolites serve as key contributors to pathobiology in respiratory diseases typified by dysregulated inflammation. But COX‐2 products may not be all bad: prostanoids can exert anti‐inflammatory\u002Fbronchoprotective functions in airways in addition to their pro‐inflammatory actions. Herein, we outline COX‐2 regulation and review the diverse stimuli known to induce COX‐2 in the context of airway inflammation. We discuss some of the positive and negative effects that COX‐2\u002Fprostanoids can exert in \u003Cjats:italic>in vitro\u003C\u002Fjats:italic> and \u003Cjats:italic>in vivo\u003C\u002Fjats:italic> models of airway inflammation, and suggest that inhibiting COX‐2 expression to repress airway inflammation may be too blunt an approach; because although it might reduce the unwanted effects of COX‐2 activation, it may also negate the positive effects. Evidence suggests that prostanoids produced via COX‐2 upregulation show diverse actions (and herein we focus on prostaglandin E\u003Cjats:sub>2\u003C\u002Fjats:sub> as a key example); these can be either beneficial or deleterious and their impact on respiratory disease can be dictated by local concentration and specific interaction with individual receptors. We propose that understanding the regulation of COX‐2 expression and associated receptor‐mediated functional outcomes may reveal number of critical steps amenable to pharmacological intervention. These may prove invaluable in our quest towards future development of novel anti‐inflammatory pharmacotherapeutic strategies for the treatment of airway diseases.\u003C\u002Fjats:p>",{"EN":462},"Cyclooxygenase 2: its regulation, role and impact in airway inflammation",{"VOID":464},"26685098",{"VOID":466},"10.1111\u002Fcea.12697","VERIFIED","Auto Verify",[134],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fcea.12697",[472,492],{"id":473,"sortIndex":25,"researcher":24,"roles":474,"affiliations":475,"properties":487},"1c52a49d-1932-477b-bef3-04c23a0a04d4",[],[476],{"id":477,"sortIndex":25,"affiliation":478,"properties":24},"fc55475f-364c-4a4b-aa11-f6d0e66295ec",{"id":479,"createTime":480,"updateTime":481,"relativeEntities":482,"slug":483,"properties":484,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"1ab3e006-c90a-4462-ae74-ed44a93f0b43","2023-12-22T04:34:11.159+00:00","2024-08-30T23:17:11.787+00:00",[],"Faculty-of-Pharmacy-University-of-Sydney-Sydney-NSW-Australia",{"title":485},{"VI":486},"Faculty of Pharmacy, University of Sydney, Sydney NSW, Australia",{"openalex":488,"title":490},{"VOID":489},"A5071789365",{"EN":491},"Nowshin N. 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A number of allergenic proteins in peanut has been described and the relative importance of these allergens is yet to be determined.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Objectives\n\t\t\t\t\t\u003C\u002Fjats:bold> We have investigated the relevance of previously identified peanut allergens in well‐characterized peanut‐allergic patients by \u003Cjats:italic>in vitro\u003C\u002Fjats:italic>, \u003Cjats:italic>ex vivo\u003C\u002Fjats:italic> and \u003Cjats:italic>in vivo\u003C\u002Fjats:italic> assays.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Methods\n\t\t\t\t\t\u003C\u002Fjats:bold> Thirty‐two adult peanut‐allergic patients were included based on careful and standardized patient history and the presence of peanut‐specific IgE. The diagnosis peanut allergy was confirmed using double‐blind placebo‐controlled food challenges in 23 patients. Major peanut allergens Ara h1, Ara h2 and Ara h3 were purified from peanuts using ion‐exchange chromatography. IgE immunoblotting was performed and IgE‐cross‐linking capacity was examined by measuring histamine release (HR) after incubating patient basophils as well as passively sensitized basophils with several dilutions of the allergens. Intracutaneous tests (ICTs) using 10‐fold dilution steps of the purified allergens and crude peanut extract were performed.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Results\n\t\t\t\t\t\u003C\u002Fjats:bold> Ara h2 was recognized most frequently (26 out of 32) in all tests and induced both positive skin tests and basophil degranulation at low concentrations, whereas Ara h1 and Ara h3 were recognized less frequently and reacted only at 100‐fold higher concentrations as analysed with HR and intracutaneous testing (ICT). Next to the three tested allergens, proteins with molecular weights of somewhat smaller than 15 kDa were identified as a IgE‐binding proteins on immunoblot in the majority of the patients (20 out of 32).\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Conclusion\n\t\t\t\t\t\u003C\u002Fjats:bold> We conclude that Ara h2 is, for our patient group, the most important peanut allergen, and that previously unidentified peanut proteins with molecular weights of somewhat smaller than 15 kDa may be important allergens as well. ICT in combination with basophil–HR and IgE immunoblotting provides insight in the patient specificity towards the individual peanut allergens.\u003C\u002Fjats:p>",{"EN":1050},"Relevance of Ara h1, Ara h2 and Ara h3 in peanut‐allergic patients, as determined by immunoglobulin E Western blotting, basophil–histamine release and intracutaneous testing: Ara h2 is the most important peanut allergen",{"VOID":1052},"15080811",{"VOID":1054},"10.1111\u002Fj.1365-2222.2004.1923.x",[134],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1365-2222.2004.1923.x",[1058,1080,1108,1125,1140],{"id":1059,"sortIndex":215,"researcher":24,"roles":1060,"affiliations":1061,"properties":1073},"bcc75a7b-de0c-4070-b77c-a2a1b83b520a",[],[1062],{"id":1063,"sortIndex":25,"affiliation":1064,"properties":24},"d6cf8f1b-c988-492e-97ac-5178fd3d0f94",{"id":1065,"createTime":1066,"updateTime":1067,"relativeEntities":1068,"slug":1069,"properties":1070,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"2523c370-d7bc-48da-b824-6749fcbfa72e","2024-04-16T16:55:11.678+00:00","2024-09-24T22:21:13.531+00:00",[],"Department-of-Dermatology-Allergology-University-Hospital-Utrecht-Utrecht-The-Netherlands",{"title":1071},{"EN":1072},"Department of Dermatology\u002FAllergology, University Hospital Utrecht, Utrecht, The Netherlands",{"openalex":1074,"orcid":1076,"title":1078},{"VOID":1075},"A5069168470",{"VOID":1077},"https:\u002F\u002Forcid.org\u002F0000-0001-6569-8137",{"EN":1079},"Michel Wensing",{"id":1081,"sortIndex":25,"researcher":24,"roles":1082,"affiliations":1083,"properties":1101},"911b4e2c-dc7f-4a5a-bbc0-37b6f3490d26",[],[1084,1095],{"id":1085,"sortIndex":215,"affiliation":1086,"properties":24},"5ed4909c-83fe-4ced-b4d4-c9cc001ce2b8",{"id":1087,"createTime":1088,"updateTime":1089,"relativeEntities":1090,"slug":1091,"properties":1092,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"98dfe014-e210-42a9-8275-27faefcc4325","2023-12-20T00:59:56.498+00:00","2024-12-10T17:11:17.017+00:00",[],"TNO-Nutrition-and-Food-Research-Zeist-The-Netherlands",{"title":1093},{"VI":1094},"TNO Nutrition and Food Research, Zeist, The Netherlands",{"id":1096,"sortIndex":25,"affiliation":1097,"properties":24},"da38a431-6351-402c-8e78-48b3075cc95e",{"id":1065,"createTime":1066,"updateTime":1067,"relativeEntities":1098,"slug":1069,"properties":1099,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1100},{"EN":1072},{"openalex":1102,"orcid":1104,"title":1106},{"VOID":1103},"A5077307535",{"VOID":1105},"https:\u002F\u002Forcid.org\u002F0000-0001-7995-1754",{"EN":1107},"Stef J. 