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Glioblastoma remodelling of human neural circuits decreases survival. Nature. 2023;617(7961):599–607.\nde Godoy L, Chawla S, Brem S, Wang S, O'Rourke D, Nasrallah M, et al. Assessment of treatment response to dendritic cell vaccine in patients with glioblastoma using a multiparametric mri-based prediction model. J Neurooncol. 2023;163(1):173–83.\nDeng Z, Wu W, Wang N, Arafat W, Li Z, Wang J, et al. Emergency glioma resection but not hours of operation predicts perioperative complications: a single center study. Clin Neurol Neurosurg. 2019;182:11–6.\nZhang Q, Wu H, Zhang J, Qi Q, Zhang W, Xia R. Preoperative immune response is associated with perioperative transfusion requirements in glioma surgery. J Cancer. 2019;10:3526–32.\nCohen JA, Alan N, Seicean A, Weil RJ. Risk associated with perioperative red blood cell transfusion in cranial surgery. Neurosurg Rev. 2017;40:633–42.\nYin YH, Li CQ, Liu Z. Blood donation in China: sustaining efforts and challenges in achieving safety and availability. Transfusion. 2015;55:2523–30.\nAllain JP. Current approaches to increase blood donations in resource-limited countries. Transfus Med. 2019;29:297–310.\nJarnagin WR, Gonen M, Maithel SK, Fong Y, D’Angelica MI, Dematteo RP, et al. A prospective randomized trial of acute normovolemic hemodilution compared to standard intraoperative management in patients undergoing major hepatic resection. Ann Surg. 2008;248:360–9.\nFrietsch T, Steinbicker AU, Hackbusch M, Nguyen XD, Dietrich G. Safety of cell salvage in tumor surgery: systematic review with meta-analysis. Anaesthesist. 2020;69:331–51.\nMing Y, Zhang F, Yao Y, Cheng Z, Yu L, Sun D, et al. Large volume acute normovolemic hemodilution in patients undergoing cardiac surgery with intermediate-high risk of transfusion: a randomized controlled trial. J Clin Anesth. 2023;87: 111082.\nSpahn DR, Casutt M. Eliminating blood transfusions: new aspects and perspectives. Anesthesiology. 2000;93:242–55.\nSanders G, Mellor N, Rickards K, Rushton A, Christie I, Nicholl J, et al. Prospective randomized controlled trial of acute normovolaemic haemodilution in major gastrointestinal surgery. Br J Anaesth. 2004;93:775–81.\nZhou ZF, Jia XP, Sun K, Zhang FJ, Yu LN, Xing T, et al. Mild volume acute normovolemic hemodilution is associated with lower intraoperative transfusion and postoperative pulmonary infection in patients undergoing cardiac surgery – a retrospective, propensity matching study. BMC Anesthesiol. 2017;17:13.\nWeller M, van den Bent M, Tonn JC, Stupp R, Preusser M, Cohen-Jonathan-Moyal E, et al. European association for neuro-oncology (eano) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas. Lancet Oncol. 2017;18:e315–29.\nAmerican Society of Anesthesiologists Task Force on Perioperative Blood T, Adjuvant T. Practice guidelines for perioperative blood transfusion and adjuvant therapies: an updated report by the american society of anesthesiologists task force on perioperative blood transfusion and adjuvant therapies. Anesthesiology. 2006;105:198–208\nKrieg SM, Shiban E, Droese D, Gempt J, Buchmann N, Pape H, et al. Predictive value and safety of intraoperative neurophysiological monitoring with motor evoked potentials in glioma surgery. Neurosurgery. 2012;70:1060–1070; discussion 1070–1061\nDelaney M, Wendel S, Bercovitz RS, Cid J, Cohn C, Dunbar NM, et al. Transfusion reactions: prevention, diagnosis, and treatment. Lancet. 2016;388:2825–36.\nKusudo E, Murata Y, Matsumoto T, Kawamoto S, Egi M. Platelet function of whole blood after short-term cold storage: a prospective in vitro observational study. Transfusion. 2023;63:384–92.\nZhou J. A review of the application of autologous blood transfusion. Braz J Med Biol Res. 2016;49: e5493.\nCrescini WM, Muralidaran A, Shen I, LeBlan A, You J, Giacomuzzi C, et al. The use of acute normovolemic hemodilution in paediatric cardiac surgery. Acta Anaesthesiol Scand. 2018;62:756–64.\nTanner EJ, Filippova OT, Gardner GJ, Long Roche KC, Sonoda Y, Zivanovic O, et al. A prospective trial of acute normovolemic hemodilution in patients undergoing primary cytoreductive surgery for advanced ovarian cancer. Gynecol Oncol. 2018;151:433–7.\nOppitz PP, Stefani MA. Acute normovolemic hemodilution is safe in neurosurgery. World Neurosurg. 2013;79:719–24.\nDaif AA, Hassan YM, Ghareeb NA, Othman MM, Mohamed SA. Cerebral effect of acute normovolemic hemodilution during brain tumor resection. J Neurosurg Anesthesiol. 2012;24:19–24.\nSung CH, Tsuang FY, Shih CC, Chang JL, Liao MH, Yang YW, et al. Scalp block is associated with improved recurrence profiles in patients undergoing primary glioma resection surgery. J Neurosurg Anesthesiol. 2021;33(3):239–46.\nGe YL, Lv R, Zhou W, Ma XX, Zhong TD, Duan ML. Brain damage following severe acute normovolemic hemodilution in combination with controlled hypotension in rats. Acta Anaesthesiol Scand. 2007;51:1331–7.\nNi Y, Xu ZJ, Zhang ZF, Yang C, Liu CM, Gui B. Acute normovolemic hemodilution for major cancer surgeries during the COVID-19 pandemic: a beacon of hope. J Clin Anesth. 2020;65: 109871.\nCheong SH, Lee JH, Lee KM, Cho KR, Yang YI, Seo JY, et al. The effects of hemodilution on acute inflammatory responses in a bleomycin-induced lung injury model. Exp Lung Res. 2009;35:841–57.",{"EN":112},"Acute normovolemic hemodilution (ANH) was first introduced in glioblastoma surgery, and its role in reducing allogeneic blood transfusion was investigated in this study. This study enrolled supratentorial glioblastoma patients who received total resection. In the ANH group, the patients were required to draw blood before the operation, and the blood will be transfused back to the patient during the operation. The association between ANH and clinical features was investigated. Sixty supratentorial glioblastoma patients were enrolled in this study, 25 patients were allocated in the ANH group, and another 35 patients were included in the control group. ANH dramatically reduced the need for allogeneic blood transfusion (3 [12%] vs 12 [34.3%], P = 0.049), and the blood transfusion per total of patients was dramatically decreased by the application of ANH (0.40 ± 1.15 units vs 1.06 ± 1.59 units, P = 0.069). Furthermore, ANH also markedly reduced the requirement of fresh frozen plasma (FFP) transfusion (2 [8%] vs 11 [31.4%], P = 0.030) and the volume of FFP transfusion per total of patients (32.00 ± 114.46 mL vs 115.71 ± 181.00 mL, P = 0.033). The complication rate was similar between the two groups. 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Haq T, Yaqoob J, Munir K, Usman MU. Endovascular-covered stent treatment of posttraumatic cervical carotid artery pseudoaneurysms. Australas Radiol. 2004;48:220–3.",{"doi":468},"10.1111\u002Fj.1440-1673.2004.01302.x",{"id":20,"text":470,"url":20,"identifiers":471},"Mussa FF, Towfigh S, Rowe VL, Major K, Hood DB. Current trends in the management of iatrogenic cervical carotid artery injuries. Vasc Endovasc Surg. 2006;40:354–61.",{"doi":472},"10.1177\u002F1538574406290844",{"id":20,"text":474,"url":20,"identifiers":475},"Cothren CC, Moore EE, Biffl WL, Ciesla DJ, Ray CE. Anticoagulation is the gold standard therapy for blunt carotid injuries to reduce stroke rate. Arch Surg. 2004;139:540–5.",{"doi":476},"10.1001\u002Farchsurg.139.5.540",{"id":20,"text":478,"url":20,"identifiers":479},"Redekop G, Marotta T, Weill A. Treatment of traumatic aneurysms and arteriovenous fistulas of the skull base by using endovascular stents. J Neurosurg. 2001;95:412–9.",{"doi":480},"10.3171\u002Fjns.2001.95.3.0412",{"id":20,"text":482,"url":20,"identifiers":483},"Scavee V, De Wispelaere JF, Mormont E, Coulier B, Triqaux JP. Pseudoaneurysm of the internal carotid artery: treatment with a covered stent. Cardiovasc Intervent Radiol. 2001;24:283–5.",{"doi":484},"10.1007\u002Fs00270-001-0012-z",{"id":20,"text":486,"url":20,"identifiers":487},"Loffroy R, Gergele F, Rao P, Geschwind JF. Endovascular management of a posttraumatic pseudoaneurysm of the common carotid artery with superselective coil embolization. J Vasc Surg. 2011;53:1119–20.",{"doi":488},"10.1016\u002Fj.jvs.2010.02.026",{"id":20,"text":490,"url":20,"identifiers":491},"Doudle MW, Raptis S. Traumatic aneurysms of the carotid arteries. Aust N Z J Surg. 1996;66:847–9.",{"doi":492},"10.1111\u002Fj.1445-2197.1996.tb00768.x",{"id":20,"text":494,"url":20,"identifiers":495},"Schneider JR, Droste JS, Schindler N, Golan JF, Bernstein LP. Carotid endarterectomy with routine electroencephalography and selective shunting: influence of contralateral internal carotid artery occlusion and utility in prevention of perioperative strokes. J Vasc Surg. 2002;35:1114–22.",{"doi":496},"10.1067\u002Fmva.2002.124376",{"id":20,"text":498,"url":20,"identifiers":499},"Woodworth GF, McGirt MJ. Than KD, Huang J, Perler BA. Selective versus routine intraoperative shunting during carotid endarterectomy: a multivariate outcome analysis. Neurosurgery. 