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M., 1994, Bio\u002FTechnology, 12, 674",{},{"id":24,"text":488,"url":24,"identifiers":505},{},{"id":24,"text":488,"url":24,"identifiers":507},{},{"id":24,"text":488,"url":24,"identifiers":509},{},{"id":24,"text":488,"url":24,"identifiers":511},{},{"id":24,"text":488,"url":24,"identifiers":513},{},{"id":24,"text":488,"url":24,"identifiers":515},{},{"id":24,"text":488,"url":24,"identifiers":517},{},{"id":24,"text":519,"url":24,"identifiers":520},"Mansfield E., 1981, Rev Econ Stat, 63, 610, 10.2307\u002F1935857",{"doi":521},"10.2307\u002F1935857",{"id":24,"text":488,"url":24,"identifiers":523},{},{"id":525,"createTime":526,"updateTime":527,"relativeEntities":528,"slug":529,"properties":530,"entityType":110,"verifyStatus":111,"verifyTime":526,"verifyNote":113,"languages":549,"translateLanguages":550,"viewCount":25,"primaryUrl":552,"fullTextUrl":24,"authors":553,"publicationType":293,"publisherRelationship":622,"citationCount":672,"citationInfo":673,"publishDate":679,"publishYear":674,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":680,"openAccess":24,"references":681,"isForceReanalyzing":352},"4bec7196-64d0-4503-97da-f0129fb1de58","2024-12-29T04:47:41.789+00:00","2025-02-22T22:15:49.047+00:00",[],"Pharmacokinetics-Safety-and-Tolerability-of-Tezepelumab-scp-AMG-scp-157-in-Healthy-and-Atopic-Dermatitis-Adult-Subjects",{"mag":531,"keywords":533,"pmc":535,"openalex":537,"abstract":539,"title":542,"pm":545,"doi":547},{"VOID":532},"2916779934",{"VI":534},"Tezepelumab, dược động học, độ an toàn, khả năng dung nạp, viêm da cơ địa.",{"VOID":536},"6766783",{"VOID":538},"W2916779934",{"EN":540,"VI":541},"\u003Cjats:p>Tezepelumab (\u003Cjats:styled-content style=\"fixed-case\">AMG\u003C\u002Fjats:styled-content> 157) is a monoclonal antibody that targets thymic stromal lymphopoietin and has shown benefits in treating asthma. We assessed the safety, tolerability, and pharmacokinetics of single‐ascending and multiple‐ascending doses in two randomized, double‐blind, placebo‐controlled phase I studies. Healthy and atopic dermatitis subjects were enrolled in the single‐dose study, and healthy subjects in the multiple‐dose study. Tezepelumab showed linear pharmacokinetics in both healthy and atopic dermatitis subjects. The half‐life after a subcutaneous or intravenous administration ranged from 19.9 to 25.7 days. After multiple doses, the mean area under the curve accumulation ratio was 1.82, 1.64, and 1.59 for the 35 mg, 105 mg, and 210 mg monthly subcutaneous doses, respectively. The mean maximum serum concentration (C\u003Cjats:sub>max\u003C\u002Fjats:sub>) accumulation ratio was 1.59, 2.84, and 6.74 for the 210 mg dose given every 28, 14, and 7 days, respectively. Tezepelumab was well tolerated in both studies with no evidence of immunogenicity.\u003C\u002Fjats:p>","\u003Cjats:p>Tezepelumab (\u003Cjats:styled-content style=\"fixed-case\">AMG\u003C\u002Fjats:styled-content> 157) là một kháng thể đơn dòng nhắm vào lymphopoietin khung tím và đã cho thấy lợi ích trong việc điều trị bệnh hen suyễn. Chúng tôi đã đánh giá độ an toàn, khả năng dung nạp và dược động học của các liều đơn gia tăng và liều nhiều gia tăng trong hai nghiên cứu giai đoạn I ngẫu nhiên, mù đôi, có đối chứng giả dược. Những đối tượng khỏe mạnh và bị viêm da cơ địa đã được tuyển vào nghiên cứu liều đơn, trong khi các đối tượng khỏe mạnh tham gia nghiên cứu liều nhiều. Tezepelumab cho thấy dược động học tuyến tính ở cả nhóm đối tượng khỏe mạnh và bị viêm da cơ địa. Thời gian bán hủy sau khi tiêm dưới da hoặc tiêm tĩnh mạch dao động từ 19.9 đến 25.7 ngày. Sau nhiều liều, tỷ lệ tích lũy diện tích dưới đường cong trung bình là 1.82, 1.64 và 1.59 cho các liều tiêm dưới da hàng tháng 35 mg, 105 mg và 210 mg, tương ứng. Tỷ lệ tích lũy nồng độ huyết thanh