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I. Enhanced passive sensitization for histamine release, J Immunol, 131, 1949, 10.4049\u002Fjimmunol.131.4.1949",{"doi":1275},"10.4049\u002Fjimmunol.131.4.1949",{"id":24,"text":1277,"url":24,"identifiers":1278},"10.1016\u002FS0091-6749(98)70178-2",{"doi":1277},{"id":24,"text":1280,"url":24,"identifiers":1281},"10.1159\u002F000231384",{"doi":1280},{"id":24,"text":1283,"url":24,"identifiers":1284},"10.1002\u002Feji.1830210404",{"doi":1283},{"id":24,"text":1286,"url":24,"identifiers":1287},"10.1016\u002FS0091-6749(97)70245-8",{"doi":1286},{"id":24,"text":1289,"url":24,"identifiers":1290},"10.1046\u002Fj.1365-2222.1999.00521.x",{"doi":1289},{"id":24,"text":1292,"url":24,"identifiers":1293},"10.1034\u002Fj.1398-9995.2001.056002132.x",{"doi":1292},{"id":24,"text":1295,"url":24,"identifiers":1296},"10.4049\u002Fjimmunol.169.2.882",{"doi":1295},{"id":24,"text":1298,"url":24,"identifiers":1299},"10.1016\u002FS0091-6749(02)82053-X",{"doi":1298},{"id":24,"text":1301,"url":24,"identifiers":1302},"10.1067\u002Fmai.2003.61",{"doi":1301},{"id":24,"text":1304,"url":24,"identifiers":1305},"10.1111\u002Fj.1398-9995.1998.tb03967.x",{"doi":1304},{"id":24,"text":1307,"url":24,"identifiers":1308},"Crowe SE, 1992, Gastrointestinal food hypersensitivity, basic mechanisms of pathophysiology, 103, 1075",{},{"id":24,"text":1310,"url":24,"identifiers":1311},"10.1084\u002Fjem.182.6.1871",{"doi":1310},{"id":24,"text":1313,"url":24,"identifiers":1314},"Knippels LMJ, 1999, Immune‐mediated effects upon oral challenge of ovalbumin‐sensitized Brown Norway rats, further characterization of a rat food allergy model, 156, 161",{},{"id":1316,"createTime":1317,"updateTime":1317,"relativeEntities":1318,"slug":1319,"properties":1320,"entityType":130,"verifyStatus":467,"verifyTime":1334,"verifyNote":468,"syncStatus":23,"languages":1335,"translateLanguages":24,"viewCount":25,"primaryUrl":1336,"fullTextUrl":24,"authors":1337,"publicationType":236,"publisherRelationship":1413,"citationCount":1445,"citationInfo":1446,"publishDate":1458,"publishYear":1459,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1460,"isForceReanalyzing":447},"c79f3ed7-ee67-4fa5-8e26-b064a22e3d36","2024-09-29T22:11:42.763+00:00",[],"Immunoglobulin-G4-an-odd-antibody",{"mag":1321,"keywords":1323,"openalex":1324,"abstract":1326,"title":1328,"pm":1330,"doi":1332},{"VOID":1322},"2101939433",{},{"VOID":1325},"W2101939433",{"EN":1327},"\u003Cjats:title>Summary\u003C\u002Fjats:title>\u003Cjats:p>Despite its well‐known association with IgE‐mediated allergy, IgG4 antibodies still have several poorly understood characteristics. IgG4 is a very dynamic antibody: the antibody is involved in a continuous process of half‐molecules (i.e. a heavy and attached light‐chain) exchange. This process, also referred to as ‘Fab‐arm exchange’, results usually in asymmetric antibodies with two different antigen‐combining sites. While these antibodies are hetero‐ bivalent, they will behave as monovalent antibodies in most situations. Another aspect of IgG4, still poorly understood, is its tendency to mimic IgG rheumatoid factor (RF) activity by interacting with IgG on a solid support. In contrast to conventional RF, which binds via its variable domains, the activity of IgG4 is located in its constant domains. This is potentially a source of false positives in IgG4 antibody assay results. Because regulation of IgG4 production is dependent on help by T‐helper type 2 (Th2) cells, the IgG4 response is largely restricted to non‐microbial antigens. This Th2‐dependency associates the IgG4 and IgE responses. Another typical feature in the immune regulation of IgG4 is its tendency to appear only after prolonged immunization. In the context of IgE‐mediated allergy, the appearance of IgG4 antibodies is usually associated with a decrease in symptoms. This is likely to be due, at least in part, to an allergen‐blocking effect at the mast cell level and\u002For at the level of the antigen‐presenting cell (preventing IgE‐facilitated activation of T cells). In addition, the favourable association reflects the enhanced production of IL‐10 and other anti‐inflammatory cytokines, which drive the production of IgG4. While in general, IgG4 is being associated with non‐activating characteristics, in some situations IgG4 antibodies have an association with pathology. Two striking examples are pemphigoid diseases and sclerosing diseases such as autoimmune pancreatitis. The mechanistic basis for the association of IgG4 with these diseases is still enigmatic. However, the association with sclerosing diseases may reflect an excessive production of anti‐inflammatory cytokines triggering an overwhelming expansion of IgG4‐producing plasma cells. The bottom line for allergy diagnosis: IgG4 by itself is unlikely to be a cause of allergic symptoms. In general, the presence of allergen‐specific IgG4 indicates that anti‐inflammatory, tolerance‐inducing mechanisms have been activated. The existence of the IgG4 subclass, its up‐regulation by anti‐inflammatory factors and its own anti‐inflammatory characteristics may help the immune system to dampen inappropriate inflammatory reactions.\u003C\u002Fjats:p>",{"EN":1329},"Immunoglobulin G4: an odd antibody",{"VOID":1331},"19222496",{"VOID":1333},"10.1111\u002Fj.1365-2222.2009.03207.x","2024-09-29T22:11:42.762+00:00",[134],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1365-2222.2009.03207.x",[1338,1357,1374,1391],{"id":1339,"sortIndex":215,"researcher":24,"roles":1340,"affiliations":1341,"properties":1352},"d409ba8f-62aa-4768-b444-c3d2ced8e8e1",[],[1342],{"id":1343,"sortIndex":25,"affiliation":1344,"properties":24},"2c84be32-5767-48a1-8aff-94e68d91fde8",{"id":1345,"createTime":1346,"updateTime":1346,"relativeEntities":1347,"slug":1348,"properties":1349,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"b4f1a1ff-d83a-438f-b763-118a59f66c11","2024-09-29T22:11:42.777+00:00",[],"Sanquin-and-Academic-Medical-Centre-University-of-Amsterdam-Amsterdam-The-Netherlands",{"title":1350},{"EN":1351},"Sanquin and Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands",{"openalex":1353,"title":1355},{"VOID":1354},"A5057623947",{"EN":1356},"Steven O. 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II. IgG4 antibodies form small, nonprecipitating immune complexes due to functional monovalency, J Immunol, 137, 3566, 10.4049\u002Fjimmunol.137.11.3566",{"doi":1470},"10.4049\u002Fjimmunol.137.11.3566",{"id":24,"text":1472,"url":24,"identifiers":1473},"10.1042\u002Fbj2810317",{"doi":1472},{"id":24,"text":1475,"url":24,"identifiers":1476},"10.1016\u002F0161-5890(93)90432-B",{"doi":1475},{"id":24,"text":1478,"url":24,"identifiers":1479},"Schuurman J, 1997, Mouse\u002Fhuman chimeric IgG1 and IgG4 antibodies directed to the house dust mite allergen Der p 2, use in quantification of allergen specific IgG, 27, 1095",{},{"id":24,"text":1481,"url":24,"identifiers":1482},"Schuurman J, 1999, Normal human immunoglobulin G4 is bispecific, it has two different antigen-combining sites, 97, 693",{},{"id":24,"text":1484,"url":24,"identifiers":1485},"10.1046\u002Fj.0019-2805.2001.01341.x",{"doi":1484},{"id":24,"text":1487,"url":24,"identifiers":1488},"10.1126\u002Fscience.1144603",{"doi":1487},{"id":24,"text":1490,"url":24,"identifiers":1491},"10.1111\u002Fj.1365-2222.2007.02883.x",{"doi":1490},{"id":24,"text":1493,"url":24,"identifiers":1494},"Zack DJ, 1995, Localization of an Fc‐binding reactivity to the constant region of human IgG4. Implications for the pathogenesis of rheumatoid arthritis, J Immunol, 155, 5057, 10.4049\u002Fjimmunol.155.10.5057",{"doi":1495},"10.4049\u002Fjimmunol.155.10.5057",{"id":24,"text":1497,"url":24,"identifiers":1498},"10.1073\u002Fpnas.90.8.3730",{"doi":1497},{"id":24,"text":1500,"url":24,"identifiers":1501},"Jabara HH, 1993, Sequential switching from mu to epsilon via gamma 4 in human B cells stimulated with IL‐4 and hydrocortisone, J Immunol, 151, 4528, 10.4049\u002Fjimmunol.151.9.4528",{"doi":1502},"10.4049\u002Fjimmunol.151.9.4528",{"id":24,"text":1504,"url":24,"identifiers":1505},"10.1159\u002F000023918",{"doi":1504},{"id":24,"text":1507,"url":24,"identifiers":1508},"10.1159\u002F000024099",{"doi":1507},{"id":24,"text":1510,"url":24,"identifiers":1511},"Punnonen J, 1993, IL‐10 and viral IL‐10 prevent IL‐4‐induced IgE synthesis by inhibiting the accessory cell function of monocytes, J Immunol, 151, 1280, 10.4049\u002Fjimmunol.151.3.1280",{"doi":1512},"10.4049\u002Fjimmunol.151.3.1280",{"id":24,"text":1514,"url":24,"identifiers":1515},"10.1111\u002Fj.1398-9995.2008.01774.x",{"doi":1514},{"id":24,"text":1517,"url":24,"identifiers":1518},"Satoguina JS, 2005, T regulatory‐1 cells induce IgG4 production by B cells, role of IL-10, 174, 4718",{},{"id":24,"text":1520,"url":24,"identifiers":1521},"10.1016\u002Fj.cellimm.2005.01.001",{"doi":1520},{"id":24,"text":1523,"url":24,"identifiers":1524},"10.4049\u002Fjimmunol.181.3.1767",{"doi":1523},{"id":24,"text":1526,"url":24,"identifiers":1527},"10.1111\u002Fj.1600-065X.2008.00631.x",{"doi":1526},{"id":24,"text":1529,"url":24,"identifiers":1530},"Platts‐Mills T, 2001, Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen, a population-based cross-sectional study, 357, 752",{},{"id":24,"text":1532,"url":24,"identifiers":1533},"10.1159\u002F000091169",{"doi":1532},{"id":24,"text":1535,"url":24,"identifiers":1536},"10.1111\u002Fj.1365-2222.2005.02331.x",{"doi":1535},{"id":24,"text":1538,"url":24,"identifiers":1539},"10.1159\u002F000106318",{"doi":1538},{"id":24,"text":1541,"url":24,"identifiers":1542},"Akdis M., 2006, Healthy immune response to allergens, T regulatory cells and more, 18, 