2007;61:1170–6.",{"doi":500},"10.1227\u002F01.neu.0000306094.15270.40",{"id":20,"text":502,"url":20,"identifiers":503},"Tan TW, Garcia-Toca M, Marcaccio EJ, Carney WI, Machan JT. Predictors of shunt during carotid endarterectomy with routine electroencephalography monitoring. J Vasc Surg. 2009;49:1374–8.",{"doi":504},"10.1016\u002Fj.jvs.2009.02.206",{"id":20,"text":506,"url":20,"identifiers":507},"Xu M, Wen J, Zhu X, Chen P, Wang C. A rare self-injurious case of multiple penetrating brain injury by nails in a young patient with depressive disorder. Acta Neurol Belg. 2015;115:767–9.",{"doi":508},"10.1007\u002Fs13760-015-0439-7",{"id":20,"text":510,"url":20,"identifiers":511},"Hussain M, Bari ME. Sucide bomb attack causing penetrating craniocerebral injury. Chin J Traumatol. 2013;16:51–3.",{},{"id":20,"text":513,"url":20,"identifiers":514},"Eder F, Meyer F, Huth C, Halloul Z, Lippert H. Penetrating abdomino-thoracic injuries:report of four imprecsive, spectacular and representative cases as well as their surgical management. Pol Przegl Chir. 2011;83:117–22.",{"doi":515},"10.2478\u002Fv10035-011-0019-3",{"id":517,"createTime":518,"updateTime":519,"relativeEntities":520,"slug":521,"properties":522,"entityType":117,"verifyStatus":318,"verifyTime":519,"verifyNote":319,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":531,"fullTextUrl":20,"authors":532,"publicationType":270,"publisherRelationship":608,"citationCount":20,"citationInfo":20,"publishDate":635,"publishYear":636,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":20,"isForceReanalyzing":300},"9f4ac8fc-6813-4316-b19d-f19405080549","2024-02-11T06:49:28.129+00:00","2025-02-20T23:39:18.567+00:00",[],"Hypoperfusion-assessed-by-pressure-reactivity-index-is-associated-with-delayed-cerebral-ischemia-after-subarachnoid-hemorrhage-an-observational-study",{"references":523,"abstract":525,"title":527,"doi":529},{"VOID":524},"Peterson EC, Wang Z, Britz G. Regulation of cerebral blood flow. Int J Vasc Med. 2011;2011:823525.\nCzosnyka M, Smielewski P, Kirkpatrick P, Laing RJ, Menon D, Pickard JD. Continuous assessment of the cerebral vasomotor reactivity in head injury. Neurosurgery. 1997;41(1):11–7 discussion 17-19.\nCzosnyka M, Smielewski P, Kirkpatrick P, Piechnik S, Laing R, Pickard JD. Continuous monitoring of cerebrovascular pressure-reactivity in head injury. Acta Neurochir Suppl. 1998;71:74–7.\nSteiner LA, Czosnyka M, Piechnik SK, Smielewski P, Chatfield D, Menon DK, Pickard JD. Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic brain injury. Crit Care Med. 2002;30(4):733–8.\nAries MJ, Czosnyka M, Budohoski KP, Steiner LA, Lavinio A, Kolias AG, Hutchinson PJ, Brady KM, Menon DK, Pickard JD, et al. Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury. Crit Care Med. 2012;40(8):2456–63.\nDias C, Silva MJ, Pereira E, Monteiro E, Maia I, Barbosa S, Silva S, Honrado T, Cerejo A, Aries MJ, et al. Optimal cerebral perfusion pressure management at bedside: a single-center pilot study. Neurocrit Care. 2015;23(1):92–102.\nRowland MJ, Hadjipavlou G, Kelly M, Westbrook J, Pattinson KT. Delayed cerebral ischaemia after subarachnoid haemorrhage: looking beyond vasospasm. Br J Anaesth. 2012;109(3):315–29.\nVergouwen MD, Vermeulen M, van Gijn J, Rinkel GJ, Wijdicks EF, Muizelaar JP, Mendelow AD, Juvela S, Yonas H, Terbrugge KG, et al. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. Stroke. 2010;41(10):2391–5.\nEide PK, Sorteberg A, Bentsen G, Marthinsen PB, Stubhaug A, Sorteberg W. Pressure-derived versus pressure wave amplitude-derived indices of cerebrovascular pressure reactivity in relation to early clinical state and 12-month outcome following aneurysmal subarachnoid hemorrhage. J Neurosurg. 2012;116(5):961–71.\nJaeger M, Schuhmann MU, Soehle M, Nagel C, Meixensberger J. Continuous monitoring of cerebrovascular autoregulation after subarachnoid hemorrhage by brain tissue oxygen pressure reactivity and its relation to delayed cerebral infarction. Stroke. 2007;38(3):981–6.\nJaeger M, Soehle M, Schuhmann MU, Meixensberger J. Clinical significance of impaired cerebrovascular autoregulation after severe aneurysmal subarachnoid hemorrhage. Stroke. 2012;43(8):2097–101.\nBudohoski KP, Czosnyka M, Kirkpatrick PJ, Smielewski P, Steiner LA, Pickard JD. Clinical relevance of cerebral autoregulation following subarachnoid haemorrhage. Nat Rev Neurol. 2013;9(3):152–63.\nRyttlefors M, Howells T, Nilsson P, Ronne-Engstrom E, Enblad P. Secondary insults in subarachnoid hemorrhage: occurrence and impact on outcome and clinical deterioration. Neurosurgery. 2007;61(4):704–14 discussion 714-705.\nWu X, Gao G, Feng J, Mao Q, Jiang J. A detailed protocol for physiological parameters acquisition and analysis in neurosurgical critical patients. J Vis Exp. 2017;128:56388. https:\u002F\u002Fdoi.org\u002F10.3791\u002F56388.\nDepreitere B, Guiza F, Van den Berghe G, Schuhmann MU, Maier G, Piper I, Meyfroidt G. Pressure autoregulation monitoring and cerebral perfusion pressure target recommendation in patients with severe traumatic brain injury based on minute-by-minute monitoring data. J Neurosurg. 2014;120(6):1451–7.\nKim H, Lee HJ, Kim YT, Son Y, Smielewski P, Czosnyka M, Kim DJ. Novel index for predicting mortality during the first 24 hours after traumatic brain injury. J Neurosurg. 2018;131(6):1887–95. https:\u002F\u002Fdoi.org\u002F10.3171\u002F2018.7.JNS18995.\nSorrentino E, Diedler J, Kasprowicz M, Budohoski KP, Haubrich C, Smielewski P, Outtrim JG, Manktelow A, Hutchinson PJ, Pickard JD, et al. Critical thresholds for cerebrovascular reactivity after traumatic brain injury. Neurocrit Care. 2012;16(2):258–66.\nDonnelly J, Czosnyka M, Adams H, Robba C, Steiner LA, Cardim D, Cabella B, Liu X, Ercole A, Hutchinson PJ, et al. Individualizing thresholds of cerebral perfusion pressure using estimated limits of autoregulation. Crit Care Med. 2017;45(9):1464–71.\nFrontera JA, Claassen J, Schmidt JM, Wartenberg KE, Temes R, Connolly ES Jr, MacDonald RL, Mayer SA. Prediction of symptomatic vasospasm after subarachnoid hemorrhage: the modified fisher scale. Neurosurgery. 2006;59(1):21–7 discussion 21-27.\nEtminan N, Vergouwen MD, Ilodigwe D, Macdonald RL. Effect of pharmaceutical treatment on vasospasm, delayed cerebral ischemia, and clinical outcome in patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. J Cereb Blood Flow Metab. 2011;31(6):1443–51.\nMacdonald RL. Delayed neurological deterioration after subarachnoid haemorrhage. Nat Rev Neurol. 2014;10(1):44–58.\nWillie CK, Tzeng YC, Fisher JA, Ainslie PN. Integrative regulation of human brain blood flow. J Physiol. 2014;592(5):841–59.\nAvolio A, Kim MO, Adji A, Gangoda S, Avadhanam B, Tan I, Butlin M. Cerebral haemodynamics: effects of systemic arterial pulsatile function and hypertension. Curr Hypertens Rep. 2018;20(3):20.\nBijlenga P, Czosnyka M, Budohoski KP, Soehle M, Pickard JD, Kirkpatrick PJ. Smielewski P: \"Optimal cerebral perfusion pressure\" in poor grade patients after subarachnoid hemorrhage. Neurocrit Care. 2010;13(1):17–23.\nNornes H, Knutzen HB, Wikeby P. Cerebral arterial blood flow and aneurysm surgery. Part 2: Induced hypotension and autoregulatory capacity. J Neurosurg. 1977;47(6):819–27.\nDonnelly J, Czosnyka M, Adams H, Robba C, Steiner LA, Cardim D, Cabella B, Liu X, Ercole A, Hutchinson PJ, et al. Pressure reactivity-based optimal cerebral perfusion pressure in a traumatic brain injury cohort. Acta Neurochir Suppl. 2018;126:209–12.\nSvedung Wettervik T, Howells T, Enblad P, Lewen A. Temporal neurophysiological dynamics in traumatic brain injury: role of pressure reactivity and optimal cerebral perfusion pressure for predicting outcome. J Neurotrauma. 2019;36(11):1818–27.\nBudohoski KP, Czosnyka M, Smielewski P, Kasprowicz M, Helmy A, Bulters D, Pickard JD, Kirkpatrick PJ. Impairment of cerebral autoregulation predicts delayed cerebral ischemia after subarachnoid hemorrhage: a prospective observational study. Stroke. 2012;43(12):3230–7.\nTan CO. Defining the characteristic relationship between arterial pressure and cerebral flow. J Appl Physiol (1985). 2012;113(8):1194–200.\nDorhout Mees SM, Rinkel GJ, Feigin VL, Algra A, van den Bergh WM, Vermeulen M, van Gijn J. Calcium antagonists for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2007;3:CD000277.