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2011, Guidelines for the management of inflammatory bowel disease in adults, Gut, 60, 571, 10.1136\u002Fgut.2010.224154\nEaden, 2001, The risk of colorectal cancer in ulcerative colitis: a meta-analysis, Gut, 48, 526, 10.1136\u002Fgut.48.4.526\nJawad, 2011, Inflammatory bowel disease and colon cancer, Recent Results Cancer Res, 185, 99, 10.1007\u002F978-3-642-03503-6_6\nKatsanos, 2011, Cancer in inflammatory bowel disease 15 years after diagnosis in a population-based European Collaborative follow-up study, J Crohns Colitis, 5, 430, 10.1016\u002Fj.crohns.2011.04.013\nHou, 2012, Risk of colorectal cancer among Caucasian and African American veterans with ulcerative colitis, Inflamm Bowel Dis, 18, 1011, 10.1002\u002Fibd.21840\nCanavan, 2006, Meta-analysis: colorectal and small bowel cancer risk in patients with Crohn's disease, Aliment Pharmacol Ther, 23, 1097, 10.1111\u002Fj.1365-2036.2006.02854.x\nLémann, 2006, Review article: can post-operative recurrence in Crohn's disease be 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Sydney: Department of Health, 2010.\nCosnes, 2005, Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery, Gut, 54, 237, 10.1136\u002Fgut.2004.045294\nRamadas, 2010, Natural history of Crohn's disease in a population-based cohort from Cardiff (1986-2003): a study of changes in medical treatment and surgical resection rates, Gut, 59, 1200, 10.1136\u002Fgut.2009.202101\nWinther, 2004, Long-term risk of cancer in ulcerative colitis: a population-based cohort study from Copenhagen County, Clin Gastroenterol Hepatol, 2, 1088, 10.1016\u002FS1542-3565(04)00543-9\nJess, 2006, Risk of intestinal cancer in inflammatory bowel disease: a population-based study from Olmsted county, Minnesota, Gastroenterology, 130, 1039, 10.1053\u002Fj.gastro.2005.12.037\nLakatos, 2006, Risk factors for ulcerative colitis-associated colorectal cancer in a Hungarian cohort of patients with ulcerative colitis: results of a population-based study, Inflamm Bowel Dis, 12, 205, 10.1097\u002F01.MIB.0000217770.21261.ce\nDoubeni, 2012, Socioeconomic status and the risk of colorectal cancer: an analysis of more than a half million adults in the National Institutes of Health-AARP Diet and Health Study, Cancer, 118, 3636, 10.1002\u002Fcncr.26677\nFarmer, 1993, Clinical patterns, natural history, and progression of ulcerative colitis: a long-term follow-up of 1116 patients, Dig Dis Sci, 38, 1137, 10.1007\u002FBF01295733\nLeijonmarck, 1990, Factors affecting colectomy rate in ulcerative colitis: an epidemiologic study, Gut, 31, 329, 10.1136\u002Fgut.31.3.329\nLangholz, 1992, Colorectal cancer risk and mortality in patients with ulcerative colitis, Gastroenterology, 103, 1444, 10.1016\u002F0016-5085(92)91163-X\nHöie, 2007, Ulcerative colitis: no rise in mortality in a European-wide population based cohort 10 years after diagnosis, Gut, 56, 497, 10.1136\u002Fgut.2006.101519\nHoie, 2007, Low colectomy rates in ulcerative colitis in an unselected European cohort followed for 10 years, Gastroenterology, 132, 507, 10.1053\u002Fj.gastro.2006.11.015\nKrishnaprasad, 2012, Inter-observer agreement for Crohn's disease sub-phenotypes using the Montreal Classification: how good are we? 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Issue date 2011-03. Siemens, Dimension Vista® System Flex® reagent cartridge. Siemens Healthcare Diagnostics Inc, Newark, DE.\nDaugherty, 1978, Bilirubin interference with the kinetic Jaffe method for serum creatinine, Clin Chem, 24, 392, 10.1093\u002Fclinchem\u002F24.2.392\nFiller, 2005, Cystatin C as a marker of GFR: history, indications, and future research, Clin Biochem, 38, 1, 10.1016\u002Fj.clinbiochem.2004.09.025\nFerguson, 2012, Established and emerging markers of kidney function, Clin Chem, 58, 680, 10.1373\u002Fclinchem.2011.167494\nVynckier, 2009, Urinary beta-trace protein as a new renal tubular marker, Clin Chem, 55, 1241, 10.1373\u002Fclinchem.2008.119727\nLeiper, 1999, Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases, Biochem J, 343, 209, 10.1042\u002Fbj3430209\nBode-Boger, 2006, Symmetrical dimethylarginine: a new combined parameter for renal function and extent of coronary artery disease, J Am Soc Nephrol, 17, 1128, 10.1681\u002FASN.2005101119\nStevens, 2008, Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD, Am J Kidney Dis, 51, 395, 10.1053\u002Fj.ajkd.2007.11.018\nSDMA-ELISA. 