738",{},{"id":24,"text":1544,"url":24,"identifiers":1545},"10.1016\u002FS1286-4579(01)01449-6",{"doi":1544},{"id":24,"text":1547,"url":24,"identifiers":1548},"Platts‐Mills TA., 1979, Local production of IgG, IgA and IgE antibodies in grass pollen hay fever, J Immunol, 122, 2218, 10.4049\u002Fjimmunol.122.6.2218",{"doi":1549},"10.4049\u002Fjimmunol.122.6.2218",{"id":24,"text":1551,"url":24,"identifiers":1552},"Chapman MD, 1978, Measurement of IgG, IgA and IgE antibodies to Dermatophagoides pteronyssinus by antigen‐binding assay, using a partially purified fraction of mite extract (F4P1), Clin Exp Immunol, 34, 126",{},{"id":24,"text":1554,"url":24,"identifiers":1555},"10.1007\u002FBF02697369",{"doi":1554},{"id":24,"text":1557,"url":24,"identifiers":1558},"10.1159\u002F000090277",{"doi":1557},{"id":24,"text":1560,"url":24,"identifiers":1561},"Kotowicz K, 1993, Human immunoglobulin class and IgG subclass regulation, dual action of interleukin-4, 23, 2250",{},{"id":24,"text":1563,"url":24,"identifiers":1564},"Fujieda S, 1995, IL‐4 plus CD40 monoclonal antibody induces human B cells gamma subclass‐specific isotype switch, switching to gamma 1, gamma 3, and gamma 4, but not gamma 2, 155, 2318",{},{"id":24,"text":1566,"url":24,"identifiers":1567},"10.4049\u002Fjimmunol.173.7.4529",{"doi":1566},{"id":24,"text":1569,"url":24,"identifiers":1570},"Aalberse RC, 1983, Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4‐restricted response, J Immunol, 130, 722, 10.4049\u002Fjimmunol.130.2.722",{"doi":1571},"10.4049\u002Fjimmunol.130.2.722",{"id":24,"text":1573,"url":24,"identifiers":1574},"10.1111\u002Fj.1365-2222.1991.tb00809.x",{"doi":1573},{"id":24,"text":1576,"url":24,"identifiers":1577},"10.1111\u002Fj.1365-2222.2007.02749.x",{"doi":1576},{"id":24,"text":1579,"url":24,"identifiers":1580},"Hussain R, 1992, Control of allergic reactivity in human filariasis, predominant localization of blocking antibody to the IgG4 subclass, 148, 2731",{},{"id":24,"text":1582,"url":24,"identifiers":1583},"Yazdanbakhsh M, 2001, Th2 responses without atopy, immunoregulation in chronic helminth infections and reduced allergic disease, 22, 372",{},{"id":24,"text":1585,"url":24,"identifiers":1586},"10.1038\u002F217174a0",{"doi":1585},{"id":24,"text":1588,"url":24,"identifiers":1589},"10.1055\u002Fs-0037-1613257",{"doi":1588},{"id":24,"text":1591,"url":24,"identifiers":1592},"10.1111\u002Fj.1365-2141.2008.07232.x",{"doi":1591},{"id":24,"text":1594,"url":24,"identifiers":1595},"Wouters D, 2007, Human antichimeric antibodies to infliximab and infusion‐related allergic reactions in patients with rheumatoid arthritis, Allergy Clin Immunol Int, 198",{},{"id":24,"text":1597,"url":24,"identifiers":1598},"10.1159\u002F000236090",{"doi":1597},{"id":24,"text":1600,"url":24,"identifiers":1601},"Stapel SO, 2008, Testing for IgG4 against foods is not recommended as a diagnostic tool, EAACI task force report, 63, 793",{},{"id":24,"text":1603,"url":24,"identifiers":1604},"10.4049\u002Fjimmunol.172.5.3252",{"doi":1603},{"id":24,"text":1606,"url":24,"identifiers":1607},"Lessof MH, 1978, Effects of passive antibody in bee venom anaphylaxis, Johns Hopkins Med J, 142, 1",{},{"id":24,"text":1609,"url":24,"identifiers":1610},"Aalberse RC, 1983, Clinical reviews in allergy, 289",{},{"id":24,"text":1612,"url":24,"identifiers":1613},"10.1007\u002Fs00403-007-0734-0",{"doi":1612},{"id":24,"text":1615,"url":24,"identifiers":1616},"10.1111\u002Fj.1600-0625.2005.00367.x",{"doi":1615},{"id":24,"text":1618,"url":24,"identifiers":1619},"10.1056\u002FNEJM198906013202206",{"doi":1618},{"id":24,"text":1621,"url":24,"identifiers":1622},"10.1016\u002Fj.clim.2006.03.006",{"doi":1621},{"id":24,"text":1624,"url":24,"identifiers":1625},"10.1111\u002Fj.1582-4934.2007.00081.x",{"doi":1624},{"id":24,"text":1627,"url":24,"identifiers":1628},"Neild GH, 2006, Hyper‐IgG4 disease, report and characterisation of a new disease, 4, 23",{},{"id":24,"text":1630,"url":24,"identifiers":1631},"10.1159\u002F000232784",{"doi":1630},{"id":24,"text":1633,"url":24,"identifiers":1634},"10.1159\u002F000233000",{"doi":1633},{"id":24,"text":1636,"url":24,"identifiers":1637},"10.1111\u002Fj.1365-2222.1982.tb01643.x",{"doi":1636},{"id":24,"text":1639,"url":24,"identifiers":1640},"Malbec O, 1998, Fc epsilon receptor I‐associated lyn‐dependent phosphorylation of Fc gamma receptor IIB during negative regulation of mast cell activation, J Immunol, 160, 1647, 10.4049\u002Fjimmunol.160.4.1647",{"doi":1641},"10.4049\u002Fjimmunol.160.4.1647",{"id":24,"text":1643,"url":24,"identifiers":1644},"Schuurman J, 1998, Complementation of Der P 2‐induced histamine release from human basophils sensitized with monoclonal IgE, not only by IgE, but also by IgG antibodies directed to a nonoverlapping epitope of Der p 2, 101, 404",{},{"id":24,"text":1646,"url":24,"identifiers":1647},"Mudde GC, 1990, IgE, an immunoglobulin specialized in antigen capture, 11, 440",{},{"id":24,"text":1649,"url":24,"identifiers":1650},"Van der Heijden FL, 1993, Serum‐IgE‐facilitated allergen presentation in atopic disease, J Immunol, 150, 3643, 10.4049\u002Fjimmunol.150.8.3643",{"doi":1651},"10.4049\u002Fjimmunol.150.8.3643",{"id":24,"text":1653,"url":24,"identifiers":1654},"Van Neerven RJ, 1999, Blocking antibodies induced by specific allergy vaccination prevent the activation of CD4+ T cells by inhibiting serum‐IgE‐facilitated allergen presentation, J Immunol, 163, 2944, 10.4049\u002Fjimmunol.163.5.2944",{"doi":1655},"10.4049\u002Fjimmunol.163.5.2944",{"id":1657,"createTime":1658,"updateTime":1658,"relativeEntities":1659,"slug":1660,"properties":1661,"entityType":130,"verifyStatus":467,"verifyTime":1675,"verifyNote":468,"syncStatus":23,"languages":1676,"translateLanguages":24,"viewCount":25,"primaryUrl":1677,"fullTextUrl":24,"authors":1678,"publicationType":236,"publisherRelationship":1754,"citationCount":1787,"citationInfo":1788,"publishDate":1790,"publishYear":1791,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1792,"isForceReanalyzing":447},"d3dd3538-ac48-448f-ba30-3e0cddf35768","2025-02-03T22:04:05.796+00:00",[],"Comparison-of-four-allergen-sampling-methods-in-conventional-and-allergy-prevention-classrooms",{"mag":1662,"keywords":1664,"openalex":1665,"abstract":1667,"title":1669,"pm":1671,"doi":1673},{"VOID":1663},"2027365524",{},{"VOID":1666},"W2027365524",{"EN":1668},"\u003Cjats:title>Summary\u003C\u002Fjats:title>\u003Cjats:p>\u003Cjats:bold>Background\u003C\u002Fjats:bold> Several allergen‐sampling methods are used to assess level of personal or indirect exposure to cat in homes, schools and other public buildings and working environments.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Objective\u003C\u002Fjats:bold> To compare four different allergen‐sampling methods (dust collectors, Petri dishes, person‐carried pumps and intranasal samplers) by simultaneous sampling in classrooms and to compare the cat allergen levels between conventional classrooms and allergy prevention classrooms. Another aim was to relate the results to self‐reported frequency of allergy and asthma symptoms among the children, to their perception of the school environment.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Methods\u003C\u002Fjats:bold> Among all compulsory schools (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 257) in the Stockholm suburban area, 35 classrooms (five with implemented allergy prevention measures, seven with additional cleaning and 23 with normal cleaning routines) were chosen for allergen‐sampling. Dust collectors (two models), Petri dishes, person‐carried pumps and intranasal samplers were used simultaneously. All children (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 829) received a self‐administered questionnaire which included questions about home and school environment, allergic disease, asthma symptoms and pet contact.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Results\u003C\u002Fjats:bold> The correlation between sampling methods was generally poor. Furthermore, there was no significant difference in allergen levels between allergy prevention and allergen avoidance classes compared to conventional classes. Median levels were generally, but not significantly, lower in classes with few cat owners, compared to classes with many cat owners. Children in allergy prevention classes were more satisfied with the indoor air quality and cleaning than children attending classes with fewer or no allergy prevention measures (\u003Cjats:italic>P\u003C\u002Fjats:italic> < 0.0001). Nine per cent of all children reported allergic symptoms while at school.