\nTzeng YC, Chan GS, Willie CK, Ainslie PN. Determinants of human cerebral pressure-flow velocity relationships: new insights from vascular modelling and Ca(2)(+) channel blockade. J Physiol. 2011;589(Pt 13):3263–74.\nTan CO, Hamner JW, Taylor JA. The role of myogenic mechanisms in human cerebrovascular regulation. J Physiol. 2013;591(20):5095–105.\nChoi HA, Ko SB, Chen H, Gilmore E, Carpenter AM, Lee D, Claassen J, Mayer SA, Schmidt JM, Lee K, et al. Acute effects of nimodipine on cerebral vasculature and brain metabolism in high grade subarachnoid hemorrhage patients. Neurocrit Care. 2012;16(3):363–7.",{"EN":526},"Dysfunction of cerebral autoregulation is one of the pathophysiological mechanisms that causes delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). Pressure reactivity index (PRx) have been confirmed to reflect the level of cerebral autoregulation and used to derive optimal cerebral perfusion pressure (CPPopt). The goal of this study is to explore the associations between autoregulation, CPPopt, PRx, and DCI. Continuous intracranial pressure (ICP), arterial blood pressure (ABP), and cerebral perfusion pressure (CPP) signals acquired from 61 aSAH patients were retrospectively analyzed. PRx was calculated and collected by Pneumatic computer system. The CPP at the lowest PRx was determined as the CPPopt. The duration of a hypoperfusion event (dHP) was defined as the cumulative time that the PRx was > 0.3 and the CPP was \u003CCPPopt. The duration of CPP more than 10 mmHg below CPPopt (ΔCPPopt \u003C − 10 mmHg) was also used to assess hypoperfusion. The percent of the time of hypoperfusion by dHP and ΔCPPopt \u003C − 10 mmHg (%dHP and %ΔCPPopt) were compared between DCI group and control group, utilizing univariate and multivariable logistic regression. It was the clinical prognosis at 3 months after hemorrhage that was assessed with the modified Rankin Scale, and logistic regression and ROC analysis were used for predictive power for unfavorable outcomes (mRs 3–5). Data from 52 patients were included in the final analysis of 61 patients. The mean %dHP in DCI was 29.23% and 10.66% in control. The mean %ΔCPPopt \u003C − 10 mmHg was 22.28%, and 5.90% in control. The %dHP (p \u003C 0.001) and the %ΔCPPopt \u003C − 10mmHg (p \u003C 0.001) was significantly longer in the DCI group. In multivariate logistic regression model, %ΔCPPopt \u003C− 10 mmHg (p \u003C 0.001) and %dHP (p \u003C 0.001) were independent risk factor for predicting DCI, and %ΔCPPopt \u003C− 10 mmHg (p = 0.010) and %dHP (p = 0.026) were independent risk factor for predicting unfavorable outcomes. The increase of duration of hypoperfusion events and duration of CPP below CPPopt over 10 mmHg, evaluated as time of lowered CPP, is highly indicative of DCI and unfavorable outcomes.",{"EN":528},"Hypoperfusion assessed by pressure reactivity index is associated with delayed cerebral ischemia after subarachnoid hemorrhage: an observational 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Neurosurgery. 2010;67(2):237–49. https:\u002F\u002Fdoi.org\u002F10.1227\u002F01.NEU.0000371727.71991.64 (discussion 50. Epub 2010\u002F06\u002F12. PubMed PMID: 20539250.).\nLawton MT, Spetzler RF. Surgical management of giant intracranial aneurysms: experience with 171 patients. Clin Neurosurg. 1995;42:245–66 (PubMed PMID: 8846596).\nWiebers DO, Whisnant JP, Huston J 3rd, Meissner I, Brown RD Jr, Piepgras DG, et al. Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet. 2003;362(9378):103–10. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fs0140-6736(03)13860-3 (Epub 2003\u002F07\u002F18. PubMed PMID: 12867109.).\nChoi IS, David C. Giant intracranial aneurysms: development, clinical presentation and treatment. Eur J Radiol. 2003;46(3):178–94. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fs0720-048x(03)00090-1 (Epub 2003\u002F05\u002F22. PubMed PMID: 12758113.).\nDrake CG. Giant intracranial aneurysms: experience with surgical treatment in 174 patients. Clin Neurosurg. 1979;26:12–95. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fneurosurgery\u002F26.cn_suppl_1.12 (Epub 1979\u002F01\u002F01. PubMed PMID: 544122.).\nSpetzler RF, McDougall CG, Zabramski JM, Albuquerque FC, Hills NK, Russin JJ, et al. The Barrow Ruptured Aneurysm Trial: 6-year results. J Neurosurg. 2015;123(3):609–17. https:\u002F\u002Fdoi.org\u002F10.3171\u002F2014.9.JNS141749 (Epub 2015\u002F06\u002F27. PubMed PMID: 26115467.).\nLi J, Lan ZG, Liu Y, He M, You C. Large and giant ventral paraclinoid carotid aneurysms: surgical techniques, complications and outcomes. Clin Neurol Neurosurg. 2012;114(7):907–13. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.clineuro.2012.01.039 (Epub 2012\u002F03\u002F01. PubMed PMID: 22361473.).\nDengler J, Maldaner N, Glasker S, Endres M, Wagner M, Malzahn U, et al. Outcome of surgical or endovascular treatment of giant intracranial aneurysms, with emphasis on age, aneurysm location, and unruptured aneuryms–a systematic review and meta-analysis. Cerebrovasc Dis. 2016;41(3–4):187–98. https:\u002F\u002Fdoi.org\u002F10.1159\u002F000443485 (Epub 2016\u002F01\u002F15. PubMed PMID: 26764969.).\nGonzalez NR, Duckwiler G, Jahan R, Murayama Y, Vinuela F. Challenges in the endovascular treatment of giant intracranial aneurysms. Neurosurgery. 2008;62(6 Suppl 3):1324–35. https:\u002F\u002Fdoi.org\u002F10.1227\u002F01.neu.0000333797.59585.c0 (Epub 2008\u002F08\u002F22. PubMed PMID: 18695552.).\nYan P, Zhang Y, Liang F, Ma C, Liang S, Guo F, et al. Comparison of safety and effectiveness of endovascular treatments for unruptured intracranial large or giant aneurysms in internal carotid artery. World Neurosurg. 2019;125:e385–91. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.wneu.2019.01.082 (Epub 2019\u002F02\u002F01. PubMed PMID: 30703601.).\nRaymond J, Guilbert F, Weill A, Georganos SA, Juravsky L, Lambert A, et al. Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils. Stroke. 2003;34(6):1398–403. https:\u002F\u002Fdoi.org\u002F10.1161\u002F01.STR.0000073841.88563.E9 (Epub 2003\u002F05\u002F31. PubMed PMID: 12775880.).\nFiorella D, Kelly ME, Albuquerque FC, Nelson PK. Curative reconstruction of a giant midbasilar trunk aneurysm with the pipeline embolization device. Neurosurgery. 2009;64(2):212–7. https:\u002F\u002Fdoi.org\u002F10.1227\u002F01.NEU.0000337576.98984.E4 (discussion 7. Epub 2008\u002F12\u002F06. PubMed PMID: 19057425.).\nYu SC, Kwok CK, Cheng PW, Chan KY, Lau SS, Lui WM, et al. Intracranial aneurysms: midterm outcome of pipeline embolization device–a prospective study in 143 patients with 178 aneurysms. Radiology. 2012;265(3):893–901. https:\u002F\u002Fdoi.org\u002F10.1148\u002Fradiol.12120422 (Epub 2012\u002F09\u002F22. PubMed PMID: 22996749.).\nHanel RA, Spetzler RF. Surgical treatment of complex intracranial aneurysms. Neurosurgery. 2008;62:1289–97. https:\u002F\u002Fdoi.org\u002F10.1227\u002F01.neu.0000333794.13844.d9 (Epub 2008\u002F08\u002F22. PubMed PMID: 18695549.).\nNordahl H, Osler M, Frederiksen BL, Andersen I, Prescott E, Overvad K, et al. Combined effects of socioeconomic position, smoking, and hypertension on risk of ischemic and hemorrhagic stroke. Stroke. 2014;45(9):2582–7. https:\u002F\u002Fdoi.org\u002F10.1161\u002FSTROKEAHA.114.005252 (Epub 2014\u002F08\u002F16. PubMed PMID: 25123220.).\nTeo KK, Ounpuu S, Hawken S, Pandey MR, Valentin V, Hunt D, et al. Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study. Lancet. 2006;368(9536):647–58. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0140-6736(06)69249-0 (Epub 2006\u002F08\u002F22. PubMed PMID: 16920470.).\nBrisman JL, Song JK, Newell DW. Cerebral aneurysms. N Engl J Med. 2006;355(9):928–39. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMra052760 (Epub 2006\u002F09\u002F01. PubMed PMID: 16943405.).",{"EN":911},"Giant intracranial aneurysms (GIAs) are challenges for surgical treatment. Risk factors of postoperative stroke remain unclear. This study aims to investigate the predictors of postoperative stroke in GIAs and the impact of stroke on outcomes. We performed a retrospective medical record review of patients with GIAs who received microsurgery at our institution between 2011 and 2018. Multivariate logistic regression analyses were carried out to identify risk factors for postoperative stroke. The clinical and angiographic outcomes were compared between patients with and without stroke. A total of 97 patients were included in this study. Surgical modalities included direct aneurysm neck clipping in 85 patients (87.7%), trapping with the bypass in 8 (8.2%), proximal artery ligation in 1 (1%), and bypass alone in 3 (3.1%). Postoperative stroke was found in 26 patients (26.8%). Independent factors that affect postoperative stroke were recurrent aneurysm (OR, 10.982; 95% CI, 1.976–61.045; P = 0.006) and size ≥ 3.5 cm (OR, 3.420; 95% CI, 1.133–10.327; P = 0.029). Combined perioperative mortality and morbidity was 26.8%. Follow-up was achieved from 89 patients (91.8%), with a mean follow-up period of 39 months (range 19 to 94 months). Good outcomes were observed in 75 patients (84.3%) and poor outcomes were observed in 14 patients (15.7%). Postoperative stroke was significantly associated with clinical outcome. Favorable outcomes can be achieved in most patients with GIAs after appropriate microsurgical modality. Recurrent aneurysm and size ≥ 3.5 cm are risk factors of postoperative stroke.",{"EN":913},"Risk factors and outcomes of postoperative stroke in surgical treatment for giant intracranial aneurysms",{"VOID":915},"10.1186\u002Fs41016-022-00297-x","https:\u002F\u002Fcnjournal.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs41016-022-00297-x",[918,933,945,957],{"id":919,"sortIndex":21,"researcher":20,"roles":920,"affiliations":921,"properties":930},"6bfa0085-fa01-4995-9dcd-3b31bee41f19",[123],[922],{"id":20,"sortIndex":21,"affiliation":923,"properties":20},{"id":924,"createTime":925,"updateTime":925,"relativeEntities":926,"slug":20,"properties":927,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"4eda95ce-b8b8-4dea-912f-03c7cb1f893b","2024-02-13T06:05:00.790+00:00",[],{"title":928},{"VI":929},"Department of Neurosurgery, Fengtai District, Beijing Tiantan Hospital, Capital Medical University, Beijing, China",{"title":931},{"VI":932},"Hao Wang",{"id":934,"sortIndex":172,"researcher":20,"roles":935,"affiliations":936,"properties":942},"338628d3-ffca-48da-bf7d-15c384e4ce8e",[123],[937],{"id":20,"sortIndex":21,"affiliation":938,"properties":20},{"id":924,"createTime":925,"updateTime":925,"relativeEntities":939,"slug":20,"properties":940,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":941},{"VI":929},{"title":943},{"VI":944},"Xin Chen",{"id":946,"sortIndex":93,"researcher":20,"roles":947,"affiliations":948,"properties":954},"ab05e43d-a0da-417c-ad96-62bee82e02e9",[123],[949],{"id":20,"sortIndex":21,"affiliation":950,"properties":20},{"id":924,"createTime":925,"updateTime":925,"relativeEntities":951,"slug":20,"properties":952,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":953},{"VI":929},{"title":955},{"VI":956},"Qiang Hao",{"id":958,"sortIndex":94,"researcher":20,"roles":959,"affiliations":960,"properties":971},"3e8fdeb8-a2e2-41f9-9374-7c76cce262a7",[123],[961],{"id":20,"sortIndex":21,"affiliation":962,"properties":20},{"id":963,"createTime":964,"updateTime":965,"relativeEntities":966,"slug":967,"properties":968,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"49952c28-b525-450c-8b12-d57cd1939e2f","2024-02-12T17:30:39.912+00:00","2024-10-05T07:19:57.621+00:00",[],"Department-of-Neurosurgery-West-China-Hospital-Sichuan-University-Chengdu-China",{"title":969},{"VI":970},"Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China",{"title":972},{"VI":973},"Junlin Lu",{"url":916,"publisher":975,"properties":996},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":976,"slug":10,"properties":977,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":981,"manageAffiliations":982,"indexDatabases":983,"url":20,"thumbnailPath":20,"statistic":991,"gsStatistic":20,"type":99,"analyzePriority":20},[],{"issn":978,"title":979,"url":980},{"VOID":13},{"EN":15},{"VOID":17},[],[],[984],{"id":62,"indexDatabase":985,"url":75,"indexYears":76,"academicFieldIds":990,"indexDatabaseRanking":81},{"id":64,"createTime":65,"updateTime":66,"relativeEntities":986,"label":987,"description":988,"key":72,"publicationTags":989,"standard":20},[],{"EN":69,"VI":69},{"EN":69,"VI":71},[74],[78,79,80],{"impactFactor":21,"impactFactorByYear":992,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":84,"totalPublicationByYear":993,"totalCitation":94,"totalCitationByYear":994,"totalCitationPerPublication":96,"totalCitationPerPublicationByYear":995,"hindexLast5Year":94,"hindex":94},{},{"2015":86,"2016":87,"2017":88,"2018":89,"2019":90,"2020":91,"2021":92,"2022":92,"2023":88,"2024":93},{"2015":94},{"2015":98},{"volume":997,"pages":999},{"VOID":998},"8",{"VOID":634},"2022-10-03",2022,{"id":1003,"createTime":1004,"updateTime":1004,"relativeEntities":1005,"slug":1006,"properties":1007,"entityType":117,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":1016,"translateLanguages":20,"viewCount":21,"primaryUrl":1017,"fullTextUrl":20,"authors":1018,"publicationType":270,"publisherRelationship":1113,"citationCount":20,"citationInfo":20,"publishDate":1135,"publishYear":1136,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":1137,"isForceReanalyzing":300},"55a51725-2e9d-43ea-bae3-d0658dc73ace","2024-04-09T23:27:49.902+00:00",[],"Sex-differences-in-traumatic-brain-injury-a-multi-dimensional-exploration-in-genes-hormones-cells-individuals-and-society",{"keywords":1008,"abstract":1010,"title":1012,"doi":1014},{"EN":1009},"",{"EN":1011},"Traumatic brain injury (TBI) is exceptionally prevalent in society and often imposes a massive burden on patients’ families and poor prognosis. The evidence reviewed here suggests that gender can influence clinical outcomes of TBI in many aspects, ranges from patients’ mortality and short-term outcome to their long-term outcome, as well as the incidence of cognitive impairment. We mainly focused on the causes and mechanisms underlying the differences between male and female after TBI, from both biological and sociological views. As it turns out that multiple factors contribute to the gender differences after TBI, not merely the perspective of gender and sex hormones. Centered on this, we discussed how female steroid hormones exert neuroprotective effects through the anti-inflammatory and antioxidant mechanism, along with the cognitive impairment and the social integration problems it caused. As to the treatment, both instant and long-term treatment of TBI requires adjustments according to gender. A further study with more focus on this topic is therefore suggested to provide better treatment options for these patients.",{"EN":1013},"Sex differences in traumatic brain injury: a multi-dimensional exploration in genes, hormones, cells, individuals, and society",{"VOID":1015},"10.1186\u002Fs41016-019-0173-8",[321],"https:\u002F\u002Fcnjournal.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs41016-019-0173-8",[1019,1036,1050,1062,1074,1089,1101],{"id":1020,"sortIndex":153,"researcher":20,"roles":1021,"affiliations":1022,"properties":1033},"2175eea9-5e7f-45b1-96be-840fa326a08f",[],[1023],{"id":20,"sortIndex":21,"affiliation":1024,"properties":20},{"id":1025,"createTime":1026,"updateTime":1027,"relativeEntities":1028,"slug":1029,"properties":1030,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"96627ec2-9aed-4e25-87b2-1559afc62e3e","2023-12-14T13:52:00.466+00:00","2024-10-01T09:55:04.353+00:00",[],"Department-of-Neurosurgery-Brain-and-Nerve-Research-Laboratory-The-First-Affiliated-Hospital-of-Soochow-University-Suzhou-China",{"title":1031},{"VI":1032},"Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China",{"title":1034},{"EN":1035},"Zhouqing Chen",{"id":1037,"sortIndex":751,"researcher":20,"roles":1038,"affiliations":1039,"properties":1045},"67863ce2-50d6-47b7-ad18-e1ecbd4c4e93",[],[1040],{"id":20,"sortIndex":21,"affiliation":1041,"properties":20},{"id":1025,"createTime":1026,"updateTime":1027,"relativeEntities":1042,"slug":1029,"properties":1043,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1044},{"VI":1032},{"title":1046,"email":1048},{"EN":1047},"Zhong 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Shen",{"id":1090,"sortIndex":93,"researcher":20,"roles":1091,"affiliations":1092,"properties":1098},"5c11a66d-0d12-4a75-9e19-32ff765f0103",[],[1093],{"id":20,"sortIndex":21,"affiliation":1094,"properties":20},{"id":1025,"createTime":1026,"updateTime":1027,"relativeEntities":1095,"slug":1029,"properties":1096,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1097},{"VI":1032},{"title":1099},{"EN":1100},"Yanbo 