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Cholesterol In Adults (Adult Treatment Panel III), JAMA, 285, 2486, 10.1001\u002Fjama.285.19.2486\nMathiesen, 2002, Increased liver echogenicity at ultrasound examination reflects degree of steatosis but not of fibrosis in asymptomatic patients with mild\u002Fmoderate abnormalities of liver transaminases, Dig Liver Dis, 34, 516, 10.1016\u002FS1590-8658(02)80111-6\nHsu, 2019, Magnetic resonance vs transient elastography analysis of patients with nonalcoholic fatty liver disease: a systematic review and pooled analysis of individual participants, Clin Gastroenterol Hepatol, 17, 630, 10.1016\u002Fj.cgh.2018.05.059\nWai-Sun Wong, 2021, On the proposed definition of metabolic-associated fatty liver disease, Clin Gastroenterol Hepatol, 19, 865, 10.1016\u002Fj.cgh.2021.01.017\nLee, 2021, Metabolic dysfunction–associated fatty liver disease and incident cardiovascular disease risk: a nationwide cohort study, Clin Gastroenterol Hepatol, 19, 2138, 10.1016\u002Fj.cgh.2020.12.022\nBataller, 2005, 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fatty liver disease, Hepatology, 55, 77, 10.1002\u002Fhep.24706\nWai-Sun Wong, 2021, Impact of the new definition of metabolic associated fatty liver disease on the epidemiology of the disease, Clin Gastroenterol Hepatol, 19, 2161, 10.1016\u002Fj.cgh.2020.10.046\nYun, 2019, Fecal and blood microbiota profiles and presence of nonalcoholic fatty liver disease in obese versus lean subjects, PLoS One, 14, 10.1371\u002Fjournal.pone.0213692\nWei, 2015, Prevalence and severity of nonalcoholic fatty liver disease in non-obese patients: a population study using proton-magnetic resonance spectroscopy, Am J Gastroenterol, 110, 1306, 10.1038\u002Fajg.2015.235\nPark, 2021, Liver stiffness by magnetic resonance elastography is associated with increased risk of cardiovascular disease in patients with non-alcoholic fatty liver disease, Aliment Pharmacol Ther, 53, 1030, 10.1111\u002Fapt.16324\nAjmera, 2020, Clinical utility of an increase in magnetic resonance elastography in predicting fibrosis 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An epidemiological study in Orebro, Sweden, 1993-1998, Gut, 53, 346, 10.1136\u002Fgut.2003.014431\nFernandez-Banares, 1999, Incidence of collagenous and lymphocytic colitis: a 5-year population-based study, Am J Gastroenterol, 94, 418, 10.1016\u002FS0002-9270(98)00751-5\nWilliams, 2008, Microscopic colitis-defining incidence rates and risk factors: a population-based study, Clin Gastroenterol Hepatol, 6, 35, 10.1016\u002Fj.cgh.2007.10.031\nFernandez-Banares, 2011, Evolution of the incidence of collagenous colitis and lymphocytic colitis in Terrassa, Spain: a population-based study, Inflamm Bowel Dis, 17, 1015, 10.1002\u002Fibd.21438\nGuagnozzi, 2012, Prevalence and incidence of microscopic colitis in patients with diarrhoea of unknown aetiology in a region in central Spain, Dig Liver Dis, 44, 384, 10.1016\u002Fj.dld.2011.12.017\nVigren, 2012, An epidemiological study of collagenous colitis in southern Sweden from 2001-2010, World J Gastroenterol, 18, 2821, 10.3748\u002Fwjg.v18.i22.2821\nHowden LM, Meyer JA. 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Prescribing information. Foster City, CA: Gilead Sciences, 2015.