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Conclusion\u003C\u002Fjats:bold> The lack of correlation between sampling methods used simultaneously demonstrates the difficulty in assessing allergen levels in schools and similar environments. The implemented intervention measures (allergy prevention\u002Fallergen avoidance) did not influence cat allergen levels at school.\u003C\u002Fjats:p>",{"EN":1670},"Comparison of four allergen‐sampling methods in conventional and allergy prevention classrooms",{"VOID":1672},"12653171",{"VOID":1674},"10.1046\u002Fj.1365-2222.2002.01553.x","2025-02-03T22:04:05.795+00:00",[134],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1046\u002Fj.1365-2222.2002.01553.x",[1679,1700,1715,1734],{"id":1680,"sortIndex":139,"researcher":24,"roles":1681,"affiliations":1682,"properties":1693},"310d80fc-5a67-4515-8c9d-23bf584591d9",[],[1683],{"id":1684,"sortIndex":25,"affiliation":1685,"properties":24},"bbb60296-9b73-4dee-97de-b2f391d6fa23",{"id":1686,"createTime":1687,"updateTime":1687,"relativeEntities":1688,"slug":1689,"properties":1690,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"bda173ed-e35a-455a-bf35-e7bedf1545f4","2025-02-03T22:04:05.985+00:00",[],"Lung-and-Allergy-Research-National-Institute-of-Environmental-Medicine-Karolinska-Institute-and",{"title":1691},{"EN":1692},"Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institute and",{"openalex":1694,"orcid":1696,"title":1698},{"VOID":1695},"A5105458924",{"VOID":1697},"https:\u002F\u002Forcid.org\u002F0000-0003-0398-0289",{"EN":1699},"Kristin Larsson",{"id":1701,"sortIndex":215,"researcher":24,"roles":1702,"affiliations":1703,"properties":1710},"773ce043-1d12-4a28-a6d6-6a7ebbe70e71",[],[1704],{"id":1705,"sortIndex":25,"affiliation":1706,"properties":24},"471aa01b-bf82-4604-b188-1d714c486716",{"id":1686,"createTime":1687,"updateTime":1687,"relativeEntities":1707,"slug":1689,"properties":1708,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1709},{"EN":1692},{"openalex":1711,"title":1713},{"VOID":1712},"A5056027241",{"EN":1714},"Anne Renström",{"id":1716,"sortIndex":25,"researcher":24,"roles":1717,"affiliations":1718,"properties":1729},"a8788bc3-16cf-46b8-ad3c-8df203564f48",[],[1719],{"id":1720,"sortIndex":25,"affiliation":1721,"properties":24},"8fe5dee3-2b2a-4428-899a-f553b0254cc3",{"id":1722,"createTime":1723,"updateTime":1723,"relativeEntities":1724,"slug":1725,"properties":1726,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"5c7a9046-970f-4745-9ec0-4ed9f27206f3","2025-02-03T22:04:05.900+00:00",[],"Lung-and-Allergy-Research-National-Institute-of-Environmental-Medicine-Krolinska-Institute-Stotcholm-Sweden-",{"title":1727},{"EN":1728},"Lung and Allergy Research, National Institute of Environmental Medicine, Krolinska Institute, Stotcholm, Sweden.",{"openalex":1730,"title":1732},{"VOID":1731},"A5055645905",{"EN":1733},"Anne-Sophie Karlsson",{"id":1735,"sortIndex":163,"researcher":24,"roles":1736,"affiliations":1737,"properties":1749},"821262dc-1b17-42b5-95f4-0cc9c0e8702b",[],[1738],{"id":1739,"sortIndex":25,"affiliation":1740,"properties":24},"c4a8cdec-7638-4960-8ad0-24a34df17dbb",{"id":1741,"createTime":1742,"updateTime":1743,"relativeEntities":1744,"slug":1745,"properties":1746,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"9ec59cf2-a2d5-40b6-b0a8-4928fee19f32","2024-04-16T17:36:12.473+00:00","2025-02-03T22:04:06.049+00:00",[],"National-Institute-for-Working-Life-Stockholm-Sweden",{"title":1747},{"EN":1748},"National Institute for Working Life, Stockholm, Sweden",{"openalex":1750,"title":1752},{"VOID":1751},"A5021025563",{"EN":1753},"Marie Hedrén",{"url":24,"publisher":1755,"properties":1780},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1756,"slug":10,"properties":1757,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1763,"manageAffiliations":1764,"indexDatabases":1765,"url":107,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1758,"issn":1759,"introduce":1760,"eissn":1761,"title":1762},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1766,1773],{"id":68,"indexDatabase":1767,"url":81,"indexYears":82,"academicFieldIds":1772,"indexDatabaseRanking":86},{"id":70,"createTime":71,"updateTime":72,"relativeEntities":1768,"label":1769,"description":1770,"key":78,"publicationTags":1771,"standard":24},[],{"EN":75,"VI":75},{"EN":75,"VI":77},[80],[84,85],{"id":88,"indexDatabase":1774,"url":103,"indexYears":24,"academicFieldIds":1779,"indexDatabaseRanking":24},{"id":90,"createTime":91,"updateTime":92,"relativeEntities":1775,"label":1776,"description":1777,"key":99,"publicationTags":1778,"standard":24},[],{"EN":95,"VI":95},{"VI":97,"EN":98},[101,102],[105,106],{"volume":1781,"pages":1783,"issue":1785},{"VOID":1782},"32",{"VOID":1784},"1776-1781",{"VOID":1786},"12",28,{"total":1787,"publishYear":24,"statisticByYear":1789},{"2012":163,"2013":139,"2014":163,"2015":215,"2018":215,"2022":215},"2002-12-01",2002,[1793,1796,1799,1802,1805,1808,1811,1814,1818,1821,1824,1827,1830,1833,1836,1839,1842,1845,1848,1851,1854],{"id":24,"text":1794,"url":24,"identifiers":1795},"10.1111\u002Fj.1399-3038.1995.tb00379.x",{"doi":1794},{"id":24,"text":1797,"url":24,"identifiers":1798},"10.1006\u002Fmeth.1997.0495",{"doi":1797},{"id":24,"text":1800,"url":24,"identifiers":1801},"10.1034\u002Fj.1398-9995.1999.00062.x",{"doi":1800},{"id":24,"text":1803,"url":24,"identifiers":1804},"10.1016\u002FS0091-6749(96)80064-9",{"doi":1803},{"id":24,"text":1806,"url":24,"identifiers":1807},"10.1016\u002F0091-6749(89)90014-6",{"doi":1806},{"id":24,"text":1809,"url":24,"identifiers":1810},"10.1385\u002FCRIAI:18:3:341",{"doi":1809},{"id":24,"text":1812,"url":24,"identifiers":1813},"10.1164\u002Fajrccm.155.1.9001295",{"doi":1812},{"id":24,"text":1815,"url":24,"identifiers":1816},"ToveyER MarksGB MatthewsM GreenWF WoolcockA.Changes in mite allergen Der p 1 in house dust following spraying with tannic acid\u002Facaricide solution.Clin Exp Allergy1992; 22:67–74.",{"doi":1817},"10.1111\u002Fj.1365-2222.1992.tb00116.x",{"id":24,"text":1819,"url":24,"identifiers":1820},"10.1034\u002Fj.1398-9995.2002.1s3297.x",{"doi":1819},{"id":24,"text":1822,"url":24,"identifiers":1823},"10.1016\u002FS0140-6736(05)78870-X",{"doi":1822},{"id":24,"text":1825,"url":24,"identifiers":1826},"10.1016\u002FS0091-6749(99)70172-7",{"doi":1825},{"id":24,"text":1828,"url":24,"identifiers":1829},"10.1111\u002Fj.1399-3038.1998.tb00296.x",{"doi":1828},{"id":24,"text":1831,"url":24,"identifiers":1832},"10.1164\u002Fajrccm.163.3.2006114",{"doi":1831},{"id":24,"text":1834,"url":24,"identifiers":1835},"10.1046\u002Fj.1365-2222.1999.00566.x",{"doi":1834},{"id":24,"text":1837,"url":24,"identifiers":1838},"10.1111\u002Fj.1600-0668.1999.t01-2-00004.x",{"doi":1837},{"id":24,"text":1840,"url":24,"identifiers":1841},"10.5271\u002Fsjweh.416",{"doi":1840},{"id":24,"text":1843,"url":24,"identifiers":1844},"AnderssonK StridhG.Strategi för bättre luft i skolan‐enkäter inspektion och mätningar. Skolan‐En Arbetsmiljö För Alla? Solna:The Swedish Work Environmental Authority 1992;43–60(in Swedish).",{},{"id":24,"text":1846,"url":24,"identifiers":1847},"10.1164\u002Fajrccm\u002F141.2.361",{"doi":1846},{"id":24,"text":1849,"url":24,"identifiers":1850},"HollanderA.Laboratory animal allergy: allergen exposure assessment and epidemiological study of risk factors.PhD Thesis Wageningen: Wageningen Agricultural University 1997.",{},{"id":24,"text":1852,"url":24,"identifiers":1853},"10.1093\u002Fannhyg\u002F30.1.89",{"doi":1852},{"id":24,"text":1855,"url":24,"identifiers":1856},"SmedjeG. The indoor environment in schools‐respiratory effects and air quality.PhD Thesis Uppsala: Uppsala University 2000.",{},{"id":1858,"createTime":1859,"updateTime":1859,"relativeEntities":1860,"slug":1861,"properties":1862,"entityType":130,"verifyStatus":467,"verifyTime":1859,"verifyNote":468,"syncStatus":23,"languages":1876,"translateLanguages":24,"viewCount":25,"primaryUrl":1877,"fullTextUrl":24,"authors":1878,"publicationType":236,"publisherRelationship":1971,"citationCount":1454,"citationInfo":2003,"publishDate":2005,"publishYear":2006,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":2007,"isForceReanalyzing":447},"b5a5e466-bc6e-4b96-a7a1-c6973dad3ec9","2025-02-03T22:03:56.145+00:00",[],"Personal-exposure-to-allergenic-pollen-and-mould-spores-in-inland-New-South-Wales-Australia",{"mag":1863,"keywords":1865,"openalex":1866,"abstract":1868,"title":1870,"pm":1872,"doi":1874},{"VOID":1864},"2055454505",{},{"VOID":1867},"W2055454505",{"EN":1869},"\u003Cjats:sec>\u003Cjats:title>Background\u003C\u002Fjats:title>\u003Cjats:p>In inland NSW, Australia, allergic sensitization to the fungi \u003Cjats:italic>Alternaria\u003C\u002Fjats:italic> and \u003Cjats:italic>Cladosporium\u003C\u002Fjats:italic> and to pollen is common and an important risk factor for asthma.