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Wu",{"url":20,"publisher":1114,"properties":20},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1115,"slug":10,"properties":1116,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1120,"manageAffiliations":1121,"indexDatabases":1122,"url":20,"thumbnailPath":20,"statistic":1130,"gsStatistic":20,"type":99,"analyzePriority":20},[],{"issn":1117,"title":1118,"url":1119},{"VOID":13},{"EN":15},{"VOID":17},[],[],[1123],{"id":62,"indexDatabase":1124,"url":75,"indexYears":76,"academicFieldIds":1129,"indexDatabaseRanking":81},{"id":64,"createTime":65,"updateTime":66,"relativeEntities":1125,"label":1126,"description":1127,"key":72,"publicationTags":1128,"standard":20},[],{"EN":69,"VI":69},{"EN":69,"VI":71},[74],[78,79,80],{"impactFactor":21,"impactFactorByYear":1131,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":84,"totalPublicationByYear":1132,"totalCitation":94,"totalCitationByYear":1133,"totalCitationPerPublication":96,"totalCitationPerPublicationByYear":1134,"hindexLast5Year":94,"hindex":94},{},{"2015":86,"2016":87,"2017":88,"2018":89,"2019":90,"2020":91,"2021":92,"2022":92,"2023":88,"2024":93},{"2015":94},{"2015":98},"2019-10-04",2019,[1138,1140,1142,1144,1146,1148,1150,1152,1154,1156,1158,1160,1162,1164,1166,1168,1170,1172,1174,1176,1178,1180,1182,1184,1186,1188,1190,1192,1194,1196,1198,1200,1202,1204,1206,1208,1210,1212,1214,1216,1218,1220,1222,1224,1226,1228,1230,1232,1234,1236,1238,1240,1242,1244,1246,1248,1250,1252,1254,1256,1258,1260,1262,1264,1266,1268,1270,1272,1274,1276,1278,1280,1282,1284,1286,1288,1290,1292,1294,1296,1298,1300,1302,1304,1306,1308,1310,1312,1314,1316,1318,1320,1322,1324,1326,1328,1330,1332,1334,1336,1338,1340,1342,1344,1346,1348,1350,1352,1354,1356,1358,1360,1362,1364,1366,1368,1370,1372,1374,1376,1378,1380,1382,1384,1386,1388,1390,1392,1394],{"id":20,"text":1139,"url":20,"identifiers":20},"Roozenbeek B, Maas AI, Menon DK. Changing patterns in the epidemiology of traumatic brain injury. Nat Rev Neurol. 2013;9(4):231–6.",{"id":20,"text":1141,"url":20,"identifiers":20},"Maas AI, Stocchetti N, Bullock R. Moderate and severe traumatic brain injury in adults. Lancet Neurol. 2008;7(8):728–41.",{"id":20,"text":1143,"url":20,"identifiers":20},"Peterson, A.B., et al., Surveillance report of traumatic brain injury-related emergency department visits, hospitalizations, and deaths, United States, 2014. 2019.",{"id":20,"text":1145,"url":20,"identifiers":20},"Tiret L, et al. The epidemiology of head trauma in Aquitaine (France), 1986: a community-based study of hospital admissions and deaths. Int J Epidemiol. 1990;19(1):133–40.",{"id":20,"text":1147,"url":20,"identifiers":20},"Egea-Guerrero JJ, et al. S100B protein may detect brain death development after severe traumatic brain injury. J Neurotrauma. 2013;30(20):1762–9.",{"id":20,"text":1149,"url":20,"identifiers":20},"Leitgeb J, et al. Effects of gender on outcomes after traumatic brain injury. J Trauma. 2011;71(6):1620–6.",{"id":20,"text":1151,"url":20,"identifiers":20},"Hirschberg R, Weiss D, Zafonte R. Traumatic brain injury and gender: what is known and what is not; 2008.",{"id":20,"text":1153,"url":20,"identifiers":20},"Wagner AK, et al. Relationships between cerebrospinal fluid markers of excitotoxicity, ischemia, and oxidative damage after severe TBI: the impact of gender, age, and hypothermia. J Neurotrauma. 2004;21(2):125–36.",{"id":20,"text":1155,"url":20,"identifiers":20},"Vagnerova K, Koerner IP, Hurn PD. Gender and the injured brain. Anesth Analg. 2008;107(1):201–14.",{"id":20,"text":1157,"url":20,"identifiers":20},"Bodhankar S, et al. Role for microglia in sex differences after ischemic stroke: importance of M2. Metab Brain Dis. 2015;30(6):1515–29.",{"id":20,"text":1159,"url":20,"identifiers":20},"Shahrokhi N, et al. 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J Comp Neurol. 1992;323(3):326–40.",{"id":20,"text":1169,"url":20,"identifiers":20},"Kulynych JJ, et al. Gender differences in the normal lateralization of the supratemporal cortex: MRI surface-rendering morphometry of Heschl’s gyrus and the planum temporale. Cereb Cortex. 1994;4(2):107–18.",{"id":20,"text":1171,"url":20,"identifiers":20},"Holloway RL, et al. Sexual dimorphism of the human corpus callosum from three independent samples: relative size of the corpus callosum. Am J Phys Anthropol. 1993;92(4):481–98.",{"id":20,"text":1173,"url":20,"identifiers":20},"Benbow CP. Sex-differences in mathematical reasoning ability in intellectually talented preadolescents - their nature, effects, and possible causes. Behav Brain Sci. 1988;11(2):169–83.",{"id":20,"text":1175,"url":20,"identifiers":20},"Bayir H, et al. Marked gender effect on lipid peroxidation after severe traumatic brain injury in adult patients. 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Crit Care Resusc. 2005;7(3):238.",{"id":1397,"createTime":1398,"updateTime":1399,"relativeEntities":1400,"slug":1401,"properties":1402,"entityType":117,"verifyStatus":318,"verifyTime":1399,"verifyNote":319,"syncStatus":19,"languages":1414,"translateLanguages":20,"viewCount":21,"primaryUrl":1415,"fullTextUrl":20,"authors":1416,"publicationType":270,"publisherRelationship":1509,"citationCount":172,"citationInfo":1531,"publishDate":20,"publishYear":20,"citationAnalyzeStatus":1533,"lastCitationAnalyze":1534,"indexDatabases":20,"openAccess":20,"references":1535,"isForceReanalyzing":300},"fca3c428-0b9d-4813-a930-4575b86fa591","2024-04-11T19:32:10.318+00:00","2025-02-06T23:23:28.903+00:00",[],"Primary-gliosarcoma-with-widespread-extracranial-metastases-spatiotemporal-morphological-variation",{"keywords":1403,"openalex":1404,"abstract":1406,"title":1408,"pm":1410,"doi":1412},{},{"VOID":1405},"W4289941721",{"EN":1407},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\n                \u003Cjats:title>Background\u003C\u002Fjats:title>\n                \u003Cjats:p>We summarize 5 cases of primary gliosarcoma with widespread extracranial metastases including our case. The glial components are eliminated due to the needs of the living environment in the process of parasitism and survival of brain glioma-sarcoma cells in lung metastasis.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>\u003Cjats:sec>\n                \u003Cjats:title>Methods\u003C\u002Fjats:title>\n                \u003Cjats:p>A PubMed search using the keywords “gliosarcoma” and “extracranial metastases” was performed followed by a review of cited literature. Our case was a 50-year-old female presented with headache and dizziness. MRI examination showed that there was a cystic solid tumor in the right temporal lobe. The tumor was removed totally. Seven months after the operation, the patient suffered recurrent intermittent headache. The resection for the recurrent tumor was performed. Postoperative pathology confirmed the recurrent gliosarcoma. A needle biopsy was performed for the nodular on the right lung. The lung tumor pathology suggested a sarcoma structure.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>\u003Cjats:sec>\n                \u003Cjats:title>Results\u003C\u002Fjats:title>\n                \u003Cjats:p>There was a female patient in five cases. The age range is 47 to 69 years old. The tumor recurred within a year. A combination of treatment modalities may extend survival; however, the prognosis remains poor.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>\u003Cjats:sec>\n                \u003Cjats:title>Conclusion\u003C\u002Fjats:title>\n                \u003Cjats:p>Primary gliosarcoma with extracranial metastases is extremely rare. Some findings uncovered an unexpected spatiotemporal morphological variation in the different foci of the same malignancy.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>",{"EN":1409},"Primary gliosarcoma with widespread extracranial metastases—spatiotemporal morphological variation",{"VOID":1411},"35932030",{"VOID":1413},"10.1186\u002Fs41016-022-00285-1",[321],"https:\u002F\u002Fcnjournal.