\n2016\n2017\n2017, EASL. Recommendations on treatment of hepatitis C 2016, J Hepatol, 66, 153, 10.1016\u002Fj.jhep.2016.09.001\nNg, 2017, In vitro antiviral activity and resistance profile of the next generation hepatitis C virus NS5A inhibitor pibrentasvir, Antimicrob Agents Chemother, 61, 10.1128\u002FAAC.02558-16\nKwo, 2017, Glecaprevir and pibrentasvir yield high response rates in patients with HCV genotype 1-6 without cirrhosis, J Hepatol, 67, 263, 10.1016\u002Fj.jhep.2017.03.039\nWestfall, 2001, Optimally weighted, fixed sequence and gatekeeper multiple testing procedures, J Stat Plan Inference, 99, 25, 10.1016\u002FS0378-3758(01)00077-5\nSchinazi, 2017, From HCV to HBV cure, Liver Int, 37, 73, 10.1111\u002Fliv.13324\nKwo, 2011, The therapeutic approaches for hepatitis C virus: protease inhibitors and polymerase inhibitors, Gut Liver, 5, 406, 10.5009\u002Fgnl.2011.5.4.406\nChae, 2013, Direct-acting antivirals for the treatment of chronic hepatitis C: open issues and future perspectives, Scientific World Journal, 2013, 704912, 10.1155\u002F2013\u002F704912\nBanerjee, 2016, Review article: safety and tolerability of direct-acting anti-viral agents in the new era of hepatitis C therapy, Aliment Pharmacol Ther, 43, 674, 10.1111\u002Fapt.13514\n2015, Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus, Hepatology, 62, 932, 10.1002\u002Fhep.27950\nFoster, 2015, Sofosbuvir and velpatasvir for HCV genotype 2 and 3 infection, N Engl J Med, 373, 2608, 10.1056\u002FNEJMoa1512612\nFeld, 2015, Sofosbuvir and velpatasvir for HCV genotype 1, 2, 4, 5, and 6 infection, N Engl J Med, 373, 2599, 10.1056\u002FNEJMoa1512610\nJacobson, 2017, Efficacy of 8 weeks of sofosbuvir, velpatasvir, and voxilaprevir in patients with chronic HCV infection: 2 phase 3 randomized trials, Gastroenterology, 153, 113, 10.1053\u002Fj.gastro.2017.03.047\n2017\n2017\nCheng, 2016, In vitro antiviral activity and resistance profile characterization of the hepatitis C virus NS5A inhibitor ledipasvir, Antimicrob Agents Chemother, 60, 1847, 10.1128\u002FAAC.02524-15\nWang, 2014, Comparison of daclatasvir resistance barriers on NS5A from hepatitis C virus genotypes 1 to 6: implications for cross-genotype activity, Antimicrob Agents Chemother, 58, 5155, 10.1128\u002FAAC.02788-14\nKwo, 2017, High SVR rates upon 8- or 12-week treatment with glecaprevir and pibrentasvir in patients with chronic HCV genotype 1-6 infection without cirrhosis, J Hepatol, 67, 263, 10.1016\u002Fj.jhep.2017.03.039\nZeuzem S, Feld J, Wang S, et al. ENDURANCE-1: efficacy and safety of 8- versus 12-week treatment with ABT-493\u002FABT-530 in patients with chronic HCV genotype 1 infection. The Liver Meeting, Boston, MA, 2016.\nNg, 2016, Analysis of HCV variants in the MAGELLAN-I study (part 1): ABT-493 and ABT-530 combination therapy of genotype 1-infected patients who had failed prior direct acting antiviral-containing regimens, Hepatology, 64, 417A\nMuir, 2016, High SVR rates with ABT-493 + ABT-530 co-administered for 8 weeks in non-cirrhotic patients with HCV genotype 3 infection, Hepatology, 64, 183\nForns, 2017, Glecaprevir plus pibrentasvir for chronic hepatitis C virus genotype 1, 2, 4, 5, or 6 infection in adults with compensated cirrhosis (EXPEDITION-1): a single-arm, open-label, multicentre phase 3 trial, Lancet Infectious Diseases, 17, 1062, 10.1016\u002FS1473-3099(17)30496-6\nPuoti M, Foster G, Wang S, et al. 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liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease, Hepatology, 60, 565, 10.1002\u002Fhep.27173\nEkstedt, 2006, Long-term follow-up of patients with NAFLD and elevated liver enzymes, Hepatology, 44, 865, 10.1002\u002Fhep.21327\nSterne, 2009, Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls, BMJ, 338, b2393, 10.1136\u002Fbmj.b2393\nAngulo, 2007, The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD, Hepatology, 45, 846, 10.1002\u002Fhep.21496\nHarrison, 2008, Development and validation of a simple NAFLD clinical scoring system for identifying patients without advanced disease, Gut, 57, 1441, 10.1136\u002Fgut.2007.146019\nSterling, 2006, Development of a simple noninvasive index to predict significant fibrosis in patients with HIV\u002FHCV coinfection, Hepatology, 43, 1317, 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