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Objective\u003C\u002Fjats:title>\u003Cjats:p>We report the results of a series of experiments designed to assess the nature of personal exposure to these airborne allergenic particles. We have tested the effect of exposure conditions and level of activity on measurements of the personal exposure.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Method\u003C\u002Fjats:title>\u003Cjats:p>Personal Air Samplers (PAS) and Nasal Air Samplers (NAS) were employed. NAS are fitted just inside the nose and collect inhaled particles by impaction, while the PAS use a pump‐operated filter with constant air flow (2 L\u002Fmin). Thirty‐three subjects (adults and children) used both NAS and PAS simultaneously for four one hour periods during which they performed activities or rested, both inside and outside their homes. Samples were analysed by light microscopy. \u003Cjats:italic>Alternaria \u003C\u002Fjats:italic>spores, \u003Cjats:italic>Cladosporium \u003C\u002Fjats:italic>spores, grass pollen and nongrass pollen were counted.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Both samplers detected substantial variation in exposure between subjects. Between members of the same household, the intrahouse correlation coefficient ranged from < 0 − 0.38. Levels of pollen grains and fungal spores inhaled were higher during periods of activity than during rest, and higher while subjects were outdoors than indoors. During the active outdoor period, the number of \u003Cjats:italic>Alternaria\u003C\u002Fjats:italic> spores inhaled ranged from 4 to 794 (median 11) spores\u002Fhr, \u003Cjats:italic>Cladosporium\u003C\u002Fjats:italic> from 0 to 396 (median 4) spores\u002Fhr, grass pollen from 0 to 81 (median 1) grains\u002Fhr and nongrass pollen from 0 to 72 (median 5) grains\u002Fhr.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusion\u003C\u002Fjats:title>\u003Cjats:p>This is the first study to quantify individual inhaled levels of allergenic fungal spores and pollen under normal domestic circumstances. Exposure can be substantial and highly variable between individuals. The amount of particles inhaled relates both to location of the individual and activity being performed, independent of age group.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":1871},"Personal exposure to allergenic pollen and mould spores in inland New South Wales, Australia",{"VOID":1873},"11122211",{"VOID":1875},"10.1046\u002Fj.1365-2222.2000.00966.x",[134],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1046\u002Fj.1365-2222.2000.00966.x",[1879,1900,1917,1945],{"id":1880,"sortIndex":139,"researcher":24,"roles":1881,"affiliations":1882,"properties":1893},"fe736783-7c65-4381-bb60-8908bae0546c",[],[1883],{"id":1884,"sortIndex":25,"affiliation":1885,"properties":24},"f8a807b6-dee1-4e19-84c2-ad3f6ad3571c",{"id":1886,"createTime":1887,"updateTime":1887,"relativeEntities":1888,"slug":1889,"properties":1890,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"d437d6e6-0161-4e04-9358-068467e46d4c","2025-02-03T22:03:56.188+00:00",[],"Institute-of-Respiratory-Medicine-The-Royal-Prince-Alfred-Hospital-Sydney-",{"title":1891},{"EN":1892},"Institute of Respiratory Medicine, The Royal Prince Alfred Hospital, Sydney,",{"openalex":1894,"orcid":1896,"title":1898},{"VOID":1895},"A5039913549",{"VOID":1897},"https:\u002F\u002Forcid.org\u002F0000-0002-8976-8053",{"EN":1899},"Guy B. Marks",{"id":1901,"sortIndex":163,"researcher":24,"roles":1902,"affiliations":1903,"properties":1910},"e21e49d7-c10c-4b72-b972-1c347762d69d",[],[1904],{"id":1905,"sortIndex":25,"affiliation":1906,"properties":24},"4b6f0cd3-7779-434a-ba71-bc0e4b346702",{"id":1886,"createTime":1887,"updateTime":1887,"relativeEntities":1907,"slug":1889,"properties":1908,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1909},{"EN":1892},{"openalex":1911,"orcid":1913,"title":1915},{"VOID":1912},"A5003840761",{"VOID":1914},"https:\u002F\u002Forcid.org\u002F0000-0001-7169-8299",{"EN":1916},"Wei Xuan",{"id":1918,"sortIndex":215,"researcher":24,"roles":1919,"affiliations":1920,"properties":1938},"f506fab2-d2b4-4b7b-b304-e37c3ebcd315",[],[1921,1927],{"id":1922,"sortIndex":215,"affiliation":1923,"properties":24},"94fd3d2b-fc2d-49e5-9985-7db0632c2188",{"id":1886,"createTime":1887,"updateTime":1887,"relativeEntities":1924,"slug":1889,"properties":1925,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1926},{"EN":1892},{"id":1928,"sortIndex":25,"affiliation":1929,"properties":24},"2c59057f-a3c8-4167-9599-e5bece19b8ed",{"id":1930,"createTime":1931,"updateTime":1932,"relativeEntities":1933,"slug":1934,"properties":1935,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"c2a024a7-708d-427d-b73c-d4cc578114d2","2023-12-14T07:59:30.433+00:00","2025-02-03T22:03:56.267+00:00",[],"Department-of-Medicine-The-University-of-Sydney-Sydney-Australia",{"title":1936},{"VI":1937},"Department of Medicine, The University of Sydney, Sydney, Australia",{"openalex":1939,"orcid":1941,"title":1943},{"VOID":1940},"A5019980206",{"VOID":1942},"https:\u002F\u002Forcid.org\u002F0000-0002-1802-7266",{"EN":1944},"Euan R. Tovey",{"id":1946,"sortIndex":25,"researcher":24,"roles":1947,"affiliations":1948,"properties":1966},"46be30fa-3c9c-463d-a480-c13f61b73732",[],[1949,1955],{"id":1950,"sortIndex":25,"affiliation":1951,"properties":24},"e993d1c2-e6fd-432f-a4f3-0dcdef37220e",{"id":1886,"createTime":1887,"updateTime":1887,"relativeEntities":1952,"slug":1889,"properties":1953,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1954},{"EN":1892},{"id":1956,"sortIndex":215,"affiliation":1957,"properties":24},"d2b5213c-7ae3-4960-932c-fb21ef34fa00",{"id":1958,"createTime":1959,"updateTime":1960,"relativeEntities":1961,"slug":1962,"properties":1963,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"03a8193d-416b-4b12-b1ee-535fc3e21350","2025-02-03T22:03:56.194+00:00","2025-06-11T16:58:58.384+00:00",[],"School-of-Biological-Sciences-The-University-of-Sydney-",{"title":1964},{"EN":1965},"School of Biological Sciences, The University of Sydney,",{"openalex":1967,"title":1969},{"VOID":1968},"A5056883154",{"EN":1970},"T. Z. Mitakakis",{"url":24,"publisher":1972,"properties":1997},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1973,"slug":10,"properties":1974,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1980,"manageAffiliations":1981,"indexDatabases":1982,"url":107,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1975,"issn":1976,"introduce":1977,"eissn":1978,"title":1979},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1983,1990],{"id":68,"indexDatabase":1984,"url":81,"indexYears":82,"academicFieldIds":1989,"indexDatabaseRanking":86},{"id":70,"createTime":71,"updateTime":72,"relativeEntities":1985,"label":1986,"description":1987,"key":78,"publicationTags":1988,"standard":24},[],{"EN":75,"VI":75},{"EN":75,"VI":77},[80],[84,85],{"id":88,"indexDatabase":1991,"url":103,"indexYears":24,"academicFieldIds":1996,"indexDatabaseRanking":24},{"id":90,"createTime":91,"updateTime":92,"relativeEntities":1992,"label":1993,"description":1994,"key":99,"publicationTags":1995,"standard":24},[],{"EN":95,"VI":95},{"VI":97,"EN":98},[101,102],[105,106],{"volume":1998,"pages":2000,"issue":2002},{"VOID":1999},"30",{"VOID":2001},"1733-1739",{"VOID":1786},{"total":1454,"publishYear":24,"statisticByYear":2004},{"2012":215,"2013":54,"2014":54,"2015":54,"2016":54,"2017":139,"2018":215,"2021":139,"2022":215},"2000-12-01",2000,[2008,2011,2014,2017,2020,2023,2026,2029,2031,2033,2036,2039,2042,2045,2049,2052,2055],{"id":24,"text":2009,"url":24,"identifiers":2010},"10.1111\u002Fj.1365-2222.1979.tb01539.x",{"doi":2009},{"id":24,"text":2012,"url":24,"identifiers":2013},"10.1016\u002FS0091-6749(97)70169-6",{"doi":2012},{"id":24,"text":2015,"url":24,"identifiers":2016},"10.5694\u002Fj.1326-5377.1995.tb126083.x",{"doi":2015},{"id":24,"text":2018,"url":24,"identifiers":2019},"10.1111\u002Fj.1365-2222.1993.tb00258.x",{"doi":2018},{"id":24,"text":2021,"url":24,"identifiers":2022},"10.1016\u002FS1081-1206(10)62410-6",{"doi":2021},{"id":24,"text":2024,"url":24,"identifiers":2025},"10.1016\u002FS0091-6749(99)70341-6",{"doi":2024},{"id":24,"text":2027,"url":24,"identifiers":2028},"10.1046\u002Fj.1365-2222.1999.00613.x",{"doi":2027},{"id":24,"text":1822,"url":24,"identifiers":2030},{"doi":1822},{"id":24,"text":1852,"url":24,"identifiers":2032},{"doi":1852},{"id":24,"text":2034,"url":24,"identifiers":2035},"10.1016\u002FS0197-2456(05)80019-4",{"doi":2034},{"id":24,"text":2037,"url":24,"identifiers":2038},"10.1016\u002FS0140-6736(86)90837-8",{"doi":2037},{"id":24,"text":2040,"url":24,"identifiers":2041},"10.1016\u002FS0007-1536(53)80034-3",{"doi":2040},{"id":24,"text":2043,"url":24,"identifiers":2044},"10.1093\u002Fannhyg\u002F34.6.553",{"doi":2043},{"id":24,"text":2046,"url":24,"identifiers":2047},"BlackleyC. Experimental