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs41016-022-00285-1",[1417,1436,1456,1475,1489],{"id":1418,"sortIndex":153,"researcher":20,"roles":1419,"affiliations":1420,"properties":1429},"e811f9c0-ec95-4d75-91dd-3a1015a8ae78",[],[1421],{"id":20,"sortIndex":21,"affiliation":1422,"properties":20},{"id":1423,"createTime":1424,"updateTime":1424,"relativeEntities":1425,"slug":20,"properties":1426,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"3984b407-7e5a-4c7e-8376-289ea68d8e41","2023-12-06T14:53:25.662+00:00",[],{"title":1427},{"VI":1428},"Department of Pathology, Peking University Third Hospital, Beijing, China",{"openalex":1430,"orcid":1432,"title":1434},{"VOID":1431},"A5035768028",{"VOID":1433},"https:\u002F\u002Forcid.org\u002F0000-0002-2243-2301",{"EN":1435},"Xiaodong Chai",{"id":1437,"sortIndex":21,"researcher":20,"roles":1438,"affiliations":1439,"properties":1449},"b09f2467-65ef-4de6-9713-9cc725f321b5",[],[1440],{"id":20,"sortIndex":21,"affiliation":1441,"properties":20},{"id":1442,"createTime":1443,"updateTime":1443,"relativeEntities":1444,"slug":1445,"properties":1446,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"187d0ad4-6578-4019-a7bb-60e4fdb5f483","2024-04-11T19:32:11.063+00:00",[],"Medical-Imaging-Department-Third-Affiliated-Hospital-of-Baotou-Medical-College-Baotou-Inner-Mongolia-China",{"title":1447},{"EN":1448},"Medical Imaging Department, Third Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, China",{"openalex":1450,"orcid":1452,"title":1454},{"VOID":1451},"A5024493711",{"VOID":1453},"https:\u002F\u002Forcid.org\u002F0000-0002-9331-701X",{"EN":1455},"Ming Luo",{"id":1457,"sortIndex":94,"researcher":20,"roles":1458,"affiliations":1459,"properties":1468},"b82ac497-1e18-4690-948c-00f2e8ca2408",[],[1460],{"id":20,"sortIndex":21,"affiliation":1461,"properties":20},{"id":1462,"createTime":1463,"updateTime":1463,"relativeEntities":1464,"slug":20,"properties":1465,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"ab558d82-56bc-4305-9745-54cb317618db","2023-12-28T10:56:15.559+00:00",[],{"title":1466},{"VI":1467},"Department of Neurosurgery, Peking University Third hospital, Beijing, China",{"openalex":1469,"orcid":1471,"title":1473},{"VOID":1470},"A5061426227",{"VOID":1472},"https:\u002F\u002Forcid.org\u002F0000-0002-4233-3220",{"EN":1474},"Jun Yang",{"id":1476,"sortIndex":172,"researcher":20,"roles":1477,"affiliations":1478,"properties":1484},"36014950-b40b-4cc7-a537-f3aa773421fc",[],[1479],{"id":20,"sortIndex":21,"affiliation":1480,"properties":20},{"id":1462,"createTime":1463,"updateTime":1463,"relativeEntities":1481,"slug":20,"properties":1482,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1483},{"VI":1467},{"openalex":1485,"title":1487},{"VOID":1486},"A5012420517",{"EN":1488},"Jianjun Sun",{"id":1490,"sortIndex":93,"researcher":20,"roles":1491,"affiliations":1492,"properties":1502},"deacb790-e206-495e-b9da-ce4500fdb13b",[],[1493],{"id":20,"sortIndex":21,"affiliation":1494,"properties":20},{"id":1495,"createTime":1496,"updateTime":1496,"relativeEntities":1497,"slug":1498,"properties":1499,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"a036f74a-6407-4704-9cc7-601a8c1f3355","2024-04-11T19:32:11.148+00:00",[],"Department-of-Oncology-First-Affiliated-Hospital-of-Baotou-Medical-College-Baotou-Inner-Mongolia-China",{"title":1500},{"EN":1501},"Department of Oncology, First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, China",{"openalex":1503,"orcid":1505,"title":1507},{"VOID":1504},"A5044073539",{"VOID":1506},"https:\u002F\u002Forcid.org\u002F0000-0002-5558-423X",{"EN":1508},"Fengyun Wang",{"url":20,"publisher":1510,"properties":20},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1511,"slug":10,"properties":1512,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1516,"manageAffiliations":1517,"indexDatabases":1518,"url":20,"thumbnailPath":20,"statistic":1526,"gsStatistic":20,"type":99,"analyzePriority":20},[],{"issn":1513,"title":1514,"url":1515},{"VOID":13},{"EN":15},{"VOID":17},[],[],[1519],{"id":62,"indexDatabase":1520,"url":75,"indexYears":76,"academicFieldIds":1525,"indexDatabaseRanking":81},{"id":64,"createTime":65,"updateTime":66,"relativeEntities":1521,"label":1522,"description":1523,"key":72,"publicationTags":1524,"standard":20},[],{"EN":69,"VI":69},{"EN":69,"VI":71},[74],[78,79,80],{"impactFactor":21,"impactFactorByYear":1527,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":84,"totalPublicationByYear":1528,"totalCitation":94,"totalCitationByYear":1529,"totalCitationPerPublication":96,"totalCitationPerPublicationByYear":1530,"hindexLast5Year":94,"hindex":94},{},{"2015":86,"2016":87,"2017":88,"2018":89,"2019":90,"2020":91,"2021":92,"2022":92,"2023":88,"2024":93},{"2015":94},{"2015":98},{"total":172,"publishYear":20,"statisticByYear":1532},{"2022":94,"2023":94},"ERROR_IN_ANALYZE_CITATION","2024-04-11T23:20:21.995+00:00",[1536,1540,1544,1548,1552,1556,1560,1564,1568,1572,1576,1580,1583,1587,1591,1595,1599,1603,1607,1611,1615,1619,1622,1626,1630,1634,1638],{"id":20,"text":1537,"url":20,"identifiers":1538},"Choi 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National Institute for Health and Care Excellence; 2013.\nAAOS Guideline on The Treatment of Osteoporotic Spinal Compression Fractures. http:\u002F\u002Fwww.aaos.org\u002FResearch\u002Fguidelines\u002FSCFsummary.pdf. Accessed 2\u002F5\u002F2017.\nWood KB, Li W, Lebl DR, Ploumis A. Management of thoracolumbar spine fractures. Spine J. 2014;14(1):145–64. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.spinee.2012.10.041.\nPneumaticos SG, Triantafyllopoulos GK, Giannoudis PV. Advances made in the treatment of thoracolumbar fractures: current trends and future directions. Injury. 2013;44(6):703–12. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.injury.2012.12.005.\nAOSpine. AOSpine Thoracolumbar Classification System. https:\u002F\u002Faospine.aofoundation.org\u002FStructure\u002Feducation\u002Fonline-education\u002Fclassifications\u002FPages\u002Fclassifications.aspx. Accessed 14 Sept 2018.",{"EN":1652},"Most adult trauma protocols suggest that where there has been a dangerous mechanism of injury or the patient exhibits abnormal physiology, CT scan is the primary radiological investigation. Other patients who may have suffered thoraco-lumbar (T-L) trauma initially have antero-posterior (AP) and lateral plain X-rays performed. Our clinical experience suggests AP views are not particularly useful in the management of these relatively low-velocity injuries. This is the first study intended to determine the contribution made by AP X-rays in these cases. Adults with a history of T-L trauma referred to our tertiary spinal service over 20 weeks were reviewed. Those with a CT scan performed prior to X-rays were excluded. Four spine surgeons and four neuroradiologists were independently shown lateral X-rays along with the clinical details and asked to provide a management plan. Then they were shown the AP X-rays and asked if they would like to change their advice. Fifty-two patients were identified. Thirty-four sets of supine and 40 sets of erect X-rays were included (four people only had lateral X-rays performed), yielding 1152 film views. Average patient age was 58.3 years with 30 (58%) males. Forty-five (87%) were AO type A (compression-type) fractures. Seven (13%) had been erroneously referred with a diagnosis of acute fracture, which on review was not considered to be the case. Fifty-four percent of fractures were between T11 and L2. Forty-six percent appeared osteoporotic. In no instance did evaluation of the AP X-ray change the management plan which had been suggested following the evaluation of the lateral X-ray alone. However, there was significant variation in advice on further management between consultants. Our results suggest AP X-rays do not contribute to the management of low-velocity thoraco-lumbar traumas. Larger studies are required to support these findings, but there appears to be a potential to reduce both cost and radiation exposure. More importantly, it demonstrates there is large variability in the management of such patients due to the lack of evidence-based protocols.",{"EN":1654},"Usefulness of antero-posterior radiograph and variability of management in non-major thoracolumbar injuries: a single centre pilot study and review of literature",{"VOID":1656},"10.1186\u002Fs41016-018-0136-5","https:\u002F\u002Fcnjournal.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs41016-018-0136-5",[1659,1676,1688,1700],{"id":1660,"sortIndex":93,"researcher":20,"roles":1661,"affiliations":1662,"properties":1673},"a981d9cd-e619-491a-bd9b-7748aba6d1e0",[123],[1663],{"id":20,"sortIndex":21,"affiliation":1664,"properties":20},{"id":1665,"createTime":1666,"updateTime":1667,"relativeEntities":1668,"slug":1669,"properties":1670,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"093917c7-8f70-4a93-8912-54a4b9340b60","2023-12-09T02:33:57.299+00:00","2025-06-11T22:10:40.491+00:00",[],"South-West-Neurosurgery-Centre-Derriford-Hospital-Plymouth-UK",{"title":1671},{"VI":1672},"South West Neurosurgery Centre, Derriford Hospital, Plymouth, UK",{"title":1674},{"VI":1675},"Tim Germon",{"id":1677,"sortIndex":21,"researcher":20,"roles":1678,"affiliations":1679,"properties":1685},"ae842263-f486-4105-a24b-a04510e3556b",[123],[1680],{"id":20,"sortIndex":21,"affiliation":1681,"properties":20},{"id":1665,"createTime":1666,"updateTime":1667,"relativeEntities":1682,"slug":1669,"properties":1683,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1684},{"VI":1672},{"title":1686},{"VI":1687},"Jason 