tối đa trung bình (C\u003Cjats:sub>max\u003C\u002Fjats:sub>) là 1.59, 2.84 và 6.74 cho liều 210 mg được dùng mỗi 28, 14 và 7 ngày, tương ứng. Tezepelumab được dung nạp tốt trong cả hai nghiên cứu mà không có bằng chứng về tính miễn dịch.",{"EN":543,"VI":544},"Pharmacokinetics, Safety, and Tolerability of Tezepelumab (\u003Cscp>AMG\u003C\u002Fscp> 157) in Healthy and Atopic Dermatitis Adult Subjects","Đặc điểm dược động học, độ an toàn và khả năng dung nạp của Tezepelumab (AMG 157) ở người trưởng thành khỏe mạnh và bị viêm da cơ địa",{"VOID":546},"30779339",{"VOID":548},"10.1002\u002Fcpt.1401",[115],[551],"VI","https:\u002F\u002Fascpt.onlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcpt.1401",[554,571,588,605],{"id":555,"sortIndex":25,"researcher":24,"roles":556,"affiliations":557,"properties":566},"242819e1-e1a8-46e3-87cb-3495d7eb4574",[],[558],{"id":559,"sortIndex":25,"affiliation":560,"properties":24},"a18e9e11-8062-4ea2-973b-a8d3ebfc2bab",{"id":559,"createTime":24,"updateTime":24,"relativeEntities":561,"slug":24,"properties":562,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":565,"statistic":24},[],{"title":563},{"VI":564},"Amgen, Inc., Thousand Oaks, California, USA",[],{"title":567,"openalex":569},{"EN":568},"Jane R. 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G., 1989, Grading of the severity of atopic dermatitis, Acta Derm. Venereol. Suppl. (Stockh.), 144, 13",{},{"id":24,"text":731,"url":24,"identifiers":732},"10.1034\u002Fj.1600-0625.2001.100102.x",{"doi":731},{"id":734,"createTime":735,"updateTime":736,"relativeEntities":737,"slug":738,"properties":739,"entityType":110,"verifyStatus":111,"verifyTime":755,"verifyNote":113,"languages":756,"translateLanguages":757,"viewCount":25,"primaryUrl":758,"fullTextUrl":24,"authors":759,"publicationType":293,"publisherRelationship":777,"citationCount":827,"citationInfo":828,"publishDate":838,"publishYear":829,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":839,"openAccess":24,"references":840,"isForceReanalyzing":352},"924fa8ec-ca8e-4039-8c56-71718050a8ca","2025-01-29T21:53:07.790+00:00","2025-02-22T22:14:51.136+00:00",[],"Thalidomide-in-the-treatment-of-lepra-reactions",{"mag":740,"keywords":742,"openalex":743,"abstract":745,"title":748,"pm":751,"doi":753},{"VOID":741},"2336461395",{"VI":488},{"VOID":744},"W2336461395",{"EN":746,"VI":747},"\u003Cjats:p>In 6 consecutive cases of lepromatous leprosy, acute severe lepra reactions were qUickly resolved with disappearance of symptoms as well as signs after the use of thalidomide as a sedative. No exceptions were noted. Concurrent therapy with sulfones and arsenicals did not appear to be involved. The cases are reported at this early stage because of the obvious importance of corroborating these findings.\u003C\u002Fjats:p>","\u003Cjats:p>Trong 6 trường hợp liên tiếp của bệnh phong thể bì, các phản ứng phong cấp tính nặng đã được giải quyết nhanh chóng với sự biến mất của các triệu chứng cũng như dấu hiệu sau khi sử dụng thalidomide như một loại thuốc an thần. Không có ngoại lệ nào được ghi nhận. Việc điều trị đồng thời với sulfones và arsenicals dường như không liên quan. Các trường hợp này được báo cáo ở giai đoạn sớm này vì tầm quan trọng rõ ràng trong việc xác nhận những phát hiện này.