Researchers on the Causes and Nature of Catarrhus Aestivus (hay fever or hay asthma). London: Ballierre Tindall & Cox Ltd;1873.",{"doi":2048},"10.1097\u002F00000441-187413300-00026",{"id":24,"text":2050,"url":24,"identifiers":2051},"Morrow BrownH. The relationship between aerobiology and allergology. In: Recent Trends in Aerobiology Allergy and Immunology (eds Agashe SN) New Dehli Oxford: IBH Publishing Co. Pty Ltd 1994:1–30.",{},{"id":24,"text":2053,"url":24,"identifiers":2054},"10.1016\u002F0091-6749(94)90352-2",{"doi":2053},{"id":24,"text":2056,"url":24,"identifiers":2057},"10.1111\u002Fj.1365-2672.1986.tb04303.x",{"doi":2056},{"id":2059,"createTime":2060,"updateTime":2060,"relativeEntities":2061,"slug":2062,"properties":2063,"entityType":130,"verifyStatus":467,"verifyTime":2060,"verifyNote":468,"syncStatus":23,"languages":2077,"translateLanguages":24,"viewCount":25,"primaryUrl":2078,"fullTextUrl":24,"authors":2079,"publicationType":236,"publisherRelationship":2202,"citationCount":2234,"citationInfo":2235,"publishDate":2237,"publishYear":2238,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":2239,"isForceReanalyzing":447},"5e7d9917-a090-4c11-a862-747e83b322c5","2024-10-13T21:44:07.625+00:00",[],"Increased-chitinase-expression-and-fungal-specific-antibodies-in-the-bronchoalveolar-lavage-fluid-of-asthmatic-children",{"mag":2064,"keywords":2066,"openalex":2067,"abstract":2069,"title":2071,"pm":2073,"doi":2075},{"VOID":2065},"2013987956",{},{"VOID":2068},"W2013987956",{"EN":2070},"\u003Cjats:title>Summary\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Background\u003C\u002Fjats:title>\u003Cjats:p>Increasing evidence highlights the contribution of chitinases and fungal infection to the development of asthma.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Objective\u003C\u002Fjats:title>\u003Cjats:p>The purpose of this study was to characterize chitinase expression and serological markers of fungal infection in children with severe asthma.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>Bronchoalveolar lavage fluid (\u003Cjats:styled-content style=\"fixed-case\">BALF\u003C\u002Fjats:styled-content>) was collected from children undergoing clinically indicated flexible bronchoscopy. A diagnosis of asthma was confirmed by pulmonary function testing. \u003Cjats:styled-content style=\"fixed-case\">BALF\u003C\u002Fjats:styled-content> was tested for chitinase activity and \u003Cjats:styled-content style=\"fixed-case\">YKL\u003C\u002Fjats:styled-content>‐40 (an enzymatically inactive chitinase) concentrations. Specimens were cultured for fungal organisms and tested for cryptococcal antigen by \u003Cjats:styled-content style=\"fixed-case\">ELISA\u003C\u002Fjats:styled-content>. \u003Cjats:styled-content style=\"fixed-case\">IgG\u003C\u002Fjats:styled-content> and \u003Cjats:styled-content style=\"fixed-case\">IgA\u003C\u002Fjats:styled-content> reactivity to whole extract fungal (\u003Cjats:styled-content style=\"fixed-case\">\u003Cjats:italic>A\u003C\u002Fjats:italic>\u003C\u002Fjats:styled-content>\u003Cjats:italic>spergillus fumigatus\u003C\u002Fjats:italic>, \u003Cjats:styled-content style=\"fixed-case\">\u003Cjats:italic>A\u003C\u002Fjats:italic>\u003C\u002Fjats:styled-content>\u003Cjats:italic>lternaria alternata\u003C\u002Fjats:italic>, \u003Cjats:styled-content style=\"fixed-case\">\u003Cjats:italic>C\u003C\u002Fjats:italic>\u003C\u002Fjats:styled-content>\u003Cjats:italic>ryptococcus neoformans\u003C\u002Fjats:italic> and \u003Cjats:styled-content style=\"fixed-case\">\u003Cjats:italic>C\u003C\u002Fjats:italic>\u003C\u002Fjats:styled-content>\u003Cjats:italic>andida albicans\u003C\u002Fjats:italic>) proteins were determined by immunoblot assay.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Among the 37 patients studied, 30 were asthmatic and 7 were non‐asthmatic. Asthmatics exhibited elevated serum \u003Cjats:styled-content style=\"fixed-case\">IgE\u003C\u002Fjats:styled-content> levels (median: 748 IU\u002FmL, \u003Cjats:styled-content style=\"fixed-case\">IQR\u003C\u002Fjats:styled-content>: 219–1765 IU\u002FmL). Chitinase activity was greater in the \u003Cjats:styled-content style=\"fixed-case\">BALF\u003C\u002Fjats:styled-content> of asthmatics (mean, 0.85 ± 1.2 U\u002FmL) compared with non‐asthmatics (mean: 0.23 ± 0.21 U\u002FmL, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.012). Likewise \u003Cjats:styled-content style=\"fixed-case\">YKL\u003C\u002Fjats:styled-content>‐40 concentrations were higher in the \u003Cjats:styled-content style=\"fixed-case\">BALF\u003C\u002Fjats:styled-content> of asthmatics and correlated with chitinase activity. There was a trend towards increased fungal‐specific \u003Cjats:styled-content style=\"fixed-case\">IgG\u003C\u002Fjats:styled-content> in the \u003Cjats:styled-content style=\"fixed-case\">BALF\u003C\u002Fjats:styled-content> of asthmatics compared with non‐asthmatics and for \u003Cjats:styled-content style=\"fixed-case\">\u003Cjats:italic>C\u003C\u002Fjats:italic>\u003C\u002Fjats:styled-content>\u003Cjats:italic>. albicans\u003C\u002Fjats:italic> this difference reached statistical significance. \u003Cjats:styled-content style=\"fixed-case\">IgA\u003C\u002Fjats:styled-content> reactivity to \u003Cjats:styled-content style=\"fixed-case\">\u003Cjats:italic>C\u003C\u002Fjats:italic>\u003C\u002Fjats:styled-content>\u003Cjats:italic>. neoformans\u003C\u002Fjats:italic> and \u003Cjats:styled-content style=\"fixed-case\">\u003Cjats:italic>A\u003C\u002Fjats:italic>\u003C\u002Fjats:styled-content>\u003Cjats:italic>. fumigatus\u003C\u002Fjats:italic> was greater in the \u003Cjats:styled-content style=\"fixed-case\">BALF\u003C\u002Fjats:styled-content> of asthmatics compared with non‐asthmatics.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions and Clinical Relevance\u003C\u002Fjats:title>\u003Cjats:p>Compared with non‐asthmatics, asthmatic children exhibited increased chitinase activity and increased \u003Cjats:styled-content style=\"fixed-case\">YKL\u003C\u002Fjats:styled-content>‐40 levels in \u003Cjats:styled-content style=\"fixed-case\">BALF\u003C\u002Fjats:styled-content>. Increased \u003Cjats:styled-content style=\"fixed-case\">IgG\u003C\u002Fjats:styled-content> and \u003Cjats:styled-content style=\"fixed-case\">IgA\u003C\u002Fjats:styled-content> reactivity to fungal proteins in the \u003Cjats:styled-content style=\"fixed-case\">BALF\u003C\u002Fjats:styled-content> of asthmatics may reflect a local response to fungal infection. Our findings are consistent with and suggest a role for chitinases in asthma pathogenesis among \u003Cjats:styled-content style=\"fixed-case\">B\u003C\u002Fjats:styled-content>ronx children and provide serological evidence of an association between fungal infection and severe asthma.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":2072},"Increased chitinase expression and fungal‐specific antibodies in the bronchoalveolar lavage fluid of asthmatic children",{"VOID":2074},"22092749",{"VOID":2076},"10.1111\u002Fj.1365-2222.2011.03886.x",[134],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1365-2222.2011.03886.x",[2080,2102,2134,2155,2170,2185],{"id":2081,"sortIndex":175,"researcher":24,"roles":2082,"affiliations":2083,"properties":2095},"65749e02-e689-4404-8fff-12b079c4b3ab",[],[2084],{"id":2085,"sortIndex":25,"affiliation":2086,"properties":24},"f91e7d16-23b1-4a4d-8ad3-25599c1957c0",{"id":2087,"createTime":2088,"updateTime":2089,"relativeEntities":2090,"slug":2091,"properties":2092,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"309bec24-a2f5-4364-86aa-8d409d33c718","2024-02-10T22:25:47.363+00:00","2024-10-13T21:44:07.657+00:00",[],"Department-of-Microbiology-and-Immunology-Albert-Einstein-College-of-Medicine-Bronx-NY-USA",{"title":2093},{"VI":2094},"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA",{"openalex":2096,"orcid":2098,"title":2100},{"VOID":2097},"A5077902719",{"VOID":2099},"https:\u002F\u002Forcid.org\u002F0000-0002-9402-9167",{"EN":2101},"Arturo Casadevall",{"id":2103,"sortIndex":54,"researcher":24,"roles":2104,"affiliations":2105,"properties":2127},"496a982d-fa18-49a7-8a19-ff3c61a27515",[],[2106,2117],{"id":2107,"sortIndex":215,"affiliation":2108,"properties":24},"e338e267-4dc3-405d-b98f-c6a9db310156",{"id":2109,"createTime":2110,"updateTime":2111,"relativeEntities":2112,"slug":2113,"properties":2114,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"75ec8599-b313-4785-b61e-3262357e1e36","2024-02-14T06:31:47.418+00:00","2024-10-13T21:44:07.667+00:00",[],"Department-of-Pediatrics-Cohen-Children-s-Medical-Center-New-Hyde-Park-NY-USA",{"title":2115},{"VI":2116},"Department of Pediatrics, Cohen Children’s Medical Center, New Hyde Park, NY, USA",{"id":2118,"sortIndex":25,"affiliation":2119,"properties":24},"67833c4c-dd3c-4be1-b088-de8b4e598297",{"id":2120,"createTime":2121,"updateTime":2121,"relativeEntities":2122,"slug":2123,"properties":2124,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"a2fd0c1d-b449-4fd5-80dc-f41bd7605c69","2024-10-13T21:44:07.641+00:00",[],"Department-of-Pediatrics-Childrens-Hospital-at-Montefiore-and-Albert-Einstein-College-of-Medicine",{"title":2125},{"EN":2126},"Department of Pediatrics, Childrens' Hospital at Montefiore and Albert Einstein College of Medicine",{"openalex":2128,"orcid":2130,"title":2132},{"VOID":2129},"A5021844056",{"VOID":2131},"https:\u002F\u002Forcid.org\u002F0000-0003-3554-7201",{"EN":2133},"Alfin G. 