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Selbi",{"id":1701,"sortIndex":172,"researcher":20,"roles":1702,"affiliations":1703,"properties":1712},"36cd1097-8829-4f88-b53b-22b7a8f298d7",[123],[1704],{"id":20,"sortIndex":21,"affiliation":1705,"properties":20},{"id":1706,"createTime":1707,"updateTime":1707,"relativeEntities":1708,"slug":20,"properties":1709,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"e7d8a192-e049-42bd-b976-f780ea869c05","2024-01-16T20:39:16.630+00:00",[],{"title":1710},{"VI":1711},"Department of Radiology, Derriford Hospital, Plymouth, UK",{"title":1713},{"VI":1714},"Lucy Lee",{"url":1657,"publisher":1716,"properties":1737},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1717,"slug":10,"properties":1718,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1722,"manageAffiliations":1723,"indexDatabases":1724,"url":20,"thumbnailPath":20,"statistic":1732,"gsStatistic":20,"type":99,"analyzePriority":20},[],{"issn":1719,"title":1720,"url":1721},{"VOID":13},{"EN":15},{"VOID":17},[],[],[1725],{"id":62,"indexDatabase":1726,"url":75,"indexYears":76,"academicFieldIds":1731,"indexDatabaseRanking":81},{"id":64,"createTime":65,"updateTime":66,"relativeEntities":1727,"label":1728,"description":1729,"key":72,"publicationTags":1730,"standard":20},[],{"EN":69,"VI":69},{"EN":69,"VI":71},[74],[78,79,80],{"impactFactor":21,"impactFactorByYear":1733,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":84,"totalPublicationByYear":1734,"totalCitation":94,"totalCitationByYear":1735,"totalCitationPerPublication":96,"totalCitationPerPublicationByYear":1736,"hindexLast5Year":94,"hindex":94},{},{"2015":86,"2016":87,"2017":88,"2018":89,"2019":90,"2020":91,"2021":92,"2022":92,"2023":88,"2024":93},{"2015":94},{"2015":98},{"volume":1738,"pages":1740},{"VOID":1739},"4",{"VOID":1741},"1-8","2018-10-15",2018,{"id":1745,"createTime":1746,"updateTime":1747,"relativeEntities":1748,"slug":1749,"properties":1750,"entityType":117,"verifyStatus":318,"verifyTime":1747,"verifyNote":319,"syncStatus":19,"languages":1761,"translateLanguages":20,"viewCount":21,"primaryUrl":1762,"fullTextUrl":20,"authors":1763,"publicationType":270,"publisherRelationship":1821,"citationCount":21,"citationInfo":1846,"publishDate":1848,"publishYear":1849,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":1850,"isForceReanalyzing":300},"e04339aa-2c8d-474c-b11e-a3e3748b7554","2024-04-17T08:51:24.591+00:00","2025-02-19T22:57:32.989+00:00",[],"The-analysis-to-the-latest-changes-in-NCCN-Guidelines-of-Central-Nervous-System-Cancers-about-low-grade-gliomas-and-glioblastoma",{"mag":1751,"keywords":1753,"openalex":1754,"abstract":1756,"title":1757,"doi":1759},{"VOID":1752},"2190521349",{},{"VOID":1755},"W2190521349",{},{"EN":1758},"The analysis to the latest changes in NCCN Guidelines of Central Nervous System Cancers about low-grade gliomas and glioblastoma",{"VOID":1760},"10.1186\u002Fs41016-015-0014-3",[321],"http:\u002F\u002Fcnjournal.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs41016-015-0014-3",[1764,1785,1804],{"id":1765,"sortIndex":172,"researcher":20,"roles":1766,"affiliations":1767,"properties":1778},"b9f29e5f-85d3-4e91-b5a2-cf173bcf350a",[],[1768],{"id":1769,"sortIndex":21,"affiliation":1770,"properties":20},"41db16a5-c490-467b-b9ca-204e2f320bac",{"id":1771,"createTime":1772,"updateTime":1772,"relativeEntities":1773,"slug":1774,"properties":1775,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"e9c61cb6-00bb-4030-a653-bd23e391bce5","2024-04-17T08:51:24.656+00:00",[],"Beijing-Key-Laboratory-of-Brian-Tumor-Beijing-100050-China",{"title":1776},{"EN":1777},"Beijing Key Laboratory of Brian Tumor, Beijing, 100050, China",{"openalex":1779,"orcid":1781,"title":1783},{"VOID":1780},"A5079494298",{"VOID":1782},"https:\u002F\u002Forcid.org\u002F0000-0002-9001-8858",{"EN":1784},"Nan Ji",{"id":1786,"sortIndex":94,"researcher":20,"roles":1787,"affiliations":1788,"properties":1799},"659c5bcc-f041-46ec-aba0-4ebedf39e337",[],[1789],{"id":1790,"sortIndex":21,"affiliation":1791,"properties":20},"a25b54a0-b676-41ef-aff3-6087e238c768",{"id":1792,"createTime":1793,"updateTime":1793,"relativeEntities":1794,"slug":1795,"properties":1796,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"88e3ab3c-5076-4b64-b841-eee9ee39fb85","2024-04-17T08:51:24.643+00:00",[],"Department-of-Neurosurgery-Beijing-Tiantan-Hospital-Capital-Medical-University-6-Tian-Tan-Xi-Li-Beijing-100050-China",{"title":1797},{"EN":1798},"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 6 Tian Tan Xi Li, Beijing, 100050, China",{"openalex":1800,"title":1802},{"VOID":1801},"A5089770212",{"EN":1803},"Xiong Xiao",{"id":1805,"sortIndex":21,"researcher":20,"roles":1806,"affiliations":1807,"properties":1814},"c775832b-c3cd-4be9-bcf8-f0655e049ca1",[],[1808],{"id":1809,"sortIndex":21,"affiliation":1810,"properties":20},"9fc7285a-981f-464f-8095-7b7e83433c58",{"id":1792,"createTime":1793,"updateTime":1793,"relativeEntities":1811,"slug":1795,"properties":1812,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1813},{"EN":1798},{"openalex":1815,"orcid":1817,"title":1819},{"VOID":1816},"A5062542913",{"VOID":1818},"https:\u002F\u002Forcid.org\u002F0009-0000-2095-431X",{"EN":1820},"Tianyu Wang",{"url":20,"publisher":1822,"properties":1843},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1823,"slug":10,"properties":1824,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1828,"manageAffiliations":1829,"indexDatabases":1830,"url":20,"thumbnailPath":20,"statistic":1838,"gsStatistic":20,"type":99,"analyzePriority":20},[],{"issn":1825,"title":1826,"url":1827},{"VOID":13},{"EN":15},{"VOID":17},[],[],[1831],{"id":62,"indexDatabase":1832,"url":75,"indexYears":76,"academicFieldIds":1837,"indexDatabaseRanking":81},{"id":64,"createTime":65,"updateTime":66,"relativeEntities":1833,"label":1834,"description":1835,"key":72,"publicationTags":1836,"standard":20},[],{"EN":69,"VI":69},{"EN":69,"VI":71},[74],[78,79,80],{"impactFactor":21,"impactFactorByYear":1839,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":84,"totalPublicationByYear":1840,"totalCitation":94,"totalCitationByYear":1841,"totalCitationPerPublication":96,"totalCitationPerPublicationByYear":1842,"hindexLast5Year":94,"hindex":94},{},{"2015":86,"2016":87,"2017":88,"2018":89,"2019":90,"2020":91,"2021":92,"2022":92,"2023":88,"2024":93},{"2015":94},{"2015":98},{"volume":1844,"issue":1845},{"VOID":459},{"VOID":459},{"total":21,"publishYear":20,"statisticByYear":1847},{},"2015-12-01",2015,[1851,1855,1859,1863,1867,1871,1874,1877,1880,1884,1888,1892,1896,1900,1904,1908,1912,1916,1920,1923,1927,1931,1935,1939,1943],{"id":20,"text":1852,"url":20,"identifiers":1853},"Ricard D, Idbaih A, Ducray F, Lahutte M, Hoang-Xuan K, Delattre JY. Primary brain tumours in adults. Lancet. 2012;379(9830):1984–96.",{"doi":1854},"10.1016\u002FS0140-6736(11)61346-9",{"id":20,"text":1856,"url":20,"identifiers":1857},"Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. The 2007 WHO classification of tumours of the central nervous system. Acta neuropathologica. 2007;114(2):97–109.",{"doi":1858},"10.1007\u002Fs00401-007-0243-4",{"id":20,"text":1860,"url":20,"identifiers":1861},"Levin VA, Silver P, Hannigan J, Wara WM, Gutin PH, Davis RL, et al. Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarbazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report. Int J Radiat Oncol Biol Phys. 1990;18:321–4.",{"doi":1862},"10.1016\u002F0360-3016(90)90096-3",{"id":20,"text":1864,"url":20,"identifiers":1865},"Keasari S, Scgiff D, Drappatz J, LaFrankie D, Doherty L, Macklin EA, et al. Phase II study of protracted daily temozolomide for low-grade gliomas in adults. Clin Cancer Res. 2009;15:330–7.",{"doi":1866},"10.1158\u002F1078-0432.CCR-08-0888",{"id":20,"text":1868,"url":20,"identifiers":1869},"Pouratian N, Gasco J, Sherman JH, Shaffrey ME, Schiff D. Toxicity and efficacy of protracted low dose temozolomide for the treatment of low-grade gliomas. J Neurooncol. 2007;82:281–8.",{"doi":1870},"10.1007\u002Fs11060-006-9280-4",{"id":20,"text":1872,"url":20,"identifiers":1873},"Shaw EG, Wang M, Coons SW, Brachman DG, Buckner JC, Stelzer KJ, et al. Randomized trial of radiation therapy plus procarbazine, lomustine, and vincristine chemotherapy for supratentorial adult low-grade gliom:initial results of RTOG 9802. J Neurooncol. 2012;30:3065–70.",{},{"id":20,"text":1875,"url":20,"identifiers":1876},"Chamberlain MCDOESRTOG. 9802 change practice with respect to newly diagnosed low-grade glioma? J Neurooncol. 2013;31:652–3.",{},{"id":20,"text":1878,"url":20,"identifiers":1879},"van den Bent MJ, Jaeckle K, Baumert B, Wick W. BRTOG 9802:good wines need aging. J Neurooncol. 2013;31:653–4.",{},{"id":20,"text":1881,"url":20,"identifiers":1882},"Perry JR, Rizek P, Cashman R, Morrison M, Morrison T. Temozolomide rechallenge in recurrent malignant glioma by using a continuous temozolomide schedule:the “rescue” approach. Cancer. 