\u003C\u002Fjats:p>",{"EN":749,"VI":750},"Thalidomide in the treatment of lepra reactions","Thalidomide trong điều trị phản ứng phong",{"VOID":752},"14296027",{"VOID":754},"10.1002\u002Fcpt196563303","2025-01-29T21:53:07.789+00:00",[115],[551],"https:\u002F\u002Fascpt.onlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcpt196563303",[760],{"id":761,"sortIndex":25,"researcher":24,"roles":762,"affiliations":763,"properties":772},"fccc20f5-3541-4774-9b63-71794ce06144",[],[764],{"id":765,"sortIndex":25,"affiliation":766,"properties":24},"9f320a20-cca9-4462-912b-296c0fa07266",{"id":765,"createTime":24,"updateTime":24,"relativeEntities":767,"slug":24,"properties":768,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":771,"statistic":24},[],{"title":769},{"EN":770},"Government Hospital and Department of Dermatology, Rothschild Hadassah University Hospital, Jerusalem, Israel",[],{"title":773,"openalex":775},{"EN":774},"J Sheskin",{"VOID":776},"A5090947083",{"url":24,"publisher":778,"properties":820},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":779,"slug":10,"properties":780,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":785,"manageAffiliations":794,"indexDatabases":805,"url":90,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":781,"eissn":782,"issn":783,"title":784},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[786,790],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":787,"label":788,"description":789,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":791,"label":792,"description":793,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[795,800],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":796,"slug":24,"properties":797,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":799,"statistic":24},[],{"title":798},{"EN":45},[],{"id":48,"createTime":24,"updateTime":24,"relativeEntities":801,"slug":24,"properties":802,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":804,"statistic":24},[],{"title":803},{"EN":52},[],[806,813],{"id":56,"indexDatabase":807,"url":69,"indexYears":24,"academicFieldIds":812,"indexDatabaseRanking":24},{"id":58,"createTime":24,"updateTime":24,"relativeEntities":808,"label":809,"description":810,"key":65,"publicationTags":811,"standard":24},[],{"EN":61,"VI":61},{"EN":63,"VI":64},[67,68],[71],{"id":73,"indexDatabase":814,"url":84,"indexYears":85,"academicFieldIds":819,"indexDatabaseRanking":89},{"id":75,"createTime":24,"updateTime":24,"relativeEntities":815,"label":816,"description":817,"key":81,"publicationTags":818,"standard":24},[],{"EN":78,"VI":78},{"EN":78,"VI":80},[83],[87,88],{"issue":821,"pages":823,"volume":825},{"VOID":822},"3",{"VOID":824},"303-306",{"VOID":826},"6",526,{"total":827,"publishYear":829,"statisticByYear":830},1965,{"2012":831,"2013":832,"2014":449,"2015":832,"2016":833,"2017":834,"2018":835,"2019":831,"2020":834,"2021":834,"2022":836,"2023":837,"2024":677},11,14,23,17,13,18,20,"1965-05-01",[67,89],[],{"id":842,"createTime":843,"updateTime":843,"relativeEntities":844,"slug":845,"properties":846,"entityType":110,"verifyStatus":111,"verifyTime":843,"verifyNote":113,"languages":859,"translateLanguages":24,"viewCount":25,"primaryUrl":860,"fullTextUrl":24,"authors":861,"publicationType":293,"publisherRelationship":924,"citationCount":974,"citationInfo":975,"publishDate":978,"publishYear":976,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":979,"openAccess":24,"references":980,"isForceReanalyzing":352},"5a8decc0-fc33-4c17-911a-0752f63eef37","2025-02-10T05:33:10.317+00:00",[],"Effects-of-ticlopidine-a-new-platelet-aggregation-inhibitor-in-man",{"openalex":847,"mag":849,"abstract":851,"title":853,"pm":855,"doi":857},{"VOID":848},"W2341935027",{"VOID":850},"2341935027",{"EN":852},"\u003Cjats:p>Ticlopidine is a new platelet aggregation inhibitor. The effect of this drug was studied on 55 subjects, healthy volunteers and hospitalized patients. The action requires 24 to 48 hr to appear, and lasts more than 3 days. A dose‐effect relationship was studied with oral daily doses ranging from 250 to 1,000 mg during 1 wk; it showed a 50% inhibition on adenosine diphosphate (ADP )‐induced aggregation at 2 μM concentration on an oral daily dose of 450 mg. No action was found on collagen‐induced aggregation, and a mild effect was observed on platelet adhesiveness. 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