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NH., 1973, Quantitative immunoelectrophoretic methods as tools for a polyvalent approach to standardization in the immunochemistry of Candida albicans, Infect Immun, 7, 949, 10.1128\u002Fiai.7.6.949-960.1973",{"doi":2535},"10.1128\u002Fiai.7.6.949-960.1973",{"id":24,"text":2537,"url":24,"identifiers":2538},"Manning M, 1980, Analysis of cytoplasmic antigens of the yeast and mycelial phases of Candida albicans by two‐dimensional electrophoresis, Infect Immun, 30, 484, 10.1128\u002Fiai.30.2.484-495.1980",{"doi":2539},"10.1128\u002Fiai.30.2.484-495.1980",{"id":24,"text":2541,"url":24,"identifiers":2542},"10.1111\u002Fj.1365-2222.1976.tb01410.x",{"doi":2541},{"id":24,"text":2544,"url":24,"identifiers":2545},"Ishiguro A, 1992, Identification of Candida albicans antigens reactive with Immunoglobulin E antibody of human sera, Infect Immunol, 60, 1550, 10.1128\u002Fiai.60.4.1550-1557.1992",{"doi":2546},"10.1128\u002Fiai.60.4.1550-1557.1992",{"id":24,"text":2548,"url":24,"identifiers":2549},"10.1159\u002F000234572",{"doi":2548},{"id":24,"text":2551,"url":24,"identifiers":2552},"10.1111\u002Fj.1365-2222.1993.tb00879.x",{"doi":2551},{"id":24,"text":2554,"url":24,"identifiers":2555},"10.1016\u002FS0140-6736(84)91618-0",{"doi":2554},{"id":24,"text":2557,"url":24,"identifiers":2558},"10.1111\u002Fj.1574-6968.1989.tb03413.x",{"doi":2557},{"id":24,"text":2560,"url":24,"identifiers":2561},"Strockbine NA, 1984, Identification and molecular weight characterization of antigens from Candida albicans that are recognized by human sera, Infect Immunol, 43, 715, 10.1128\u002Fiai.43.2.715-721.1984",{"doi":2562},"10.1128\u002Fiai.43.2.715-721.1984",{"id":24,"text":2564,"url":24,"identifiers":2565},"Mason AB, 1989, Enolase activity associated with a Candida albicans cytoplasmic antigen, Yeast, 5, 231",{},{"id":24,"text":2567,"url":24,"identifiers":2568},"10.1038\u002Ficb.1990.24",{"doi":2567},{"id":24,"text":2570,"url":24,"identifiers":2571},"10.1111\u002Fj.1398-9995.1993.tb00737.x",{"doi":2570},{"id":24,"text":2573,"url":24,"identifiers":2574},"10.1111\u002Fj.1365-2222.1994.tb00241.x",{"doi":2573},{"id":2576,"createTime":2577,"updateTime":2577,"relativeEntities":2578,"slug":2579,"properties":2580,"entityType":130,"verifyStatus":467,"verifyTime":2594,"verifyNote":468,"syncStatus":23,"languages":2595,"translateLanguages":24,"viewCount":25,"primaryUrl":2596,"fullTextUrl":24,"authors":2597,"publicationType":236,"publisherRelationship":2705,"citationCount":2737,"citationInfo":2738,"publishDate":2740,"publishYear":2741,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":2742,"isForceReanalyzing":447},"62b2a24b-6d35-4a46-ae8d-9dd7ffc2501f","2024-09-04T21:39:49.839+00:00",[],"Predominance-of-the-major-allergen-i-Alt-a-i-I-in-i-Alternaria-i-sensitized-patients",{"mag":2581,"keywords":2583,"openalex":2584,"abstract":2586,"title":2588,"pm":2590,"doi":2592},{"VOID":2582},"1997511722",{},{"VOID":2585},"W1997511722",{"EN":2587},"\u003Cjats:title>Summary\u003C\u002Fjats:title>\u003Cjats:p>Thirty‐nine patients sensitized to \u003Cjats:italic>Alternaria\u003C\u002Fjats:italic> were evaluated using titrated skin‐prick test (SPT), histamine release studies (HR), inhibition of RAST and immunoblotting studies. To determine the relevance of the major allergen, \u003Cjats:italic>Alt a\u003C\u002Fjats:italic> I, specific rabbit antibodies against \u003Cjats:italic>Alt a\u003C\u002Fjats:italic> I and \u003Cjats:italic>Alt a\u003C\u002Fjats:italic> B were used. The antibodies were preincubated at different concentrations: (i) with the \u003Cjats:italic>Alternaria\u003C\u002Fjats:italic> allergen dose required for maximum response in the HR assay (10 BU\u002Fml) and (ii) with the \u003Cjats:italic>Alternaria\u003C\u002Fjats:italic> antigen coupled to RAST paper discs (1000 BU\u002Fdisc). Dose dependent inhibition of histamine release (\u003Cjats:italic>n\u003C\u002Fjats:italic>= 30, x̄= 80%± 4%, IC30 = 0.69 μg\u002Fml) and of RAST (\u003Cjats:italic>n\u003C\u002Fjats:italic>= 7, IC30 = 4.4 μg\u002Fml) was found in all patients sensitized to \u003Cjats:italic>Alternaria\u003C\u002Fjats:italic> as indicated by allergen induced HR. The greater the response to \u003Cjats:italic>Alternaria\u003C\u002Fjats:italic> in HR, the higher the antibody concentrations necessary for inhibition (\u003Cjats:italic>P\u003C\u002Fjats:italic><0.05). Immunoblot experiments (\u003Cjats:italic>n\u003C\u002Fjats:italic>=25) using SDS‐PAGE showed in all cases IgE‐ and IgG binding at approximately 28 kD, which is the size reported for the major allergen. \u003Cjats:italic>All a\u003C\u002Fjats:italic> I. In two cases, slight IgE binding at 45 and 66 kD was also found, while in two other patients, only IgE binding at 66 kD was seen. Our findings emphasize the major importance of \u003Cjats:italic>Alt a\u003C\u002Fjats:italic> I in patients sensitized to \u003Cjats:italic>Alternaria\u003C\u002Fjats:italic>.\u003C\u002Fjats:p>",{"EN":2589},"Predominance of the major allergen (\u003Ci>Alt a\u003C\u002Fi> I) in \u003Ci>Alternaria\u003C\u002Fi> sensitized patients",{"VOID":2591},"7682472",{"VOID":2593},"10.1111\u002Fj.1365-2222.1993.tb00884.x","2024-09-04T21:39:49.838+00:00",[134],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1365-2222.1993.tb00884.x",[2598,2618,2637,2652,2673,2690],{"id":2599,"sortIndex":175,"researcher":24,"roles":2600,"affiliations":2601,"properties":2613},"3daa2f4f-82e1-4b6e-8d76-5411393eca39",[],[2602],{"id":2603,"sortIndex":25,"affiliation":2604,"properties":24},"0ae5b4ac-6521-4006-8365-3b2d12855521",{"id":2605,"createTime":2606,"updateTime":2607,"relativeEntities":2608,"slug":2609,"properties":2610,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"90ed8c2e-9044-44f4-8d31-8583adceefab","2024-01-08T12:02:55.664+00:00","2024-09-04T21:39:49.890+00:00",[],"ALK-Research-Horsholm-Denmark",{"title":2611},{"VI":2612},"ALK Research, Horsholm, Denmark",{"openalex":2614,"title":2616},{"VOID":2615},"A5020848415",{"EN":2617},"Henning Løwenstein",{"id":2619,"sortIndex":54,"researcher":24,"roles":2620,"affiliations":2621,"properties":2632},"121c954e-c807-4a0c-a434-27ee86808bee",[],[2622],{"id":2623,"sortIndex":25,"affiliation":2624,"properties":24},"01111535-8806-4ee6-9f2f-d71be1fc1e75",{"id":2625,"createTime":2626,"updateTime":2626,"relativeEntities":2627,"slug":2628,"properties":2629,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"24d33062-4ba2-4463-b988-143077db8e95","2024-09-04T21:39:49.866+00:00",[],"Department-of-Clinical-Immunology-unit-Asthma-Outpatient-Department-Universt%C3%A4tsklinikum-Rudolf-Virchow-Freie-Universit%C3%A4t-Berlin-Germany",{"title":2630},{"EN":2631},"Department of Clinical Immunology unit Asthma Outpatient Department, Universtätsklinikum Rudolf Virchow, Freie Universität Berlin, Germany",{"openalex":2633,"title":2635},{"VOID":2634},"A5013177268",{"EN":2636},"G. 