2008;113:2152–7.",{"doi":1883},"10.1002\u002Fcncr.23813",{"id":20,"text":1885,"url":20,"identifiers":1886},"Cairncross G, Wang M, Shaw E, Jenkins R, Brachman D, Buckner J, et al. Phase III Trial of Chemoradiotherapy for Anaplastic Oligodendroglioma: Long-Term Results of RTOG 9402. J Clin Oncol. 2013;31(3):337–43.",{"doi":1887},"10.1200\u002FJCO.2012.43.2674",{"id":20,"text":1889,"url":20,"identifiers":1890},"van den Bent MJ. Practice changing mature results of RTOG study 9802: another positive PCV trial makes adjuvant chemotherapy part of standard of care in low-grade glioma. Neuro-Oncology. 2014;16(12):1570–4.",{"doi":1891},"10.1093\u002Fneuonc\u002Fnou297",{"id":20,"text":1893,"url":20,"identifiers":1894},"Massimino M, Spreafico F, Riva D, Biassoni V, Poggi G, Solero C, et al. A lower-dose,lower-toxicity cisplatin-etoposide regimen for childhood progressive low-grade glioma. J Neurooncol. 2010;100(1):65–71.",{"doi":1895},"10.1007\u002Fs11060-010-0136-6",{"id":20,"text":1897,"url":20,"identifiers":1898},"Moghrabi A, Friedman HS, Ashley DM, Bottom KS, Kerby T, Stewart E, et al. Phase II study of carboplatin(CBDCA) in progressive low-grade gliomas. Neurosurg Focus. 1998;4:e3.",{"doi":1899},"10.3171\u002Ffoc.1998.4.4.6",{"id":20,"text":1901,"url":20,"identifiers":1902},"Brandes AA, Basso U, Vastola F, Tosoni A, Pasetto LM, Jirillo A, et al. Carboplain and teniposide as third-line chemotherapy in patients with recurrent oligodendroglioma or oligoastasrocytoma:a phase II study. Ann Oncol. 2003;14:1727–31.",{"doi":1903},"10.1093\u002Fannonc\u002Fmdg494",{"id":20,"text":1905,"url":20,"identifiers":1906},"Hoang-Xuan K, Capelle L, Kujas M, Taillibert S, Duffau H, Lejeune J, et al. Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastasrocytomas and correlation with chromosome 1p deletions. J Clin Oncol. 2004;22:3133–8.",{"doi":1907},"10.1200\u002FJCO.2004.10.169",{"id":20,"text":1909,"url":20,"identifiers":1910},"Kaloshi G, Benouaich-Amiel A, Diakite F, Taillibert S, Lejeune J, Laigle-Donadey F, et al. Temozolomide for low-grade gliomas:predictive impact of 1p\u002F19q loss on response and outcome. Neurology. 2007;68:1831–6.",{"doi":1911},"10.1212\u002F01.wnl.0000262034.26310.a2",{"id":20,"text":1913,"url":20,"identifiers":1914},"Buckner JC, Gesme Jr D, O’Fallon JR. Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastasrocytoma:efficacy and associations with chromosomal abnormalities. J Clin Oncol. 2003;21:251–5.",{"doi":1915},"10.1200\u002FJCO.2003.06.023",{"id":20,"text":1917,"url":20,"identifiers":1918},"Cairncross G, Macdonald D, Ludwin S, Lee D, Cascino T, Buckner J, et al. Chemotherapy for anaplastic oligodendroglioma. National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 1994;12:2013–21.",{"doi":1919},"10.1200\u002FJCO.1994.12.10.2013",{"id":20,"text":1921,"url":20,"identifiers":1922},"Ino Y, Betensky RA, Zlatescu MC, Sasaki H, Macdonald DR, Stemmer-Rachamimov AO, et al. Molecular subtypes of anaplastic oligodendroglioma. Clin Cancer Res. 2001;7:839–45.",{},{"id":20,"text":1924,"url":20,"identifiers":1925},"van den Bent M, Chinot OL, Cairncross JG. Recent developments in the molecular characterization and treatment of oligodendroglial tumors. Neuro oncol. 2003;5:128–38.",{"doi":1926},"10.1093\u002Fneuonc\u002F5.2.128",{"id":20,"text":1928,"url":20,"identifiers":1929},"Buckner JC, Pugh SL, Shaw EG, Gilbert MR, Barger G, Coons S, et al. Phase III study of radiation therapy (RT) with or without procarbazine, CCNU, and vincristine (PCV) in low-grade glioma: RTOG 9802 with Alliance, ECOG, and SWOG. J Clin Oncol. 2014;32:5s. abstract #2000.",{"doi":1930},"10.1200\u002FJCO.2013.49.4757",{"id":20,"text":1932,"url":20,"identifiers":1933},"Medical Research Council Brain Tumor Working Party. Randomized trial of procaibazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: a Medical Research Council trial. J Clin Oncol. 2001;19:509–18.",{"doi":1934},"10.1200\u002FJCO.2001.19.2.509",{"id":20,"text":1936,"url":20,"identifiers":1937},"Stewart LA. Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of inndividual patient data from 12 randomised trials. Lancet. 2002;359:1011–8.",{"doi":1938},"10.1016\u002FS0140-6736(02)08091-1",{"id":20,"text":1940,"url":20,"identifiers":1941},"Fine HA, Dear KB, Loeffler JS, Black PM, Canellos GP. Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer. 1993;71:2585–97.",{"doi":1942},"10.1002\u002F1097-0142(19930415)71:8\u003C2585::AID-CNCR2820710825>3.0.CO;2-S",{"id":20,"text":1944,"url":20,"identifiers":1945},"Stupp R, Wong ET, Kanner AA, Steinberg D, Engelhard H, Heidecke V, et al. Novo TTF-100A versus physician’s choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality. Eur J Cancer. 2012;48(14):2192–202.",{"doi":1946},"10.1016\u002Fj.ejca.2012.04.011",{"id":1948,"createTime":1949,"updateTime":1949,"relativeEntities":1950,"slug":1951,"properties":1952,"entityType":117,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":1968,"translateLanguages":20,"viewCount":21,"primaryUrl":1969,"fullTextUrl":20,"authors":1970,"publicationType":270,"publisherRelationship":2045,"citationCount":93,"citationInfo":2070,"publishDate":2072,"publishYear":636,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":2073,"isForceReanalyzing":300},"a069c62d-edb7-4441-bc16-735d9644a3fb","2024-04-21T22:51:59.056+00:00",[],"Idiopathic-and-radiation-induced-myxofibrosarcoma-in-the-head-and-neck-case-report-and-literature-review",{"mag":1953,"keywords":1955,"pmc":1956,"openalex":1958,"abstract":1960,"title":1962,"pm":1964,"doi":1966},{"VOID":1954},"3160095879",{},{"VOID":1957},"8620227",{"VOID":1959},"W3160095879",{"EN":1961},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\n                \u003Cjats:title>Background\u003C\u002Fjats:title>\n                \u003Cjats:p>Myxofibrosarcoma (MFS), especially radiation-Induced MFS (RIMFS) in the head and neck, is an extremely rare malignant fibroblastic tumor. The diagnosis and treatment of MFS remain great challenges. In the present study, we presented one case of RIMFS. Combined with previous literature, the clinical features, essentials of diagnosis, and treatment modalities of MFS in the head and neck were reviewed to better understand this rare entity.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>\u003Cjats:sec>\n                \u003Cjats:title>Case presentation\u003C\u002Fjats:title>\n                \u003Cjats:p>We reported a case of RIMFS under the left occipital scalp in a 20-year-old girl with a history of medulloblastoma surgery and radiotherapy in 2006. A total tumor resection was performed with preservation of the overlying scalp the underlying bone, and no adjuvant therapy was administered after the first operation. The postoperative pathological diagnosis was high-grade MFS. The tumor relapsed 6 months later, and then, a planned extensive resection with negative surgical margins was carried out, followed by radiotherapy. No relapse occurred in a 12-month postoperative follow-up.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>\u003Cjats:sec>\n                \u003Cjats:title>Conclusions\u003C\u002Fjats:title>\n                \u003Cjats:p>Planned gross total resection (GTR) with negative margins is the reasonable choice and footstone of other treatments for MFS. Ill-defined infiltrated borders and the complicated structures make it a great trouble to achieve total resection of MFS in the head and neck, so adjuvant radiotherapy and chemotherapy seem more necessary for these lesions.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>",{"EN":1963},"Idiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature 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Beijing Tian Tan Hospital, Capital Medical University, No.119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, People's Republic of China",{"openalex":1986,"orcid":1988,"title":1990},{"VOID":1987},"A5046881277",{"VOID":1989},"https:\u002F\u002Forcid.org\u002F0000-0002-1529-6356",{"EN":1991},"Bin Zhang",{"id":1993,"sortIndex":93,"researcher":20,"roles":1994,"affiliations":1995,"properties":2002},"8dc7571c-bc66-4f8d-804f-9fd9c10193a7",[],[1996],{"id":1997,"sortIndex":21,"affiliation":1998,"properties":20},"56928e84-740d-420a-ac12-bc342aff63a8",{"id":1978,"createTime":1979,"updateTime":1979,"relativeEntities":1999,"slug":1981,"properties":2000,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":2001},{"EN":1984},{"openalex":2003,"title":2005},{"VOID":2004},"A5086301136",{"EN":2006},"Shuyu 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