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XIVth Congr of the EAACI 1989, Allergologie, 12, 21",{},{"id":24,"text":2786,"url":24,"identifiers":2787},"Matthiesen F, 1988, Quantitative determinations of allergenic components in Cladasporiun and Alternaria, NER Allergy Proc, 9, 261",{},{"id":24,"text":2789,"url":24,"identifiers":2790},"10.1111\u002Fj.1398-9995.1992.tb02082.x",{"doi":2789},{"id":24,"text":2792,"url":24,"identifiers":2793},"MatthiesenF FribergL OlsenM LøwensteinH.Purification and characterisation of the major allergen ofAlternaria alternata Alt AI.J Allergy Clin Immunol1993 in press.",{},{"id":24,"text":2795,"url":24,"identifiers":2796},"10.1111\u002Fj.1365-3083.1973.tb03798.x",{"doi":2795},{"id":24,"text":2798,"url":24,"identifiers":2799},"Sirangian RP., 1977, Automated histamine analysis for in vitro allergen testing—II. Correlation of skin tests results with in vitro whole blood histamine release in 82 patients, J Allergy Clin Immunol, 59, 214",{},{"id":24,"text":2801,"url":24,"identifiers":2802},"Neville DM., 1971, Molecular weight determination of protein dodecyl sulfate complexes by gel eleclrophoresis in a discontinuous buffer system, J Biol Chem, 24, 6328, 10.1016\u002FS0021-9258(18)61792-2",{"doi":2803},"10.1016\u002FS0021-9258(18)61792-2",{"id":24,"text":2805,"url":24,"identifiers":2806},"10.1159\u002F000234608",{"doi":2805},{"id":24,"text":2808,"url":24,"identifiers":2809},"OstergaardPA KaadPH SchwartzB IngemannL.Bronchial provocation and histamine release test in asthmatic children with mold allergy.Annual meeting of the EAACI1985 Stockholm (abstract 120).",{},{"id":24,"text":2811,"url":24,"identifiers":2812},"10.1111\u002Fj.1398-9995.1980.tb01784.x",{"doi":2811},{"id":24,"text":2814,"url":24,"identifiers":2815},"MacGlashan DW, 1986, Characteristics of human basophil sulfidopeptide leukotriene release: reeasibility defined as the ability of the basophil to correspond to dimeric cross‐links, J Immunol, 136, 2231, 10.4049\u002Fjimmunol.136.6.2231",{"doi":2816},"10.4049\u002Fjimmunol.136.6.2231",{"id":24,"text":2818,"url":24,"identifiers":2819},"10.1016\u002F0091-6749(90)90046-7",{"doi":2818},{"id":24,"text":2821,"url":24,"identifiers":2822},"10.1016\u002F0091-6749(83)90544-4",{"doi":2821},{"id":24,"text":2824,"url":24,"identifiers":2825},"Steward MW., 1983, Antibodies: their structure and function",{},{"id":24,"text":2827,"url":24,"identifiers":2828},"10.1159\u002F000234085",{"doi":2827},{"id":24,"text":2830,"url":24,"identifiers":2831},"Lombardero M, 1988, Immunchemische und biologische Charakterisierung eines Referenzexlrakles aus Alternaia alternata, Allergologie, 12, 509",{},{"id":24,"text":2833,"url":24,"identifiers":2834},"10.1016\u002F0022-1759(91)90254-D",{"doi":2833},{"id":24,"text":2836,"url":24,"identifiers":2837},"10.1016\u002F0091-6749(91)90124-7",{"doi":2836},{"id":24,"text":2839,"url":24,"identifiers":2840},"10.1016\u002F0091-6749(91)90247-L",{"doi":2839},{"id":24,"text":2842,"url":24,"identifiers":2843},"10.1159\u002F000232782",{"doi":2842},{"id":24,"text":2845,"url":24,"identifiers":2846},"10.1016\u002F0161-5890(91)90154-C",{"doi":2845},{"id":2848,"createTime":2849,"updateTime":2849,"relativeEntities":2850,"slug":2851,"properties":2852,"entityType":130,"verifyStatus":467,"verifyTime":2849,"verifyNote":468,"syncStatus":23,"languages":2866,"translateLanguages":24,"viewCount":25,"primaryUrl":2867,"fullTextUrl":24,"authors":2868,"publicationType":236,"publisherRelationship":3004,"citationCount":54,"citationInfo":3037,"publishDate":3039,"publishYear":3040,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":3041,"isForceReanalyzing":447},"d25f1794-cc8a-475f-9d43-66feded84063","2025-02-07T21:38:45.120+00:00",[],"Influence-of-viral-infection-on-the-development-of-nasal-hypersensitivity",{"mag":2853,"keywords":2855,"openalex":2856,"abstract":2858,"title":2860,"pm":2862,"doi":2864},{"VOID":2854},"2092333303",{},{"VOID":2857},"W2092333303",{"EN":2859},"\u003Cjats:title>Summary\u003C\u002Fjats:title>\u003Cjats:p>\u003Cjats:bold>Background\n\t\t\t\t\t\u003C\u002Fjats:bold> The underlying relationship between viral infections and allergic diseases of the upper respiratory tract has not been well clarified.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Methods\n\t\t\t\t\t\u003C\u002Fjats:bold> In order to clarify the relationship between viral infection and nasal hypersensitivity, mice were sensitized with ovalbumin (OVA) and then infected intranasally with respiratory syncytial virus (RSV), after which their nasal sensitivity to histamine or antigen was examined.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Results\n\t\t\t\t\t\u003C\u002Fjats:bold> Non‐sensitized mice showed transient mild nasal hypersensitivity following nasal administration of histamine after intranasal RSV inoculation. In mice sensitized with OVA, RSV infection significantly exaggerated their nasal hypersensitivity to histamine and OVA. Treatment of these mice with a neurokinin (NK)‐1\u002FNK‐2 receptor antagonist, but not with anti‐IL‐5 antibodies, reduced their hypersensitivity. The infiltration of nasal mucosa with eosinophils was temporarily associated with accelerated rate of RSV elimination in these animals.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Conclusion\n\t\t\t\t\t\u003C\u002Fjats:bold> RSV infection induced transient nasal hypersensitivity. Several mechanisms, including impairment of nasal epithelial cells are thought to mediate this effect. 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antibodies after respiratory syncytial virus bronchiolitis, a prospective cohort study with matched controls, 95, 500",{},{"id":24,"text":3095,"url":24,"identifiers":3096},"10.1016\u002FS0022-3476(84)80005-0",{"doi":3095},{"id":24,"text":3098,"url":24,"identifiers":3099},"Eisen AH, 1963, The relationship of acute bronchiolitis to bronchial asthma‐a 4 to 14‐year follow up, Pediatrics, 31, 859, 10.1542\u002Fpeds.31.5.859",{"doi":3100},"10.1542\u002Fpeds.31.5.859",{"id":24,"text":3102,"url":24,"identifiers":3103},"10.1136\u002Fbmj.1.6104.11",{"doi":3102},{"id":24,"text":3105,"url":24,"identifiers":3106},"10.1002\u002Fppul.1950150104",{"doi":3105},{"id":24,"text":3108,"url":24,"identifiers":3109},"10.1136\u002Fbmj.284.6330.1665",{"doi":3108},{"id":24,"text":3111,"url":24,"identifiers":3112},"Ueba O., 1978, Respiratory syncytial virus 1 concentration and purification of the infectious virus, Acta Med Okayama, 32, 265",{},{"id":24,"text":3114,"url":24,"identifiers":3115},"Morimoto H, 1992, FK224, a novel cyclopeptide substance P antagonist with NK1 and NK2 receptor selectivity, J Pharmacol Exp Ther, 262, 398",{},{"id":24,"text":3117,"url":24,"identifiers":3118},"10.1016\u002F0024-3205(69)90099-X",{"doi":3117},{"id":24,"text":3120,"url":24,"identifiers":3121},"10.1046\u002Fj.1365-2249.2002.02003.x",{"doi":3120},{"id":24,"text":3123,"url":24,"identifiers":3124},"10.1016\u002FS0165-2478(99)00143-1",{"doi":3123},{"id":24,"text":3126,"url":24,"identifiers":3127},"10.1084\u002Fjem.181.3.845",{"doi":3126},{"id":24,"text":3129,"url":24,"identifiers":3130},"10.1111\u002Fj.1476-5381.1991.tb12164.x",{"doi":3129},{"id":24,"text":3132,"url":24,"identifiers":3133},"10.1046\u002Fj.1365-2222.1999.00010.x",{"doi":3132},{"id":24,"text":3135,"url":24,"identifiers":3136},"Adamko DJ, 1999, Ovalbumin sensitization changes the inflammatory responses to subsequent parainfluenza infection, eosinophils mediate airway hyperresponsiveness, M2 muscarinic receptor dysfunction, and antiviral effects, 190, 1465",{},{"id":24,"text":3138,"url":24,"identifiers":3139},"10.1093\u002Fnar\u002F26.23.5327",{"doi":3138},{"id":24,"text":3141,"url":24,"identifiers":3142},"10.1111\u002Fj.1365-2222.1990.tb02474.x",{"doi":3141},{"id":24,"text":3144,"url":24,"identifiers":3145},"10.1016\u002F0091-6749(92)90067-C",{"doi":3144},{"id":24,"text":3147,"url":24,"identifiers":3148},"10.1002\u002Fjlb.58.4.373",{"doi":3147},{"id":24,"text":3150,"url":24,"identifiers":3151},"10.1152\u002Fajplung.1999.277.4.L831",{"doi":3150},{"id":24,"text":3153,"url":24,"identifiers":3154},"10.1165\u002Fajrcmb.24.2.4264",{"doi":3153},{"id":24,"text":3156,"url":24,"identifiers":3157},"10.1016\u002FS0165-5728(02)00169-8",{"doi":3156},{"id":24,"text":3159,"url":24,"identifiers":3160},"10.1177\u002F000348949610500811",{"doi":3159},{"id":24,"text":3162,"url":24,"identifiers":3163},"10.1016\u002FS0194-5998(99)70061-6",{"doi":3162},{"id":24,"text":3165,"url":24,"identifiers":3166},"Okamoto Y, 1993, Cytokine expression after the topical administration of substance P to human nasal mucosa, J Immunol, 151, 4391, 10.4049\u002Fjimmunol.151.8.4391",{"doi":3167},"10.4049\u002Fjimmunol.151.8.4391",{"id":24,"text":3169,"url":24,"identifiers":3170},"Yamamoto S, 2004, Upregulation of IL‐4R by IFN‐γ, enhanced IL-4 induced eotaxin-3 production in airway epithelium",{},{"id":24,"text":3172,"url":24,"identifiers":3173},"10.1111\u002Fj.0019-2805.2004.01818.x",{"doi":3172},{"id":24,"text":3175,"url":24,"identifiers":3176},"10.1111\u002Fj.1365-2567.2004.01771.x",{"doi":3175}]